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https://www.readbyqxmd.com/read/28685333/chrysotile-and-rock-wool-fibers-induce-chromosome-aberrations-and-dna-damage-in-v79-lung-fibroblast-cells
#1
Yan Cui, Ji Ma, Wei Ye, Zhixia Han, Faqin Dong, Jianjun Deng, Qingbi Zhang
According to global estimates, at least 107,000 people die each year from asbestos-related lung cancer, mesothelioma, and asbestosis resulting from occupational exposure. Chrysotile accounts for approximately 90% of asbestos used worldwide. Artificial substitutes can also be cytotoxic to the same degree as chrysotile. But only a few researchers focused on their genetic effects and mutagenicity information which is useful in evaluating the carcinogenicity of chemicals. In this study, chrysotile from Mangnai, Qinghai, China, and an artificial substitute, rock wool fiber were prepared as suspensions and were tested at concentrations of 50, 100, and 200 μg/ml in V79 lung fibroblasts...
July 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28593073/cancer-incidence-in-asbestos-exposed-workers-an-update-on-four-finnish-cohorts
#2
Pia Nynäs, Eero Pukkala, Harri Vainio, Panu Oksa
BACKGROUND: We assessed the cancer risks of four different Finnish asbestos-exposed cohorts. We also explored if the cohorts with varying profiles of asbestos exposure exhibited varying relative risks of cancer. METHODS: The incident cancer cases for the asbestos-exposed worker cohorts were updated to the end of 2012 using the files of the Finnish Cancer Registry. The previously formed cohorts consisted of asbestos mine workers, asbestosis patients, asbestos sprayers, and workers who had taken part in a screening study based on asbestos exposure at work...
June 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28162043/chest-ultrasonography-in-health-surveillance-of-asbestos-related-lung-diseases
#3
Andrea Smargiassi, Giuliana Pasciuto, Ilaria Pedicelli, Erminia Lo Greco, Mariarosaria Calvello, Riccardo Inchingolo, Gioacchino Schifino, Patrizio Capoluongo, Pasquale Patriciello, Maurizio Manno, Alfonso Cirillo, Giuseppe Maria Corbo, Gino Soldati, Ivo Iavicoli
OBJECTIVES: Exposure to asbestos fibers can lead to different lung diseases, such as pleural thickening and effusion, asbestosis, mesothelioma, and lung cancer. These diseases are expected to peak in the next few years. The aim of the study was to validate ultrasonography (US) as a diagnostic tool in the management of lung diseases in subjects with a history of occupational exposure to asbestos. METHODS: Fifty-nine retired male workers previously exposed to asbestos were enrolled in the study...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28002541/distinction-between-mesothelioma-and-lung-adenocarcinoma-based-on-immunohistochemistry-in-a-patient-with-asbestos-bodies-in-bronchoalveolar-fluid-case-report
#4
Agripina Raşcu, Eugenia Naghi, Marina Ruxandra OŢelea, Floarea Mimi NiŢu, Oana Cristina Arghir
Asbestos is a mineral-mined form the rocks, consisting in amosite (brown asbestos), crocidolite (blue asbestos) and÷or chrysotile (white asbestos) used in many industries. Researches about the exposure to asbestos dust and asbestosis related diseases started almost a century ago. The first case report of fatal asbestosis disease was published in 1906, in England, by Dr. Hubert Montague Murray. A decade after, asbestos "curious bodies" were firstly described in the lung tissue by Cooke (1926) and McDonald (1927)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27705550/tyler-asbestos-workers-a-mortality-update-in-a-cohort-exposed-to-amosite
#5
Jeffrey L Levin, Alina Rouk, Sara Shepherd, George A Hurst, Jerry W McLarty
The Tyler asbestos plant produced pipe insulation from 1954 to 1972 and exclusively used amosite asbestos. There were 1130 former workers of this plant during the period of operation. A death certificate mortality analysis was published regarding this plant in 1998 for the period through 1993. This study represents an update of the mortality analysis with additional certificates collected for deaths occurring through 2011.Searches of the National Death Index database were conducted in 2004 and again in 2013...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/27650313/the-nlrp3-inflammasome-in-pathogenic-particle-and-fibre-associated-lung-inflammation-and-diseases
#6
REVIEW
Mutlay Sayan, Brooke T Mossman
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago. Priming and activation of these intracellular protein platforms trigger the maturation of pro-inflammatory chemokines and cytokines, most notably, interleukin-1β (IL-1β) and IL-18, to promulgate innate immune defenses. Although classically studied in models of gout, Type II diabetes, Alzheimer's disease, and multiple sclerosis, the importance and mechanisms of action of inflammasome priming and activation have recently been elucidated in cells of the respiratory tract where they modulate the responses to a number of inhaled pathogenic particles and fibres...
September 20, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27540559/asbestos-fiber-preparation-methods-affect-fiber-toxicity
#7
Ashkan Salamatipour, Sanjay K Mohanty, Ralph A Pietrofesa, David R Vann, Melpo Christofidou-Solomidou, Jane K Willenbring
To measure the toxic potential of asbestos fibers-a known cause of asbestosis, lung cancer, and malignant mesothelioma-asbestos minerals are generally first ground down to small fibers, but it is unknown whether the grinding condition itself changes the fiber toxicity. To evaluate this, we ground chrysotile ore with or without water for 5-30 min and quantified asbestos-induced reactive oxygen species generation in elicited murine peritoneal macrophages as an indicator of fiber toxicity. The toxicity of dry-ground fibers was higher than the toxicity of wet-ground fibers...
July 12, 2016: Environmental Science & Technology Letters
https://www.readbyqxmd.com/read/27516637/medical-monitoring-of-asbestos-exposed-workers-experience-from-poland
#8
Beata Świątkowska, Neonila Szeszenia-Dąbrowska, Urszula Wilczyńska
In Poland, the use of asbestos was banned in 1997 and asbestos plants have been closed since then. Despite their closure, cases of asbestos-related occupational diseases among former asbestos workers are still being recorded in the Central Register of Occupational Diseases. Between 2001 and 2014, there were 2726 asbestos-related illnesses, classified and reported as diseases associated with occupational exposure to asbestos. In 2000, Poland introduced a programme called Amiantus, targeted at former asbestos-processing plant workers...
August 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27476317/-asbestos-an-up-to-date-general-review
#9
Michel Aubier
Major risks associated with asbestos exposure (mesothelioma, lung cancer and asbestosis) have been knownfor a long time. Various clinical and epidemiological studies, which include assessment of risk of developing cancer after discovering atypical computer-tomography (CT) images or pleural plaques in persons who had been exposed to asbestos, are still ongoing, however. This short report updates the risk of occupational exposure in 2014, the consequences of the former occupational exposures, the scale of compensation and recent legal dispositions intended to reduce the risk of occupational and non-professional exposure in France...
February 2015: Bulletin de L'Académie Nationale de Médecine
https://www.readbyqxmd.com/read/27476313/-review-and-perspective-of-a-long-term-follow-up-of-two-cohorts-of-workers-heavily-exposed-to-asbestos
#10
Alain Chamoux
National screening programs for detection of breast, colon and cervical cancers have been set up in France. Occupational cancers are excluded from these programs. Surveillance is left to the initiative of former employees who can initiate post-professional medical monitoring. This study describes an experience of such monitoring organised by the health insurance in collaboration with "victims". The long term follow-up, every two years, of 324 workers directly and heavily exposed to asbestos confirms the high risk of developing lung cancer, mesothelioma or asbestosis, the latter at times rapidly evolving...
February 2015: Bulletin de L'Académie Nationale de Médecine
https://www.readbyqxmd.com/read/27397058/anthophyllite-asbestos-state-of-the-science-review
#11
REVIEW
Shannon H Gaffney, Matthew Grespin, Lindsey Garnick, Derek A Drechsel, Rebecca Hazan, Dennis J Paustenbach, Brooke D Simmons
Anthophyllite is an amphibole form of asbestos historically used in only a limited number of products. No published resource currently exists that offers a complete overview of anthophyllite toxicity or of its effects on exposed human populations. We performed a review focusing on how anthophyllite toxicity was understood over time by conducting a comprehensive search of publicly available documents that discussed the use, mining, properties, toxicity, exposure and potential health effects of anthophyllite...
January 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27325081/comments-on-the-2014-helsinki-consensus-report-on-asbestos
#12
Philip J Landrigan
BACKGROUND: The Finnish Institute of Occupational Health (FIOH) convened an Expert Committee in 2014 to update the 1997 and 2000 Helsinki criteria on asbestos, asbestosis, and cancer. METHODS: The Collegium Ramazzini reviewed the criteria for pathological diagnosis of the diseases caused by asbestos presented in the 2014 Helsinki Consensus Report and compared them with the widely used diagnostic criteria developed in 1982 by the College of American Pathologists and the National Institutes of Occupational Safety and Health (CAP-NIOSH)...
January 2016: Annals of Global Health
https://www.readbyqxmd.com/read/27223586/-idiopatic-pulmonary-fibrosis-news-in-multidisciplinary-diagnostic-and-therapeutic-approaches
#13
Martina Vašáková, Radoslav Matěj
Idiopathic pulmonary fibrosis (IPF) is a primary fibrosing pulmonary process. Due to the ineffectiveness of current therapeutic strategies and unfavorable prognosis, IPF is the most serious example of idiopathic interstitial lung diseases (ILD). Etiology and pathogenesis of this disorder have not been fully clarified yet; but it is anticipated, that the fibroproliferation is caused by the imbalance of reparative and immunologic processes in the genetically predisposed patients. Radiologically and histopathologically, IPF is characterized by specific pattern called usual interstitial pneumonia (UIP), however, this pattern is not fully typical in all cases, and, moreover, it could be seen in other ILD´s, e...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27220441/-the-incidence-of-asbestos-related-diseases-about-on-asbestos-enterprises-in-qingdao-from-1988-to-2014
#14
P P Song, Y Wang, J L Sun, Y Gao, J Liu, Y X Chen
OBJECTIVE: It can provide statistics reference for the prevention and treatment by analysising the status and characteristics related to the asbestos disease of an asbestos products enterprises from 1988 to 2014. METHODS: We have collected the data concerning the case of asbestos-related disease between 1988 and 2014, then the data were arranged, collecteted and analyzed using statistical method. RESULTS: The total of patients is 625 (male: 225, female: 400)...
March 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27043967/carcinoma-of-the-lung-in-the-absence-of-asbestosis-the-value-of-lung-fiber-burden-analysis
#15
Victor L Roggli, Thomas A Sporn
Asbestos is universally recognized as a carcinogen for the lower respiratory tract. However, asbestos is a contributory factor in a small fraction of lung cancers, the vast majority of which are related to cigarette smoking. The challenge for the pathologist is to determine when a lung cancer may be attributed to past asbestos exposure. The finding of asbestosis either clinically or pathologically is a useful marker for such a determination. However, in the absence of asbestosis, it has been suggested that a fiber burden as determined by analytical electron microscopy within the range of asbestosis is sufficient for determination of a causal contribution...
May 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27040844/diffuse-malignant-mesothelioma-and-synchronous-lung-cancer-a-clinicopathological-study-of-18-cases
#16
Kelly J Butnor, Noel A Brownlee, Annabelle Mahar, Elizabeth N Pavlisko, Thomas A Sporn, Victor L Roggli
OBJECTIVES: To examine the clinicopathologic characteristics of individuals with diffuse malignant mesothelioma (DMM) occurring concurrently with lung cancer (LC). MATERIALS AND METHODS: A database of approximately 3800 patients with DMM was reviewed, from which 18 patients (0.5%) who had synchronous LC were identified. The clinicopathologic features, as well as the occupational exposure history and fiber burden analysis data were examined. RESULTS: The patient median age was 68 years (range 58-84 years)...
May 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/26969815/exposure-response-estimate-for-lung-cancer-and-asbestosis-in-a-predominantly-chrysotile-exposed-chinese-factory-cohort
#17
Midori N Courtice, Xiaorong Wang, Sihao Lin, Ignatius Tak Sun Yu, D Wayne Berman, Eiji Yano
BACKGROUND: Cumulative fiber exposures, predominantly chrysotile, were estimated in a Chinese asbestos worker cohort and exposure-response relationships with lung cancer mortality and cumulative incidence of asbestosis were determined. METHODS: Individual time-dependent cumulative exposures were estimated for 577 asbestos workers, followed prospectively for 37 years. Occupational history and smoking data were obtained from company records and personal interviews; vital status and causes of death were ascertained from death registries and hospital records...
May 2016: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/26951736/-proposal-of-an-italian-national-protocol-of-health-surveillance-for-former-asbestos-workers-an-ongoing-project
#18
Luciano Marchiori, Gianluca Marangi, Nicoletta Ballarin, Flavio Valentini, Mauro D'Anna, Paolo Barbina, Alberto Franchi, Giuseppe Mastrangelo
OBJECTIVES: to define an Italian national protocol of post-occupational health surveillance for asbestos workers according to effectiveness, appropriateness, saving, and social utility. DESIGN: data for 1,071 former asbestos workers from several Italian Regions were collected and analysed. For these workers, a retrospective estimate of asbestos exposure was carried out. A cohort study of 1,588 asbestos workers recruited from 2000 onward during statutory health examinations in Veneto and followed-up for lung cancer mortality until December 2010 was executed...
January 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/26951735/-time-trend-in-mesothelioma-and-lung-cancer-risk-in-asbestos-workers-in-italy
#19
Corrado Magnani, Laura Ancona, Antonio Baldassarre, Vittoria Bressan, Tiziana Cena, Elisabetta Chellini, Francesco Cuccaro, Daniela Ferrante, Patrizia Legittimo, Ferdinando Luberto, Alessandro Marinaccio, Stefano Mattioli, Simona Menegozzo, Enzo Merler, Lucia Miligi, Dario Mirabelli, Marina Musti, Enrico Oddone, Venere Pavone, Patrizia Perticaroli, Aldo Pettinari, Roberta Pirastu, Alessandra Ranucci, Elisa Romeo, Orietta Sala, Corrado Scarnato, Stefano Silvestri
This study aims at investigating, in asbestos exposed workers, the time trend of their risk of mesothelioma and of other neoplasm after very long latency and after the cessation of asbestos exposure. We pooled a large number of Italian cohorts of asbestos workers and updated mortality follow-up. The pool of data for statistical analyses includes 51,988 workers, of which 6,058 women: 54.2% was alive at follow-up, 42.6% was dead, and 2.8%was lost. Cause of death is known for 94.3%: 2,548 deaths from lung cancer, 748 frompleural cancer, 173 fromperitoneal cancer, and 434 from asbestosis...
January 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/26788989/multipolar-mitosis-and-aneuploidy-after-chrysotile-treatment-a-consequence-of-abscission-failure-and-cytokinesis-regression
#20
Beatriz Araujo Cortez, Paula Rezende-Teixeira, Sambra Redick, Stephen Doxsey, Glaucia Maria Machado-Santelli
Chrysotile, like other types of asbestos, has been associated with mesothelioma, lung cancer and asbestosis. However, the cellular abnormalities induced by these fibers involved in cancer development have not been elucidated yet. Previous works show that chrysotile fibers induce features of cancer cells, such as aneuploidy, multinucleation and multipolar mitosis. In the present study, normal and cancer derived human cell lines were treated with chrysotile and the cellular and molecular mechanisms related to generation of aneuploid cells was elucidated...
February 23, 2016: Oncotarget
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