keyword
https://read.qxmd.com/read/38533619/amyloid-pathology-mediates-the-associations-between-plasma-fibrinogen-and-cognition-in-non-demented-adults
#21
JOURNAL ARTICLE
Li-Yun Ma, Jing-Hui Song, Pei-Yang Gao, Ya-Nan Ou, Yan Fu, Liang-Yu Huang, Zuo-Teng Wang, Dan-Dan Zhang, Rui-Ping Cui, Yin-Chu Mi, Lan Tan
Though previous studies revealed the potential associations of elevated levels of plasma fibrinogen with dementia, there is still limited understanding regarding the influence of Alzheimer's disease (AD) biomarkers on these associations. We sought to investigate the interrelationships among fibrinogen, cerebrospinal fluid (CSF) AD biomarkers, and cognition in non-demented adults. We included 1996 non-demented adults from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study and 337 from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database...
March 27, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38533271/erratum-to-association-between-modifiable-risk-factors-and-levels-of-blood-based-biomarkers-of-alzheimer-s-and-related-dementias-in-the-look-ahead-cohort
#22
K M Hayden, M M Mielke, J K Evans, R Neiberg, D Molina-Henry, M Culkin, S Marcovina, K C Johnson, O T Carmichael, S R Rapp, B C Sachs, J Ding, H Shappell, L Wagenknecht, J A Luchsinger, M A Espeland
[This corrects the article DOI: 10.14283/jarlife.2024.1.].
2024: JAR Life
https://read.qxmd.com/read/38533051/therapeutic-potential-of-clinically-proven-natural-products-in-the-management-of-dementia
#23
REVIEW
Farzana Ansari, Md Sohel, Md Mahfujul Haque Haidary, Md Saqline Mostaq, Shamima Akter, Asrafun Nahar, Fatematuz Zohora Labony, Arman Ahmed, Mohammed Shamim Hasan, Mohammad Hasem Babu, Mohammad Nurul Amin
Dementia is a common neurodegenerative disorder connected to damage to nerve cells in the brain. Although some conventional drugs are available for dementia treatments and are still sanctified for dementia patients, their short- and long-term side effects and other limitations make treating patients more challenging. The authors aimed to explain novel options for treating dementia with natural products and unravel some clinically proven natural products. This article systematically reviewed recent studies that have investigated the role of natural products and their bioactive compounds for dementia...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532827/biomarkers-of-chronic-inflammation-and-cognitive-decline-a-prospective-observational-study
#24
JOURNAL ARTICLE
Bhavna A Guduguntla, Alexi Vasbinder, Elizabeth Anderson, Tariq U Azam, Pennelope Blakely, Noah J Webster, Richard Gonzalez, Toni Atonucci, Judith L Heidebrink, Bruno Giordani, Laura Zahodne, Benjamin M Hampstead, Kristine J Ajrouch, Salim S Hayek
We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C-reactive protein (hs-CRP) levels in 282 participants of the University of Michigan Memory and Aging Project. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Clinical Dementia Rating (CDR) scale for up to five time points. SuPAR and hs-CRP levels were not significantly higher in participants with mild cognitive impairment ( n  = 97) or dementia ( n  = 59), compared to those with normal cognitive function ( n  = 126)...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38532623/importance-of-patient-and-public-involvement-in-doctoral-research-involving-people-living-with-dementia
#25
JOURNAL ARTICLE
Cathryn Smith, Jessica Baillie, Paul Gill
BACKGROUND: There is increasing recognition of the need to include patients and the public in the research process. There is extensive literature about patient and public involvement (PPI) in research, but fewer articles report on PPI in doctoral research. AIM: To reflect on establishing an advisory group for a doctoral study, exploring the opportunities and challenges associated with including patients with dementia in the research process. DISCUSSION: The authors discuss the practicalities of establishing an advisory group, the challenges of being a novice researcher, long-term commitment to PPI, the overall approach to PPI and ethical considerations...
March 27, 2024: Nurse Researcher
https://read.qxmd.com/read/38532522/donepezil-induced-bradycardia-in-a-schizophrenic-patient-with-comorbid-neurocognitive-disorder-a-case-report-and-review-of-the%C3%A2-literature
#26
JOURNAL ARTICLE
Nkolika Odenigbo, Stanley Nkemjika, Ayodele Atolagbe, Christian Nwabueze, Connie Olwit, Jeffery Lawrence, Tolulope Olupona
BACKGROUND: Trials of cholinergic and glutamatergic agents have improved cognition and memory for the geriatric schizophrenic population. Donepezil is an acetylcholinesterase inhibitor that improves cognition by preventing postsynaptic degradation of hippocampal acetylcholine in patients with mild-to-moderate dementia. Donepezil has been attributed to some adverse effects, especially gastrointestinal symptoms. However, cardiovascular adverse effects are not common as there remains a dearth of literature regarding donepezil-induced bradycardia...
March 27, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38532365/study-protocol-randomized-controlled-trial-of-an-individualized-music-intervention-for-people-with-dementia-in-the-home-care-setting
#27
JOURNAL ARTICLE
Elisabeth Jakob, Juliane Meininger, Mareike Hillebrand, Lisette Weise, Gabriele Wilz
BACKGROUND: Studies suggest that individualized music listening is an effective, non-pharmacological intervention for improving the quality of life of people with dementia in the institutional care setting. Noting that most people with dementia live at home, we conduct a randomized controlled trial to assess the feasibility and effectiveness of an app-based individualized music listening intervention for people with dementia in the home care setting. The intervention is delivered by family caregivers...
March 26, 2024: BMC Psychiatry
https://read.qxmd.com/read/38532163/a-test-for-alzheimer-s-disease-stage-predicts-dementia-risk
#28
(no author information available yet)
No abstract text is available yet for this article.
March 26, 2024: Nature
https://read.qxmd.com/read/38531956/darier-disease-is-associated-with-neurodegenerative-disorders-and-epilepsy
#29
JOURNAL ARTICLE
Philip Curman, William Jebril, Henrik Larsson, Etty Bachar-Wikstrom, Martin Cederlöf, Jakob D Wikstrom
Darier disease (DD) is a rare monogenetic skin disorder with limited data on its potential association with neurological disorders. This study aimed to investigate the association between DD and neurological disorders, specifically Parkinson's disease, dementias, and epilepsy. Using Swedish national registers in a period spanning between 1977 and 2013, 935 individuals with DD were compared with up to 100 comparison individuals each, randomly selected from the general population based on birth year, sex, and county of residence at the time of the first diagnosis of DD...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531951/interrogation-of-the-human-cortical-peptidome-uncovers-cell-type-specific-signatures-of-cognitive-resilience-against-alzheimer-s-disease
#30
JOURNAL ARTICLE
G R Morgan, B C Carlyle
Alzheimer's disease (AD) is characterised by age-related cognitive decline. Brain accumulation of amyloid-β plaques and tau tangles is required for a neuropathological AD diagnosis, yet up to one-third of AD-pathology positive community-dwelling elderly adults experience no symptoms of cognitive decline during life. Conversely, some exhibit chronic cognitive impairment in absence of measurable neuropathology, prompting interest into cognitive resilience-retained cognition despite significant neuropathology-and cognitive frailty-impaired cognition despite low neuropathology...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531900/spatial-transcriptomics-reveals-molecular-dysfunction-associated-with-cortical-lewy-pathology
#31
JOURNAL ARTICLE
Thomas M Goralski, Lindsay Meyerdirk, Libby Breton, Laura Brasseur, Kevin Kurgat, Daniella DeWeerd, Lisa Turner, Katelyn Becker, Marie Adams, Daniel J Newhouse, Michael X Henderson
A key hallmark of Parkinson's disease (PD) is Lewy pathology. Composed of α-synuclein, Lewy pathology is found both in dopaminergic neurons that modulate motor function, and cortical regions that control cognitive function. Recent work has established the molecular identity of dopaminergic neurons susceptible to death, but little is known about cortical neurons susceptible to Lewy pathology or molecular changes induced by aggregates. In the current study, we use spatial transcriptomics to capture whole transcriptome signatures from cortical neurons with α-synuclein pathology compared to neurons without pathology...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531892/treadmill-exercise-pretreatment-ameliorated-structural-synaptic-plasticity-impairments-of-medial-prefrontal-cortex-in-vascular-dementia-rat-and-improved-recognition-memory
#32
JOURNAL ARTICLE
Linlin Zhang, Yuanyuan Chen, Yongzhao Fan, Lin Shi
This study aimed to investigate structural synaptic plasticity in the medial prefrontal cortex of rats under treadmill exercise pretreatment or naive conditions in a vascular dementia model, followed by recognition memory performance in a novel object recognition task. In this study, 24 Sprague-Dawley rats were obtained and randomly assigned into 4 groups as follows: control group (Con group, n = 6), vascular dementia (VD group, n = 6), exercise and vascular dementia group (Exe + VD group, n = 6), and exercise group (Exe group, n = 6)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531695/increased-trend-in-dementia-incidence-within-a-taiwanese-national-cohort-what-have-we-learned-what-can-we-do
#33
EDITORIAL
Davide Angioni, Pierre-Jean Ousset, Bruno Vellas
No abstract text is available yet for this article.
March 16, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38531675/development-and-internal-validation-of-a-dynamic-fall-risk-prediction-and-monitoring-tool-in-aged-care-using-routinely-collected-electronic-health-data-a-landmarking-approach
#34
JOURNAL ARTICLE
Nasir Wabe, Isabelle Meulenbroeks, Guogui Huang, Sandun Malpriya Silva, Leonard C Gray, Jacqueline C T Close, Stephen Lord, Johanna I Westbrook
OBJECTIVES: Falls pose a significant challenge in residential aged care facilities (RACFs). Existing falls prediction tools perform poorly and fail to capture evolving risk factors. We aimed to develop and internally validate dynamic fall risk prediction models and create point-based scoring systems for residents with and without dementia. MATERIALS AND METHODS: A longitudinal cohort study using electronic data from 27 RACFs in Sydney, Australia. The study included 5492 permanent residents, with a 70%-30% split for training and validation...
March 26, 2024: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38531510/age-related-changes-in-species-typical-behaviours-in-the-5xfad-mouse-model-of-alzheimer-s-disease-from-4-16-months-of-age
#35
JOURNAL ARTICLE
Timothy P O'Leary, Richard E Brown
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform activities of daily living and the decline in these activities is related to the severity of neurobiological deterioration underlying the disease. The 5xFAD mouse model of AD shows age-related impairments in sensory- motor and cognitive function, but little is known about changes in species-typical behaviours that may model activities of daily living in AD patients. Therefore, we examined species-typical behaviours used as indices of exploration (rearing) and compulsivity (grooming) across six tests of anxiety-like behaviour or motor function in female 5xFAD mice from 3-16 months of age...
March 24, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38531337/informal-care-time-and-costs-of-dementia-care-in-benin-west-africa
#36
JOURNAL ARTICLE
Angeladine Kenne Malaha, Clémence Thébaut, Dismand Stephan Houinato, Grégoire Magloire Gansou, Dieu Donné Gnonlonfoun, Thierry Adoukonou, Pierre-Marie Preux, Maëlenn Guerchet
BACKGROUND: Dementia is a growing global health challenge, with significant socioeconomic implications. This study examined the informal care duration and related costs along with the total cost of care for older individuals with dementia in Benin, West Africa, providing insights into a region with limited dementia research. METHODS: We conducted a cost-of-illness study in Benin. Both hospital and community recruitments were used to enroll adults aged ≥ 60 years and their primary caregivers...
March 26, 2024: Neuroepidemiology
https://read.qxmd.com/read/38531336/physical-activity-moderates-the-relationship-between-cardiovascular-disease-risk-burden-and-cognition-in-older-adults
#37
JOURNAL ARTICLE
Sandra T Nguyen, Jing Guo, Suhang Song, Dolly Reyes-Dumeyer, Danurys Sanchez, Adam M Brickman, Jennifer J Manly, Nicole Schupf, Rafael A Lantigua, Richard P Mayeux, Yian Gu
Introduction Older individuals with higher cardiovascular disease (CVD) burden have a higher risk for accelerated cognitive decline and dementia. Physical activity (PA) is an inexpensive and accessible preventive measure to CVD, cognitive impairment, and dementia. The current study examined (1) whether PA moderates the relationship between CVD burden and cognition and (2) whether the moderating effect of PA differs by race/ethnicity groups and by APOE-ɛ4 status. Methods Our cross-sectional study included participants from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a multi-ethnic, community-based, longitudinal study on aging and dementia among individuals aged 65 years and older who reside in northern Manhattan...
March 26, 2024: Neuroepidemiology
https://read.qxmd.com/read/38531174/effect-of-increasing-cognitive-activity-participation-on-default-mode-network-in-older-adults-with-subjective-cognitive-decline-a-randomised-controlled-trial
#38
JOURNAL ARTICLE
Allen Ting Chun Lee, Yishan Luo, Zhaohua Huo, Lin Shi, Winnie Chiu Wing Chu, Linda Chiu Wa Lam
BACKGROUND: Having more cognitive activities may prevent dementia, but its evidence of modulating the functional brain network is limited. This randomised controlled trial (RCT) investigated the effect of increased cognitive activity participation on the default mode network (DMN) in older adults who had already been having regular cognitive activity participation and experiencing subjective cognitive decline (SCD). METHODS: Community-living Chinese individuals aged 55-75 years with regular practice of Chinese calligraphy and screened positive for SCD (but negative for mild cognitive impairment or dementia) were randomly allocated to either the intervention or control group...
March 25, 2024: EBioMedicine
https://read.qxmd.com/read/38531149/the-social-and-cognitive-online-training-scot-project-a-digital-randomized-controlled-trial-to-promote-socio-cognitive-well-being-in-older-adults
#39
JOURNAL ARTICLE
Giulia Funghi, Claudia Meli, Arianna Cavagna, Lisa Bisoffi, Francesca Zappini, Costanza Papagno, Alessandra Dodich
OBJECTIVES: Effective prevention programs targeting risk factors for cognitive decline in the elderly are recommended given the progressive increase in the aging of the general population. The Social and Cognitive Online Training (SCOT) project is a randomized, controlled, parallel clinical trial designed to prevent the age-related decline in executive and social functions. METHODS: The study included 60 cognitively healthy older adults (age = 71.8±5.3, education = 12...
March 5, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38530880/glucosylceramide-accumulation-in-microglia-triggers-sting-dependent-neuroinflammation-and-neurodegeneration-in-mice
#40
JOURNAL ARTICLE
Rui Wang, Hongyang Sun, Yifan Cao, Zhixiong Zhang, Yajing Chen, Xiying Wang, Lele Liu, Jin Wu, Hao Xu, Dan Wu, Chenchen Mu, Zongbing Hao, Song Qin, Haigang Ren, Junhai Han, Ming Fang, Guanghui Wang
Mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo...
March 26, 2024: Science Signaling
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