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https://www.readbyqxmd.com/read/29156710/the-synergistic-antitumor-effect-of-cinobufagin-and-cisplatin-in-human-osteosarcoma-cell-line-in-vitro-and-in-vivo
#1
Guo Dai, Ling Yu, Jian Yang, Kezhou Xia, Zhengpei Zhang, Gaiwei Liu, Tian Gao, Weichun Guo
Cisplatin (CDDP) has been shown to be a promising anticancer drug that is effective against many types of cancer, which include osteosarcoma (OS). However, its therapeutic application is restricted by its toxicity in normal tissues and by side effects caused in patients. Reduction of the toxicity of CDDP is necessary to improve cancer treatment. In the present study, we attempted to clarify how cinobufagin, a traditional Chinese medicine, enhances CDDP-induced cytotoxicity in OS cells. OS 143B cells were treated with cinobufagin and CDDP alone or in combination...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156682/pharmacologic-inhibition-of-pi3k-p110%C3%AE-in-mutant-shp2e76k-expressing-mice
#2
Lisa Deng, Elizabeth L Virts, Reuben Kapur, Rebecca J Chan
Juvenile myelomonocytic leukemia is a childhood malignancy that lacks effective chemotherapies and thus has poor patient outcomes. PI3K p110δ has been found to promote hyperproliferation of cells expressing mutant Shp2. In this study, we tested the efficacy of a PI3Kδ inhibitor in mice expressing the Shp2 gain-of-function mutation, E76K. We found that in vivo treatment of mice led to significantly decreased splenomegaly, reduced frequency of bone marrow progenitor cells, and increased terminally differentiated peripheral blood myeloid cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156357/generation-of-complement-molecular-complex-c5b-9-c5b-9-in-response-to-poly-traumatic-hemorrhagic-shock-and-evaluation-of-c5-cleavage-inhibitors-in-non-human-primates
#3
R Madelaine Paredes, Sarah Reyna, Philip Vernon, Douglas K Tadaki, Jurandir J Dallelucca, Forest Sheppard
Severe trauma initiates a systemic inflammatory cascade and that involves early activation of complement and cleavage of C5 into C5a (anaphylatoxin) and C5b (C5b-9 membrane attack complex). We examined activation of C5 in non-human primate (NHP) models of hemorrhagic shock. Blood plasma concentrations of C5b-9 were significantly increased in NHPs in response to hemorrhage alone and were further increased with the addition of tissue trauma. The onset of increased C5 cleavage was accelerated in NHPs that experienced decompensated poly-traumatic hemorrhagic shock...
November 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29156148/cm-101-type-i-collagen-targeted-mr-imaging-probe-for-detection-of-liver-fibrosis
#4
Christian T Farrar, Eric M Gale, Richard Kennan, Ian Ramsay, Ricard Masia, Gunisha Arora, Kailyn Looby, Lan Wei, Jayashree Kalpathy-Cramer, Michelle M Bunzel, Chunlian Zhang, Yonghua Zhu, Taro E Akiyama, Michael Klimas, Shirly Pinto, Himashinie Diyabalanage, Kenneth K Tanabe, Valerie Humblet, Bryan C Fuchs, Peter Caravan
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, and to assess its ability to help quantify liver fibrosis in animal models. Materials and Methods Biodistribution, pharmacokinetics, and stability of CM-101 in rats were measured with mass spectrometry. Bile duct-ligated (BDL) and sham-treated rats were imaged 19 days after the procedure by using a 1.5-T clinical MR imaging unit. Mice were treated with carbon tetrachloride (CCl4) or with vehicle two times a week for 10 weeks and were imaged with a 7...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29155989/5-hydroxytryptamine-independent-antidepressant-actions-of-r-ketamine-in-a-chronic-social-defeat-stress-model
#5
Kai Zhang, Chao Dong, Yuko Fujita, Atsuhiro Fujita, Kenji Hashimoto
Background: Previous reports suggest that 5-hydroxytryptamine (5-HT) might play a role in the antidepressant actions of (R,S)-ketamine. However, its role in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, is unknown. This study was conducted to examine whether 5-HT depletion affects the antidepressant actions of (R)-ketamine in a chronic social defeat stress (CSDS) model. Methods: An inhibitor of 5-HT synthesis, para-chlorophenylalanine methyl ester hydrochloride (PCPA; 300 mg/kg, twice daily for 3 consecutive days), or vehicle was administered to control and CSDS susceptible mice...
November 16, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29155506/how-desirable-and-undesirable-features-of-na%C3%A3-ve-or-genetically-reengineered-mesenchymal-stem-cells-are-being-considered-in-preclinical-or-clinical-assays
#6
Carlos González-Villarreal, Herminia Guadalupe Martínez-Rodríguez, Salvador Said-Fernández
The implantation of adult mesenchymal stem cells (MSCs) has become a promising alternative in cancer treatments. Accordingly, in this article we revised the ultimate advances in the knowledge on the MSC-homing mechanism, the cancer cell and MSCs interactions and the microvesicles and exosomes used by malignant cells to transport and deliver pro-cancer cytokines or microRNA (miRNA), or by MSCs to favor or fight cancer progression. In addition, we analyzed the current knowledge generated by ongoing or terminated preclinical and clinical trials, using naive MSCs as natural anti-cancer living factors or gene-engineered MSCs as cytokine delivering vehicles, where anti-cancer cytokines were chosen and the pro-cancer factors were avoided...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29155471/alcohol-related-harm-in-emergency-departments-a-prospective-multicentre-study
#7
Assoc Prof Diana Egerton-Warburton, Andrew Gosbell, Katie Moore, Angela Wadsworth, Drew Richardson, Daniel M Fatovich
BACKGROUND: Emergency department alcohol-related presentation data are not routinely collected. It is likely that previous research has underestimated the numbers of patients presenting with alcohol-related conditions. DESIGN: Multicentre, prospective study. Patients were prospectively screened for alcohol-related presentations over a seven-day period in December 2014. Part one involved screening to determine alcohol positive ED presentations, and data collection of patient demographic and clinical information...
November 20, 2017: Addiction
https://www.readbyqxmd.com/read/29155324/angiotensin-receptor-blocker-irbesartan-reduces-stress-induced-intestinal-inflammation-via-at1a-signaling-and-ace2-dependent-mechanism-in-mice
#8
Maimaiti Yisireyili, Yasuhiro Uchida, Koji Yamamoto, Takayuki Nakayama, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toyoaki Murohara, Kyosuke Takeshita
Stress is associated with pathophysiology of both irritable bowel syndrome (IBS) and hypertension. Angiotensin receptor blockers (ARB) have anti-inflammatory properties via inhibition of angiotensin II (Ang II)/Ang II type I receptor axis (AT1). Inhibition of the classical RAS pathway is also involved in upregulation of angiotensin converting enzyme-2 (ACE2), which activates the Ang-(1-7) /Mas pathway to counteract inflammatory signaling and acts as a partner of the amino acid transporter, B(0)AT-1, to absorb tryptophan for regulation of microbiota-gut-brain axis...
November 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29155272/oral-immunization-with-recombinant-lactobacillus-casei-expressing-ompai-confers-protection-against-aeromonas-veronii-challenge-in-common-carp-cyprinus-carpio
#9
Dong-Xing Zhang, Yuan-Huan Kang, Long Chen, Shahrood Ahmed Siddiqui, Chun-Feng Wang, Ai-Dong Qian, Xiao-Feng Shan
Aeromonas veronii is a gram-negative pathogen capable of infecting both fish and mammals, including humans, and natural infection in fish results in irreparable damage to the aquaculture industry. Lactic acid bacteria (LAB) have a number of properties that make them attractive candidates as delivery vehicles for presentation to the mucosa sites of compounds with pharmaceutical interest, in particular vaccines. In this study, we generated two recombinant Lactobacillus casei (surface-displayed or secretory) expressing the OmpAI of A...
November 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29155178/induction-of-immune-related-gene-expression-by-seminal-exosomes-in-the-porcine-endometrium
#10
Rulan Bai, Zeinab Latifi, Kazuya Kusama, Keigo Nakamura, Masayuki Shimada, Kazuhiko Imakawa
Seminal plasma (SP) is considered as a vehicle to carry sperm into female reproductive tract, of which functions have not been completely understood. This study aimed to identify the function of seminal exosomes on porcine endometrium. Exosomes were isolated from the sperm-rich fraction of boar semen and were confirmed by the expression of exosome marker HSP70 and size distribution using nano-sight tracking analysis. Porcine endometrial epithelial cells (EECs) were then treated with seminal exosomes, and RNA extracted were subjected to global expression analysis...
November 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29155077/subchronic-oral-toxicity-study-of-korean-red-ginseng-extract-in-sprague-dawley-rats-with-a-4-week-recovery-period
#11
Sang-Jin Park, JeongHo Noh, Eun Ju Jeong, Yong-Soon Kim, Byung-Cheol Han, Seung-Ho Lee, Kyoung-Sik Moon
Ginseng is a major herbal remedy used in Asian countries for thousands of years and known to restore and enhance vital energy. Korean red ginseng, which is processed by steaming and drying fresh Panax ginseng, is most popular and contains unique ginsenosides, which have anticancer and anti-inflammatory properties. The present study was carried out to evaluate the repeated oral dose toxicity of Korean red ginseng extract. The test article was administered orally once a day to male and female Sprague-Dawley rats at dose levels of 0, 500, 1000, or 2000 mg/kg/day for 13 consecutive weeks (15 animals/sex/group in the vehicle control and 2000 mg/kg/day groups, and 10 animals/sex/group in the 500 and 1000 mg/kg/day groups)...
November 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29154961/inhibition-of-cyclooxygenase-cox-2-suppresses-the-recruitment-of-endothelial-progenitor-cells-in-the-microvasculature-of-endometriotic-lesions
#12
Jeannette Rudzitis-Auth, Ruth M Nickels, Michael D Menger, Matthias W Laschke
The incorporation of endothelial progenitor cells (EPCs) into newly developing blood vessels contributes to the vascularization of endometriotic lesions. here, we analyzed whether cyclooxygenase (COX)-2 signaling regulates this vasculogenic process. Endometriotic lesions were surgically induced in irradiated FVB/N mice, which were reconstituted with bone marrow from FVB/N-TgN (Tie2/green fluorescent protein (GFP)) 287 Sato mice. The animals received β-estradiol 17-valerate once a week and were daily treated with the selective COX-2 inhibitor parecoxib (25 mg/kg) or vehicle (control) over 7 and 28 days...
November 15, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29154916/acute-intravenous-exposure-to-silver-nanoparticles-during-pregnancy-induces-particle-size-and-vehicle-dependent-changes-in-vascular-tissue-contractility-in-sprague-dawley-rats
#13
A K Vidanapathirana, L C Thompson, M Herco, J Odom, S J Sumner, T R Fennell, J M Brown, C J Wingard
The use of silver nanoparticles (AgNP) raises safety concerns during susceptible life stages such as pregnancy. We hypothesized that acute intravenous exposure to AgNP during late stages of pregnancy will increase vascular tissue contractility, potentially contributing to alterations in fetal growth. Sprague Dawley rats were exposed to a single dose of PVP or Citrate stabilized 20 or 110nm AgNP (700μg/kg). Differential vascular responses and EC50 values were observed in myographic studies in uterine, mesenteric arteries and thoracic aortic segments, 24hours post-exposure...
November 14, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29154646/developmental-stability-in-gender-typed-preferences-between-infancy-and-preschool-age
#14
Jillian E Lauer, Sibel D Ilksoy, Stella F Lourenco
Infants exhibit visual preferences for gender-typed objects (e.g., dolls, toy vehicles) that parallel the gender-typed play preferences of preschool-aged children, but the developmental stability of individual differences in early emerging gender-typed preferences has not yet been characterized. In the present study, we examined the longitudinal association between infants' (N = 51) performance on an object-preference task, administered between 6 and 13 months of age, and their play preferences at 4 years of age...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29154530/atg101-single-stranded-antisense-rna-loaded-triangular-dna-nanoparticles-control-human-pulmonary-endothelial-growth-via-regulation-of-cell-macroautophagy
#15
Juan Du, Zhi Xu, Qian Liu, Yu Yang, Hang Qian, Mingdong Hu, Ye Fan, Qi Li, Wei Yao, Hongli Li, Guisheng Qian, Binfeng He, Deshan Zhou, Chengde Mao, Guansong Wang
Autophagy plays a key role in pulmonary vascular remodeling (PVR) via regulation of apoptosis and hyperproliferation of pulmonary arterial endothelial cells (PAECs), which are the subject of increased attention. ATG101 is an essential gene for the initiation of autophagy. While the structure of ATG101 has been well characterized, its exact biological function in autophagy is still unknown. In this study, an ATG101 single-stranded antisense RNA-loaded DNA triangular nanoparticle (ssATG101-TNP) is constructed to knock down ATG101 gene expression...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29154119/a-conceptual-study-on-the-formulation-of-a-permeable-reactive-pavement-with-activated-carbon-additives-for-controlling-the-fate-of-non-point-source-environmental-organic-contaminants
#16
Shengyi Huang, Chenju Liang
To take advantage of the road pavement network where non-point source (NPS) pollution such as benzene, toluene, ethyl-benzene, and xylene (BTEX) from vehicle traffic exhaust via wet and dry atmospheric deposition occurs, the asphalt pavement may be used as a media to control the NPS pollution. An experiment to prepare an adsorptive porous reactive pavement (PRP) was initiated to explore the potential to reduce environmental NPS vehicle pollution. The PRP was prepared and studied as follows: various activated carbons (AC) were initially screened to determine if they were suitable as an additive in the porous asphalt mixture; various mixtures of a selected AC were incorporated with the design of porous asphalt concrete (PAC) to produce PRP, and the PRP formulations were tested to ensure that they comply with the required specifications; qualified specimens were subsequently tested to determine their adsorption capacity for BTEX in aqueous solution, as compared to conventional PAC...
November 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29154012/quantification-of-flood-risk-mitigation-benefits-a-building-scale-damage-assessment-through-the-rasor-platform
#17
Chiara Arrighi, Lauro Rossi, Eva Trasforini, Roberto Rudari, Luca Ferraris, Marcello Brugioni, Serena Franceschini, Fabio Castelli
Flood risk mitigation usually requires a significant investment of public resources and cost-effectiveness should be ensured. The assessment of the benefits of hydraulic works requires the quantification of (i) flood risk in absence of measures, (ii) risk in presence of mitigation works, (iii) investments to achieve acceptable residual risk. In this work a building-scale is adopted to estimate direct tangible flood losses to several building classes (e.g. residential, industrial, commercial, etc.) and respective contents, exploiting various sources of public open data in a GIS environment...
November 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29153779/lambda-display-phage-as-a-mucosal-vaccine-delivery-vehicle-for-peptide-antigens
#18
Patricia González Cano, Lakshman N A Gamage, Kristen Marciniuk, Connie Hayes, Scott Napper, Sidney Hayes, Philip J Griebel
Bacteriophage are structurally stable in the gastro-intestinal tract and have favorable traits of safety, stability, ease of production, and immunogenicity. These attributes make them potential candidates as oral vaccine delivery vehicles but little is known about their capacity to induce mucosal immune responses in the small intestine. Whole body imaging of mice confirmed lambda bacteriophage (LP) were distributed throughout the gastro-intestinal tract 24 h after oral delivery. In newborn calves, targeted delivery of LP within the small intestine confirmed LP were immunogenic in a dose-dependent manner and were taken up by Peyer's patches...
November 16, 2017: Vaccine
https://www.readbyqxmd.com/read/29153449/the-changing-epidemiology-of-open-fractures-in-vehicle-occupants-pedestrians-motorcyclists-and-cyclists
#19
Dennis Winkler, Stuart T Goudie, Charles M Court-Brown
AIMS: To investigate the changing epidemiology of open fractures in vehicle occupants, pedestrians, motorcyclists and cyclists. MATERIALS AND METHODS: Data on all non-spinal open fractures admitted to the Royal Infirmary of Edinburgh after a road traffic accident between 1988 and 2010 were collected and analysed to provide information about the changing epidemiology in different patient groups. Demographic information was collected on all patients with the severity of injury being analysed with the Injury Severity Score (ISS), Musculoskeletal Index (MSI) and the number of open fractures...
November 14, 2017: Injury
https://www.readbyqxmd.com/read/29153032/evaluation-of-the-carcinogenic-potential-of-roxadustat-fg-4592-a-small-molecule-inhibitor-of-hypoxia-inducible-factor-prolyl-hydroxylase-in-cd-1-mice-and-sprague-dawley-rats
#20
James Beck, Carroll Henschel, James Chou, Al Lin, Ughetta Del Balzo
The carcinogenic potential of roxadustat (FG-4592), a novel orally active, heterocyclic small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) enzymes in clinical development for treatment of anemia, was evaluated in CD-1 mice and Sprague Dawley rats. Inhibition of HIF-PH by roxadustat leads to a rapid increase in cytoplasmic HIF-α concentrations, followed by translocation of HIF-α to the nucleus and upregulation of HIF-responsive genes, including erythropoietin. Roxadustat was dosed by oral gavage 3 times weekly (TIW) for up to 104 weeks in mice at 0, 15, 30, and 60 mg/kg and in rats at 0, 2...
January 1, 2017: International Journal of Toxicology
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