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https://www.readbyqxmd.com/read/28092367/molecular-architecture-and-dynamics-of-ash1-mrna-recognition-by-its-mrna-transport-complex
#1
Franziska Theresia Edelmann, Andreas Schlundt, Roland Gerhard Heym, Andreas Jenner, Annika Niedner-Boblenz, Muhammad Ibrahim Syed, Jean-Christophe Paillart, Ralf Stehle, Robert Janowski, Michael Sattler, Ralf-Peter Jansen, Dierk Niessing
mRNA localization is an essential mechanism of gene regulation and is required for processes such as stem-cell division, embryogenesis and neuronal plasticity. It is not known which features in the cis-acting mRNA localization elements (LEs) are specifically recognized by motor-containing transport complexes. To the best of our knowledge, no high-resolution structure is available for any LE in complex with its cognate protein complex. Using X-ray crystallography and complementary techniques, we carried out a detailed assessment of an LE of the ASH1 mRNA from yeast, its complex with its shuttling RNA-binding protein She2p, and its highly specific, cytoplasmic complex with She3p...
January 16, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28069027/reliability-of-health-related-quality-of-life-assessments-made-by-older-adults-and-significant-others-for-health-states-of-increasing-cognitive-impairment
#2
Gina Bravo, Modou Sene, Marcel Arcand
BACKGROUND: Older adults are encouraged by many organizations to engage in advance care planning in the event of decisional incapacity. Planning for future health care often involves anticipating health-related quality of life (HRQoL) in states of reduced cognitive functioning. No study has yet examined whether anticipated HRQoL is stable over time. The accuracy with which significant others can predict how an older adult envisions HRQoL in a future state of cognitive impairment is also unknown...
January 7, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28069003/the-chinese-version-of-achilles-tendon-total-rupture-score-cross-cultural-adaptation-reliability-and-validity
#3
Jin Cui, Zhenyu Jia, Xin Zhi, Xiaoqun Li, Xiao Zhai, Liehu Cao, Weizong Weng, Jun Zhang, Lin Wang, Xiao Chen, Jiacan Su
BACKGROUND: The Achilles tendon Total Rupture Score (ATRS), which is originally developed in 2007 in Swedish, is the only patient-reported outcome measure (PROM) for specific outcome assessment of an Achilles tendon rupture.Purpose of this study is to translate and cross-culturally adapt Achilles tendon Total Rupture Score (ATRS) into simplified Chinese, and primarily evaluate the responsiveness, reliability and validity. METHODS: International recognized guideline which was designed by Beaton was followed to make the translation of ATRS from English into simplified Chinese version (CH-ATRS)...
January 5, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28062980/assessment-of-an-apobec3b-truncating-mutation-c-783delg-in-patients-with-breast-cancer
#4
Hoda Radmanesh, Tessa Spethmann, Julia Enßen, Peter Schürmann, Sabin Bhuju, Robert Geffers, Natalia Antonenkova, Elza Khusnutdinova, Ariane Sadr-Nabavi, Fatemeh Homaei Shandiz, Tjoung-Won Park-Simon, Peter Hillemanns, Hans Christiansen, Natalia Bogdanova, Thilo Dörk
PURPOSE: APOBEC3B belongs to the family of DNA-editing enzymes. A copy number variant targeting the genomic APOBEC3A-APOBEC3B locus has a significant impact on breast cancer risk, but the relative contribution of APOBEC3B is uncertain. In this study, we investigate a loss-of-function mutation that selectively targets APOBEC3B, for its association with breast cancer risk. METHODS: We performed exome sequencing on genomic DNA samples of 6 Byelorussian patients with familial breast cancer...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28059948/sports-related-concussion-in-children-and-adolescents
#5
Christian A Refakis, Christian D Turner, Patrick J Cahill
Concussions are becoming increasingly important to manage properly as sports participation continues to rise. Repeated injuries occurring before the brain has had a chance to recover from an initial insult are particularly dangerous and must be prevented. Although much national media attention has been devoted to concussions in professional sports, it is important to appreciate that athletes in any age group, children and adolescents in particular, are at risk of sports-related concussion. It is crucial to remove an athlete from play any time concussion is suspected...
January 4, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28041872/use-of-dual-energy-x-ray-absorptiometry-dxa-for-diagnosis-and-fracture-risk-assessment-who-criteria-t-and-z-score-and-reference-databases
#6
Hans P Dimai
Dual-energy X-ray absorptiometry (DXA) is a two-dimensional imaging technology developed to assess bone mineral density (BMD) of the entire human skeleton and also specifically of skeletal sites known to be most vulnerable to fracture. In order to simplify interpretation of BMD measurement results and allow comparability among different DXA-devices, the T-score concept was introduced. This concept involves an individual's BMD which is then compared with the mean value of a young healthy reference population, with the difference expressed as a standard deviation (SD)...
December 29, 2016: Bone
https://www.readbyqxmd.com/read/28034999/perceptions-of-snus-among-us-adult-smokers-given-free-product
#7
Ellen Meier, Jessica L Burris, Amy Wahlquist, Elizabeth Garrett-Mayer, Kevin M Gray, Anthony J Alberg, K Michael Cummings, Matthew J Carpenter
INTRODUCTION: Snus uptake is nominal among US smokers. This longitudinal study examines a) perceptions of snus among US smokers given free snus for six weeks and b) a method for assessment of an alternative tobacco product at the population level. METHODS: Adult smokers (n=543; 69.2% female; Mage=49.3 years), uninterested in quitting, received free snus for ad libitum use. Based on their snus use during a 6-week sampling period, participants included: 1) never users (18...
December 29, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28012776/a-novel-in-feed-delivery-platform-applied-for-oral-dna-vaccination-against-ipnv-enables-high-protection-in-atlantic-salmon-salmon-salar
#8
Miguel Reyes, Cesar Ramírez, Ivan Ñancucheo, Ricardo Villegas, Guillermo Schaffeld, Luis Kiman, Javier Gonzalez, Patricio Oyarzun
BACKGROUND: DNA vaccination has emerged as a promising tool against infectious diseases of farmed fish. Oral delivery allows stress-free administration that is ideal for mass immunization and of paramount importance for infectious pancreatic necrosis (IPN) and other viral disease that affect young salmonids and cause economic losses in aquaculture worldwide. METHODS: We describe the development and in vivo assessment of an "in-feed" formulation strategy for oral immunization with liposomal DNA vaccines, by delivering a vaccine construct coding for an immunogenic region of the VP2 capsid protein...
December 21, 2016: Vaccine
https://www.readbyqxmd.com/read/28012705/methodology-for-analyzing-environmental-quality-indicators-in-a-dynamic-operating-room-environment
#9
Thomas Gormley, Troy A Markel, Howard W Jones, Jennifer Wagner, Damon Greely, James H Clarke, Mark Abkowitz, John Ostojic
BACKGROUND: Sufficient quantities of quality air and controlled, unidirectional flow are important elements in providing a safe building environment for operating rooms. METHODS: To make dynamic assessments of an operating room environment, a validated method of testing the multiple factors influencing the air quality in health care settings needed to be constructed. These include the following: temperature, humidity, particle load, number of microbial contaminants, pressurization, air velocity, and air distribution...
December 21, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27989240/assessment-of-an-aggregate-level-hand-hygiene-monitoring-technology-for-measuring-hand-hygiene-performance-among-healthcare-personnel
#10
Heather M Limper, Lynn Slawsky, Sylvia Garcia-Houchins, Supriya Mehta, Ronald C Hershow, Emily Landon
BACKGROUND Despite significant advances in technological methods for hand hygiene surveillance, a lack of evidence prohibits comparison of systems to one another or against the current gold standard of direct observation. OBJECTIVE To validate a hand hygiene monitoring technology (HHMT) designed to capture hand hygiene behaviors aggregated at the hospital-unit level (GOJO Industries, Akron, OH). METHODS Our team followed a rigorous validation approach to assess the sensitivity and positive predictive value (PPV) of an HHMT...
December 19, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27959351/fatal-haemorrhage-following-fine-needle-aspiration-of-the-thyroid
#11
M W Strachan, M Dalvi, R Ainsworth, F W Gibb, H Horsfall, D Patel
Fine needle aspiration is routinely performed as part of the assessment of thyroid nodules. It is generally regarded as a very safe procedure, though rarely significant bleeding can occur in its aftermath. A 79-year-old female was referred for assessment of an incidental thyroid nodule which had been identified on computed tomography of the chest and extended into the retrosternal space. The patient was referred for fine needle aspiration under ultrasound guidance. Three passes were made with a 25 gauge needle into the nodule; a haemorrhagic aspirate was obtained and sent for cytological examination...
September 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/27939830/in%C3%A2-vitro-toxicological-assessment-of-an-organosulfur-compound-from-allium-extract-cytotoxicity-mutagenicity-and-genotoxicity-studies
#12
Pilar Mellado-García, Sara Maisanaba, María Puerto, Ana Isabel Prieto, Ricard Marcos, Silvia Pichardo, Ana María Cameán
Garlic (Allium sativum) and onion (Allium cepa) are being used in the food industry as flavoring but also for their antimicrobial activities. These activities are mainly derived from the organosulfur compounds (OSCs). Propyl propane thiosulfinate (PTS) is an OSC with potential use in the active packaging, but its safety should be guaranteed before being commercialized. The aim of this work was to investigate for the first time the cytotoxicity of PTS as well as its in vitro mutagenic/genotoxic potential using the following battery of genotoxicity tests:(1)the bacterial reverse-mutation assay in S...
January 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27935435/improving-nursing-students-assessment-of-fall-risk-in-community-dwelling-older-adults
#13
Susan K Patton
BACKGROUND: Nationally, approximately one-third of older adults fall each year. Falls and resulting injury result in decreased mobility, functional impairment, loss of independence, and increased mortality. Utilization of evidence based protocols by health care providers to identify older adults at risk of falling is limited and rates of participation by older adults in prevention activities is low. Because of nursing's increasing role in caring for older adults, development of fall prevention education for nursing students would result in increased awareness of the need for fall prevention in community dwelling older adults and increased access of older adults to falls risk assessment...
December 9, 2016: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/27908385/the-mutagenic-assessment-of-an-electronic-cigarette-and-reference-cigarette-smoke-using-the-ames-assay-in-strains-ta98-and-ta100
#14
D Thorne, I Crooks, M Hollings, A Seymour, C Meredith, M Gaca
Salmonella typhimurium strains TA98 and TA100 were used to assess the mutagenic potential of the aerosol from a commercially available, rechargeable, closed system electronic-cigarette. Results obtained were compared to those for the mainstream smoke from a Kentucky reference (3R4F) cigarette. Two different test matrices were assessed. Aerosol generated from the e-cigarette was trapped on a Cambridge filter pad, eluted in DMSO and compared to cigarette smoke total particulate matter (TPM), which was generated in the same manner for mutagenicity assessment in the Salmonella assay...
December 2016: Mutation Research
https://www.readbyqxmd.com/read/27890388/uganda-experience-using-cost-assessment-of-an-established-registry-to-project-resources-required-to-expand-cancer-registration
#15
Henry Wabinga, Sujha Subramanian, Sarah Nambooze, Phoebe Mary Amulen, Patrick Edwards, Rachael Joseph, Martin Ogwang, Francis Okongo, D Maxwell Parkin, Florence Tangka
BACKGROUND: The objectives of this study are (1) to estimate the cost of operating the Kampala Cancer Registry (KCR) and (2) to use cost data from the KCR to project the resource needs and cost of expanding and sustaining cancer registration in Uganda, focusing on the recently established Gulu Cancer Registry (GCR) in rural Northern Uganda. METHODS: We used Centers for Disease Control and Prevention's (CDC's) International Registry Costing Tool (IntRegCosting Tool) to estimate the KCR's activity-based cost for 2014...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27871594/obstetric-team-simulation-program-challenges
#16
A S Bullough, S Wagner, T Boland, T P Waters, K Kim, W Adams
OBJECTIVE: To describe the challenges associated with the development and assessment of an obstetric emergency team simulation program. DESIGN: The goal was to develop a hybrid, in-situ and high fidelity obstetric emergency team simulation program that incorporated weekly simulation sessions on the labor and delivery unit, and quarterly, education protected sessions in the simulation center. All simulation sessions were video-recorded and reviewed. SETTING: Labor and delivery unit and simulation center...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27870892/body-weight-can-change-how-your-emotions-are-perceived
#17
Yujung Oh, Norah C Hass, Seung-Lark Lim
Accurately interpreting other's emotions through facial expressions has important adaptive values for social interactions. However, due to the stereotypical social perception of overweight individuals as carefree, humorous, and light-hearted, the body weight of those with whom we interact may have a systematic influence on our emotion judgment even though it has no relevance to the expressed emotion itself. In this experimental study, we examined the role of body weight in faces on the affective perception of facial expressions...
2016: PloS One
https://www.readbyqxmd.com/read/27850071/431-assessment-of-an-innovative-critical-care-pharmacy-elective
#18
Craig Whitman, Neela Bhajandas, Christina Rose
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27811534/performance-in-trauma-resuscitation-at-an-urban-tertiary-level-i-pediatric-trauma-center
#19
Payal Kadia Gala, Kevin Osterhoudt, Sage R Myers, Mariel Colella, Aaron Donoghue
BACKGROUND: The role of the surveyor in trauma resuscitations is to identify life-threatening injuries and is meant to be conducted by a set protocol for every patient. Optimal performance of the trauma survey is known to be a challenge in pediatric trauma resuscitation. A postulated reason for this observation is that many trainees, such as pediatric residents, who perform the trauma survey have minimal experience and do not have formal advanced trauma life support training. The assessment of factors that may be obstacles in performing the trauma survey has not been studied robustly...
November 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27806095/microbial-community-evolution-is-significantly-impacted-by-the-use-of-calcium-isosaccharinic-acid-as-an-analogue-for-the-products-of-alkaline-cellulose-degradation
#20
Isaac A Kyeremeh, Christopher J Charles, Simon P Rout, Andrew P Laws, Paul N Humphreys
Diasteriomeric isosaccharinic acid (ISA) is an important consideration within safety assessments for the disposal of the United Kingdoms' nuclear waste legacy, where it may potentially influence radionuclide migration. Since the intrusion of micro-organisms may occur within a disposal concept, the impact of ISA may be impacted by microbial metabolism. Within the present study we have established two polymicrobial consortia derived from a hyperalkaline soil. Here, α-ISA and a diatereomeric mix of ISAs' were used as a sole carbon source, reflecting two common substrates appearing within the literature...
2016: PloS One
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