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Non Enzymatic Glycation

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https://www.readbyqxmd.com/read/28632197/toxic-age-tage-theory-for-the-pathophysiology-of-the-onset-progression-of-nafld-and-ald
#1
REVIEW
Masayoshi Takeuchi, Jun-Ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi
Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are among the most common causes of chronic liver diseases in the westernized world. NAFLD and ALD are frequently accompanied by extrahepatic complications, including hepatocellular carcinoma and cardiovascular diseases, which have a negative impact on patient survival. The chronic ingestion of an excessive daily diet containing sugar/high-fructose corn syrup increases the level of the fructose/glucose metabolite, glyceraldehyde (GA), while the chronic consumption of an excessive number of alcoholic beverages increases the level of the alcohol metabolite, acetaldehyde (AA) in the liver...
June 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28586301/definition-of-the-upper-reference-limit-of-glycated-albumin-in-blood-donors-from-italy
#2
Chiara Bellia, Martina Zaninotto, Chiara Cosma, Luisa Agnello, Bruna Lo Sasso, Giulia Bivona, Mario Plebani, Marcello Ciaccio
BACKGROUND: Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. METHODS: The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany)...
June 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28573980/3d-porous-collagen-scaffolds-reinforced-by-glycation-with-ribose-for-tissue-engineering-application
#3
Natalia Gostynska, Gopal Krishnakumar, Elisabetta Campodoni, Silvia Panseri, Monica Montesi, Simone Sprio, Elizaveta Kon, Maurilio Marcacci, Anna Tampieri, Monica Sandri
In this study ribose was proposed as a promising, non-toxic, low-cost crosslinker to enhance the structural integrity and stiffness of type I collagen matrices. The main objective was to determine optimal conditions of glycation by ribose to fabricate 3D porous collagen scaffolds and to verify their effectiveness for use as scaffolds for cartilage tissue engineering (TE), by physicochemical and biological characterization. Two different crosslinking strategies were investigated including variety in the amount of ribose and the time of reaction: pre-crosslinking (PRE) and post-crosslinking (POST)...
June 2, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28551552/standardized-mori-ramulus-extract-improves-insulin-secretion-and-insulin-sensitivity-in-c57blks-j-db-db-mice-and-ins-1-cells
#4
Soo-Yeon Park, Bora Jin, Jae-Ho Shin, Sirichai Adisakwattana, Oran Kwon
Abnormalities in the hyperbolic relationship between insulin sensitivity and insulin secretion may cause oxidative stress and non-enzymatic glycation, resulting in an increased risk of type 2 diabetes. Here, we performed a 14-week study to investigate the effects of ethanolic extract of Mori ramulus (MRE; 0, 800, and 1600mg/kg body weight) and its signature component oxyresveratrol (OXY; 800mg/kg body weight) on β-cell dysfunction and insulin resistance in C57BLKS/J db/db mice fed with a high-fat diet. Compared with the diabetic control group, the high-dose MRE group showed a significant decrease in fasting blood glucose (p=0...
May 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28546110/hypoxia-driven-glycation-mechanisms-and-therapeutic-opportunities
#5
REVIEW
Mohammad Imran Khan, Suvasmita Rath, Vaqar Mustafa Adhami, Hasan Mukhtar
Tumor masses are deprived of oxygen and characterized by enhanced glucose uptake followed by glycolysis. Elevated glucose levels induce non-enzymatic glycosylation or glycation of proteins which leads to accumulation of advanced glycation end products (AGE). These AGE molecules bind to their respective receptors called the receptor for advanced glycation end products (RAGE) and initiate several aberrant signaling pathways leading to onset of diseases such as diabetes, Alzheimer's, atherosclerosis, heart failure and cancer...
May 22, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28529569/advanced-glycation-end-products-influence-oral-cancer-cell-survival-via-bcl-xl-and-nrf-2-regulation-in-vitro
#6
Shun-Yao Ko, Hshin-An Ko, Tzong-Ming Shieh, Tzong-Cherng Chi, Hong-I Chen, Yi-Ting Chen, Ya-Hui Yu, Shu-Han Yang, Shu-Shing Chang
An irreversible non-enzymatic reaction between carbohydrates and proteins results in the formation of advanced glycation end products (AGEs). AGEs have been demonstrated to be a risk factor of complications in patients with diabetes mellitus (DM). Previous studies have suggested that patients with DM exhibit a higher rate of metastasis of oral cancer and a lower cancer-associated survival rate. The receptor for AGEs (RAGE) has been associated with angiogenesis and an increase in cancer malignancy. Previous studies have suggested that AGE-RAGE regulates cell migration via extracellular signal-regulated kinase (ERK) phosphorylation...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521879/a-quick-simple-method-for-detecting-circulating-fluorescent-advanced-glycation-end-products-correlation-with-in-vitro-and-in-vivo-non-enzymatic-glycation
#7
Marika Villa, Mariacristina Parravano, Arianna Micheli, Lucia Gaddini, Andrea Matteucci, Cinzia Mallozzi, Francesco Facchiano, Fiorella Malchiodi-Albedi, Flavia Pricci
OBJECTIVE: Advanced glycation end-products (AGEs) constitute a highly heterogeneous family of compounds, relevant in the pathogenesis of diabetic complications, which could represent efficient biomarkers of disease progression and drug response. Unfortunately, due to their chemical heterogeneity, no method has been validated to faithfully monitor their levels in the course of the disease. In this study, we refine a procedure to quantitatively analyze fluorescent AGEs (fAGEs), a subset considered remarkably representative of the entire AGE family, and measure them in in vitro glycated BSA (gBSA) and in plasma and vitreous of diabetic rats, for testing its use to possibly quantify circulating AGEs in patients, as markers of metabolic control...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28520799/nonenzymatic-glycosylation-of-human-serum-albumin-and-its-effect-on-antibodies-profile-in-patients-with-diabetes-mellitus
#8
Alok Raghav, Jamal Ahmad, Khursheed Alam
BACKGROUND: Albumin glycation and subsequent formation of advanced glycation end products (AGEs) correlate with diabetes and associated complications. METHODS: Human Serum Albumin (HSA) was modified with D-glucose for a 40 day period under sterile conditions at 37°C. Modified samples along with native HSA (unmodified) were analyzed for structural modifications by UV and fluorescence, FTIR, Liquid chromatography mass spectrometry (LCMS) and X-ray crystallography...
2017: PloS One
https://www.readbyqxmd.com/read/28515343/kidney-heart-and-brain-three-organs-targeted-by-ageing-and-glycation
#9
REVIEW
Marie Frimat, Maité Daroux, Rachel Litke, Rémi Nevière, Frédéric J Tessier, Eric Boulanger
Advanced glycation end-product (AGE) is the generic term for a heterogeneous group of derivatives arising from a non-enzymatic reaction between reducing sugars and proteins. In recent years, evidence has accumulated that incriminates AGEs in pathogenic processes associated with both chronic hyperglycaemia and age-related diseases. Regardless of their exogenous or endogenous origin, the accumulation of AGEs and their derivatives could promote accelerated ageing by leading to protein modifications and activating several inflammatory signalling pathways via AGE-specific receptors...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28501572/quercetin-inhibited-epithelial-mesenchymal-transition-in-diabetic-rats-high-glucose-cultured-lens-and-sra01-04-cells-through-transforming-growth-factor-%C3%AE-2-phosphoinositide-3-kinase-akt-pathway
#10
Lei Du, Meng Hao, Chengcheng Li, Wenya Wu, Wenwen Wang, Zhongxuan Ma, Tingting Yang, Nan Zhang, Adelusi Temitope Isaac, Xia Zhu, Ying Sun, Qian Lu, Xiaoxing Yin
Diabetic cataract (DC), an identified life-threatening secondary complication of diabetes mellitus, has proven to be a dilemma because of its multifactorial caused and progression. An increasing number of studies have shown that in addition to the maillard reaction, enhanced polyol pathway, and oxidative insults, epithelial mesenchymal transition (EMT) is related to the prevalence of DC. Quercetin, a classic flavonoid with multiple pharmacological effects has been reported to possess therapeutic efficacy in the management and treatment of this disease...
May 10, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28494267/advanced-glycation-products-levels-and-mechanical-properties-of-vaginal-tissue-in-pregnancy
#11
Homayemem K Weli, Riaz Akhtar, Zhuo Chang, Wen-Wu Li, Jason Cooper, Ying Yang
OBJECTIVES: Non-enzymatic glycation is closely associated with altered mechanical properties of connective tissue. Pregnancy, marked with high levels of female hormones, confers unique alteration to the mechanical properties of pelvic connective tissues in order to meet their physiological demands. However, there are few studies on glycation content and its influence on the mechanical properties of pelvic connective tissues during pregnancy. We hypothesise that the glycation content in pelvic tissues will change with a corresponding alteration in their mechanical properties, and that these changes are influenced by hormone levels...
April 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28487198/bimolecular-interaction-of-argpyrimidine-a-maillard-reaction-product-in-in-vitro-non-enzymatic-protein-glycation-model-and-its-potential-role-as-an-antiglycating-agent
#12
Abhishek Bhattacherjee, Kaliprasanna Dhara, Abhay Sankar Chakraborti
Non- enzymatic glycation, also known as Maillard reaction, is one of the most important and investigated reactions in biochemistry. Maillard reaction products (MRPs) like protein-derived advanced glycation end products (AGEs) are often referred to cause pathophysiological complications in human systems. On contrary, several MRPs are exogenously used as antioxidant, antimicrobial and flavouring agents. In the preset study, we have shown that argpyrimidine, a well-established AGE, interacts with bovine serum albumin (BSA) and glucose individually in standard BSA-glucose model system and successfully inhibits glycation of the protein...
May 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28480697/sensitive-detection-of-glycated-albumin-in-human-serum-albumin-using-electrochemiluminescence
#13
Yuki Inoue, Mikako Inoue, Masato Saito, Hiroyuki Yoshikawa, Eiichi Tamiya
Monitoring of blood glucose content is vital for diabetes patients. The conventional widely used method involves an invasive procedure for blood sampling. In addition, blood glucose measured by this way is affected by immediate food consumption and it does not show accurate baseline blood glucose measurement. Thus, monitoring blood glucose by a noninvasive method that accurately reflects baseline blood glucose content is important. Glycated albumin (GA), a biomarker for diabetes indicating the average blood glucose over 2 weeks, can be used for semilong-term blood glucose monitoring...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28475116/dicarbonyls-and-advanced-glycation-end-products-in-the-development-of-diabetic-complications-and-targets-for-intervention
#14
REVIEW
Sebastian Brings, Thomas Fleming, Marc Freichel, Martina U Muckenthaler, Stephan Herzig, Peter P Nawroth
Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented...
May 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28455790/advanced-glycation-end-products-attenuate-the-function-of-tumor-necrosis-factor-like-weak-inducer-of-apoptosis-to-regulate-the-inflammatory-response
#15
Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Keyue Liu, Kiyoshi Teshigawara, Hideo Takahashi, Masahiro Nishibori, Shuji Mori
Advanced glycation end products (AGEs) are formed from the non-enzymatic glycation reaction of reducing sugars or their metabolites with the free amino groups of several biomolecules and are known to play pathophysiological roles in various inflammatory diseases. In an earlier study, it was suggested that tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has a unique role to regulate the tumor necrosis factor α (TNFα)-induced inflammatory response. In this study, we investigated the effect of the AGEs-TWEAK interaction on proinflammatory signaling responses in endothelial cells and the influence of AGEs on the cellular function of TWEAK in the inflammatory process...
April 28, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28452927/the-metabolic-memory-theory-and-the-early-treatment-of-hyperglycemia-in-prevention-of-diabetic-complications
#16
REVIEW
Roberto Testa, Anna Rita Bonfigli, Francesco Prattichizzo, Lucia La Sala, Valeria De Nigris, Antonio Ceriello
Several epidemiological and prospective studies suggest that an early intensive control of hyperglycaemia is able to decrease the risk of diabetic micro- and macro-vascular complications. A growing body of experimental evidence supports the concept that the risk for diabetes complications may be linked to oxidative stress, non-enzymatic glycation of proteins, epigenetic changes, and chronic inflammation, laying the foundation for the "metabolic memory" theory. From a clinical point of view, this theory supports the need for a very early aggressive treatment, with the goal of normalizing metabolic control as soon as possible...
April 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28426788/association-between-hemoglobin-glycation-index-with-insulin-resistance-and-carotid-atherosclerosis-in-non-diabetic-individuals
#17
Maria Adelaide Marini, Teresa Vanessa Fiorentino, Elena Succurro, Elisabetta Pedace, Francesco Andreozzi, Angela Sciacqua, Francesco Perticone, Giorgio Sesti
Hemoglobin glycation index (HGI), defined as the difference between the observed HbA1c value and the value of HbA1c predicted from plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with micro- and macro-vascular complications in subjects with type 2 diabetes. To investigate the pathophysiological abnormalities responsible for the increased cardiovascular risk of patients with higher HGI, we evaluated the association of HGI with cardio-metabolic characteristics in nondiabetic offspring of type 2 diabetic individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28412196/non-enzymatic-glycation-enhances-human-serum-albumin-binding-capacity-to-sodium-fluorescein-at-room-temperature-a-spectroscopic-analysis
#18
Sadaf Fatima, Tamanna Anwar, Nabeel Ahmad, Asimul Islam, Priyankar Sen
BACKGROUND: Sodium fluorescein (SF) is a fluorescent tracer dye used extensively in diagnostic tools in the field of Ophthalmology, particularly in intravenous fluorescein angiography (IVFA). The binding of SF to human serum albumin (HSA) has been predicted by molecular docking and investigated by circular dichroism (CD) and fluorescence spectroscopy with or without glycation at temperatures 296, 301, and 310K. METHODS: The binding parameters were calculated by quenching of emission spectrum of a constant concentration of SF (2μmol/l) at 513nm against increasing concentrations of glycated or unmodified HSA as quencher starting from stoichiometry ratio of 1:1...
April 12, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28409435/aldo-ketoreductase-1-akr1-improves-seed-longevity-in-tobacco-and-rice-by-detoxifying-reactive-cytotoxic-compounds-generated-during-ageing
#19
Nisarga Kodadinne Narayana, Ramu S Vemanna, Babitha Kodekallu Chandrashekar, Hanumantha Rao, Amaranatha Reddy Vennapusa, Ashwini Narasimaha, Udayakumar Makarla, Mohan Raju Basavaiah
BACKGROUND: Maintenance of seed viability is an important factor for seedling vigour and plant establishment. Lipid peroxidation mediated reactive carbonyl compounds (RCC's) and non-enzymatic modifications of proteins through Maillard and Amadori products reduce seed viability and seedling vigour. RESULTS: In this study, the relevance of RCCs on genotypic variation in rice seed viability and overexpression of an aldo-ketoreductase (AKR1) enzyme that detoxify cytotoxic compounds to improve seed viability and vigour was studied...
December 2017: Rice
https://www.readbyqxmd.com/read/28405811/advanced-glycation-end-products-as-a-biomarker-for-incisional-hernia
#20
J J Harlaar, H H Eker, K A Vakalopoulos, M C Cabezas, A C van der Ham, W W Vrijland, J Jeekel, J F Lange
BACKGROUND: Incisional hernia is one of the most frequent complications after abdominal surgery, with incidences up to 30%. A reliable biomarker for the prediction of this complication is lacking. Advanced glycosylation end products (AGEs), also known as non-enzymatic collagen crosslinks, are correlated with aging, smoking, hyperglycemia, hyperlipidemia and oxidative stress. In this study the accumulation of AGEs and the relation between AGEs and incisional hernia were investigated. MATERIALS AND METHODS: In an exploratory case-control study, 23 patients with incisional hernia after midline incision were compared with 17 patients without clinical or radiological signs of incisional hernia after midline incision, AGEs were measured using a Skin Auto Fluorescence (SAF)-reader...
April 12, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
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