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https://www.readbyqxmd.com/read/28069407/a-historical-review-of-small-liver-fluke-infections-in-humans
#1
EDITORIAL
Banchob Sripa, Smarn Tesana, Nataliya Yurlova, Yukifumi Nawa
No abstract text is available yet for this article.
January 6, 2017: Parasitology International
https://www.readbyqxmd.com/read/28069287/feline-cholangitis
#2
REVIEW
Lara Boland, Julia Beatty
Cholangitis is common in felines, including neutrophilic, lymphocytic, and chronic cholangitis (liver fluke). History, physical examination, laboratory testing, and abdominal ultrasound support a diagnosis. Diagnosis using hepatic histopathology and/or bile analysis is ideal but not always practical. Neutrophilic cholangitis is associated with bacterial cholecystitis, pancreatitis, and inflammatory bowel disease. The typical presentation is a short illness with lethargy, inappetence, pyrexia, and jaundice. Lymphocytic cholangitis, suspected to be immune-mediated, can have a prolonged clinical course with weight loss and ascites as the predominant features...
January 6, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28069074/a-next-generation-microarray-further-reveals-stage-enriched-gene-expression-pattern-in-the-blood-fluke-schistosoma-japonicum
#3
Pengfei Cai, Shuai Liu, Xianyu Piao, Nan Hou, Hong You, Donald P McManus, Qijun Chen
BACKGROUND: Schistosomiasis is caused by infection with blood flukes of the genus Schistosoma, and ranks, in terms of disability-adjusted life years (DALYs), as the third most important neglected tropical disease. Schistosomes have several discrete life stages involving dramatic morphological changes during their development, which require subtle gene expression modulations to complete the complex life-cycle. RESULTS: In the current study, we employed a second generation schistosome DNA chip printed with the most comprehensive probe array for studying the Schistosoma japonicum transcriptome, to explore stage-associated gene expression in different developmental phases of S...
January 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28060841/genomes-of-fasciola-hepatica-from-the-americas-reveal-colonization-with-neorickettsia-endobacteria-related-to-the-agents-of-potomac-horse-and-human-sennetsu-fevers
#4
Samantha N McNulty, Jose F Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H Mann, Lakshmi Kammili, Patricia S Latham, Nicolas Dell'Oca, Fernanda Dominguez, Carlos Carmona, Peter U Fischer, Paul J Brindley, Makedonka Mitreva
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domestic ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle...
January 6, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28058535/molecular-and-structural-characteristics-of-multidrug-resistance-associated-protein-7-in-chinese-liver-fluke-clonorchis-sinensis
#5
Fuhong Dai, Won Gi Yoo, Ji-Yun Lee, Yanyan Lu, Jhang Ho Pak, Woon-Mok Sohn, Sung-Jong Hong
Multidrug resistance-associated protein 7 (MRP7, ABCC10) is a C subfamily member of the ATP-binding cassette (ABC) superfamily. MRP7 is a lipophilic anion transporter that pumps endogenous and xenobiotic substrates from the cytoplasm to the extracellular milieu. Here, we cloned and characterized CsMRP7 as a novel ABC transporter from the Chinese liver fluke, Clonorchis sinensis. Full-length cDNA of CsMRP7 was 5174 nt, encoded 1636 amino acids (aa), and harbored a 147-bp 5'-untranslated region (5'-UTR) and 116-bp 3'-UTR...
January 5, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28048751/mo-de-bra-04-hands-on-fluoroscopy-safety-training-with-real-time-patient-and-staff-dosimetry
#6
M Vanderhoek, N Bevins
PURPOSE: Fluoroscopically guided interventions (FGI) are routinely performed across many different hospital departments. However, many involved staff members have minimal training regarding safe and optimal use of fluoroscopy systems. We developed and taught a hands-on fluoroscopy safety class incorporating real-time patient and staff dosimetry in order to promote safer and more optimal use of fluoroscopy during FGI. METHODS: The hands-on fluoroscopy safety class is taught in an FGI suite, unique to each department...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046912/su-f-e-04-a-paris-system-based-implant-approach-to-hyperthermia-cancer-tumor-with-gold-seeds-and-ultrasound
#7
C Austerlitz, A Barros, I Gkigkitzis, I Haranas, D Zhu, D Campos
PURPOSE: To apply the Paris system-based implant for an uniform bio-heat distribution from implanted gold rods in tissue insonated with ultrasound. METHODS: Experiments with single-plane implants using parallel equidistant 1.018 ± 0.015 cm height and 0.136 ± 0.001 cm diameter 24-K gold rods) arranged in triangular and square shapes were performed in Mus Musculus white mice (medial dorsal region). The mice were anesthetized and gold rods were implanted by means of a trocar needle and the implanted region was insonated with a 4-cm diameter transducer oscillating with a nominal frequency of 1 MHz and power of about 75 W...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046358/su-f-t-653-radiation-exposure-from-cs-131-permanent-seed-implants
#8
T Giaddui, M Hardin, D To, E Kremmel, C Peng, P Hann, S Richardson, Y Yu, A Harrison, L Doyle
PURPOSE: Permanent seed implants have traditionally been used to treat prostate, lung and head or neck cancers using I-125 and Pd-103. Cs-131, which has higher dose rate is being used to treat brain, head and/or neck cancers in our clinic, therefore, we chose to monitor the dose received by surgeons during the extensive procedure. The aims of this work are to assess the level of radiation exposure to surgeons and the instantaneous exposure at bedside and 1 m from patients. METHODS: Ten patients received Cs-131 implants for recurrent brain,head and/or neck cancer; the median implanted activity, number of implanted seeds and prescription dose at 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040375/-epi-genetic-inheritance-in-schistosoma-mansoni-a-systems-approach
#9
REVIEW
Céline Cosseau, Olaf Wolkenhauer, Gilda Padalino, Kathrin K Geyer, Karl F Hoffmann, Christoph Grunau
The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by 'inheritance system'. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success...
December 28, 2016: Trends in Parasitology
https://www.readbyqxmd.com/read/28024953/immune-protection-conferred-by-recombinant-mrlc-myosin-regulatory-light-chain-antigen-in-titermax-gold%C3%A2-adjuvant-against-experimental-fasciolosis-in-rats
#10
Luan C Henker, Claiton I Schwertz, Neuber J Lucca, Manoela M Piva, Keila C Prior, Piotr Baska, Luke Norbury, Kamil Januszkiewicz, Diogenes Dezen, Marta M M F Duarte, Rafael N Moresco, Liana Bertagnolli da Rosa, Ricardo E Mendes
Protection against experimental fasciolosis in rats immunized with recombinant myosin regulatory light chain (MRLC) in TiterMax Gold® adjuvant was assessed. The experimental trial consisted of four groups of 15 animals; group 1 was unimmunized and infected, group 2 was immunized with MRLC in adjuvant and infected, group 3 was infected and immunized with adjuvant only and group 4 was unimmunized and uninfected. Immunization with MRLC in TiterMax Gold® adjuvant (group 2) induced a reduction in fluke burdens of 51...
December 23, 2016: Vaccine
https://www.readbyqxmd.com/read/28018158/estrogen-catechols-detection-as-biomarkers-in-schistosomiasis-induced-cancer-and-infertility
#11
M C Botelho, H Alves, J Richter
Urogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations...
2017: Letters in Drug Design & Discovery
https://www.readbyqxmd.com/read/28003567/a-new-species-of-spirorchis-maccallum-1918-digenea-schistosomatoidea-and-spirorchis-cf-scripta-from-chicken-turtle-deirochelys-reticularia-emydidae-with-an-emendation-and-molecular-phylogeny-of-spirorchis
#12
Jackson R Roberts, Raphael Orelis-Ribeiro, Kenneth M Halanych, Cova R Arias, Stephen A Bullard
Chicken turtles, Deirochelys reticularia (Latreille in Sonnini et Latreille) (Testudines: Emydidae) from Alabama, USA were infected by Spirorchis collinsi Roberts et Bullard sp. n. and Spirorchis cf. scripta. The new species is most easily differentiated from its congeners by the combination of having caeca that extend far beyond the genitalia, intercaecal genitalia positioned in the middle portion of the body, a testicular column that nearly abuts the caecal bifurcation, a cirrus sac positioned between the testes and ovary, a massive Mehlis' gland, an elongate, longitudinal metraterm that extends anteriad beyond the level of the ovary, a pre-ovarian genital pore, and a prominent, intercaecal Manter's organ...
December 20, 2016: Folia Parasitologica
https://www.readbyqxmd.com/read/28003149/elucidation-of-the-first-definitively-identified-life-cycle-for-a-marine-turtle-blood-fluke-trematoda-spirorchiidae-enables-informed-control
#13
Thomas H Cribb, Jose L Crespo-Picazo, Scott C Cutmore, Brian A Stacy, Phoebe A Chapman, Daniel García-Párraga
Blood flukes of the family Spirorchiidae are significant pathogens of both free-ranging and captive marine turtles. Despite a significant proportion of marine turtle mortality being attributable to spirorchiid infections, details of their life cycles remain almost entirely unknown. Here we report on the molecular elucidation of the complete life cycle of a marine spirorchiid, identified as Amphiorchis sp., infecting vermetid gastropods and captive hatched neonate Caretta caretta in the Oceanogràfic Aquarium, in Valencia, Spain...
December 18, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27989833/identification-and-characterization-of-protein-14-3-3-in-carcinogenic-liver-fluke-opisthorchis-viverrini
#14
Alok Kafle, Pranom Puchadapirom, Sirikanya Plumworasawat, Rieofarng Dontumprai, Waraporn Chan-On, Sureemas Buates, Thewarach Laha, Banchob Sripa, Sutas Suttiprapa
Protein 14-3-3s are abundant phospho-serine/threonine binding proteins, which are highly conserved among eukaryotes. Members of this protein family mediate metabolism and signal transduction networks through binding to hundreds of other protein partners. Protein 14-3-3s have been studied in other species of parasitic helminthes, but little is known about this protein in the carcinogenic liver fluke Opisthorchis viverrini. In this study, we identified and characterized protein 14-3-3s of O. viverrini. Seven protein 14-3-3 encoded sequences were retrieved from the O...
October 27, 2016: Parasitology International
https://www.readbyqxmd.com/read/27987283/non-necrotizing-colonic-granuloma-induced-by-schistosomiasis
#15
Thein Swe, Aama Baqui, Akari Thein Naing, Tajruba Baqui, Jagannath Sherigar, Mohamed Mansour
Schistosomiasis is an important parasitic disease with various clinical presentations caused by trematode blood flukes. It can present with asymptomatic, chronic colonic ulcerations, strictures, or inflammatory mass causing bowel obstruction. Intestinal polyps are uncommon and induced by antigens released from the schistosome eggs that trigger a cell-mediated inflammatory response with granuloma formation involving T cells, macrophages, and necrosis. This is very relevant while evaluating chronic intermittent gastrointestinal symptoms and eosinophilia in an immigrant patient from endemic areas of schistosomiasis...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27956092/ultrasonographic-features-of-hepatobiliary-in-opisthorchiasis
#16
Eimorn Mairiang
Infection with the liver fluke, Opisthorchis viverrini (OV), is an important public health problem in northeast Thailand where people have a habit of eating raw or inadequately cooked fish. Opisthorchiasis Is associated with a number of asymptomatic hepatobiliary abnormalities and cholangiocarcinoma (CCA) that can be observed conveniently by ultrasonography. The ultrasonographicclassification of hepatobiliary pathology opisthorchiasis will be presented.
December 9, 2016: Parasitology International
https://www.readbyqxmd.com/read/27940066/fasciola-hepatica-demonstrates-high-levels-of-genetic-diversity-a-lack-of-population-structure-and-high-gene-flow-possible-implications-for-drug-resistance
#17
Nicola J Beesley, Diana J L Williams, Steve Paterson, Jane Hodgkinson
Fasciola hepatica, the liver fluke, is a trematode parasite of considerable economic importance to the livestock industry and is a re-emerging zoonosis that poses a risk to human health in F. hepatica-endemic areas worldwide. Drug resistance is a substantial threat to the current and future control of F. hepatica, yet little is known about how the biology of the parasite influences the development and spread of resistance. Given that F. hepatica can self-fertilise and therefore inbreed, there is the potential for greater population differentiation and an increased likelihood of recessive alleles, such as drug resistance genes, coming together...
December 7, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27939972/opisthorchiasis-in-western-siberia-epidemiology-and-distribution-in-human-fish-snail-and-animal-populations
#18
Natalia I Yurlova, Elena N Yadrenkina, Natalia M Rastyazhenko, Elena А Serbina, Viktor V Glupov
Opisthorchiasis is a widespread helminth infection in Russia. The largest opisthorchiasis endemic focus in the world is the Ob river watershed in Western Siberia. The main causative agent of this condition is the liver fluke, Opisthorchis felineus. In addition, another liver fluke species in the Opisthorchiidae family, Metorchis bilis, causes a symptomatically similar disease, metorchiasis. Despite a long research history going back to 1927, opisthorchiasis remains a serious problem in Russia, and numerous questions related to the epidemiology of these liver fluke infections and their patterns of distribution in Western Siberia, the causes of high prevalence in different populations, and the prognosis of the epidemiological situation remain to be answered...
December 8, 2016: Parasitology International
https://www.readbyqxmd.com/read/27939296/risk-factors-for-clonorchis-sinensis-infection-transmission-in-humans-in-northern-vietnam-a-descriptive-and-social-network-analysis-study
#19
Hoang Quang Vinh, Waraphon Phimpraphai, Sirikachorn Tangkawattana, John F Smith, Sasithorn Kaewkes, Do Trung Dung, Tran Thanh Duong, Banchob Sripa
Clonorchis sinensis is major fish-borne trematode, endemic in North Vietnam. Risk factors described so far include individual eating behaviors and environmental factors. Here, additional to conventional risk factors, we report on socially influenced liver fluke transmission in endemic communities. A cross-sectional study on risk factors and fish sharing networks was conducted in 4 villages of Gia Thinh Commune, Ninh Binh Province. A total of 510 residents in 272 households were recruited for risk factor analysis while 220 households, 28 fishermen and 10 fish-sellers were enrolled for social network study...
December 7, 2016: Parasitology International
https://www.readbyqxmd.com/read/27938792/surveillance-in-cholangiocellular-carcinoma
#20
REVIEW
Thomas C Wirth, Arndt Vogel
Cholangiocellular carcinoma is the most frequent malignant neoplasm originating from the epithelium of intra- or extrahepatic bile ducts. In the past decades, the incidence of cholangiocarcinoma has been shown to increase while overall mortality has remained high with an approximate 5-year overall survival below 20%. Surgery remains the only curative option while systemic treatment is limited to palliative chemotherapy. Therefore, surveillance strategies for patients at risk of developing cholangiocarcinoma are urgently needed, particularly in patients with primary sclerosing cholangitis and patients infected with liver flukes...
December 2016: Best Practice & Research. Clinical Gastroenterology
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