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https://www.readbyqxmd.com/read/27933755/maternal-pre-pregnancy-bmi-downregulates-neonatal-cord-blood-lep-methylation
#1
R Kadakia, Y Zheng, Z Zhang, W Zhang, L Hou, J L Josefson
BACKGROUND: Neonatal adiposity has many determinants and may be a risk factor for future obesity. Epigenetic regulation of metabolically important genes is a potential contributor. OBJECTIVES: The objective of the study is to determine whether methylation changes in the LEP gene in cord blood DNA are impacted by the maternal environment or affect neonatal adiposity measures. METHODS: A cross-sectional study of 114 full-term neonates born to healthy mothers with normal glucose tolerance was performed...
December 8, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27933735/danazol-has-potential-to-cause-pkc-translocation-cell-cycle-dysregulation-and-apoptosis-in-breast-cancer-cells
#2
Suman Jyoti Deka, Ashalata Roy, Vibin Ramakrishnan, Debasis Manna, Vishal Trivedi
Danazol, the established clinical drug has given promising therapeutic results in a series of clinical trials with breast cancer patients. Danazol shares structural similarities with several known PKC agonists and fits well into the C1 domain. Danazol binds to the C1b domain of PKC with Kd of 5.64±1.27 μM. MD simulation studies further support that the PKC-Danazol molecular model is stable and showing minimum distortion to the structure during the simulation period. Immunofluorescence and western-blotting studies indicate that MDAMB-231 cells stimulated with danazol exhibit translocation of PKCα to the plasma membrane...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27933733/mannich-bases-of-1-2-4-triazole-3-thione-containing-adamantane-moiety-synthesis-preliminary-anticancer-evaluation-and-molecular-modeling-studies
#3
Milorad Z Milošev, Katarina Jakovljević, Milan D Joksović, Tatjana Stanojković, Ivana Z Matić, Milka Perović, Vesna Tešić, Selma Kanazir, Milan Mladenović, Marko V Rodić, Vukadin M Leovac, Snežana Trifunović, Violeta Marković
A series of 18 novel N-Mannich bases derived from 5-adamantyl-1,2,4-triazole-3-thione was synthesized and characterized using NMR spectroscopy and X-ray diffraction technique. All derivatives were evaluated for their anticancer potential against four human cancer cell lines. Several tested compounds exerted good cytotoxic activities on K562 and HL-60 cell lines, along with pronounced selectivity, showing lower cytotoxicity against normal fibroblasts MRC-5 compared to cancer cells. The effects of compounds 5b, 5e and 5j on the cell cycle were investigated by flow cytometric analysis...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27933728/sequential-change-detection-and-monitoring-of-temporal-trends-in-random-effects-meta-analysis
#4
Samson Henry Dogo, Allan Clark, Elena Kulinskaya
Temporal changes in magnitude of effect sizes reported in many areas of research are a threat to the credibility of the results and conclusions of meta-analysis. Numerous sequential methods for meta-analysis have been proposed to detect changes and monitor trends in effect sizes so that meta-analysis can be updated when necessary and interpreted based on the time it was conducted. The difficulties of sequential meta-analysis under the random-effects model are caused by dependencies in increments introduced by the estimation of the heterogeneity parameter τ(2) ...
December 8, 2016: Research Synthesis Methods
https://www.readbyqxmd.com/read/27933726/inheritance-of-evolved-clethodim-resistance-in-lolium-rigidum-populations-from-australia
#5
Rupinder Kaur Saini, Jenna Malone, Gurjeet Gill, Christopher Preston
BACKGROUND: In Australia, the extensive use of clethodim for the control of Lolium rigidum has resulted in the evolution of many clethodim-resistant L.rigidum populations. Five clethodim-resistant populations of L. rigidum were analysed for the inheritance of clethodim resistance. RESULTS: Reciprocal crosses were made between resistant (R) and susceptible (S) populations. Within crosses, dose responses of reciprocal F1 families of all populations, except A61 were similar each other, indicating clethodim resistance in these populations is encoded on the nuclear genome...
December 8, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27933721/shared-molecular-networks-in-orofacial-and-neural-tube-development
#6
Youssef A Kousa, Tamer A Mansour, Haitham Seada, Samaneh Matoo, Brian C Schutte
BACKGROUND: Single genetic variants can affect multiple tissues during development. Thus it is possible that disruption of shared gene regulatory networks might underlie syndromic presentations. In this study, we explore this idea through examination of two critical developmental programs that control orofacial and neural tube development and identify shared regulatory factors and networks. Identification of these networks has the potential to yield additional candidate genes for poorly understood developmental disorders and assist in modeling and perhaps managing risk factors to prevent morbidly and mortality...
December 9, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27933701/ccr2-mediates-helicobacter-pylori-induced-immune-tolerance-and-contributes-to-mucosal-homeostasis
#7
Xia Sun, Min Zhang, Mohamad El-Zaatari, Gray B Huffnagle, John Y Kao
BACKGROUND: We previously demonstrated that H. pylori infection leads to increased induction of regulatory T cells in local and systemic immune compartments. Here, we investigate the role of CCR2 in the tolerogenic programing of dendritic cells in a mouse model of H. pylori infection. MATERIALS AND METHODS: CCR2 deficient (CCR2KO) mice and wild-type (Wt) mice infected with H. pylori SS1 strain were analyzed by qPCR and FACS analysis. In vitro, bone marrow-derived DC on day 6 from CCR2KO and Wt mice cocultured with or without H...
December 8, 2016: Helicobacter
https://www.readbyqxmd.com/read/27933681/evaluating-a-primary-care-psychology-service-in-ireland-a-survey-of-stakeholders-and-psychologists
#8
Mark Corcoran, Michael Byrne
Primary care psychology services (PCPS) represent an important resource in meeting the various health needs of our communities. This study evaluated the PCPS in a two-county area within the Republic of Ireland. The objectives were to (i) examine the viewpoints of the service for both psychologists and stakeholders (healthcare professionals only) and (ii) examine the enactment of the stepped care model of service provision. Separate surveys were sent to primary care psychologists (n = 8), general practitioners (GPs; n = 69) and other stakeholders in the two counties...
December 8, 2016: Health & Social Care in the Community
https://www.readbyqxmd.com/read/27933680/primary-breast-angiosarcoma-a-retrospective-study-of-36-cases-from-a-single-chinese-medical-institute-with-clinicopathologic-and-radiologic-correlations
#9
Lei Wang, I Weng Lao, Lin Yu, Wentao Yang, Jian Wang
The aim of this study was to present our experience with primary breast angiosarcoma (PBA) by describing a large series of cases with an emphasis on clinicopathologic and radiologic correlations. Thirty-six cases of PBA diagnosed at our institution between 2006 and 2014 were retrospectively evaluated. All but one case occurred in women with a median age of 35.5 years. The majority of patients presented with a deeply located painless mass, whereas a minority manifested as diffuse enlargement or swelling of the breast...
December 9, 2016: Breast Journal
https://www.readbyqxmd.com/read/27933676/white-matter-hyperintensities-are-associated-with-disproportionate-progressive-hippocampal-atrophy
#10
Cassidy M Fiford, Emily N Manning, Jonathan W Bartlett, David M Cash, Ian B Malone, Gerard R Ridgway, Manja Lehmann, Kelvin K Leung, Carole Sudre, Sebastien Ourselin, Geert Jan Biessels, Owen T Carmichael, Nick C Fox, M Jorge Cardoso, Josephine Barnes
This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 Mild Cognitive Impairment (MCI) and 154 AD subjects with serial volumetric 1.5T MRI. CSF Aβ42 and total tau were measured (n=353). Brain and hippocampal loss were quantified from serial MRI using the Boundary Shift Integral (BSI). Multiple linear regression models assessed the relationships between WMHs and hippocampal and brain atrophy rates...
December 9, 2016: Hippocampus
https://www.readbyqxmd.com/read/27933670/gold-i-fluorohalides-theory-and-experiment
#11
Babil Menjón, Miguel Baya, Alberto Pérez-Bitrián, Sonia Martínez-Salvador, José María Casas, Jesús Orduna
The anionic trifluoromethyl-gold(I) derivatives [CF₃AuX]⁻, which have been prepared and isolated as their [PPh₄]⁺ salts in good yield, undergo thermally-induced difluorocarbene extrusion in the gas phase giving rise to the mixed gold(I) fluorohalide complexes [F-Au-X]⁻ (X = Cl, Br, I). These triatomic species have been detected by tandem mass spectrometry (MS2) experiments and their properties have been analyzed by DFT methods. The CF₂ extrusion mechanism from the Au-CF₃ moiety serves as a model for the CF₂ insertion into the Au-F bond, since both reactivity channels are connected by the microreversibility principle...
December 9, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27933662/evidence-of-staphylococcus-aureus-deformation-proliferation-and-migration-in-canaliculi-of-live-cortical-bone-in-murine-models-of-osteomyelitis
#12
Karen L de Mesy Bentley, Ryan Trombetta, Kohei Nishitani, Sheila N Bello-Irizarry, Mark Ninomiya, Longze Zhang, Hung Li Chung, James L McGrath, John L Daiss, Hani A Awad, Stephen L Kates, Edward M Schwarz
While Staphylococcus aureus osteomyelitis is considered to be incurable, the major bacterial reservoir in live cortical bone has remained unknown. In addition to biofilm bacteria on necrotic tissue and implants, studies have implicated intracellular infection of osteoblasts and osteocytes as a mechanism of chronic osteomyelitis. Thus, we performed the first systematic transmission electron microscopy (TEM) studies to formally define major reservoirs of S. aureus in chronically infected mouse (Balb/c J) long bone tissue...
December 8, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27933657/analysis-of-temozolomide-resistance-in-low-grade-gliomas-by-using-a-mechanistic-mathematical-model
#13
Edouard Ollier, Pauline Mazzocco, Damien Ricard, Gentian Kaloshi, Ahmed Idbaih, Agusti Alentorn, Dimitri Psimaras, Jérôme Honnorat, Jean-Yves Delattre, Emmanuel Grenier, François Ducray, Adeline Samson
Understanding how tumours develop resistance to chemotherapy is a major issue in oncology. When treated with temozolomide (TMZ), an oral alkylating chemotherapy drug, most low-grade gliomas (LGG) show an initial volume decrease but this effect is rarely long lasting. In addition, it has been suggested that TMZ may drive tumour progression in a subset of patients as a result of acquired resistance. Using longitudinal tumour size measurements from 121 patients, the aim of the present study was to develop a semi-mechanistic mathematical model to determine whether resistance of LGG to TMZ was more likely to result from primary and/or from chemotherapy-induced acquired resistance that may contribute to tumour progression...
December 9, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27933637/association-of-temporal-variations-in-staffing-with-hospital-acquired-pressure-injury-in-military-hospitals
#14
Patricia A Patrician, Mary S McCarthy, Pauline Swiger, Dheeraj Raju, Sara Breckenridge-Sproat, Xiaogang Su, Kelly H Randall, Lori A Loan
To more precisely evaluate the effects of nurse staffing on hospital-acquired pressure injury (HAPI) development, data on nursing care hours per patient day (NCHPPD), nursing skill mix, patient turnover (i.e., admissions, transfers, and discharges), and patient acuity were merged with patient information from pressure injury prevalence surveys that were collected annually for the Military Nursing Outcomes Database (MilNOD) project. The MilNOD included staffing and adverse events from 56 medical-surgical, stepdown, and critical care units in 13 military hospitals over a 4-year-period...
December 9, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27933634/middle-cranial-fossa-approach-to-repair-tegmen-defects-assisted-by-three-dimensionally-printed-temporal-bone-models
#15
Sameer Ahmed, Kyle K VanKoevering, Stephanie Kline, Glenn E Green, H Alexander Arts
OBJECTIVES/HYPOTHESIS: To explore the perioperative utility of three-dimensionally (3D)-printed temporal bone models of patients undergoing repair of lateral skull base defects and spontaneous cerebrospinal fluid leaks with the middle cranial fossa approach. STUDY DESIGN: Case series. METHODS: 3D-printed temporal bone models-based on patient-specific, high-resolution computed tomographic imaging-were constructed using inexpensive polymer materials...
December 9, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27933633/discussion-of-a-risk-based-measure-of-time-varying-prognostic-discrimination-for-survival-models-by-c-jason-liang-and-patrick-j-heagerty
#16
Layla Parast, Carolyn M Rutter
No abstract text is available yet for this article.
December 8, 2016: Biometrics
https://www.readbyqxmd.com/read/27933613/rejoinder-to-discussions-on-a-risk-based-measure-of-time-varying-prognostic-discrimination-for-survival-models
#17
C Jason Liang, Patrick J Heagerty
No abstract text is available yet for this article.
December 8, 2016: Biometrics
https://www.readbyqxmd.com/read/27933612/discussion-of-a-risk-based-measure-of-time-varying-prognostic-discrimination-for-survival-models-by-c-jason-liang-and-patrick-j-heagerty
#18
H Michael, L Tian
No abstract text is available yet for this article.
December 8, 2016: Biometrics
https://www.readbyqxmd.com/read/27933610/resilience-mediates-impact-of-some-childhood-maltreatment-on-post-traumatic-stress-symptoms-in-conscripted-marines-in-the-republic-of-korea
#19
Heejung Kim, Sun Ah Kim, Seongsook Kong
Although it is known that post-traumatic stress symptoms (PTSS) can result from military service, the variance in PTSS unexplained by military service warrants further investigation, and no researchers have investigated South Korean Marines' vulnerability during their 2-year conscripted service as the first line of national defense against threats from North Korea. This study was designed to examine whether resilience mediated the relationship between childhood maltreatment and PTSS in 169 Korean conscripts into the Marine Corps...
December 9, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27933608/assessing-fear-learning-via-conditioned-respiratory-amplitude-responses
#20
Giuseppe Castegnetti, Athina Tzovara, Matthias Staib, Samuel Gerster, Dominik R Bach
Respiratory physiology is influenced by cognitive processes. It has been suggested that some cognitive states may be inferred from respiration amplitude responses (RAR) after external events. Here, we investigate whether RAR allow assessment of fear memory in cued fear conditioning, an experimental model of aversive learning. To this end, we built on a previously developed psychophysiological model (PsPM) of RAR, which regards interpolated RAR time series as the output of a linear time invariant system. We first establish that average RAR after CS+ and CS- are different...
December 8, 2016: Psychophysiology
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