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IL-17 cytokines

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https://www.readbyqxmd.com/read/29054755/association-of-polymorphic-variants-in-il1b-gene-with-secretion-of-il-1%C3%AE-protein-and-inflammatory-markers-in-north-indian-rheumatoid-arthritis-patients
#1
Mohd Jahid, Rehan-Ul-Haq, Diwesh Chawla, Rajnish Avasthi, Rafat Sultana Ahmed
The proinflammatory cytokine interleukin-1beta (IL-1β) is a key mediator of inflammation which affects cell proliferation and differentiation. IL-1β is considered to contribute to the pathophysiology of rheumatoid arthritis (RA). Polymorphisms in cytokine genes are highly influenced by ethnicity. Hence, in this study polymorphism of the IL1B-511(C/T) within promoter region was analyzed by using polymerase chain reaction-restriction fragment length Polymorphism (PCR-RFLP) in 187 RA patients and 214 controls...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29053869/enzymatic-hydrolysis-of-fumonisins-in-the-gastrointestinal-tract-of-broiler-chickens
#2
B Grenier, H E Schwartz-Zimmermann, C Gruber-Dorninger, I Dohnal, M Aleschko, G Schatzmayr, W D Moll, T J Applegate
Fumonisins (FB) are among the most frequently detected mycotoxins in feedstuffs and finished feed, and recent data suggest that the functions of the gastrointestinal tract (GIT) in poultry species might be compromised at doses ranging from 10 to 20 mg/kg, close to field incidences and below the US and EU guidelines. Strategies are therefore necessary to reduce the exposure of poultry to FB. In the present study, we assessed the efficacy of fumonisin esterase FumD (EC 3.1.1.87, commercial name FUMzyme®) to cleave the tricarballylic acid side chains of FB, leading to the formation of non-toxic hydrolyzed fumonisins in the GIT of broiler chickens...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053834/effect-of-feed-supplementation-with-zinc-glycine-chelate-and-zinc-sulfate-on-cytokine-and-immunoglobulin-gene-expression-profiles-in-chicken-intestinal-tissue
#3
L Jarosz, A Marek, Z Gradzki, M Kwiecien, B Zylinska, B Kaczmarek
The aim of the study was to evaluate the effect of inorganic and organic forms of Zn on the expression of cytokines (IL-2, TNF-α, IFN-γ, IL-12, IL-17, IL-4, IL-10, and TGF-β) and immunoglobulins (IgA and IgG) in the tissues of the small intestine (jejunum and ileum) of broiler chickens. In the experiment, 90 broiler chickens were divided into 4 experimental groups and a control group, with 18 birds each. The birds received Zn supplements in inorganic form with and without phytase (ZnSO4 and ZnSO4 + F), and in organic form with glycine, with and without phytase (Zn-Gly and Zn-Gly + F)...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29052125/differences-in-innate-ifn%C3%AE-and-il-17-responses-to-bordetella-pertussis-between-balb-c-and-c57bl-6-mice-role-of-%C3%AE-%C3%AE-t-cells-nk-cells-and-dendritic-cells
#4
Yung-Yi C Mosley, Fangjia Lu, Harm HogenEsch
Cell-mediated immune responses characterized by the secretion of IFNγ and IL-17 play an important role in the immune response to Bordetella pertussis (B. pertussis). We investigated innate sources of IFNγ and IL-17 upon stimulation of spleen cells from BALB/c (B/c) and C57BL/6 (B6) mice with heat-killed B. pertussis (hkBp). Spleen cells from B/c mice secreted less IFNγ and more IL-17 than those from B6 mice. Innate IFNγ was produced predominantly by NK cells in B/c mice and by CD8 T cells and NK cells in B6 mice...
October 19, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29049348/chronic-administration-of-fluoxetine-and-pro-inflammatory-cytokine-change-in-a-rat-model-of-depression
#5
Yanxia Lu, Cyrus S Ho, Xin Liu, Anna N Chua, Wei Wang, Roger S McIntyre, Roger C Ho
This study evaluated the chronic effects of fluoxetine, a commonly prescribed SSRI antidepressant, on the peripheral and central levels of inflammatory cytokines including IL-1β, IL-6, TNF-α and IL-17 over a 4-interval in a rat model of chronic mild stress (CMS) which resembles the human experience of depression. Twenty-four Sprague-Dawley rats were randomly assigned to CMS+vehicle (n = 9), CMS+fluoxetine (n = 9) and the control (n = 6) groups. Sucrose preference and forced swim tests were performed to assess behavioral change...
2017: PloS One
https://www.readbyqxmd.com/read/29048509/plasma-but-not-cerebrospinal-fluid-interleukin-7-and-interleukin-5-levels-pre-antiretroviral-therapy-commencement-predict-cryptococcosis-associated-immune-reconstitution-inflammatory-syndrome
#6
Ngomu Akeem Akilimali, Christina C Chang, Daniel M Muema, Tarylee Reddy, Mahomed-Yunus S Moosa, Sharon R Lewin, Martyn A French, Thumbi Ndung'u
Background: Patients with human immunodeficiency virus/AIDS-associated cryptococcal meningitis (CM) frequently experience clinical deterioration, known as cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS), upon initiation of antiretroviral therapy (ART). The immunological mechanisms underlying C-IRIS are incompletely defined and no reliable predictive biomarkers exist. We investigated whether plasma or cerebrospinal fluid (CSF) levels of cytokines and chemokines predicted C-IRIS and are potential predictive biomarkers...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29046188/association-of-imbalance-of-effector-t-cells-and-regulatory-cells-with-the-severity-of-asthma-and-allergic-rhinitis-in-children
#7
Fei Huang, Jia-Ning Yin, Hong-Bo Wang, Shou-Yue Liu, Ya-Nan Li
PURPOSE: This study investigated the frequency and absolute numbers of different subsets of peripheral blood cells, including CD4+ T cells and CD19+ interleukin (IL) 10+ B regulatory cells (Breg) and their potential association with clinical laboratory measurements in children diagnosed with simple asthma or asthma plus allergic rhinitis (AR). METHOD: The frequency and numbers of peripheral blood CD4+ interferon (IFN) gamma+ T-helper (Th) type 1, CD4+ IL-4+ Th2, CD4+ IL-17A+ Th17, CD4+CD25+ Forkhead Box P3+ regulatory T cells (Treg) and CD19+ IL-10+ Bregs in 22 children with asthma, 17 children with asthma and AR, and 25 healthy controls were determined by flow cytometry...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046031/-innate-lymphoid-cells-and-their-role-in-immune-response-regulation
#8
Bibiana Patricia Ruiz-Sánchez, David Cruz-Zárate, Iris Estrada-García, Isabel Wong-Baeza
Innate lymphoid cells (ILCs) are lymphocytes lacking antigen recognition receptors and become activated in response to cytokines and through microbe-associated molecular pattern (MAMP) receptors. ILCs are found mainly in mucosal tissues and participate in the immune response against infections and in chronic inflammatory conditions. ILCs are divided in ILC-1, ILC-2 and ILC-3, and these cells have analogue functions to those of immune adaptive response lymphocytes Th1, Th2 and Th17. ILC-1 express T-bet, produce IFNγ, protect against infections with intracellular microorganisms and are related to inflammatory bowel disease immunopathology...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29043545/early-brain-injury-associated-with-systemic-inflammation-after-subarachnoid-hemorrhage
#9
Jude Savarraj, Kaushik Parsha, Georgene Hergenroeder, Sungho Ahn, Tiffany R Chang, Dong H Kim, H Alex Choi
BACKGROUND: Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) is defined as brain injury occurring within 72 h of aneurysmal rupture. Although EBI is the most significant predictor of outcomes after aSAH, its underlying pathophysiology is not well understood. We hypothesize that EBI after aSAH is associated with an increase in peripheral inflammation measured by cytokine expression levels and changes in associations between cytokines. METHODS: aSAH patients were enrolled into a prospective observational study and were assessed for markers of EBI: global cerebral edema (GCE), subarachnoid hemorrhage early brain edema score (SEBES), and Hunt-Hess grade...
October 17, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29042990/changes-of-treg-and-th17-cells-as-well-as-cytokines-in-children-with-acute-bronchitis
#10
Zhiqiang Tu, Haiyan Xue, Wei Chen, Lanfang Cao, Weiqi Zhang
The present study aimed to investigate changes of T-regulatory (Treg) and T-helper (Th)17 cells as well as cytokines in peripheral blood of children with acute bronchitis, and to explore the roles of these cells in the pathogenesis of acute bronchitis. A total of 126 children who had presented at Renji Hospital (Shanghai, China) with acute bronchitis were selected as the observation group and 30 healthy children were selected as the control group. Th17/Tregs in the peripheral blood of the children of the observation group and the control group was detected by flow cytometry...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042954/dexmedetomidine-ameliorates-the-inflammatory-immune-response-in-rats-with-acute-kidney-damage
#11
Weihua Liu, Wenli Yu, Yiqi Weng, Yongwang Wang, Mingwei Sheng
It has been demonstrated that dexmedetomidine (Dex) can protect patients with acute kidney injury from experiencing further tissue damage, however its mechanism of action remains unclear. The present study investigated the immune modulatory functions of Dex in rats with acute kidney injury (AKI) induced via injection of lipopolysaccharide into the tail vein. ELISA analysis showed that Dex reduced the levels of inflammatory cytokines in rats with AKI in a dose dependent manner. Furthermore, the regulatory effects of Dex on cytokine production disappeared when the α-2 adrenergic receptor antagonist Yohimbine (YOH) was added...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040945/quercetin-protects-mouse-liver-against-triptolide-induced-hepatic-injury-by-restoring-th17-treg-balance-through-tim-3-and-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#12
Cai-Bing Wei, Kun Tao, Rong Jiang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
Triptolide (TP) is a diterpene triepoxide with various biological activities, but its clinical applications have been limited by potential hepatotoxicity, which can be attributed to T helper 17 (Th17)/T regulatory (Treg) cell imbalance. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties, including hepatoprotective activity against TP-induced liver injury. However, the hepatoprotection mechanisms have not been clarified. The present study was designed to explore the protective effect and the mechanism of QE against TP-induced liver injury...
October 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29039484/mir%C3%A2-203-contributes-to-il%C3%A2-17%C3%A2-induced-vegf-secretion-by-targeting-socs3-in-keratinocytes
#13
Yuanyuan Xu, Yongzhi Ji, Xiaoou Lan, Xinghua Gao, Hong-Duo Chen, Long Geng
Interleukin (IL)-17 signaling serves an important role in the development and pathogenesis of psoriasis; a chronic skin disease characterized by increased dermal vascularity and the hyperproliferation of keratinocytes. microRNA (miR)‑203 is preferentially expressed in the skin and is an important regulator of keratinocyte differentiation. miR‑203 has been implicated in a number of skin diseases, including psoriasis. However, the role of miR‑203 in IL‑17‑induced vascular endothelial growth factor (VEGF) secretion has yet to be elucidated...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039449/crosstalk-between-tlr2-and-sphk1-in-microglia-in-the-cerebral-ischemia-reperfusion-induced-inflammatory-response
#14
Wei Sun, Zhaoming Ding, Shengjie Xu, Zhiqiang Su, Hulun Li
Stroke is associated with high morbidity and mortality, and much remains unknown about the injury-related mechanisms that occur following reperfusion. This study aimed to explore the roles of Toll-like receptor 2 (TLR2) and sphingosine kinase 1 (Sphk1) in microglial cells in inflammatory responses induced by cerebral ischemia/reperfusion (I/R). For this purpose, C57BL/6 mice were randomly divided into 4 groups as follows: the sham-operated group, the I/R group, the I/R group treated with TLR2 antibody, and the I/R group treated with N,N-dimethylsphingosine...
September 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29036304/il-1r-and-myd88-signaling-in-cd4-t-cells-promote-th17-immunity-and-atherosclerosis
#15
Daniel Engelbertsen, Sara Rattik, Maria Wigren, Jenifer Vallejo, Goran Marinkovic, Alexandru Schiopu, Harry Björkbacka, Jan Nilsson, Eva Bengtsson
Aims: The role of CD4+ T cells in atherosclerosis has been shown to be dependent on cytokine cues that regulate lineage commitment into mature T helper subsets. In this study we tested the roles of IL-1R1 and MyD88 signaling in CD4+ T cells in atherosclerosis. Methods and results: We transferred apoe-/-myd88+/+or apoe-/-myd88-/- CD4+ T cells to T- and B-cell-deficient rag1-/-apoe-/- mice fed high fat diet. Mice given apoe-/-myd88-/- CD4+ T cells exhibited reduced atherosclerosis compared to mice given apoe-/-myd88+/+ CD4+ T cells...
September 28, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29035886/response-gene-to-complement-32-promotes-the-imbalance-of-treg-th17-in-patients-with-dilated-cardiomyopathy
#16
Bailing Li, Wei Zhou, Xiaojun Tang, Wei Wang, Jiajun Pan, Mengwei Tan
BACKGROUND/AIMS: The imbalance of Treg/Th17 cells plays important role in the pathogenesis of dilated cardiomyopathy (DCM). Response gene to complement (RGC)-32 is a cell cycle regulator that plays an important role in cell proliferation. We evaluated whether the upregulation of RGC-32 was implicated in the homeostasis of Treg/Th17 cells in DCM. METHODS: The levels of plasma RGC-32, IL-17 and TGF-β1, and the frequencies of circulating CD4+ RGC-32+ T cells, Th17 and Treg cells in patients with DCM were determined by Cytokine-specific sandwich ELISA and the flow cytometer (FCM), respectively...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29034213/a-promising-listeria-vectored-vaccine-induces-th1-type-immune-responses-and-confers-protection-against-tuberculosis
#17
Yuelan Yin, Kai Lian, Dan Zhao, Chengwu Tao, Xiang Chen, Weijun Tan, Xiaobo Wang, Zhengzhong Xu, Maozhi Hu, Yan Rao, Xiaohui Zhou, Zhiming Pan, Xiaoming Zhang, Xin'an Jiao
Deaths associated with tuberculosis (TB) is rising and accounted for 1.4 million deaths in 2015 many of which were due to drug-resistant bacteria. Vaccines represent an important medical intervention, but the current Bacilli Calmette-Guerin (BCG) vaccine is not ideal for the protection of teenagers and adults. Therefore, a safe and effective vaccine is urgently needed. In this study, we designed a novel vaccine using an attenuated Listeria monocytogenes strain carrying fusion antigen FbpB-ESAT-6 (rLM) and characterized its safety and protective efficacy against Mycobacterium tuberculosis (M...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29033929/immunity-and-fibrogenesis-the-role-of-th17-il-17-axis-in-hbv-and-hcv-induced-chronic-hepatitis-and-progression-to-cirrhosis
#18
REVIEW
Feliciano Chanana Paquissi
Cirrhosis is a common final pathway for most chronic liver diseases; representing an increasing burden worldwide and is associated with increased morbidity and mortality. Current evidence has shown that, after an initial injury, the immune response has a significant participation in the ongoing damage, and progression from chronic viral hepatitis (CVH) to cirrhosis, driving the activation and maintenance of main fibrogenic pathways. Among immune deregulations, those related to the subtype 17 of T helper lymphocytes (Th17)/interleukin-17 (IL-17) axis have been recognized as key immunopathological and prognostic elements in patients with CVH...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29031634/fecal-bacteria-from-treatment-naive-crohn-s-disease-patients-can-skew-helper-t-cell-responses
#19
Fei Ma, Yi Zhang, Junjie Xing, Xiaoling Song, Ling Huang, Hao Weng, Xiangsong Wu, Emma Walker, Zhongchuan Wang
Many studies have demonstrated that the inflamed mucosa of Crohn's disease (CD) patients presented a disturbed gut commensal community, and the shift in microbial composition and species variety is associated with disease severity. To establish a link between changes in the intestinal bacterial composition and the alteration of inflammation, we obtained fecal bacteria from CD patients and non-CD controls. The bacteria were then used to stimulate the peripheral blood mononuclear cells (PBMCs) from one non-CD individual...
October 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29030006/dexmedetomidine-mitigate-acute-lung-injury-by-inhibiting-il-17-induced-inflammatory-reaction
#20
Yong Zhang, Shushan Jia, Tianqin Gao, Ruyi Zhang, Zhaoguo Liu, Yaoqi Wang
Interleukin-17 (IL-17) is considered to play an important role in the pathogenesis of a number of inflammatory conditions. Previous studies demonstrated that intranasal injections of IL-17 resulted in pulmonary inflammation and lung damage, we therefore hypothesize that dexmedetomidine, a potent α2 adrenergic receptor agonist that shows anti-inflammation effects in several animal models of inflammation, would attenuate IL-17 induced lung injury. We examined the lung damage using a histological approach, and assessed the number of lung-infiltrating neutrophils in the bronchoalveolar lavage fluid...
October 7, 2017: Immunobiology
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