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https://www.readbyqxmd.com/read/29782530/histone-methylation-changes-are-required-for-life-cycle-progression-in-the-human-parasite-schistosoma-mansoni
#1
David Roquis, Aaron Taudt, Kathrin K Geyer, Gilda Padalino, Karl F Hoffmann, Nancy Holroyd, Matt Berriman, Benoît Aliaga, Cristian Chaparro, Christoph Grunau, Ronaldo de Carvalho Augusto
Epigenetic mechanisms and chromatin structure play an important role in development. Their impact is therefore expected to be strong in parasites with complex life cycles and multiple, strikingly different, developmental stages, i.e. developmental plasticity. Some studies have already described how the chromatin structure, through histone modifications, varies from a developmental stage to another in a few unicellular parasites. However, this, to our knowledge, has never been done before in multicellular metazoan parasites...
May 21, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29779756/biliary-cystadenoma-associated-with-opisthorchis-viverrini-infection-in-a-domestic-cat-felis-catus
#2
Saruda Tiwananthagorn, Saralee Srivorakul, Varangpicha Khochakul, Kidsadagon Pringproa
A 12-year-old, female, domestic cat (Felis catus) presented with dehydration, emaciation, anorexia, and lethargy. The cat was unresponsive to medical treatment and euthanized; the carcass was submitted for pathological diagnosis. Necropsy revealed icteric mucous membranes. The liver was enlarged, with multinodular, cystic, white masses, 0.5-4.0 cm in diameter, scattered throughout. Microscopically, the biliary epithelium presented with a proliferation of multifocal cystic masses, occasionally with periodic acid-Schiff-positive fluid within the cysts...
May 5, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29779499/efficacy-of-artemisinin-naphthoquine-phosphate-against-schistosoma-haematobium-adult-flukes-dose-effect-relationship-and-tegumental-alterations
#3
S N El-Beshbishi, S El Bardicy, M Tadros, M Ayoub, A Taman
Schistosoma haematobium and Schistosoma mansoni infections have broadly overlapping geographical distributions. Praziquantel is the only treatment for human schistosomiasis, so drug tolerance and/or resistance are major concerns. Artemisinin-naphthoquine phosphate (CO-ArNp), an artemisinin-based combination therapy endorsed by the World Health Organization as a gold standard therapy for malaria, has also been identified as a promising treatment for S. mansoni. In this in vitro study, we tested the effect of 1-40 μg/ml CO-ArNp on S...
May 21, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29773143/sex-and-vaccination-insights-from-female-rats-vaccinated-with-juvenile-specific-proteases-from-fasciola-hepatica
#4
Agnieszka Wesołowska, Katarzyna Basałaj, Luke J Norbury, Alicja Sielicka, Halina Wędrychowicz, Anna Zawistowska-Deniziak
Most animal research is less evidence-based for females, with the majority of studies conducted on males. Since immune responses vary between males and females, sexual dimorphism in immunity contributes, among other things, to sex-based differences post-vaccination. However, the issue of sex effects in animal vaccine research is rarely considered in vaccine study design. Previously, we have evaluated the efficacy of cathepsin L3 (FhCL3-1 and FhCL3-2) and B3 proteases (FhCB3) from juvenile Fasciola hepatica as vaccines against fasciolosis in male rats...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772884/validation-of-a-spatial-liver-fluke-model-under-field-conditions-in-ireland
#5
Amalia Naranjo Lucena, María Pía Munita Corbalán, Ana María Martínez-Ibeas, Guy McGrath, Riona Sayers, Grace Mulcahy, Annetta Zintl
Fasciola hepatica is the causative agent of fasciolosis, a global disease of a wide range of mammals, particularly sheep and cattle. Liver fluke infection causes annual losses estimated at around €2.5 billion to livestock and food industries worldwide. Various models have been developed to define risk factors and predict exposure to this liver fluke in ruminants in European countries, most of them based exclusively on data from dairy herds. The aim of this study was to validate a published theoretical baseline risk map of liver fluke exposure and cluster maps in Ireland, by including further explanatory variables and additional herd types that are spatially more widespread...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772216/human-liver-fluke-opisthorchis-viverrini-trematoda-opisthorchiidae-in-central-myanmar-new-records-of-adults-and-metacercariae-identified-by-morphology-and-molecular-analysis
#6
Oranuch Sanpool, Win Pa Pa Aung, Rutchanee Rodpai, Wanchai Maleewong, Pewpan M Intapan
Opisthorchis-like metacercariae were found in cyprinoid fish, Puntius brevis, bought from markets in the Bago region, Central Myanmar. Adult worms recovered from experimentally-infected hamsters resembled Opisthorchis viverrini. DNA was extracted from adults and metacercariae. A portion of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and the internal transcribed spacer 2 (ITS2) regions were amplified using the polymerase chain reaction and then sequenced. The sequences confirmed that the flukes were O...
May 14, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29769113/thinking-beyond-opisthorchis-viverrini-for-risk-of-cholangiocarcinoma-in-the-lower-mekong-region-a-systematic-review-and-meta-analysis
#7
REVIEW
Jennifer A Steele, Carsten H Richter, Pierre Echaubard, Parichat Saenna, Virginia Stout, Paiboon Sithithaworn, Bruce A Wilcox
BACKGROUND: Cholangiocarcinoma (CCA) is a fatal bile duct cancer associated with infection by the liver fluke, Opisthorchis viverrini, in the lower Mekong region. Numerous public health interventions have focused on reducing exposure to O. viverrini, but incidence of CCA in the region remains high. While this may indicate the inefficacy of public health interventions due to complex social and cultural factors, it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of CCA...
May 17, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29761097/commentary-human-liver-flukes
#8
COMMENT
Monica Catarina Botelho, Francisco Almeida, Joachim Richter, Antonio Sarmento
No abstract text is available yet for this article.
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29758277/first-genetic-evidence-for-the-presence-of-the-rumen-fluke-paramphistomum-epiclitum-in-pakistan
#9
Qasim Ali, Imran Rashid, Muhammad Zubair Shabbir, Haroon Akbar, Kashif Shahzad, Kamran Ashraf, Neil Sargison, Umer Chaudhry
More than 70 species of the Superfamily Paramphistomoidea, have been identified in ruminants in different parts of the world. Most are pathogenic, causing amphistomosis. Adult flukes within this family have a predilection for the forestomach (rumen) or bile duct of the liver, where they may cause epithelial damage. Identification of adult Paramphistomum, Calicophoron, Gastrothylax and Fischoederius at the species level based on morphology requires specialised expertise, whereas molecular genetic marker analysis is more precise and transferable...
May 11, 2018: Parasitology International
https://www.readbyqxmd.com/read/29753338/clonorchis-sinensis-and-clonorchiasis-the-relevance-of-exploring-genetic-variation
#10
Daxi Wang, Neil D Young, Pasi K Korhonen, Robin B Gasser
Parasitic trematodes (flukes) cause substantial mortality and morbidity in humans. The Chinese liver fluke, Clonorchis sinensis, is one of the most destructive parasitic worms in humans in China, Vietnam, Korea and the Russian Far East. Although C. sinensis infection can be controlled relatively well using anthelmintics, the worm is carcinogenic, inducing cholangiocarcinoma and causing major suffering in ~15 million people in Asia. This chapter provides an account of C. sinensis and clonorchiasis research-covering aspects of biology, epidemiology, pathogenesis and immunity, diagnosis, treatment and control, genetics and genomics...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29747064/a-changing-child-welfare-workforce-what-worker-characteristics-are-valued-in-child-welfare
#11
Kristen Lwin, Barbara Fallon, Nico Trocmé, John Fluke, Faye Mishna
A child welfare system is responsible for making difficult decisions. Child welfare workers are charged with assessing and determining when a child is in need of protection, including when it is necessary to intervene on behalf of children when their caregivers' abilities and/or situation is deemed to put them at risk of abuse or neglect. Although the child welfare workforce in Ontario attended to an estimated 125,281 child maltreatment investigations in 2013, little is known about the skills, education, and experiences of these investigating workers...
May 7, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29743617/complete-mitochondrial-and-rdna-complex-sequences-of-important-vector-species-of-biomphalaria-obligatory-hosts-of-the-human-infecting-blood-fluke-schistosoma-mansoni
#12
Si-Ming Zhang, Lijing Bu, Martina R Laidemitt, Lijun Lu, Martin W Mutuku, Gerald M Mkoji, Eric S Loker
Using high throughput Illumina sequencing technology, we determined complete sequences for the mitochondrial genome (mitogenome) and nuclear ribosomal DNA (rDNA) complex for three African freshwater snail taxa within the genus Biomphalaria, B. pfeifferi, B. sudanica and B. choanomphala, and for two laboratory strains of B. glabrata originating from the Neotropics. Biomphalaria snails are obligate vectors of the blood fluke Schistosoma mansoni, a major etiologic agent of human intestinal schistosomiasis. Our data show that mitogenomes from African and Neotropical Biomphalaria are highly conserved...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29729677/evaluation-of-%C3%A2-vivir-mi-vida-to-improve-health-and-wellness-of-rural-dwelling-late-middle-aged-latino-adults-results-of-a-feasibility-and-pilot-study-of-a-lifestyle-intervention
#13
Stacey L Schepens Niemiec, Jeanine Blanchard, Cheryl L P Vigen, Jenny Martínez, Laura Guzmán, Alyssa Concha, Michelle Fluke, Mike Carlson
AimThe aim of this study was to determine the feasibility and efficacy of a culturally tailored lifestyle intervention, ¡Vivir Mi Vida! (Live My Life!). This intervention was designed to improve the health and well-being of high risk late middle-aged Latino adults and to be implemented in a rural primary care system. BACKGROUND: Rural-dwelling Latino adults experience higher rates of chronic disease compared with their urban counterparts, a disparity exacerbated by limited access to healthcare services...
May 6, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29721656/effects-of-miconazole-clotrimazole-and-praziquantel-combinations-against-the-liver-fluke-opisthorchis-felineus-in-vivo-and-in-vitro
#14
Maria Y Pakharukova, Yuri V Pakharukov, Viatcheslav A Mordvinov
The liver fluke Opisthorchis felineus (Rivolta, 1884) is the causative agent of opisthorchiasis felinea in Eurasia. Opisthorchiasis is a serious human and fish-eating animal's disease affecting bile ducts and the gall bladder. Currently, the main drug for specific therapy of opisthorchiasis is praziquantel. We have previously shown that azole inhibitors of O. felineus cytochrome P450 significantly reduced survival of the worms in vitro. Here, we studied in vitro anthelmintic effects of drug combinations involving azole substances approved by the US Food and Drug Administration together with praziquantel against adult or juvenile O...
May 2, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29713629/helminths-and-cancers-from-the-evolutionary-perspective
#15
REVIEW
Larissa L S Scholte, Marcelo A Pascoal-Xavier, Laila A Nahum
Helminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes ( Schistosoma haematobium, Schistosoma japonicum , and Schistosoma mansoni ) and liver flukes ( Clonorchis sinensis and Opisthorchis viverrini ) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Our main goals are to summarize the current knowledge of human cancers caused by Platyhelminthes, point out some helminth and human biomarkers identified so far, and highlight the potential contributions of phylogenetics and molecular evolution to cancer research...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29707742/dna-sequences-confirm-low-specificity-to-definitive-host-and-wide-distribution-of-the-cat-pathogen-platynosomum-illiciens-p-fastosum-trematoda-dicrocoeliidae
#16
Hudson A Pinto, Eduardo A Pulido-Murillo, Roberta R Braga, Vitor L T Mati, Alan L Melo, Vasyl V Tkach
Although feline platynosomosis has been commonly reported in several parts of the world, the taxonomy and epidemiological chain related to cat liver flukes remain controversial. In this study, nuclear ribosomal ITS, 28S, and mitochondrial cox1 sequences obtained for Platynosomum illiciens from cat, marmoset, lizard, and snail found naturally infected in Brazil reveal no significant molecular differences between these isolates. Moreover, sequence data confirm that Brazilian P. illiciens from different hosts is conspecific with parasites obtained from cats in Vietnam, supporting wide distribution of the species...
April 29, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29705791/biliary-tract-cancer-implicated-immune-mediated-pathways-and-their-associated-potential-targets
#17
Noor-Ul-Ain Tariq, Arndt Vogel, Mairead G McNamara, Juan W Valle
There is a well-established link between biliary tract cancers (BTC) and chronic inflammatory conditions such as primary sclerosing cholangitis, chronic cholecystitis, chronic cholelithiasis, liver fluke-associated infestations, and chronic viral hepatic infections. These associated risk factors highlight the potential for development of immune-modulatory agents in this poor-prognostic disease group with limited treatment options. Clinical trials have evaluated the role of immune cells, inflammatory biomarkers, vaccines, cytokines, adoptive cell therapy, and immune checkpoint inhibitors in patients with BTC...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29705144/brachylaima-asakawai-sp-nov-trematoda-brachylaimidae-a-rodent-intestinal-fluke-in-hokkaido-japan-with-a-finding-of-the-first-and-second-intermediate-hosts
#18
Minoru Nakao, Mizuki Sasaki, Tsukasa Waki, Jason L Anders, Hirotaka Katahira
In the 1970's and 1980's, an unknown species of the genus Brachylaima (Trematoda: Brachylaimidae) had been recorded from the intestines of Rattus norvegicus and Apodemus speciosus in Hokkaido, Japan. The rodent fluke was characteristic in extending a bilateral vitellarium till the level of posterior margin of anterior testis and in keeping almost the same-sized spherical ovary and testes. In this study, the rodent fluke was rediscovered from A. speciosus, Apodemus argenteus, and Myodes rufocanus in Hokkaido...
April 26, 2018: Parasitology International
https://www.readbyqxmd.com/read/29704470/temperature-preference-of-cave-and-surface-populations-of-astyanax-mexicanus
#19
Julius A Tabin, Ariel Aspiras, Brian Martineau, Misty Riddle, Johanna Kowalko, Richard Borowsky, Nicolas Rohner, Clifford J Tabin
Little is known about the genetic basis of behavioral choice, such as temperature preference, especially in natural populations. Thermal preference can play a key role in habitat selection, for example in aquatic species. Examining this behavior on a genetic level requires access to individuals or populations of the same species that display distinct temperature preferences. Caves provide a uniquely advantageous setting to tackle this problem, as animals colonizing caves encounter an environment that generally has a different, and far more stable, annual temperature than what is encountered on the outside...
April 25, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29702654/identification-and-characterization-of-the-fasciola-hepatica-sodium-and-chloride-dependent-taurine-transporter
#20
Bulut Hamali, Sandra Pichler, Elisabeth Wischnitzki, Klaus Schicker, Melanie Burger, Marion Holy, Kathrin Jaentsch, Martina Molin, Eva Maria Sehr, Oliver Kudlacek, Michael Freissmuth
The parasitic liver fluke Fasciola hepatica infests mainly ruminants, but it can also cause fasciolosis in people, who ingest the metacercariae encysted on plants. The drug of choice to treat fasciolosis is triclabendazole (TBZ), which has been on the market for several decades. This is also true for the other available drugs. Accordingly, drug-resistant flukes have been emerging at an increasing rate making it desirable to identify alternative drug targets. Here, we focused on the fact that adult F. hepatica persists in the hostile environment of the bile ducts of infected organisms...
April 27, 2018: PLoS Neglected Tropical Diseases
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