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https://www.readbyqxmd.com/read/29786974/embryonic-exposure-to-environmentally-relevant-concentrations-of-a-brominated-flame-retardant-reduces-the-size-of-song-control-nuclei-in-a-songbird
#1
Margaret L Eng, Viktoria Winter, John E Elliott, Scott A MacDougall-Shackleton, Tony D Williams
Environmental contaminants have the potential to act as developmental stressors and impair development of song and the brain of songbirds, but they have been largely unstudied in this context. 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) is a brominated flame retardant congener that has demonstrated endocrine disrupting effects, and has pervaded the global environment. We assessed the effects of in ovo exposure to environmentally relevant levels of BDE-99 on the neuroanatomy of the song-control system in a model songbird species, the zebra finch (Taeniopygia guttata)...
May 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29786821/cardiac-findings-of-sternal-fractures-due-to-thoracic-trauma-a-five-year-retrospective-study
#2
Ahmet Uluşan, Özgür Karakurt
BACKGROUND: This study mainly aimed to determine the frequency of sternal fractures in thoracic trauma patients and to assess the differences in surgical need, cardiac findings, and treatment processes between patients with fracture on different sternal zones and displaced and non-displaced sternal fractures. METHODS: We analyzed the data of patients with sternal fracture due to thoracic trauma admitted to a state hospital between January 2011 and December 2015...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786816/examination-of-morbidity-and-mortality-of-cases-according-to-intra-vehicle-position-and-accident-mechanism
#3
Orhan Meral, Ekin Özgür Aktaş, Murat Ersel
BACKGROUND: Traffic accidents are still an important public health issue in our country and intra-vehicle accidents cause substantial morbidity and mortality. In this study, we aimed to investigate the effect of seating position on morbidity and mortality in traffic accidents. METHODS: Patients who were admitted to the Emergency Department, Faculty of Medicine, Ege University between May 1, 2014 and November 30, 2014 due to injuries in motor vehicles and who signed informed consent were included...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786584/effect-of-atmospheric-technogenic-emissions-on-health-indicators-of-child-population
#4
Olha M Toronchenko, Viktor I Bredun, Natalia O Smoliar
OBJECTIVE: Introduction:The identification of scientifically grounded dependency of the atmospheric pollution effect on the health level of the child population within particular area makes it possible to assess the degree of district environmental safety and provides the possibility for implementation of targeted programs and risk preventing strategies associated with atmospheric emissions. The aim of the study is to assess the dependence of child morbidity rate development caused by atmospheric chemical pollution, which resulted from the stationary and mobile sources activity in terms of the Poltava region (Ukraine) as a model...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29785783/silica-gelatin-hybrid-sol-gel-coatings-a-proteomic-study-with-biocompatibility-implications
#5
N Araújo-Gomes, F Romero-Gavilán, I Lara-Sáez, F Elortza, M Azkargorta, I Iloro, M Martínez-Ibañez, J J Martín de Llano, M Gurruchaga, I Goñi, J Suay, A M Sánchez-Pérez
Osseointegration, including the foreign body reaction to biomaterials, is an immune-modulated, multifactorial, and complex healing process in which various cells and mediators are involved. The buildup of the osseointegration process is immunological and inflammation-driven, often triggered by the adsorption of proteins on the surfaces of the biomaterials and complement activation. New strategies for improving osseointegration use coatings as vehicles for osteogenic biomolecules delivery from implants. Natural polymers, such as gelatin, can mimic collagen I and enhance the biocompatibility of a material...
May 21, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29785638/intermittent-convection-enhanced-delivery-of-gdnf-into-rhesus-monkey-putamen-absence-of-local-or-cerebellar-toxicity
#6
Matthias Luz, Philip C Allen, John Bringas, Chris Boiko, Diane E Stockinger, Kristen J Nikula, Owen Lewis, Max Woolley, H Christian Fibiger, Krystof Bankiewicz, Erich Mohr
Glial cell line-derived neurotrophic factor (GDNF) has demonstrated neurorestorative and neuroprotective effects in rodent and nonhuman primate models of Parkinson's disease. However, continuous intraputamenal infusion of GDNF (100 µg/day) resulted in multifocal cerebellar Purkinje cell loss in a 6-month toxicity study in rhesus monkeys. It was hypothesized that continuous leakage of GDNF into the cerebrospinal fluid compartment during the infusions led to down-regulation of GDNF receptors on Purkinje cells, and that subsequent acute withdrawal of GDNF then mediated the observed cerebellar lesions...
May 22, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29785490/microcirculatory-effects-of-sildenafil-in-experimental-testicular-torsion-in-rats
#7
Márton Oroszi, Andrea Szabó, Ádám Miklós Fehér, Gábor Deák, Zoltán Bajory
PURPOSE: Investigate the short-term effect of sildenafil on microcirculation, especially the velocity, the pattern of the flow and the recruitment of the leukocyte in postcapillaries. METHODS: In male Sprague-Dawley rats, the microcirculatory consequences of 60 min experimental testicular torsion, followed by 240 min of reperfusion, were examined. Using fluorescence intravital microscopy, changes in red blood cell velocity in post-capillary venules and rolling as well as adhesion of leukocytes in the postcapillary venules were examined before the torsion and every hour during the reperfusion period...
May 21, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29785414/topical-nasal-decongestant-oxymetazoline-0-05-provides-relief-of-nasal-symptoms-for-12-hours
#8
H M Druce, D L Ramsey, S Karnati, A N Carr
BACKGROUND: Nasal congestion, often referred to as stuffy nose or blocked nose is one of the most prevalent and bothersome symptoms of an upper respiratory tract infection. Oxymetazoline, a widely used intranasal decongestant, offers fast symptom relief, but little is known about the duration of effect. METHODOLOGY: The results of 2 randomized, double-blind, vehicle-controlled, single-dose, parallel, clinical studies (Study 1, n=67; Study 2, n=61) in which the efficacy of an oxymetazoline (0...
May 22, 2018: Rhinology
https://www.readbyqxmd.com/read/29785378/delayed-presentation-of-grade-iv-renal-injury-post-blunt-trauma
#9
J Teh, M Khan, D Liu, J Roberts-Thomson
High-grade renal injuries are relatively uncommon in blunt trauma. They typically occur in the context of multisystem injuries. When present, these renal injuries are usually identified at the time of hospital presentation. Here, we present a case of delayed presentation of American Association for the Surgery of Trauma (AAST) grade-IV renal injury in a 61-year-old female who sustained multisystem injuries during a high-speed motor vehicle accident. To our knowledge, this is the first report case of delayed presentation of grade-IV renal injury...
May 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29785236/the-efficacy-of-a-ceramide-based-cream-in-mild-to-moderate-atopic-dermatitis
#10
Zoe Diana Draelos, Isabelle Raymond
Objective: The goal of this study was to determine if a therapeutic cream containing PC-104 synthetic ceramides and other ingredients could help to ameliorate signs and symptoms of mild-to-moderate atopic dermatitis and other xerotic or pruritic dermatoses. Design: In this single-site, four-week study, subjects (n=50) were instructed to apply the study product three times daily to all affected areas, including a target site for evaluation and photography at baseline, Week 2, and Week 4 visits. Setting: This study took place in the private practice of the senior author...
May 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29785204/using-digital-health-to-enable-ethical-health-research-in-conflict-and-other-humanitarian-settings
#11
REVIEW
Eric D Perakslis
Conducting research in a humanitarian setting requires quantifiable quality measures to ensure ethical study conduct. Digital health technologies are proven to improve research study quality and efficacy via automated data collection, improvement of data reliability, fidelity and resilience and by improved data provenance and traceability. Additionally, digital health methodologies can improve patient identity, patient privacy, study transparency, data sharing, competent informed consent, and the confidentiality and security of humanitarian operations...
2018: Conflict and Health
https://www.readbyqxmd.com/read/29785143/pilot-study-of-the-antifibrotic-effects-of-the-multikinase-inhibitor-pacritinib-in-a-mouse-model-of-liver-fibrosis
#12
Suliman Al-Fayoumi, Taishi Hashiguchi, Yuka Shirakata, John Mascarenhas, Jack W Singer
Background: Fibrotic diseases result from an exuberant response to chronic inflammation. Myelofibrosis is the end result of inflammation in bone, caused by an inflammatory process triggered by production of abnormal myeloid cells driven by mutations affecting the JAK-STAT pathway. Inflammatory cytokine overproduction leads to increased mesenchymal cell proliferation, culminating in fibrosis. Although JAK2 inhibitors, such as the JAK1/2 inhibitor ruxolitinib and the JAK2/FLT3/CSF1R/IRAK1 inhibitor pacritinib suppress abnormal clone expansion in myelofibrosis, ruxolitinib does not appear to prevent or reverse bone-marrow fibrosis in most patients...
2018: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/29784857/cytosolic-delivery-of-multi-domain-cargos-by-the-n-terminus-of-pasteurella-multocida-toxin
#13
Nathan C Clemons, Yuka Bannai, Elizabeth E Haywood, Yiting Xu, James D Buschbach, Mengfei Ho, Brenda A Wilson
The zoonotic pathogen Pasteurella multocida produces a 146-kDa modular toxin (PMT) that enters host cells and manipulates intracellular signaling through action on its Gα-protein targets. The N-terminus of PMT (PMT-N) mediates cellular uptake through receptor-mediated endocytosis, followed by delivery of the C-terminal catalytic domain from acidic endosomes into the cytosol. The putative native cargo of PMT consists of a 710-residue polypeptide of three distinct modular subdomains (C1-C2-C3), where C1 contains a membrane localization domain (MLD), C2 has as-of-yet undefined function, and C3 catalyzes deamidation of a specific active-site glutamine residue in Gα-protein targets...
May 21, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29784663/involvement-of-nicotinic-receptor-subtypes-in-behavioral-effects-of-nicotinic-drugs-in-squirrel-monkeys
#14
Sarah Louise Withey, Michelle R Doyle, Jack Bergman, Rajeev I Desai
Evidence suggests that the α4β2, but not the α7, subtype of nicotinic acetylcholine receptor (nAChR) plays a key role in mediating the behavioral effects of nicotine and related drugs. However, the importance of other nAChR subtypes remains unclear. The present studies were conducted to examine the involvement of nAChR subtypes by determining the effects of selected nicotinic agonists and antagonists in squirrel monkeys: a) responding for food-reinforcement; or b) discriminating the nicotinic agonist (+)-epibatidine (0...
May 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29784661/linaclotide-attenuates-visceral-organ-crosstalk-role-of-guanylate-cyclase-c-activation-in-reversing-bladder-colon-cross-sensitization
#15
Ehsan N Mohammadi, Casey O Ligon, Ada Silos-Santiago, Pei Ge, Caroline Kurtz, Carolyn Higgins, Gerhard Hannig, Beverley Greenwood-Van Meerveld
INTRODUCTION: Bladder pain syndrome (BPS) is poorly understood, however there is evidence of a female predominance and co-morbidity with irritable bowel syndrome (IBS). Here we test the hypothesis that linaclotide, a guanylate cyclase-C (GC-C) agonist approved for the treatment of IBS with constipation (IBS-C), may represent a novel therapeutic for BPS acting through a mechanism involving an inhibition of visceral organ cross sensitization. METHODS: In female rats, infusion of dilute protamine sulfate (PS) into the bladder was employed to induce bladder and colonic hypersensitivity...
May 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29784448/injury-severity-analysis-of-commercially-licensed-drivers-in-single-vehicle-crashes-accounting-for-unobserved-heterogeneity-and-age-group-differences
#16
Mohamed Osman, Sabyasachee Mishra, Rajesh Paleti
This study analyzes the injury severity of commercially-licensed drivers involved in single-vehicle crashes. Considering the discrete ordinal nature of injury severity data, the ordered response modeling framework was adopted. The moderating effect of driver's age on all other factors was examined by segmenting the parameters by driver's age group. Additional effects of the different drivers' age groups are taken into consideration through interaction terms. Unobserved heterogeneity of the different covariates was investigated using the Mixed Generalized Ordered Response Probit (MGORP) model...
May 18, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29784418/transmission-infrared-imaging-microscopy-and-multivariate-curve-resolution-applied-to-the-forensic-examination-of-automotive-paints
#17
Francis Kwofie, Undugodage Don Nuwan Perera, Matthew D Allen, Barry K Lavine
In the forensic examination of automotive paint, each layer of paint is analyzed individually by infrared (IR) spectroscopy. Laboratories in North America typically hand section each layer and present each separated layer to the spectrometer for analysis, which is time consuming. In addition, sampling too close to the boundary between adjacent layers can pose a problem as it produces an IR spectrum that is a mixture of the two layers. Not having a "pure" spectrum of each layer will prevent a meaningful comparison between each paint layer or in the situation of searching an automotive database will prevent the forensic paint examiner from developing an accurate hit list of potential suspects...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784129/the-non-psychoactive-phytocannabinoid-cannabidiol-cbd-attenuates-pro-inflammatory-mediators-t-cell-infiltration-and-thermal-sensitivity-following-spinal-cord-injury-in-mice
#18
Hongbo Li, Weimin Kong, Christina R Chambers, Daohai Yu, Doina Ganea, Ronald F Tuma, Sara Jane Ward
We evaluated the effects of the non-psychoactive cannabinoid cannabidiol (CBD) on the inflammatory response and recovery of function following spinal cord injury (SCI). Female C57Bl/6 mice were exposed to spinal cord contusion injury (T9-10) and received vehicle or CBD (1.5 mg/kg IP) injections for 10 weeks following injury. The effect of SCI and CBD treatment on inflammation was assessed via microarray, qRT-PCR and flow cytometry. Locomotor and bladder function and changes in thermal and mechanical hind paw sensitivity were also evaluated...
March 8, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29783994/large-scale-transcriptomic-analysis-reveals-that-pridopidine-reverses-aberrant-gene-expression-and-activates-neuroprotective-pathways-in-the-yac128-hd-mouse
#19
Rebecca Kusko, Jennifer Dreymann, Jermaine Ross, Yoonjeong Cha, Renan Escalante-Chong, Marta Garcia-Miralles, Liang Juin Tan, Michael E Burczynski, Ben Zeskind, Daphna Laifenfeld, Mahmoud Pouladi, Michal Geva, Iris Grossman, Michael R Hayden
BACKGROUND: Huntington Disease (HD) is an incurable autosomal dominant neurodegenerative disorder driven by an expansion repeat giving rise to the mutant huntingtin protein (mHtt), which is known to disrupt a multitude of transcriptional pathways. Pridopidine, a small molecule in development for treatment of HD, has been shown to improve motor symptoms in HD patients. In HD animal models, pridopidine exerts neuroprotective effects and improves behavioral and motor functions. Pridopidine binds primarily to the sigma-1 receptor, (IC50 ~ 100 nM), which mediates its neuroprotective properties, such as rescue of spine density and aberrant calcium signaling in HD neuronal cultures...
May 21, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29783793/summary-of-u-s-injuries-and-fatalities-involving-entrapment-and-suffocation-in-grain-transport-vehicles
#20
Yuan-Hsin Cheng, William E Field, Salah F Issa, Kevin Kelley, Matthew Heber, Robert Turner
Since 1978, the Purdue University Agricultural Safety and Health Program has managed a surveillance effort and database to collect information on documented injuries and fatalities in all forms of U.S. agricultural confined spaces. The database currently contains 1,968 cases documented in the U.S. between 1964 and 2016. Of these cases, 174 (8.8%) involved entrapment or suffocation in grain transport vehicles (GTVs), including gravity-flow wagons, semi-truck trailers, and other agricultural transport vehicles that have limited access and are not considered normal work spaces or are classified as confined spaces...
May 7, 2018: Journal of Agricultural Safety and Health
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