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Cardiology, electrophysiology, cardiac device therapy, Heart failure

Alastair Gray, Conor McQuillan, Ian B A Menown
INTRODUCTION: The findings of many new cardiology clinical trials over the last year have been published or presented at major international meetings. This paper aims to describe and place in context a summary of the key clinical trials in cardiology presented between January and December 2016. METHODS: The authors reviewed clinical trials presented at major cardiology conferences during 2016 including the American College of Cardiology (ACC), European Association for Percutaneous Cardiovascular Interventions (EuroPCR), European Society of Cardiology (ESC), European Association for the Study of Diabetes (EASD), Transcatheter Cardiovascular Therapeutics (TCT), and the American Heart Association (AHA)...
July 2017: Advances in Therapy
Patrizia Carità, Egle Corrado, Gianluca Pontone, Antonio Curnis, Angela Nogara, Antonino Mignano, Massimo Verdecchia, Gianfranco Ciaramitaro, Salvatore Novo, Giuseppe Coppola
Cardiac resynchronization therapy (CRT) has been shown as a successful strategy in the treatment of patients with heart failure and electrical dyssincrony. However, a significant proportion of implanted patients fails to respond sufficiently or in a predictable manner. Consequently, non response to CRT remains a valuable problem in clinical practice. In order to improve CRT response and long-term clinical benefits, the proper evaluation of patient's global frialty, the technology improvement, the multimodality imaging approach and the use of simple and low cost electrographic parameters (to verify effective biventricular capture and QRS narrowing) could play a important role...
January 2017: Recenti Progressi in Medicina
Agnieszka Liberska, Oskar Kowalski, Michał Mazurek, Radosław Lenarczyk, Ewa Jędrzejczyk-Patej, Katarzyna Przybylska-Siedlecka, Monika Kozieł, Stanisław Morawski, Tomasz Podolecki, Jacek Kowalczyk, Patrycja Pruszkowska, Sławomir Pluta, Adam Sokal, Zbigniew Kalarus
BACKGROUND: Due to the recent rapid increase in the number of patients implanted with pacemakers, cardioverter-defibrillators (ICD), and cardiac resynchronisation therapy devices (CRT), conventional monitoring at specialist clinics is becoming increasingly difficult. The development of technology has enabled remote device monitoring with the use of teletransmission systems. AIM: To assess the effectiveness of transmission and the possibility of using telemetric data for further clinical management of patients with heart failure (HF) treated with CRT-D...
2016: Kardiologia Polska
Deirdre M Mooney, Erik Fung, Rahul N Doshi, David M Shavelle
Heart failure (HF) is a costly, challenging and highly prevalent medical condition. Hospitalization for acute decompensation is associated with high morbidity and mortality. Despite application of evidence-based medical therapies and technologies, HF remains a formidable challenge for virtually all healthcare systems. Repeat hospitalizations for acute decompensated HF (ADHF) can have major financial impact on institutions and resources. Early and accurate identification of impending ADHF is of paramount importance yet there is limited high quality evidence or infrastructure to guide management in the outpatient setting...
2015: Frontiers in Physiology
Elham Kayvanpour, Tommaso Mansi, Farbod Sedaghat-Hamedani, Ali Amr, Dominik Neumann, Bogdan Georgescu, Philipp Seegerer, Ali Kamen, Jan Haas, Karen S Frese, Maria Irawati, Emil Wirsz, Vanessa King, Sebastian Buss, Derliz Mereles, Edgar Zitron, Andreas Keller, Hugo A Katus, Dorin Comaniciu, Benjamin Meder
BACKGROUND: Despite modern pharmacotherapy and advanced implantable cardiac devices, overall prognosis and quality of life of HF patients remain poor. This is in part due to insufficient patient stratification and lack of individualized therapy planning, resulting in less effective treatments and a significant number of non-responders. METHODS AND RESULTS: State-of-the-art clinical phenotyping was acquired, including magnetic resonance imaging (MRI) and biomarker assessment...
2015: PloS One
Peter McKavanagh, Claire McCune, Ian B Menown
INTRODUCTION: Over the last year, multiple, potentially practice-changing, cardiology trials or studies have been published or presented at international meetings including the American College of Cardiology, European Association for Percutaneous Cardiovascular Interventions, European Society of Cardiology, Transcatheter Cardiovascular Therapeutics, Heart Failure Congress, Heart Rhythm Society, Heart Failure Society of America, American Society of Hypertension and the American Heart Association...
June 2015: Cardiology and Therapy
Karl Heinz Kuck, Gerhard Hindricks
The Year in Cardiology 'arrhythmias' presents an update on the latest studies and innovations published in the field within the last 12 months. Recent advances in the management of atrial fibrillation and novel treatment strategies and technologies are presented. New consensus documents to improve the diagnosis and treatment of patients with inherited cardiac arrhythmias and for paediatric patients with cardiac arrhythmias are summarized. Great progress has also been made in the field of cardiac implantable electronic devices: improvements in implantation techniques and novel technologies have been introduced and successfully applied...
February 2014: European Heart Journal
Ata Soleimani Rahbar, Jonathan C Hsu, Frederick T Han, NhuNhu Nguyen, Minkyung Kwon, Peyman N Azadani, Gregory M Marcus, Byron K Lee
BACKGROUND: The "July phenomenon" describes poor patient outcomes in teaching hospitals at the beginning of a new academic year when trainees begin. Whether this phenomenon truly exists is unclear. OBJECTIVE: The purpose of this study was to identify whether trainee and attending inexperience is associated with cardiac electrophysiologic procedural outcomes including total procedure time, fluoroscopy time, and complications. METHODS: We retrospectively reviewed the available electronic records of 488 consecutive patients undergoing initial dual-chamber pacemaker (PM) or cardiac resynchronization therapy (CRT) device implantation performed at University of California, San Francisco from February 2004 through November 2011...
December 2013: Heart Rhythm: the Official Journal of the Heart Rhythm Society
O Muller, C Trana, Y Roux, E Pruvot, D Graf, X Jeanrenaud, D Locca, P Vogt
The present review provides a selected choice of clinical research in the field of interventional cardiology, electrophysiology and cardiac imaging. We also focused on the new guidelines published by the European society of cardiology in 2010 (revascularization, atrial fibrillation and device therapy in heart failure).
January 12, 2011: Revue Médicale Suisse
Sana M Al-Khatib, Gillian D Sanders, Mark Carlson, Aida Cicic, Anne Curtis, Gregg C Fonarow, Peter W Groeneveld, David Hayes, Paul Heidenreich, Daniel Mark, Eric Peterson, Eric N Prystowsky, Philip Sager, Marcel E Salive, Kevin Thomas, Clyde W Yancy, Wojciech Zareba, Douglas Zipes
Because the burden of sudden cardiac death (SCD) is substantial, it is important to use all guideline-driven therapies to prevent SCD. Among those therapies is the implantable cardioverter defibrillator (ICD). When indicated, ICD use is beneficial and cost-effective. Unfortunately, studies suggest that most patients who have indications for this therapy for primary or secondary prevention of SCD are not receiving it. To explore potential reasons for this underuse and to propose potential facilitators for ICD dissemination, the Duke Center for the Prevention of SCD at the Duke Clinical Research Institute (Durham, NC) organized a think tank meeting of experts on this issue...
October 2008: American Heart Journal
Ayesha Hasan, Clyde W Yancy
With the rise in the use of device therapy implants, we are better identifying appropriate chronic heart failure patients for primary implantable defibrillator therapy who are at risk of ventricular arrhythmia. As our knowledge expands, however, controversial issues emerge. Guidelines have been endorsed by the major international societies, such as the American College of Cardiology (ACC), the American Heart Association (AHA), and the European Society of Cardiology. In view of certain variances in recommendations and new data, a recent joint guideline statement has been issued from these 3 societies regarding management of ventricular arrhythmia and preventing sudden cardiac death in patients with left ventricular dysfunction and heart failure...
July 2007: Congestive Heart Failure
Giuseppe Boriani, Igor Diemberger, Mauro Biffi, Cristian Martignani, Cinzia Valzania, Matteo Ziacchi, Matteo Bertini, Salvatore Specchia, Francesco Grigioni, Claudio Rapezzi, Angelo Branzi
Considering the relatively short history of cardiac resynchronization therapy (CRT), the amount of available evidence of efficacy is impressive, and effectiveness studies are now required. Transfer of our experimentally gained knowledge into the real world raises issues that call for synchronization among the many specialists involved in chronic heart failure (CHF) management and CRT decision making. From an economic perspective, the demonstrated ability of CRT to reduce hospitalizations could help ease the burden on health systems derived from the growing incidence of CHF...
December 2006: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Kathryn A Glatter, J Nilas Young, Matthew D McElvany
Implantable cardioverter-defibrillator (ICD or defibrillator) therapy has revolutionized the fields of cardiology and electrophysiology. Hundreds of thousands of patients at risk for sudden cardiac death receive them each year. The devices are not much larger than a pacemaker, and they have full pacemaker capabilities in addition to being able to shock patients out of life-threatening ventricular arrhythmias. The Multicenter Automatic Defibrillator Implantation Trial (MADIT) in 1996 was a landmark trial that showed for the first time a mortality benefit of ICD therapy over medications in patients at high risk for sudden death...
2006: Preventive Cardiology
David S Cannom, Morton Mower
BACKGROUND: The two major modes of death in the patient with a reduced ejection fraction (EF) are death due to heart failure and death due to lethal arrhythmia, essentially the two sides of the same coin. Over the last 20 years, two therapies-cardiac resynchronization therapy (CRT) and the implantable cardioverter defibrillator (ICD)-have been developed and tested in clinical trials. They are now, in conjunction with appropriate medical therapy, the mainstays of therapy for these two commonly encountered clinical problems...
October 2005: Annals of Noninvasive Electrocardiology
Giovanni Luca Botto, Alessandro Proclemer, Mario Luzi, Franco Ruffa, Maria Grazia Gorgoglione, Giovanni Ferrari
Sudden cardiac death accounts for 400,000 to 450,000 deaths annually in Europe and in the United States. In patients with previous life-threatening arrhythmia, several perspective, randomized, controlled studies have demonstrated that implantable cardioverter-defibrillator (ICD) therapy is superior to the best antiarrhythmic therapy in prolonging survival. Furthermore, in a stratified-risk population with coronary artery disease, left ventricular ejection fraction < or = 35%, non-sustained ventricular arrhythmias, and inducible ventricular tachycardia, the ICD supports the class I level of recommendation by the guidelines published in 1998...
March 2005: Italian Heart Journal: Official Journal of the Italian Federation of Cardiology
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