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Complex Regional Pain Syndrome (CRPS)

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https://www.readbyqxmd.com/read/28178071/recommendations-for-a-first-core-outcome-measurement-set-for-complex-regional-pain-syndrome-clinical-studies-compact
#1
Grieve Sharon, Perez Roberto Sgm, Birklein Frank, Brunner Florian, Bruehl Stephen, Harden R Norman, Packham Tara, Gobeil Francois, Haigh Richard, Holly Janet, Terkelsen Astrid, Davies Lindsay, Lewis Jennifer, Thomassen Ilona, Connett Robyn, Worth Tina, Vatine Jean-Jacques, McCabe Candida S
Complex Regional Pain Syndrome (CRPS) is a persistent pain condition that remains incompletely understood and challenging to treat. Historically, a wide range of different outcome measures have been used to capture the multidimensional nature of CRPS. This has been a significant limiting factor in the advancement of our understanding of the mechanisms and management of CRPS.In 2013, an international consortium of patients, clinicians, researchers and industry representatives was established, to develop and agree on a minimum core set of standardised outcome measures for use in future CRPS clinical research, including but not limited to clinical trials within adult populationsThe development of a core measurement set was informed through workshops and supplementary work, using an iterative consensus process...
February 4, 2017: Pain
https://www.readbyqxmd.com/read/28162677/-429-create-1-study-a-randomized-double-blind-placebo-controlled-study-to-assess-the-efficacy-and-safety-of-axs-02-disodium-zoledronate-tetrahydrate-administered-orally-to-subjects-with-complex-regional-pain-syndrome-type-1-crps-1
#2
L Kapural, A Goebel, M Serpell, A Jones, R Kaye, H Tabuteau
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162531/-118-physical-and-psychological-predictors-of-dysfunction-in-complex-regional-pain-syndrome-crps-a-collaborative-health-outcomes-information-registry-choir-study
#3
M Adelus, J Sturgeon, T Rico, V Tawfik, S Mackey
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162448/-218-characterization-of-patients-with-complex-regional-pain-syndrome-crps-in-a-tertiary-care-pain-management-setting-a-collaborative-health-outcomes-information-registry-choir-study
#4
M Adelus, J Sturgeon, T Rico, V Tawfik, S Mackey
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28158163/prevalence-of-specific-types-of-pain-diagnoses-in-a-sample-of-united-states-adults
#5
Kelly Ryan Murphy, Jing L Han, Siyun Yang, Syed Mohammed Qasim Hussaini, Aladine A Elsamadicy, Beth Parente, Jichun Xie, Promila Pagadala, Shivanand P Lad
BACKGROUND: Patients with pain conditions place significant demands on health care services globally. Health economists have reported the annual economic cost of pain in the United States as high as $635 billion. A common challenge in treating patients suffering from chronic pain conditions is accurate diagnosis and treatment. OBJECTIVE: The aim of this study was to determine the modern-day prevalence of individual types of pain diagnoses in adults. STUDY DESIGN: Retrospective analysis of Truven MarketScan® Commercial and Medicare Supplemental database...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28146319/unimpaired-endogenous-pain-inhibition-in-the-early-phase-of-complex-regional-pain-syndrome
#6
N Kumowski, T Hegelmaier, J Kolbenschlag, C Maier, T Mainka, J Vollert, E Enax-Krumova
BACKGROUND: The complex regional pain syndrome (CRPS) is characterized by distal generalisation of pain beyond the initial trauma. This might be the result of impaired endogenous pain inhibition. METHOD: We compared Conditioned Pain Modulation (CPM) between patients with CRPS (n = 24; pain: 4.5 ± 2.2, NRS 0-10; disease duration <1 year), neuralgia (n = 17; pain: 5.5 ± 1.1) and healthy subjects (n = 23) and its correlation with loss and gain of function as assessed by Quantitative Sensory Testing (QST)...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28144268/comparison-of-effects-of-seven-treatment-methods-for-distal-radius-fracture-on-minimizing-complex-regional-pain-syndrome
#7
Jian-Hang Wang, Tao Sun
INTRODUCTION: Using network meta-analysis, we evaluated the adverse effects of the seven most common treatment methods, i.e., bridging external fixation, non-bridging external fixation, K-wire fixation, plaster fixation, dorsal plating, volar plating, and dorsal and volar plating, by their associated risk of developing complex regional pain syndrome (CRPS) in distal radius fracture (DRF) patients. MATERIAL AND METHODS: Following an exhaustive search of scientific literature databases for high quality studies, randomized controlled trials (RCTs) related to our study topic were screened and selected based on stringent predefined inclusion and exclusion criteria...
February 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28142335/complex-regional-pain-syndrome-in-children-a-systematic-review-of-clinical-features-and-movement-disorders
#8
Hashem Abu-Arafeh, Ishaq Abu-Arafeh
AIM: To ascertain clinical features of complex regional pain syndrome (CRPS) in children with a focus on movement disorders. METHODS: all publications with original data on children with CRPS were assessed. Data were tabulated and descriptive statistics were applied. RESULTS: One population-based study and nine clinic-based studies provided data on demographic and clinical characteristics of childhood CRPS. Mean age of onset was 12.5 years and 85% of patients were females (risk ratio: 1...
February 1, 2017: Pain Management
https://www.readbyqxmd.com/read/28138314/the-therapeutic-effect-of-vitamin-c-in-an-animal-model-of-complex-regional-pain-syndrome-produced-by-prolonged-hindpaw-ischemia-reperfusion-in-rats
#9
Jae Hun Kim, Yong Chul Kim, Francis Sahngun Nahm, Pyung Bok Lee
Objectives: It is known that increased free radicals from oxidative stress are one of the major causes of complex regional pain syndrome (CRPS). In this study, we tested the hypothesis that vitamin C has a dose-related treatment effect in a chronic post-ischemic pain (CPIP) model. Methods: A total of 49 male rats weighing 250 to 350 g were used. The 4 treatment groups were control (no medication), group 1.0 (administration of 1 mg/day for vitamin C for 5 days), group 2.5 (administration of 2.5 mg/day vitamin C for 5 days), and group 7...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28138265/optimal-control-of-reaching-is-disturbed-in-complex-regional-pain-syndrome-a-single-case-study
#10
Michihiro Osumi, Masahiko Sumitani, Shin-Ichiro Kumagaya, Shu Morioka
OBJECTIVE: Disturbance of goal-directed motor control may cause or exacerbate pathological pain in patients with complex regional pain syndrome (CRPS). We conducted a single-case study about motor control involved in reaching with a patient with CRPS in an upper limb. METHODS: Using a three-dimensional measurement system, we recorded reaching movement trajectories of the intact and affected hand before and after pain alleviation by therapeutic nerve blockade. We assessed degrees of tremor in the acceleration phase (from start until maximum peak velocity) and the deceleration phase (from maximum peak velocity until goal)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28127572/complex-regional-pain-syndrome-a-recent-update
#11
REVIEW
En Lin Goh, Swathikan Chidambaram, Daqing Ma
Complex regional pain syndrome (CRPS) is a debilitating condition affecting the limbs that can be induced by surgery or trauma. This condition can complicate recovery and impair one's functional and psychological well-being. The wide variety of terminology loosely used to describe CRPS in the past has led to misdiagnosis of this condition, resulting in poor evidence-base regarding the treatment modalities available and their impact. The aim of this review is to report on the recent progress in the understanding of the epidemiology, pathophysiology and treatment of CRPS and to discuss novel approaches in treating this condition...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28072810/high-frequency-spinal-cord-stimulation-for-complex-regional-pain-syndrome-a-case-report
#12
Joseph T Crapanzano, Lisa M Harrison-Bernard, Mark R Jones, Alan D Kaye, Erich O Richter, Mordeci N Potash
Complex regional pain syndrome (CRPS) is a chronic, debilitating, neuropathic pain condition which is often misdiagnosed, difficult to manage, and lacks proven methods for remission. Most available methods provide some relief to a small percentage of patients. Recent FDA approval and superiority of the Nevro Senza 10-kHz high frequency (HF10) spinal cord stimulation (SCS) therapy over traditional low-frequency spinal cord stimulation for treatment of chronic back and leg pain may provide a new interventional therapeutic option for patients suffering from CRPS...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072749/ultrasound-guided-pulsed-radiofrequency-treatment-of-the-cervical-sympathetic-chain-for-complex-regional-pain-syndrome-a-retrospective-observational-study
#13
Eung Don Kim, Woo Joo Yoo, Yoo Na Kim, Hue Jung Park
The stellate ganglion is a common target to manage neuropathic pain in the upper extremities. However, the effect duration of a single stellate ganglion block is often temporary. To overcome the short-term effects of a single sympathetic block, pulsed radiofrequency (PRF) can be applied. The aim of the present study was to investigate the efficacy of PRF on the cervical sympathetic chain under ultrasound guidance for complex regional pain syndrome (CRPS).Twelve CRPS patients who underwent PRF on the cervical sympathetic chain were enrolled in this retrospective analysis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072713/-11c-r-pk11195-positron-emission-tomography-in-patients-with-complex-regional-pain-syndrome-a-pilot-study
#14
So Yeon Jeon, Seongho Seo, Jae Sung Lee, Soo-Hee Choi, Do-Hyeong Lee, Ye-Ha Jung, Man-Kyu Song, Kyung-Jun Lee, Yong Chul Kim, Hyun Woo Kwon, Hyung-Jun Im, Dong Soo Lee, Gi Jeong Cheon, Do-Hyung Kang
Complex regional pain syndrome (CRPS) is characterized by severe and chronic pain, but the pathophysiology of this disease are not clearly understood. The primary aim of our case-control study was to explore neuroinflammation in patients with CRPS using positron emission tomography (PET), with an 18-kDa translocator protein specific radioligand [C]-(R)-PK11195. [C]-(R)-PK11195 PET scans were acquired for 11 patients with CRPS (30-55 years) and 12 control subjects (30-52 years). Parametric image of distribution volume ratio (DVR) for each participant was generated by applying a relative equilibrium-based graphical analysis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28062308/bone-trauma-causes-massive-but-reversible-changes-in-spinal-circuitry
#15
Silke Hirsch, Alaa Ibrahim, Laura Krämer, Fabiola Escolano-Lozano, Tanja Schlereth, Frank Birklein
: Bone fracture with subsequent immobilization of the injured limb can cause complex regional pain syndrome (CRPS) in humans. Mechanisms of CRPS are still not completely understood but bone fracture with casting in mice leads to a similar post-traumatic inflammation as seen in humans and might therefore be an analog to human CRPS. In this article we report behavioral and spinal electrophysiological changes in mice that developed swelling of the paw, warming of the skin, and pain in the injured limb after bone fracture...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28044002/abdominal-wall-type-i-complex-regional-pain-syndrome-treated-effectively-with-peripheral-nerve-field-stimulation-a-case-report
#16
Linqiu Zhou, Henry Chou, Eric Holder
Chronic abdominal wall pain is a well-documented complication of abdominal surgery. However, abdominal wall complex regional pain syndrome (CRPS) is a rare medical condition. We present a case of abdominal wall CRPS and its treatment with peripheral nerve field stimulation (PNfS). A 34-year-old female presented with right periumbilical pain for 2 years. She developed burning, sharp and stabbing pain with allodynia (extremely sensitive to wind and light touch) and erythema or pallor 2 weeks after an exploratory appendectomy...
January 2, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28033251/multicenter-study-on-the-asymmetry-of-skin-temperature-in-complex-regional-pain-syndrome-an-examination-of-temperature-distribution-and-symptom-duration
#17
MULTICENTER STUDY
Chan Woo Cho, Francis Sahngun Nahm, Eunjoo Choi, Pyung-Bok Lee, In-Ki Jang, Chul Joong Lee, Yong Chul Kim, Sang Chul Lee
According to the International Association for the Study of Pain (IASP) and American Medical Association (AMA), the diagnostic criteria for complex regional pain syndrome (CRPS) require the presence of skin temperature asymmetry. In CRPS, it is generally accepted that the temperature of skin of affected limbs changes from warm to cold; however, in our clinical practice, we have experienced many cases with different thermographic characteristics. Therefore, we conducted a retrospective multicenter study that examined the distribution of skin temperature in patients with CRPS and skin temperature asymmetry versus symptom duration...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28031726/complex-regional-pain-syndrome-medical-and-legal-ramifications-of-clinical-variability-and-experience-and-perspective-of-a-practicing-clinician
#18
R P Lazaro
OBJECTIVE: The aim of this study was to demonstrate the ramifications of clinical variability of complex regional pain syndrome (CRPS) and how they can affect the various aspects of this condition, favorably or unfavorably, for both patients and participating medical and legal professionals. METHODS: Twelve patients diagnosed with CRPS at different times in the past 25 years were followed up, and their signs and symptoms were reviewed for variability. None had preexisting or ongoing medical disorders and prior injury to the peripheral nerves or musculoskeletal tissues...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28030470/dorsal-root-ganglion-stimulation-yielded-higher-treatment-success-rate-for-crps-and-causalgia-at-3-and-12-months-randomized-comparative-trial
#19
Timothy R Deer, Robert M Levy, Jeffrey Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Allen W Burton, Abram H Burgher, Jon Obray, James Scowcroft, Stan Golovac, Leonardo Kapural, Richard Paicius, Christopher Kim, Jason Pope, Thomas Yearwood, Sam Samuel, W Porter McRoberts, Hazmer Cassim, Mark Netherton, Nathan Miller, Michael Schaufele, Edward Tavel, Timothy Davis, Kristina Davis, Linda Johnson, Nagy Mekhail
Animal and human studies indicate that electrical stimulation of DRG neurons may modulate neuropathic pain signals.ACCURATE, a pivotal, prospective, multi-center, randomized-comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome (CRPS) or causalgia in the lower extremities. Subjects received neurostimulation of the DRG or dorsal column (SCS). The primary endpoint was a composite of safety and efficacy at 3 months and subjects were assessed through 12 months for long term outcomes and adverse events...
December 23, 2016: Pain
https://www.readbyqxmd.com/read/28025368/analysis-of-common-single-nucleotide-polymorphisms-in-complex-regional-pain-syndrome-genome-wide-association-study-approach-and-pooled-dna-strategy
#20
Piotr K Janicki, Guillermo M Alexander, Jill Eckert, Marek Postula, Robert J Schwartzman
OBJECTIVE: The objective of this study was to use a genome-wide association (GWAS) approach and pooled DNA strategy to search for new genomic loci associated with complex regional pain syndrome (CRPS). DESIGN: The study cohort consisted of 230 patients with established diagnosis of CRPS. The control group consisted of 230 age- and gender-matched subjects without chronic pain. We tested the association of common single nucleotide polymorphisms (SNPs), genotyped using a high-density microarray platform, with CRPS phenotype...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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