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https://www.readbyqxmd.com/read/29670257/directed-reprogramming-of-comprehensively-characterized-dental-pulp-stem-cells-extracted-from-natal-tooth
#1
Rishikaysh V Pisal, Jakub Suchanek, Richard Siller, Tomas Soukup, Hana Hrebikova, Ales Bezrouk, David Kunke, Stanislav Micuda, Stanislav Filip, Gareth Sullivan, Jaroslav Mokry
The aim of this study was to extensively characterise natal dental pulp stem cells (nDPSC) and assess their efficiency to generate human induced pluripotent stem cells (hiPSC). A number of distinguishing features prompted us to choose nDPSC over normal adult DPSC, in that they differed in cell surface marker expression and initial doubling time. In addition, nDPSC expressed 17 out of 52 pluripotency genes we analysed, and the level of expression was comparable to human embryonic stem cells (hESC). Ours is the first group to report comprehensive characterization of nDPSC followed by directed reprogramming to a pluripotent stem cell state...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665928/-clinical-characteristics-treatment-and-prognosis-of-ptld-after-allogeneic-hematopoietic-stem-cell-transplantation
#2
Zhan-Xiang Liu, Wen-Rong Huang, Meng Li, Zhen-Yang Gu, Cheng-Ying Zhu, Ning Lu, Sheng Yao, Shu-Hong Wang, Fei Li, Xiao-Ning Gao, Dai-Hong Liu, Chun-Ji Gao
OBJECTIVE: To study the clinical characteristics of patients with post-transplantation lymphoproliferative disease (PTLD) after allogeneic peripheral blood hematopoietic stem cell transplantation, and to improve the understanding and diagnosis of PTLD. METHODS: The clinical data of 244 patients underwent allogeneic hematopoietic stem cell transplantation in the General Hospital of PLA from May 2014 to April 2017 were analyzed retrospectively. The follow-up time was up to November 30, 2017...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29494658/anti-epstein-barr-virus-antibodies-in-beijing-during-2013-2017-what-we-have-found-in-the-different-patients
#3
Jingtao Cui, Wenjuan Yan, Shaoxia Xu, Qiaofeng Wang, Weihong Zhang, Wenjing Liu, Anping Ni
BACKGROUND: Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC) which is prevalent in South China, and its association with systemic lupus erythematosus (SLE) or other autoimmune diseases has not been studied in the mainland of China. The EBV serological tests have been performed on patients with various diseases or manifestations for years at our institution and their values need to be evaluated. METHODS: For routine medical purposes, anti-EB viral capsid antigen (VCA) IgG, IgA and IgM antibodies, anti-EBV diffuse early antigen (EA-D) IgA antibodies, and anti-EBV nuclear antigen-1(EBNA-1) IgG antibodies were tested with commercial enzyme-linked immunosorbent assay (ELISA) in patients visiting Peking Union Medical College Hospital between 2013 and 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29397861/-research-progress-on-eb-virus-and-its-related-lymphoma-review
#4
Jing Zhou, Yi Xiao
Epstein-Barr virus(EBV) closely relates with the occurrence, development and prognosis of multiple lymphomas, such as Burkitt' s lymphoma, diffuse large B-cell lymphoma, Hodgkin' s lymphoma, angioimmunoblastic T cell lymphoma. The mechanism of EBV in tumorigenesis can be understanded through the research of EBV biological characteristics, EBV+ lymphoma and EBV- lymphoma. Based on traditional therapy, supplement of specific treatment for EBV, such as antiviral treatment, immunotherapy, can improve the curative rate of lymphoma...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29341283/mogamulizumab-induced-photosensitivity-in-patients-with-mycosis-fungoides-and-other-t-cell-neoplasms
#5
Y Masuda, K Tatsuno, S Kitano, H Miyazawa, J Ishibe, M Aoshima, T Shimauchi, T Fujiyama, T Ito, Y Tokura
BACKGROUND: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma. OBJECTIVE: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T-cell neoplasms after treatment with Mog. METHODS: We treated seven cutaneous lymphoma patients with Mog...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29338588/epstein-barr-virus-infection-and-type-i-interferon-signature-in-patients-with-systemic-lupus-erythematosus
#6
L Han, Y Zhang, Q Wang, M Xin, K Yang, K Lei, M Sun
Epstein-Barr (EB) virus infection has long been speculated to evoke systemic lupus erythematosus (SLE). Since a virus infection can induce interferon (IFN) system activation, we aimed to discover the relationship between the two in the progression of SLE in a Chinese inpatient cohort. Methods Peripheral blood mononuclear cells and sera were isolated from 116 SLE patients and 76 healthy controls. Antibodies against EBV-VCA (IgM and IgG) and EBNA (IgG) along with IFNα in patient sera were detected with enzyme-linked immunosorbent assays...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29325248/-survival-of-patients-with-primary-central-nervous-system-diffuse-large-b-cell-lymphoma-impact-of-gene-aberrations-and-protein-overexpression-of-bcl-2-and-c-myc-and-selection-of-chemotherapy-regimens
#7
W J Yin, X Zhu, H Y Yang, W Y Sun, M J Wu
Objective: To investigate the impact of clinicopathological features, gene rearrangements and protein expression of bcl-6, bcl-2, C-MYC and chemotherapy regime on the prognosis of patients with primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL). Methods: Thirty-three cases of PCNS-DLBCL diagnosed from January 2006 to December 2016 at Zhejiang Cancer Hospital were collected. The expression of CD10, bcl-6, bcl-2, MUM1 and MYC were detected by immunohistochemical staining (IHC). The presence of EB virus was detected by in situ hybridization(EBER)...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29262446/-diagnostic-value-of-narrow-band-imaging-in-detection-of-recurrent-nasopharyngeal-carcinoma
#8
J Y Si, J J Weng, B J Zhang, G P Lan, Y Yang, B Huang, Y L Wang, Y Qin, B Li, X Han, W M Xiong, Y F Si
Objective: To evaluate the diagnostic value and feasibility of narrow-band imaging in detection of recurrent nasopharyngeal carcinoma (NPC). Methods: One thousand three hundred and sixty-four NPC patients who had completed NPC treatment were enrolled. All patients were followed-up with imaging, serological examination of EB virus and nasopharyngeal endoscopy(WL and NBI mode), in which (1) both white light (WL) and NBI modes were done; (2) positive endoscopic patients were given nasopharyngeal biopsy; (3) using histologic finding as criterion standard, the sensitivity, specificity, accuracy and Yonden's index of two modes were compared...
December 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29177376/-detection-of-influenza-a-b-and-subtypes-a-h1n1-pdm09-a-h3n2-viruses-by-multiple-qrt-pcr-in-clinical-samples
#9
Pool Marcos, Maribel Huaringa, Nancy Rojas, Victoria Gutiérrez, Sila Ruiton, Emelda Gallardo, Jorge Achata, Marco Galarza
OBJECTIVES.: To describe the clinical and epidemiological characteristics of patients diagnosed with epidermolysis bullosa (EB) at the Instituto Nacional de Salud (INSN) in Lima, Peru; a National Reference Center for this disease. MATERIAL AND METHODS: . Observational, descriptive and transversal study. We reviewed the clinical histories and laboratory tests of patients diagnosed with EB treated in INSN from 1993 to 2015. RESULTS.: 93 patients were registered...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29164572/expression-of-glut-1-in-nasopharyngeal-carcinoma-and-its-clinical-significance
#10
J-C Zhou, J-J Zhang, W Zhang, Z-Y Ke, L-G Ma, M Liu
OBJECTIVE: To investigate the relationship between the expression of glucose transporter-1 (GLUT-1) and the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS: Sixty-three patients with NPC (the NPC group) and 24 patients with chronic nasopharyngitis (the control group) who were treated between December 2014 and February 2016 were selected for this study. Pathological nasopharyngeal tissues were collected from patients...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29110758/apol1-renal-risk-variants-fertile-soil-for-hiv-associated-nephropathy
#11
REVIEW
Jeffrey B Kopp, Jurgen Heymann, Cheryl A Winkler
Apolipoprotein L1 (APOL1) genetic variants are potent risk factors for glomerular disease, but one or more additional factors are required for expression of glomerular disease. Uncontrolled or poorly controlled human immunodeficiency virus (HIV) infection is the most potent susceptibility factor for APOL1 nephropathy that has been identified to date. APOL1 variants are associated with HIV-associated nephropathy (HIVAN), a podocyte disease, but not with HIV-immune complex disease, primarily a disease of the mesangium...
November 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/29020489/multiple-evanescent-white-dot-syndrome-following-acute-epstein-barr-virus-infection
#12
Chang-Sue Yang, Ming-Hung Hsieh, Huan-I Su, Yih-Shiuan Kuo
PURPOSE: To investigate the association between multiple evanescent white dot syndrome (MEWDS) and Epstein-Barr (EB) virus infection. METHODS: A prospective, consecutive case series study was performed in patients with the characteristic findings of MEWDS. Patients received EB viral-specific antibody serologic tests. RESULTS: Five cases of MEWDS who had prodromal flu-like symptoms were enrolled, comprising 2 women and 3 men with a mean age of 34...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28933179/-infectious-complications-related-to-liver-transplants
#13
Vladimír Mejzlík, Libuše Husová, Milan Kuman, Soňa Štěpánková, Jiří Ondrášek, Petr Němec
Infection is a feared complication in the process of transplantation. The study discusses sources of infection, screening of infection and risk factors for infection, time occurrence of individual infections during the peritransplantation and posttransplantation course. It describes the most frequent forms of bacterial, viral and mycotic infections. It specifies efficient prophylactic measures that considerably reduce the risk of infection following liver transplantation.Key words: bacterial infection - cytomegalovirus (CMV) - EB virus (EBV) - hepatitis B (HBV) - hepatitis C (HCV) - liver transplantation - mycotic infection prophylaxis - risk factors - viral infection...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28862190/seroprevalence-of-cytomegalovirus-in-donors-opportunistic-viral-infections-in-liver-transplant-recipients
#14
Joy Varghese, S Subramanian, Mettu Srinivas Reddy, Naresh Shanmugam, G Balajee, Vijaya Srinivasan, Jayanthi Venkataraman, Rela Mohamed
BACKGROUND & OBJECTIVES: Opportunistic virus infections are common in liver transplant (LT) recipients. There is a risk of developing infection with cytomegalovirus (CMV) and herpes-related viruses such as herpes simplex virus-1 and 2 (HSV-1 & 2), Epstein-Barr virus (EBV) and Varicella Zoster virus (VZV), reactivation of infection and recurrent infection. This study was conducted to determine CMV seropositivity in donors and its influence on LT recipients and seropositivity of CMV, HSV-1 and 2, EB viral capsid antigen (EBVCA) and VZV in LT recipients and their reactivation...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28702343/eb-virus-reactivation-triggers-thrombotic-thrombocytopenic-purpura-in-a-healthy-adult
#15
Satoko Oka, Masaharu Nohgawa
Thrombotic thrombocytopenic purpura (TTP) is rare but life-threatening disease, characterized typically by microangiopathic hemolytic anemia (MAHA), profound peripheral thrombocytopenia and severe deficiency in the von Willebrand factor-cleaving prortease ADAMTS13. It has been reported that acquired immune TTP is closely associated with human immunodeficiency virus infection and influenza infection or vaccination. However, it has not been reported to be associated with Epstein Barr Virus infection or reactivation...
2017: Leukemia Research Reports
https://www.readbyqxmd.com/read/28688268/tfeb-mediated-activation-of-the-lysosome-autophagy-system-affects-the-transduction-efficiency-of-adeno-associated-virus-2
#16
Lauren Popp, Eric Gomez, Whitney Orji, Michelle Ho, Junghae Suh, Laura Segatori
Adeno-associated virus (AAV)-mediated gene transfer is an appealing therapeutic option due to AAV's safety profile. Effective delivery of AAV's genetic cargo to the nucleus, however, requires evasion of host cell barriers, including cellular clearance mechanisms mediated by the lysosome-autophagy system. We used AAV serotype 2 to monitor the autophagic response to cellular internalization of AAV and to characterize the effect of AAV-induced activation of autophagy on transgene expression. We found AAV2 internalization to induce activation of transcription factor EB, a master regulator of autophagy and lysosomal biogenesis, and upregulation of the lysosome-autophagy system...
October 2017: Virology
https://www.readbyqxmd.com/read/28671695/engineered-aavs-for-efficient-noninvasive-gene-delivery-to-the-central-and-peripheral-nervous-systems
#17
Ken Y Chan, Min J Jang, Bryan B Yoo, Alon Greenbaum, Namita Ravi, Wei-Li Wu, Luis Sánchez-Guardado, Carlos Lois, Sarkis K Mazmanian, Benjamin E Deverman, Viviana Gradinaru
Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer. Nevertheless, AAVs that provide efficient transduction across specific organs or cell populations are needed. Here, we describe AAV-PHP.eB and AAV-PHP.S, capsids that efficiently transduce the central and peripheral nervous systems, respectively. In the adult mouse, intravenous administration of 1 × 1011 vector genomes (vg) of AAV-PHP.eB transduced 69% of cortical and 55% of striatal neurons, while 1 × 1012 vg of AAV-PHP.S transduced 82% of dorsal root ganglion neurons, as well as cardiac and enteric neurons...
August 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28638688/spontaneous-regression-of-epstein-barr-virus-associated-lymphoproliferative-disorder-in-a-juvenile-idiopathic-arthritis-patient-after-the-discontinuation-of-methotrexate-and-etanercept
#18
Ariane Klein, Harald Reinhard, Annette M Mueller, Gerd Horneff
A case of a 16-year-old female with polyarticular juvenile idiopathic arthritis (JIA) since the age of 4 years is reported here. This patient also suffered from multiple congenital anomalies. On long-term treatment with oral methotrexate (MTX) and etanercept, multiple subcutaneous nodules were detected, which were accompanied by increased lactate dehydrogenase and uric acid levels. A biopsy of the largest nodule revealed Epstein-Barr (EB) virus-positive diffuse large B-cell lymphoma (DLBCL). The patient was classified as clinical stage IIIA due to a mediastinal lesion...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28468603/fluorescence-in-situ-hybridization-is-superior-for-monitoring-epstein-barr-viral-load-in-infectious-mononucleosis-patients
#19
Pengfei Cao, Meili Zhang, Wei Wang, Yafei Dai, Buqing Sai, Jun Sun, Lujuan Wang, Fan Wang, Guiyuan Li, Juanjuan Xiang
BACKGROUND: Epstein Barr virus (EBV) plays a causal role in some diseases, including infectious mononucleosis, lymphoproliferative diseases and nasopharyngeal carcinoma. Detection of EBV infection has been shown to be a useful tool for diagnosing EBV-related diseases. In the present study, we compared the performance of molecular tests, including fluorescence in situ hybridization (FISH) and EBV real-time PCR, to those of serological assays for the detection of EBV infection. METHODS: Thirty-eight patients with infectious mononucleosis (IM) were enrolled, of whom 31 were diagnosed with a mild type, and seven were diagnosed with IM with haemophagocytic lymphohistiocytosis and chronic active EBV infection...
May 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28446293/-clinical-significance-of-peripheral-blood-eb-virus-detection-in-nk-t-cell-lymphoma-patients
#20
Jing Zhang, Lei Yue, Ying-Lu Li
OBJECTIVE: To explore the clinical significance of peripheral blood EB virus detection in NK/T cell lymphoma patients. METHODS: The positive rate of EB virus and EBV-DNA in 85 cases of NK/T cell lymphoma was assayed; the correlation of positive rate of EB virus with clinical staging, short-term and long-term prognosis was analyzed. RESULTS: The positive rate of EB virus in NK/T cell lymphoma was high (80.00%). The EBV-DNA copy number in peripheral blood leukocytes was higher than that in peripheral plasma (P<0...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
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