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https://www.readbyqxmd.com/read/27883296/adjuvant-trastuzumab-a-10-year-overview-of-its-benefit
#1
Matteo Lambertini, Noam F Pondé, Cinzia Solinas, Evandro de Azambuja
Anti-HER2 targeted therapy is one of the key advances in the treatment of breast cancer that have occurred in the last 20 years. In the adjuvant setting, the use of trastuzumab has led to prolonged and sustained survival benefit with very little toxicity as also confirmed by the 10-year follow-up results from the pivotal trials. Despite the survival improvement, several key issues are not entirely resolved in this field. These issues have led to multiple research efforts in de-escalating or escalating the standard treatment with chemotherapy and 1 year of adjuvant trastuzumab...
November 24, 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27879534/physician-provided-prehospital-critical-care-effect-on-patient-physiology-dynamics-and-on-scene-time
#2
Bjørn O Reid, Marius Rehn, Oddvar Uleberg, Andreas J Krüger
INTRODUCTION: Improved physiologic status can be seen as a surrogate measure of improved outcome and a field-friendly prognostic model such as the Mainz Emergency Evaluation Score (MEES) could quantify the effect on physiological response. We aim to examine the dynamic physiological profile as measured by this score on patients managed by physician-manned helicopter emergency medical services and how this profile was related to on-scene time expenditure and critical care interventions...
November 22, 2016: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/27832046/periodic-discharges-insight-from-magnetoencephalography
#3
V Shvarts, G Zoltay, S M Bowyer, A Zillgitt, J E Moran, K Mason R, N Tepley, D Burdette
PURPOSE: This study utilized magnetoencephalography (MEG) dipole localization and coherence measurement to evaluate the magnetic fields associated with periodic discharges. The primary goal of the study was to evaluate whether MEG could consistently localize quasiperiodic discharges that were observed on the EEG portion of the recording. The secondary objective was to evaluate whether coherence measurements would correlate with topographic maxima of epileptiform activity. METHODS: A total of 13 inpatients, whose electrographic records demonstrated lateralized periodic discharges (LPDs), were recruited from Henry Ford Hospital neurology and intensive care units...
November 9, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27756644/intraoperative-modifiable-risk-factors-of-colorectal-anastomotic-leakage-why-surgeons-and-anesthesiologists-should-act-together
#4
REVIEW
S J van Rooijen, D Huisman, M Stuijvenberg, J Stens, R M H Roumen, F Daams, G D Slooter
BACKGROUND: Colorectal anastomotic leakage (CAL) is a major surgical complication in intestinal surgery. Despite many optimizations in patient care, the incidence of CAL is stable (3-19%) [1]. Previous research mainly focused on determining patient and surgery related risk factors. Intraoperative non-surgery related risk factors for anastomotic healing also contribute to surgical outcome. This review offers an overview of potential modifiable risk factors that may play a role during the operation...
October 15, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27752059/klebsiella-pneumoniae-carbapenemase-producing-k-pneumoniae-kpc-kp-in-brain-and-spinal-cord-injury-patients-potential-for-prolonged-colonization
#5
N R Zembower, A Zhu, M Malczynski, C Qi
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To determine the prevalence of brain and spinal cord injury (BSCI) patients among all patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) and to evaluate clinical characteristics and duration of colonization. SETTING: Tertiary care academic medical center. METHODS: Electronic medical records of BSCI patients with KPC-KP from February 2009 to December 2014 were reviewed to determine clinical characteristics...
October 18, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27734449/management-of-crush-syndrome-under-prolonged-field-care
#6
Thomas J Walters, Douglas Powell, Andrew Penny, Ian Stewart, Kevin Chung, Sean Keenan, Stacy Shackelford
No abstract text is available yet for this article.
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/27714538/comparison-of-salvage-total-pharyngolaryngectomy-and-cervical-esophagectomy-between-hypopharyngeal-cancer-and-cervical-esophageal-cancer
#7
Katsushi Takebayashi, Yasuhiro Tsubosa, Tomoyuki Kamijo, Yoshiyuki Iida, Atsushi Imai, Masato Nagaoka, Takashi Kitani, Masahiro Niihara, Eisuke Booka, Ayako Shimada, Masahiro Nakagawa, Tetsuro Onitsuka
BACKGROUND: Total pharyngolaryngectomy and cervical esophagectomy (TPLCE) after chemoradiotherapy remains a challenge because of the high rate of complications and few available data on outcomes and safety. The purpose of this study was to evaluate the clinical significance of salvage TPLCE and to compare treatment outcomes between hypopharyngeal cancer and cervical esophageal cancer. METHODS: Data from 37 consecutive patients who were diagnosed with potentially resectable hypopharyngeal and cervical esophageal cancer after chemoradiotherapy were retrospectively analyzed...
October 6, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27685649/a-field-deployable-reverse-transcription-recombinase-polymerase-amplification-assay-for-rapid-detection-of-the-chikungunya-virus
#8
Pranav Patel, Ahmed Abd El Wahed, Oumar Faye, Pauline Prüger, Marco Kaiser, Sasikanya Thaloengsok, Sukathida Ubol, Anavaj Sakuntabhai, Isabelle Leparc-Goffart, Frank T Hufert, Amadou A Sall, Manfred Weidmann, Matthias Niedrig
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-borne virus currently transmitted in about 60 countries. CHIKV causes acute flu-like symptoms and in many cases prolonged musculoskeletal and joint pain. Detection of the infection is mostly done using RT-RCR or ELISA, which are not suitable for point-of-care diagnosis. METHODOLOGY/PRINCIPAL FINDINGS: In this study, a reverse transcription recombinase polymerase amplification (RT-RPA) assay for the detection of the CHIKV was developed...
September 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27633781/accidental-hypothermia-an-update-the-content-of-this-review-is-endorsed-by-the-international-commission-for-mountain-emergency-medicine-icar-medcom
#9
REVIEW
Peter Paal, Les Gordon, Giacomo Strapazzon, Monika Brodmann Maeder, Gabriel Putzer, Beat Walpoth, Michael Wanscher, Doug Brown, Michael Holzer, Gregor Broessner, Hermann Brugger
BACKGROUND: This paper provides an up-to-date review of the management and outcome of accidental hypothermia patients with and without cardiac arrest. METHODS: The authors reviewed the relevant literature in their specialist field. Summaries were merged, discussed and approved to produce this narrative review. RESULTS: The hospital use of minimally-invasive rewarming for non-arrested, otherwise healthy, patients with primary hypothermia and stable vital signs has the potential to substantially decrease morbidity and mortality for these patients...
September 15, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27602905/analysis-of-injury-patterns-and-roles-of-care-in-us-and-israel-militaries-during-recent-conflicts-two-are-better-than-one
#10
Ben Antebi, Avi Benov, Elizabeth A Mann-Salinas, Tuan D Le, Leopoldo C Cancio, Joseph C Wenke, Haim Paran, Avraham Yitzhak, Bader Tarif, Kirby R Gross, David Dagan, Elon Glassberg
BACKGROUND: As new conflicts emerge and enemies evolve, military medical organizations worldwide must adopt the "lessons learned." In this study, we describe roles of care (ROCs) deployed and injuries sustained by both US and Israeli militaries during recent conflicts. The purpose of this collaborative work is facilitate exchange of medical data among allied forces in order to advance military medicine and facilitate strategic readiness for future military engagements that may involve less predictable situations of evacuation and care, such as prolonged field care...
November 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27556767/prevention-of-pressure-ulcers-in-the-acute-care-setting-new-innovations-and-technologies
#11
Jacquelynn P Tran, Jillian M McLaughlin, Ramon T Li, Linda G Phillips
BACKGROUND: Pressure ulcers (PUs) challenge many in the healthcare field requiring costly and complex care. PUs result from prolonged ischemia and subsequent soft-tissue injury caused by unrelieved pressure over a bony prominence. Proper risk assessment and implementation of prevention strategies for PUs are crucial to providing comprehensive care while reducing healthcare costs. The emphasis has led to the expansion of research in PU prevention technologies in the recent years. The aim of this review is to present an evidence-based summary of some of the new innovations in PU prevention...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27507550/understanding-the-experience-of-miscarriage-in-the-emergency-department
#12
Kate MacWilliams, Jean Hughes, Megan Aston, Simon Field, Faith Wight Moffatt
INTRODUCTION: Up to 20% of pregnancies end in miscarriage, which can be a significant life event for women with psychological implications. Because the only preventative measure for a miscarriage is risk factor modification, the treatment focuses on confirming the miscarriage has occurred and medical management of symptoms. Although women experiencing a miscarriage are frequently directed to seek medical care in emergency departments, the patients are often triaged as nonemergent patients unless they are unstable, which exposes women to potentially prolonged wait times...
August 6, 2016: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/27489630/palliative-care-consults-in-oncology-what-are-we-waiting-for-a-case-report
#13
Elizabeth Kelliher
Palliative care focuses on symptom management and decreased suffering in all aspects of health. Although it has been shown that palliative care improves emotional and clinical outcomes for patients and families, it remains an underutilized specialty particularly in the field of oncology. Involving cancer patients in palliative care can sometimes be confused with the idea of giving up, or losing hope. This is especially true when patients are young. The following case report provides an example of a patient who may have benefited from palliative specialists' involvement early in his disease, potentially sparing him and his family prolonged, physical, and emotional suffering...
2013: SAGE open medical case reports
https://www.readbyqxmd.com/read/27450613/prolonged-field-care-working-group-update
#14
Sean Keenan
No abstract text is available yet for this article.
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/27384595/current-advancement-in-multidisciplinary-treatment-for-resectable-cstage-ii-iii-esophageal-squamous-cell-carcinoma-in-japan
#15
Satoru Matsuda, Hiroya Takeuchi, Hirofumi Kawakubo, Nobutoshi Ando, Yuko Kitagawa
Multidisciplinary treatment comprising surgery, chemotherapy, and radiotherapy for resectable esophageal squamous cell carcinoma (ESCC) is widely used with improved prognosis. Transthoracic esophagectomy (TTE) with extended lymph node (LN) dissection, known as three field LN dissection, has been recommended for ESCC using open thoracotomy or the thoracoscopic approach. The Japan Clinical Oncology Group (JCOG) trial (JCOG1409) is investigating the patients' long term survival using the thoracoscopic approach that has been shown to reduce the incidence of postoperative respiratory complication...
July 6, 2016: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27384275/the-illness-experience-palliative-care-given-the-impossibility-of-healing
#16
Margarida Maria Florêncio Dantas, Maria Cristina Lopes de Almeida Amazonas
This paper presents a reflection about being terminally ill and the various ways that the subject has at its disposal to deal with this event. The objective is to understand the experience of palliation for patients undergoing no therapeutic possibilities of cure. The methodology of this study has the instruments to semi-structured interview, the participant observation and the field diary, and the Descriptive Analysis of Foucault's inspiration how the narratives of the subjects were perceived. The Results of paper there was the possibility of looking at the experience of illness through the eyes of a subject position assumed by the very sick...
June 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27334349/integrated-pain-and-palliative-medicine-model
#17
Sushma Bhatnagar, Mayank Gupta
Pain is one of the most common, distressing and feared symptom among cancer and other patients in need of palliative care. An estimated 25% of cancer patients and 25 million people die in pain each year. Effective pain and symptom management are the core elements of palliative care which aims at reducing suffering and improving quality of life (QOL) throughout the course of illness starting from diagnosis, in sync with curative treatments and at end of life. There is a prevailing shortage of manpower apt to deal with pain and providing cost-effective palliative care and with the rise of cancer, other chronic diseases and explosion of new life-prolonging therapeutic modalities, this 'Patient-pain and palliative physician' discrepancy is only going to increase, more so in developing countries...
July 2016: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/27288065/entering-new-areas-in-known-fields-recombinant-fusion-protein-linking-recombinant-factor-viia-with-recombinant-albumin-rviia-fp-advancing-the-journey
#18
REVIEW
Claude Négrier
The novel fusion protein linking recombinant factor VIIa with recombinant albumin (rVIIa-FP) is designed to extend the half-life of recombinant factor VIIa (rFVIIa) and improve the care of hemophilia A or B patients with inhibitors. Preclinical studies in various animal models have demonstrated markedly improved pharmacokinetic and pharmacodynamic properties, as well as prolonged retention in the joint tissues, of rVIIa-FP compared with a commercially available rFVIIa (NovoSeven®). A phase I study in healthy volunteers - the first study in the PROLONG-7FP program - confirmed that rVIIa-FP has a good tolerability profile in doses of up to 1,000μg/kg and has demonstrated enhanced pharmacodynamic activity relative to rFVIIa...
May 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27258272/blind-rssd-based-indoor-localization-with-confidence-calibration-and-energy-control
#19
Tengyue Zou, Shouying Lin, Shuyuan Li
Indoor localization based on wireless sensor networks (WSNs) is an important field of research with numerous applications, such as elderly care, miner security, and smart buildings. In this paper, we present a localization method based on the received signal strength difference (RSSD) to determine a target on a map with unknown transmission information. To increase the accuracy of localization, we propose a confidence value for each anchor node to indicate its credibility for participating in the estimation...
2016: Sensors
https://www.readbyqxmd.com/read/27106681/royal-australian-and-new-zealand-college-of-psychiatrists-clinical-practice-guidelines-for-the-management-of-schizophrenia-and-related-disorders
#20
Cherrie Galletly, David Castle, Frances Dark, Verity Humberstone, Assen Jablensky, Eóin Killackey, Jayashri Kulkarni, Patrick McGorry, Olav Nielssen, Nga Tran
OBJECTIVES: This guideline provides recommendations for the clinical management of schizophrenia and related disorders for health professionals working in Australia and New Zealand. It aims to encourage all clinicians to adopt best practice principles. The recommendations represent the consensus of a group of Australian and New Zealand experts in the management of schizophrenia and related disorders. This guideline includes the management of ultra-high risk syndromes, first-episode psychoses and prolonged psychoses, including psychoses associated with substance use...
May 2016: Australian and New Zealand Journal of Psychiatry
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