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Local anesthetics

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https://www.readbyqxmd.com/read/29926357/preperitoneal-bupivacaine-infiltration-reduces-postoperative-opioid-consumption-acute-pain-and-chronic-postsurgical-pain-after-bariatric-surgery-a-randomized-controlled-trial
#1
Saskia L Boerboom, Ann de Haes, Lianne Vd Wetering, Edo O Aarts, Ignace M C Janssen, Jose W Geurts, Ed T Kamphuis
INTRODUCTION: A multimodal pain treatment including local anesthetics is advised for perioperative analgesia in bariatric surgery. Due to obesity, bariatric surgery patients are at risk of respiratory complications. Opioid consumption is an important risk factor for hypoventilation. Furthermore, acute postoperative pain is an important risk factor for chronic postsurgical pain. In this study, we aimed to evaluate whether preperitoneal anesthesia with bupivacaine would reduce pain and opioid consumption after bariatric surgery...
June 20, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29925727/-similarity-of-clinically-significant-neuropsychiatric-adverse-reactions-listed-in-package-inserts-between-the-anti-influenza-drugs-oseltamivir-and-amantadine-possibility-attributable-to-common-pharmacological-effects
#2
Hideki Ono, Maya Okamura, Akihiro Fukushima
<bibitem lang="en">  The anti-influenza virus drug oseltamivir has been reported to have several pharmacological actions including blocking of nicotinic acetylcholine receptor channels and activation of the dopaminergic system. These pharmacological actions highly overlap those of amantadine, another anti-influenza virus drug authorized in Japan, and ester-type local anesthetics. Moreover, oseltamivir and amantadine can clinically induce similar adverse neuropsychiatric reactions. In the present study, from the database of the Pharmaceuticals and Medical Devices Agency (PMDA), we surveyed 2,576 drugs for which neuropsychiatric side effects similar to those of oseltamivir, amantadine and local anesthetics (abnormal behavior, confusion, consciousness disturbance, convulsion, delirium, delusion, hallucination, myoclonus, tremor) are listed as "clinically significant adverse reactions", and found 327 that had at least one of these adverse reactions...
June 20, 2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29924762/evaluation-of-the-plasmatic-level-of-mepivacaine-in-different-anatomical-regions
#3
J-C-A Ferreira, I-S Catunda, B-C-E Vasconcelos, K-A-A da Silva, E-F-C Nogueira, E-E Vidal
BACKGROUND: To evaluate the serum level of the local anesthetic mepivacaine 3% without vasoconstrictor in patients who underwent procedures performed in the anterior and posterior maxilla, through a method of possible extraction to quantify it in human plasma by high performance liquid chromatography (HPLC). MATERIAL AND METHODS: This was a hybrid study consisting of 18 patients (7 females and 11 males) classified as ASA I, adults and with normal body mass index, submitted to procedures in the anterior region (group I) and posterior region of the maxilla (group II)...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29923981/abrupt-hemodynamic-changes-accompanying-intrapleural-hyperthermic-chemotherapy-case-series
#4
Hyae-Jin Kim, Hyeon-Jeong Lee, Eunsoo Kim, Jihwan Yun
RATIONALE: Intrapleural hyperthermic chemotherapy (IPHC) is the preferred method to locally treat lung cancer with pleural seeding. Anesthetic management during IPHC is a very challenging task for the anesthesiologist because of the hemodynamic instability associated with the procedure; however, there is no report on anesthetic considerations during the IPHC procedure. PATIENT CONCERNS: Three patients who diagnosed lung cancer with pleural invasion scheduled for IPHC were reported in this case series...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923955/lipid-emulsion-pretreatment-decreased-the-maximum-total-and-free-plasma-concentration-of-levobupivacaine-for-femoral-and-sciatic-nerve-block-in-below-knee-fracture-surgery
#5
Ying Chen, Jian Zhang, Zhe Chen, Quanguang Wang, Bing Li, Rujing Lai, Xuzhong Xu, Zhifang Cao, Lizhen Yu
BACKGROUND AND OBJECTIVES: Although intravenous lipid emulsion has been proved a powerful antidote for local anesthetic toxicity, there are few pharmacokinetic data on using lipid infusion as a pretreatment for other clinical applications. We assessed the influence of lipid pretreatment on the pharmacodynamics and pharmacokinetics of levobupivacaine. METHODS: Altogether, 12 patients undergoing below-knee surgery for a fracture were randomly assigned to 2 groups (6 patients per group): pretreatment with 1...
June 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29923954/is-a-retrolaminar-approach-to-the-thoracic-paravertebral-space-possible-a-human-cadaveric-study
#6
A Sassan Sabouri, Lane Crawford, Sarah K Bick, Ala Nozari, Thomas A Anderson
BACKGROUND AND OBJECTIVES: The retrolaminar block (RB) is used for truncal analgesia, but its mechanism of neural blockade remains obscure. We sought to learn the pattern of local anesthetic spread after thoracic RB using cadaveric models. METHODS: In 8 fresh cadavers, an ultrasound-guided T4 RB was performed with 20 mL of methylene blue 1% and bupivacaine 0.5%. For comparison, an RB at T9 in 1 cadaver and a T4 thoracic paravertebral block in another cadaver were performed...
June 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29923159/dynamics-of-spontaneous-activity-in-random-networks-with-multiple-neuron-subtypes-and-synaptic-noise-spontaneous-activity-in-networks-with-synaptic-noise
#7
Rodrigo F O Pena, Michael A Zaks, Antonio C Roque
Spontaneous cortical population activity exhibits a multitude of oscillatory patterns, which often display synchrony during slow-wave sleep or under certain anesthetics and stay asynchronous during quiet wakefulness. The mechanisms behind these cortical states and transitions among them are not completely understood. Here we study spontaneous population activity patterns in random networks of spiking neurons of mixed types modeled by Izhikevich equations. Neurons are coupled by conductance-based synapses subject to synaptic noise...
June 19, 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29922684/welfare-effects-of-the-use-of-a-combination-of-local-anesthesia-and-nsaid-for-disbudding-analgesia-in-dairy-calves-reviewed-across-different-welfare-concerns
#8
REVIEW
Mette S Herskin, Bodil H Nielsen
Across the international dairy industry, the vast majority of dairy herds have dehorned cows. Farmers choose to dehorn calves for different reasons such as easier handling of non-horned cattle and reduced risk of injuries in animals and staff. This review focuses on disbudding by use of hot-iron cautery as is practiced by dairy farmers in calves <3 months of age. We examine welfare effects of the use of NSAIDs in combination with a local anesthetic including indicators relevant for the three major welfare concerns-affective states, basic health, and functioning as well as the possibility to behave naturally...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29921893/pharmacological-interventions-for-premature-ejaculation-a-mixed-treatment-comparison-network-meta-analysis-of-randomized-clinical-trials
#9
Kannan Sridharan, Gowri Sivaramakrishnan, Reginald P Sequeira, Khalid Aj Al-Khaja
Premature ejaculation (PE) is the most common sexual dysfunction in men. The present study is a network meta-analysis of drugs used for treating PE. Electronic databases were searched for randomized controlled trials comparing medical interventions with either placebo or with other active drugs in patients with PE. Inverse variance heterogeneity model was used for mixed-treatment comparisons. Intravaginal ejaculatory latency time (IELT) and adverse events were the main outcome measures. A total of 44 studies were included in the meta-analysis...
June 20, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29914785/the-optimal-concentration-of-bupivacaine-and-levobupivacaine-for-labor-pain-management-using-patient-controlled-epidural-analgesia-a-double-blind-randomized-controlled-trial
#10
V Baliuliene, A Macas, K Rimaitis
BACKGROUND: The study aim was to evaluate the efficacy and safety of different low concentrations of two local anesthetics for labor analgesia using patient-controlled epidural analgesia. METHODS: A double-blind, randomized controlled trial recruiting healthy nulliparous women was conducted from 2014 to 2016. Epidural analgesia was provided using local anesthetic and fentanyl. Patients were allocated to six groups, according to the concentration of bupivacaine or levobupivacaine (0...
May 18, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29914782/a-randomized-trial-comparing-surgeon-administered-intraoperative-transversus-abdominis-plane-block-with-anesthesiologist-administered-transcutaneous-block
#11
D M Narasimhulu, L Scharfman, H Minkoff, B George, P Homel, K Tyagaraj
BACKGROUND: Injection of local anesthetic into the transversus abdominis plane (TAP block) decreases systemic morphine requirements after abdominal surgery. We compared intraoperative surgeon-administered TAP block (surgical TAP) to anesthesiologist-administered transcutaneous ultrasound-guided TAP block (conventional TAP) for post-cesarean analgesia. We hypothesized that surgical TAP blocks would take less time to perform than conventional TAP blocks. METHODS: We performed a randomized trial, recruiting 41 women undergoing cesarean delivery under neuraxial anesthesia, assigning them to either surgical TAP block (n=20) or conventional TAP block (n=21)...
April 27, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29914426/effects-of-local-anesthetics-on-breast-cancer-cell-viability-and-migration
#12
Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P Dilger, Jun Lin
BACKGROUND: Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery. Retrospective clinical studies have suggested that use of regional anesthesia leads to improved patient outcomes. Laboratory studies have reported that breast cancer cells are inhibited by some local anesthetics at millimolar concentration. Here, we present a comprehensive analysis of the effects of six common local anesthetics on two human breast cancer cell lines...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29914237/the-effects-of-preadministration-of-local-anesthetic-on-pulsed-radiofrequency
#13
Tülin Arıcı, Mustafa Kurçaloğlu, İdris Şevki Köken, Bora Uzuner, Can Eyigör, Meltem Uyar
Background/aim: Pulsed radiofrequency (PRF) has been reported to be a safe and reliable method for the management of a variety of chronic pain syndromes. It is not known whether the preadministration of local anesthetic increases the size of the electrical field. We revealed the effects of administering local anesthetic on PRF and investigated whether they were related to local anesthetic or fluid effects. Materials and methods: Group 1 (n = 18) received PRF to the suprascapular nerve with 1 mL of bupivacaine, group 2 (n = 20) received PRF with 1 mL of physiological saline solution, and group 3 (n = 18) received PRF only...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29913831/pulsed-radiofrequency-in-peripheral-posttraumatic-neuropathic-pain-a-double-blind-sham-controlled-randomized-clinical-trial
#14
Ethem Akural, Voitto Järvimäki, Raija Korhonen, Hannu Kautiainen, Maija Haanpää
Background and purpose Pulsed radiofrequency (PRF) is widely used for the treatment of chronic pain, although its mechanism of action is not known. The evidence of efficacy of PRF for neuropathic pain (NP) conditions is limited. A double-blind, randomized, sham-controlled parallel study was conducted to evaluate the efficacy and safety of PRF in the treatment of peripheral posttraumatic NP. Methods Forty-five patients with peripheral posttraumatic NP in their upper or lower limb were randomly assigned to receive PRF or sham treatment to the injured peripheral nerve (s) causing peripheral posttraumatic NP...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910676/lipid-emulsion-for-treating-local-anesthetic-systemic-toxicity
#15
REVIEW
Seong-Ho Ok, Jeong-Min Hong, Soo Hee Lee, Ju-Tae Sohn
Lipid emulsion has been shown to be an effective treatment for systemic toxicity induced by local anesthetics, which is reflected in case reports. A systemic review and meta-analysis confirm the efficacy of this treatment. Investigators have suggested mechanisms associated with the lipid emulsion-mediated recovery of cardiovascular collapse caused by local anesthetic systemic toxicity; these mechanisms include lipid sink, a widely accepted theory in which highly soluble local anesthetics (particularly bupivacaine) are absorbed into the lipid phase of plasma from tissues (e...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29910631/clonidine-versus-other-adjuncts-added-to-local-anesthetics-for-pediatric-neuraxial-blocks-a-systematic-review-and-meta-analysis
#16
REVIEW
Yang Yang, Ling-Yu Yu, Wen-Sheng Zhang
Background: Clonidine is a common adjunct to local anesthetics for pediatric neuraxial block; however, the pros and cons between clonidine and other adjuncts remain unclear. Thus, we performed this meta-analysis of randomized controlled trials to assess the efficacy and adverse effects between clonidine and other adjuncts added to local anesthetics. Materials and methods: The systematic search, data extraction, critical appraisal, and pooled analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29909157/fullerenol-c-60-oh-36-at-relatively-high-concentrations-impairs-hippocampal-theta-oscillations-in-vivo-and-in-vitro-and-triggers-epilepsy-in-vitro-a-dose-response-study
#17
Paulina Kazmierska, Anna Kobrzycka, Renata Bocian, Tomasz Kowalczyk, Anita Krokosz, Jacek Grebowski
Since the first identification of fullerenes (C60 ) and their synthesis in 1985, those compounds have been extensively studied in the biomedical field. In particular, their water-soluble derivatives, fullerenols (C60 (OH)n, n = 2-48), have recently been the subject of numerous investigations concerning their antioxidant and prooxidant properties in biological systems. A small fraction of that research has focused on the possible use of C60 and C60 (OH)n in neuroscience and the therapy of pathologies such as dementia, amyloid-β (Aβ) formation, and Parkinson's disease...
June 14, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29908799/measurement-of-dairy-calf-behavior-prior-to-onset-of-clinical-disease-and-in-response-to-disbudding-using-automated-calf-feeders-and-accelerometers
#18
M A Sutherland, G L Lowe, F J Huddart, J R Waas, M Stewart
We determined if feeding and lying behavior, recorded by automatic calf feeding systems (ACFS) and accelerometers, could be used to detect changes in behavior before onset of neonatal calf diarrhea (NCD) or in response to disbudding pain in dairy calves. At 4 d of age, 112 calves had accelerometers attached to their hind leg and were housed in pens with ACFS. Calves were examined daily for signs of illness or injury. Of the 112 calves monitored, 18 were diagnosed with NCD; activities of calves with NCD were then compared with those of 18 healthy controls (calves that had no symptoms of NCD, other illnesses, or injury)...
June 13, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29908312/detection-of-neural-light-scattering-activity-in-vivo-optical-transmittance-studies-in-the-rat-brain
#19
Wen-Ju Pan, Seung Yup Lee, Jacob Billings, Maysam Nezafati, Waqas Majeed, Erin Buckley, Shella Keilholz
Optical studies of ex vivo brain slices where blood is absent show that neural activity is accompanied by significant intrinsic optical signals (IOS) related to activity-dependent scattering changes in neural tissue. However, the neural scattering signals have been largely ignored in vivo in widely-used IOS methods where absorption contrast from hemoglobin was employed. Changes in scattering were observed on a time scale of seconds in previous brain slice IOS studies, similar to the time scale for the hemodynamic response...
June 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29907575/current-evidence-for-anesthesia-management-during-endovascular-stroke-therapy-updated-systematic-review-and-meta-analysis
#20
Nitin Goyal, Konark Malhotra, Muhammad F Ishfaq, Georgios Tsivgoulis, Christopher Nickele, Daniel Hoit, Adam S Arthur, Andrei V Alexandrov, Lucas Elijovich
INTRODUCTION: Debate continues about the optimal anesthetic management for patients undergoing endovascular treatment (ET) of acute ischemic stroke due to emergent large vessel occlusion. OBJECTIVE: To compare, using current evidence, the clinical outcomes and procedural characteristics among patients undergoing general anesthesia (GA) and local or monitored anesthesia (non-GA). METHODS: We performed a systematic review and meta-analysis of all available studies that involved the use of stent retrievers for ET (stentriever group)...
June 15, 2018: Journal of Neurointerventional Surgery
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