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https://www.readbyqxmd.com/read/28799956/peripheral-blunt-dissection-using-a-microhoe-facilitated-method-for-descemet-membrane-endothelial-keratoplasty-donor-tissue-preparation
#1
Armand M Borovik, Mauricio Perez, Tova Lifshitz, Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Mahmood Showail, Amir Rosenblatt, David S Rootman
PURPOSE: To describe a modified technique for Descemet membrane donor tissue preparation that facilitates the original Melles stripping technique. METHODS: Descemet membrane is prepared using a Rootman/Goldich modified Sloane microhoe, using a blunt instrument as opposed to a sharp blade or needle and begins dissection within the trabecular meshwork. The trabecular tissue is dissected for 360 degrees, and then Descemet membrane is stripped to approximately 50%. A skin biopsy punch is then used to create fenestration in the cornea, which is used to mark an "F...
August 9, 2017: Cornea
https://www.readbyqxmd.com/read/28758045/linear-time-algorithms-to-restrict-insider-access-using-multi-policy-access-control-systems
#2
Peter Mell, James Shook, Richard Harang, Serban Gavrila
An important way to limit malicious insiders from distributing sensitive information is to as tightly as possible limit their access to information. This has always been the goal of access control mechanisms, but individual approaches have been shown to be inadequate. Ensemble approaches of multiple methods instantiated simultaneously have been shown to more tightly restrict access, but approaches to do so have had limited scalability (resulting in exponential calculations in some cases). In this work, we take the Next Generation Access Control (NGAC) approach standardized by the American National Standards Institute (ANSI) and demonstrate its scalability...
March 2017: J Wirel Mob Netw Ubiquitous Comput Dependable Appl
https://www.readbyqxmd.com/read/28747165/increased-ercc1-expression-is-linked-to-chromosomal-aberrations-and-adverse-tumor-biology-in-prostate-cancer
#3
Frank Jacobsen, Billurvan Taskin, Nathaniel Melling, Charlotte Sauer, Corinna Wittmer, Claudia Hube-Magg, Martina Kluth, Ronald Simon, Dirk Pehrke, Burkhard Beyer, Thomas Steuber, Imke Thederan, Guido Sauter, Thorsten Schlomm, Waldemar Wilczak, Katharina Möller, Sören A Weidemann, Susanne Burdak-Rothkamm
BACKGROUND: Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression. METHODS: To better understand the impact of ERCC1 protein expression in human prostate cancer, a preexisting tissue microarray (TMA) containing more than 12,000 prostate cancer specimens was analyzed by immunohistochemistry and data were compared with tumor phenotype, PSA recurrence and several of the most common genomic alterations (TMPRSS2:ERG fusions: deletions of PTEN, 6q, 5q, 3p)...
July 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28746138/faculty-resident-co-learning-a-longitudinal-exploration-of-an-innovative-model-for-faculty-development-in-quality-improvement
#4
Brian M Wong, Joanne Goldman, Jeannette M Goguen, Christian Base, Leahora Rotteau, Elaine Van Melle, Ayelet Kuper, Kaveh G Shojania
PURPOSE: To examine the effectiveness of co-learning, wherein faculty and trainees learn together, as a novel approach for building quality improvement (QI) faculty capacity. METHOD: From July 2012 through September 2015, the authors conducted 30 semistructured interviews with 23 faculty participants from the Co-Learning QI Curriculum of the Department of Medicine, Faculty of Medicine, University of Toronto, and collected descriptive data on faculty participation and resident evaluations of teaching effectiveness...
August 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28735883/permeability-modes-in-fluctuating-lipid-membranes-with-dna-translocating-pores
#5
REVIEW
L H Moleiro, M Mell, R Bocanegra, I López-Montero, P Fouquet, Th Hellweg, J L Carrascosa, F Monroy
Membrane pores can significantly alter not only the permeation dynamics of biological membranes but also their elasticity. Large membrane pores able to transport macromolecular contents represent an interesting model to test theoretical predictions that assign active-like (non-equilibrium) behavior to the permeability contributions to the enhanced membrane fluctuations existing in permeable membranes [Maneville et al. Phys. Rev. Lett. 82, 4356 (1999)]. Such high-amplitude active contributions arise from the forced transport of solvent and solutes through the open pores, which becomes even dominant at large permeability...
July 16, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28724118/emergency-medical-services-response-times-in-rural-suburban-and-urban-areas
#6
Howard K Mell, Shannon N Mumma, Brian Hiestand, Brendan G Carr, Tara Holland, Jason Stopyra
No abstract text is available yet for this article.
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28722128/solar-insolation-in-springtime-influences-age-of-onset-of-bipolar-i-disorder
#7
M Bauer, T Glenn, M Alda, M A Aleksandrovich, O A Andreassen, E Angelopoulos, R Ardau, Y Ayhan, C Baethge, S R Bharathram, R Bauer, B T Baune, C Becerra-Palars, F Bellivier, R H Belmaker, M Berk, Y Bersudsky, Ş Bicakci, H Birabwa-Oketcho, T D Bjella, L Bossini, J Cabrera, E Y W Cheung, M Del Zompo, S Dodd, M Donix, B Etain, A Fagiolini, K N Fountoulakis, M A Frye, A Gonzalez-Pinto, J F Gottlieb, P Grof, H Harima, C Henry, E T Isometsä, S Janno, F Kapczinski, M Kardell, S Khaldi, S Kliwicki, B König, T L Kot, R Krogh, M Kunz, B Lafer, M Landén, E R Larsen, U Lewitzka, R W Licht, C Lopez-Jaramillo, G MacQueen, M Manchia, W Marsh, M Martinez-Cengotitabengoa, I Melle, F Meza-Urzúa, M Yee Ming, S Monteith, G Morken, E Mosca, R Munoz, S V Mythri, F Nacef, R K Nadella, F G Nery, R E Nielsen, C O'Donovan, A Omrani, Y Osher, H Østermark Sørensen, U Ouali, Y Pica Ruiz, M Pilhatsch, M Pinna, F D R da Ponte, D Quiroz, R Ramesar, N Rasgon, M S Reddy, A Reif, P Ritter, J K Rybakowski, K Sagduyu, Â M Scippa, E Severus, C Simhandl, D J Stein, S Strejilevich, M Subramaniam, A H Sulaiman, K Suominen, H Tagata, Y Tatebayashi, L Tondo, C Torrent, A E Vaaler, J Veeh, E Vieta, B Viswanath, M Yoldi-Negrete, M Zetin, Y Zgueb, P C Whybrow
OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset...
July 19, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28702349/distinct-multivariate-brain-morphological-patterns-and-their-added-predictive-value-with-cognitive-and-polygenic-risk-scores-in-mental-disorders
#8
Nhat Trung Doan, Tobias Kaufmann, Francesco Bettella, Kjetil Nordbø Jørgensen, Christine Lycke Brandt, Torgeir Moberget, Dag Alnæs, Gwenaëlle Douaud, Eugene Duff, Srdjan Djurovic, Ingrid Melle, Torill Ueland, Ingrid Agartz, Ole A Andreassen, Lars T Westlye
The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is known about the complementary clinical value of brain structural phenotypes when combined with data on cognitive performance and genetic risk. Using data-driven fusion of cortical thickness, surface area, and gray matter density maps (GMD), we found six biologically meaningful patterns showing strong group effects, including four statistically independent multimodal patterns reflecting co-occurring alterations in thickness and GMD in patients, over and above two other independent patterns of widespread thickness and area reduction...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28701275/is-going-into-stable-symptomatic-remission-associated-with-a-more-positive-development-of-life-satisfaction-a-10-year-follow-up-study-of-first-episode-psychosis
#9
Erlend Strand Gardsjord, Kristin Lie Romm, Jan Ivar Røssberg, Svein Friis, Helene Eidsmo Barder, Julie Evensen, Ulrik Haahr, Wenche Ten Velden Hegelstad, Inge Joa, Jan Olav Johannessen, Johannes Langeveld, Tor Ketil Larsen, Stein Opjordsmoen, Bjørn Rishovd Rund, Erik Simonsen, Per Vaglum, Thomas McGlashan, Ingrid Melle
BACKGROUND: Quality of life is an important outcome measure for patients with psychosis. We investigated whether going into stable symptomatic remission is associated with a more positive development of subjective quality of life (S-QoL) and if different patient characteristics are associated with S-QoL depending on remission status. METHODS: Three hundred and one patients with a first-episode psychosis were included at baseline. At 10-year follow-up 186 were reassessed...
July 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28697893/mechanical-valves-in-the-pulmonary-position-an-international-retrospective-analysis
#10
Hanna Pragt, Joost P van Melle, Hoda Javadikasgari, Dong Man Seo, John M Stulak, Igor Knez, Jürgen Hörer, Christian Muñoz-Guijosa, Mahyar G Dehaki, Hong Ju Shin, Joseph A Dearani, Maziar G Dehaki, Petronella G Pieper, Christine Eulenburg, Laura Dos, Tjark Ebels
OBJECTIVE: Life expectancy of patients with congenital heart disease has improved over the past decades, increasing the need for a durable pulmonary prosthetic valve. Biological valves in various forms have become the valve of choice for pulmonary valve replacement (PVR), but structural valve deterioration is unavoidable in the long term. Use of a mechanical valve could be an alternative, but data on long-term outcomes are sparse. METHODS: We retrospectively collected and analyzed data on 364 patients with mechanical valves implanted in the pulmonary position between 1965 and 2014...
May 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28692473/to-bleed-or-not-to-bleed-is-that-the-question
#11
Matthew W Mell, Mary T Hawn
No abstract text is available yet for this article.
July 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28689031/re-defining-the-characteristics-of-environmental-volunteering-creating-a-typology-of-community-scale-green-infrastructure
#12
Gemma Jerome, Ian Mell, Dave Shaw
One way to engage people with green infrastructure (GI) is as environmental volunteers. Previous studies explored the nature of such groups/projects in terms of the benefits they deliver such as their impact on levels of social capital within a pre-defined community. However, existing literature contributes little to our understanding of the composition, characteristics and mechanisms used to form and maintain these groups. As such, it is difficult to establish the influencing factors determining the capacity of a group to sustain its provision over time...
July 6, 2017: Environmental Research
https://www.readbyqxmd.com/read/28686528/the-vaginal-pressure-inducer-a-new-device-to-test-the-un-pleasurableness-and-tolerance-of-vaginal-pressure-and-the-influence-of-sexual-stimuli
#13
Reinhilde J Melles, Marieke D Dewitte, Moniek M Ter Kuile, Charlie Bonnemayer, Madelon M L Peters
To better understand the impact of sexual stimuli on genital pain, a new instrument was developed: the Vaginal Pressure Inducer (VPI). We administered gradually increasing vaginal pressure with the VPI to sexually functional women while watching a neutral, erotic or explicit sex film. Women had higher unpleasantness thresholds in a sexual context compared to a non-sexual context. Moreover, ratings of pleasurableness were higher in the sexual compared to neutral context and most so during the explicit sexual film...
July 7, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28679776/phase-i-trial-of-intravenous-oncolytic-vaccinia-virus-gl-onc1-with-cisplatin-and-radiotherapy-in-patients-with-locoregionally-advanced-head-and-neck-carcinoma
#14
Loren K Mell, Kevin T Brumund, Gregory A Daniels, Sunil J Advani, Kaveh Zakeri, Mary E Wright, Sara-Jane Onyeama, Robert A Weisman, Parag R Sanghvi, Peter J Martin, Aladar A Szalay
Pre-clinical models have shown that the effectiveness of GL-ONC1, a modified <p>oncolytic vaccinia virus, is enhanced by radiation and chemotherapy. The purpose of this study</p> <p>was to determine the safety of GL-ONC1 when delivered intravenously with chemoradiotherapy</p> <p>to patients with primary, non-metastatic head and neck cancer.</p> <p>EXPERIMENTAL DESIGN: Patients with locoregionally advanced unresected, non-metastatic</p> <p>carcinoma of the head/neck, excluding stage III-IVA p16-positive oropharyngeal cancers, were</p> <p>treated with escalating doses and cycles of intravenous GL-ONC1, along with radiotherapy and</p> <p>chemotherapy...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28672072/the-blue-bubble-technique-an-ab-interno-approach-for-descemet-separation-in-deep-anterior-lamellar-keratoplasty-dalk-using-trypan-blue-stained-viscoelastic-device
#15
Eitan Livny, Irit Bahar, Naama Hammel, Yoav Nahum
BACKGROUND: In this study we examined a novel variant of "Big-Bubble" Deep Anterior Lamellar Keratoplasty (DALK) using trypan-blue-stained viscoelastic device for the creation of a pre-Descemetic bubble. METHODS: Ten corneoscleral rims were mounted on an artificial anterior chamber (AC). The anterior chamber was filled with air through a limbal paracentesis. A Melles' triangulated spatula was inserted through the paracentesis, with its tip penetrating the AC, was then slightly retracted and pushed into the deep stroma above the roof of the paracentesis...
July 3, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28645904/intra-articular-lipoma-of-the-hip
#16
Anthony J Mells, G Max Gosey, Michael P Muldoon
Intra-articular lipoma of the hip is a rare entity, with only two reports published in the English-language literature. We present a case of successful arthroscopic resection of an intra-articular peripheral compartment lipoma in a 69-year-old woman with a coincident labral tear. This woman presented with left hip pain that developed gradually over 2 years and increased over 2 months. MRI showed a fat-intense mass in the anterior aspect of the hip joint, convincing for intra-articular lipoma. Physical examination in the operating room reproduced decreased range of motion and evidence of impingement but with a soft endpoint...
June 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28644238/prevention-and-management-of-descemet-membrane-endothelial-keratoplasty-complications
#17
Ruth Quilendrino, Marina Rodriguez-Calvo de Mora, Lamis Baydoun, Lisanne Ham, Korine van Dijk, Isabel Dapena, Silke Oellerich, Gerrit R J Melles
PURPOSE: To describe Descemet membrane endothelial keratoplasty (DMEK) complications and strategies for their prevention and management. METHODS: Five hundred consecutive eyes with DMEK of 393 patients were reviewed in this retrospective study for intraoperative and postoperative complications up to 2 years and for corresponding management. RESULTS: Intraoperative challenges (difficult graft unfolding/positioning, high vitreous pressure, iris root hemorrhage, and Descemet membrane remnants) were encountered in 81 eyes (16...
September 2017: Cornea
https://www.readbyqxmd.com/read/28632478/sexual-risk-behaviors-and-predictors-of-inconsistent-condom-use-among-crack-cocaine-users-in-the-french-overseas-territories-in-the-americas
#18
Marie-Claire Parriault, Astrid Van-Melle, Célia Basurko, Larissa Valmy, Bruno Hoen, André Cabié, Marie-Thérèse Goerger-Sow, Mathieu Nacher
The French overseas territories in the Americas are the French territories most affected by HIV. Crack cocaine users are particularly impacted. The objective of this study was to describe sexual risk behaviors and inconsistent condom use among crack cocaine users. A total of 640 crack cocaine users were interviewed. The sampling method was non-probabilistic. An anonymous standardized questionnaire of 110 questions was used. Over a third of persons did not use condoms systematically with casual sex partners (36...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28624733/gastrointestinal-illness-linked-to-incidents-in-drinking-water-distribution-networks-in-sweden
#19
Melle Säve-Söderbergh, John Bylund, Annika Malm, Magnus Simonsson, Jonas Toljander
During recent years, knowledge gaps on drinking water-related gastrointestinal illness have been identified, especially for non-epidemic cases. Pathogen contamination of drinking water during distribution has been suggested to contribute to these cases, but the risk factors are not yet fully understood. During 2014-2015, we conducted an epidemiological study in five municipalities in Sweden, to assess whether incidents in the drinking water distribution system influence the risk of gastrointestinal illness...
June 5, 2017: Water Research
https://www.readbyqxmd.com/read/28624095/fontan-circulation-over-time
#20
Djoeke Wolff, Joost P van Melle, Beatrijs Bartelds, Floris-Jan S Ridderbos, Graziella Eshuis, Elisabeth B H J van Stratum, Salvador J Recinos, Brigitte W M Willemse, Hans Hillege, Tineke P Willems, Tjark Ebels, Rolf M F Berger
The unique, unphysiological Fontan circulation is associated with an impaired functional status of the patients that is suggested to deteriorate over time. Unfortunately, previous studies did not integrate both pulmonary and cardiac determinants of functional status. In addition, a comparison with the natural decrease in exercise capacity in healthy subjects (in both children and adults) is lacking. This single-center study aims to investigate the functional status in a cohort of Fontan patients in relation to time since Fontan completion and to identify its determinants, including cardiac characteristics and pulmonary characteristics...
August 1, 2017: American Journal of Cardiology
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