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https://www.readbyqxmd.com/read/28429227/secretion-of-thioredoxin-peroxidase-protein-of-cat-liver-fluke-opisthorchis-felineus-during-modeling-of-experimental-opisthorchiasis
#1
V A Petrenko, M Yu Pakharukova, A V Kovner, M N L'vova, V V Lyakhovich, V A Mordvinov
Mechanisms of thioredoxin peroxidase secretion by Opisthorchis felineus were studied in vivo and in vitro. Specific antibodies were obtained and used for western blotting and immunohistochemical detection in Syrian hamster model of opisthorchiasis. Secreted thioredoxin peroxidase protein was accumulated in the worm incubation medium under conditions of oxidative stress and in bile duct cells of hamsters with chronic opisthorchiasis.
April 21, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28426425/the-role-of-domestic-dogs-in-the-transmission-of-zoonotic-helminthes-in-a-rural-area-of-mekong-river-basin
#2
Marcello Otake Sato, Megumi Sato, Tippayarat Yoonuan, Tiengkham Pongvongsa, Surapol Sanguankiat, Sengchanh Kounnavong, Wanna Maipanich, Yuichi Chigusa, Kazuhiko Moji, Jitra Waikagul
Dogs have been bred since ancient times for companionship, hunting, protection, shepherding and other human activities. Some canine helminth parasites can cause significant clinical diseases in humans as Opisthorchis viverrini causing cholangiocarcinoma in Southeast Asian Countries. In this study, socio-cultural questionnaire, canine parasitological analysis, necropsy, parasite molecular confirmation and dog roaming data were evaluated in Savannakhet, Lao-PDR, a typical Mekong Basin area. Dog owners comprised 48...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28426420/disruption-of-egg-production-by-triclabendazole-resistant-fasciola-hepatica-following-treatment-with-a-commercial-preparation-of-myrrh-mirazid
#3
Mohamed M O Abdelaal, Gerard P Brennan, Robert E B Hanna, Ahmed Abdel-Aziz, Ian Fairweather
An in vitro study has been carried out to monitor changes to the female reproductive system in adult triclabendazole (TCBZ)-resistant Fasciola hepatica following treatment with a commercial preparation of myrrh ("Mirazid"). Flukes were immersed for 6 h and 24 h in myrrh extract at a concentration of 200 µg/ml, then processed for histological and transmission electron microscope (TEM) examination of the uterus, Mehlis' gland, ovary and vitellaria. Egg production had become abnormal at 6 h post-treatment (pt), with the uterine lumen being filled with free vitelline cells and masses of shell protein material; few eggs were present...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28425707/development-of-a-potent-wound-healing-agent-based-on-the-liver-fluke-granulin-structural-fold
#4
Paramjit S Bansal, Michael J Smout, David Wilson, Claudia Cobos Caceres, Mohadeseh Dastpeyman, Javier Sotillo, Julia Seifert, Paul J Brindley, Alex Loukas, Norelle L Daly
Granulins are a family of protein growth factors that are involved in cell proliferation. An orthologue of granulin from the human parasitic liver fluke Opisthorchis viverrini, known as Ov-GRN-1, induces angiogenesis and accelerates wound repair. Recombinant Ov-GRN-1 production is complex, and poses an obstacle for clinical development. To identify the bioactive region(s) of Ov-GRN-1, four truncated N-terminal analogues were synthesized and characterized structurally using NMR spectroscopy. Peptides that contained only two native disulfide bonds lack the characteristic granulin -hairpin structure...
April 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28425423/pathology-and-molecular-analysis-of-hapalotrema-mistroides-digenea-spirorchiidae-infecting-a-mediterranean-loggerhead-turtle-caretta-caretta
#5
M Santoro, F Di Nocera, D Iaccarino, S P Lawton, A Cerrone, B Degli Uberti, M D'Amore, A Affuso, S Hochscheid, F Maffucci, G Galiero
Turtle blood flukes belonging to the family Spirorchiidae (Digenea) represent a major threat for sea turtle health and are considered the most important parasitic cause of turtle stranding and mortality worldwide. Despite the large diversity of spirorchiid species found globally, there are only 2 records for free-ranging Mediterranean sea turtles that date back to the late 1800s involving just Hapalotrema mistroides Monticelli, 1896. This study describes the first fatal confirmed case of spirorchiidiasis in a free-ranging Mediterranean loggerhead turtle Caretta caretta (Linnaeus) and, owing to the complexities of taxonomic identification of these parasites, provides the first molecular characterization and phylogenetic analysis of H...
April 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28424102/gaining-insights-into-the-ecological-role-of-the-new-zealand-sole-peltorhamphus-novaezeelandiae-through-parasites
#6
T Anglade, H S Randhawa
Despite the fact that tapeworms comprise the bulk of parasite communities of sharks in marine ecosystems, little is known about their life cycles and, more specifically, about the potential intermediate hosts they utilize as transmission routes. In the absence of morphological features required for specific identification of larval tapeworms from potential intermediate hosts, recent molecular advances have contributed to linking larval and adult parasites and, in some instances, uncovering unknown trophic links...
April 20, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28421805/trematode-aspidogastrea-found-in-the-freshwater-mussels-in-the-yangtze-river-basin
#7
Xiaodong Zhan, Chaopin Li, Hua Wu
OBJECTIVE: To investigate the prevalence of trematode Aspidogastrea in the freshwater mussels in the Yangtze River basin within Anhui province, China. METHODS: We initially harvested the freshwater mussels living in the Yangtze River running through Anhui area, and labeled them with corresponding number. Then the samples were dissected for isolating the flukes, which were identified by conventional staining. RESULTS: Infection rate of trematode Aspidogastrea in freshwater mussels in the Yangtze River basin within the territory of Anhui province was 30...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28420302/the-genus-spirorchis-maccallum-1918-digenea-schistosomatoidea-and-the-early-history-of-parasitology-in-the-united-states
#8
Thomas Reid Platt
We know little about the founders of our discipline apart from their scientific contributions and brief biographical sketches, most frequently in published obituaries. A number of years ago, Ralph Lichtenfels, then Director of the National Parasite Collection, sent me photocopies of letters between Henry Baldwin Ward, Horace W. Stunkard, George A. MacCallum, and William G. MacCallum dating from the early years of the 20th century that hinted at a series of conflicts centered on the proposal of Spirorchis MacCallum, 1918 (Digenea: Schistosomatoidea)...
April 18, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28415922/host-pharmacokinetics-and-drug-accumulation-of-anthelmintics-within-target-helminth-parasites-of-ruminants
#9
A Lifschitz, C Lanusse, L Alvarez
Anthelmintic drugs require effective concentrations to be attained at the site of parasite location for a certain period to assure their efficacy. The processes of absorption, distribution, metabolism and excretion (pharmacokinetic phase) directly influence drug concentrations attained at the site of action and the resultant pharmacological effect. The aim of the current review article was to provide an overview of the relationship between the pharmacokinetic features of different anthelmintic drugs, their availability in host tissues, accumulation within target helminths and resulting therapeutic efficacy...
April 17, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28410676/the-immunoregulatory-effects-of-co-infection-with-fasciola-hepatica-from-bovine-tuberculosis-to-johne-s-disease
#10
REVIEW
Amalia Naranjo Lucena, Laura Garza Cuartero, Grace Mulcahy, Annetta Zintl
Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically-important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28407789/identification-and-functional-characterisation-of-a-schistosoma-japonicum-insulin-like-peptide
#11
Xiaofeng Du, Donald P McManus, Pengfei Cai, Wei Hu, Hong You
BACKGROUND: Previous studies have shown that insulin receptors in schistosomes, triggered by host insulin, play an important role in parasite growth, development and fecundity by regulating glucose metabolism. However, limited information is available on the recently identified endogenous insulin-like peptide (ILP) in blood flukes. RESULTS: We isolated ILPs from Schistosoma japonicum (SjILP) and S. recognised (SmILP) and present results of their molecular and structural analysis...
April 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28399142/oral-cavity-hydrodynamics-and-drag-production-in-balaenid-whale-suspension-feeding
#12
Jean Potvin, Alexander J Werth
Balaenid whales feed on large aggregates of small and slow-moving prey (predominantly copepods) through a filtration process enabled by baleen. These whales exhibit continuous filtration, namely, with the mouth kept partially opened and the baleen exposed to oncoming prey-laden waters while fluking. The process is an example of crossflow filtration (CFF) in which most of the particulates (prey) are separated from the substrate (water) without ever coming into contact with the filtering surface (baleen). This paper discusses the simulation of baleen filtration hydrodynamics based on a type of hydraulic circuit modeling commonly used in microfluidics, but adapted to the much higher Reynolds number flows typical of whale hydrodynamics...
2017: PloS One
https://www.readbyqxmd.com/read/28396295/molecular-characterization-of-fasciola-flukes-obtained-from-wild-sika-deer-and-domestic-cattle-in-hokkaido-japan
#13
Madoka Ichikawa-Seki, Tomoko Shiroma, Tatsuya Kariya, Ryo Nakao, Yuma Ohari, Kei Hayashi, Shinya Fukumoto
The number of wild sika deer (Cervus nippon yesoensis) continues to increase in Hokkaido Prefecture, Japan. The major concern for the livestock industry is the transmission of pathogens between sika deer and cattle. Fasciolosis is an important disease that can occur in both animals. The aim of this study was to examine the possible mutual transmission of this disease in Hokkaido Prefecture. A total of 105 Fasciola flukes were obtained from sika deer and 96 from domestic cattle. The Fasciola flukes in Japan are reported to possess no mature sperm...
April 7, 2017: Parasitology International
https://www.readbyqxmd.com/read/28392984/non-native-molluscan-colonizers-on-deliberately-placed-shipwrecks-in-the-florida-keys-with-description-of-a-new-species-of-potentially-invasive-worm-snail-gastropoda-vermetidae
#14
Rüdiger Bieler, Camila Granados-Cifuentes, Timothy A Rawlings, Petra Sierwald, Timothy M Collins
Artificial reefs created by deliberately sinking ships off the coast of the Florida Keys island chain are providing new habitat for marine invertebrates. This newly developing fouling community includes the previously reported invasive orange tube coral Tubastraea coccinea and the non-native giant foam oyster Hyotissa hyotis. New SCUBA-based surveys involving five shipwrecks spanning the upper, middle, and lower Florida Keys, show T. coccinea now also established in the lower Keys and H. hyotis likewise extending to new sites...
2017: PeerJ
https://www.readbyqxmd.com/read/28386680/consequences-of-eye-fluke-infection-on-anti-predator-behaviours-in-invasive-round-gobies-in-kalmar-sound
#15
Henrik Flink, Jane W Behrens, P Andreas Svensson
Larvae of the eye fluke, Diplostomum, emerge from snails and infect fish by penetrating skin or gills, then move to the lens where they may impair the vision of the fish. For the fluke to reproduce, a bird must eat the infected fish, and it has been suggested that they therefore actively manipulate the fish's behaviour to increase the risk of predation. We found that round gobies Neogobius melanostomus, a species that was recently introduced to the Kalmar Sound of the Baltic Sea, had an eye fluke prevalence of 90-100%...
April 6, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28385589/lymphocyte-responses-of-rats-vaccinated-with-cdna-encoding-a-phosphoglycerate-kinase-of-fasciola-hepatica-fhpgk-and-f-hepatica-infection
#16
Agnieszka Wesołowska, Anna Zawistowska-Deniziak, Luke J Norbury, Przemysław Wilkowski, Anna M Pyziel, Wojciech Zygner, Halina Wędrychowicz
Lymphocyte responses in the blood, peritoneal fluid and both mesenteric and hepatic lymph nodes of cDNA-FhPGK/pCMV vaccinated and/or Fasciola hepatica infected rats of both sexes were investigated to provide an insight into the immune responses that develop in different body compartments. The immune response that developed in cDNA-FhPGK/pCMV vaccinated females contributed to partial protection against F. hepatica infection (54% reduction in fluke recovery), while more liver flukes were found in the livers and bile ducts of cDNA-FhPGK/pCMV vaccinated male rats than in unvaccinated animals (increase of 13%)...
April 3, 2017: Parasitology International
https://www.readbyqxmd.com/read/28385539/th1-th2-balance-in-the-liver-and-hepatic-lymph-nodes-of-vaccinated-and-unvaccinated-sheep-during-acute-stages-of-infection-with-fasciola-hepatica
#17
I L Pacheco, N Abril, N Morales-Prieto, M J Bautista, R Zafra, A Escamilla, M T Ruiz, A Martínez-Moreno, J Pérez
The expression of IFNγ and IL4 was quantified using q-PCR in the liver and hepatic lymph nodes (HLN) of sheep during early stages of infection with Fasciola hepatica (1, 3, 9 and 18days post-infection, dpi). A group of animals (Group 1) were vaccinated with Fasciola hepatica recombinant cathepsin L1 (FhCL1) in montanide 70 VG prior to infection, a second group (group 2) was used as infected control and a third (group 3) was used as uninfected control. To study vaccine efficacy three additional groups were sacrificed 19 weeks post-infection (group 4 immunized with CL1, group 5 with the adjuvant and group 6 was used as infected control)...
March 25, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28385538/the-prevalence-and-development-of-digenean-parasites-within-their-intermediate-snail-host-galba-truncatula-in-a-geographic-area-where-the-presence-of-calicophoron-daubneyi-has-recently-been-confirmed
#18
Rhys Aled Jones, Hefin Wyn Williams, Sarah Dalesman, Ayodeji Sinmidele, Rowan K Thomas, Peter M Brophy
During the past decade, rumen fluke (Calicophoron daubneyi) has established as a prominent parasite of livestock within numerous European countries. Its development and spread is enabled by the presence of its intermediate snail host G. truncatula. However, the dynamics of this stage of the C. daubneyi lifecycle is yet to be recorded in numerous northern European countries including the UK. Here, the prevalence of C. daubneyi along with F. hepatica, H. cylindracea and other parasites infecting G. truncatula snails on 10 Welsh farms was recorded using morphological and PCR techniques...
March 27, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28383466/relative-device-stability-of-anterior-vs-axillary-needle-decompression-for-tension-pneumothorax-during-casualty-movement-preliminary-analysis-of-a-human-cadaver-model
#19
Matthew L Leatherman, Jenny M Held, Laura M Fluke, Christian S McEvoy, Kenji Inaba, Daniel Grabo, Matthew J Martin, Angela S Earley, Robert L Ricca, Travis M Polk
BACKGROUND: Tension pneumothorax (tPTX) remains a significant cause of potentially preventable death in military and civilian settings. The current pre-hospital standard of care for tPTX is immediate decompression with a 14 gauge 8cm angiocatheter (14G AC); however, failure rates may be as high as 17-60%. Alternative devices, such as 10G AC, modified Veress needle (mVN) and laparoscopic trocar (LT), have shown to be potentially more effective in animal models; however, little is known about the relative insertional safety or mechanical stability during casualty movement...
April 5, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28372560/fish-sharing-as-a-risk-factor-for-opisthorchis-viverrini-infection-evidence-from-two-villages-in-north-eastern-thailand
#20
Parichat Saenna, Cameron Hurst, Pierre Echaubard, Bruce A Wilcox, Banchob Sripa
BACKGROUND: Foodborne trematodiasis (FBT) is a significant global health problem, with the liver flukes Opisthorchis viverrini, O. felineus, and Clonorchis sinensis contributing to half of the global burden of FBT. North-eastern Thailand where O. viverrini is endemic and un-cooked fish dishes remain an integral part of the food culture has the highest reported incidence of opisthorchiasis, including associated cholangiocarcinoma. Both food sharing and eating practices are potentially important factors in FTB, suggesting an important role for the social ecology of disease transmission in these rural communities...
April 4, 2017: Infectious Diseases of Poverty
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