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Non Enzymatic Glycation

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https://www.readbyqxmd.com/read/29334127/non-enzymatic-cross-linking-of-collagen-type-ii-fibrils-is-tuned-via-osmolality-switch
#1
Behdad Pouran, Parisa R Moshtagh, Vahid Arbabi, Jessica Snabel, Reinout Stoop, Jeffrey Ruberti, Jos Malda, Amir A Zadpoor, Harrie Weinans
An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in crosslinks formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the current study, we investigate whether collagen crosslinking after exposure to sugars depends on the stretching condition of the collagen fibrils. Healthy equine cartilage specimens were exposed to L-threose sugar and placed in hypo-, iso- or hyper-osmolal conditions that expanded or shrank the tissue and changed the 3D conformation of collagen fibrils...
January 15, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29331666/age-related-oxidative-changes-in-pancreatic-islets-are-predominantly-located-in-the-vascular-system
#2
Richard Kehm, Jeannette König, Kerstin Nowotny, Tobias Jung, Stephanie Deubel, Sabrina Gohlke, Tim Julius Schulz, Annika Höhn
Aged tissues usually show a decreased regenerative capacity accompanied by a decline in functionality. During aging pancreatic islets also undergo several morphological and metabolic changes. Besides proliferative and regenerative limitations, endocrine cells lose their secretory capacity, contributing to a decline in functional islet mass and a deregulated glucose homeostasis. This is linked to several features of aging, such as induction of cellular senescence or the formation of modified proteins, such as advanced glycation end products (AGEs) - the latter mainly examined in relation to hyperglycemia and in disease models...
December 29, 2017: Redox Biology
https://www.readbyqxmd.com/read/29300762/drug-repurposing-in-vitro-anti-glycation-properties-of-18-common-drugs
#3
Saima Rasheed, Sara S Sánchez, Sammer Yousuf, Stella M Honoré, M Iqbal Choudhary
Drug repositioning or repurposing, i.e. identifying new indications for existing drugs, has gained increasing attention in the recent years. This approach enables the scientists to discover "new targets" for known drugs in a cost and time efficient manner. Glycation, the non-enzymatic reaction of sugars with proteins or nucleic acids to form early glycation (Amadori or fructosamine) products, is a key molecular basis of diabetic complications. Inhibiting the process of non-enzymatic protein glycation is one of the key strategies to prevent glycation-mediated diabetic complications...
2018: PloS One
https://www.readbyqxmd.com/read/29291594/a-non-enzymatic-two-step-catalytic-reduction-of-methylglyoxal-by-nanostructured-v2o5-modified-electrode
#4
Lakshmishri Ramachandra Bhat, Srinivasan Vedantham, Uma Maheswari Krishnan, John Bosco Balaguru Rayappan
Methylglyoxal (MG) is a predominant precursor for advanced glycation end products (AGEs) due to its protein glycation reactions, which are the major causes of diabetic complications. MG is explored as a significant biomarker towards the prediction of diabetic complications. With this background, a non-enzymatic electrochemical biosensor has been developed to detect MG in human blood plasma samples. Microwave synthesized V2O5 nanoplates were used as interface material in the fabrication of modified gold (Au) working electrode for electrochemical MG biosensor...
December 23, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29281127/bone-tissue-collagen-maturity-and-mineral-content-increase-with-sustained-hyperglycemia-in-the-kk-ay-murine-model-of-type-2-diabetes
#5
Heather B Hunt, Jared C Pearl, David R Diaz, Karen B King, Eve Donnelly
Type 2 diabetes mellitus (T2DM) increases fracture risk for a given bone mineral density, which suggests that T2DM changes bone tissue properties independently of bone mass. In this study, we assessed the effects of hyperglycemia on bone tissue compositional properties, enzymatic collagen crosslinks, and advanced glycation endproducts (AGEs) in the KK-Ay murine model of T2DM using Fourier transform infrared imaging and high-performance liquid chromatography. Compared to KK-aa littermate controls (n = 8), proximal femoral bone tissue of KK-Ay mice (n = 14) exhibited increased collagen maturity, increased mineral content, and less heterogeneous mineral properties...
December 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29250665/the-correlation-between-insulin-like-growth-factor-with-glycemic-control-glomerular-filtration-rate-blood-pressure-hematological-changes-or-body-mass-index-in-patients-with-type-2-diabetes-mellitus
#6
Marius Cristian NeamŢu, Elena Taina Avramescu, Iulia Rahela Marcu, Adina Turcu-Ştiolică, Mihail Virgil Boldeanu, Oana Maria NeamŢu, Ştefania Tudorache, Rucsandra Elena Dănciulescu Miulescu
Insulin-like growth factor (IGF) family is made up of two polypeptides, IGF-I and IGF-II, six specific binding proteins (IGFBPs 1-6) and specific receptors. IGF-I is involved in the regulation of growth and cellular proliferation and has a similar structure to insulin. The major IGF transport function is attributed to IGFBP-3. Some studies have highlighted the association between IGF and diabetes. The aims of this study were to analyze the correlation between IGF with glycemic control, glomerular filtration rate (GFR), blood pressure, hematological changes or body mass index (BMI) in patients with type 2 diabetes mellitus (T2DM)...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29231845/maillard-proteomics-opening-new-pages
#7
REVIEW
Alena Soboleva, Rico Schmidt, Maria Vikhnina, Tatiana Grishina, Andrej Frolov
Protein glycation is a ubiquitous non-enzymatic post-translational modification, formed by reaction of protein amino and guanidino groups with carbonyl compounds, presumably reducing sugars and α-dicarbonyls. Resulting advanced glycation end products (AGEs) represent a highly heterogeneous group of compounds, deleterious in mammals due to their pro-inflammatory effect, and impact in pathogenesis of diabetes mellitus, Alzheimer's disease and ageing. The body of information on the mechanisms and pathways of AGE formation, acquired during the last decades, clearly indicates a certain site-specificity of glycation...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29207492/rapid-non-enzymatic-glycation-of-the-insulin-receptor-under-hyperglycemic-conditions-inhibits-insulin-binding-in-vitro-implications-for-insulin-resistance
#8
Tyler Rhinesmith, Thomas Turkette, Robert Root-Bernstein
The causes of insulin resistance are not well-understood in either type 1 or type 2 diabetes. Insulin (INS) is known to undergo rapid non-enzymatic covalent conjugation to glucose or other sugars (glycation). Because the insulin receptor (IR) has INS-like regions associated with both glucose and INS binding, we hypothesize that hyperglycemic conditions may rapidly glycate the IR, chronically interfering with INS binding. IR peptides were synthesized spanning IR- associated INS-binding regions. Glycation rates of peptides under hyperglycemic conditions were followed over six days using matrix assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry...
December 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29195953/effect-of-glycation-derived-from-%C3%AE-dicarbonyl-compounds-on-the-in-vitro-digestibility-of-%C3%AE-casein-and-%C3%AE-lactoglobulin-a-model-study-with-glyoxal-methylglyoxal-and-butanedione
#9
Di Zhao, Thao T Le, Lotte Bach Larsen, Lin Li, Dan Qin, Guoying Su, Bing Li
α-Dicarbonyl compounds, which are widely found in common consumed food, are one of the precursors of advanced glycation end products (AGEs). In this study, the effect of glycation derived from glyoxal (GO), methylglyoxal (MGO) or butanedione (BU) on the in vitro digestibility of β-casein (β-CN) and β-lactoglobulin (β-Lg) was investigated. Glycation from α-dicarbonyl compounds reduced the in vitro digestibility of studied proteins in both gastric and intestinal stage. In addition, glycation substantially altered the peptides released through gastric and gastrointestinal digestion, as detected by liquid chromatography electrospray-ionization tandem mass spectrometry (LC-ESI-MS/MS)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29192920/in-situ-characterization-of-advanced-glycation-end-products-ages-in-collagen-and-model-extracellular-matrix-by-solid-state-nmr
#10
R Li, R Rajan, W C V Wong, D G Reid, M J Duer, V J Somovilla, N Martinez-Saez, G J L Bernardes, R Hayward, C M Shanahan
Non-enzymatic glycation of extracellular matrix with (U-13C5)-d-ribose-5-phosphate (R5P), enables in situ 2D ssNMR identification of many deleterious protein modifications and crosslinks, including previously unreported oxalamido and hemiaminal (CH3-CH(OH)NHR) substructures. Changes in charged residue proportions and distribution may be as important as crosslinking in provoking and understanding harmful tissue changes.
December 1, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29182540/probing-protein-glycation-by-chromatography-and-mass-spectrometry-analysis-of-glycation-adducts
#11
REVIEW
Alena Soboleva, Maria Vikhnina, Tatiana Grishina, Andrej Frolov
Glycation is a non-enzymatic post-translational modification of proteins, formed by the reaction of reducing sugars and α-dicarbonyl products of their degradation with amino and guanidino groups of proteins. Resulted early glycation products are readily involved in further transformation, yielding a heterogeneous group of advanced glycation end products (AGEs). Their formation is associated with ageing, metabolic diseases, and thermal processing of foods. Therefore, individual glycation adducts are often considered as the markers of related pathologies and food quality...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29175521/structural-analysis-of-the-interaction-between-free-glycated-and-fructated-hemoglobin-with-propolis-nanoparticles-a-spectroscopic-study
#12
Fatemeh Kazemi, Adeleh Divsalar, Ali Akbar Saboury
Non enzymatic Glycation is the main causes of diabetic complications. Propolis is a natural product of different plant exudates and buds which has different biological properties such as anti-hyperglycemia. In attention to better performance of nanoparticles in treatment, we synthesized propolis nanoparticles (PNP) and analyzed their physicochemical properties by dynamic light scattering (DLS), scanning electron microscopy (SEM), Zeta potential and FTIR analyses. Then, the structural changes of human hemoglobin (Hb), in three different forms of free, glycated and fructated Hb upon interaction with PNP at two temperatures of 25 and 37°C were investigated using fluorescence and far-UV circular dichoroism (CD) spectroscopic techniques...
November 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29168862/inhibition-of-advanced-glycation-endproducts-during-fish-sausage-preparation-by-transglutaminase-and-chitosan-oligosaccharides-induced-enzymatic-glycosylation
#13
Jing Wang, Long Zou, Fangzhou Yuan, Liangtao Lv, Shenglan Tian, Zhenxing Li, Hong Lin
Advanced glycation endproducts (AGEs) are the harmful products of non-enzymatic reactions in foods formed during the heating process. In order to reduce the content of AGEs in foods, the inhibitory effect of different proportions of transglutaminase (TGase) and chitosan oligosaccharides (COS) on the AGEs of seabream fish meat sausage was studied. The results indicated that the TGase/COS ratio of 1 : 1 could inhibit the formation of AGEs, showing especially a decreased N(ε)-carboxymethyl-lysine (CML) content and a twice higher inhibition rate (36...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29163175/evaluation-of-the-antioxidant-and-antiglycation-effects-of-lactarius-deterrimus-and-castanea-sativa-extracts-on-hepatorenal-injury-in-streptozotocin-induced-diabetic-rats
#14
Jelena Arambašić Jovanović, Mirjana Mihailović, Aleksandra S Uskoković, Nevena Grdović, Svetlana Dinić, Goran Poznanović, Ibrahim Mujić, Melita Vidaković
The present study aimed to investigate the beneficial effects of the treatment with extracts from the edible mushroom Lactarius deterrimus (Ld) and the chestnut Castanea sativa (Cs), separately and in combination (MIX Ld/Cs), on oxidative stress and advanced glycation end-product (AGE)-mediated hepatorenal injury in a rat model of streptozotocin (STZ)-induced diabetes by examining pathways responsible for maintenance of redox homeostasis. An experimental model of diabetes was induced in rats by the administration of 40 mg/kg STZ intraperitoneally (i...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29156655/the-role-of-glyoxalase-i-glo-i-advanced-glycation-endproducts-ages-and-their-receptor-rage-in-chronic-liver-disease-and-hepatocellular-carcinoma-hcc
#15
REVIEW
Marcus Hollenbach
Glyoxalase-I (Glo-I) and glyoxalase-II (Glo-II) comprise the glyoxalase system and are responsible for the detoxification of methylglyoxal (MGO). MGO is formed non-enzymatically as a by-product, mainly in glycolysis, and leads to the formation of advanced glycation endproducts (AGEs). AGEs bind to their receptor, RAGE, and activate intracellular transcription factors, resulting in the production of pro-inflammatory cytokines, oxidative stress, and inflammation. This review will focus on the implication of the Glo-I/AGE/RAGE system in liver injury and hepatocellular carcinoma (HCC)...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29147907/protein-repair-from-glycation-by-glyoxals-by-the-dj-1-family-maillard-deglycases
#16
Mouadh Mihoub, Jad Abdallah, Gilbert Richarme
DJ-1 and its prokaryotic homologs, Hsp31, YhbO and YajL from Escherichia coli and PfpI from Pyrococcus furiosus, repair proteins from glycation by glyoxals (R-CO-CHO), which constitute their major glycating agents. Glycation is a non-enzymatic covalent reaction discovered by Louis Camille Maillard in 1912, between reactive carbonyls (reducing sugars and glyoxals) and amino acids (cysteine, arginine and lysine), which inactivates proteins. By degrading Maillard adducts formed between carbonyls and thiols or amino groups, the DJ-1 family Maillard deglycases prevent the formation of the so-called advanced glycation end products (AGEs) that arise from Maillard adducts after dehydrations, oxidations and rearrangements...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29133088/fructose-human-serum-albumin-interaction-undergoes-numerous-biophysical-and-biochemical-changes-before-forming-ages-and-aggregates
#17
Asif Zaman, Zarina Arif, Moinuddin, Khursheed Alam
Fructose is a reducing and highly lipogenic sugar that has unique metabolic effects in the liver. Non-enzymatic fructosylation of proteins generates advanced glycation end products (AGEs). Human serum albumin (HSA) may undergo fructosylation vis-à-vis AGEs formation. High fructose consumption may lead to structurally altered and functionally compromised fructosylated-HSA-AGEs, which can cause damage to hepatocytes resulting in hepatic macro- and microvesicular steatosis. In this study, HSA was incubated with varying concentrations of fructose for 10days and the induced changes were studied...
November 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29118444/vanillin-affects-amyloid-aggregation-and-non-enzymatic-glycation-in-human-insulin
#18
Clara Iannuzzi, Margherita Borriello, Gaetano Irace, Marcella Cammarota, Antimo Di Maro, Ivana Sirangelo
Curcumin is known for its anti-inflammatory, antioxidant and anticancer activity, as well as for its ability to interfere with amyloid aggregation and non-enzymatic glycation reaction, that makes it an attractive potential drug. However, curcumin therapeutic use is limited because of its low systemic bioavailability and chemical stability as it undergoes rapid hydrolysis in physiological conditions. Recently, much attention has been paid to the biological properties of curcumin degradation products as potential bioactive molecules...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108337/elevated-hemoglobin-glycation-index-identify-non-diabetic-individuals-at-increased-risk-of-kidney-dysfunction
#19
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Angela Sciacqua, Francesco Andreozzi, Francesco Perticone, Giorgio Sesti
Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has been found to be positively associated with nephropathy in subjects with diabetes. In this cross-sectional study we aimed to evaluate whether higher HGI levels are associated with impaired kidney function also among nondiabetic individuals. The study group comprised 1505 White nondiabetic individuals stratified in quartiles according to HGI levels...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29101895/understanding-the-viscoelastic-behavior-of-arterial-elastin-in-glucose-via-relaxation-time-distribution-spectrum
#20
Yunjie Wang, Haiyue Li, Yanhang Zhang
Elastin is a critical extracellular matrix protein that provides many biological tissues with resilience. In elastic arteries such as aorta, elasticity is crucial for energy storage and transmission of the pulsatile blood flow. As one of the main mechanisms of aging, non-enzymatic glycation can greatly compromise the mechanical properties of the long-lived elastin. In this study, effect of glucose on the viscoelastic behavior of purified porcine aortic elastin was investigated through stress relaxation tests and the corresponding relaxation time distribution spectra...
October 20, 2017: Journal of the Mechanical Behavior of Biomedical Materials
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