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Non Enzymatic Glycation

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https://www.readbyqxmd.com/read/27903233/evaluation-of-structure-chaperone-activity-and-allergenicity-of-reduced-glycated-adduct-of-bovine-%C3%AE-casein
#1
Reza Yousefi, Leila Ferdowsi, Zohreh Tavaf, Tanaz Sadeghian, Ali Mohammad Tamaddon, Mozhgan Moghtaderi, Zahra Pourpak
Milk has a potent reducing environment with an important quantity of sugar levels. In the current study β-casein was glycated in the presence of D-glucose and sodium cyanoborohydride as a reducing agent. Then, the reduced glucitol adduct of β-casein was used for the structural and functional analyses using different spectroscopic techniques. The results of fluorescence and far ultraviolet circular dichroism assessments suggest important structural alteration upon non-enzymatic glycation of β-casein. In addition, the chaperone activity, micellization properties and antioxidant activity of this protein were altered upon glucose modification...
November 21, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27827482/glycation-induces-conformational-changes-in-the-amyloid-%C3%AE-peptide-and-enhances-its-aggregation-propensity-molecular-insights
#2
Asis K Jana, Kedar B Batkulwar, Mahesh J Kulkarni, Neelanjana Sengupta
The cytotoxicity of the amyloid beta (Aβ) peptide, implicated in the pathogenesis of Alzheimer's disease (AD), can be enhanced by its post-translational glycation, a series of non-enzymatic reactions with reducing sugars and reactive dicarbonyls. However, little is known about the underlying mechanisms that potentially enhance the cytotoxicity of the advanced glycation modified Aβ. In this work, fully atomistic molecular dynamics (MD) simulations are exploited to obtain direct molecular insights into the process of early Aβ self-assembly in the presence and absence of glycated lysine residues...
November 9, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27816946/advanced-glycation-end-products-mediated-cellular-and-molecular-events-in-the-pathology-of-diabetic-nephropathy
#3
Anil Kumar Pasupulati, P Swathi Chitra, G Bhanuprakash Reddy
Diabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetic patients and a leading cause of end-stage renal disease (ESRD). Degenerative changes such as glomerular hypertrophy, hyperfiltration, widening of basement membranes, tubulointerstitial fibrosis, glomerulosclerosis and podocytopathy manifest in various degrees of proteinuria in DN. One of the key mechanisms implicated in the pathogenesis of DN is non-enzymatic glycation (NEG). NEG is the irreversible attachment of reducing sugars onto free amino groups of proteins by a series of events, which include the formation of Schiff's base and an Amadori product to yield advanced glycation end products (AGEs)...
December 1, 2016: Biomolecular Concepts
https://www.readbyqxmd.com/read/27816054/increased-age-rage-ratio-in-idiopathic-pulmonary-fibrosis
#4
Carlos Machahua, Ana Montes-Worboys, Roger Llatjos, Ignacio Escobar, Jordi Dorca, Maria Molina-Molina, Vanesa Vicens-Zygmunt
BACKGROUND: The abnormal epithelial-mesenchymal restorative capacity in idiopathic pulmonary fibrosis (IPF) has been recently associated with an accelerated aging process as a key point for the altered wound healing. The advanced glycation end-products (AGEs) are the consequence of non-enzymatic reactions between lipid and protein with several oxidants in the aging process. The receptor for AGEs (RAGEs) has been implicated in the lung fibrotic process and the alveolar homeostasis. However, this AGE-RAGE aging pathway has been under-explored in IPF...
November 5, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27796444/effects-of-raloxifene-and-alendronate-on-non-enzymatic-collagen-cross-links-and-bone-strength-in-ovariectomized-rabbits-in-sequential-treatments-after-daily-human-parathyroid-hormone-1-34-administration
#5
S Kimura, M Saito, Y Kida, A Seki, Y Isaka, K Marumo
: This study investigated the effects of raloxifene and alendronate to follow parathyroid hormone (PTH) on bone collagen and biomechanical properties in ovariectomized rabbits. Sequential treatments of raloxifene and alendronate after hPTH(1-34) treatment improved biomechanical properties with and without bone collagen improvement, respectively. INTRODUCTION: The standard sequential treatment to follow human parathyroid hormone (hPTH) (1-34) therapy for osteoporosis has yet to be determined...
October 29, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27787813/the-influence-of-fluorine-on-the-disturbances-of-homeostasis-in-the-central-nervous-system
#6
REVIEW
K Dec, A Łukomska, D Maciejewska, K Jakubczyk, I Baranowska-Bosiacka, D Chlubek, A Wąsik, I Gutowska
Fluorides occur naturally in the environment, the daily exposure of human organism to fluorine mainly depends on the intake of this element with drinking water and it is connected with the geographical region. In some countries, we can observe the endemic fluorosis-the damage of hard and soft tissues caused by the excessive intake of fluorine. Recent studies showed that fluorine is toxic to the central nervous system (CNS). There are several known mechanisms which lead to structural brain damage caused by the excessive intake of fluorine...
October 27, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27774900/phytochemicals-against-advanced-glycation-end-products-ages-and-the-receptor-system
#7
Sho-Ichi Yamagishi, Takanori Matsui, Yuji Ishibashi, Fumiyuki Isami, Yumi Abe, Tatsuya Sakaguchi, Yuichiro Higashimoto
Reducing sugars can react non-enzymatically with amino groups of proteins and lipids to form irreversibly cross-linked macroprotein derivatives called as advanced glycation end products (AGEs). Cross-linking modification of extracellular matrix proteins by AGEs deteriorate their tertiary structural integrity and function, contributing to aging-related organ damage and diabetes-associated complications, such as cardiovascular disease (CVD). Moreover, engagement of receptor for AGEs, RAGE with the ligands evoke oxidative stress generation and inflammatory, thrombotic and fibrotic reactions in various kinds of tissues, further exacerbating the deleterious effects of AGEs on multiple organ systems...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27751506/advanced-glycation-end-products-an-emerging-biomarker-for-adverse-outcome-in-patients-with-peripheral-artery-disease
#8
Lisanne C de Vos, Joop D Lefrandt, Robin P F Dullaart, Clark J Zeebregts, Andries J Smit
Patients with peripheral artery disease (PAD) suffer from widespread atherosclerosis. Partly due to the growing awareness of cardiovascular disease, the incidence of PAD has increased considerably during the past decade. It is anticipated that algorithms to identify high risk patients for cardiovascular events require being updated, making use of novel biomarkers. Advanced glycation end products (AGEs) are moieties formed non-enzymatically on long-lived proteins under influence of glycemic and oxidative stress reactions...
October 6, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27749032/ameliorating-effects-of-green-synthesized-silver-nanoparticles-on-glycated-end-product-induced-ros-production-and-cellular-toxicity-in-osteogenic-saos-2-cells
#9
Sarbani Ashe, Debasis Nayak, Manisha Kumari, Bismita Nayak
Advanced glycation end-products (AGEs) resulting from non-enzymatic glycation are one of the major factors involved in diabetes and its secondary complications and diseases. This necessitates our urge to discover new compounds that may be used as potential AGEs inhibitors without affecting the normal structure and function of biomolecules. In the present study, we investigated the inhibitory effects of AgNP (silver nanoparticles) on AGEs formation as well as their inhibitory effects on glycation mediated cell toxicity via ROS production and DNA damage...
October 17, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27738860/mangostanaxanthones-iii-and-iv-advanced-glycation-end-product-inhibitors-from-the-pericarp-of-garcinia-mangostana
#10
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer's disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to inhibit AGE formation...
October 13, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27719648/therapeutic-interventions-for-advanced-glycation-end-products-and-its-receptor-mediated-cardiovascular-disease
#11
Kailash Prasad, Shuchita Tiwari
Advanced glycation end products (AGEs) are heterogeneous group of molecules formed from non-enzymatic reaction of reducing sugars with amino group of proteins, lipids, and nucleic acid. Interaction of AGEs with its cell-bound receptor (RAGE) results in generation of oxygen radicals, nuclear factor kappa-β, pro-inflammatory cytokines and cell adhesion molecules, and is involved in the pathophysiology of cardiovascular diseases (CVD). Circulating soluble forms of RAGE (sRAGE) and endo-secretory RAGE (esRAGE) compete with RAGE for ligand binding and function as a decoy...
October 6, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27704837/ages-rage-related-neurodegeneration-daf-16-as-a-mediator-insulin-as-an-ameliorant-and-c-elegans-as-an-expedient-research-model
#12
Adi Pinkas, Michael Aschner
Advanced glycation end-products (AGEs) are non-enzymatically glycated proteins, lipids and nucleic acids. These compounds both originate exogenously and are formed endogenously, and are associated, along with one of their receptors - RAGE, with a variety of pathologies and neurodegeneration. Some of their deleterious effects include affecting insulin signaling and FOXO-related pathways in both receptor-dependent and -independent manner. A potential ameliorating agent for these effects is insulin, which is being studied in several in vivo and in vitro models; one of these models is C...
October 5, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27704396/advanced-glycation-end-products-diabetes-and-bone-strength
#13
REVIEW
Masahiro Yamamoto, Toshitsugu Sugimoto
Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), which are diverse compounds generated via a non-enzymatic reaction between reducing sugars and amine residues, physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers. On the other hand, these compounds biologically act as agonists for these receptors for AGEs (RAGE) and suppress bone metabolism...
December 2016: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/27695694/glycation-in-demetalated-superoxide-dismutase-1-prevents-amyloid-aggregation-and-produces-cytotoxic-ages-adducts
#14
Ivana Sirangelo, Filomena M Vella, Gaetano Irace, Giuseppe Manco, Clara Iannuzzi
Superoxide dismutase 1 (SOD1) has been implicated with familial amyotrophic lateral sclerosis (fALS) through accumulation of protein amyloid aggregates in motor neurons of patients. Amyloid aggregates and protein inclusions are a common pathological feature of many neurological disorders in which protein aggregation seems to be directly related to neurotoxicity. Although, extensive studies performed on the aggregation process of several amyloidogenic proteins in vitro allowed the identification of many physiological factors involved, the molecular mechanisms underlying the formation of amyloid aggregates in vivo and in pathological conditions are still poorly understood...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27684203/how-to-study-basement-membrane-stiffness-as-a-biophysical-trigger-in-prostate-cancer-and-other-age-related-pathologies-or-metabolic-diseases
#15
Mercedes Rodriguez-Teja, Claudia Breit, Mitchell Clarke, Kamil Talar, Kai Wang, Mohammad A Mohammad, Sage Pickwell, Guillermina Etchandy, Graeme J Stasiuk, Justin Sturge
Here we describe a protocol that can be used to study the biophysical microenvironment related to increased thickness and stiffness of the basement membrane (BM) during age-related pathologies and metabolic disorders (e.g. cancer, diabetes, microvascular disease, retinopathy, nephropathy and neuropathy). The premise of the model is non-enzymatic crosslinking of reconstituted BM (rBM) matrix by treatment with glycolaldehyde (GLA) to promote advanced glycation endproduct (AGE) generation via the Maillard reaction...
September 20, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27666691/-bone-quality-in-copd
#16
Mitsuru Saito, Keishi Marumo
Chronic obstructive pulmonary disease(COPD)is a chronic inflammatory disease associated with an increase of fracture risk. Bone strength is determined by bone mass and quality.Bone quality is thought to encompass the structural and material properties of bone. Bone collagen crosslinking plays important roles in bone strength. The quantitative and qualitative deterioration of lysyl oxidase control and non enzymatic cross-links(advanced glycation end products, AGEs, pentosidine)of collagen in patients with osteoporotic femoral neck fracture and diabetes, and COPD might be affected by increased oxidative stress and glycation...
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27651252/impact-of-non-enzymatic-glycation-in-neurodegenerative-diseases-role-of-natural-products-in-prevention
#17
Saheem Ahmad, Mohammed Farhan
Non-enzymatic protein glycosylation is the addition of free carbonyls to the free amino groups of proteins, amino acids, lipoproteins and nucleic acids resulting in the formation of early glycation products. The early glycation products are also known as Maillard reaction which undergoes dehydration, cyclization and rearrangement to form advanced glycation end-products (AGEs). By and large the researchers in the past have also established that glycation and the AGEs are responsible for most type of metabolic disorders, including diabetes mellitus, cancer, neurological disorders and aging...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27648753/intra-molecular-lysine-arginine-derived-advanced-glycation-end-product-cross-linking-in-type-i-collagen-a-molecular-dynamics-simulation-study
#18
Thomas A Collier, Anthony Nash, Helen L Birch, Nora H de Leeuw
Covalently cross-linked advanced glycation end products (AGE) are among the major post-translational modifications to proteins as a result of non-enzymatic glycation. The formation of AGEs has been shown to have adverse effects on the properties of the collagenous tissue; they are even linked to a number of age related disorders. Little is known about the sites at which these AGEs form or why certain sites within the collagen are energetically more favourable than others. In this study we have used a proven fully atomistic molecular dynamics approach to identify six sites where the formation of the intra-molecular 3-deoxyglucosone-derived imidazolium cross-link (DOGDIC) is energetically favourable...
November 2016: Biophysical Chemistry
https://www.readbyqxmd.com/read/27643756/effects-of-hyperglycemia-on-bone-metabolism-and-bone-matrix-in-goldfish-scales
#19
Kei-Ichiro Kitamura, Tadashi Andoh, Wakana Okesaku, Yuya Tazaki, Kazuhiro Ogai, Kayo Sugitani, Isao Kobayashi, Nobuo Suzuki, Wenxi Chen, Mika Ikegame, Atsuhiko Hattori
Increased risk of fracture associated with type 2 diabetes has been a topic of recent concern. Fracture risk is related to a decrease in bone strength, which can be affected by bone metabolism and the quality of the bone. To investigate the cause of the increased fracture rate in patients with diabetes through analyses of bone metabolism and bone matrix protein properties, we used goldfish scales as a bone model for hyperglycemia. Using the scales of seven alloxan-treated and seven vehicle-treated control goldfish, we assessed bone metabolism by analyzing the activity of marker enzymes and mRNA expression of marker genes, and we measured the change in molecular weight of scale matrix proteins with SDS-PAGE...
September 16, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27598437/glycation-in-human-fingernail-clippings-using-atr-ftir-spectrometry-a-new-marker-for-the-diagnosis-and-monitoring-of-diabetes-mellitus
#20
Renaat Coopman, Thijs Van de Vyver, Antoine Sadiki Kishabongo, Philippe Katchunga, Elisabeth H Van Aken, Justin Cikomola, Tinne Monteyne, Marijn M Speeckaert, Joris R Delanghe
OBJECTIVES: Although HbA1c is a good diagnostic tool for diabetes, the precarity of the health system and the costs limit the use of this biomarker in developing countries. Fingernail clippings contain ±85% of keratins, which are prone to glycation. Nail keratin glycation may reflect the average glycemia over the last months. We explored if attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) can be used as a non-invasive tool for assessing glycation in diabetes...
September 3, 2016: Clinical Biochemistry
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