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https://www.readbyqxmd.com/read/28945015/membrane-fusion-mediated-intracellular-delivery-of-lipid-bilayer-coated-mesoporous-silica-nanoparticles
#1
Jian Yang, Jing Tu, Gerda E M Lamers, René C L Olsthoorn, Alexander Kros
Protein delivery into the cytosol of cells is a challenging topic in the field of nanomedicine, because cellular uptake and endosomal escape are typically inefficient, hampering clinical applications. In this contribution cuboidal mesoporous silica nanoparticles (MSNs) containing disk-shaped cavities with a large pore diameter (10 nm) are studied as a protein delivery vehicle using cytochrome-c (cytC) as a model membrane-impermeable protein. To ensure colloidal stability, the MSNs are coated with a fusogenic lipid bilayer (LB) and cellular uptake is induced by a complementary pair of coiled-coil (CC) lipopeptides...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944864/halofuginone-attenuates-articular-cartilage-degeneration-by-inhibition-of-elevated-tgf%C3%A2-%C3%AE-1-signaling-in-articular-cartilage-in-a-rodent-osteoarthritis-model
#2
Wenbo Mu, Boyong Xu, Hairong Ma, Baochao Ji, Zhendong Zhang, Jiao Li, Abdusami Amat, Li Cao
Osteoarthritis (OA) is the most common degenerative condition of the weight‑bearing joints worldwide without effective medical therapy. In order to investigate whether administration of halofuginone (HF) may attenuate OA, the present study allocated 3‑month‑old male mice into Sham group, vehicle‑treated anterior cruciate ligament transection (ACLT) group and HF‑treated ACLT group. The present study determined that HF treatment reduced the expression of matrix metallopeptidase‑13 and collagen X in articular cartilage...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944599/resveratrol-suppresses-the-alveolar-bone-resorption-induced-by-artificial-trauma-from-occlusion-in-mice
#3
Y Matsuda, T Minagawa, T Okui, K Yamazaki
OBJECTIVE: Besides inflammatory bone loss, trauma from occlusion (TO)-induced alveolar bone loss increases the risk of future tooth loss. We have shown that resveratrol, a polyphenol, possesses anti-inflammatory characteristics and a suppressive effect on osteoclastogenesis. Therefore, we investigated the effects of resveratrol on TO-induced bone loss in mice. MATERIAL AND METHODS: TO was induced by overlaying composite resin onto the maxillary first molar of C57BL/6 mice...
September 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28944438/personal-exposure-and-health-risk-assessment-of-carbonyls-in-family-cars-and-public-transports-a-comparative-study-in-nanjing-china
#4
Huaizhou Xu, Qin Zhang, Ninghui Song, Min Guo, Shenghu Zhang, Guixiang Ji, Lili Shi
To evaluate passenger health risks associated with inhalation exposure to carbonyl compounds mainly emitted from decoration materials of vehicles, we tested the carbonyl concentrations in interior air of 20 family cars, 6 metro lines, and 5 buses in the city of Nanjing. To assess non-carcinogenic health risks, we compared the data to the health guidelines of China, US Environmental Protection Agency (EPA), and Office of Environmental Health Hazard Assessment (OEHHA), respectively. To assess carcinogenic risks, we followed a standard approach proposed by the OEHHA to calculate lifetime cancer risks (LCR) of formaldehyde and acetaldehyde for various age groups...
September 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28944309/particle-coatings-but-not-silver-ions-mediate-genotoxicity-of-ingested-silver-nanoparticles-in-a-mouse-model
#5
Sameera Nallanthighal, Cadia Chan, Dhruba J Bharali, Shaker A Mousa, Elizabeth Vásquez, Ramune Reliene
Incorporation of silver nanoparticles (AgNPs) in toothpaste, food containers, dietary supplements and other consumer products can result in oral exposure to AgNPs and/or silver ions (Ag(+)) released from the surface of AgNPs. To examine whether ingestion of AgNPs or Ag(+) results in genotoxic damage and whether AgNP coatings modulate the effect, we exposed mice orally to 20 nm citrate-coated AgNPs, polyvinylpyrrolidone (PVP)-coated AgNPs, silver acetate or respective vehicles at a 4 mg/kg dose (equivalent to 800x the EPA reference dose for Ag) for 7 days...
January 2017: NanoImpact
https://www.readbyqxmd.com/read/28944193/the-ocular-toxicity-and-pharmacokinetics-of-simvastatin-following-intravitreal-injection-in-mice
#6
Dennis Y Tse, Seong Jae Kim, Inyoung Chung, Feng He, Theodore G Wensel, Samuel M Wu
AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally injected into the right eye of each mouse; the left eye was injected with vehicle and was used as a control. Bilateral dark-adapted electroretinography (ERG) was performed 1 and 7d following injection. Histology was examined using a combination of light, fluorescence and electron microscopy...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28943942/honokiol-inhibits-bladder-cancer-cell-invasion-through-repressing-src-3-expression-and-epithelial-mesenchymal-transition
#7
Lan Shen, Fang Zhang, Ruimin Huang, Jun Yan, Bing Shen
Urinary bladder cancer (UBC) is one of the most common urological cancer types. Muscle invasive bladder cancer possesses high propensity for metastasis with poor prognosis. Honokiol is a lignan isolated from Magnolia officinalis with high bioavailability and potent anticancer effects. The results of the present study demonstrated that honokiol significantly inhibited UBC cell migration and invasion in a dose-dependent manner compared with the vehicle-treated control group. In addition, honokiol treatment suppressed epithelial-mesenchymal transition by induction of E-cadherin and repression of N-cadherin...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943209/a-novel-high-drug-loading-mussel-inspired-polydopamine-hybrid-nanoparticle-as-a-ph-sensitive-vehicle-for-drug-delivery
#8
Jie Hou, Chunlei Guo, Yuzhi Shi, Ergang Liu, Weibing Dong, Bo Yu, Shiyuan Liu, Junbo Gong
A novel high drug loading pH-cleavable polymer hybrid nanoparticle was prepared via doxorubicin (DOX) grafted onto PEGylated, mussel-inspired polydopamine (PDA) and then coated onto hollow silica nanoparticles for drug delivery. A series of characterization shed light on the formation mechanisms of PDA coatings on hollow silica. We hypothesized that dopamine was first absorbed onto the surface of hollow silica and then began self-polymerization. A Dox-containing thiol moiety was fabricated with conjugation between doxorubicin hydrochloride and Mercaptopropionyalkali with a pH-cleavable hydrozone bond...
September 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28943195/diels-alder-mediated-release-of-gemcitabine-from-hybrid-nanoparticles-for-enhanced-pancreatic-cancer-therapy
#9
Adeolu Oluwasanmi, Wejdan Al-Shakarchi, Ayesha Manzur, Mohammed H Aldebasi, Rayan S Elsini, Malek K Albusair, Katherine J Haxton, Anthony D M Curtis, Clare Hoskins
Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system was developed by introducing a linker between HNPs and gemcitabine. Whereby, heat generation resulting from laser irradiation of the HNPs promoted linker breakdown resulting in prodrug liberation. In vitro evaluation in pancreatic adenocarcinoma cells, showed the prodrug was 4...
September 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28942894/wavelet-based-information-filtering-for-fault-diagnosis-of-electric-drive-systems-in-electric-ships
#10
Andre A Silva, Shalabh Gupta, Ali M Bazzi, Arthur Ulatowski
Electric machines and drives have enjoyed extensive applications in the field of electric vehicles (e.g., electric ships, boats, cars, and underwater vessels) due to their ease of scalability and wide range of operating conditions. This stems from their ability to generate the desired torque and power levels for propulsion under various external load conditions. However, as with the most electrical systems, the electric drives are prone to component failures that can degrade their performance, reduce the efficiency, and require expensive maintenance...
September 21, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28942793/delivery-of-biomolecules-via-extracellular-vesicles-a-budding-therapeutic-strategy
#11
Devin M Stranford, Joshua N Leonard
Extracellular vesicles (EVs) are membrane-enclosed particles that are secreted by nearly all cells and play an important role in intercellular communication by transporting protein and nucleic acids between cells. EV-mediated processes shape phenomena as diverse as cancer progression, immune function, and wound healing. The natural role of EVs in encapsulating and delivering cargo to modify cellular function highlights the potential to use these particles as therapeutic delivery vehicles. In this chapter, we describe emerging strategies for EV engineering and consider how different approaches to EV production, purification, and design may impact the efficacy of EV-based therapeutics...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/28942222/the-effect-of-astragaloside-iv-on-ethanol-induced-gastric-mucosal-injury-in-rats-involvement-of-inflammation
#12
Shumin Qin, Keer Huang, Zhigang Fang, Jinjin Yin, Ruwei Dai
The present study aimed to investigate the potential protective effects of Astragaloside IV (AS-IV) against ethanol-induced gastric mucosal injury in rats. The animals were divided into 7 groups and pretreated with vehicle, various doses of AS-IV (1,2 and 4mg/kg, i.p.) or omeprazole (40mg/kg), 75min later, the gastric mucosal injury was induced by oral administration of ethanol. One hour after ethanol ingestion, the rats were euthanized and gastric tissues were collected to biochemical analyze. Myeloperoxidase (MPO), tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), interleukin 10 (IL-10), nuclear factor kappa B (NF-κB) p65 protein, TNF receptor-associated factor 2 (TRAF2) and nuclear NF-κB (nNF-κB) proteins were estimated by enzyme-linked immunosorbent assay or western blot analysis...
September 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28942043/modeling-pedestrian-crossing-speed-profiles-considering-speed-change-behavior-for-the-safety-assessment-of-signalized-intersections
#13
Miho Iryo-Asano, Wael K M Alhajyaseen
Pedestrian safety is one of the most challenging issues in road networks. Understanding how pedestrians maneuver across an intersection is the key to applying countermeasures against traffic crashes. It is known that the behaviors of pedestrians at signalized crosswalks are significantly different from those in ordinary walking spaces, and they are highly influenced by signal indication, potential conflicts with vehicles, and intersection geometries. One of the most important characteristics of pedestrian behavior at crosswalks is the possible sudden speed change while crossing...
September 21, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28942042/young-females-at-risk-while-driving-with-a-small-child
#14
Ida Maasalo, Esko Lehtonen, Heikki Summala
INTRODUCTION: Previous research suggests that young mothers with little driving experience are at risk when driving with a small child passenger. In this study we examined the prevalence, characteristics and risk of fatal motor vehicle crashes involving an infant passenger under the age of one among female drivers of different ages. METHODS: We used crash data from the US Fatality Analysis Reporting System for 1994-2013. The prevalence of fatal crashes involving infants was examined by age of female drivers and compared to the number of births among mothers of a similar age...
September 21, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28942006/effect-of-dronedarone-on-the-pharmacokinetics-of-carvedilol-following-oral-administration-to-rats
#15
Min-Soo Kim, In-Hwan Baek
Dronedarone is a CYP2D6 inhibitor; therefore, it is prudent to exercise caution when concurrently administering CYP2D6-metabolized β-blockers because of a lack of published data on potential drug interactions. The aim of this study was to investigate the effect of dronedarone on the pharmacokinetics of orally administered carvedilol in rats. Twenty male Sprague-Dawley rats were randomly divided into two groups and 10mg/kg carvedilol was administered to the rat with or without dronedarone pretreatment in a parallel design...
September 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28941995/neuropeptide-s-overcomes-short-term-memory-deficit-induced-by-sleep-restriction-by-increasing-prefrontal-cortex-activity
#16
Julien Thomasson, Frédéric Canini, Betty Poly-Thomasson, Marion Trousselard, Sylvie Granon, Frédéric Chauveau
Sleep restriction (SR) impairs short term memory (STM) that might be related to different processes. Neuropeptide S (NPS), an endogenous neuropeptide that improves short term memory, activates arousal and decreases anxiety is likely to counteract the SR-induced impairment of STM. The objective of the present study was to find common cerebral pathways in sleep restriction and NPS action in order to ultimately antagonize SR effect on memory. The STM was assessed using a spontaneous spatial alternation task in a T-maze...
September 20, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28941951/on-decentralized-adaptive-full-order-sliding-mode-control-of-multiple-uavs
#17
Xianbo Xiang, Chao Liu, Housheng Su, Qin Zhang
In this study, a novel decentralized adaptive full-order sliding mode control framework is proposed for the robust synchronized formation motion of multiple unmanned aerial vehicles (UAVs) subject to system uncertainty. First, a full-order sliding mode surface in a decentralized manner is designed to incorporate both the individual position tracking error and the synchronized formation error while the UAV group is engaged in building a certain desired geometric pattern in three dimensional space. Second, a decentralized virtual plant controller is constructed which allows the embedded low-pass filter to attain the chattering free property of the sliding mode controller...
September 20, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28941653/in-vitro-and-in-vivo-study-of-the-application-of-volvox-spheres-to-co-culture-vehicles-in-liver-tissue-engineering
#18
Siou Han Chang, Han Hsiang Huang, Pei Leun Kang, Yu Chian Wu, Ming-Huang Chang, Shyh Ming Kuo
Volvox sphere is a biomimetic concept of a natural Volvox, wherein a large outer sphere contains smaller inner spheres, which can encapsulate cells and provide a double-layer three-dimensional environment for culturing cells. This study simultaneously encapsulated rat mesenchymal stem cells (MSCs) and AML12 hepatocytes in volvox spheres and extensively evaluated the effects of various culturing modes on cell functions and fates. The results showed that compared with a static flask culture, MSCs encapsulated in volvox spheres differentiated into hepatocyte-like cells with a 2-fold increase in albumin (ALB) expression and a 2...
September 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28941652/silk-scaffolds-in-bone-tissue-engineering-an-overview
#19
REVIEW
Promita Bhattacharjee, Banani Kundu, Deboki Naskar, Hae-Won Kim, Tapas K Maiti, Debasis Bhattacharya, Subhas C Kundu
Bone tissue plays multiple roles in our day-to-day functionality. The frequency of accidental bone damage and disorder is increasing worldwide. Moreover, as the world population continues to grow, the percentage of the elderly population continues to grow, which results in an increased number of bone degenerative diseases. This increased elderly population pushes the need for artificial bone implants that specifically employ biocompatible materials. A vast body of literature is available on the use of silk in bone tissue engineering...
September 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28940885/high-energy-density-metal-oxygen-batteries-lithium-oxygen-batteries-vs-sodium-oxygen-batteries
#20
REVIEW
Kyeongse Song, Daniel Adjei Agyeman, Mihui Park, Junghoon Yang, Yong-Mook Kang
The development of next-generation energy-storage devices with high power, high energy density, and safety is critical for the success of large-scale energy-storage systems (ESSs), such as electric vehicles. Rechargeable sodium-oxygen (Na-O2 ) batteries offer a new and promising opportunity for low-cost, high-energy-density, and relatively efficient electrochemical systems. Although the specific energy density of the Na-O2 battery is lower than that of the lithium-oxygen (Li-O2 ) battery, the abundance and low cost of sodium resources offer major advantages for its practical application in the near future...
September 21, 2017: Advanced Materials
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