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https://www.readbyqxmd.com/read/28545178/hylan-gf-20-viscosupplementation-in-the-treatment-of-symptomatic-osteoarthritis-of-the-knee-clinical-effect-survivorship-at-5-years
#1
Tarek Boutefnouchet, Guru Puranik, Esther Holmes, Karl M Bell
Purpose: Controversies remain surrounding the choice of hyaluronic acid products and patient selection. A study was conducted to report the long-term survivorship of intra-articular injection effect of high molecular weight hyaluronic preparation hylan GF-20 (Synvisc-One) for patients with symptomatic knee osteoarthritis. Materials and Methods: A retrospective observational analysis of a single therapeutic series was carried out. The analysis was conducted to determine therapeutic effect survivorship taking arthroplasty and any other surgical interventions as endpoint results...
June 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28487266/assessing-the-impact-of-a-novel-smartphone-application-compared-with-standard-follow-up-on-mobility-of-patients-with-knee-osteoarthritis-following-treatment-with-hylan-g-f-20-a-randomized-controlled-trial
#2
Nebojsa Skrepnik, Andrew Spitzer, Roy Altman, John Hoekstra, John Stewart, Richard Toselli
BACKGROUND: Osteoarthritis (OA) is a leading cause of disability in the United States. Although no disease-modifying therapies exist, patients with knee OA who increase walking may reduce risk of functional limitations. OBJECTIVE: The objective of the study is to evaluate the impact of a mobile app (OA GO) plus wearable activity monitor/pedometer (Jawbone UP 24) used for 90 days on the mobility of patients with knee OA treated with hylan G-F 20. METHODS: Patients with knee OA aged 30 to 80 years who were eligible to receive hylan G-F 20 and were familiar with smartphone technology were enrolled in this randomized, multicenter, open-label study...
May 9, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28465993/right-ventricular-outflow-tract-systolic-excursion-and-fractional-shortening-can-these-echocardiographic-parameters-be-used-for-the-assessment-of-right-ventricular-function
#3
Lamyaa Elsayed Allam, Ahmed Mohammed Onsy, Hylan Ahmed Ghalib
BACKGROUND: Echocardiographic right ventricular (RV) function assessment is difficult and still a gray area despite rapid advancement of imaging modalities. The aim of this study is to assess the role of echocardiographic RV outflow tract (RVOT) function in the form of RVOT fractional shortening (RVOT FS) and RVOT systolic excursion (RVOT SE) for the assessment of RV function. METHODS: We studied ninety individuals divided equally into two groups. The control group included 45 normal healthy individuals and age-matched patient group included 45 patients with RV dysfunction which was defined by tricuspid annular plane systolic excursion (TAPSE) <16 mm and RV fractional area change (RV FAC) ≤35%...
April 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/28092250/-osteoarthrosis-implementation-of-current-diagnostic-and-therapeutic-algorithms
#4
Gilberto Meza-Reyes, Jorge Aldrete-Velasco, Rolando Espinosa-Morales, Fernando Torres-Roldán, Alejandro Díaz-Borjón, Manuel Robles-San Román
In the modern world, among the different clinical presentations of osteoarthritis, gonarthrosis and coxarthrosis exhibit the highest prevalence. In this paper, the characteristics of osteoarthritis and the different scales of assessment and classification of this pathology are exposed, to provide an exhibition of current evidence generated around diagnostic algorithms and treatment of osteoarthritis, with emphasis set out in the knee and hip, as these are the most frequent; a rational procedure for monitoring patients with osteoarthritis based on characteristic symptoms and the severity of the condition is also set...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27867433/open-label-study-of-initial-and-repeat-treatment-cycles-of-hylan-g-f-20-in-patients-with-symptomatic-knee-osteoarthritis
#5
Robert Heger, Günther Paulsen, Ulrich Fickert, Michael Kresmann
OBJECTIVE: To evaluate the efficacy and safety of initial and repeat treatment with hylan G-F 20 in patients with symptomatic osteoarthritis (OA) of the knee. METHODS: A prospective, multicenter, open-label study in adult patients with symptomatic knee OA (Kellgren-Lawrence grades I-III) undergoing repeat (SC group) or initial (IC group) treatment courses (3 x 2 mL of hylan G-F 20 at weekly intervals) was conducted with a maximum follow-up of 26 weeks. Reduction of pain using the Verbal Pain Questionnaire (VPQ) and Patient Global Assessment (PTGA) scores, concomitant pain medications use, and adverse events (AEs) were evaluated...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27860135/joint-lavage-followed-by-viscosupplementation-and-triamcinolone-in-patients-with-severe-haemophilic-arthropathy-objective-functional-results
#6
M U Rezende, F R Andrusaitis, R T Silva, E Okazaki, J D A Carneiro, G C Campos, A F Pailo, R Frucchi, T Pasqualin, P R Villaça
INTRODUCTION: Viscosupplementation can improve function in haemophilia patients. Viscosupplementation results can be improved by prior joint lavage and triamcinolone administration. AIM: To objectively assess whether viscosupplementation and associated triamcinolone use in patients with severe haemophilic arthropathy following joint lavage improves force and balance and reduces bleeding events. METHODS: Fourteen patients with haemophilic knee arthritis with and without the involvement of other joints underwent joint lavage and subsequent injections of Hylan G-F20 and triamcinolone into all affected joints...
March 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27501653/anesthetic-considerations-of-stiff-person-syndrome-a-case-report
#7
REVIEW
Kristi Hylan, An-Duyen Nguyen Vu, Katherine Stammen
Stiff-person syndrome (SPS) is a neurologic disorder characterized by painful involuntary episodes of severe muscle rigidity affecting the axial muscles and extremities. Although the etiology of SPS is unknown, it is suspected to involve the synthesis of γ-aminobutyric acid (GABA). Symptoms of SPS are precipitated by sudden unexpected movements, noises, and stress. Additionally, SPS has been linked with various autoimmune disorders, including diabetes mellitus, thyroid disease, pernicious anemia, and certain cancers...
June 2016: AANA Journal
https://www.readbyqxmd.com/read/27435213/hylan-g-f-20-versus-low-molecular-weight-hyaluronic-acids-for-knee-osteoarthritis-a-meta-analysis
#8
COMPARATIVE STUDY
Hongmou Zhao, Hongliang Liu, Xiaojun Liang, Yi Li, Junhu Wang, Cheng Liu
BACKGROUND: Hyaluronic acid injection has been reported to decrease pain compared with baseline levels in knee joint osteoarthritis. Hylan G-F 20 is distinguished from the other products by its chemical structure and relatively higher molecular weight. Many trials have compared hylan G-F 20 and low molecular weight hyaluronic acids (LMWHAs); however, their relative efficacy and safety are still debated. OBJECTIVE: The aim was to compare the effectiveness and safety of intra-articular injection of hylan G-F 20 and LMWHA in the treatment of knee joint osteoarthritis...
October 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/27252444/utilizing-health-care-resources-wisely-understanding-the-efficacy-of-our-interventions-commentary-on-an-article-by-nattapol-tammachote-md-msc-et-al-intra-articular-single-shot-hylan-g-f-20-hyaluronic-acid-injection-compared-with-corticosteroid-in-knee-osteoarthritis
#9
COMMENT
https://www.readbyqxmd.com/read/27252432/intra-articular-single-shot-hylan-g-f-20-hyaluronic-acid-injection-compared-with-corticosteroid-in-knee-osteoarthritis-a-double-blind-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Nattapol Tammachote, Supakit Kanitnate, Thanasak Yakumpor, Phonthakorn Panichkul
BACKGROUND: The treatment of knee osteoarthritis with hyaluronic acid or corticosteroid injection has been widely used. The purpose of this study was to compare the efficacy of hyaluronic acid (hylan G-F 20) with triamcinolone acetonide as a single intra-articular injection for knee osteoarthritis. METHODS: This study was a prospective, randomized, double-blind clinical trial. Participants with symptomatic knee osteoarthritis were recruited. They were randomized to receive a single-shot, intra-articular injection of either 6 mL of hylan G-F 20 or 6 mL of a solution comprising 1 mL of 40-mg triamcinolone acetonide and 5 mL of 1% lidocaine with epinephrine...
June 1, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27118194/weekly-injections-of-hylan-g-f-20-delay-cartilage-degeneration-in-partial-meniscectomized-rat-knees
#11
Katsuaki Yanagisawa, Takeshi Muneta, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya
BACKGROUND: Cross-linked hyaluronan--also called Hylan G-F 20--is a medical device developed to treat osteoarthritis of the knee. However, it is still controversial whether Hylan G-F 20 has a cartilage protective effect in trauma-induced osteoarthritis. We investigated whether Hylan G-F 20 delayed osteoarthritis progression in a partial meniscectomized rat model. METHODS: Lewis rats were used for the experiments. The anterior medial meniscus was resected at the level of the medial collateral ligament in both knees...
April 27, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27071650/characterization-of-viscosupplementation-formulations-using-chemical-exchange-saturation-transfer-viscocest
#12
Mohammad Haris, Anup Singh, Sanjana Reddy, Puneet Bagga, J Bruce Kneeland, Fotios P Tjoumakaris, Hari Hariharan, Francesco M Marincola, Ravinder Reddy
BACKGROUND: Osteoarthritis (OA) is characterized by progressive loss of cartilage in joints, and is a major cause of pain and disability, and imposes significant health care expense. New therapies are being developed to treat the symptomatic effect of OA, one of which is intra-articular injection of viscosupplementations of different forms of hyaluronic acid (HA). The current study evaluates the chemical exchange saturation transfer (CEST) effect from two popular viscosupplementations [Hylan gf-20 (Synvisc) and hyaluronan (Orthovisc)] by targeting the exchangeable hydroxyl protons present on these molecules (ViscoCEST)...
April 12, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/26873037/oxidative-stress-and-histological-alterations-of-chicken-brain-induced-by-oral-administration-of-chromium-iii
#13
Jia Cheng, Wentao Fan, Xiaona Zhao, Yanhan Liu, Ziqiang Cheng, Yongxia Liu, Jianzhu Liu
This experiment was conducted to investigate the oxidative stress in chickens exposed to different concentrations of chromium trichloride (CrCl3) in drinking water. Seventy-two Hylan Brown male chickens were randomly divided into four groups: three experimental groups and one control group. The experimental groups were exposed to three different doses (50 % LD50, 25 % LD50, and 12.5 % LD50) of CrCl3 mg/kg body weight for 42 days, while the control group was given the equivalent water. The activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and non-enzymatic index (glutathione, total antioxidant capacity, malondialdehyde, and hydrogen peroxide) were measured after obtaining the brain samples...
September 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/26666513/cartilage-boundary-lubrication-synergism-is-mediated-by-hyaluronan-concentration-and-prg4-concentration-and-structure
#14
Taryn E Ludwig, Miles M Hunter, Tannin A Schmidt
BACKGROUND: Proteoglycan 4 (PRG4) and hyaluronan (HA) are key synovial fluid constituents that contribute synergistically to cartilage boundary lubrication; however, the effects of their concentrations as well as their structure, both of which can be altered in osteoarthritis, on this functional synergism are unknown. The objectives of this study were to evaluate cartilage boundary lubricating ability of 1) PRG4 + HA in solution at constant HA concentration in a range of PRG4 concentrations, 2) constant PRG4 concentration in a range of HA concentrations, 3) HA + reduced/alkylated (R/A) PRG4, and 4) hylan G-F 20 + PRG4...
2015: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26533632/the-effectiveness-and-cost-effectiveness-of-hylan-g-f-20-in-osteoarthritis-of-the-knee
#15
A Kostyuk, A Almadiyeva, A Akanov
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26508838/pain-relief-and-improved-physical-function-in-knee-osteoarthritis-patients-receiving-ongoing-hylan-g-f-20-a-high-molecular-weight-hyaluronan-versus-other-treatment-options-data-from-a-large-real-world-longitudinal-cohort-in-canada
#16
COMPARATIVE STUDY
Robert J Petrella, Craig Wakeford
From the Southwestern Ontario database, one of the largest primary-care datasets in Canada, 1,263 patients with osteoarthritis (OA) of one or both knees were identified who received two consecutive series of intra-articular (IA) injections of hylan G-F 20 preparation and no other prescribed OA medications, and were evaluated fully between 2006 and 2012. A cohort of 3,318 demographically matched OA patients who had not been treated with IA injection therapy was identified from the same database for comparison...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26456569/using-natural-language-processing-to-identify-problem-usage-of-prescription-opioids
#17
David S Carrell, David Cronkite, Roy E Palmer, Kathleen Saunders, David E Gross, Elizabeth T Masters, Timothy R Hylan, Michael Von Korff
BACKGROUND: Accurate and scalable surveillance methods are critical to understand widespread problems associated with misuse and abuse of prescription opioids and for implementing effective prevention and control measures. Traditional diagnostic coding incompletely documents problem use. Relevant information for each patient is often obscured in vast amounts of clinical text. OBJECTIVES: We developed and evaluated a method that combines natural language processing (NLP) and computer-assisted manual review of clinical notes to identify evidence of problem opioid use in electronic health records (EHRs)...
December 2015: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/26388558/hylan-g-f-20-attenuates-posttraumatic-osteoarthritis-progression-association-with-upregulated-expression-of-the-circardian-gene-npas2
#18
Chih-Chung Liu, Li-Jen Su, Wei-Yuan Tsai, Hsiao-Lun Sun, Hoong-Chien Lee, Chih-Shung Wong
AIMS: The study was to examine the effect of Hylan G-F 20 on the progression of posttraumatic osteoarthritis (PTOA) and the expression of the circadian genes neuronal PAS domain protein 2 (NPAS2) and period 2 (Per2). MAIN METHODS: We used the anterior cruciate ligament transaction and medial menisectomy (ACLT+MMx) model in Wistar rats. The rats were divided into three groups, the sham-operated group, the Hylan G-F 20-treated group, and the saline-treated group. Rats which underwent ACLT + MMx surgery were injected intraarticularly with, respectively, Hylan G-F 20 or saline once a week for 3 consecutive weeks, starting 7days after surgery...
November 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/26257790/alterations-in-the-secretome-of-clinically-relevant-preparations-of-adipose-derived-mesenchymal-stem-cells-cocultured-with-hyaluronan
#19
Peter Succar, Edmond J Breen, Donald Kuah, Benjamin R Herbert
Osteoarthritis (OA) can be a debilitating degenerative disease and is the most common form of arthritic disease. There is a general consensus that current nonsurgical therapies are insufficient for younger OA sufferers who are not candidates for knee arthroplasties. Adipose-derived mesenchymal stem cells (MSCs) therapy for the treatment of OA can slow disease progression and lead to neocartilage formation. The mechanism of action is secretion driven. Current clinical preparations from adipose tissue for the treatment of OA include autologous stromal vascular fraction (SVF), SVF plus mature adipocytes, and culture-purified MSCs...
2015: Stem Cells International
https://www.readbyqxmd.com/read/26207096/subjective-results-of-joint-lavage-and-viscosupplementation-in-hemophilic-arthropathy
#20
Márcia Uchoa de Rezende, Thiago Bittencourt Carvalho Rosa, Thiago Pasqualin, Renato Frucchi, Erica Okazaki, Paula Ribeiro Villaça
OBJECTIVE: To assess whether joint lavage, viscosupplementation and triamcinolone improve joint pain, function and quality of life in patients with severe hemophilic arthropathy. METHODS: Fourteen patients with knee and/or ankle hemophilic arthritis with and without involvement of other joints underwent joint lavage and subsequent injection of hylan G-F20 and triamcinolone in all affected joints. The patients answered algo-functional questionnaires (Lequesne and WOMAC), visual analog scale for pain (VAS) and SF-36 preoperatively, and at one, three, six and twelve months postoperatively...
May 2015: Acta Ortopedica Brasileira
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