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https://www.readbyqxmd.com/read/28196255/effect-of-2-years-of-treatment-with-sublingual-grass-pollen-immunotherapy-on-nasal-response-to-allergen-challenge-at-3-years-among-patients-with-moderate-to-severe-seasonal-allergic-rhinitis-the-grass-randomized-clinical-trial
#1
Guy W Scadding, Moises A Calderon, Mohamed H Shamji, Aarif O Eifan, Martin Penagos, Florentina Dumitru, Michelle L Sever, Henry T Bahnson, Kaitie Lawson, Kristina M Harris, Audrey G Plough, Joy Laurienzo Panza, Tielin Qin, Noha Lim, Nadia K Tchao, Alkis Togias, Stephen R Durham
Importance: Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. Objective: To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placebo, provides improved nasal response to allergen challenge at 3-year follow-up...
February 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28160984/the-2016-lewis-h-wright-memorial-lecture-america-s-doctor-anaesthetists-1862-1936-turning-a-tide-of-asphyxiating-waves
#2
George S Bause
Laughing-gas showman G.Q. Colton franchised dental extraction under 100% nitrous oxide in many large American cities before popularizing the practice with French Imperial Court dentist T.W. Evans in France and then England. Chicago dentist Z. Rogers helped surgeon E. Andrews oxygenate nitrous oxide, with neither man changing significantly the clinical practices of others. London's F.W. Hewitt and Pittsburgh's S.J. Hayes oxygenated anesthetics with greater clinical impact. By 1920, E.I. McKesson had publicized his practice of secondary saturation with bursts of 100% nitrous oxide to relax musculature in anesthetized patients...
January 2017: Journal of Anesthesia History
https://www.readbyqxmd.com/read/28137745/multiple-introductions-and-recent-spread-of-the-emerging-human-pathogen-mycobacterium-ulcerans-across-africa
#3
Koen Vandelannoote, Conor J Meehan, Miriam Eddyani, Dissou Affolabi, Delphin Mavinga Phanzu, Sara Eyangoh, Kurt Jordaens, Françoise Portaels, Kirstie Mangas, Torsten Seemann, Laurent Marsollier, Estelle Marion, Annick Chauty, Jordi Landier, Arnaud Fontanet, Herwig Leirs, Timothy P Stinear, Bouke C de Jong
Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of M. ulcerans by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa...
January 30, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28130063/effects-of-control-interventions-on-clostridium-difficile-infection-in-england-an-observational-study
#4
Kate E Dingle, Xavier Didelot, T Phuong Quan, David W Eyre, Nicole Stoesser, Tanya Golubchik, Rosalind M Harding, Daniel J Wilson, David Griffiths, Alison Vaughan, John M Finney, David H Wyllie, Sarah J Oakley, Warren N Fawley, Jane Freeman, Kirsti Morris, Jessica Martin, Philip Howard, Sherwood Gorbach, Ellie J C Goldstein, Diane M Citron, Susan Hopkins, Russell Hope, Alan P Johnson, Mark H Wilcox, Timothy E A Peto, A Sarah Walker, Derrick W Crook
BACKGROUND: The control of Clostridium difficile infections is an international clinical challenge. The incidence of C difficile in England declined by roughly 80% after 2006, following the implementation of national control policies; we tested two hypotheses to investigate their role in this decline. First, if C difficile infection declines in England were driven by reductions in use of particular antibiotics, then incidence of C difficile infections caused by resistant isolates should decline faster than that caused by susceptible isolates across multiple genotypes...
January 24, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28111981/-clean-out-of-the-map-knowing-and-doubting-space-at-india-s-high-imperial-frontiers
#5
Thomas Simpson
During the second half of the nineteenth century, land frontiers became areas of unique significance for surveyors in colonial India. These regions were understood to provide the most stringent tests for the men, instruments, and techniques that collectively constituted spatial data and representations. In many instances, however, the severity of the challenges that India's frontiers afforded stretched practices in the field and in the survey office beyond breaking point. Far from producing supposedly unequivocal maps, many involved in frontier surveying acknowledged that their work was problematic, partial, and prone to contrary readings...
January 1, 2017: History of Science; An Annual Review of Literature, Research and Teaching
https://www.readbyqxmd.com/read/28103999/-a-research-on-confucian-scholar-practicing-medicine-at-the-turn-of-the-jin-and-yuan-dynasties
#6
Y Q Li
After the rising of the Yuan Dynasty by defeating the Jin and Southern Song Dynasties, there were huge influences on the life of the Confucian scholars. A large number of Confucian scholar practiced medicine actively or passively. They practiced medicine in order to live safely in war time; or turned into the officials, with only a few of them even became senior officials. Some Confucian scholars changed their household registration by using the medical profession, and improved the identity and status in the society...
September 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28103984/-textual-research-on-han-chinese-formulae-collected-in-tubo-medical-manuscript-unearthed-in-bum-pa-che-tower
#7
Y H Liu, H C Nong
A Tibetan manuscript with title of Sman-dpyad gces-pa grub-pa kun-'dus-pa in the Collection of Practiced Medical Quintessence, was found in the basement of a Buddhist tower named 'Bum-pa-che in Lhokha (Shannan), Tibet. It contains a purgative recipe of TCM with its title "Powder of Han Region" and several ingredients in Chinese transliteration. Based upon the rule of medieval Chinese system of pronunciation with reference of related texts and studies, a textual research identifies it as a kind of Maren (seed of Cannabis sativa L...
November 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28103978/-cosmetological-thinking-and-methods-in-tcm-in-the-sui-tang-dynasty
#8
Y J Wu
In the heyday of Chinese feudal society, women's status in the society of the Sui-Tang period was improved in the Tang Dynasty.The demand for female to stay young and anti-aging had attracted lots of attention in the society, thus providing a favorable social environment for the formation and development of Chinese herbal cosmetology. The important representative medical works on traditional Chinese medicine (TCM) were published in the Sui and Tang Dynasties, such as Bei ji qian jin yao fang (Essential Recipes for Emergent Use Worth A Thousand Gold), Qian jin yi fang (Supplement to Recipes Worth A Thousand Gold), Wai tai mi yao (Arcane Essentials from the Imperial Library) etc...
November 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28095205/imperial-queerness-the-u-s-homophile-press-and-constructions-of-sexualities-in-asia-and-the-pacific-1953-1964
#9
Carly Simpson
This essay examines the ways in which U.S. homophile magazines represented and constructed Asia and the Pacific from 1953 to 1964. Through an analysis of 209 items that referenced Asia and the Pacific in ONE, Mattachine Review, and the Ladder, the essay argues that U.S. homophiles referenced the region in three primary ways: first, to create relationships, allies, and exchanges with people living in the region; second, to highlight the inferiority of the East and superiority of the West; and third, to reveal the cross-cultural and transhistorical nature of homosexuality...
January 17, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28062461/diverse-bacteria-affiliated-with-the-genera-microvirga-phyllobacterium-and-bradyrhizobium-nodulate-lupinus-micranthus-growing-in-soils-of-northern-tunisia
#10
Abdelhakim Msaddak, David Durán, Mokhtar Rejili, Mohamed Mars, Tomás Ruiz-Argüeso, Juan Imperial, José Palacios, Luis Rey
: The genetic diversity of bacterial populations nodulating Lupinus micranthus in five geographical sites from Northern Tunisia was examined. Phylogenetic analyses of fifty isolates based on recA and gyrB gene partial sequences grouped strains in seven clusters, five of which belong to genus Bradyrhizobium (28 isolates), one to Phyllobacterium (2 isolates), and one, remarkably, to Microvirga (20 isolates). The largest Bradyrhizobium cluster (17 isolates) grouped with the B. lupini species and the other five clusters were close to different, recently defined Bradyrhizobium species...
January 6, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28035124/your-epoch-is-not-for-trying-it-s-for-living-and-for-dying
#11
Leonid P Churilov
The article is devoted to biographies of three Russian physicians of the Silver Age (a period in the History of Russian culture between 1890 and 1917). They made early, significant and internationally recognized contribution into medical science and became eponymous, although social disasters of the twentieth century caused deep impact on their subsequent lives and careers, so their role was shadowed from global medical community. The article analyzes biographies and academic achievements of A-F.K. Siewert (aka: Zivert, Ziwert, von Siewert) (1872-1922), known for first description of the hereditary dyskinesia of cilia (as a triad of: situs inversus of the viscera, abnormal frontal sinuses producing sinusitis and bronchiectasis); S...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/28025915/field-station-as-stage-re-enacting-scientific-work-and-life-in-amani-tanzania
#12
P Wenzel Geissler, Ann H Kelly
Located high in Tanzania's Usambara Mountains, Amani Hill Station has been a site of progressive scientific endeavours for over a century, pushing the boundaries of botanical, zoological and medical knowledge, and providing expertise for imperial expansion, colonial welfare, national progress and international development efforts. The station's heyday was from the 1950s to the 1970s, a period of global disease eradication campaigns and the 'Africanization' of science. Today, Amani lies in a state of suspended motion...
December 2016: Social Studies of Science
https://www.readbyqxmd.com/read/28018315/addressing-the-antibiotic-resistance-problem-with-probiotics-reducing-the-risk-of-its-double-edged-sword-effect
#13
REVIEW
Ivan C V J Imperial, Joyce A Ibana
Antibiotic resistance is a global public health problem that requires our attention. Indiscriminate antibiotic use is a major contributor in the introduction of selective pressures in our natural environments that have significantly contributed in the rapid emergence of antibiotic-resistant microbial strains. The use of probiotics in lieu of antibiotic therapy to address certain health conditions in both animals and humans may alleviate these antibiotic-mediated selective pressures. Probiotic use is defined as the actual application of live beneficial microbes to obtain a desired outcome by preventing diseased state or improving general health...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28011775/metabosignal-a-network-based-approach-for-topological-analysis-of-metabotype-regulation-via-metabolic-and-signaling-pathways
#14
Andrea Rodriguez-Martinez, Rafael Ayala, Joram M Posma, Ana L Neves, Dominique Gauguier, Jeremy K Nicholson, Marc-Emmanuel Dumas
: MetaboSignal is an R package that allows merging metabolic and signaling pathways reported in the Kyoto Encyclopaedia of Genes and Genomes (KEGG). It is a network-based approach designed to navigate through topological relationships between genes (signaling- or metabolic-genes) and metabolites, representing a powerful tool to investigate the genetic landscape of metabolic phenotypes. AVAILABILITY AND IMPLEMENTATION: MetaboSignal is available from Bioconductor: https://bioconductor...
December 22, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27998339/juanita-de-barros%C3%A2-and-sean-stilwell%C3%A2-eds-public-health-and-the-imperial-project-trenton-nj-african-world-press-2016-pp-v-262-29-95-paperback-isbn-978-1592215331
#15
https://www.readbyqxmd.com/read/27993774/kodama-an-r-package-for-knowledge-discovery-and-data-mining
#16
Stefano Cacciatore, Leonardo Tenori, Claudio Luchinat, Phillip R Bennett, David A MacIntyre
: KODAMA, a novel learning algorithm for unsupervised feature extraction, is specifically designed for analysing noisy and high-dimensional datasets. Here we present an R package of the algorithm with additional functions that allow improved interpretation of high-dimensional data. The package requires no additional software and runs on all major platforms. AVAILABILITY AND IMPLEMENTATION: KODAMA is freely available from the R archive CRAN (http://cran.r-project...
December 19, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27974872/studies-on-exercise-physiology-and-performance-testing-of-racehorses-performed-in-japan-during-the-1930s-using-recovery-rate-as-an-index
#17
Atsushi Hiraga, Shigeru Sugano
The history of research on the exercise physiology of racehorses in Japan dates back to the 1930s. A research report entitled "Studies on exercise physiology and performance testing of the racehorse", published in 1933 by Shigeo Matsuba and Torao Shimamura of The University of Tokyo, was epoch-making and the most important study in the history of equine exercise physiology in Japan. Research results were reported from 92 Thoroughbred racehorses in a large-scale project during the period of 1928 to 1932 at the Shimofusa Imperial Farm and the Koiwai Farm, which were the two greatest racehorse farms at that time...
2016: Journal of Equine Science
https://www.readbyqxmd.com/read/27936427/an-observed-rise-in-%C3%AE-hydroxybutyrate-associated-deaths-in-london-evidence-to-suggest-a-possible-link-with-concomitant-rise-in-chemsex
#18
Joanna Hockenhull, Kevin G Murphy, Sue Paterson
BACKGROUND: Gamma-hydroxybutyrate (GHB) is the drug most linked to acute harm out of those used in chemsex, the incidence of which is reported to be increasing. However, there have been few systematic studies of the harms associated with GHB use. We investigated GHB-associated deaths from London coroners' jurisdictions between 2011 and 2015. METHODS: Blood and urine samples were collected by pathologists and submitted for toxicological analysis at the request of coroners...
January 2017: Forensic Science International
https://www.readbyqxmd.com/read/27927145/the-razor-s-edge-australian-rock-music-impairs-men-s-performance-when-pretending-to-be-a-surgeon
#19
Daisy Fancourt, Thomas Mw Burton, Aaron Williamon
OBJECTIVE: Over the past few decades there has been interest in the role of music in the operating theatre. However, despite many reported benefits, a number of potentially harmful effects of music have been identified. This study aimed to explore the effects of rock and classical music on surgical speed, accuracy and perceived distraction when performing multiorgan resection in the board game Operation. DESIGN: Single-blind, three-arm, randomised controlled trial...
December 12, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27925557/-don-t-be-afraid-of-failure
#20
(no author information available yet)
Venetia Wynter-Blyth has worked in oncology for 15 years. She spent 12 years as an upper gastrointestinal (GI) clinical nurse specialist before taking up her current post as Macmillan nurse consultant in upper GI cancers at Imperial College Healthcare NHS Trust in London. She was named RCN Nurse of the Year 2016 for creating PREPARE, a holistic 'prehabilitation' self-management programme for people with cancer who require surgery.
December 7, 2016: Nursing Standard
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