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HCC and p21

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https://www.readbyqxmd.com/read/27894814/tanshinone-iia-induced-cell-death-via-mir30b-p53-ptpn11-shp2-signaling-pathway-in-human-hepatocellular-carcinoma-cells
#1
Xuanqi Ren, Cui Wang, Binbin Xie, Linfeng Hu, Hui Chai, Lei Ding, Lihua Tang, Yongliang Xia, Xiaobing Dou
Tanshinone IIA, a multi-pharmaceutical compound from traditional Chinese herb, has been reported to have anti-hepatocarcinomic (HCC) properties through cell death induction. Apart from the typical p53-dependent pathway, mechanisms of the anti-carcinogenic role of Tanshinone remain scarce. In an effort to explore the mechanism behind Tanshinone IIA, we detected the upstream of the p53 and the potential novel pathway. Tanshinone IIA dose-dependently initiated HepG2 cell apoptosis and cell cycle arrest at the G1 checkpoint...
November 25, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27835881/il-37-suppresses-hepatocellular-carcinoma-growth-by-converting-psmad3-signaling-from-jnk-psmad3l-c-myc-oncogenic-signaling-to-psmad3c-p21-tumor-suppressive-signaling
#2
Rui Liu, Chengyong Tang, Ai Shen, Huating Luo, Xufu Wei, Daofeng Zheng, Chao Sun, Zhongtang Li, Di Zhu, Tingting Li, Zhongjun Wu
IL-37 has been characterized as a fundamental inhibitor of innate immunity and a tumor suppressor in several cancers. However, the molecular mechanism of IL-37 in hepatocellular carcinoma (HCC) is largely unclear. In this study we found IL-37 expression was down-regulated in human HCC tissues and cell lines, and was negatively correlated with tumor size, vascular invasion, as well as overall-survial and disease-free survival (OS and DFS) of HCC. Multivariate Cox analysis revealed that IL-37 was an independent prognostic indicator for OS and DFS in HCC...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27832471/expression-pattern-of-bccip-in-hepatocellular-carcinoma-is-correlated-with-poor-prognosis-and-enhanced-cell-proliferation
#3
Zhipeng Lin, Baoying Hu, Wenkai Ni, Xiaofei Mao, Huiling Zhou, Jiale Lv, Bihui Yin, Zhongyi Shen, Miaomiao Wu, Wensen Ding, Mingbing Xiao, Runzhou Ni
BCCIP was originally identified as a BRCA2- and CDKN1A- (Cip1/waf1/p21) interacting protein, also known as BCCIP. It has been reported to express in various types of cancers, including colorectal cancer (CRC), astrocytic brain tumors, and glioblastomas. However, the relationship between BCCIP expression and clinicopathological features of hepatocellular carcinoma (HCC) remains to be determined. Herein, we demonstrated that BCCIP was downregulated in clinical HCC tissues; its level was inversely correlated with multiple clinicopathological factors, such as tumor grade, tumor size, and Ki67 expression...
November 10, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27824900/sirt6-depletion-suppresses-tumor-growth-by-promoting-cellular-senescence-induced-by-dna-damage-in-hcc
#4
Namgyu Lee, Hye Guk Ryu, Jung-Hee Kwon, Dae-Kyum Kim, Sae Rom Kim, Hee Jung Wang, Kyong-Tai Kim, Kwan Yong Choi
The role of Sirtuin 6 (SIRT6) as a tumor suppressor or oncogene in liver cancer remains controversial. Thus, we identified the specific role of SIRT6 in the progression of hepatocellular carcinoma (HCC). SIRT6 expression was significantly higher in HCC cell lines and HCC tissues from 138 patients than in an immortalized hepatocyte cell line, THLE-2 and non-tumor tissues, respectively. SIRT6 knockdown by shRNA suppressed the growth of HCC cells and inhibited HCC tumor growth in vivo. In addition, SIRT6 silencing significantly prevented the growth of HCC cell lines by inducing cellular senescence in the p16/Rb- and p53/p21-pathway independent manners...
2016: PloS One
https://www.readbyqxmd.com/read/27803767/lycopene-modulates-cellular-proliferation-glycolysis-and-hepatic-ultrastructure-during-hepatocellular-carcinoma
#5
Prachi Gupta, Nisha Bhatia, Mohinder Pal Bansal, Ashwani Koul
AIM: To investigate the effect of lycopene extracted from tomatoes (LycT) on ultrastructure, glycolytic enzymes, cell proliferation markers and hypoxia during N-Nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. METHODS: Female BALB/c mice were randomly divided into four groups: The Control, NDEA (200 mg NDEA/kg b.w. given i.p.), LycT (5 mg/kg b.w. given orally on alternate days) and LycT + NDEA group. The mRNA and protein expression of various cell proliferation markers (PCNA, Cyclin D1, and p21) were assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay, respectively...
October 18, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27779207/hbv-core-promoter-mutations-and-akt-upregulate-s-phase-kinase-associated-protein-2-to-promote-postoperative-hepatocellular-carcinoma-progression
#6
Lubiao Chen, Lin Gu, Yurong Gu, Hongbo Wang, Meihai Deng, Zania Stamataki, Ye Htun Oo, Yuehua Huang
Mutations in the hepatitis B virus (HBV) core promoter (CP) have been shown to be associated with hepatocellular carcinoma (HCC). The CP region overlaps HBV X gene, which activates AKT to regulate hepatocyte survival. However, the cooperation between these two cascades in HCC progression remains poorly understood. Here, we assayed virological factors and AKT expression in liver tissues from 56 HCC patients with better prognoses (BHCC, ≥5-year survival) and 58 with poor prognoses (PHCC, <5-year survival) after partial liver resection...
October 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27737960/swi-snf-regulates-a-transcriptional-program-that-induces-senescence-to-prevent-liver-cancer
#7
Luca Tordella, Sadaf Khan, Anja Hohmeyer, Ana Banito, Sabrina Klotz, Selina Raguz, Nadine Martin, Gopuraja Dhamarlingam, Thomas Carroll, José Mario González Meljem, Sumit Deswal, Juan Pedro Martínez-Barbera, Ramón García-Escudero, Johannes Zuber, Lars Zender, Jesús Gil
Oncogene-induced senescence (OIS) is a potent tumor suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC). Here, we describe how knockdown of the SWI/SNF component ARID1B prevents OIS and cooperates with RAS to induce liver tumors. ARID1B controls p16(INK4a) and p21(CIP1a) transcription but also regulates DNA damage, oxidative stress, and p53 induction, suggesting that SWI/SNF uses additional mechanisms to regulate senescence...
October 1, 2016: Genes & Development
https://www.readbyqxmd.com/read/27698442/up-regulation-of-mir-95-3p-in-hepatocellular-carcinoma-promotes-tumorigenesis-by-targeting-p21-expression
#8
Jian Ye, Yufeng Yao, Qixue Song, Sisi Li, Zhenkun Hu, Yubing Yu, Changqing Hu, Xingwen Da, Hui Li, Qiuyun Chen, Qing K Wang
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers. To elucidate new regulatory mechanisms for heptocarcinogenesis, we investigated the regulation of p21, a cyclin-dependent kinase (CDK) inhibitor encoded by CDKN1A, in HCC. The expression level of p21 is decreased with the progression of HCC. Luciferase assays with a luciferase-p21-3' UTR reporter and its serial deletions identified a 15-bp repressor element at the 3'-UTR of CDKN1A, which contains a binding site for miR-95-3p. Mutation of the binding site eliminated the regulatory effect of miR-95-3p on p21 expression...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27671301/polo-like-kinase-1-targeting-chitosan-nanoparticles-suppress-the-progression-of-hepatocellular-carcinoma
#9
Dongzhi Wang, Renan Chang, Gang Wang, Baoying Hu, Yong Qiang, Zhong Chen
BACKGROUND: Recent investigations have implicated that Chitosan-nucleotide nanoparticles might be useful non-viral carriers in gene therapy. Polo-like kinase 1 (PLK1) has been reported to be an important oncogene that exerted considerable therapeutic value in hepatocellular carcinoma (HCC). OBJECTIVE: We explored whether Galactosylated chitosan-graft-poly(ethylene glycol) (GCP) nanoparticle-mediated delivery of PLK1 siRNA nucleotides could serve as an effective anti-cancer agent for HCC therapy...
September 26, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27650540/bone-morphogenetic-protein-9-is-a-potent-growth-inhibitor-of-hepatocellular-carcinoma-and-reduces-the-liver-cancer-stem-cells-population
#10
Jae Woo Jung, So-Mi Yoon, Subin Kim, Yun-Hui Jeon, Byung-Hak Yoon, Su-Geun Yang, Min Kyoung Kim, Senyon Choe, Mario Meng-Chiang Kuo
The biological role of BMP-9 signaling in liver cancer remains dubious. To explore the potential use of BMP-9 signaling for anti-cancer therapy, we used recombinant human BMP-9, which we referred to as MB109, to study the effect on growth of fifteen hepatocellular carcinoma (HCC) cell lines. MB109 effectively inhibits the proliferation of nine HCC cells in vitro. The anti-proliferative effect was found to be induced by turning on p21 signaling, which caused survivin suppression and G0/G1 cell cycle arrest. ID3 was identified to be the mediator of the MB109-induced p21 expression...
September 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27633001/prolonged-survival-in-hepatocarcinoma-patients-with-increased-regucalcin-gene-expression-hepg2-cell-proliferation-is-suppressed-by-overexpression-of-regucalcin-in-vitro
#11
Masayoshi Yamaguchi, Satoru Osuka, M Neale Weitzmann, Bassel F El-Rayes, Mamoru Shoji, Tomiyasu Murata
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide and ranks third in overall global cancer-related mortality rates. Importantly, in this study gene expression data demonstrate that prolonged survival in HCC patients is associated with increased regucalcin gene expression. Regucalcin has been shown to play a pivotal role as a transcription repressor and diminished expression or activity of regucalcin may play a key role in the development of human carcinogenesis. Indeed, overexpression of regucalcin suppressed the proliferation, cell death, and migration of human HCC HepG2 cells in vitro...
October 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27588483/activation-of-akt-pathway-by-nrf2-pdgfa-feedback-loop-contributes-to-hcc-progression
#12
Danyang Liu, Yonglong Zhang, Yingze Wei, Guoyuan Liu, Yufeng Liu, Qiongmei Gao, Liping Zou, Wenjiao Zeng, Nong Zhang
Nuclear factor erythroid-2-related factor 2 (Nrf2), a master transcription factor in the antioxidant response, has been found to be ubiquitously expressed in various cancer cells and in the regulation tumor proliferation, invasion, and chemoresistance activities. The regulatory roles of Nrf2 in controlling Hepatocellular carcinoma (HCC) progression remain unclear. In this study, we demonstrated that Nrf2 was significantly elevated in HCC cells and tissues and was correlated with poor prognosis of HCCs. Consistently, Nrf2 significantly promoted HCC cell growth both in vitro and in vivo...
August 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27542674/mir-384-regulated-irs1-expression-and-suppressed-cell-proliferation-of-human-hepatocellular-carcinoma
#13
Yue-Yuan Lai, Fei Shen, Wen-Song Cai, Ji-Wei Chen, Jian-Hua Feng, Jie Cao, Huan-Qing Xiao, Guang-Hui Zhu, Bo Xu
Acquired evidence indicated that microRNAs (miRNAs) played essential roles in cancer development, including hepatocellular carcinoma (HCC). Functions and mechanisms of miRNAs involved in HCC remain largely unknown. Here, we found that miR-384 was significantly downregulated in HCC cells and tissues by RT-PCR. Gain and loss of function studies revealed that miR-384 significantly suppressed HCC cell proliferation. Insulin receptor substrate 1(IRS1) was identified as a direct and functional target of miR-384. Moreover, miR-384 decreased IRS1 expression, subsequently downregulating cyclin D1 and upregulating p21 and p-Rb expression...
August 19, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27525972/a-hybrid-chalcone-combining-the-trimethoxyphenyl-and-isatinyl-groups-targets-multiple-oncogenic-proteins-and-pathways-in-hepatocellular-carcinoma-cells
#14
Lili Cao, Lijun Zhang, Xiang Zhao, Ye Zhang
Small molecule inhibitors that can simultaneously inhibit multiple oncogenic proteins in essential pathways are promising therapeutic chemicals for hepatocellular carcinoma (HCC). To combine the anticancer effects of combretastatins, chalcones and isatins, we synthesized a novel hybrid molecule 3',4',5'-trimethoxy-5-chloro-isatinylchalcone (3MCIC). 3MCIC inhibited proliferation of cultured HepG2 cells, causing rounding-up of the cells and massive vacuole accumulation in the cytoplasm. Paxillin and focal adhesion plaques were downregulated by 3MCIC...
2016: PloS One
https://www.readbyqxmd.com/read/27502069/egfr-and-syne2-are-associated-with-p21-expression-and-syne2-variants-predict-post-operative-clinical-outcomes-in-hbv-related-hepatocellular-carcinoma
#15
Chuangye Han, Xiwen Liao, Wei Qin, Long Yu, Xiaoguang Liu, Gang Chen, Zhengtao Liu, Sicong Lu, Zhiwei Chen, Hao Su, Guangzhi Zhu, Zili Lu, Zhiming Liu, Xue Qin, Ying Gui, Zengnan Mo, Lequn Li, Tao Peng
This study was to explore the association between gene variants and p21 expression and investigate the TP53-independent p21 regulation in hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) patients from Guangxi by genome-wide association study. 426 HBV-related HCC patients were enrolled. Results showed that, after quality control, a total of 21,643 SNPs were identified in 107 p21 positive and 298 p21 negative patients. The variants of epidermal growth factor receptor (EGFR; rs2227983 and rs6950826) and spectrin repeat containing, nuclear envelope 2 (SYNE2; rs8010699, rs4027405 and rs1890908) were associated with p21 expression...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27496652/lincrna-p21-impacts-prognosis-in-resected-non-small-cell-lung-cancer-patients-through-angiogenesis-regulation
#16
Joan J Castellano, Alfons Navarro, Nuria Viñolas, Ramon M Marrades, Jorge Moises, Anna Cordeiro, Adela Saco, Carmen Muñoz, Dolors Fuster, Laureano Molins, Josep Ramirez, Mariano Monzo
INTRODUCTION: Long intergenic noncoding RNA-p21 (lincRNA-p21) is a long noncoding RNA transcriptionally activated by tumor protein p53 (TP53) and hypoxia inducible factor 1 alpha subunit (HIF1A). It is involved in the regulation of TP53-dependent apoptosis and the Warburg effect. We have investigated the role of lincRNA-p21 in NSCLC. METHODS: LincRNA-p21 expression was assessed in tumor and normal tissue from 128 patients with NSCLC and correlated with time to relapse and cancer-specific survival (CSS)...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27486509/histone-acetyl-transferase-gcn5-promotes-human-hepatocellular-carcinoma-progression-by-enhancing-aib1-expression
#17
Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li, Chundong Yu
BACKGROUND: General control non-depressible 5 (GCN5) is a crucial catalytic component of a transcriptional regulatory complex that plays important roles in cellular functions from cell cycle regulation to DNA damage repair. Although GCN5 has recently been implicated in certain oncogenic roles, its role in liver cancer progression remains vague. RESULTS: In this study, we report that GCN5 was overexpressed in 17 (54.8 %) of 31 human hepatocellular carcinoma (HCC) specimens...
2016: Cell & Bioscience
https://www.readbyqxmd.com/read/27421660/adenovirus-mediated-co-expression-of-ing4-and-pten-cooperatively-enhances-their-antitumor-activity-in-human-hepatocellular-carcinoma-cells
#18
Nargis Rakshit, Sijun Yang, Wei Zhou, Yi Xu, Chenghui Deng, Jiecheng Yang, Huijun Yu, Wenxiang Wei
Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are well known as tumor suppressors that are closely related to tumor occurrence and progression. It was reported that ING4 and PTEN showed synergistic antitumor activities in nasopharyngeal carcinoma cells. The two tumor suppressors demonstrated synergistic effect on growth inhibition and apoptosis activation. In this study, we investigated their therapeutic potential in hepatocellular carcinoma (HCC) cells...
August 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27391793/lincrna-p21-inhibits-invasion-and-metastasis-of-hepatocellular-carcinoma-through-notch-signaling-induced-epithelial-mesenchymal-transition
#19
Meng Jia, Li Jiang, Ya-Dong Wang, Jin-Zhao Huang, Miao Yu, Huan-Zhou Xue
AIM: Emerging evidence has showed that long non-coding RNA (lncRNA) play an important role in the occurrence and development of various cancers. In the present study, the expression level of lincRNA-p21 was investigated in hepatocellular carcinoma (HCC), and its role in invasion of HCC was also explored. METHODS: The lincRNA-p21 levels in human HCC tumor tissue and cell lines HepG2 and SMMC-7721 were determined by real-time polymerase chain reaction. Transfected HCC cells with pcDNA-lincRNA-p21 or si-lincRNA-p21 for overexpression or downregulation of lincRNA-p21, the Notch signaling and epithelial-mesenchymal transition (EMT)-related proteins and cell invasion were measured by western blot and Transwell assay, respectively...
February 1, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27177208/a-novel-all-trans-retinoic-acid-derivative-4-amino%C3%A2-2%C3%A2-trifluoromethyl-phenyl-retinate-inhibits-the-proliferation-of-human-hepatocellular-carcinoma-hepg2-cells-by-inducing-g0-g1-cell-cycle-arrest-and-apoptosis-via-upregulation-of-p53-and-aspp1-and-downregulation
#20
Hui Liu, Feihu Chen, Ling Zhang, Qing Zhou, Shuyu Gui, Yuan Wang
4-Amino-2-trifluoromethyl-phenyl retinate (ATPR), a novel all-trans retinoic acid (ATRA) derivative, was reported to function as a tumor inhibitor in various types of cancer cells in vitro. However, little is known concerning its antitumor effect on human hepatocellular carcinoma (HCC) HepG2 cells. The aims of the present study were to investigate the effects of ATPR on the proliferation of HepG2 cells and to explore the probable mechanisms. A series of experiments were performed following the treatment of HepG2 cells with ATRA and ATPR...
July 2016: Oncology Reports
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