keyword
https://read.qxmd.com/read/38535555/detection-of-meca-genes-in-hospital-acquired-mrsa-and-sosa-strains-associated-with-biofilm-formation
#1
JOURNAL ARTICLE
Rosa González-Vázquez, María Guadalupe Córdova-Espinoza, Alejandro Escamilla-Gutiérrez, María Del Rocío Herrera-Cuevas, Raquel González-Vázquez, Ana Laura Esquivel-Campos, Laura López-Pelcastre, Wendoline Torres-Cubillas, Lino Mayorga-Reyes, Felipe Mendoza-Pérez, María Angélica Gutiérrez-Nava, Silvia Giono-Cerezo
Methicillin-resistant (MR) Staphylococcus aureus (SA) and others, except for Staphylococcus aureus (SOSA), are common in healthcare-associated infections. SOSA encompass largely coagulase-negative staphylococci, including coagulase-positive staphylococcal species. Biofilm formation is encoded by the icaADBC operon and is involved in virulence. mecA encodes an additional penicillin-binding protein (PBP), PBP2a, that avoids the arrival of β-lactams at the target, found in the staphylococcal cassette chromosome mec (SCC mec )...
February 28, 2024: Pathogens
https://read.qxmd.com/read/38534690/chestnut-honey-is-effective-against-mixed-biofilms-at-different-stages-of-maturity
#2
JOURNAL ARTICLE
Regina Koloh, Viktória L Balázs, Lilla Nagy-Radványi, Béla Kocsis, Erika Beáta Kerekes, Marianna Kocsis, Ágnes Farkas
The irresponsible overuse of antibiotics has increased the occurrence of resistant bacterial strains, which represents one of the biggest patient safety risks today. Due to antibiotic resistance and biofilm formation in bacteria, it is becoming increasingly difficult to suppress the bacterial strains responsible for various chronic infections. Honey was proven to inhibit bacterial growth and biofilm development, offering an alternative solution in the treatment of resistant infections and chronic wounds. Our studies included chestnut honey, valued for its high antibacterial activity, and the bacteria Pseudomonas aeruginosa , methicillin-resistant Staphylococcus aureus , and S...
March 13, 2024: Antibiotics
https://read.qxmd.com/read/38534672/antibacterial-effect-of-eight-essential-oils-against-bacteria-implicated-in-bovine-mastitis-and-characterization-of-primary-action-mode-of-thymus-capitatus-essential-oil
#3
JOURNAL ARTICLE
Chedia Aouadhi, Ahlem Jouini, Karima Maaroufi, Abderrazak Maaroufi
During the current investigation, eight essential oils (EOs) were tested for their antimicrobial activity against six species, belonging to the genus of staphylococcus , multi-resistant to antibiotics ( S. epidermidis , S. cohni , S. wareneri , S. scuiri , S. chromogenes , S. pasteuri ), three methicillin-resistant Staphylococcus aureus strains (MRSA) and two strains of Escherichia coli, producing extended-spectrum β-lactamase (ESBL) responsible for bovine mastitis. Our results indicated that the antimicrobial activities of eight EOs varied significantly among the types of EOs and bacterial species...
March 5, 2024: Antibiotics
https://read.qxmd.com/read/38534663/polylactic-glycolic-acid-mediated-delivery-of-plectasin-derivative-nz2114-in-staphylococcus-epidermidis-biofilms
#4
JOURNAL ARTICLE
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Yinhua Huang, Jianhua Wang
Antimicrobial peptides (AMPs) are antibiotic candidates; however, their instability and protease susceptibility limit clinical applications. In this study, the polylactic acid-glycolic acid (PLGA)-polyvinyl alcohol (PVA) drug delivery system was screened by orthogonal design using the double emulsion-solvent evaporation method. NZ2114 nanoparticles (NZ2114-NPs) displayed favorable physicochemical properties with a particle size of 178.11 ± 5.23 nm, polydispersity index (PDI) of 0.108 ± 0.10, ζ potential of 4...
February 29, 2024: Antibiotics
https://read.qxmd.com/read/38534661/new-insights-into-cutaneous-asepsis-synergism-between-pfaffia-and-rosemary-extracts
#5
JOURNAL ARTICLE
Diego Garcia Miranda, Florence Carrouel, Tatiane Cristina Alberti Silva, Mariana Cafalchio Rozzatto, Amjad Abu Hasna, Carlos Eduardo Rocha Santos, Flavia Villaça Morais, Luciane Dias de Oliveira, Lucas de Paula Ramos
(1) Background: In hospitals, medical and dental clinics, antiseptics or disinfectants play an essential role in the control of nosocomial infections. This study aimed to evaluate R. officinalis and P. paniculata glycolic extracts regarding: (I) their antimicrobial action on planktonic and biofilm (monotypic and cutaneous biofilm model- S. aureus , S. epidermidis and C. acnes ); and (II) their cytotoxicity on human keratinocytes (HaCaT). (2) Methods: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were performed (CLSI protocol M7-A6 and M11-A8)...
February 28, 2024: Antibiotics
https://read.qxmd.com/read/38529473/spectrum-and-antibiotic-sensitivity-of-bacterial-keratitis-a-retrospective-analysis-of-eight-years-in-a-tertiary-referral-hospital-in-southwest-china
#6
JOURNAL ARTICLE
Rui-Qin Guo, Ji Yang, Ya-Bin Yang, Ya-Nan Chen, Yu-Yuan Xiao, Ping Xiang, Meng-Jie Dong, Min-Fang He, Yin-Ting Wang, Yun-Ling Xiao, Hong-Qin Ke, Hai Liu
PURPOSE: The objective of this study was to investigate the epidemiological characteristics, distribution of isolates, prevailing patterns, and antibiotic susceptibility of bacterial keratitis (BK) in a Tertiary Referral Hospital located in Southwest China. METHODS: A retrospective analysis was conducted on 660 cases of bacterial keratitis occurring between January 2015 and December 2022. The demographic data, predisposing factors, microbial findings, and antibiotic sensitivity profiles were examined...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38525229/microbiological-analysis-of-skin-lesions-of-cod-gadus-morhua-from-the-southern-part-of-the-baltic-sea
#7
JOURNAL ARTICLE
Agnieszka Pękala-Safińska, Katarzyna Nadolna-Ałtyn, Mirosław Różycki, Ewa Paździor, Tomasz Cencek, Magdalena Podolska
INTRODUCTION: Since the middle of the 1980s, severe skin disorders have been observed in Baltic cod ( Gadus morhua ) each year. Available data on the spectrum of bacteria isolated from the clinical cases being limited, and evaluation of the microbial background of fish skin lesions being useful, a bacteriological examination has been undertaken. MATERIAL AND METHODS: A total of 1,381 cod were caught during two voyages of the Baltica research vessel in the Polish exclusive economic zone of the southern Baltic Sea...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38525037/diversity-and-antimicrobial-activity-of-the-tropical-ant-derived-actinomycetes-isolated-from-thailand
#8
JOURNAL ARTICLE
Tuangrat Tunvongvinis, Weeyawat Jaitrong, Yudthana Samung, Somboon Tanasupawat, Wongsakorn Phongsopitanun
Antibiotic resistance is one of the most important global healthcare challenges and is responsible for the mortality of millions of people worldwide every year. It is a crisis attributed to misuse of antibiotics and a lack of new drug development. Actinomycetes constitute a group of Gram-positive bacteria known for their distinctive high guanine-cytosine (G+C) content in their genomic DNA. These microorganisms are widely recognized for their capability to generate a wide range of secondary metabolites with diverse biological activities...
2024: AIMS Microbiology
https://read.qxmd.com/read/38523156/using-novel-micropore-technology-combined-with-artificial-intelligence-to-differentiate-staphylococcus-aureus-and-staphylococcus-epidermidis
#9
JOURNAL ARTICLE
Ayumi Morimura, Masateru Taniguchi, Hiroyasu Takei, Osamu Sakamoto, Norihiko Naono, Yukihiro Akeda, Daisuke Onozuka, Jumpei Yoshimura, Kazunori Tomono, Satoshi Kutsuna, Shigeto Hamaguchi
Methods for identifying bacterial pathogens are broadly categorised into conventional culture-based microbiology, nucleic acid-based tests, and mass spectrometry. The conventional method requires several days to isolate and identify bacteria. Nucleic acid-based tests and mass spectrometry are relatively rapid and reliable, but they require trained technicians. Moreover, mass spectrometry requires expensive equipment. The development of a novel, inexpensive, and simple technique for identifying bacterial pathogens is needed...
March 24, 2024: Scientific Reports
https://read.qxmd.com/read/38511104/comparison-between-moxifloxacin-and-chloramphenicol-for-the-treatment-of-bacterial-eye-infections
#10
JOURNAL ARTICLE
Valentina Gentili, Giovanni Strazzabosco, Rossella Spena, Sabrina Rizzo, Silvia Beltrami, Giovanna Schiuma, Andrea Alogna, Roberta Rizzo
BACKGROUND: Moxifloxacin is a bactericidal methoxyquinolone used for the treatment of conjunctivitis and prophylactic therapy in cataract and refractive surgeries. Chloramphenicol is a bacteriostatic organochlorine introduced into clinical practice in 1948 and used mainly in topical preparations because of its known toxicity. OBJECTIVES: The study aimed to evaluate the in vitro antibacterial effect and the ocular cytotoxicity of these broad-spectrum antibiotics...
2024: Current Therapeutic Research, Clinical and Experimental
https://read.qxmd.com/read/38510256/corrigendum-inflammatory-response-against-staphylococcus-aureus-via-intracellular-sensing-of-nucleic-acids-in-keratinocytes
#11
Quang Vinh Ngo, Larissa Faass, Aline Sähr, Dagmar Hildebrand, Tatjana Eigenbrod, Klaus Heeg, Dennis Nurjadi
[This corrects the article DOI: 10.3389/fimmu.2022.828626.].
2024: Frontiers in Immunology
https://read.qxmd.com/read/38507790/co-immobilization-of-ciprofloxacin-and-chlorhexidine-as-a-broad-spectrum-antimicrobial-dual-drug-coating-for-poly-vinyl-chloride-pvc-based-endotracheal-tubes
#12
JOURNAL ARTICLE
Diana Filipa Alves, Maria Olívia Pereira, Susana Patrícia Lopes
The endotracheal tube (ETT) affords support for intubated patients, but the increasing incidence of ventilator-associated pneumonia (VAP) is jeopardizing its application. ETT surfaces promote (poly)microbial colonization and biofilm formation, with a heavy burden for VAP. Devising safe, broad-spectrum antimicrobial materials to tackle the ETT bioburden is needful. Herein, we immobilized ciprofloxacin (CIP) and/or chlorhexidine (CHX), through polydopamine (pDA)-based functionalization, onto poly(vinyl chloride) (PVC) surfaces...
March 20, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38507272/comparison-of-the-in-vitro-activities-of-delafloxacin-and-comparators-against-staphylococcus-epidermidis-clinical-strains-involved-in-osteoarticular-infections-a-criogo-multicentre-retrospective-study
#13
JOURNAL ARTICLE
E Tessier, L Ruffier d'Epenoux, M F Lartigue, L Chaufour, C Plouzeau-Jayle, R Chenouard, F Guérin, D Tandé, C Lamoureux, P Bémer, S Corvec
OBJECTIVES: Staphylococcus epidermidis bone and joint infections (BJIs) on material are often difficult to treat. The activity of delafloxacin has not yet been studied on S. epidermidis in this context. The aim of this study was to assess its in vitro activity compared with other fluoroquinolones, against a large collection of S. epidermidis clinical strains. METHODS: We selected 538 S. epidermidis strains isolated between January 2015 and February 2023 from six French teaching hospitals...
March 20, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38505856/improving-activity-of-new-arylurea-agents-against-multidrug-resistant-and-biofilm-producing-staphylococcus-epidermidis
#14
JOURNAL ARTICLE
Vittorio Canale, Iwona Skiba-Kurek, Karolina Klesiewicz, Monika Papież, Marlena Ropek, Bartosz Pomierny, Kamil Piska, Paulina Koczurkiewicz-Adamczyk, Joanna Empel, Elżbieta Karczewska, Paweł Zajdel
Multidrug-resistant (MDR) strains of Staphylococcus epidermidis ( S. epidermidis ), prevalent in hospital environments, contribute to increased morbidity and mortality, especially among newborns, posing a critical concern for neonatal sepsis. In response to the pressing demand for novel antibacterial therapies, we present findings from synthetic chemistry and structure-activity relationship studies focused on arylsulfonamide/arylurea derivatives of aryloxy[1-(thien-2-yl)propyl]piperidines. Through bioisosteric replacement of the sulfonamide fragment with a urea moiety, compound 25 was identified, demonstrating potent bacteriostatic activity against clinical multidrug-resistant S...
March 14, 2024: ACS Medicinal Chemistry Letters
https://read.qxmd.com/read/38504752/incidence-of-blood-culture-related-sepsis-in-neonates-and-antibiotics-sensitivity-of-implicated-organisms-in-a-secondary-healthcare-facility-in-ghana
#15
JOURNAL ARTICLE
Francis K Wuni, Margaret W Kukeba, Kwashie S N Dzotsi, Abu Osman, Patrick Atobrah, Rasheed Ofosu-Poku
OBJECTIVE: We determined the incidence of blood culture-related sepsis, causative bacteria, and antibiotics sensitivity among newborn babies with suggestive signs of sepsis admitted at the Upper East Regional Hospital in Bolgatanga, Ghana. DESIGN: Prospective cross-sectional study. SETTING: Newborn Care Unit of the Upper East Regional Hospital, Bolgatanga. PARTICIPANTS: Neonates admitted to the Newborn Care Unit from August 2019 to August 2020 with signs of sepsis...
June 2023: Ghana Medical Journal
https://read.qxmd.com/read/38504751/effects-of-chloramphenicol-povidone-iodine-1-and-5-eye-drops-on-the-colonisation-of-conjunctival-flora-in-patients-undergoing-cataract-surgery
#16
RANDOMIZED CONTROLLED TRIAL
Nasrin Tofighi, Mohsen Gohari, Maryam Sadeh, Hosein Fallahzadeh, Fatemeh Jabinian
OBJECTIVES: the aim was to compare 2 drops of either 5% chloramphenicol, 1% povidone-iodine or 5% povidone-iodine before cataract surgery on reducing the colonisation of bacterial flora in the conjunctiva. DESIGN: This was a double-blind, randomised clinical trial study. SETTING: Patients referred to Shahid Sadoughi Hospital in Yazd, Iran, for cataract surgery were studied. PARTICIPANTS: Totally 260 patients were enrolled...
June 2023: Ghana Medical Journal
https://read.qxmd.com/read/38501828/differentiation-of-keratinocytes-or-exposure-to-type-2-cytokines-diminishes-s-aureus-internalization
#17
JOURNAL ARTICLE
Alexis R Morgenstern, Liam F Peterson, Kimberly A Arnold, Matthew G Brewer
Staphylococcus aureus is a leading cause of skin and soft tissue infections. Colonization by this bacterium is increased in individuals with chronic cutaneous diseases such as atopic dermatitis, psoriasis, and bullous pemphigoid. The greater abundance of S. aureus on the skin of subjects with atopic dermatitis in particular has been linked to recurrent cutaneous infections. The primary cell type of the epidermal layer of the skin is the keratinocyte, and it is thought that S. aureus internalized in keratinocytes associates with an increased incidence of skin infections...
March 19, 2024: MSphere
https://read.qxmd.com/read/38493003/clinical-impact-of-vancomycin-mic-on-outcomes-in-patients-with-coagulase-negative-staphylococcal-bacteremia
#18
JOURNAL ARTICLE
Wade Wheat, Brenda Simiyu, Gabriela Andonie, Lillian Bellfi
PURPOSE: Coagulase-negative staphylococci (CoNS) are Gram-positive organisms that are a known component of normal skin flora and the most common cause of nosocomial bacteremia. For CoNS species, the vancomycin MIC breakpoint for susceptibility set by the Clinical and Laboratory Standards Institute is ≤4 µg/mL. There has been published reports of vancomycin heteroresistance in CoNS with vancomycin MICs of 2 to 4 µg/mL. The aim of this retrospective cohort analysis was to assess the clinical impact of vancomycin MICs <2 µg/mL versus ≥2 µg/mL in adult patients with CoNS bloodstream infections...
March 15, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38492739/evaluation-of-two-commercial-broth-microdilution-systems-for-dalbavancin-susceptibility-testing-of-mrsa-and-other-resistant-gram-positive-cocci
#19
JOURNAL ARTICLE
Ilaria Baccani, Alberto Antonelli, Sara Cuffari, Caterina Ferretti, Tommaso Giani, Gian Maria Rossolini
OBJECTIVES: This study aims to evaluate two commercial broth microdilution (BMD) systems, E1-185-100 (Merlin) and FDANDPF (ThermoFisher) for dalbavancin susceptibility testing in comparison with reference broth microdilution assay. METHODS: Study collection was composed of 200 nonreplicate multidrug-resistant Gram-positive cocci of clinical origin, including 180 methicillin-resistant Staphylococcus aureus, 10 vancomycin resistant enterococci, 7 linezolid resistant Staphylococcus epidermidis, and 3 methicillin-resistant coagulase negative staphylococci...
March 14, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38490424/patient-derived-pathogenic-microbe-deposition-enhances-exposure-risk-in-pediatric-clinics
#20
JOURNAL ARTICLE
Wan Wang, Zongyao Qiu, Hui Li, Xiaorong Wu, Ying Cui, Lixiang Xie, Bozhen Chang, Peipei Li, Hong Zeng, Tao Ding
Healthcare-associated infections (HAIs) pose significant risks to pediatric patients in outpatient settings. To prevent HAIs, understanding the sources and transmission routes of pathogenic microorganisms is crucial. This study aimed to identify the sources of opportunistic bacterial pathogens (OBPs) in pediatric outpatient settings and determine their transmission routes. Furthermore, assessing the public health risks associated with the core OBPs is important. We collected 310 samples from various sites in pediatric outpatient areas and quantified the bacteria using qPCR and CFU counting...
March 13, 2024: Science of the Total Environment
keyword
keyword
11739
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.