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Non Enzymatic Glycation

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https://www.readbyqxmd.com/read/29758984/the-inhibition-of-methylglyoxal-induced-histone-h1-n%C3%AE%C2%B5-carboxymethyllysine-formation-by-catechin
#1
Lijun Yang, Xinping Li, Zhaozhen Wu, Cuixia Feng, Tianyu Zhang, Shaohua Dai, Qiang Dong
Reactive dicarbonyl species (RCS) such as methylglyoxal (MGO) and glyoxal (GO) are common intermediates in protein damage, leading to the formation of advanced glycation end products (AGEs) through nonenzymatic glycation. (+)-Catechin, a natural plant extract from tea, has been evaluated for its ability in trapping GO and MGO. However, (+)-catechin also is reported to have both anti-oxidant ability and pro-oxidant properties. Till now, whether (+)-catechin can inhibit the formation and its mechanism in nucleoprotein nonenzymatic glycation is still unclear...
May 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29756175/zinc-supplementation-ameliorates-diabetic-cataract-through-modulation-of-crystallin-proteins-and-polyol-pathway-in-experimental-rats
#2
Susmita Barman, Krishnapura Srinivasan
Non-enzymatic glycation of lens proteins and elevated polyol pathway in the eye lens have been the characteristic features of a diabetic condition. We have previously reported the benefits of zinc supplementation in reducing hyperglycemia and associated metabolic abnormalities and oxidative stress in diabetic rats. The current study explored whether zinc supplementation protects against cataractogenesis through modulation of glycation of lens proteins, elevated polyol pathway, oxidative stress, and proportion of different heat shock proteins in the eye lens of diabetic rats...
May 13, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29660289/can-glycation-reduce-food-allergenicity
#3
Qinchun Rao, Xingyi Jiang, Yida Li, Mustafa Samiwala, Theodore P Labuza
As a naturally occurring reaction during food processing, glycation, also known as non-enzymatic browning or Maillard reaction, can improve food protein physiochemical properties and functionality. In this perspective, three aspects of glycation (terminology confusion between glycation and glycosylation, its current application, and its impact on immunoreactivity) are elaborated. Overall, the immunoreactivity of glycated proteins may decrease, remain unchanged, or even increase after food glycation. Also, it should be noted that the effect of glycation on the immunoglobulin (Ig)E- or IgG-binding capacity of allergens do not necessarily and correctly predict the allergenicity of the glycated protein in the allergic patient population...
April 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29651042/effects-of-scavenger-receptors-1-class-a-stimulation-on-macrophage-morphology-and-highly-modified-advanced-glycation-end-product-protein-phagocytosis
#4
Shinichi Hamasaki, Takuro Kobori, Yui Yamazaki, Atsuhiro Kitaura, Atsuko Niwa, Takashi Nishinaka, Masahiro Nishibori, Shuji Mori, Shinichi Nakao, Hideo Takahashi
Advanced glycation end-products (AGEs), which comprise non-enzymatically glycosylated proteins, lipids, and nucleic acid amino groups, play an important role in several diseases and aging processes including angiopathy, renal failure, diabetic complications, and neurodegenerative diseases. Among AGE-associated phenotypes, toxic AGEs, glyceraldehyde-derived AGE-2, and glycolaldehyde-derived AGE-3 are involved in the pathogenesis of diabetic complications. In addition, macrophages are reported to remove extracellular AGEs from tissues via scavenger receptors, leading to the progression of atherosclerosis...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29644926/role-of-ligands-of-receptor-for-advanced-glycation-end-products-rage-in-peripheral-artery-disease
#5
Sho-Ichi Yamagishi, Takanori Matsui
Atherosclerotic cardiovascular disease, including peripheral artery disease (PAD) is more common and severe in diabetic patients compared with non-diabetic individuals. Indeed, diabetes is associated with the increased risk of limb amputation and all-cause mortality in patients with symptomatic PAD. Proteins and lipids are non-enzymatically modified by sugars, resulting in the formation and accumulation of advanced glycation end products (AGEs), whose process is accelerated under diabetic conditions, especially patients with a long duration of diabetes...
April 12, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29619544/effect-of-glycation-on-human-serum-albumin-zinc-interaction-a-biophysical-study
#6
Sarah Iqbal, Faizan Abul Qais, Md Maroof Alam, Imrana Naseem
Zinc deficiency is common in diabetes. However, the cause of this phenomenon is largely unknown. 80% of the absorbed zinc is transported through the blood in association with human serum albumin (HSA). Under persistent hyperglycemia, HSA frequently undergoes non-enzymatic glycation which can affect its structure and metal-binding function. Hence, in this study, we have examined the interaction of zinc with native and glycated HSA. The protein samples were incubated either in the presence or in the absence of physiologically elevated glucose concentration for 21 days...
April 4, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29570835/influence-of-diabetes-on-tissue-healing-in-orthopedic-injuries
#7
REVIEW
Artur Stolarczyk, Sylwia Sarzyńska, Agata Gondek, Agnieszka Cudnoch-Jędrzejewska
Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from the defective action or secretion of insulin. Chronic hyperglycemia can lead to the damage, dysfunction and failure of various organs. In the context of complications of healing and orthopedic rehabilitation, vascular (microangiopathy) and nerve (neuropathy) disorders deserve particular attention. About 12% of the patients admitted to orthopedic departments have diabetes. Studies indicate that there is an indisputable link between diabetes and: an increased risk of fractures, the difficult healing of injuries of bones, ligaments and musculotendinous...
March 23, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29480231/alpha-synuclein-glycation-and-the-action-of-anti-diabetic-agents-in-parkinson-s-disease
#8
Annekatrin König, Hugo Vicente Miranda, Tiago Fleming Outeiro
 Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology and variable pathology. While a subset of cases is associated with single-gene mutations, the majority originates from a combination of factors we do not fully understand. Thus, understanding the underlying causes of PD is indispensable for the development of novel therapeutics. Glycation, the non-enzymatic reaction between reactive dicarbonyls and amino groups, gives rise to a variety of different reaction products known as advanced glycation end products (AGEs)...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29431803/cretan-tea-origanum-dictamnus-l-as-a-functional-beverage-an-investigation-on-antiglycative-and-carbonyl-trapping-activities
#9
Mariarosa Maietta, Raffaella Colombo, Federica Corana, Adele Papetti
Accumulation of advanced glycation end products (AGEs) in vivo is associated with many chronic disorders such as diabetes, renal failure, aging, and Alzheimer's disease. The aim of this study was to expand the knowledge about the functional properties of Origanum dictamnus L. beverage (Cretan tea) by an investigation about the inhibitory effects on the formation of AGEs and the capacity to trap dicarbonyl compounds. Dittany infusion was characterized for its polyphenolic composition by RP-HPLC-DAD-ESI/MSn and twenty compounds were detected...
March 1, 2018: Food & Function
https://www.readbyqxmd.com/read/29425747/annona-muricata-linn-leaf-as-a-source-of-antioxidant-compounds-with-in-vitro-antidiabetic-and-inhibitory-potential-against-%C3%AE-amylase-%C3%AE-glucosidase-lipase-non-enzymatic-glycation-and-lipid-peroxidation
#10
Allisson Benatti Justino, Natália Carnevalli Miranda, Rodrigo Rodrigues Franco, Mário Machado Martins, Neide Maria da Silva, Foued Salmen Espindola
Annona muricata leaves are used in traditional medicine to manage diabetes mellitus and its complications. The aim of this study was to evaluate the potential in vitro antidiabetic properties of Annona muricata leaf by identifying its main phytochemical constituents and characterizing the phenolic-enriched fractions for their in vitro antioxidant capacity and inhibitory activities against glycoside and lipid hydrolases, advanced glycation end-product formation and lipid peroxidation. Ethanol extract of A. muricata leaf was subjected to a liquid-liquid partitioning and its fractions were used in enzymatic assays to evaluate their inhibitory potential against α-amylase, α-glucosidase and lipase, as well as their antioxidant (DPPH, ORAC, FRAP and Fe2+ -ascorbate-induced lipid peroxidation assays) and anti-glycation (BSA-fructose, BSA-methylglyoxal and arginine-methylglyoxal models) capacities...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29420566/a-novel-monoclonal-antibody-targeting-carboxymethyllysine-an-advanced-glycation-end-product-in-atherosclerosis-and-pancreatic-cancer
#11
Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, Björn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt
Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function. The resulting modifications induce inflammation by binding to scavenger receptors. An increase in advanced glycation end products is observed in a number of diseases e.g. atherosclerosis and cancer. Since advanced glycation end products also are present in healthy individuals, their detection and quantification are of great importance for usage as potential biomarkers...
2018: PloS One
https://www.readbyqxmd.com/read/29408699/accumulation-of-carboxymethyl-lysine-cml-in-human-cortical-bone
#12
Corinne J Thomas, Timothy P Cleland, Grazyna E Sroga, Deepak Vashishth
Advanced glycation end-products (AGEs) are a category of post translational modification associated with the degradation of the structural properties of multiple different types of tissues. Typically, AGEs are the result of a series of post-translational modification reactions between sugars and proteins through a process known as non-enzymatic glycation (NEG). Increases in the rate of NEG of bone tissue are associated with type 2 diabetes and skeletal fragility. Current methods of assessing NEG and its impact on bone fracture risk involve measurement of pentosidine or total fluorescent AGEs (fAGEs)...
May 2018: Bone
https://www.readbyqxmd.com/read/29365096/immune-neutralization-of-the-receptor-for-advanced-glycation-endproducts-reduce-liver-oxidative-damage-induced-by-an-acute-systemic-injection-of-lipopolysaccharide
#13
Camila Tiefensee Ribeiro, Juciano Gasparotto, Alexsander Alves Teixeira, Luis Valmor Cruz Portela, Viviane Noll Louzada Flores, José Claudio Fonseca Moreira, Daniel Pens Gelain
The receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor, which activation amplifies and perpetuates inflammatory reactions. RAGE activation also strongly stimulates the production of reactive oxygen species, leading an imbalance of redox cellular state. The extent of liver damage caused by inflammation is crucial to the systemic response during proinflammatory episodes. To investigate the role of RAGE in liver damage caused by systemic inflammation, we evaluated the effect of RAGE blocking in oxidative stress parameters induced by systemic LPS injection...
January 22, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29359356/the-value-of-glycated-albumin-for-the-prediction-of-graft-outcome-in-the-non-human-primate-porcine-islet-transplantation-model
#14
Hee Jung Kang, Haneulnari Lee, Eun Mi Park, Jong-Min Kim, Jun-Seop Shin, Chung-Gyu Park
BACKGROUND: The development of a precise and easy-to-use tool for monitoring islet graft function is important in clarifying the causes of graft loss, identifying appropriate therapy, and ensuring graft survival in the nonhuman primate (NHP) model of porcine islet transplantation (PITx). Glycated albumin (GA) is an indicator of intermediate-term changes in blood glucose control and is useful in clinical diabetes management. The validity of GA for monitoring graft function in NHP recipients of PITx was evaluated using a retrospective analysis of cohort samples...
March 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29355739/nicotine-induces-apoptosis-in-human-osteoblasts-via-a-novel-mechanism-driven-by-h-2-o-2-and-entailing-glyoxalase-1-dependent-mg-h1-accumulation-leading-to-tg2-mediated-nf-kb-desensitization-implication-for-smokers-related-osteoporosis
#15
Lorella Marinucci, Stefania Balloni, Katia Fettucciari, Maria Bodo, Vincenzo N Talesa, Cinzia Antognelli
Nicotine contained in cigarette smoke contributes to the onset of several diseases, including osteoporosis, whose emerging pathogenic mechanism is associated with osteoblasts apoptosis. Scanty information is available on the molecular mechanisms of nicotine on osteoblasts apoptosis and, consequently, on an important aspect of the pathogenesis of smokers-related osteoporosis. Glyoxalase 1 (Glo1) is the detoxification enzyme of methylglyoxal (MG), a major precursor of advanced glycation end products (AGEs), potent pro-apoptotic agents...
March 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29351321/methylglyoxal-produces-more-changes-in-biochemical-and-biophysical-properties-of-human-igg-under-high-glucose-compared-to-normal-glucose-level
#16
COMPARATIVE STUDY
Mohd Adnan Khan, Zarina Arif, Mohd Asad Khan, Moinuddin, Khursheed Alam
Hyperglycaemia triggers increased production of methylglyoxal which can cause gross modification in proteins' structure vis-a-vis function though advanced glycation end products (AGEs). The AGEs may initiate vascular and nonvascular pathologies. In this study, we have examined the biochemical and biophysical changes in human IgG under normal and high glucose after introducing methylglyoxal into the assay mixture. This non-enzymatic reaction mainly engaged lysine residues as indicated by TNBS results. The UV results showed hyperchromicity in modified-IgG samples while fluorescence data supported AGEs formation during the course of reaction...
2018: PloS One
https://www.readbyqxmd.com/read/29334127/non-enzymatic-cross-linking-of-collagen-type-ii-fibrils-is-tuned-via-osmolality-switch
#17
Behdad Pouran, Parisa R Moshtagh, Vahid Arbabi, Jessica Snabel, Reinout Stoop, Jeffrey Ruberti, Jos Malda, Amir A Zadpoor, Harrie Weinans
An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in cross-links formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the current study, we investigate whether collagen cross-linking after exposure to sugars depends on the stretching condition of the collagen fibrils. Healthy equine cartilage specimens were exposed to l-threose sugar and placed in hypo-, iso-, or hyper-osmolal conditions that expanded or shrank the tissue and changed the 3D conformation of collagen fibrils...
January 15, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29331666/age-related-oxidative-changes-in-pancreatic-islets-are-predominantly-located-in-the-vascular-system
#18
Richard Kehm, Jeannette König, Kerstin Nowotny, Tobias Jung, Stephanie Deubel, Sabrina Gohlke, Tim Julius Schulz, Annika Höhn
Aged tissues usually show a decreased regenerative capacity accompanied by a decline in functionality. During aging pancreatic islets also undergo several morphological and metabolic changes. Besides proliferative and regenerative limitations, endocrine cells lose their secretory capacity, contributing to a decline in functional islet mass and a deregulated glucose homeostasis. This is linked to several features of aging, such as induction of cellular senescence or the formation of modified proteins, such as advanced glycation end products (AGEs) - the latter mainly examined in relation to hyperglycemia and in disease models...
May 2018: Redox Biology
https://www.readbyqxmd.com/read/29300762/drug-repurposing-in-vitro-anti-glycation-properties-of-18-common-drugs
#19
Saima Rasheed, Sara S Sánchez, Sammer Yousuf, Stella M Honoré, M Iqbal Choudhary
Drug repositioning or repurposing, i.e. identifying new indications for existing drugs, has gained increasing attention in the recent years. This approach enables the scientists to discover "new targets" for known drugs in a cost and time efficient manner. Glycation, the non-enzymatic reaction of sugars with proteins or nucleic acids to form early glycation (Amadori or fructosamine) products, is a key molecular basis of diabetic complications. Inhibiting the process of non-enzymatic protein glycation is one of the key strategies to prevent glycation-mediated diabetic complications...
2018: PloS One
https://www.readbyqxmd.com/read/29291594/a-non-enzymatic-two-step-catalytic-reduction-of-methylglyoxal-by-nanostructured-v-2-o-5-modified-electrode
#20
Lakshmishri Ramachandra Bhat, Srinivasan Vedantham, Uma Maheswari Krishnan, John Bosco Balaguru Rayappan
Methylglyoxal (MG) is a predominant precursor for advanced glycation end products (AGEs) due to its protein glycation reactions, which are the major causes of diabetic complications. MG is explored as a significant biomarker towards the prediction of diabetic complications. With this background, a non-enzymatic electrochemical biosensor has been developed to detect MG in human blood plasma samples. Microwave synthesized V2 O5 nanoplates were used as interface material in the fabrication of modified gold (Au) working electrode for electrochemical MG biosensor...
April 30, 2018: Biosensors & Bioelectronics
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