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https://www.readbyqxmd.com/read/29667524/optimization-of-the-extraction-of-bioactive-molecules-from-lycium-barbarum-fruits-and-evaluation-of-the-antioxidant-activity-a-combined-study
#1
Chiara Povolo, Alberto Foschini, Giovanni Ribaudo
Novel food, super food, wolfberry, the Himalayan longevity fruit. Several different and, even more, colourful names define the fruits of Lycium barbarum L., one of the most popular food supplements and anti-aging remedies of the recent years. Goji derivatives find application at the interface between food and medicine thanks to the claimed antioxidant and immunomodulatory properties. Aiming at identifying the most effective extraction protocol for processing different goji berries samples (fresh and dried, commercial and from an Italian cultivar), combinations of extractive and analytical techniques were attempted...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29663701/efficacy-and-safety-of-retinaldehyde-0-1-and-0-05-creams-used-to-treat-photoaged-skin-a-randomized-double-blind-controlled-trial
#2
Hyuck Sun Kwon, Ji Hae Lee, Gyong Moon Kim, Jung Min Bae
BACKGROUND: Although topical retinoic acid effectively restores photoaged skin, the associated irritation limits the utility of the material. Retinaldehyde (RAL) is the natural precursor of retinoic acid and can also be used to treat photoaged skin; the safety profile is good. AIMS: To evaluate the efficacy and safety of new anti-aging creams containing RAL at 0.1% and 0.05% used to treat photoaged skin. PATIENTS AND METHODS: We enrolled 40 female Korean volunteers who applied RAL 0...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29623840/fruitless-wolfberry-sprout-extract-rescued-cognitive-deficits-and-attenuated-neuropathology-in-alzheimer-s-disease-transgenic-mice
#3
Shu-Ying Liu, Shuai Lu, Xiao-Lin Yu, Shi-Gao Yang, Wen Liu, Xiang-Meng Liu, Shao-Wei Wang, Jie Zhu, Mei Ji, Dong-Qun Liu, Zi-Ping Zhang, Rui-Tian Liu
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease featured by memory loss, neuroinflammation and oxidative stress. Overproduction or insufficient clearance of Aβ leads to the pathological aggregation and deposition, which is considered the predominant neuropathological hallmark of AD. Therefore, reducing Aβ levels and inhibiting Aβ-induced neurotoxicity are feasible therapeutic strategies for AD treatment. Wolfberry has been traditionally used as a natural antioxidant and anti-aging product...
April 4, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29616249/anti-aging-potential-of-tree-nuts-with-a-focus-on-the-phytochemical-composition-molecular-mechanisms-and-thermal-stability-of-major-bioactive-compounds
#4
REVIEW
Marius Emil Rusu, Ana-Maria Gheldiu, Andrei Mocan, Laurian Vlase, Daniela-Saveta Popa
Tree nuts, complete functional foods, contain macro- and micronutrients of high biological value. These bioactive compounds have a synergistic effect in preventing and delaying many age-related pathologies (e.g. cardiovascular diseases, stroke, type 2 diabetes mellitus, certain types of cancer, and several neurodegenerative diseases). Tree nuts are low in carbohydrates, but they abound in healthy fatty acids, in optimal proportion for a good plasma lipid profile, and are a good source of proteins, rich in proteinogenic amino acids...
April 4, 2018: Food & Function
https://www.readbyqxmd.com/read/29615416/the-drosophila-tgf-beta-activin-like-ligands-dawdle-and-myoglianin-appear-to-modulate-adult-lifespan-through-regulation-of-26s-proteasome-function-in-adult-muscle
#5
Shaughna Langerak, Myung-Jun Kim, Hannah Lamberg, Michael Godinez, Mackenzie Main, Lindsey Winslow, Michael B O'Connor, Changqi C Zhu
The Drosophila Activin signaling pathway employs at least three separate ligands, Activin-β (Actβ), Dawdle (Daw), and Myoglianin (Myo), to regulate several general aspects of fruit fly larval development including cell proliferation, neuronal remodeling, and metabolism. Here we provide experimental evidence indicating that both Daw and Myo are anti-ageing factors in adult fruit flies. Knockdown of Myo or Daw in adult fruit flies reduced mean lifespan, while overexpression of either ligand in adult muscle tissues but not in adipose tissues enhanced mean lifespan...
April 3, 2018: Biology Open
https://www.readbyqxmd.com/read/29605632/long-term-administration-of-pdc-stimulative-lactococcus-lactis-strain-decelerates-senescence-and-prolongs-the-lifespan-of-mice
#6
Tetsu Sugimura, Kenta Jounai, Konomi Ohshio, Hiroaki Suzuki, Takayoshi Kirisako, Yoshihiko Sugihara, Daisuke Fujiwara
The decline in immune function caused by aging increases the risk of infectious diseases, tumorigeneses and chronic inflammation, resulting in accelerating senescence. We previously reported a lactic acid bacteria, Lactococcus lactis strain Plasma (synonym of Lactococcus lactis subsp. lactis JCM 5805, Lc-Plasma), that stimulates plasmacytoid dendritic cells (pDCs), which play a crucial role in phylaxis from viral infection. In this study, we investigated the anti-aging effects of long-term oral administration of Lc-Plasma in a senescence-accelerated mouse strain, SAMP6...
March 29, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29604296/circulating-cd34-and-cd34-vegfr2-progenitor-cells-are-associated-with-klotho-kl-vs-polymorphism
#7
Maria Skrzypkowska, Bartosz Słomiński, Monika Ryba-Stanisławowska, Piotr Gutknecht, Janusz Siebert
BACKGROUND: KLOTHO is a regulator of endothelial cells activity and integrity. It has been described for the first time because of its anti-aging properties. KLOTHO encoding gene is present in many functional variants in humans, including "KL-VS" variant that has been connected with longevity and cardiovascular disease development. Few mechanisms have been proposed to explain these associations, but none of them focused on cells from CD34+ population. The aim of our study was to investigate influence of KLOTHO KL-VS polymorphism on populations of CD34+ and CD34+VEGFR2+ cells...
March 28, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29603432/in-vitro-epidermis-model-mimicking-igf-1-specific-age-related-decline
#8
Carine Mainzer, Noëlle Remoué, Jennifer Molinari, Patricia Rousselle, Carla Barricchello, Juliana C Lago, Pascal Sommer, Dominique Sigaudo-Roussel, Romain Debret
Aging is a complex multifaceted process affecting skin functionality and structure. Several 3D organotypic skin culture models have reproduced aging by inducing replicative senescence, glycation or oxidative stress. Yet, very few models have focused on hormonal aging and especially the insulin-like growth factor 1 (IGF-1) signaling pathway, which has been associated to longevity in animal studies and is necessary in the early stages of skin development. In this study, we built an organotypic epidermis model with targeted IGF-1 receptor knockdown to reproduce some aspects of hormonal aging on skin...
March 30, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29601620/multi-center-double-blind-vehicle-controlled-clinical-trial-of-an-alpha-and-beta-defensin-containing-anti-aging-skin-care-regimen-with-clinical-histopathologic-immunohistochemical-photographic-and-ultrasound-evaluation
#9
Amy Taub, Vivian Bucay, Gregory Keller, Jay Williams, Darius Mehregan
BACKGROUND/OBJECTIVES: Anti-aging strategies utilizing stem cells are in the forefront. Alpha and beta defensins are natural immune peptides that have been shown to activate an LGR6-positive stem cell locus in the hair follicle, identified as the source of most new epidermal cells during acute wound healing. We investigated the ability of biomimetic alpha and beta defensin molecules, supplemented with supportive cosmetic ingredients, formulated into three skin care products, at improving the structure and function of aging skin...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29601618/the-use-of-a-self-occluding-topical-anasthetic-in-daily-practice-a-non-interventional-study
#10
Ravi Jain, Gerardo Moreno Arias, Pablo Naranjo, Max Murison, Jose Luis López Estebaranz, Alina Fratila, Welf Prager, Carlos Guillén Barona, Michael Weidmann, Serge Dahan, Hugues Cartier, Gerhard Sattler, Maurizio Podda
INTRODUCTION: A variety of topical anesthetic creams are available to reduce pain associated with dermatological procedures. Pliaglis is a self-occluding eutectic mixture of lidocaine and tetracaine. STUDY OBJECTIVES: To evaluate the post-marketing safety profile of Pliaglis and efficacy in terms of pain reduction, product satisfaction, and daily practice use prior to pre-defined dermatological procedures. METHODS: A prospective, non-interventional study conducted at 44 sites in four European countries; 581 patients were treated prior to dermatological procedures such as pulsed-dye laser therapy, laser-assisted hair removal, non-ablative laser resurfacing, dermal filler injections, and vascular access...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29600625/-effect-of-microrna-34a-sirt1-p53-signal-pathway-on-notoginsenoside-r%C3%A2-delaying-vascular-endothelial-cell-senescence
#11
Xiao-Hua Lai, Yan Lei, Jing Yang, Cheng-Kui Xiu
This study aimed to investigate the effect of notoginsenoside R₁ in delaying H₂O₂-induced vascular endothelial cell senescence through microRNA-34a/SIRT1/p53 signal pathway. In this study, human umbilical vein endothelial cells(HUVECs) were selected as the study object; the aging model induced by hydrogen peroxide(H₂O₂) was established, with resveratrol as the positive drug. HUVECs were randomly divided into four groups, youth group, senescence model group, notoginsenoside R₁ group and resveratrol group...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29600610/-influence-of-light-on-gene-expression-of-key-synthesis-enzyme-genes-ftanr-and-ftlar-about-proanthocyanidin-in-seeds-of-homologous-plant-of-food-and-medicine-fagopyrum-tataricum
#12
Chun-Li Jiang, Xin-Yao Su, Ya-Chun Xu, Er-Yi Wu, Yu-Hua Shi, Dong Zhang, Qing-Fu Chen, Wei Sun, Jian-Ping Xue
Tartary buckwheat Fagopyrum tataricum is an important medicinal and functional herb due to its rich content of flavonoids in the seeds. F.tataricum exhibited good functions for free radicals scavenging, anti-oxidation, anti-aging activities. Although much genetic knowledge of the synthesis, regulation, accumulation of rutin, the genetic basis of proanthocyanidins(PAs) in tartary buckwheat and their related gene expression changes under different lights(blue, red, far red, ultraviolet light) remain largely unexplored...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29599913/time-dependent-effects-of-late-onset-dietary-intake-of-salidroside-on-lifespan-and-age-related-biomarkers-of-the-annual-fish-nothobranchius-guentheri
#13
Xia Wang, Xiaoyuan Du, Yang Zhou, Su Wang, Feng Su, Shicui Zhang
One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Previous studies have shown that salidroside can protect D-galactose-induced mouse model against aging and a formulation of Rhodiola rosea extracts (SHR-5) containing salidroside increases lifespan of fruit fly. However, direct evidence linking salidroside itself with the observed anti-aging effect in vivo and relevant molecular mechanisms are poorly defined. In this study, we first demonstrated that salidroside exhibited a time-dependent effect, and late-onset long-term salidroside dietary intake extended the lifespan in the annual fish Nothobranchius guentheri ...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29597027/natural-products-with-anti-aging-potential-affected-targets-and-molecular-mechanisms
#14
REVIEW
Cristina-Sorina Cătană, Nikolay Mehterov, Atanas G Atanasov, Ioana Berindan-Neagoe
In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational modification and can also induce the upregulation of autophagy, thus reducing the level of acetyl coenzyme A (AcCoA). In addition, the effect of caloric restriction (CR) on cancer-related chronic inflammation is of great significance in aging...
March 26, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29588426/potential-benefits-of-a-sulfated-resveratrol-derivative-for-topical-application
#15
Marta Correia-da-Silva, Verónica Rocha, Cláudia Marques, Cláudia Deus, Adriana Marques-Carvalho, Paulo Oliveira, Andreia Palmeira, Madalena Pinto, Maria Emília Sousa, José Sousa Lobo, Isabel Almeida
Resveratrol (RSV) is a polyphenolic compound with antioxidant, anti-inflammatory, and anti-aging properties partly associated with sirtuin-1 (SIRT1)-activation in the skin. However, poor water solubility may limit RSV efficacy. This work aimed to clarify the interest of a new synthetic water-soluble RSV derivative (resveratrol glucoside sulfate, RSV-GS) for topical application. Resveratrol glucoside sulfate was synthesized using microwave-assisted sulfation. Cytotoxicity assays were performed with the keratinocyte HaCaT cell line, using MTT reduction, neutral red uptake, Alamar Blue/resazurin reduction, trypan blue exclusion, and measurement of ATP concentration...
March 27, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29581730/the-impact-of-rhodiola-rosea-on-the-gut-microbial-community-of-drosophila-melanogaster
#16
Khachik E Labachyan, Dara Kiani, Evgueni A Sevrioukov, Samuel E Schriner, Mahtab Jafari
Background: The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra , shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola family, Rhodiola crenulata , has previously been shown to confer positive effects on the gut homeostasis of the fruit fly, Drosophila melanogaster. Although, R. rosea has been shown to extend lifespan of many organisms such as fruit flies, worms and yeast, its anti-aging mechanism remains uncertain...
2018: Gut Pathogens
https://www.readbyqxmd.com/read/29577682/-physiological-changes-of-saccharomyces-cerevisiae-during-serial-re-pitching-a-review
#17
Huajian Ding, Jinjing Wang, Jiaqi Zhu, Meiying Zheng, Feiyun Zheng, Yongxian Li, Chengtuo Niu, Chunfeng Liu, Qi Li
The morphological structure and physiological indexes of Saccharomyces cerevisiae have changed during serial re-pitching due to the stress conditions in serial handlings and the cells become aging. It is of great significance to study the physiological changes of S. cerevisiae during serial re-pitching to understand the anti-aging effect of S. cerevisiae. In this paper, the changes of the physiological indexes during re-pitching of yeast are summarized, and based on the analysis of the previous works further research directions are proposed...
March 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29576745/anti-inflamm-ageing-and-or-anti-age-related-disease-emerging-treatments-a-historical-alchemy-or-revolutionary-effective-procedures
#18
REVIEW
Carmela Rita Balistreri
The " long-life elixir " has long represented for humans a dream, a vanity's sin for remaining young and to long survive. Today, because of ageing population phenomenon , the research of antiageing interventions appears to be more important than ever, for preserving health in old age and retarding/or delaying the onset of age-related diseases. A hope is given by experimental data, which evidence the possibility of retarding ageing in animal models. In addition, it has been also demonstrated in animal life-extending studies not only the possibility of increasing longevity but also the ability to retard the onset of age-related diseases...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29575469/the-effects-of-graded-caloric-restriction-xii-comparison-of-mouse-to-human-impact-on-cellular-senescence-in-the-colon
#19
Luigi Fontana, Sharon E Mitchell, Boshi Wang, Valeria Tosti, Thijmen van Vliet, Nicola Veronese, Beatrice Bertozzi, Dayna S Early, Parcival Maissan, John R Speakman, Marco Demaria
Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear...
March 25, 2018: Aging Cell
https://www.readbyqxmd.com/read/29573298/anti-ageing-effect-of-red-ginseng-revealed-by-urinary-metabonomics-using-rrlc-q-tof-ms
#20
Jinghui Sun, Chuanxin Jiao, Yue Ma, Jianguang Chen, Wei Wu, Shuying Liu
INTRODUCTION: Red ginseng (RG) is one of the main processed products of the roots and rhizomes of Panax ginseng C.A. Meyer and is used for anti-ageing. But how metabonomic influences of RG on the progress of ageing are less researched. OBJECTIVE: A metabonomic method was developed to study the characters of the ageing process and the effects of total ginsenosides of red ginseng (TGRG) on the progress of ageing. METHODS: Urine samples from four different ages (4, 12, 18 and 24 months old) of rats and interference after TGRG were analysed by rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (RRLC-Q-TOF-MS) and multivariate statistical analysis were performed for the pattern recognition and characteristic metabolites identification...
March 24, 2018: Phytochemical Analysis: PCA
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