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https://www.readbyqxmd.com/read/29046034/-neurological-manifestations-in-atypical-kawasaki-disease
#1
Edgar Martínez-Guzmán, Luisa Berenise Gámez-González, Francisco Rivas-Larrauri, Giovanni Sorcia-Ramírez, Marco Yamazaki-Nakashimada
BACKGROUND: Kawasaki disease (KD) is a type of systemic vasculitis of unknown etiology. Atypical Kawasaki disease is defined as that where there are signs and symptoms not corresponding to the classical criteria for this nosological entity. Children with atypical Kawasaki disease may present with acute abdominal symptoms, meningeal irritation, pneumonia or renal failure. CLINICAL CASES: We describe 4 children with ages ranging from 2 to 12 years who had atypical Kawasaki disease, with neurological and gastrointestinal symptoms as part of the systemic presentation of the disease...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29046011/-biomarkers-in-diagnosis-treatment-and-prognosis-of-infectious-lung-diseases
#2
M Unnewehr, M Kolditz, W Windisch, B Schaaf
Biomarkers play an important role in the management of infectious pulmonary diseases, even though there is only limited evidence that biomarker-guided therapies are superior to clinical strategies.Well-established indications for the use of biomarkers are the guidance of the duration of antibiotic therapy in community-acquired pneumonia (CAP) by PCT, the decision against the use of antibiotics by CRP or PCT in ambulatory settings, and the evaluation of CAP treatment by CRP or PCT kinetics.In the prognostic assessment of CAP, the standard biomarkers of acute organ dysfunction should be given priority, e...
October 18, 2017: Pneumologie
https://www.readbyqxmd.com/read/29045693/pharmacokinetics-of-ceftaroline-in-a-preterm-infant-with-methicillin-resistant-staphylococcus-aureus-pneumonia
#3
Sara N Salerno, Janice Bernhardt, Matthew Laughon, Ravi Jhaveri, Matthew Massaro, Daniel Gonzalez
We report here the first pharmacokinetic-pharmacodynamic relationship for ceftaroline in a preterm infant born at <28 weeks' gestational age who was given ceftaroline (8.5 mg/kg every 8 hours) for pneumonia attributable to methicillin-resistant Staphyloccocus aureus. This dose of ceftaroline was adequate to achieve the pharmacodynamic endpoint associated with efficacy for methicillin-resistant Staphyloccocus aureus.
October 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29044898/use-of-computed-tomography-and-minimum-intensity-projection-in-the-detection-of-lobar-pneumonia-mimicking-lung-lobe-torsion-in-a-dog
#4
Sang-Kwon Lee, Kyoung-Oh Cho, Mia Madel Alfajaro, Juhwan Lee, Dohyeon Yu, Jihye Choi
A 10-year-old female spayed Dachshund was referred with progressive coughing for 1 month. The dog was tentatively diagnosed with right middle lung torsion based on pleural effusion, vesicular emphysema, abruptly ending bronchus in consolidated right middle lung, and no contrast enhancement of the affected lobe on radiography and computed tomography (CT). There was no evidence of torsion upon thoracotomy, and histological examination confirmed lobar pneumonia. The CT images were reevaluated using minimum intensity projection and revealed normal bronchial courses...
October 16, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29044893/tsynthetic-klebsiella-pneumoniae-shewanella-oneidensis-consortium-enables-glyc-erol-fed-high-performance-microbial-fuel-cells
#5
Feng Li, Changji Yin, Liming Sun, Yuanxiu Li, Xuewu Guo, Hao Song
Microbial fuel cell (MFC) is an eco-friendly bio-electrochemical system that uses mi-croorganism as biocatalyst to convert biomass into electricity. Glycerol, as a waste in the biodiesel refinery processes, is an appealing substrate for MFC. Nevertheless, glycerol cannot be utilized as carbon source by well-known exoelectrogens such as Shewanella oneidensis. Herein, to generate electricity by rapidly harnessing glycerol, we rationally constructed a Klebsiella pneumoniae-Shewanella oneidensis microbial consortium to efficiently harvest electricity from glycerol, in which K...
October 18, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29044226/bone-marrow-transplant-induced-alterations-in-notch-signaling-promote-pathologic-th17-responses-to-%C3%AE-herpesvirus-infection
#6
S J Gurczynski, X Zhou, M Flaherty, C A Wilke, B B Moore
Idiopathic pneumonia syndrome (IPS) is a common, often fatal, complication following hematopoietic stem cell transplantation (HSCT) characterized by severe pneumonitis and interstitial fibrosis. Fully reconstituted syngeneic bone marrow transplant (BMT) mice infected with murine γ-herpesvirus-68 develop interleukin-17 (IL-17)-driven pneumonitis and fibrosis, which mimics clinical manifestations of IPS. We found CD103+ and CD11b+ dendritic cells (DCs) are selectively deficient for the Notch ligand, DLL4, following BMT and CD4+ T cells isolated from lungs and spleens of infected BMT mice display Notch signaling defects...
October 18, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/29043803/identification-of-privileged-antichlamydial-natural-products-by-a-ligand-based-strategy
#7
Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero
The obligate intracellular pathogen Chlamydia pneumoniae remains a difficult target for antimicrobial therapy. Owing to the permeability barrier placed by bacterial and host vacuolar membranes, as well as the propensity of the bacterium for persistent infections, treatment failures are common. Despite the urgent need for new antichlamydial compounds, their discovery is challenged by the technically demanding assay procedures and lack of validated targets. An alternative strategy of using naturally occurring compounds and their derivatives against C...
October 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29043687/-pleural-cavity-concerns
#8
I Simal, M A García-Casillas, J Cerdà, L Pérez, B Fernández, M De la Torre, M Fanjul, E Molina, J C De Agustín
INTRODUCTION: Persistent air leak (PAL) is a common problem. We asses our experience in the management of these patients. MATERIAL AND METHODS: Retrospective review of patients with chest tubes after bronchopulmonary pneumothorax (due to lung resections, spontaneous pneumothorax, necrotizing pneumonia) from 2010 to 2015. We studied clinical data, PAL incidence, risk factors and treatment, considering PAL ≥ 5 days. RESULTS: Thirty-seven cases (28 patients) between 0-16years: 26 lung resections, 11 pneumothorax...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29043424/imaging-community-acquired-pneumonia-in-children
#9
EDITORIAL
Savvas Andronikou
No abstract text is available yet for this article.
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29043423/preliminary-report-from-the-world-health-organisation-chest-radiography-in-epidemiological-studies-project
#10
REVIEW
Nasreen Mahomed, Nicholas Fancourt, John de Campo, Margaret de Campo, Aliu Akano, Thomas Cherian, Olivia G Cohen, David Greenberg, Stephen Lacey, Neera Kohli, Henrique M Lederman, Shabir A Madhi, Veronica Manduku, Eric D McCollum, Kate Park, Jose Luis Ribo-Aristizabal, Naor Bar-Zeev, Katherine L O'Brien, Kim Mulholland
Childhood pneumonia is among the leading infectious causes of mortality in children younger than 5 years of age globally. Streptococcus pneumoniae (pneumococcus) is the leading infectious cause of childhood bacterial pneumonia. The diagnosis of childhood pneumonia remains a critical epidemiological task for monitoring vaccine and treatment program effectiveness. The chest radiograph remains the most readily available and common imaging modality to assess childhood pneumonia. In 1997, the World Health Organization Radiology Working Group was established to provide a consensus method for the standardized definition for the interpretation of pediatric frontal chest radiographs, for use in bacterial vaccine efficacy trials in children...
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29043422/guidelines-for-the-use-of-chest-radiographs-in-community-acquired-pneumonia-in-children-and-adolescents
#11
REVIEW
Savvas Andronikou, Elena Lambert, Jarred Halton, Lucy Hilder, Iona Crumley, Mark D Lyttle, Cara Kosack
National guidance from the United Kingdom and the United States on community-acquired pneumonia in children states that chest radiographs are not recommended routinely in uncomplicated cases. The main reason in the ambulatory setting is that there is no evidence of a substantial impact on clinical outcomes. However clinical practice and adherence to guidance is multifactorial and includes the clinical context (developed vs. developing world), the confidence of the attending physician, the changing incidence of complications (according to the success of immunisation programs), the availability of alternative imaging (and its relationship to perceived risks of radiation) and the reliability of the interpretation of imaging...
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29043420/lung-ultrasound-for-the-diagnosis-of-community-acquired-pneumonia-in-children
#12
REVIEW
Jacob A M Stadler, Savvas Andronikou, Heather J Zar
Ultrasound (US) has been proposed as an alternative first-line imaging modality to diagnose community-acquired pneumonia in children. Lung US has the potential benefits over chest radiography of being radiation free, subject to fewer regulatory requirements, relatively lower cost and with immediate bedside availability of results. However, the uptake of lung US into clinical practice has been slow and it is not yet included in clinical guidelines for community-acquired pneumonia in children. The aim of this review is to give an overview of the equipment and techniques used to perform lung US in children with suspected pneumonia and the interpretation of relevant sonographic findings...
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29043419/computed-tomography-in-children-with-community-acquired-pneumonia
#13
REVIEW
Savvas Andronikou, Pierre Goussard, Erich Sorantin
Diagnostic imaging plays a significant role in both the diagnosis and treatment of complications of pneumonia in children and chest radiography is the imaging modality of choice. Computed tomography (CT) on the other hand, is not currently a first-line imaging tool for children with suspected uncomplicated community-acquired pneumonia and is largely reserved for when complications of pneumonia are suspected or there is difficulty in differentiating pneumonia from other pathology. This review outlines the situations where CT needs to be considered in children with pneumonia, describes the imaging features of the parenchymal and pleural complications of pneumonia, discusses how CT may have a wider role in developing countries where human immunodeficiency virus (HIV) and tuberculosis are prevalent, makes note of the role of CT scanning for identifying missed foreign body aspiration and, lastly, addresses radiation concerns...
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29043418/lung-magnetic-resonance-imaging-for-pneumonia-in-children
#14
REVIEW
Mark C Liszewski, Süreyya Görkem, Kushaljit S Sodhi, Edward Y Lee
Technical factors have historically limited the role of MRI in the evaluation of pneumonia in children in routine clinical practice. As imaging technology has advanced, recent studies utilizing practical MR imaging protocols have shown MRI to be an accurate potential alternative to CT for the evaluation of pneumonia and its complications. This article provides up-to-date MR imaging techniques that can be implemented in most radiology departments to evaluate pneumonia in children. Imaging findings in pneumonia on MRI are also reviewed...
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29043417/community-acquired-pneumonia-in-children-a-changing-spectrum-of-disease
#15
REVIEW
David M le Roux, Heather J Zar
Pneumonia remains the leading cause of death in children outside the neonatal period, despite advances in prevention and management. Over the last 20 years, there has been a substantial decrease in the incidence of childhood pneumonia and pneumonia-associated mortality. New conjugate vaccines against Haemophilus influenzae type b and Streptococcus pneumoniae have contributed to decreases in radiologic, clinical and complicated pneumonia cases and have reduced hospitalization and mortality. The importance of co-infections with multiple pathogens and the predominance of viral-associated disease are emerging...
October 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29043218/evaluation-of-antioxidant-and-antimicrobial-activities-of-ethanol-extracts-of-three-kinds-of-strawberries
#16
Semeneh Seleshe, Jong Seok Lee, Sarah Lee, Hye Jin Lee, Ga Ryun Kim, Joohong Yeo, Jong Yea Kim, Suk Nam Kang
The antioxidant and antimicrobial activities of three kinds of strawberry ethanol extracts from Robus corchorifolius L. f. (RCL), Rubus parvifolius L. var. parvifolius (RPL), and Duchesnea chrysantha Miq. (DCM) were investigated. The RPL was highest (P<0.05) in phenolic, flavonoid, and anthocyanin contents. 2,2-Diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activities of RPL and DCM extracts were higher than that of RCL (P<0.05). Hydrogen peroxide scavenging activity of RPL was high compared to DCM and RCL (P<0...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29043211/native-valve-endocarditis-caused-by-achromobacter-xylosoxidans-a-case-report-and-review-of-literature
#17
Caio Godoy Rodrigues, Jairo Rays, Marcia Yoshie Kanegae
Achromobacter xylosoxidans is a Gram-negative aerobic bacterium first described by Yabuuchi and Ohyama in 1971. A. xylosoxidans is frequently found in aquatic environments. Abdominal, urinary tract, ocular, pneumonia, meningitis, and osteomyelitis are the most common infections. Infective endocarditis is rare. As far as we know, until now, only 19 cases have been described, including this current report. We report the case of community-acquired native valve endocarditis caused by A. xylosoxidans in an elderly patient without a concomitant diagnosis of a malignancy or any known immunodeficiency...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29043150/community-acquired-pneumonia-in-the-united-kingdom-a-call-to-action
#18
EDITORIAL
James Chalmers, James Campling, Gillian Ellsbury, Peter M Hawkey, Harish Madhava, Mary Slack
Pneumococcal disease has a high burden in adults in the United Kingdom (UK); however, the total burden is underestimated, principally because most cases of community-acquired pneumonia (CAP) are non-invasive. Research into pneumonia receives poor funding relative to its disease burden (global mortality, disability-adjusted life years, and years lived with disability), ranking just 20 out of 25 for investment in infectious diseases in the UK. The current accuracy of data for establishing incidence rates is questionable, and it is a reflection of the paucity of research that much of the background information available derives from nearly 30 years ago...
2017: Pneumonia
https://www.readbyqxmd.com/read/29043069/recent-advances-in-the-understanding-and-management-of-klebsiella-pneumoniae
#19
REVIEW
David P Calfee
Klebsiella pneumoniae, a gram-negative bacillus of the Enterobacteriaceae family, is a component of the normal human microbiota and a common cause of community- and healthcare-associated infections. The increasing prevalence of antimicrobial resistance among K. pneumoniae isolates, particularly among those causing healthcare-associated infections, is an important public health concern. Infections caused by these multidrug-resistant organisms, for which safe and effective antimicrobial therapy options are extremely limited, are associated with poor outcomes for patients...
2017: F1000Research
https://www.readbyqxmd.com/read/29042865/additional-corticosteroids-or-alternative-antibiotics-for-the-treatment-of-macrolide-resistant-mycoplasma-pneumoniae-pneumonia
#20
EDITORIAL
Eun-Ae Yang, Kyung-Yil Lee
No abstract text is available yet for this article.
August 2017: Korean Journal of Pediatrics
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