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https://www.readbyqxmd.com/read/27072860/impaired-right-ventricular-pulmonary-arterial-coupling-and-effect-of-sildenafil-in-heart-failure-with-preserved-ejection-fraction-an-ancillary-analysis-from-the-phosphodiesterase-5-inhibition-to-improve-clinical-status-and-exercise-capacity-in-diastolic-heart
#1
MULTICENTER STUDY
Imad Hussain, Selma F Mohammed, Paul R Forfia, Gregory D Lewis, Barry A Borlaug, Dianne S Gallup, Margaret M Redfield
BACKGROUND: Right ventricular (RV) dysfunction (RVD) is a poor prognostic factor in heart failure with preserved ejection fraction (HFpEF). The physiological perturbations associated with RVD or RV function indexed to load (RV-pulmonary arterial [PA] coupling) in HFpEF have not been defined. HFpEF patients with marked impairment in RV-PA coupling may be uniquely sensitive to sildenafil. METHODS AND RESULTS: In a subset of HFpEF patients enrolled in the Phosphodiesteas-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) trial, physiological variables and therapeutic effect of sildenafil were examined relative to the severity of RVD (tricuspid annular plane systolic excursion [TAPSE]) and according to impairment in RV-PA coupling (TAPSE/pulmonary artery systolic pressure) ratio...
April 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/26904289/phenotypic-and-functional-changes-of-endothelial-and-smooth-muscle-cells-in-thoracic-aortic-aneurysms
#2
Anna Malashicheva, Daria Kostina, Aleksandra Kostina, Olga Irtyuga, Irina Voronkina, Larisa Smagina, Elena Ignatieva, Natalia Gavriliuk, Vladimir Uspensky, Olga Moiseeva, Jarle Vaage, Anna Kostareva
Thoracic aortic aneurysm develops as a result of complex series of events that alter the cellular structure and the composition of the extracellular matrix of the aortic wall. The purpose of the present work was to study the cellular functions of endothelial and smooth muscle cells from the patients with aneurysms of the thoracic aorta. We studied endothelial and smooth muscle cells from aneurysms in patients with bicuspid aortic valve and with tricuspid aortic valve. The expression of key markers of endothelial (CD31, vWF, and VE-cadherin) and smooth muscle (SMA, SM22α, calponin, and vimentin) cells as well extracellular matrix and MMP activity was studied as well as and apoptosis and cell proliferation...
2016: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/26117295/speckle-tracking-echocardiographic-measures-of-right-ventricular-function-correlate-with-improvement-in-exercise-function-after-percutaneous-pulmonary-valve-implantation
#3
MULTICENTER STUDY
Shahryar M Chowdhury, Ziyad M Hijazi, John T Fahey, John F Rhodes, Saibal Kar, Raj Makkar, Michael Mullen, Qi-Ling Cao, Girish S Shirali
BACKGROUND: Speckle-tracking echocardiographic (STE) measures of right ventricular (RV) function appear to improve after transcatheter pulmonary valve implantation (TPVI). Measures of exercise function, such as ventilatory efficiency (the minute ventilation [VE]/carbon dioxide production [VCO2] slope), have been shown to be prognostic of mortality in patients who may require TPVI. The aim of this study was to evaluate the correlation between STE measures of RV function and changes in VE/VCO2 after TPVI...
September 2015: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/25903740/quantitative-tissue-velocity-imaging-evaluation-of-ventricular-function-in-obstructive-sleep-apnoea-hypopnoea-syndrome-in-children
#4
Hong Mu, Junjie Liu, Kebo Gong, Dongmei Li, Jianji Zhang
This study aimed to evaluate the changes in left and right ventricular functions of children with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and to determine the efficacy of surgical treatment for OSAHS in children. The subjects included 20 normal controls and 55 children of OSAHS with adenoid and/or tonsil hypertrophy diagnosed by polysomnography (PSG). We divided the children with OSAHS into the mild group, moderate group and severe group of OSAHS according to the condition of apnoea-hypopnoea index (AHI) and the lowest of oxygen saturation (LSaO₂)...
June 2015: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/25736309/bnp-and-haematological-parameters-are-markers-of-severity-of-ebstein-s-anomaly-correlation-with-cmr-and-cardiopulmonary-exercise-testing
#5
Olga Hösch, Thuy-Trang Ngyuen, Peter Lauerer, Andreas Schuster, Shelby Kutty, Wieland Staab, Christina Unterberg-Buchwald, Jan M Sohns, Thomas Paul, Joachim Lotz, Michael Steinmetz
AIMS: Ebstein's anomaly (EA) involves a displaced and dysplastic tricuspid valve resulting in an atrialized portion of the right ventricle and an enlargement of the functional right ventricle and right atrium. Biomarkers targeting heart failure such as brain natriuretic peptide (BNP) or haematological parameters [haemoglobin (Hb) and haematocrit (Hct)] are upregulated in states of pulmonary hypoperfusion. We hypothesized that decreased pulmonary perfusion dependent on the stage of right heart failure is a possible mechanism in EA, and that it can be correlated with cardiac magnetic resonance (CMR) parameters...
June 2015: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/25343585/utility-of-the-physical-examination-in-detecting-pulmonary-hypertension-a-mixed-methods-study
#6
Rebecca Colman, Heather Whittingham, George Tomlinson, John Granton
INTRODUCTION: Patients with pulmonary hypertension (PH) often present with a variety of physical findings reflecting a volume or pressure overloaded right ventricle (RV). However, there is no consensus regarding the diagnostic utility of the physical examination in PH. METHODS: We conducted a systematic review of publications that evaluated the clinical examination and diagnosis of PH using MEDLINE (1946-2013) and EMBASE (1947-2013). We also prospectively evaluated the diagnostic utility of the physical examination findings...
2014: PloS One
https://www.readbyqxmd.com/read/24970467/role-of-right-ventricle-and-dynamic-pulmonary-hypertension-on-determining-%C3%AE-vo2-%C3%AE-work-rate-flattening-insights-from-cardiopulmonary-exercise-test-combined-with-exercise-echocardiography
#7
COMPARATIVE STUDY
Francesco Bandera, Greta Generati, Marta Pellegrino, Valeria Donghi, Eleonora Alfonzetti, Maddalena Gaeta, Simona Villani, Marco Guazzi
BACKGROUND: Several cardiovascular diseases are characterized by an impaired O2 kinetic during exercise. The lack of a linear increase of Δoxygen consumption (VO2)/ΔWork Rate (WR) relationship, as assessed by expired gas analysis, is considered an indicator of abnormal cardiovascular efficiency. We aimed at describing the frequency of ΔVO2/ΔWR flattening in a symptomatic population of cardiac patients, characterizing its functional profile, and testing the hypothesis that dynamic pulmonary hypertension and right ventricular contractile reserve play a major role as cardiac determinants...
September 2014: Circulation. Heart Failure
https://www.readbyqxmd.com/read/24520280/evaluation-of-right-ventricular-function-by-doppler-tissue-imaging-of-the-tricuspid-annulus-in-patients-with-acquired-immune-deficiency-syndrome
#8
Haohui Zhu, Jianjun Yuan, Changhua Wei, Jiyun Chen, Yisa Wang
Chronic heart disease contributes to the mortality of patients with AIDS. Although studies of left ventricular function in patients with acquired immune deficiency syndrome (AIDS) have been conducted, studies of right ventricular function are rare. The present study aimed to characterize the tricuspid annulus movement and evaluate the right ventricular function of patients with AIDS by tissue Doppler imaging. Tissue Doppler echocardiography was performed on 106 patients with AIDS and 64 controls. Tricuspid annulus movements were detected from the apical four-chamber view and the apical right heart two-chamber view...
March 2014: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/21715031/peak-oxygen-uptake-correlates-with-disease-severity-and-predicts-outcome-in-adult-patients-with-ebstein-s-anomaly-of-the-tricuspid-valve
#9
Jelena Radojevic, Ryo Inuzuka, Rafael Alonso-Gonzalez, Francesco Borgia, Georgios Giannakoulas, Matina Prapa, Emmanouil Liodakis, Wei Li, Lorna Swan, Gerhard Paul Diller, Konstantinos Dimopoulos, Michael A Gatzoulis
BACKGROUND: Ebstein's anomaly of the tricuspid valve often results in biventricular dysfunction and functional deterioration. Little is known about the relation between exercise capacity, disease severity and outcome in adults with Ebstein's anomaly. METHODS: Data on all patients with Ebstein's anomaly of the tricuspid valve who underwent cardiopulmonary exercise testing in our tertiary center were collected. The relation between exercise parameters, anatomic severity (Glasgow outcome score) and the combined end-point of death, non-elective hospitalization and surgical repair was studied using Cox regression analysis...
March 10, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/21093874/improvements-in-exercise-performance-after-surgery-for-ebstein-anomaly
#10
Jan Müller, Andreas Kühn, Manfred Vogt, Christian Schreiber, John Hess, Alfred Hager
OBJECTIVE: The purpose of this longitudinal study was to assess improvements in exercise performance and quality of life in patients with Ebstein anomaly after surgical intervention. METHODS: In 21 patients with Ebstein anomaly (between 6 and 59 years of age; 16 female, 5 male) who underwent surgery for tricuspid regurgitation and, if present, closure of an interatrial shunt, a cardiopulmonary exercise test and a quality-of-life assessment by the Medical Outcomes Study 36 item short form was performed prior to and 6 to 18 months after surgery...
May 2011: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/20688926/ventilatory-inefficiency-reflects-right-ventricular-dysfunction-in-systolic-heart-failure
#11
COMPARATIVE STUDY
Amanda B Methvin, Anjali T Owens, Anthony G Emmi, Michael Allen, Susan E Wiegers, Daniel L Dries, Kenneth B Margulies, Paul R Forfia
BACKGROUND: An increased minute ventilation (VE)/carbon dioxide production (VCO2) relationship, an expression of ventilatory inefficiency (VI), is associated with increased morbidity and mortality in patients with left ventricular systolic dysfunction (LVSD). A direct link between VI and a specific cardiac abnormality has not been established. METHODS: We analyzed cardiopulmonary exercise test (CPET) data from patients (N=83) with severe LVSD (ischemic and nonischemic; left ventricular ejection fraction [LVEF] 19%±7%) and at least moderate exercise intolerance...
March 2011: Chest
https://www.readbyqxmd.com/read/20634432/tetralogy-of-fallot-3d-velocity-encoded-mr-imaging-for-evaluation-of-right-ventricular-valve-flow-and-diastolic-function-in-patients-after-correction
#12
Annelies E van der Hulst, Jos J M Westenberg, Lucia J M Kroft, Jeroen J Bax, Nico A Blom, Albert de Roos, Arno A W Roest
PURPOSE: To evaluate three-dimensional (3D) velocity-encoded (VE) magnetic resonance (MR) imaging, as compared with two-dimensional (2D) VE MR imaging, for assessment of pulmonary valve (PV) and tricuspid valve (TV) flow, with planimetry as the reference standard, and to evaluate diastolic function in patients with a corrected tetralogy of Fallot (TOF). MATERIALS AND METHODS: Local institutional review board approval was obtained, and patients or their parents gave informed consent...
September 2010: Radiology
https://www.readbyqxmd.com/read/19766331/exercise-intolerance-in-patients-with-congenitally-corrected-transposition-of-the-great-arteries-relates-to-right-ventricular-filling-pressures
#13
Edgar L W Tay, Alexandra Frogoudaki, Ryo Inuzuka, Georgios Giannakoulas, Matina Prapa, Wei Li, George Pantely, Konstantinos Dimopoulos, Michael A Gatzoulis
BACKGROUND: Patients with congenitally corrected transposition of the great arteries (ccTGA) have significantly reduced exercise tolerance. Progressive right ventricular (RV) dysfunction with tricuspid regurgitation (TR) and other haemodynamic lesions are common among them. We hypothesised that interaction of these factors may result in increased systemic RV filling pressure, which in turn impact on exercise capacity. METHODS: Patients with ccTGA in functional class I or II, able to perform treadmill exercise and without resting cyanosis were enrolled...
March 3, 2011: International Journal of Cardiology
https://www.readbyqxmd.com/read/19724233/flow-assessment-through-four-heart-valves-simultaneously-using-3-dimensional-3-directional-velocity-encoded-magnetic-resonance-imaging-with-retrospective-valve-tracking-in-healthy-volunteers-and-patients-with-valvular-regurgitation
#14
Stijntje D Roes, Sebastiaan Hammer, Rob J van der Geest, Nina Ajmone Marsan, Jeroen J Bax, Hildo J Lamb, Johan H C Reiber, Albert de Roos, Jos J M Westenberg
OBJECTIVES: To validate 3-dimensional (3D) 3-directional velocity-encoded (VE) magnetic resonance imaging (MRI) for flow assessment through all 4 heart valves simultaneously with retrospective valve-tracking during off-line analysis in healthy volunteers and in patients with valvular regurgitation. MATERIAL AND METHODS: Three-dimensional 3-directional VE MRI was performed in 22 healthy volunteers and in 29 patients with ischemic cardiomyopathy who were suspected of valvular regurgitation and net flow volumes through the 4 heart valves were compared...
October 2009: Investigative Radiology
https://www.readbyqxmd.com/read/18849503/mitral-valve-and-tricuspid-valve-blood-flow-accurate-quantification-with-3d-velocity-encoded-mr-imaging-with-retrospective-valve-tracking
#15
COMPARATIVE STUDY
Jos J M Westenberg, Stijntje D Roes, Nina Ajmone Marsan, Nico M J Binnendijk, Joost Doornbos, Jeroen J Bax, Johan H C Reiber, Albert de Roos, Robert J van der Geest
PURPOSE: To validate flow assessment performed with three-dimensional (3D) three-directional velocity-encoded (VE) magnetic resonance (MR) imaging with retrospective valve tracking and to compare this modality with conventional two-dimensional (2D) one-directional VE MR imaging in healthy subjects and patients with regurgitation. MATERIALS AND METHODS: Patients and volunteers gave informed consent, and local medical ethics committee approval was obtained. Patient data were selected retrospectively and randomly from a database of MR studies obtained between July 2006 and July 2007...
December 2008: Radiology
https://www.readbyqxmd.com/read/18545065/right-heart-dysfunction-assessed-with-echography-b-type-natriuretic-peptide-and-cardiopulmonary-test-in-patients-with-chronic-heart-failure
#16
Federica Troisi, Stefania Greco, Natale Daniele Brunetti, Matteo Di Biase
BACKGROUND: Right ventricle (RV) impairment could influence brain natriuretic peptide (BNP) circulating levels. It is not well known whether echocardiographic parameters assessing RV function could be related to BNP levels in patients with chronic heart failure (CHF). Controversial data are available about the role played by RV dysfunction in determining exercise capacity in CHF patients. METHODS: Sixty patients with CHF referred to our CHF Unit underwent blood sampling for BNP levels determination, cardiopulmonary exercise test with VO2 peak, VO2-AT and VE/VCO2 slope assessment and M-mode, two-dimensional and Doppler echocardiography with evaluation of right heart function [right atrial pressure (RAP), pulmonary artery pressure (PAP), severity of tricuspid regurgitation (TR), and tricuspid annular plane systolic excursion (TAPSE)]...
July 2008: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/18021534/-evaluation-of-right-ventricular-function-by-quantitative-tissue-velocity-imaging-and-tissue-tracking-imaging-in-neonates-with-congenital-hypothyroidism
#17
Shan-shan Mao, Jing-jing Ye, Guo-ping Jiang, Zheng-yan Zhao
OBJECTIVE: Although several reports documented the association of congenital hypothyroidism (CH) and left ventricular (LV) function in infants or neonates, right ventricular (RV) function in neonates with CH has not been previously studied. The aim of the present study was to assess RV function in neonates with CH before and after thyroxine substitution therapy by quantitative tissue velocity imaging (QTVI) and tissue tracking imaging (TTI). METHODS: Fifty-two neonates aged 18-28 days (25 males and 27 females) with CH and 35 healthy neonates aged 18-28 days (16 males and 19 females) were studied by QTVI, TTI as well as conventional pulsed-wave Doppler echocardiography (PWD)...
August 2007: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/17924550/pulmonary-hypertension-of-sickle-cell-disease-more-than-just-another-lung-disease
#18
EDITORIAL
Elizabeth S Klings
Pulmonary hypertension (PH) of sickle cell disease (SCD), as defined by a tricuspid regurgitant jet velocity by echocardiogram of >or=2.5 m/sec, occurs in approximately 1/3 of HbSS adults and is an independent risk factor for mortality. Although studies of the past few years have greatly expanded our knowledge of the clinical manifestations and pathogenesis of PH in SCD, many questions remain. Two of the key issues addressed by manuscripts in the issue of the American Journal of Hematology are the prevalence of PH in the large African SCD population and the association of PH with renal disease and systemic hypertension...
January 2008: American Journal of Hematology
https://www.readbyqxmd.com/read/16242194/adults-with-ebstein-s-anomaly-cardiopulmonary-exercise-testing-and-bnp-levels-exercise-capacity-and-bnp-in-adults-with-ebstein-s-anomaly
#19
Olga Trojnarska, Andrzej Szyszka, Adrian Gwizdała, Andrzej Siniawski, Zofia Oko-Sarnowska, Ewa Chmara, Ewa Straburzyńska-Migaj, Sławomir Katarzyński, Andrzej Cieśliński
INTRODUCTION: Ebstein's anomaly is defined as the significant apical displacement of the part of the tricuspid valve causing significant tricuspid regurgitation and reduction of the functional right ventricle. The aim of the study was to evaluate exercise capacity with cardiopulmonary stress testing and to determine plasma BNP levels in adults with Ebstein's anomaly, and to establish their relation with echocardiogaphic grading of the lesion severity. MATERIALS AND METHODS: Study group consisted of 21 patients (16 males, aged 40...
July 28, 2006: International Journal of Cardiology
https://www.readbyqxmd.com/read/8261053/doppler-stress-echocardiography-of-the-left-and-right-ventricle-a-new-echo-device-to-quantify-left-ventricular-backward-failure
#20
T Bartel, S Müller, A C Borges, A Förster
OBJECTIVES: A novel non-invasive procedure which evaluates left-right ventricular interaction is introduced. This procedure is suitable for the classification of congestive heart failure. METHODS: In 48 patients showing mild, moderate or advanced stage congestive heart failure (NYHA I-III) Doppler echocardiography was performed at rest, during and after submaximal bicycle exercise. Mitral (m) and tricuspid (t) filling parameters were determined: early diastolic (VEm, VEt) and atrial maximal velocities (VAm, VAt), the velocity integrals (Em, Et, Am, At) and the corresponding ratios (VE/VAm, VE/VAt, E/Am, E/At)...
March 1993: European Journal of Medicine
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