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Non Enzymatic Glycation

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https://www.readbyqxmd.com/read/29133088/fructose-human-serum-albumin-interaction-undergoes-numerous-biophysical-and-biochemical-changes-before-forming-ages-and-aggregates
#1
Asif Zaman, Zarina Arif, Moinuddin, Khursheed Alam
Fructose is a reducing and highly lipogenic sugar that has unique metabolic effects in the liver. Non-enzymatic fructosylation of proteins generates advanced glycation end products (AGEs). Human serum albumin (HSA) may undergo fructosylation vis-à-vis AGEs formation. High fructose consumption may lead to structurally altered and functionally compromised fructosylated-HSA-AGEs, which can cause damage to hepatocytes resulting in hepatic macro- and microvesicular steatosis. In this study, HSA was incubated with varying concentrations of fructose for 10days and the induced changes were studied...
November 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29118444/vanillin-affects-amyloid-aggregation-and-non-enzymatic-glycation-in-human-insulin
#2
Clara Iannuzzi, Margherita Borriello, Gaetano Irace, Marcella Cammarota, Antimo Di Maro, Ivana Sirangelo
Curcumin is known for its anti-inflammatory, antioxidant and anticancer activity, as well as for its ability to interfere with amyloid aggregation and non-enzymatic glycation reaction, that makes it an attractive potential drug. However, curcumin therapeutic use is limited because of its low systemic bioavailability and chemical stability as it undergoes rapid hydrolysis in physiological conditions. Recently, much attention has been paid to the biological properties of curcumin degradation products as potential bioactive molecules...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108337/elevated-hemoglobin-glycation-index-identify-non-diabetic-individuals-at-increased-risk-of-kidney-dysfunction
#3
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Angela Sciacqua, Francesco Andreozzi, Francesco Perticone, Giorgio Sesti
Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has been found to be positively associated with nephropathy in subjects with diabetes. In this cross-sectional study we aimed to evaluate whether higher HGI levels are associated with impaired kidney function also among nondiabetic individuals. The study group comprised 1505 White nondiabetic individuals stratified in quartiles according to HGI levels...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29101895/understanding-the-viscoelastic-behavior-of-arterial-elastin-in-glucose-via-relaxation-time-distribution-spectrum
#4
Yunjie Wang, Haiyue Li, Yanhang Zhang
Elastin is a critical extracellular matrix protein that provides many biological tissues with resilience. In elastic arteries such as aorta, elasticity is crucial for energy storage and transmission of the pulsatile blood flow. As one of the main mechanisms of aging, non-enzymatic glycation can greatly compromise the mechanical properties of the long-lived elastin. In this study, effect of glucose on the viscoelastic behavior of purified porcine aortic elastin was investigated through stress relaxation tests and the corresponding relaxation time distribution spectra...
October 20, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29099805/glypre-in-silico-prediction-of-protein-glycation-sites-by-fusing-multiple-features-and-support-vector-machine
#5
Xiaowei Zhao, Xiaosa Zhao, Lingling Bao, Yonggang Zhang, Jiangyan Dai, Minghao Yin
Glycation is a non-enzymatic process occurring inside or outside the host body by attaching a sugar molecule to a protein or lipid molecule. It is an important form of post-translational modification (PTM), which impairs the function and changes the characteristics of the proteins so that the identification of the glycation sites may provide some useful guidelines to understand various biological functions of proteins. In this study, we proposed an accurate prediction tool, named Glypre, for lysine glycation...
November 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29079528/increased-serotransferrin-and-ceruloplasmin-turnover-in-diet-controlled-patients-with-type-2-diabetes
#6
Makan Golizeh, Kwangwon Lee, Serguei Ilchenko, Abdullah Ösme, James Bena, Rovshan G Sadygov, Sangeeta Kashyap, Takhar Kasumov
Type 2 diabetes mellitus (T2DM) is associated with oxidative stress and perturbed iron metabolism. Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Non-enzymatic glycation and oxidative modification of plasma proteins are known to occur under hyperglycemia and oxidative stress. In this study, shotgun proteomics and (2)H2O-based metabolic labeling were used to characterize post-translational modifications and assess the kinetics of Trf and Cp in T2DM patients and matched controls in vivo...
October 25, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29077935/glycation-reduces-the-stability-of-apoai-and-increases-hdl-dysfunction-in-diet-controlled-type-2-diabetes
#7
Sangeeta R Kashyap, Abdullah Osme, Serguei Ilchenko, Makan Golizeh, Kwangwon Lee, Shuhui Wang, James Bena, Stephen F Previs, Jonathan D Smith, Takhar Kasumov
Context: Hyperglycemia plays a key role in the pathogenesis of cardiovascular complications of diabetes. T2DM is associated with high density lipoprotein (HDL) dysfunction and increased degradation of ApoAI. The mechanism(s) of these changes are largely unknown. Objective: To study the role of hyperglycemia-induced glycation on ApoAI kinetics and stability in patients with diet-controlled T2DM. Design: 2H2O-metabolic labeling approach was used to study ApoAI turnover in patients with diet-controlled T2DM (N= 9 (5F), 59...
October 25, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29073574/effects-of-non-enzymatic-glycation-on-the-micro-and-nano-mechanics-of-articular-cartilage
#8
Parisa R Moshtagh, Nicoline M Korthagen, Mattie H P van Rijen, Rene M Castelein, Amir A Zadpoor, Harrie Weinans
The mechanical properties of articular cartilage depend on the quality of its matrix, which consists of collagens and glycosaminoglycans (GAGs). The accumulation of advanced glycation end products (AGEs) can greatly affect the mechanics of cartilage. In the current study, we simulated the accumulation of AGEs by using L-threose to cross-link collagen molecules in the cartilage matrix (in vitro). The resulting changes in the mechanical properties (stiffness) of cartilage are then measured both at the micrometer-scale (using micro-indenter) and nanometer-scale (using indentation-type atomic force microscopy)...
September 30, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29071030/diabetic-retinopathy-and-laser-therapy-in-rats-a-protein-protein-interaction-network-analysis
#9
Akram Safaei, Mostafa Rezaei Tavirani, Mona Zamanian Azodi, Alireza Lashay, Seyed Farzad Mohammadi, Mohamad Ghasemi Broumand, Ali Asghar Peyvandi, Farshad Okhovatian, Hassan Peyvandi, Mohammad Rostami Nejad
Introduction: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes which can cause vision loss or blindness ultimately. Non enzymatic glycation of proteins leads to advanced glycation end products (AGEs) in DR. Since laser therapy is a well-established method, in this study, protein-protein interaction (PPI) network is applied for protein targets in DR disease in rats treated by laser. Methods: In this study, we focused on articles that investigated and compared the proteome profiles of DR rats with healthy control and also DR rats before and after laser therapy...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29057494/a-decrease-in-serum-1-5-anhydroglucitol-levels-is-associated-with-the-presence-of-a-first-degree-family-history-of-diabetes-in-a-chinese-population-with-normal-glucose-tolerance
#10
X Hu, X He, X Ma, H Su, L Ying, J Peng, Y Wang, Y Bao, J Zhou, W Jia
AIM: This study aimed to investigate alterations in HbA1c , glycated albumin (GA) and 1,5-anhydroglucitol (1,5-AG) in Chinese first-degree relatives of individuals with diabetes (FDR) in pursuit of an index for early screening of glucose metabolism disturbance. METHODS: A total of 467 participants (age range: 20-78 years) with normal weight and normal glucose tolerance, as determined by a 75-g oral glucose tolerance test, were enrolled. HbA1c was measured using high-pressure liquid chromatography...
October 23, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29043349/comparative-suppressing-effects-of-black-and-green-teas-on-the-formation-of-advanced-glycation-end-products-ages-and-age-induced-oxidative-stress
#11
P Ramlagan, P Rondeau, C Planesse, V S Neergheen-Bhujun, E Bourdon, T Bahorun
This study aimed at investigating and comparing the anti-diabetic potential of black and green teas. Biochemical analyses indicate higher antioxidant potency, significantly correlated with the phytochemicals present, in green teas compared to black teas. Both extracts afforded a similar level of protection to erythrocytes against peroxyl radical-induced lysis. Non-cytotoxic concentration of green and black tea extracts significantly reduced the reactive oxygen species (ROS) production (P < 0.01), lowered the oxidation of proteins (P < 0...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/29036767/the-role-of-glycation-in-the-pathogenesis-of-aging-and-its-prevention-through-herbal-products-and-physical-exercise
#12
Chan-Sik Kim, Sok Park, Junghyun Kim
PURPOSE: Advanced glycation end products (AGEs) are non-enzymatic modifications of proteins or lipids after exposure to sugars. In this review, the glycation process and AGEs are introduced, and the harmful effects of AGEs in the aging process are discussed. METHODS: Results from human and animal studies examining the mechanisms and effects of AGEs are considered. In addition, publications addressing means to attenuate glycation stress through AGE inhibitors or physical exercise are reviewed...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28993156/association-between-hemoglobin-glycation-index-and-hepatic-steatosis-in-non-diabetic-individuals
#13
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Francesco Andreozzi, Angela Sciacqua, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti
AIMS: Hemoglobin glycation index (HGI), which is the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with diabetic complications. Herein we investigated whether HGI is associated with hepatic steatosis and related biomarkers in subjects without diabetes. METHODS: 1120 White individuals without diabetes were stratified in quartiles according to HGI levels...
October 6, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28966557/what-is-the-role-of-systemic-conditions-and-options-for-manipulation-of-bone-formation-and-bone-resorption-in-rotator-cuff-tendon-healing-and-repair
#14
Simon Lee, Jonathan Gumucio, Christopher Mendias, Asheesh Bedi
Rotator cuff pathology is a significant cause of shoulder pain. Operative repair of rotator cuff is an established standard of care for these patient, however, failure of the procedure is common. Systemic conditions such as diabetes mellitus, hypocholesteremia, thyroid disease, and smoking significantly affect the outcomes of rotator cuff repair and have significant implications for the management of these patients. Diabetes mellitus has been proposed to damage tendons through non-enzymatic glycosylation of collagen with advanced glycation end product formation and impaired microcirculation...
September 2017: Techniques in Shoulder & Elbow Surgery
https://www.readbyqxmd.com/read/28939611/concomitant-loss-of-the-glyoxalase-system-and-glycolysis-makes-the-uncultured-pathogen-candidatus-liberibacter-asiaticus-an-energy-scavenger
#15
Mukesh Jain, Alejandra Munoz-Bodnar, Dean W Gabriel
Methylglyoxal (MG) is a cytotoxic, non-enzymatic byproduct of glycolysis that readily glycates proteins and DNA, resulting in carbonyl stress. Glyoxalase I and II (GloA and GloB) sequentially convert MG into D-lactic acid using glutathione (GSH) as a cofactor. The glyoxalase system is essential for the mitigation of MG-induced carbonyl stress, preventing subsequent cell death, and recycling GSH for maintenance of cellular redox poise. All pathogenic Liberibacters identified to date are uncultured, including "Candidatus Liberibacter asiaticus", a psyllid endosymbiont and causal agent of the severely damaging citrus disease 'huanglongbing'...
September 22, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28901784/impact-of-maillard-reaction-products-on-nutrition-and-health-current-knowledge-and-need-to-understand-their-fate-in-the-human-digestive-system
#16
Nesreen ALjahdali, Franck Carbonero
The Maillard Reaction (MR) is a non-enzymatic chemical reaction which results in the linkage between the amino group of amino acids and the carbonyl group of reduced sugars. MR products (MRPs) are common components of processed foods, mainly as a result of heating, especially in the Western diet. MRPs are classified as into three stages: initial, intermediate, and final stages, indicative of increased complexity and size, incurring different flavor, aroma, and texture. MRPs presence is known to reduce the nutritional quality of foods, particularly by reducing protein digestibility...
September 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28886871/daf-in-diabetic-patients-is-subject-to-glycation-inactivation-at-its-active-site-residues
#17
Rudolf Flückiger, Enzo Cocuzzi, Ram H Nagaraj, Menachem Shoham, Timothy S Kern, M Edward Medof
Decay accelerating factor (DAF or CD55) is a cell associated C3 and C5 convertase regulator originally described in terms of protection of self-cells from systemic complement but now known to modulate adaptive T cell responses. It is expressed on all cell types. We investigated whether nonenzymatic glycation could impair its function and potentially be relevant to complications of diabetes mellitus and other conditions that result in nonenzymatic glycation including cancer, Alzheimer's disease, and aging. Immunoblots of affinity-purified DAF from erythrocytes of patients with diabetes showed pentosidine, glyoxal-AGEs, carboxymethyllysine, and argpyrimidine...
September 5, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28843667/the-specific-localization-of-advanced-glycation-end-products-ages-in-rat-pancreatic-islets
#18
Yuta Morioka, Kiyoshi Teshigawara, Yasuko Tomono, Dengli Wang, Yasuhisa Izushi, Hidenori Wake, Keyue Liu, Hideo Kohka Takahashi, Shuji Mori, Masahiro Nishibori
Advanced glycation end-products (AGEs) are produced by non-enzymatic glycation between protein and reducing sugar such as glucose. Although glyceraldehyde-derived AGEs (Glycer-AGEs), one of the AGEs subspecies, have been reported to be involved in the pathogenesis of various age-relating diseases such as diabetes mellitus or arteriosclerosis, little is known about the pathological and physiological mechanism of AGEs in vivo. In present study, we produced 4 kinds of polyclonal antibodies against AGEs subspecies and investigated the localization of AGEs-modified proteins in rat peripheral tissues, making use of these antibodies...
August 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28820963/ketone-body-acetoacetate-buffers-methylglyoxal-via-a-non-enzymatic-conversion-during-diabetic-and-dietary-ketosis
#19
Trine Salomón, Christian Sibbersen, Jakob Hansen, Dieter Britz, Mads Vandsted Svart, Thomas Schmidt Voss, Niels Møller, Niels Gregersen, Karl Anker Jørgensen, Johan Palmfeldt, Thomas Bjørnskov Poulsen, Mogens Johannsen
The α-oxoaldehyde methylglyoxal is a ubiquitous and highly reactive metabolite known to be involved in aging- and diabetes-related diseases. If not detoxified by the endogenous glyoxalase system, it exerts its detrimental effects primarily by reacting with biopolymers such as DNA and proteins. We now demonstrate that during ketosis, another metabolic route is operative via direct non-enzymatic aldol reaction between methylglyoxal and the ketone body acetoacetate, leading to 3-hydroxyhexane-2,5-dione. This novel metabolite is present at a concentration of 10%-20% of the methylglyoxal level in the blood of insulin-starved patients...
August 17, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28812216/an-overview-of-in-vitro-and-in-vivo-glycation-of-albumin-a-potential-disease-marker-in-diabetes-mellitus
#20
REVIEW
Km Neelofar, Jamal Ahmad
Non-enzymatic glycation of macromolecules, especially proteins leading to their oxidation is increased in diabetes mellitus due to hyperglycaemia and play an important role in associated complications of the disease. Protein glycation mostly occurs in intra chain lysine residues resulting in the formation of early stage Amadori products which are finally converted to advance glycation end products (AGEs). This review deals with the structural studies of in vitro and in vivo glycated human serum albumin (HSA)...
August 15, 2017: Glycoconjugate Journal
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