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Lamis Baydoun, Fook Chang Lam, Sontje Schaal, Shugi Hsien, Silke Oellerich, Korine van Dijk, Gerrit R J Melles
PURPOSE: To assess aqueous flare as a measure of subclinical inflammation after Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy. METHODS: In this prospective cross-sectional and longitudinal case series at a tertiary referral center, 173 DMEK eyes of 169 patients and 19 age-matched healthy control eyes were included. Aqueous flare [photon count per millisecond (ph/ms)] was assessed by laser flare photometry at 1 day, 1 week, and 1 month after DMEK in group I (evaluation of postsurgical blood-aqueous barrier recovery; n = 25) and on average 28 (±19) months (range, 3-86 months) after DMEK in group II (evaluation of long-term inflammation; n = 148)...
March 15, 2018: Cornea
Rosa Roemers, Jolanda Kluin, Frederiek de Heer, Sara Arrigoni, Regina Bökenkamp, Joost van Melle, Tjark Ebels, Mark Hazekamp
OBJECTIVES: Supravalvar aortic stenosis (SVAS) is a rare congenital anomaly. The "single-patch technique," "'two sinus augmentation with an inverted Y-patch" (both nonsymmetrical corrections), "three-patch technique," and the "slide aortoplasty" (both symmetrical corrections) are the techniques implemented by the majority of surgeons for the correction of SVAS. In the few studies that compared these techniques, no technique was shown to be superior over another...
March 2018: World Journal for Pediatric & Congenital Heart Surgery
Djoeke Wolff, Henricus B M van de Wiel, Mirthe E de Muinck Keizer, Joost P van Melle, Petronella G Pieper, Rolf M F Berger, Tjark Ebels, Willebrord C M Weijmar Schultz
OBJECTIVE: To get an impression of the quality of life (QOL) and sexual well-being in the Fontan population, and to generate hypotheses for future research. METHODS: For this cross-sectional pilot study, questionnaires regarding health-related QOL, sexual function and fertility/pregnancy were completed by 21 patients with a Fontan circulation >16 years old, followed at the University Medical Center Groningen, the Netherlands. Semi-structured qualitative interviews were conducted in 8 patients...
March 12, 2018: Congenital Heart Disease
Anita Harrewijn, Melle J W van der Molen, Irene M van Vliet, Renaud L M Tissier, P Michiel Westenberg
Social anxiety disorder is an invalidating psychiatric disorder characterized by extreme fear and avoidance of one or more social situations in which patients might experience scrutiny by others. The goal of this two-generation family study was to delineate behavioral and electrocortical endophenotypes of social anxiety disorder related to social evaluation. Nine families of patients with social anxiety disorder (their spouse and children, and siblings of these patients with spouse and children) performed a social judgment paradigm in which they believed to be evaluated by peers...
2018: NeuroImage: Clinical
Melle J W van der Molen, Anita Harrewijn, P Michiel Westenberg
The current study examined neural and behavioral responses to social evaluative feedback processing in social anxiety. Twenty-two non-socially and 17 socially anxious females (mean age = 19.57 years) participated in a Social Judgment Paradigm in which they received acceptance/rejection feedback that was either congruent or incongruent with their prior predictions. Results indicated that socially anxious participants believed they would receive less social acceptance feedback than non-socially anxious participants...
March 7, 2018: Biological Psychology
Nada Abdulaziz, Anjali R Shah, William J McCune
PURPOSE OF REVIEW: Antimalarial drugs including chloroquine, its less toxic quinolone-derivative hydroxychloroquine (HCQ), and quinacrine have become cornerstones in the treatment of autoimmune diseases including systemic lupus, rheumatoid arthritis, sarcoidosis, and Sjogren syndrome; cutaneous disorders, antiphospholipid syndrome, and have recently been employed at higher dioses in oncology. Benefits include anti-inflammatory effects, protection against thrombosis, and improved control of hyperglycemia and hyperlipidemia...
March 6, 2018: Current Opinion in Rheumatology
Eva Z Hoseth, Florian Krull, Ingrid Dieset, Ragni H Mørch, Sigrun Hope, Erlend S Gardsjord, Nils Eiel Steen, Ingrid Melle, Hans-Richard Brattbakk, Vidar M Steen, Pål Aukrust, Srdjan Djurovic, Ole A Andreassen, Thor Ueland
The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with evidence of subtle neurodevelopmental, structural and functional neuronal abnormalities. We aimed to elucidate the role of aberrant regulation of the Wnt system in these disorders by evaluating plasma levels of secreted Wnt modulators in patients (SCZ = 551 and BD = 246) and healthy controls (HCs = 639) using enzyme immune-assay...
March 6, 2018: Translational Psychiatry
G E Melling, S E Flannery, S A Abidin, H Clemmens, P Prajapati, E E Hinsley, S Hunt, J W F Catto, R D Coletta, M Mellone, G J Thomas, E K Parkinson, S S Prime, I C Paterson, D J Buttle, D W Lambert
The dissemination of cancer cells to local and distant sites depends on a complex and poorly understood interplay between malignant cells and the cellular and non-cellular components surrounding them, collectively termed the tumour microenvironment. One of the most abundant cell types of the tumour microenvironment is the fibroblast, which becomes corrupted by locally derived cues such as TGF-β1 and acquires an altered, heterogeneous phenotype (cancer-associated fibroblast, CAF) supportive of tumour cell invasion and metastasis...
February 28, 2018: Carcinogenesis
Wayne Nishio Ayre, Genevieve Melling, Camille Cuveillier, Madhan Natarajan, Jessica L Roberts, Lucy L Marsh, Christopher D Lynch, Jean-Yves Maillard, Stephen P Denyer, Alastair J Sloan
This study investigated the host response to a polymicrobial pulpal infection consisting of Streptococcus anginosus and Enterococcus faecalis , bacteria commonly implicated in dental abscesses and endodontic failure, using a validated ex vivo rat tooth model. Tooth slices were inoculated with planktonic cultures of S. anginosus or E. faecalis alone or in co-culture at ratios of 50:50 and 90:10 S. anginosus to E. faecalis Attachment was semi-quantified by measuring area covered by fluorescently labelled bacteria...
February 26, 2018: Infection and Immunity
Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Zale Mednick, Mohammad Kreimei, Clara C Chan, David S Rootman
PURPOSE: To suggest a new surgical approach for posterior opacities or persistent Descemet membrane (DM) detachment in failed deep anterior lamellar keratoplasty (DALK) and to report the outcome of Descemet membrane endothelial keratoplasty (DMEK) in a series of patients with DALK failure. METHODS: In this retrospective case series of patients who underwent DMEK for failed DALK at Toronto Western Hospital, 4 patients with failed DALK who underwent DMEK surgery were included...
February 22, 2018: Cornea
Shermel Sherman, Nadeen Sarsour, Marziyeh Salehi, Allen Schroering, Blair Mell, Bina Joe, Jennifer W Hill
BACKGROUND: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant...
February 22, 2018: Gut Microbes
Isabel J Boero, Anthony J Paravati, Jiayi Hou, Erin F Gillespie, Anna Schoenbrunner, Jonathan Unkart, Anne M Wallace, John P Einck, Loren K Mell, James D Murphy
OBJECTIVE: This study evaluates the impact of individual surgeons and institutions on the use of mastectomy or breast conserving surgery (BCS) among elderly women with breast cancer. SUMMARY OF BACKGROUND DATA: Current literature characterizes patient clinical and demographic factors that increase likelihood of mastectomy use. However, the impact of the individual provider or institution is not well understood, and could provide key insights to biases in the decision-making process...
February 20, 2018: Annals of Surgery
Karen Thomson, Corline Brouwers, Olga C Damman, Martine C de Bruijne, Danielle Rm Timmermans, Marijke Melles
BACKGROUND: Medication nonadherence poses a serious and a hard-to-tackle problem for many chronic diseases. Electronic health (eHealth) apps that foster patient engagement and shared decision making (SDM) may be a novel approach to improve medication adherence. OBJECTIVE: The aim of this study was to investigate the perspective of health care professionals regarding a newly developed digital app aimed to improve medication adherence. Familial hypercholesterolemia (FH) was chosen as a case example...
February 20, 2018: JMIR Human Factors
Jaap I van Waning, Kadir Caliskan, Yvonne M Hoedemaekers, Karin Y van Spaendonck-Zwarts, Annette F Baas, S Matthijs Boekholdt, Joost P van Melle, Arco J Teske, Folkert W Asselbergs, Ad P C M Backx, Gideon J du Marchie Sarvaas, Michiel Dalinghaus, Johannes M P J Breur, Marijke P M Linschoten, Laura A Verlooij, Isabella Kardys, Dennis Dooijes, Ronald H Lekanne Deprez, Arne S IJpma, Maarten P van den Berg, Robert M W Hofstra, Marjon A van Slegtenhorst, Jan D H Jongbloed, Danielle Majoor-Krakauer
BACKGROUND: The clinical outcomes of noncompaction cardiomyopathy (NCCM) range from asymptomatic to heart failure, arrhythmias, and sudden cardiac death. Genetics play an important role in NCCM. OBJECTIVES: This study investigated the correlations among genetics, clinical features, and outcomes in adults and children diagnosed with NCCM. METHODS: A retrospective multicenter study from 4 cardiogenetic centers in the Netherlands classified 327 unrelated NCCM patients into 3 categories: 1) genetic, with a mutation in 32% (81 adults; 23 children) of patients; 2) probably genetic, familial cardiomyopathy without a mutation in 16% (45 adults; 8 children) of patients; or 3) sporadic, no family history, without mutation in 52% (149 adults; 21 children) of patients...
February 20, 2018: Journal of the American College of Cardiology
Korine van Dijk, Jack S Parker, Lamis Baydoun, Abbas Ilyas, Isabel Dapena, Esther A Groeneveld-van Beek, Gerrit R J Melles
PURPOSE: The purpose of this study was to evaluate the 5-year clinical results of isolated Bowman layer (BL) transplantation in the treatment of advanced keratoconus. METHODS: In this prospective, single-center, interventional case series at a tertiary referral center, 20 eyes of 17 patients with advanced keratoconus underwent BL transplantation, i.e. an isolated Bowman layer graft was positioned into a manually dissected mid-stromal pocket. Scheimpflug-based corneal tomography measurements, best corrected spectacle and contact lens visual acuities (BSCVA and BCLVA), endothelial cell density, and complications were evaluated up to 5 years after surgery...
February 14, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Lynn Mørch-Johnsen, Stener Nerland, Kjetil N Jørgensen, Kåre Osnes, Cecilie B Hartberg, Ole A Andreassen, Ingrid Melle, Ragnar Nesvåg, Ingrid Agartz
OBJECTIVES: We aimed to investigate morphometric correlates of auditory hallucinations in bipolar disorder (BD) by comparing cortical thickness and cortical surface area in bipolar disorder patients with (BD+) and without (BD-) a lifetime history of auditory hallucinations. Based on previous findings in schizophrenia patients, we hypothesized that the cortex would be thinner in the auditory cortex in BD+ compared to BD-. METHODS: Bipolar disorder spectrum (n = 157) patients and healthy controls (n = 279) underwent 1...
February 13, 2018: Bipolar Disorders
Mathieu Nacher, Leila Adriouch, Astrid Van Melle, Marie-Claire Parriault, Antoine Adenis, Pierre Couppié
BACKGROUND: Over 75% of patients in the HIV cohort in French Guiana are of foreign origin. Our objective was to estimate what proportion of the migrant population of HIV-infected patients in Cayenne had been infected in French Guiana. METHODS: We included patients of known foreign origin who were followed in Cayenne, for whom the year of arrival in French Guiana was known and the initial CD4 count at the time of diagnosis was available. The time between seroconversion and time at diagnosis was estimated using the formula [square root (CD4 at seroconversion)-square root(CD4 at HIV diagnosis)] / slope of CD4 decline...
2018: PloS One
Huai Huang, Tao Yang, Qiangqiang Shao, Tanushree Majumder, Kristopher Mell, Guofa Liu
Heterozygous missense mutations in human TUBB3 gene result in a spectrum of brain malformations associated with defects in axon guidance, neuronal migration and differentiation. However, the molecular mechanisms underlying mutation-related axon guidance abnormalities are unclear. Recent studies have shown that netrin-1, a canonical guidance cue, induced the interaction of TUBB3 with the netrin receptor deleted in colorectal cancer (DCC). Furthermore, TUBB3 is required for netrin-1-induced axon outgrowth, branching and pathfinding...
January 27, 2018: Neuroscience
Ashley Azar, Ibiyonu Lawrence, Sebastian Jofre, Joshua Mell, Christian Sell
Both methionine restriction and rapamycin treatment are robust longevity-enhancing regimens for which the mechanisms remain unclear. Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin regimens delay or prevent activation of the senescence program in human cells. Using a transcriptome-wide analysis, we examined the impact of methionine restriction and rapamycin treatment on senescence-associated gene expression in human cardiac fibroblasts. Our findings have been integrated into gene expression data sets from human lung and skin fibroblasts during senescence...
January 28, 2018: Annals of the New York Academy of Sciences
Eva J Brandl, Nora Dietrich, Nicoleta Mell, Johanna Winkler, Stefan Gutwinski, Joachim Bretz, Meryam Schouler-Ocak
OBJECTIVE: A better understanding of specific sociodemographic and clinical factors in patients with migration background may help to significantly improve psychiatric treatment outcome of these patients. Therefore, we investigated these factors in a large sample of psychiatric outpatients. METHODS: N = 423 psychiatric patients of a large outpatient service were assessed for sociodemographic variables as well as clinical variables including diagnosis, psychopharmacological treatment, treatment duration and current symptom load (SCL-14)...
January 23, 2018: Psychiatrische Praxis
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