keyword
https://read.qxmd.com/read/38537241/pre-incisional-local-infiltration-with-levobupivacaine-in-laparoscopic-cholecystectomy-a-randomized-and-clinical-trial
#1
JOURNAL ARTICLE
Jorge Herrador-Benito, Javier Páramo-Zunzunegui, Gil Rodríguez-Caravaca, Manuel Durán-Poveda
OBJECTIVE: Laparoscopic cholecystectomy (LC), despite its minimally invasive nature, requires effective control of post-operative pain. The use of local anesthetics (LA) has been studied, but the level of evidence is low, and there is little information on important parameters such as health-related quality of life (HRQoL) or return to work. The objective of the study was to evaluate the efficacy of 0.50% levobupivacaine infiltration of incisional sites in reducing POP after LC. METHODS: This was a prospective, randomized, double-blind study...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38532430/needle%C3%A2-based-gastrocnemius-lengthening-a-novel-ultrasound%C3%A2-guided-noninvasive-technique-part-ii-clinical-results
#2
JOURNAL ARTICLE
A Iborra, M Villanueva, H Fahandezh-Saddi Díaz
BACKGROUND: Isolated gastrocnemius contracture has been associated with more than 30 lower limb disorders, including plantar heel pain/plantar fasciitis, Achilles tendinosis, equinus foot, adult flatfoot, and metatarsalgia. Although many techniques are available for gastrocnemius recession, potential anesthetic, cosmetic, and wound-related complications can lead to patient dissatisfaction. Open and endoscopic recession techniques usually require epidural or general anesthesia, exsanguination of the lower extremities and stitches and can damage the sural nerve, which is not under the complete control of the surgeon at all stages of the procedure...
March 26, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38528475/the-effect-of-different-endotracheal-tube-cuff-pressure-monitoring-systems-on-postoperative-sore-throat-in-patients-undergoing-tracheal-intubation-a-randomized-clinical-trial
#3
RANDOMIZED CONTROLLED TRIAL
Guangli Zhu, Xuan Wang, Xinyu Cao, Chongya Yang, Bin Wang, Yang Ang, Manlin Duan
BACKGROUND: Postoperative sore throat (POST) is an unpleasant outcome that can occur as a result of tracheal intubation in adults. Increased pressure from the endotracheal tube (ETT) cuff often leads to local mucosal injury, resulting in sore throat. The purpose of this study was to compare the effect of two different ETT cuff pressure monitoring systems vs. no cuff pressure monitoring on the incidence and severity of POST in adults. METHODS: One hundred and fourteen ASA I-III patients of either gender, aged 18-65 years, and undergoing surgery requiring endotracheal intubation were included in this study...
March 25, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38524792/alternative-statistical-modeling-for-radical-prostatectomy-data
#4
JOURNAL ARTICLE
Julio C S Vasconcelos, Thiago da Costa Travassos, Edwin M M Ortega, Gauss M Cordeiro, Leonardo Oliveira Reis
Several statistical models have been proposed in recent years, among them is the semiparametric regression. In medicine, there are several situations in which it is impracticable to consider a linear regression for statistical modeling, especially when the data contain explanatory variables that present a nonlinear relationship with the response variable. Another common situation is when the response variable does not have a unimodal shape, and it is not possible to adopt distributions belonging to the symmetric or asymmetric classes...
2024: Journal of Applied Statistics
https://read.qxmd.com/read/38524054/comparative-evaluation-of-the-anesthetic-efficacy-of-needle-free-anesthesia-and-conventional-anesthesia-in-patients-with-symptomatic-irreversible-pulpitis-a-randomized-clinical-trial
#5
JOURNAL ARTICLE
Krishna Kanth Jaju, Iffat Nasim, Sahil Choudhari, Hima Sandeep A
Introduction Pain is the primary reason for which most of the patients seek endodontic treatment. Local anesthesia is considered to be the most important step in the procedure to reduce the pain. However, the majority of the patients do not cooperate due to the fear of syringe anesthesia. The aim of this clinical trial was to compare the anesthetic efficacy of needle-free anesthesia and conventional anesthesia in patients with symptomatic irreversible pulpitis undergoing root canal therapy. Materials and methods A total of 54 patients were enrolled in the study, and the treatment was administered by a single operator...
February 2024: Curēus
https://read.qxmd.com/read/38523299/ropivacaine-as-a-novel-akt1-specific-inhibitor-regulates-the-stemness-of-breast-cancer
#6
JOURNAL ARTICLE
Lin Ding, Hui Jiang, Qiangwei Li, Qiushuang Li, Tian-Tian Zhang, Limeng Shang, Bin Xie, Yaling Zhu, Keshuo Ding, Xuanming Shi, Tao Zhu, Yong Zhu
BACKGROUND: Ropivacaine, a local anesthetic, exhibits anti-tumor effects in various cancer types. However, its specific functions and the molecular mechanisms involved in breast cancer cell stemness remain elusive. METHODS: The effects of ropivacaine on breast cancer stemness were investigated by in vitro and in vivo assays (i.e., FACs, MTT assay, mammosphere formation assay, transwell assays, western blot, and xenograft model). RNA-seq, bioinformatics analysis, Western blot, Luciferase reporter assay, and CHIP assay were used to explore the mechanistic roles of ropivacaine subsequently...
March 25, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38522941/synthesis-of-ottonia-anisum-extract-mediated-zno-nps-and-their-local-anesthetic-analgesic-and-hcl%C3%A2-induced-acute-lung-injury-activities
#7
JOURNAL ARTICLE
Guiqin Fan, Jing Yu, Zhengzheng Tao, Xingjia Qian, Qinghong Qian, Jun Shu, Dongfang Shi, Luhong Shen, Bing Lu, Hong Lv
In this study, we outlined the green synthesis of Zinc oxide nanoparticles (ZnO NPs) using the plant-mediated method. Employing the nitrate derivative of Zinc and the extract from the native medicinal plant, Ottonia anisum, the nanoparticles were effectively produced. After obtaining a yellow-colored paste, it was meticulously dried, gathered, and set aside for subsequent examination. The UV-visible spectrometry analysis indicated an absorption peak at 320 nm, which is indicative of ZnO NPs. Characterization techniques, such as XRD and HR-TEM, confirmed the existence of agglomerated ZnO NPs with an average diameter of 40 nm...
March 25, 2024: Journal of Oleo Science
https://read.qxmd.com/read/38516832/enhanced-recovery-after-surgery-eras-in-prolapse-repair-a-prospective-study-on-pre-emptive-uterosacral-cervical-block
#8
JOURNAL ARTICLE
Marta Barba, Alice Cola, Desirèe De Vicari, Tomaso Melocchi, Mauro Angelo Gili, Matteo Frigerio
OBJECTIVE: Enhanced recovery after surgery (ERAS) protocols have been introduced in gynecology. Postoperative pain management after vaginal procedures remains a relevant issue. In the present study we aimed to evaluate the effectiveness of pre-emptive uterosacral/cervical block (PUCB) for postoperative pain control in patients with uterovaginal prolapse undergoing vaginal hysterectomy and pelvic floor repair. We also evaluated the impact on the length of recovery. METHODS: This was a pilot study analyzing 40 women who underwent pelvic organ prolapse repair through uterosacral ligament suspension...
March 22, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38514192/the-mouse-inferior-colliculus-responds-preferentially-to-non-ultrasonic-vocalizations
#9
JOURNAL ARTICLE
Mahtab Tehrani, Sharad Shanbhag, Julia J Huyck, Rahi Patel, Diana Kazimiersky, Jeffrey J Wenstrup
The inferior colliculus (IC), the midbrain auditory integration center, analyzes information about social vocalizations and provides substrates for higher level processing of vocal signals. We used multi-channel recordings to characterize and localize responses to social vocalizations and synthetic stimuli within the IC of female and male mice, both urethane-anesthetized and unanesthetized. We compared responses to ultrasonic vocalizations (USVs) with other vocalizations in the mouse repertoire and related vocal responses to frequency tuning, IC subdivisions, and sex...
March 21, 2024: ENeuro
https://read.qxmd.com/read/38513640/-common-and-new-regional-anaesthesia-techniques-under-review-from-head-to-abdomen
#10
JOURNAL ARTICLE
Thorsten Steinfeldt, Andreas Marx, Mark Dauster
By implementation of sonography regional anesthesia became more relevant in the daily practice of anesthesia and pain therapy. Due to visualized needle guidance ultrasound supports more safety during needle placement. Thereby new truncal blocks got enabled. Next to the blocking of specific nerve structures, plane blocks got established which can also be described as interfascial compartment blocks. The present review illustrates published and established blocks in daily practice concerning indications and the procedural issues...
March 2024: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://read.qxmd.com/read/38512601/mitigating-factors-in-l4-and-l5-medial-branch-motor-stimulation-during-radiofrequency-ablation
#11
REVIEW
Mihir Jani, Nimesha Mehta, Sandra Yu, Ricky Ju, Ugur Yener, Alaa Abd-Elsayed, Lynn Kohan, Sayed Emal Wahezi
PURPOSE OF REVIEW: Radiofrequency ablation (RFA) is a minimally invasive procedure for facet joint pain. The targets for the procedure are the medial branches of the dorsal spinal nerves which innervate the facet joints. Before RFA, patients undergo diagnostic meal branch blocks to ensure appropriate pain relief and confirm the utility of proceeding to RFA. The success of RFA relies heavily on procedural technique and accurate placement near the medial branch. RECENT FINDINGS: Motor testing is utilized in the lumbar region to assess the response of the multifidus and ensure proper placement of the RFA probe to prevent inadvertent damage to surrounding spinal anatomy...
March 21, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38512321/adjunctive-effect-of-photobiomodulation-therapy-with-nd-yag-laser-in-the-treatment-of-inferior-alveolar-nerve-paresthesia
#12
JOURNAL ARTICLE
Javad Yazdani, Hosein Eslami, MohamadAli Ghavimi, Meghdad Eslami
Background : Disruption of peripheral branches of the trigeminal nerve in the field of maxillofacial surgery is a known risk due to the close connection of these branches with the bony structures of the maxilla and mandible. As a result, injuries of the lingual nerve and inferior alveolar nerve take place within routine maxillofacial surgery procedures, including local anesthetic injection, wisdom tooth surgery, and dental implant placement, resulting in paresthesia and dysesthesia. During the last three decades, low-level lasers (LLL) have been frequently used in various medical fields...
March 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38508691/evaluation-of-efficacy-of-2-extended-release-bupivacaine-products-in-a-porcine-model-of-incisional-pain
#13
JOURNAL ARTICLE
Peggy Yang, Stephanie Yang, Laura B Durham, Patrick A Lester, Daniel D Myers
Extended-release (ER) local anesthetics are often incorporated in multi-modal analgesia or as an alternative when the effect of systemic analgesics may confound research. In this study, we compared the analgesic efficacy of 2 ER bupivacaine anesthetics with different ER mechanisms, a slow-release bupivacaine-meloxicam polymer (BMP) and a sucrose acetate isobutyrate bupivacaine (SABER-B) system. We used a full-thickness unilateral skin incision porcine model to evaluate the efficacy of these 2 ER bupivacaine analgesics...
March 20, 2024: Journal of the American Association for Laboratory Animal Science: JAALAS
https://read.qxmd.com/read/38506678/a-systematic-review-and-meta-analysis-of-the-analgesic-effects-of-lidocaine-administered-intravenously-or-intraperitoneally-post-abdominal-surgery
#14
JOURNAL ARTICLE
Yanmei Bi, Min Diao, Yunkai Tao, Hao Li, Xuemei Lin
BACKGROUND: Reducing postoperative pain is still a tremendous challenge for perioperative clinicians. Lidocaine is a local anesthetic that belongs to the amide class and has anti-inflammatory, anti-hyperalgesic, and analgesic effects. Extensive research has been conducted to determine the optimal route for its administration. OBJECTIVE: To compare the efficacy of perioperative intravenous lidocaine with that of intraperitoneal lidocaine on postoperative analgesia in patients undergoing abdominal surgery...
March 2024: Pain Physician
https://read.qxmd.com/read/38506120/a-rare-complication-of-lumbar-plexus-block-tadpole-pupil-and-edinger-westphal-nucleus-involvement-due-to-possible-subdural-spread-of-local-anesthetic
#15
JOURNAL ARTICLE
Canan Yilmaz, Hande Gurbuz, Filiz Ata, Mehmet Gamli
No abstract text is available yet for this article.
March 20, 2024: Minerva Anestesiologica
https://read.qxmd.com/read/38505137/isolated-lateral-sided-knee-pain-in-total-knee-arthroplasty-a-review
#16
JOURNAL ARTICLE
Naga Suresh Cheppalli, Prabhudev Prasad Purudappa, Ryan Price, Yogesh Kolwadkar, Sreenivasulu Metikala
Isolated lateral-sided knee pain is a unique problem following total knee arthroplasty (TKA). Reported causes include soft tissue impingement against extruded cement, an overhanging tibial tray, remnant osteophytes rubbing against the iliotibial band (ITB), popliteal tendon impingement, fabella syndrome, and synovial tissue impingement in the lateral gutter. In addition, iliotibial band traction syndrome secondary to guided motion Bi-cruciate stabilizing knee arthroplasty has been recognized as a new clinical entity...
2024: Orthopedic Reviews
https://read.qxmd.com/read/38504848/trial-watch-local-anesthetics-in-cancer-therapy
#17
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu
Preclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together reduce the proliferative, invasive and migratory potential of malignant cells. Although some retrospective and correlative studies support these findings, prospective randomized controlled trials have not yet fully confirmed the antineoplastic activity of local anesthetics, likely due to the intricate methodology required for mitigating confounding factors...
2024: Oncoimmunology
https://read.qxmd.com/read/38504220/comparison-of-diffusion-ranges-at-different-local-anesthetic-volumes-during-superior-laryngeal-nerve-block
#18
JOURNAL ARTICLE
Yin Bao, Huijun Wang, Lifeng Li, Hongbo Xu, Yun Li, Guyan Wang
OBJECTIVES: Ultrasound-guided superior laryngeal nerve (SLN) block is a practical and painless approach to avoid the hemodynamic stress response during endotracheal intubation and relieve sore throat after laryngeal surgery. The main purpose of this study was to establish an optimal dosage of local anesthetic when performing SLN block to help anesthetists balance analgesia and side effects. METHODS: Twenty fresh larynx specimens were obtained immediately after resection and then injected with 2-, 3-, 4-, or 5- mL of a lidocaine-blue dye mixture at bilateral SLN puncture sites...
March 19, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38504037/ambulatory-total-hip-and-knee-arthroplasty-a-literature-review-and-perioperative-considerations
#19
JOURNAL ARTICLE
Vivian H Y Ip, Vishal Uppal, Kwesi Kwofie, Ushma Shah, Patrick B Y Wong
PURPOSE: Total joint arthroplasty (TJA), particularly for the hip and knee, is one of the most commonly performed surgical procedures. The advancement/evolution of surgical and anesthesia techniques have allowed TJA to be performed on an ambulatory/same-day discharge basis. In this Continuing Professional Development module, we synthesize the perioperative evidence that may aid the development of successful ambulatory TJA pathways. SOURCE: We searched MEDLINE, Embase, CENTRAL, and the Cochrane Database of Systematic Reviews for ambulatory or fast-track TJA articles...
March 19, 2024: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/38497855/a-simple-technical-innovation-to-prevent-needle-stick-injuries-among-dental-professionals
#20
JOURNAL ARTICLE
N Tabassum, M Rida Dimashkieh, V Chowdary Jasthi, F Murdhi AlEnazi, A Mohamed Mostafa Kamal, S M Kumar, A Al Qerban, A Mohidin Demachkia, A Al Salem, A Swapna Lingam, G Khalid Faisal Alfirm, S Ahmed, M Noushad, M Z Nassani
OBJECTIVE: Dental healthcare personnel face the potential danger of being exposed to infectious patients while administering local anesthesia injections during dental operations. This could lead to unintentional transfer of infectious diseases from patients to physicians. Although safety measures such as the One-hand-scoop technique and the use of safety syringes, plastic needle cap holders, and needles with safety caps are in place, there have been instances of needle stick injuries reported in clinics...
March 2024: European Review for Medical and Pharmacological Sciences
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