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https://www.readbyqxmd.com/read/28108179/symptomatic-treatment-of-cough-among-adult-patients-with-lung-cancer-chest-guidelines-and-expert-panel-report
#1
Alex Molassiotis, Jaclyn A Smith, Peter Mazzone, Fiona Blackhall, Richard S Irwin
BACKGROUND: Cough among patients with lung cancer is a common but often undertreated symptom. We have used a recent Cochrane systematic review, among other sources of evidence, to update the recommendations and suggestions of the CHEST 2006 guideline on this topic. METHODS: The American College of Chest Physicians (CHEST) methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. The Expert Cough Panel based their recommendations on data from the Cochrane systematic review on the topic, uncontrolled studies, case studies, and the clinical context...
January 17, 2017: Chest
https://www.readbyqxmd.com/read/28108122/-fast-methods-of-fungal-and-bacterial-identification-maldi-tof-mass-spectrometry-chromogenic-media
#2
María Siller-Ruiz, Sara Hernández-Egido, Fernando Sánchez-Juanes, José Manuel González-Buitrago, Juan Luis Muñoz-Bellido
MALDI-TOF mass spectrometry is now a routine resource in Clinical Microbiology, because of its speed and reliability in the identification of microorganisms. Its performance in the identification of bacteria and yeasts is perfectly contrasted. The identification of mycobacteria and moulds is more complex, due to the heterogeneity of spectra within each species. The methodology is somewhat more complex, and expanding the size of species libraries, and the number of spectra of each species, will be crucial to achieve greater efficiency...
January 17, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28107437/hyperventilation-with-maintenance-of-isocapnia-an-old-new-method-in-carbon-monoxide-intoxication
#3
Jacek Sein Anand, Daria Schetz, Wojciech Waldman, Marek Wiśniewski
INTRODUCTION: Exposure to carbon monoxide (CO) is among the most common causes of acute and chronic poisonings worldwide. The crucial point of treatment of such acute poisonings is to eliminate CO from the body as fast as possible. There are currently two approaches to the management of the CO intoxication: hyperbaric oxygen therapy (HOT) and normobaric oxygen therapy (NOT). HOT is highly effective and capable of achieving the CO elimination half-time (T½) as low as 15 minutes. Unfortunately this method is expensive and not always readily available...
2017: PloS One
https://www.readbyqxmd.com/read/28104362/use-of-management-pathways-or-algorithms-in-children-with-chronic-cough-chest-guideline-and-expert-panel-report
#4
Anne B Chang, John J Oppenheimer, Miles M Weinberger, Bruce K Rubin, Kelly Weir, Cameron C Grant, Richard S Irwin
BACKGROUND: Using management algorithms or pathways potentially improves clinical outcomes. We undertook systematic reviews to examine various aspects in the generic approach (use of cough algorithms and tests) to the management of chronic cough in children (aged ≤14-years) based on key questions using the PICO format. METHODS: We used the CHEST expert cough panel's protocol for the systematic reviews and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework...
January 16, 2017: Chest
https://www.readbyqxmd.com/read/28090083/kidney-disease-and-obesity-epidemiology-mechanisms-and-treatment
#5
REVIEW
Niels Olsen Saraiva Câmara, Kunitoshi Iseki, Holly Kramer, Zhi-Hong Liu, Kumar Sharma
The theme of World Kidney Day 2017 is 'kidney disease and obesity: healthy lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five leading researchers to describe changes in the epidemiology of obesity-related kidney disease, advances in current understanding of the mechanisms and current approaches to the management of affected patients. The researchers also highlight new advances that could lead to the development of novel treatments and identify areas in which further basic and clinical studies are needed...
January 16, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28089118/occupational-lung-diseases-from-old-and-novel-exposures-to-effective-preventive-strategies
#6
REVIEW
Paul Cullinan, Xavier Muñoz, Hille Suojalehto, Raymond Agius, Surinder Jindal, Torben Sigsgaard, Anders Blomberg, Denis Charpin, Isabella Annesi-Maesano, Mridu Gulati, Yangho Kim, Arthur L Frank, Metin Akgün, David Fishwick, Rafael E de la Hoz, Subhabrata Moitra
Occupational exposure is an important, global cause of respiratory disease. Unlike many other non-communicable lung diseases, the proximal causes of many occupational lung diseases are well understood and they should be amenable to control with use of established and effective approaches. Therefore, the risks arising from exposure to silica and asbestos are well known, as are the means of their prevention. Although the incidence of occupational lung disease has decreased in many countries, in parts of the world undergoing rapid economic transition and population growth-often with large informal and unregulated workforces-occupational exposures continue to impose a heavy burden of disease...
January 6, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28088602/aggressive-surgical-approach-to-the-management-of-neuroendocrine-tumors-a-report-of-1-000-surgical-cytoreductions-by-a-single-institution
#7
Eugene A Woltering, Brianne A Voros, David T Beyer, Yi-Zarn Wang, Ramcharan Thiagarajan, Pamela Ryan, Anne Wright, Robert A Ramirez, M Jennifer Ricks, J Philip Boudreaux
BACKGROUND: Neuroendocrine tumors (NETs) are rare neoplasms. Our group has treated over 2,000 NET patients and has performed over 1,000 surgical cytoreductive procedures. STUDY DESIGN: Records of 834 NET patients who underwent surgical cytoreduction at our institution were reviewed. Demographic information, intraoperative findings, extent of disease, complications, and survival rates were calculated. RESULTS: 800 patients underwent 1,001 cytoreductive surgeries...
January 11, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28087591/clinical-trials-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis-what-we-have-learnt-so-far-and-what-we-still-have-to-learn
#8
Divi Cornec, Emilie Cornec-Le Gall, Ulrich Specks
The prognosis of the antineutrophil cytoplasmic antibody associated vasculitides (AAV), microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA), has been fundamentally improved over the last five decades by the use of glucocorticoids and immunosuppressants, turning them from consistently fatal diseases into chronic conditions. The long-term course is now largely determined by the frequency of disease flares and by accruing damage caused by disease activity and treatment-related comorbidities...
January 12, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28087101/current-management-of-low-risk-differentiated-thyroid-cancer-and-papillary-microcarcinoma
#9
V D Tarasova, R M Tuttle
Each year, the proportion of thyroid cancer patients presenting with low risk disease is increasing. Moreover, the definition of low risk thyroid cancer is expanding and several histological subtypes beyond papillary microcarcinomas are now classified as low risk disease. This shift in the landscape of thyroid cancer presentation is forcing clinicians to critically re-evaluate whether or not traditional management paradigms that were effective in treating intermediate and high risk disease are applicable to these low risk patients...
January 10, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28086848/using-intervention-mapping-to-develop-the-parents-as-agents-of-change-pac-%C3%A2-intervention-for-managing-pediatric-obesity
#10
Geoff D C Ball, Aislin R Mushquash, Rachel A Keaschuk, Kathryn A Ambler, Amanda S Newton
BACKGROUND: Pediatric obesity has become increasingly prevalent over recent decades. In view of the psychosocial and physical health risks, and the high likelihood that children with obesity will grow to become adults with obesity, there is a clear need to develop evidence-based interventions that can be delivered in the health care system to optimize the health and well-being of children with obesity and their families. The aim of this paper is to describe the development, implementation, and planned evaluation of a parent-based weight management intervention designed for parents of 8-12 year olds with obesity...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28080207/laparoscopic-gastropleural-fistula-repair-a-minimally-invasive-solution-for-a-complex-problem
#11
Ran B Luo, Shanglei Liu, Jonathan C DeLong, Garth R Jacobsen, Bryan J Sandler, Santiago Horgan
INTRODUCTION: Gastropleural fistula (GPF) is a complex pathology that can present as a result of surgery, trauma, peptic ulcer disease, malignancies, radiation, or chemotherapy. Management typically includes endoscopic or surgical intervention along with intraabdominal or intrathoracic drainage of pre-existing infection. Traditionally, surgical approaches have been through exploratory laparotomy or thoracotomy, subjecting already ill patients to additional morbidity. CASE REPORT: We describe and demonstrate a laparoscopic minimally invasive approach to the management of a GPF with a wedge resection of the stomach, along with a review of the current literature regarding GPF treatment...
January 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28078983/cutaneous-larva-migrans
#12
Alexander K C Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans. METHODS: A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans"...
January 10, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28078079/looking-forward-to-new-targeted-treatments-for-chronic-spontaneous-urticaria
#13
REVIEW
Emek Kocatürk, Marcus Maurer, Martin Metz, Clive Grattan
The introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease. But there is still a hard core of patients who do not tolerate or benefit from existing therapies and who require effective treatment. Novel approaches include the use of currently available drugs off-licence, investigational drugs currently undergoing clinical trials and exploring the potential for therapies directed at pathophysiological targets in CSU...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28076687/parent-and-family-processes-related-to-adhd-management-in-ethnically-diverse-youth
#14
Cynthia P Paidipati, Bridgette Brawner, Ricardo Eiraldi, Janet A Deatrick
BACKGROUND: Previous research has shown major disparities in attention deficit hyperactivity disorder (ADHD) for diverse youth across America. We do not fully understand, however, how parent and family processes are related to the identification, care-seeking approaches, treatment preferences, and engagement with care systems and services for youth with ADHD. OBJECTIVES: The present study aimed to explore parent and family processes related to the management of ADHD in racially and ethnically diverse youth...
January 1, 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/28074632/gene-expression-profiles-of-the-southern-house-mosquito-culex-quinquefasciatus-during-exposure-to-permethrin
#15
William R Reid, Lee Zhang, Youhui Gong, Ting Li, Nannan Liu
Insecticide resistance is a major obstacle to the management of disease-vectoring mosquitoes worldwide. The genetic changes and detoxification genes involved in insecticide resistance have been extensively studied in populations of insecticide-resistant, however few studies have focused on the resistance genes up-regulated upon insecticide exposure and the possible regulation pathways involved in insecticide resistance. To characterize the changes in gene expression during insecticide exposure, and to investigate the possible connection of known regulation pathways with insecticide resistance, we conducted RNA-Seq analysis of a highly-permethrin resistant strain of Culex quinquefasciatus following permethrin exposure...
January 10, 2017: Insect Science
https://www.readbyqxmd.com/read/28074550/treatment-strategy-for-urinary-frequency-in-women
#16
Ching-Hung Hsieh, Tsung-Hsien Su
The purpose of this paper is to discuss the differential diagnosis of the underlying etiologies of urinary frequency and the treatment strategies for urinary frequency in women. Urinary frequency is a symptom, a sign, and a condition of uncertainty and of multifactorial cause. Common causes of urinary frequency include psychosocial, medical, sexual, urological, gynecologic, endocrine, and pharmacological in origin. Hence, treatment of symptoms and possible cures need a high-level plan or strategy to overcome the multifactorial etiology...
January 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28074472/cost-evaluation-of-irinotecan-related-toxicities-associated-with-the-ugt1a1-28-patient-genotype
#17
R Roncato, E Cecchin, M Montico, E De Mattia, L Giodini, A Buonadonna, V Solfrini, F Innocenti, G Toffoli
The adoption of a pre-emptive UGT1A1*28 genotyping to increase irinotecan safety in clinical practice is still limited. This is the first actual study of costs associated to the management of irinotecan-related toxicity, and their association with UGT1A1*28 genotype. A retrospective analysis of the cost of toxicity management was conducted on 243 metastatic colorectal cancer patients enrolled in a clinical trial and treated with standard of care FOLFIRI. The mean predicted cost per patient was higher for *28/*28 (4,886€), versus *1/*1 (812€), (regression coefficient 1...
January 11, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28070747/enhanced-bulbar-function-in-amyotrophic-lateral-sclerosis-the-nuedexta-treatment-trial
#18
Richard Smith, Erik Pioro, Kathleen Myers, Michael Sirdofsky, Kimberly Goslin, Gregg Meekins, Hong Yu, James Wymer, Merit Cudkowicz, Eric A Macklin, David Schoenfeld, Gary Pattee
The goal of this randomized, blinded, crossover clinical trial was to determine whether Nuedexta (dextromethorphan and quinidine) enhanced speech, swallowing, and salivation in patients with ALS. Sixty patients with amyotrophic lateral sclerosis (ALS) received either Nuedexta or placebo for 28 to 30 days, followed by a 10 to 15-day washout period. Subsequently, patients were switched to the opposite treatment arm for the remaining days of the trial. The primary endpoint was a reduction in the self-report Center for Neurologic Study Bulbar Function Scale (CNS-BFS) score...
January 9, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28061987/management-of-multiple-myeloma-in-resource-constrained-settings
#19
REVIEW
Lalit Kumar, Ranjit Kumar Sahoo
The prognosis of patients with multiple myeloma (MM) has improved significantly in the past two decades. This is attributed to use of novel agents for induction, high-dose chemotherapy and autologous stem cell transplantation (ASCT), maintenance therapy, and improved supportive care. Currently, evidence-based management guidelines/recommendations developed by International societies/groups are being followed partially in low-resource settings. Lack of quality diagnostics (eg, cytogenetics/fluorescence in situ hybridization (FISH), serum free light chains), novel therapeutics, and trained manpower, and limited financial resources are key challanges...
December 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/28057983/role-of-extracorporeal-shock-wave-therapy-in-management-of-peyronie-s-disease-a-preliminary-report
#20
Rajendra Kashinath Shimpi, Ravi Jineshkumar Jain
INTRODUCTION: Peyronie's Disease (PD) is a disease causing psycho social trauma to the patient. Multiple treatment options are available with variable results. Extra Corporeal Shock Wave Therapy (ESWT) is a new insight into the non invasive modality of management. It focuses on the mechanism of inducing angiogenesis in the penile cavernous tissue. MATERIALS AND METHODS: The aim of the study is to determine the role of ESWT in the management of PD. The objectives include demonstrating the improvement in mean International Index of Erectile Function Score (IIEFS), improvement in pain score by Visual Analogue Scale (VAS), change in cavernosal artery flow on colour penile Doppler, reduction in plaque size, and improvement in penile curvature degree after the therapy...
October 2016: Urology Annals
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