keyword
MENU ▼
Read by QxMD icon Read
search

resistant itp

keyword
https://www.readbyqxmd.com/read/27876239/case-reports-of-idiopathic-thrombocytopenia-unresponsive-to-first-line-therapies-treated-with-traditional-herbal-medicines-based-on-syndrome-differentiation
#1
Juno Yang, Beom-Joon Lee, Jun-Hwan Lee
The objective of our study is to present two cases showing the effects of traditional Korean herbal medicines based on traditional Korean medicine (TKM) for the treatment of immune thrombocytopenic purpura (ITP). One patient showed no response to treatment with steroids and an immunosuppressive agent. Moreover, liver toxicity and side effects of steroids were evident. However, after he ceased conventional treatment and started to take an herbal medicine, his liver function normalized and the steroid side effects resolved...
October 21, 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/27766635/procoagulant-profile-in-patients-with-immune-thrombocytopenia
#2
María T Álvarez-Román, Ihosvany Fernández-Bello, Víctor Jiménez-Yuste, Mónica Martín-Salces, Elena G Arias-Salgado, María I Rivas Pollmar, Raúl Justo Sanz, Nora V Butta
Despite their low platelet count some immune thrombocytopenia (ITP) patients seldom bleed, indicating the presence of factors to compensate thrombocytopenia. Moreover, ITP patients may have an increased risk for thrombosis. These facts suggest the presence of procoagulant mechanisms that have not been clarified yet. The aim of this study was to identify these possible factors. Moreover, the utility of rotational thromboelastometry (ROTEM(®) ) to test haemostasis in these patients was also evaluated. Patients with ITP presented a procoagulant profile due to an increased amount of platelet- and red cell-microparticles, an increased resistance to protein C and the formation of a clot more resistant to fibrinolysis due to augmented levels of plasminogen activator inhibitor-1, which might reflect an endothelial damage/activation in ITP patients...
December 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27377010/worsening-hypoxemia-in-the-face-of-increasing-peep-a-case-of-large-pulmonary-embolism-in-the-setting-of-intracardiac-shunt
#3
Glen T Granati, Getu Teressa
BACKGROUND Patent foramen ovale (PFO) are common, normally resulting in a left-to-right shunt or no net shunting. Pulmonary embolism (PE) can cause sustained increased pulmonary vascular resistance (PVR) and right atrial pressure. Increasing positive end-expiratory pressure (PEEP) improves oxygenation at the expense of increasing intrathoracic pressures (ITP). Airway pressure release ventilation (APRV) decreases shunt fraction, improves ventilation/perfusion (V/Q) matching, increases cardiac output, and decreases right atrial pressure by facilitating low airway pressure...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27313917/nocardia-transvalensis-disseminated-infection-in-an-immunocompromised-patient-with-idiopathic-thrombocytopenic-purpura
#4
Jorge García-Méndez, Erika M Carrillo-Casas, Andrea Rangel-Cordero, Margarita Leyva-Leyva, Juan Xicohtencatl-Cortes, Roberto Arenas, Rigoberto Hernández-Castro
Nocardia transvalensis complex includes a wide range of microorganisms with specific antimicrobial resistance patterns. N. transvalensis is an unusual Nocardia species. However, it must be differentiated due to its natural resistance to aminoglycosides while other Nocardia species are susceptible. The present report describes a Nocardia species involved in an uncommon clinical case of a patient with idiopathic thrombocytopenic purpura and pulmonary nocardiosis. Microbiological and molecular techniques based on the sequencing of the 16S rRNA gene allowed diagnosis of Nocardia transvalensis sensu stricto...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27281793/thrombopoietin-receptor-agonists-shift-the-balance-of-fc%C3%AE-receptors-toward-inhibitory-receptor-iib-on-monocytes-in-itp
#5
Xin-Guang Liu, Shuang Liu, Qi Feng, Xue-Na Liu, Guo-Sheng Li, Zi Sheng, Peng Chen, Yang Liu, Yu Wei, Xiao-Yuan Dong, Ping Qin, Chengjiang Gao, Chunhong Ma, Lei Zhang, Ming Hou, Jun Peng
Elevated expression of the activating Fcγ receptor (FcγR) I and FcγRIIa together with decreased expression of the inhibitory FcγRIIb are involved in the pathogenesis of primary immune thrombocytopenia (ITP). Thrombopoietin receptor agonists (TPO-RAs) have been used clinically for the management of ITP; however, little is known about the effect of TPO-RAs on FcγR modulation in ITP. In this prospective study, we measured the alteration in monocyte FcγR expression from 21 corticosteroid-resistant/relapsed patients with chronic ITP receiving eltrombopag therapy...
August 11, 2016: Blood
https://www.readbyqxmd.com/read/27258931/effects-of-the-multidrug-resistance-1-gene-on-drug-resistance-in-primary-immune-thrombocytopenia
#6
Wenjie Liu, Huiyuan Li, Donglei Zhang, Mingen Lv, Yang Li, Yating Hao, Yunfei Chen, Xiaofan Liu, Feng Xue, Lei Zhang, Renchi Yang
Primary immune thrombocytopenia (ITP) is an autoimmune disorder that is characterized by low platelet count. Glucocorticoids (GCs) resistance is a great challenge in the treatment of ITP. P-glycoprotein (P-gp) is a widely studied protein, which is associated with drug resistance. However, in ITP, the functional activity and immune regulation mechanism of P-gp remain uncertain. In this study, we evaluated the expression and functional activity of P-gp in different lymphocyte subsets, explored the correlation between P-gp function and GCs resistance and investigated the role of P-gp in ITP pathogenesis...
June 3, 2016: Autoimmunity
https://www.readbyqxmd.com/read/27158433/life-threatening-autoimmune-hemolytic-anemia-and-idhiopatic-thrombocytopenic-purpura-successful-selective-splenic-artery-embolization
#7
Matteo Molica, Fulvio Massaro, Giorgia Annechini, Erminia Baldacci, Gianna Maria D'Elia, Riccardo Rosati, Silvia Maria Trisolini, Paola Volpicelli, Robin Foà, Saveria Capria
Selective splenic artery embolization (SSAE) is a nonsurgical intervention characterized by the transcatheter occlusion of the splenic artery and/or its branch vessels using metallic coils or other embolic devices. It has been applied for the management of splenic trauma, hypersplenism with portal hypertension, hereditary spherocytosis, thalassemia and splenic hemangioma. We hereby describe a case of a patient affected by idiopathic thrombocytopenic purpura (ITP) and warm auto-immune hemolytic anemia (AIHA) both resistant to immunosuppressive and biological therapies, not eligible for a surgical intervention because of her critical conditions...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27077774/relationship-between-expression-of-glucocorticoid-receptor-isoforms-and-glucocorticoid-resistance-in-immune-thrombocytopenia
#8
Yan Liang, Meng Meng Song, Shi Yan Liu, Liang Liang Ma
BACKGROUND: Glucocorticoids (GCs) play an important role in the treatment of several hematological malignancies, such as immune thrombocytopenia (ITP). The glucocorticoid receptor (GR) mediates the effects of GCs. Five isoforms of GR mRNA were described: GRα, GRβ, GRγ, GRP, and GRA. GR levels are regulated by alternative splicing of GR mRNA. Several studies demonstrated that a lower GR expression was associated with poor GC response. PURPOSE: This study investigated the expression of GR isoforms and the relationship between GC resistance in ITP...
August 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/26740892/seasonal-association-of-immune-thrombocytopenia-in-adults
#9
Anıl Tombak, Burcu Boztepe, Naci Tiftik, Melda Cömert, Ozan Salim, Kaniye Aydın, Emel Gürkan, Orhan Kemal Yücel, Güray Saydam, Mehmet Ali Sungur
BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune disorder. It is characterized by thrombocytopenia due to thrombocyte destruction mediated by autoantibodies; however, cytotoxic and defective regulatory T-lymphocytes play an important role in its pathogenesis. While childhood ITP is usually acute, self-limiting and generally seasonal in nature, ITP in adults is usually chronic; its relation with seasons has not been studied. AIMS: We investigated whether months and/or seasons have triggering roles in adults with ITP...
October 2015: Balkan Medical Journal
https://www.readbyqxmd.com/read/26492283/b-cell-hyperfunction-in-children-with-immune-thrombocytopenic-purpura-persists-after-splenectomy
#10
Paola Giordano, Simona Cascioli, Giuseppe Lassandro, Valentina Marcellini, Fabio Cardinale, Federica Valente, Franco Locatelli, Rita Carsetti
BACKGROUND: Immune thrombocytopenic purpura (ITP) is characterized by reduced platelet count secondary to immune-mediated destruction, this results in an increased bleeding risk. Autoantibodies binding to platelets tag them for premature destruction in the spleen. For this reason, splenectomy is often performed as treatment of chronic forms of disease that are resistant to pharmacological therapy. METHODS: We studied 30 patients with ITP and compared them with age-matched controls...
February 2016: Pediatric Research
https://www.readbyqxmd.com/read/26491414/new-diagnostic-strategies-for-detection-of-helicobacter-pylori-infection-in-pediatric-patients
#11
Benjamin D Gold, Mark A Gilger, Steven J Czinn
Helicobacter pylori (H pylori) is a common chronic bacterial infection that is an important cause of peptic ulcer disease and gastroduodenal disease in children. H pylori is also associated with extragastric manifestations, including growth reduction, iron-deficiency anemia, and idiopathic thrombocytopenic purpura. Current guidelines recommend endoscopy with biopsy for the definitive demonstration of H pylori infection. In contrast to serology, the fecal antigen test and the urea breath test provide reliable, sensitive, and specific results for detecting active H pylori infection in children before and after treatment...
December 2014: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26372824/extragastric-diseases-and-helicobacter-pylori
#12
Francesco Franceschi, Antonio Gasbarrini, Stergios A Polyzos, Jannis Kountouras
The extragastric manifestations of Helicobacter pylori infection still remain a very strong topic throughout the H. pylori world. Indeed, H. pylori may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. While its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that H. pylori may increase the risk of acute coronary syndrome, contribute to insulin resistance and be associated with neurodegenerative, respiratory, and other miscellaneous disorders previously associated with other conditions...
September 2015: Helicobacter
https://www.readbyqxmd.com/read/26314452/-effect-of-decitabine-on-megakaryocyte-culture-of-steroid-resistant-itp-patients
#13
You-Ping Liao, Yu-Xia Liu, Qing-Zhao Li, Guo-Yu Hu
OBJECTIVE: To investigate the effect of decitabine and plasma of ITP patients on in vitro cultrue of megakaryocytes in bone marrow of steroid-resistant ITP patients. METHODS: Bone marrow mononuclear cells were isolated from 20 steroid-resistant ITP patients, both methyl cellulose semisolid culture system (to observe and count the number of megakaryocytes colony-forming unit) and liquid culture system (to analysis the expression rate of CD41a(+) cells) were used for megakaryocyte cultrue...
August 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26242673/role-of-splenectomy-for-immune-thrombocytopenic-purpura-itp-in-the-era-of-new-second-line-therapies-and-in-the-setting-of-a-high-prevalence-of-hiv-associated-itp
#14
Katherine Rae Antel, Eugenio Panieri, Nicolas Novitzky
BACKGROUND: New agents are being used as second-line treatment for immune thrombocytopenia (ITP) and have brought into question the relevance of splenectomy for steroid-resistant ITP. METHODS: We retrospectively analysed 73 patients who underwent splenectomy for ITP at our institution over an 11-year period. The median follow-up period was 25 months; patients with follow-up of <1 month were excluded. The outcomes of splenectomy were compared in HIV-positive v...
May 2015: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/26101140/capillary-electrophoresis-for-fast-detection-of-heterogeneous-population-in-colistin-resistant-gram-negative-bacteria
#15
Guillaume Sautrey, Raphaël E Duval, Alicia Chevalley, Stéphane Fontanay, Igor Clarot
It has been shown that diverse strains of bacteria can be separated according to their characteristic surface properties by means of CE. We employed here this analytical technique to the study of colistin-resistance in Gram-negative bacteria, which involves the selection of mutants with modified outer membrane composition resulting in changes of surface cell properties. In the same way as with molecular entities, we performed firstly the validation of an ITP-based CE method for three common pathogenic Gram-negative bacteria namely Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae...
October 2015: Electrophoresis
https://www.readbyqxmd.com/read/26076780/single-nucleotide-polymorphisms-of-the-inflamatory-cytokine-genes-interleukin-1b-tumor-necrosis-factors-a-and-tumor-necrosis-factor-b-in-adult-patients-with-immune-thrombocytopenia
#16
M Pavkovic, R Angelovic, M Popova-Simjanovska, O Karanfilski, S Trpkovska-Terzieva, T Sotirova, L Cevreska, A Stojanovic
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia due to platelet autoantibodies, causing an accelerated clearance of opsonized platelets by phagocytes. The etiology of ITP remains unclear, both genetic and environmental factors may have a role in the disease development. The aim of our study was to investigate a possible association of three single nucleotide polymorphisms (SNP) in the genes for interleukin beta (IL1B-511C/T), tumor necrosis factor beta (TNF+252G/A) and tumor necrosis factor alpha (TNFA-308G/A) with ITP...
2015: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/25976731/vincristine-efficacy-and-safety-in-treating-immune-thrombocytopenia-a-retrospective-study-of-35-patients
#17
Jérôme Stirnemann, Najett Kaddouri, Medhi Khellaf, Anne-Sophie Morin, Virginie Prendki, Marc Michel, Arsène Mekinian, Philippe Bierling, Pierre Fenaux, Bertrand Godeau, Olivier Fain
Although vincristine (VCR) is sometimes prescribed for newly diagnosed immune thrombocytopenia (ITP), its efficacy in refractory ITP and sustained efficacy has yet to be demonstrated. We describe our clinical experience and recommend vincristine's correct place in ITP management. This retrospective study analysed data from 35 patients with newly diagnosed (ND), persistent (P) or chronic (C) ITP treated with VCR. The initial response rate, defined as >30 × 10(9) platelets/L, reached 86% after a median of 7 [interquartile range (IQR) 6-13] days...
March 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/25914025/eltrombopag-for-the-treatment-of-immune-thrombocytopenia-the-aegean-region-of-turkey-experience
#18
Füsun Özdemirkıran, Bahriye Payzın, H Demet Kiper, Sibel Kabukçu, Gülsüm Akgün Çağlıyan, Selda Kahraman, Ömür Gökmen Sevindik, Cengiz Ceylan, Gürhan Kadıköylü, Fahri Şahin, Ali Keskin, Öykü Arslan, Mehmet Ali Özcan, Gülnur Kabukçu, Gülsüm Görgün, Zahit Bolaman, Filiz Büyükkeçeci, Oktay Bilgir, İnci Alacacıoğlu, Filiz Vural, Murat Tombuloğlu, Zafer Gökgöz, Güray Saydam
OBJECTIVE: Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease of the platelet count to less than 100x109/L. Although it is included in a benign disease group, bleeding complications may be mortal. With a better understanding of the pathophysiology of the disease, thrombopoietin receptor agonists, which came into use in recent years, seem to be an effective option in the treatment of resistant cases. This study aimed to retrospectively assess the efficacy, long-term safety, and tolerability of eltrombopag in Turkish patients with chronic ITP in the Aegean region of Turkey...
December 2015: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/25801336/nucleotide-triphosphate-promiscuity-in-mycobacterium-tuberculosis-dethiobiotin-synthetase
#19
Wanisa Salaemae, Min Y Yap, Kate L Wegener, Grant W Booker, Matthew C J Wilce, Steven W Polyak
Dethiobiotin synthetase (DTBS) plays a crucial role in biotin biosynthesis in microorganisms, fungi, and plants. Due to its importance in bacterial pathogenesis, and the absence of a human homologue, DTBS is a promising target for the development of new antibacterials desperately needed to combat antibiotic resistance. Here we report the first X-ray structure of DTBS from Mycobacterium tuberculosis (MtDTBS) bound to a nucleotide triphosphate (CTP). The nucleoside base is stabilized in its pocket through hydrogen-bonding interactions with the protein backbone, rather than amino acid side chains...
May 2015: Tuberculosis
https://www.readbyqxmd.com/read/25792670/a-study-of-human-killer-cell-immunoglobulin-like-receptor-and-multidrug-resistance-gene-polymorphisms-in-children-with-immune-thrombocytopenia
#20
Nagham Mohamed Samy El-Beblawy, Nancy Samir Elbarbary, Tarek Mostafa Kamal, Perehan Mohsen Mahmoud
THE OBJECTIVE: This study was undertaken to detect characterization of the different gene polymorphisms in Human killer cell immunoglobulin-like receptor (KIR2) gene and multi-drug resistance (MDR1) gene, among childhood ITP Egyptian patients. In addition to assess the potential role of these polymorphisms in relation to types of ITP and response to different treatment modalities. PATIENTS AND METHODS: A total of 48 pediatric patients with immune thrombocytopenia (ITP; 24 newly diagnosed and 24 chronic) and 35 healthy controls were investigated via polymerase chain reaction-restriction fragment length polymorphism analysis for multidrug resistance (MDR) 1 and killer cell immunoglobulin-like receptor (KIR) 2 genes...
July 2016: Clinical and Applied Thrombosis/hemostasis
keyword
keyword
117360
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"