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Radiation boost tumour bed breast

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https://www.readbyqxmd.com/read/27689969/an-international-randomised-controlled-trial-to-compare-targeted-intraoperative-radiotherapy-targit-with-conventional-postoperative-radiotherapy-after-breast-conserving-surgery-for-women-with-early-stage-breast-cancer-the-targit-a-trial
#1
Jayant S Vaidya, Frederik Wenz, Max Bulsara, Jeffrey S Tobias, David J Joseph, Christobel Saunders, Chris Brew-Graves, Ingrid Potyka, Stephen Morris, Hrisheekesh J Vaidya, Norman R Williams, Michael Baum
BACKGROUND: Based on our laboratory work and clinical trials we hypothesised that radiotherapy after lumpectomy for breast cancer could be restricted to the tumour bed. In collaboration with the industry we developed a new radiotherapy device and a new surgical operation for delivering single-dose radiation to the tumour bed - the tissues at highest risk of local recurrence. We named it TARGeted Intraoperative radioTherapy (TARGIT). From 1998 we confirmed its feasibility and safety in pilot studies...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27579310/comprehensive-evaluation-of-personal-clinical-and-radiation-dosimetric-parameters-for-acute-skin-reaction-during-whole-breast-radiotherapy
#2
Dae Sik Yang, Jung Ae Lee, Won Sup Yoon, Nam Kwon Lee, Young Je Park, Suk Lee, Chul Yong Kim, Gil Soo Son
Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving surgery and adjuvant whole breast irradiation were retrospectively reviewed. All patients had both whole breast irradiation and boost to the tumour bed. Skin reaction was measured on the first day of boost therapy based on photography of the radiation field and medical records...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27452265/comparison-of-two-radiation-techniques-for-the-breast-boost-in-patients-undergoing-neoadjuvant-treatment-for-breast-cancer
#3
Maria C De Santis, Luigia Nardone, Barbara Diletto, Roberta Canna, Michela Dispinzieri, Lorenza Marino, Laura Lozza, Vincenzo Valentini
OBJECTIVE: After breast conservative surgery (BCS) and whole-breast radiotherapy (WBRT), the use of boost irradiation is recommended especially in patients at high risk. However, the standard technique and the definition of the boost volume have not been well defined. METHODS: We retrospectively compared an anticipated pre-operative photon boost on the tumour, administered with low-dose fractionated radiotherapy, and neoadjuvant chemotherapy with two different sequential boost techniques, administered after BCS and standard adjuvant WBRT: (1) a standard photon beam (2) and an electron beam technique on the tumour bed of the same patients...
October 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/26206732/intensity-modulated-radiation-therapy-with-simultaneous-integrated-boost-in-early-breast-cancer-irradiation-report-of-feasibility-and-preliminary-toxicity
#4
A Fiorentino, R Mazzola, F Ricchetti, N Giaj Levra, S Fersino, S Naccarato, G Sicignano, R Ruggieri, G Di Paola, A Massocco, S Gori, F Alongi
PURPOSE: To investigate the feasibility and tolerance in the use of adjuvant intensity modulated radiation therapy (IMRT) and simultaneous integrated boost in patients with a diagnosis of breast cancer after breast-conserving surgery. PATIENTS AND METHODS: Between September 2011 to February 2013, 112 women with a diagnosis of early breast cancer (T1-2, N0-1, M0) were treated with IMRT and simultaneous integrated boost after breast-conserving surgery in our institution...
August 2015: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/26006764/-radiosensitivity-settings-in-breast-cancer
#5
O Lauche, D Azria, O Riou, M Charissoux, C Lemanski, C Bourgier
Breast cancers are highly radiosensitive since the risk of recurrences and of mortality after adjuvant radiotherapy following breast-conserving surgery is decreased by 15.7% and 3.8%, respectively at 10 years. The total dose if irradiation also significantly increases local control: a boost of 16 Gy to the tumour bed after breast-conserving surgery reduces the absolute risk of recurrence by 4% at 10 years. Breast cancers are sensitive to the dose per fraction, as shown by the results from four randomized trials which compared standard irradiation (50 Gy/25 fractions) with a hypofractionated scheme: no statistical difference was observed in locoregional recurrence and overall survival at 10 years...
June 2015: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/25752562/radiation-therapy-in-the-locoregional-treatment-of-triple-negative-breast-cancer
#6
REVIEW
Meena S Moran
This Review assesses the relevant data and controversies regarding the use of radiotherapy for, and locoregional management of, women with triple-negative breast cancer (TNBC). In view of the strong association between BRCA1 and TNBC, knowledge of baseline mutation status can be useful to guide locoregional treatment decisions. TNBC is not a contraindication for breast conservation therapy because data suggest increased locoregional recurrence risks (relative to luminal subtypes) with breast conservation therapy or mastectomy...
March 2015: Lancet Oncology
https://www.readbyqxmd.com/read/25174061/analysis-of-radiation-induced-angiosarcoma-of-the-breast
#7
M Zemanova, K Rauova, E Boljesikova, K Machalekova, I Krajcovicova, V Lehotska, M Mikulova, J Svec
Breast angiosarcoma may occur de novo, or as a complication of radiation therapy, or chronic lymphedema secondary to axillary lymph node dissection for mammary carcinoma. Both primary and secondary angiosarcomas may present with bruise like skin discoloration, which may delay the diagnosis. Imaging findings are nonspecific. In case of high-grade tumours, MRI may be used effectively to determine lesion extent by showing rapid enhancement, nevertheless earliest possible diagnostics is crucial therefore any symptoms of angiosarcoma have to be carefully analysed...
2014: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/24929648/the-effect-of-image-guidance-on-dose-distributions-in-breast-boost-radiotherapy
#8
E M Donovan, C Brooks, R A Mitchell, M Mukesh, C E Coles, P M Evans, E J Harris
AIMS: To determine the effect of image-guided radiotherapy on the dose distributions in breast boost treatments. MATERIALS AND METHODS: Computed tomography images from a cohort of 60 patients treated within the IMPORT HIGH trial (CRUK/06/003) were used to create sequential and concomitant boost treatment plans (30 cases each). Two treatment plans were created for each case using tumour bed planning target volume (PTV) margins of 5 mm (achieved with image-guided radiotherapy) and 8 mm (required for bony anatomy verification)...
November 2014: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/24761855/hypofractionated-radiotherapy-for-breast-cancers-preliminary-results-from-a-tertiary-care-center-in-eastern-india
#9
Moujhuri Nandi, Anurupa Mahata, Indranil Mallick, Rimpa Achari, Sanjoy Chatterjee
BACKGROUND: The standard radiotherapy (RT) fractionation practiced in India and worldwide is 50 Gy in 25 fractions over 5 weeks to the chest wall or whole breast followed by tumour bed boost in case of breast conservation (BCS). A body of validated data exists regarding hypofractionation in breast cancer. We here report initial results for 135 patients treated at our center with the START-B type of fractionation. MATERIALS AND METHODS: From May 2011 till July 2012, women with all stages of breast cancer (excluding metastatic), who had undergone BCS or mastectomy were planned for 40 Gy in 15 fractions over 3 weeks to chest wall/whole breast and supraclavicular fossa (where indicated) followed by tumour bed boost in BCS patients...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/24679650/-safety-and-efficacy-of-whole-breast-irradiation-with-a-concomitant-boost-analysis-of-121-cases-treated-at-the-institute-of-cancerology-of-lorraine
#10
F Renoult, C Marchal, C Brunaud, V Harter, D Peiffert
PURPOSE: To evaluate the safety and efficacy of whole breast irradiation with a concomitant boost. PATIENTS AND MATERIALS: This is a retrospective study of 121 patients with node negative T1-T2 breast tumors inferior to 3 cm in diameter, previously treated by conservative surgery without chemotherapy. A dose of 50 Gy was delivered to the whole breast in 2 Gy daily fractions with 5 weekly treatments. A concomitant boost to the lumpectomy site delivered a total of 10 Gy in 1 Gy fractions twice a week...
June 2014: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/24470733/radiation-induced-pneumonitis-following-whole-breast-radiotherapy-treatment-in-early-breast-cancer-patients-treated-with-breast-conserving-surgery-a-single-institution-study
#11
I Fragkandrea, V Kouloulias, P Mavridis, A Zettos, S Betsou, P Georgolopoulou, A Sotiropoulou, A Gouliamos, I Kouvaris
BACKGROUND: Hypofractionated Radiotherapy (RT) regimens for breast cancer, although reduce cost and time for patients and health care systems, could have a negative impact on normal underlying lung tissue. We studied and compared lung function and the post-RT radiological changes using High-Resolution Computed Tomography (HRCT) in early breast cancer patients, treated with 3-Dimentional conformal whole breast radiotherapy (WBRT) using either conventional or hypofractionated regime. PATIENTS AND METHODS: Between 2008 and 2009, 61 early breast cancer patients (T1-2N0M0) were randomised into two groups ...
July 2013: Hippokratia
https://www.readbyqxmd.com/read/24416541/intraoperative-radiation-therapy-as-part-of-breast-conserving-therapy-of-early-breast-cancer-results-of-one-year-follow-up
#12
Zaneta Wareńczak-Florczak, Andrzej Roszak, Krystyna Bratos, Piotr Milecki, Aldona Karczewska-Dzionk, Hanna Włodarczyk
AIM: The aim of this study was to assess the therapeutic effect of intraoperative radiotherapy, describe the method, and examine the occurrence of side effects and quality of life. BACKGROUND: Breast conserving therapy has recently become a standard treatment modality in patients with early invasive cancer. Radiotherapy, along with surgery, is an integral part of such treatment. The important thing of radiotherapy is to deliver a high dose to the tumour bed. One of the methods is the intraoperative radiotherapy...
2013: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/24316350/-preliminary-results-of-whole-breast-helical-tomotherapy-with-simultaneous-integrated-boost-in-the-adjuvant-treatment-of-breast-cancer
#13
X Liem, C Chira, A Fourquet, F Campana, D Peurien, N Fournier-Bidoz, Y M Kirova
PURPOSE: To evaluate the dosimetry and acute toxicity of helical tomotherapy for locoregional irradiation of patients after breast-conserving surgery. PATIENTS AND METHODS: Twenty breast cancer patients with breast-conserving surgery treated by helical tomotherapy have been studied. The median age was 49 (min: 25, max: 69). The whole breast, tumour bed and lymph nodes were prescribed 52.2 Gy, 63.8 Gy and 50.4 Gy, all in 29 fractions. The dose per fraction was 2...
January 2014: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/23651532/standard-or-hypofractionated-radiotherapy-in-the-postoperative-treatment-of-breast-cancer-a-retrospective-analysis-of-acute-skin-toxicity-and-dose-inhomogeneities
#14
Grazia Tortorelli, Luana Di Murro, Rosaria Barbarino, Sara Cicchetti, Daniela di Cristino, Maria Daniela Falco, Dahlia Fedele, Gianluca Ingrosso, Dania Janniello, Pasquale Morelli, Alessandra Murgia, Elisabetta Ponti, Sara Terenzi, Barbara Tolu, Riccardo Santoni
BACKGROUND: To identify predictive factors of radiation-induced skin toxicity in breast cancer patients by the analysis of dosimetric and clinical factors. METHODS: 339 patients treated between January 2007 and December 2010 are included in the present analysis. Whole breast irradiation was delivered with Conventional Fractionation (CF) (50 Gy, 2.0/day, 25 fractions) and moderate Hypofractionated Schedule (HS) (44 Gy, 2.75 Gy/day, 16 fractions) followed by tumour bed boost...
2013: BMC Cancer
https://www.readbyqxmd.com/read/23453755/-brachytherapy-of-breast-cancer
#15
REVIEW
M-È Chand, S Rivera, C Hennequin, J-M Hannoun-Lévi, L Quero
For breast cancer, interstitial brachytherapy remains an accurate irradiation technique for delivering a high dose (increasing the local control) in a small volume (decreasing the toxicity). In this article, we present the technical data related to the breast brachytherapy proceeding, from the implantation of the vectors to the treatment itself, including the planning. The different indications of breast brachytherapy include all the breast irradiations focusing on the initial tumour bed (partial irradiation of the breast), such as boost, accelerated and partial breast irradiation (APBI) and second conservative radiosurgical treatment in case of ipsilateral in-breast recurrence...
April 2013: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/23098066/conservative-treatment-of-breast-ductal-carcinoma-in-situ-results-of-an-italian-multi-institutional-retrospective-study
#16
MULTICENTER STUDY
Cristiana Vidali, Orazio Caffo, Cynthia Aristei, Filippo Bertoni, Alberto Bonetta, Marina Guenzi, Cinzia Iotti, Maria Cristina Leonardi, Salvatore Mussari, Stefano Neri, Nicoletta Pietta
BACKGROUND: The incidence of ductal carcinoma in situ (DCIS) has increased markedly in recent decades. In the past, mastectomy was the primary treatment for patients with DCIS, but as with invasive cancer, breast-conserving surgery followed by radiation therapy (RT) has become the standard approach. We present the final results of a multi-institutional retrospective study of an Italian Radiation Oncology Group for the study of conservative treatment of DCIS, characterized by a very long period of accrual, from February 1985 to March 2000, and a median follow-up longer than 11 years...
2012: Radiation Oncology
https://www.readbyqxmd.com/read/22929062/phase-i-ii-study-of-hypofractionated-simultaneous-integrated-boost-using-volumetric-modulated-arc-therapy-for-adjuvant-radiation-therapy-in-breast-cancer-patients-a-report-of-feasibility-and-early-toxicity-results-in-the-first-50-treatments
#17
Marta Scorsetti, Filippo Alongi, Antonella Fogliata, Sara Pentimalli, Pierina Navarria, Francesca Lobefalo, Carlos Garcia-Etienne, Alessandro Clivio, Luca Cozzi, Pietro Mancosu, Giorgia Nicolini, Eugenio Vanetti, Marco Eboli, Carlo Rossetti, Arianna Rubino, Andrea Sagona, Stefano Arcangeli, Wolfgang Gatzemeier, Giovanna Masci, Rosalba Torrisi, Alberto Testori, Marco Alloisio, Armando Santoro, Corrado Tinterri
BACKGROUND: To report results in terms of feasibility and early toxicity of hypofractionated simultaneous integrated boost (SIB) approach with Volumetric Modulated Arc Therapy (VMAT) as adjuvant treatment after breast-conserving surgery. METHODS: Between September 2010 and May 2011, 50 consecutive patients presenting early-stage breast cancer were submitted to adjuvant radiotherapy with SIB-VMAT approach using RapidArc in our Institution (Istituto Clinico Humanitas ICH)...
2012: Radiation Oncology
https://www.readbyqxmd.com/read/22925491/-late-sequelae-and-cosmetic-outcome-after-radiotherapy-in-breast-conserving-therapy
#18
M Doré, C Hennequin
Radiotherapy after breast-conserving therapy for early breast cancer is reported to adversely affect the cosmetic outcome. The incidence of radiation-induced fibroatrophy is around 10% at 5 years. A better knowledge of its pathophysiology has revealed the essential role of activated fibroblasts and reactive oxygen species, mediated by TGF beta 1, allowing the development of antioxidant in the management of the established radiation-induced fibroatrophy. Cosmetic sequelae are evaluated with standardized scales, such as the LENT-SOMA and must be monitored during at least 5 years...
September 2012: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/22890802/3d-dosimetry-in-patients-with-early-breast-cancer-undergoing-intraoperative-avidination-for-radionuclide-therapy-iart-combined-with-external-beam-radiation-therapy
#19
COMPARATIVE STUDY
Mahila E Ferrari, Marta Cremonesi, Amalia Di Dia, Francesca Botta, Concetta De Cicco, Anna Sarnelli, Piernicola Pedicini, Michele Calabrese, Roberto Orecchia, Guido Pedroli, Giovanni Paganelli
PURPOSE: Intraoperative Avidination for Radionuclide Therapy (IART) is a novel targeted radionuclide therapy recently used in patients with early breast cancer. It is a radionuclide approach with (90)Y-biotin combined with external beam radiotherapy (EBRT) to release a boost of radiation in the tumour bed. Two previous clinical trials using dosimetry based on the calculation of mean absorbed dose values with the hypothesis of uniform activity distribution (MIRD 16 method) assessed the feasibility and safety of IART...
November 2012: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/22310324/-assessing-the-contribution-of-a-standardized-method-in-defining-the-tumor-bed-using-surgical-clips-in-breast-cancer
#20
S Thureau, S Oden, R Mokaouim, S Mezzani-Saillard, F Clatot, C Hanzen
PURPOSE OF THE STUDY: The objective of this study was to compare prospectively the delineations of tumour bed after breast conserving surgery from two techniques for defining the target volume. PATIENTS AND METHODS: Sixteen patients treated by lumpectomy with development of surgical clips were included. For each patient, four radiation oncologists delineated the clinical target volume (CTV boost) following its own method (technique 1) or using a predefined methodology (technique 2), the diameter to be applied around each clip relative to the risk of local recurrence...
April 2012: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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