keyword
https://read.qxmd.com/read/38537125/efficacy-of-a-novel-antibiotic-drug-combination-toward-multidrug-resistant-ocular-pathogens
#1
JOURNAL ARTICLE
Lakshminarayanan Gowtham, Rachel A F Wozniak, Paul M Dunman, Esther Sheba, Prashant Garg, Joveeta Joseph
PURPOSE: Antimicrobial resistance is a global health threat, compounded by the reduction in the discovery of new antibiotics. A repurposed drugs-based approach could provide a viable alternative for the treatment of multidrug-resistant (MDR) bacterial infections. In this study, we sought to evaluate the in vitro efficacy of a novel drug combination, polymyxin B/trimethoprim (PT) + rifampin on MDR isolates from patients with bacterial keratitis in India. METHODS: Forty-three isolates, which included 20 Staphylococcus aureus, 19 Pseudomonas aeruginosa, 3 Pseudomonas stutzeri, and 1 Acinetobacter baumannii, were evaluated for their antibiotic resistance by minimum inhibitory concentration (MIC)...
March 26, 2024: Cornea
https://read.qxmd.com/read/38536968/manganese-nanoparticles-synthesis-mechanisms-of-influence-on-plant-resistance-to-stress-and-prospects-for-application-in-agricultural-chemistry
#2
REVIEW
Alla I Perfileva, Konstantin V Krutovsky
Manganese (Mn) is an important microelement for the mineral nutrition of plants, but it is not effectively absorbed from the soil and mineral salts added thereto and can also be toxic in high concentrations. Mn nanoparticles (NPs) are less toxic, more effective, and economical than Mn salts due to their nanosize. This article critically reviews the current publications on Mn NPs, focusing on their effects on plant health, growth, and stress tolerance, and explaining possible mechanisms of their effects. This review also provides basic information and examples of chemical, physical, and ecological ("green") methods for the synthesis of Mn NPs...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38536646/impact-of-immunosuppressed-status-on-prognosis-of-carbapenem-resistant-organisms-bloodstream-infections
#3
JOURNAL ARTICLE
Yuan-Yuan Li, Yan Chen, Shan Li, Yuan-Yuan Li, Ran An, Xiao-Yun Hu, Wei Jiang, Chun-Yao Wang, Run Dong, Qi-Wen Yang, Li Weng, Jin-Min Peng, Bin Du
INTRODUCTION: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients. METHODS: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients...
March 27, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38536635/the-acetic-acid-produced-by-lactobacillus-species-regulates-immune-function-to-alleviate-pedv-infection-in-piglets
#4
JOURNAL ARTICLE
Ming-Jie Sun, Jun Hong Xing, Qing-Song Yan, Bo-Shi Zou, Ying-Jie Wang, Tian-Ming Niu, Tong Yu, Hai-Bin Huang, Di Zhang, Shu-Min Zhang, Wu-Sheng Sun, Ruo-Nan Zou, Chun-Feng Wang, Chun-Wei Shi
Porcine epidemic diarrhea virus (PEDV) infection results in significant mortality among newborn piglets, leading to substantial economic setbacks in the pig industry. Short-chain fatty acids (SCFA), the metabolites of intestinal probiotics, play pivotal roles in modulating intestinal function, enhancing the intestinal barrier, and bolstering immune responses through diverse mechanisms. The protective potential of Lactobacillus delbrueckii, Lactobacillus johnsonii, and Lactococcus lactis was first noted when administered to PEDV-infected piglets...
March 27, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38536433/immobilised-antimicrobial-peptides-in-downregulation-of-biofilm
#5
REVIEW
Moupriya Nag, Debasmita Bhattacharya, Sayantani Garai, Bandita Dutta, Sreejita Ghosh, Rina Rani Ray, Dibyajit Lahiri
Colonisation of sessile bacterial species on biotic and abiotic surfaces is responsible for the development of various infections in humans. At present, biofilm-associated chronic infections have been a prime concern among the healthcare practitioners since they are impermeable to drugs, resulting in the development of antibiotic resistance or multi-drug resistance. For a few decades, a lot of research activity has been performed in the development of alternative therapeutics to combat biofilm-associated chronic infections...
March 27, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38536216/virulence-genes-resistome-and-mobilome-of-streptococcus-suis-strains-isolated-in-france
#6
JOURNAL ARTICLE
Manon Dechêne-Tempier, Claire de Boisséson, Pierrick Lucas, Stéphanie Bougeard, Virginie Libante, Corinne Marois-Créhan, Sophie Payot
Streptococcus suis is a leading cause of infection in pigs, causing extensive economic losses. In addition, it can also infect wild fauna, and can be responsible for severe infections in humans. Increasing antimicrobial resistance (AMR) has been described in S. suis worldwide and most of the AMR genes are carried by mobile genetic elements (MGEs). This contributes to their dissemination by horizontal gene transfer. A collection of 102 strains isolated from humans, pigs and wild boars in France was subjected to whole genome sequencing in order to: (i) study their genetic diversity, (ii) evaluate their content in virulence-associated genes, (iii) decipher the mechanisms responsible for their AMR and their association with MGEs, and (iv) study their ability to acquire extracellular DNA by natural transformation...
March 2024: Microbial Genomics
https://read.qxmd.com/read/38536111/efflux-pump-inhibitor-potentiates-the-antimicrobial-photodynamic-inactivation-of-multidrug-resistant-acinetobacter-baumannii
#7
JOURNAL ARTICLE
Zahra Shirdel, Zahra Fekrirad
Background: Acinetobacter baumannii , a nosocomial pathogen, poses a major public health problem due to generating resistance to several antimicrobial agents. Antimicrobial photodynamic inactivation (APDI) employs a nontoxic dye as a photosensitizer (PS) and light to produce reactive oxygen species that destroy bacterial cells. The intracellular concentration of PS could be affected by factors such as the function of efflux pumps to emit PS from the cytosol. Objective: To evaluate the augmentation effect of an efflux pump inhibitor, verapamil, three multidrug-resistant A...
March 27, 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38536098/-escherichia-coli-isolated-from-bovine-sources-encoding-the-fosfomycin-resistance-gene-fosa7-5
#8
JOURNAL ARTICLE
Bradd J Haley, Seon Woo Kim, Jo Ann Van Kessel
Dairy animals are reservoirs of antimicrobial-resistant Escherichia coli that are frequently resistant to tetracycline, aminoglycoside, β-lactam, sulfonamide, and macrolide-lincosamide-streptogramin B antibiotics. However, resistance to other classes of antimicrobials is less frequently observed, and resistance to fosfomycin is rarely observed in E. coli . In this study, we describe the genomic characteristics of E. coli encoding fosA7.5 that have been recovered from bovine sources in the United States...
March 27, 2024: Foodborne Pathogens and Disease
https://read.qxmd.com/read/38535973/-pseudomonas-stutzeri-bloodstream-infection-is-a-prevailing-community-onset-disease-with-important-mortality-rates-results-from-a-retrospective-observational-study-in-australia
#9
JOURNAL ARTICLE
Juan P Horcajada, Felicity Edwards, Silvia Fonio, Milagro Montero, Patrick Harris, David L Paterson, Kevin B Laupland
BACKGROUND: The recognition of Pseudomonas stutzer i as a cause of infections in humans has been increasing. However, only case reports and small series of P. stutzeri bloodstream infections have been published. Epidemiological data on these infections are extremely scarce. Our objective was to describe the incidence, epidemiology, antimicrobial resistance rates, and outcomes of P. stutzeri bloodstream infections in a large population-based cohort in Australia. METHODS: Retrospective, laboratory-based surveillance study conducted in Queensland, Australia (population ≈ 5 million) during 2000-2019...
March 27, 2024: Infectious Diseases
https://read.qxmd.com/read/38535854/design-and-validation-of-rt-pcr-assays-to-differentiate-salmonella-vaccine-strains-from-wild-type-field-isolates
#10
JOURNAL ARTICLE
Pieter-Jan Ceyssens, Doris Mueller-Doblies, Wesley Mattheus
The timely differentiation of the AviPro Salmonella VAC T and VAC E strains from the wild-type Salmonella enterica ser. Typhimurium and ser. Enteritidis isolates is crucial for effectively monitoring veterinary isolates. Currently, the distinction between field and vaccine strains has been conducted routinely via phenotypic antimicrobial resistance testing since the vaccines were first introduced more than 20 years ago, and the differentiation based on the antimicrobial resistance profile is still a valid and well-established method...
March 6, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535822/cationicity-enhancement-on-the-hydrophilic-face-of-ctriporin-significantly-reduces-its-hemolytic-activity-and-improves-the-antimicrobial-activity-against-antibiotic-resistant-eskape-pathogens
#11
JOURNAL ARTICLE
Xudong Luo, Huan Deng, Li Ding, Xiangdong Ye, Fang Sun, Chenhu Qin, Zongyun Chen
The ESKAPE pathogen-associated antimicrobial resistance is a global public health issue, and novel therapeutic strategies are urgently needed. The short cationic antimicrobial peptide (AMP) family represents an important subfamily of scorpion-derived AMPs, but high hemolysis and poor antimicrobial activity hinder their therapeutic application. Here, we recomposed the hydrophilic face of Ctriporin through lysine substitution. We observed non-linear correlations between the physiochemical properties of the peptides and their activities, and significant deviations regarding the changes of antimicrobial activities against different bacterial species, as well as hemolytic activity...
March 18, 2024: Toxins
https://read.qxmd.com/read/38535816/diversity-and-molecular-evolution-of-antimicrobial-peptides-in-caecilian-amphibians
#12
JOURNAL ARTICLE
Mario Benítez-Prián, Héctor Lorente-Martínez, Ainhoa Agorreta, David J Gower, Mark Wilkinson, Kim Roelants, Diego San Mauro
Antimicrobial peptides (AMPs) are key molecules in the innate immune defence of vertebrates with rapid action, broad antimicrobial spectrum, and ability to evade pathogen resistance mechanisms. To date, amphibians are the major group of vertebrates from which most AMPs have been characterised, but most studies have focused on the bioactive skin secretions of anurans (frogs and toads). In this study, we have analysed the complete genomes and/or transcriptomes of eight species of caecilian amphibians (order Gymnophiona) and characterised the diversity, molecular evolution, and antimicrobial potential of the AMP repertoire of this order of amphibians...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535612/fungemia-by-wickerhamomyces-anomalus-a-narrative-review
#13
REVIEW
Petros Ioannou, Stella Baliou, Diamantis P Kofteridis
Wickerhamomyces anomalus has been previously classified as Hansenula anomala , Pichia anomala , and Candida pelliculosa and was recently reclassified in the genus Wickerhamomyces after phylogenetic analysis of its genetic sequence. An increasing number of reports of human infections by W. anomalus have emerged, suggesting that this microorganism is an emerging pathogen. The present review aimed to provide data on the epidemiology, antifungal resistance, clinical characteristics, treatment, and outcomes of fungemia by W...
March 21, 2024: Pathogens
https://read.qxmd.com/read/38535603/obtaining-microbiologically-safe-hatching-eggs-from-hatcheries-using-essential-oils-for-integrated-sanitization-strategies-in-hatching-eggs-poultry-houses-and-poultry
#14
REVIEW
Gabriel da Silva Oliveira, Concepta McManus, Igor Rafael Ribeiro Vale, Vinícius Machado Dos Santos
Essential oils are liquids containing non-toxic compounds that are unfavorable to the growth of microorganisms. They are sold globally at affordable or very high prices, depending on the availability and type of plant, the scale of production, the extraction method, costs associated with logistics and electricity consumption, among other variables. Each year, the quantity of research dedicated to the antimicrobial potential of essential oils in poultry farming is expanding. Researchers consensually relay that this increase is due to the growing resistance of microorganisms to traditional antimicrobials and concerns about the toxicity of these products...
March 18, 2024: Pathogens
https://read.qxmd.com/read/38535572/genetic-diversification-and-resistome-of-coagulase-negative-staphylococci-from-nostrils-of-healthy-dogs-and-dog-owners-in-la-rioja-spain
#15
JOURNAL ARTICLE
Idris Nasir Abdullahi, Carmen Lozano, Carmen González-Azcona, Myriam Zarazaga, Carmen Torres
Coagulase-negative staphylococci (CoNS) species in healthy dogs and their owners could be transferred between these hosts and carry diverse antimicrobial resistance (AMR) genes of public health concern. This study determined the frequency, diversity, and AMR genes of nasal CoNS from healthy dogs and in-contact people as well as the rate of intra-household (between healthy dogs and dog-owners) transmission of CoNS. Nasal samples were collected and processed from 34 dogs and 41 humans from 27 households, and CoNS identification was done by MALDI-TOF-MS...
March 5, 2024: Pathogens
https://read.qxmd.com/read/38535544/pathogens-causing-pediatric-community-acquired-urinary-tract-infections-and-their-increasing-antimicrobial-resistance-a-nationwide-study
#16
JOURNAL ARTICLE
Vered Shkalim Zemer, Shai Ashkenazi, Yoel Levinsky, Yael Richenberg, Eyal Jacobson, Shay Nathanson, Tzippy Shochat, Shiri Kushnir, Moriya Cohen, Avner Herman Cohen
Urinary tract infections (UTIs) in childhood are common and are associated with considerable acute morbidity and long-term complications. The need for updated data to optimize empiric antibiotic therapy is crucial. We aimed to investigate the pathogens causing pediatric community acquired UTIs, their correlation with demographic characteristics, and trends in their antimicrobial resistance. This nationwide cross-sectional study included all 53,203 children (<18 years) diagnosed with UTI in community outpatient clinics in the following selected years: 2007, 2011, 2015, 2019 and 2021...
February 24, 2024: Pathogens
https://read.qxmd.com/read/38535540/types-and-mechanisms-of-efflux-pump-systems-and-the-potential-of-efflux-pump-inhibitors-in-the-restoration-of-antimicrobial-susceptibility-with-a-special-reference-to-acinetobacter-baumannii
#17
REVIEW
Kira M Zack, Trent Sorenson, Suresh G Joshi
Bacteria express a plethora of efflux pumps that can transport structurally varied molecules, including antimicrobial agents and antibiotics, out of cells. Thus, efflux pump systems participate in lowering intracellular concentrations of antibiotics, which allows phenotypic multidrug-resistant (MDR) bacteria to survive effectively amid higher concentrations of antibiotics. Acinetobacter baumannii is one of the classic examples of pathogens that can carry multiple efflux pump systems, which allows these bacteria to be MDR-to-pan-drug resistant and is now considered a public health threat...
February 23, 2024: Pathogens
https://read.qxmd.com/read/38535533/new-frontier-on-antimicrobial-therapy-long-acting-lipoglycopeptides
#18
REVIEW
Valentina Siciliano, Flavio Sangiorgi, Pierluigi Del Vecchio, Layla Vahedi, Maya Manuela Gross, Angela Saviano, Veronica Ojetti
Long-acting lipoglycopeptides (LGPs), such as dalbavancin and oritavancin, are semisynthetic antibiotics known for their strong effectiveness against a wide array of Gram-positive bacteria. This includes Staphylococcus aureus , both methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) strains, coagulase-negative Staphylococci (CoNS), streptococci, and vancomycin-sensitive Enterococcus faecalis . A literature search was conducted on PubMed and on ClinicalTrials.gov to identify articles published until July 2023 investigating the use of oritavancin and dalbavancin in clinical practice...
February 20, 2024: Pathogens
https://read.qxmd.com/read/38535474/novel-1-3-4-thiadiazole-3-2-a-pyrimidin-5-ones-as-promising-biofilm-dispersal-agents-against-relevant-gram-positive-and-gram-negative-pathogens
#19
JOURNAL ARTICLE
Daniela Carbone, Camilla Pecoraro, Fabio Scianò, Valentina Catania, Domenico Schillaci, Barbara Manachini, Stella Cascioferro, Patrizia Diana, Barbara Parrino
Biofilm-associated infections pose significant challenges in healthcare settings due to their resistance to conventional antimicrobial therapies. In the last decade, the marine environment has been a precious source of bioactive molecules, including numerous derivatives with antibiofilm activity. In this study, we reported the synthesis and the biological evaluation of a new series of twenty-two thiadiazopyrimidinone derivatives obtained by using a hybridization approach combining relevant chemical features of two important classes of marine compounds: nortopsentin analogues and Essramycin derivatives...
March 15, 2024: Marine Drugs
https://read.qxmd.com/read/38535266/antibacterial-and-antibiofouling-activities-of-carbon-polymerized-dots-polyurethane-and-c-60-polyurethane-composite-films
#20
JOURNAL ARTICLE
Zoran M Marković, Milica D Budimir Filimonović, Dušan D Milivojević, Janez Kovač, Biljana M Todorović Marković
The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60 ...
March 17, 2024: Journal of Functional Biomaterials
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