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https://www.readbyqxmd.com/read/29102619/incidence-and-treatment-of-patients-diagnosed-with-inflammatory-bowel-diseases-at-60-years-or-older-in-sweden
#1
Åsa H Everhov, Jonas Halfvarson, Pär Myrelid, Michael C Sachs, Caroline Nordenvall, Jonas Söderling, Anders Ekbom, Martin Neovius, Jonas F Ludvigsson, Johan Askling, Ola Olén
BACKGROUND & AIMS: Diagnosis of inflammatory bowel diseases (IBD) is increasing among elderly persons (60 years or older). We performed a nationwide population-based study to estimate incidence and treatment. METHODS: We identified all incident IBD cases in Sweden, from 2006 through 2013, using national registers, and up to 10 matched population comparator subjects. We collected data on the patients' health care contacts and estimated incidence rates, health service burden, pharmacologic treatments, extra-intestinal manifestations, and surgeries in relation to age of IBD onset (pediatric, less than 18 years; adults, 18-59 years; elderly, 60 years or older)...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29064110/colectomy-prior-to-diagnosis-of-primary-sclerosing-cholangitis-is-associated-with-improved-prognosis-in-a-nationwide-cohort-study-of-2594-psc-ibd-patients
#2
C Nordenvall, O Olén, P J Nilsson, E von Seth, A Ekbom, M Bottai, P Myrelid, A Bergquist
BACKGROUND: Despite the close relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), the association between colectomy and the prognosis of PSC remains controversial. AIM: To explore whether colectomy prior to PSC-diagnosis is associated with transplant-free survival. METHODS: A nationwide cohort study in Sweden including all patients aged 18 to 69 years in whom both PSC and IBD was diagnosed between 1987 and 2014 was undertaken...
October 24, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29029152/surgical-treatment-in-childhood-onset-inflammatory-bowel-disease-a-nationwide-register-based-study-of-4-695-incident-patients-in-sweden-2002-2014
#3
Caroline Nordenvall, Oda Rosvall, Matteo Bottai, Åsa H Everhov, Petter Malmborg, Karin E Smedby, Anders Ekbom, Johan Askling, Jonas F Ludvigsson, Pär Myrelid, Ola Olén
Background and Aims: The incidence of childhood-onset (<18 years) inflammatory bowel disease is increasing worldwide, and some studies suggest that it represents a more severe disease phenotype. Few nationwide, population-based studies have evaluated the surgical burden in patients with childhood-onset IBD, and whether the improved medical treatment has influenced the need for gastrointestinal surgery. The aim was to examine whether the surgical treatment at any age of patients with childhood-onset IBD has changed over time...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28953766/delusional-parasitosis-treated-by-atypical-antipsychotic-and-selective-serotonin-reuptake-inhibitor-a-case-report
#4
Tiffany Roulet, Nicolas Zdanowicz
BACKGROUND: Delusional parasitosis (DP) is an uncommon psychiatric disorder. Patients suffering from this disorder have the fixed false belief of being infested by a parasite. Because of this condition, patients mainly consult with dermatologists or general practitioners. They are often reluctant to see a psychiatrist and to take treatment with antipsychotics because of their belief. The following describes the case of a woman who has the particularity that the DP started a few days after sertraline interruption...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28942236/increased-incidence-of-bowel-cancer-after-non-surgical-treatment-of-appendicitis
#5
Malin Enblad, Helgi Birgisson, Anders Ekbom, Fredrik Sandin, Wilhelm Graf
BACKGROUND: There is an ongoing debate on the use of antibiotics instead of appendectomy for treating appendicitis but diagnostic difficulties and longstanding inflammation might lead to increased incidence of bowel cancer in these patients. The aim of this population-based study was to investigate the incidence of bowel cancer after non-surgical treatment of appendicitis. PATIENTS AND METHODS: Patients diagnosed with appendicitis but lacking the surgical procedure code for appendix removal were retrieved from the Swedish National Inpatient Register 1987-2013...
September 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28931512/childhood-onset-inflammatory-bowel-disease-and-risk-of-cancer-a-swedish-nationwide-cohort-study-1964-2014
#6
O Olén, J Askling, M C Sachs, P Frumento, M Neovius, K E Smedby, A Ekbom, P Malmborg, J F Ludvigsson
Objective To assess risk of cancer in patients with childhood onset inflammatory bowel disease in childhood and adulthood.Design Cohort study with matched general population reference individuals using multivariable Cox regression to estimate hazard ratios.Setting Swedish national patient register (both inpatient and non-primary outpatient care) 1964-2014.Participants Incident cases of childhood onset (<18 years) inflammatory bowel disease (n=9405: ulcerative colitis, n=4648; Crohn's disease, n=3768; unclassified, n=989) compared with 92 870 comparators from the general population matched for sex, age, birth year, and county...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28895165/preliminary-results-of-tissue-engineered-injection-laryngoplasty-material-in-a-rabbit-model
#7
Michael S Oldenburg, Dale C Ekbom, Serban San Marina, Steve Voss, Tiffany Chen, Joaquin Garcia, Jeffery R Janus
OBJECTIVES/HYPOTHESIS: Design and test a novel biomaterial for injection laryngoplasty aimed to increase the duration of effectiveness of micronized acellular dermis. STUDY DESIGN: Animal model. METHODS: Injection laryngoplasty was performed in three groups (n = 5) of New Zealand White rabbits. Acellular dermis was either used alone as a control (group 1), was combined with undifferentiated stem cells (group 2), or with predifferentiated chondrocytic cells (group 3)...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28869939/survival-of-dialysis-patients-with-restless-legs-syndrome-a-15-year-follow-up-study
#8
Simone Baiardi, Susanna Mondini, Alessandro Baldi Antognini, Antonio Santoro, Fabio Cirignotta
BACKGROUND: Restless legs syndrome, also known as Willis/Ekbom disease (RLS/WED), is a sleep-related, sensorimotor disorder with a high prevalence among end-stage renal disease (ESRD) patients undergoing haemodialysis (HD) (about 15-40%). Whether RLS/WED in uremic patients influences cardiovascular morbidity and mortality remains a matter of controversy. The aim of this study was to evaluate the relationship of RLS/WED and mortality in a population of chronically dialyzed patients. METHOD: In 1996, we studied 128 patients with ESRD undergoing HD; 47 subjects (36...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28832673/consumption-and-direct-costs-of-dental-care-for-patients-with-head-and-neck-cancer-a-16-year-cohort-study
#9
Duangjai Lexomboon, Pär Karlsson, Jan Adolfsson, Anders Ekbom, Aron Naimi-Akbar, Shahram Bahmanyar, Scott Montgomery, Gunilla Sandborgh-Englund
Patients with head and neck (H&N) cancer are commonly treated with surgery and/or radiotherapy, which can increase the risk of oral infection, dental caries, and periodontal disease. The present study investigated dental care consumption and costs in patient with H&N cancer before and after the cancer diagnosis. Data from Swedish regional and national registers were used to follow up dental care utilization and dental procedure costs. The analysis included 2,754 patients who had been diagnosed with H&N cancer (exposed cohort) in Stockholm County, Sweden, during 2000-2012 and 13,036 matched persons without cancer (unexposed cohort)...
2017: PloS One
https://www.readbyqxmd.com/read/28818004/identification-and-treatment-of-augmentation-in-patients-with-restless-legs-syndrome-practical-recommendations
#10
REVIEW
James Geyer, Richard Bogan
Restless legs syndrome (RLS) is a chronic disorder causing clinically significant discomfort to approximately 3% of adults. Although RLS was first identified centuries ago, our understanding of this disorder, its causes, and its treatments is still evolving. In particular, our knowledge of the potential negative effects of RLS treatments, including dopaminergic augmentation, continues to expand. Augmentation, which refers to a paradoxical treatment-related increase in RLS symptoms, has been associated with all three dopamine agonists approved for the treatment of RLS - rotigotine, pramipexole, and ropinirole...
September 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28777169/whatcha-talkin-bout-willis-ekbom
#11
Steven L Lewis
No abstract text is available yet for this article.
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28752637/anti-tnf-treatment-in-crohn-s-disease-and-risk-of-bowel-resection-a-population-based-cohort-study
#12
M Eberhardson, J K Söderling, M Neovius, T Cars, P Myrelid, J F Ludvigsson, J Askling, A Ekbom, O Olén
BACKGROUND: TNF inhibitors (TNFi) have been shown to reduce the need for surgery in Crohn's disease, but few studies have examined their effect beyond the first year of treatment. AIM: To conduct a register-based observational cohort study in Sweden 2006-2014 to investigate the risk of bowel resection in bowel surgery naïve TNFi-treated Crohn's disease patients and whether patients on TNFi ≥12 months are less likely to undergo bowel resection than patients discontinuing treatment before 12 months...
September 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28693958/childhood-obesity-obesity-treatment-outcome-and-achieved-education-a-prospective-cohort-study
#13
Emilia Hagman, Pernilla Danielsson, Lena Brandt, Viktoria Svensson, Anders Ekbom, Claude Marcus
PURPOSE: Childhood obesity represents a social burden. This study aims to investigate whether achieved educational level differs in young adults who have suffered obesity in childhood compared with the general population and to determine how obesity treatment influences achieved educational level. METHODS: This prospective cohort study includes subjects from the Swedish Childhood Obesity Treatment Registry (BORIS, n = 1,465) who were followed up after 20 years of age...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28691216/statins-and-ace-inhibitors-are-associated-with-reduced-mortality-and-morbidity-in-chronic-liver-disease
#14
Knut Stokkeland, Christine Takami Lageborn, Anders Ekbom, Jonas Höijer, Matteo Bottai, Per Stål, Karin Söderberg-Löfdal
Liver fibrosis is a common response to many chronic liver diseases. The aim of our study was to explore whether pharmacotherapy for concurrent diseases affects overall mortality, liver-related mortality and liver-related morbidity in patients with chronic liver disease. We performed a register-based cohort study of all patients with a first-time diagnosis of chronic liver disease between 2005 and 2012 in Sweden (n=70 546). Data from the Patient Register, the Prescribed Drug Register and the Death Certificate Register were linked...
July 10, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28682991/the-effect-of-cold-dialysis-in-motor-and-sensory-symptoms-of-rls-wed-occurring-during-hemodialysis-a-double-blind-study
#15
Giorgos K Sakkas, Evaggelia Tsaknaki, Clara S Rosa, Christoforos D Giannaki, Argyro A Krase, Eleftherios Lavdas, Georgios M Hadjigeorgiou, Ioannis Stefanidis, Christina Karatzaferi
Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a common sensorimotory disorder affecting almost 30% of hemodialysis (HD) patients. RLS/WED induces discomfort during rest hours, and its symptoms have also been observed during HD sessions. Anecdotal reports suggest that cooling the dialysate solution during dialysis could help patients overcome those symptoms and improve restlessness. The aim of this double-blind study was to assess whether a reduction of the dialysate temperature by 1°C could reduce motor and sensory symptoms of RLS/WED occurring during HD...
July 4, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28619185/high-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-rls-wed-among-people-living-at-high-altitude-in-the-indian-himalaya
#16
Ravi Gupta, Jan Ulfberg, Richard P Allen, Deepak Goel
BACKGROUND: At high altitude, prevalence of restless legs syndrome has been found to be greater than expected in small population-based studies, which did not use validated tools for identification of RLS. However, it is not known as to whether this increased prevalence is associated with altitude or increased risk factors for RLS in these populations or errors in identification of RLS. METHOD: This population based, door-to-door study was conducted at low altitude (400 m above sea level) and high altitudes (1900-2000 m and 3200 m above sea level) using random stratified sampling in Himalayan and sub-Himalayan region of India...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28615912/carbamazepine-a-symptomatic-treatment-of-the-paresthesiae-associated-with-lhermitte-s-sign
#17
Karl Ekbom
No abstract text is available yet for this article.
April 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28615772/postherpetic-neuralgia-presenting-as-delusional-parasitosis-a-case-series
#18
Shailendra Mohan Tripathi, Priti Singh, Nisha Mani Pandey
Delusional parasitosis (DP) or Ekbom's disease is a rare psychiatric condition where the sufferers have a firm-fixed belief of insects crawling over their skin. The condition may be primary monosymptomatic hypochrondrical delusion or secondary to an underlying psychiatric or organic condition. We present two cases of elderly men presenting with classical symptomatology of DP, which is found to be secondary to postherpetic neuralgia following an acute episode of shingles or herpes zoster infection. One patient responded to a combination of antipsychotic, olanzapine, and pregabalin, used for neuropathic pain, and the other patient responded completely with medications used for neuropathic pain only without any antipsychotic use...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28614818/thyroid-stimulating-hormone-degree-of-obesity-and-metabolic-risk-markers-in-a-cohort-of-swedish-children-with-obesity
#19
Veroniqa Lundbäck, Kerstin Ekbom, Emilia Hagman, Ingrid Dahlman, Claude Marcus
BACKGROUND/AIMS: Thyroid-stimulating hormone (TSH) is affected in obesity and might influence metabolic risk. It is unclear what mechanisms cause elevated TSH in obesity. We aimed to investigate TSH status within the normal range and the association of TSH with degree of obesity and metabolic parameters in children with obesity. METHODS: A total of 3,459 children, aged 3.0-17.9 years, were identified in the Swedish Childhood Obesity Treatment Registry, BORIS. Age, gender, TSH, free triiodothyronine (fT3), free thyroxine (fT4), body mass index standard deviation scores (BMI SDS), as well as variables of lipid and glucose metabolism were examined...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28562115/a-register-based-study-adverse-events-in-colonoscopies-performed-in-sweden-2001-2013
#20
Anna Forsberg, Ulf Hammar, Anders Ekbom, Rolf Hultcrantz
OBJECTIVES: The rates for colonoscopy-associated adverse events vary considerably worldwide. In Sweden, the figures are known to a limited extent. We assessed the frequency of severe colonoscopy-related adverse events and the impacts of different risk factors, including the use of general anaesthesia. MATERIAL AND METHODS: This is a retrospective population-based cohort study of the colonoscopies performed during the years 2001-2013 on adults identified in the Swedish health registers...
September 2017: Scandinavian Journal of Gastroenterology
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