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https://www.readbyqxmd.com/read/28632492/is-the-location-of-the-signal-intensity-weighted-centroid-a-reliable-measurement-of-fluid-displacement-within-the-disc
#1
Vahid Abdollah, Eric C Parent, Michele C Battié
Degenerated discs have shorter T2-relaxation time and lower MR signal. The location of the signal-intensity-weighted-centroid reflects the water distribution within a region-of-interest (ROI). This study compared the reliability of the location of the signal-intensity-weighted-centroid to mean signal intensity and area measurements. L4-L5 and L5-S1 discs were measured on 43 mid-sagittal T2-weighted 3T MRI images in adults with back pain. One rater analysed images twice and another once, blinded to measurements...
June 20, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28621701/epigenetics-insights-into-chronic-pain-dna-hypomethylation-in-fibromyalgia-a-controlled-pilot-study
#2
Daniel Ciampi de Andrade, Mariana Maschietto, Ricardo Galhardoni, Gisele Gouveia, Thais Chile, Ana C Victorino Krepischi, Camila S Dale, André R Brunoni, Daniella C Parravano, Ana S Cueva Moscoso, Irina Raicher, Helena H S Kaziyama, Manoel J Teixeira, Helena P Brentani
To evaluate changes in DNA methylation profiles in patients with fibromyalgia (FM) compared to matched healthy controls (HCs). All individuals underwent full clinical and neurophysiological assessment by cortical excitability (CE) parameters measured by transcranial magnetic stimulation. DNA from the peripheral blood of patients with FM (n = 24) and HC (n = 24) were assessed using the Illumina-HumanMethylation450 BeadChips. We identified 1610 differentially methylated positions (DMPs) in patients with FM displaying a nonrandom distribution in regions of the genome...
June 15, 2017: Pain
https://www.readbyqxmd.com/read/28621061/biomarkers-for-urological-chronic-pelvic-pain-is-there-light-at-the-end-of-the-tunnel
#3
EDITORIAL
J Curtis Nickel
No abstract text is available yet for this article.
July 2017: BJU International
https://www.readbyqxmd.com/read/28621059/biomarkers-in-chronic-pelvic-pain-syndrome-did-we-find-the-holy-grail
#4
EDITORIAL
Thomas M Kessler
No abstract text is available yet for this article.
July 2017: BJU International
https://www.readbyqxmd.com/read/28619301/the-effects-of-gua-sha-on-symptoms-and-inflammatory-biomarkers-associated-with-chronic-low-back-pain-a-randomized-active-controlled-crossover-pilot-study-in-elderly
#5
John W M Yuen, William W N Tsang, Sonny H M Tse, Wings T Y Loo, Suk-Tak Chan, Diana L Y Wong, Hilary H Y Chung, Jacky K K Tam, Thomas K S Choi, Vico C L Chiang
OBJECTIVE: To address the challenges for trialing with elderly and the lacking of valid sham/placebo control, a randomized crossover pilot study is designed and its feasibility on elderly subjects is evaluated. DESIGN: A pilot randomized crossover study was conducted with hydrocollator-based hot pack therapy as active control. Pain intensity, physical disability, depression, general health status, and salivary biomarkers were assessed as outcome measures. RESULTS: Despite there was no significant difference observed between any outcome measures attained by the two interventions, several important differences were noted during the one-week follow-up period...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28615730/pain-in-ankylosing-spondylitis-a-neuro-immune-collaboration
#6
REVIEW
Katayoon Bidad, Eric Gracey, Kasey S Hemington, Josiane C S Mapplebeck, Karen D Davis, Robert D Inman
Clinicians have commonly differentiated chronic back pain into two broad subsets: namely, non-inflammatory (or mechanical) back pain and inflammatory back pain. As the terminology suggests, the latter category, in which ankylosing spondylitis (AS) is prominent, presupposes a close link between pain and inflammation. Advances in research into the genetics and immunology of AS have improved our understanding of the inflammatory processes involved in this disease, and have led to the development of potent anti-inflammatory biologic therapeutic agents...
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28614857/combined-effect-of-the-pgr-331c%C3%A2-%C3%A2-t-cyp17a1-34a%C3%A2-%C3%A2-g-and-cyp19a1-1531g%C3%A2-%C3%A2-a-polymorphisms-on-the-risk-of-developing-endometriosis
#7
Jéssica Vilarinho Cardoso, Daniel Escorsim Machado, Renato Ferrari, Mayara Calixto da Silva, Plínio Tostes Berardo, Jamila Alessandra Perini
Purpose To evaluate the magnitude of the association of the polymorphisms of the genes PGR, CYP17A1 and CYP19A1 in the development of endometriosis. Methods This is a retrospective case-control study involving 161 women with endometriosis (cases) and 179 controls. The polymorphisms were genotyped by real-time polymerase chain reaction using the TaqMan system. The association of the polymorphisms with endometriosis was evaluated using the multivariate logistic regression. Results The endometriosis patients were significantly younger than the controls (36...
June 14, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28603768/consensus-guidelines-for-lumbar-puncture-in-patients-with-neurological-diseases
#8
Sebastiaan Engelborghs, Ellis Niemantsverdriet, Hanne Struyfs, Kaj Blennow, Raf Brouns, Manuel Comabella, Irena Dujmovic, Wiesje van der Flier, Lutz Frölich, Daniela Galimberti, Sharmilee Gnanapavan, Bernhard Hemmer, Erik Hoff, Jakub Hort, Ellen Iacobaeus, Martin Ingelsson, Frank Jan de Jong, Michael Jonsson, Michael Khalil, Jens Kuhle, Alberto Lleó, Alexandre de Mendonça, José Luis Molinuevo, Guy Nagels, Claire Paquet, Lucilla Parnetti, Gerwin Roks, Pedro Rosa-Neto, Philip Scheltens, Constance Skårsgard, Erik Stomrud, Hayrettin Tumani, Pieter Jelle Visser, Anders Wallin, Bengt Winblad, Henrik Zetterberg, Flora Duits, Charlotte E Teunissen
INTRODUCTION: Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. METHODS: We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III)...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28602782/associations-between-serum-ghrelin-and-knee-symptoms-joint-structures-and-cartilage-or-bone-biomarkers-in-patients-with-knee-osteoarthritis
#9
J Wu, K Wang, J Xu, G Ruan, Q Zhu, J Cai, J Ren, S Zheng, Z Zhu, P Otahal, C Ding
OBJECTIVE: The roles of ghrelin in knee osteoarthritis (OA) are unclear. This study aimed to examine cross-sectional associations of ghrelin with knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee OA. METHODS: This study included 146 patients with symptomatic knee OA. Serum levels of ghrelin and cartilage or bone biomarkers including cartilage oligomeric matrix protein (COMP), cross linked C-telopeptide of type I collagen (CTXI), cross linked N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), and matrix metalloproteinase (MMP)-3, 10, 13 were measured using Enzyme-linked immunosorbent assay (ELISA)...
June 15, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28602553/proteomic-profiling-of-the-brain-of-mice-with-experimental-cerebral-malaria
#10
Ehab Moussa, Honglei Huang, Malika Ahras, Amar Lall, Marie L Thezenas, Roman Fischer, Benedikt M Kessler, Arnab Pain, Oliver Billker, Climent Casals-Pascual
Cerebral malaria (CM) is a severe neurological complication of malaria infection in both adults and children. In pursuit of effective treatment of CM, clinical studies, postmortem analysis and animal models have been employed to understand the pathology and identify effective interventions. In this study, a shotgun proteomics analysis was conducted to profile the proteomic signature of the brain tissue of mice with experimental cerebral malaria (ECM) in order to further understand the underlying pathology. To identify CM-associated response, proteomic signatures of the brains of C57/Bl6N mice infected with P...
June 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28600519/alterations-in-the-inflammatory-cytokines-and-brain-derived-neurotrophic-factor-contribute-to-depression-like-phenotype-after-spared-nerve-injury-improvement-by-ketamine
#11
Ze-Min Xie, Xing-Ming Wang, Ning Xu, Jing Wang, Wei Pan, Xiao-Hui Tang, Zhi-Qiang Zhou, Kenji Hashimoto, Jian-Jun Yang
Although pain is frequently accompanied with depression, little is known about the risk factors contributing to individual differences to the comorbidity of pain and depression. In this study, we examined whether cytokines and brain-derived neurotrophic factor (BDNF) might contribute to the individual differences in the development of neuropathic pain-induced depression. Rats were randomly subjected to spared nerved ligation (SNI) or sham surgery. The SNI rats were divided into two groups by the data from depression-related behavioral tests...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28599034/a-prospective-randomized-controlled-two-arm-clinical-study-evaluating-the-efficacy-of-a-bioelectric-dressing-system-for-blister-management-in-us-army-ranger-recruits
#12
Greggory J Housler, Sue Cross, Vanessa Marcel, Daniel O Kennedy, Michael Husband, Andrew Register, Thomas Roberts, Seth Grubbs, Douglas Dudewicz, Nathan Setka, Curt Bay, Martin E Wendelken, Mina J Izadjoo
This study focused on a clinically relevant healthcare problem in the military: acute soft tissue wounds, or blisters. The trial was a prospective, controlled, randomized two-arm study evaluating the efficacy of a bioelectric dressing, Procellera®, applied topically two to three times per week for 2 weeks to blisters developed in Ranger trainees during training at Fort Benning, Georgia. A total of 80 US Army Ranger recruits with blister wounds below the knee were randomly assigned to one of two treatment groups (n = 40/group)...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28591802/systemic-inflammatory-and-th17-immune-activation-among-patients-treated-for-lumbar-radiculopathy-exceeds-that-of-patients-treated-for-persistent-postoperative-neuropathic-pain
#13
Mohammed F Shamji, Daipayan Guha, Darcia Paul, Alina Shcharinsky
BACKGROUND: The pathophysiology of lumbar radiculopathy includes both mechanical compression and biochemical irritation of apposed neural elements. Inflammatory and immune cytokines have been implicated, induced by systemic exposure of immune-privileged intervertebral disc tissue. Surgical intervention provides improved symptoms and quality of life, but persistent postoperative neuropathic pain (PPNP) afflicts a significant fraction of patients. OBJECTIVE: To compare the inflammatory and immune phenotypes among patients undergoing structural surgery for lumbar radiculopathy and spinal cord stimulation for neuropathic pain...
June 7, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28584189/the-efficacy-of-motivational-counselling-and-sms-reminders-on-daily-sitting-time-in-patients-with-rheumatoid-arthritis-a-randomised-controlled-trial
#14
Tanja Thomsen, Mette Aadahl, Nina Beyer, Merete Lund Hetland, Katrine Løppenthin, Julie Midtgaard, Robin Christensen, Mikkel Østergaard, Poul Jørgen Jennum, Bente Appel Esbensen
OBJECTIVES: The aim of this report is to investigate the efficacy of an individually tailored, theory-based behavioural intervention for reducing daily sitting time, pain and fatigue, as well as improving health-related quality of life, general self-efficacy, physical function and cardiometabolic biomarkers in patients with rheumatoid arthritis (RA). METHODS: In this randomised controlled trial 150 patients with RA were randomised to an intervention or a no-intervention control group...
June 5, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28576734/protocol-for-the-match-study-mindfulness-and-tai-chi-for-cancer-health-a-preference-based-multi-site-randomized-comparative-effectiveness-trial-cet-of-mindfulness-based-cancer-recovery-mbcr-vs-tai-chi-qigong-tcq-for-cancer-survivors
#15
Linda E Carlson, Erin L Zelinski, Michael Speca, Lynda G Balneaves, Jennifer M Jones, Daniel Santa Mina, Peter M Wayne, Tavis S Campbell, Janine Giese-Davis, Peter Faris, Jennifer Zwicker, Kamala Patel, Tara L Beattie, Steve Cole, Kirsti Toivonen, Jill Nation, Philip Peng, Bruce Thong, Raimond Wong, Sunita Vohra
PURPOSE: A growing number of cancer survivors suffer high levels of distress, depression and stress, as well as sleep disturbance, pain and fatigue. Two different mind-body interventions helpful for treating these problems are Mindfulness-Based Cancer Recovery (MBCR) and Tai Chi/Qigong (TCQ). However, while both interventions show efficacy compared to usual care, they have never been evaluated in the same study or directly compared. This study will be the first to incorporate innovative design features including patient choice while evaluating two interventions to treat distressed cancer survivors...
May 30, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28576296/biological-determinants-of-health-genes-microbes-and-metabolism-exemplars-of-nursing-science
#16
Erin P Ferranti, Ruth Grossmann, Angela Starkweather, Margaret Heitkemper
BACKGROUND: Increasingly, nurse scientists are incorporating "omics" measures (e.g., genomics, transcriptomics, proteomics, and metabolomics) in studies of biologic determinants of health and behavior. The role of omics in nursing science can be conceptualized in several ways: (a) as a portfolio of biological measures (biomarkers) to monitor individual risk, (b) as a set of combined data elements that can generate new knowledge based on large and complex patient data sets, (c) as baseline information that promotes health education and potentially personalized interventions, and (d) as a platform to understand how environmental parameters (e...
April 12, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28572711/buprenorphine-alters-inflammatory-and-oxidative-stress-molecular-markers-in-arthritis
#17
Mahadevappa Hemshekhar, Vidyanand Anaparti, Carol Hitchon, Neeloffer Mookherjee
Buprenorphine is recommended for use as an analgesic in animal models including in murine models of collagen-induced arthritis (CIA). However, the effect of buprenorphine on the expression of disease-associated biomarkers is not well defined. We examined the effect of buprenorphine administration on disease progression and the expression of inflammatory and oxidative stress markers, in a murine model of CIA. Buprenorphine administration altered the expression of cytokines, IFN-γ, IL-6, and MMP-3, and oxidative markers, for example, iNOS, superoxide dismutase (SOD1), and catalase (CAT), in the CIA mice...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28569569/nonsteroidal-anti-inflammatory-drugs-and-cardiovascular-safety-translating-pharmacological-data-into-clinical-readouts
#18
Stefania Tacconelli, Annalisa Bruno, Rosalia Grande, Patrizia Ballerini, Paola Patrignani
The pharmacological management of pain includes the use of nonsteroidal anti-inflammatory drugs(NSAIDs). They comprise traditional(t) NSAIDs and selective cyclooxygenase(COX)-2 inhibitors (named coxibs). The analgesic and anti-inflammatory effects of NSAIDs are dependent on the extent and duration of COX-2 inhibition in the spinal cord and inflammatory sites. However, the simultaneous inhibition of COX-2 in the vasculature translates into a prothrombotic phenotype and promotes hypertension and heart failure...
June 8, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28562355/discriminating-patients-with-early-stage-breast-cancer-from-benign-lesions-by-detection-of-oxidative-dna-damage-biomarker-in-urine
#19
Cheng Guo, Xiaofen Li, Minfeng Ye, Fei Xu, Jiekai Yu, Cong Xie, Xiaoji Cao, Mengzhe Guo, Ying Yuan, Shu Zheng
Breast cancer is one of the most commonly diagnosed and death-related cancers in women worldwide. Mammography is routinely used for screening and invasive examinations such as painful tissue biopsies were recommended for patients with abnormal screening outcomes. However, a considerable proportion of these cases turn out to be benign lesions. Thus, novel non-invasive approach for discriminating breast cancer from benign lesions is desirable. Herein, we applied a high-throughput ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) analysis to determine the oxidative DNA damage biomarker, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in urine samples from 60 patients with early-stage breast cancer (stage I, II), 51 patients with benign breast diseases and 73 healthy volunteers...
May 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28554530/electrical-muscle-stimulation-induces-an-increase-of-vegfr2-on-circulating-hematopoietic-stem-cells-in-patients-with-diabetes
#20
Asa Hidmark, Ioannis Spanidis, Thomas H Fleming, Nadine Volk, Volker Eckstein, Jan B Groener, Stefan Kopf, Peter P Nawroth, Dimitrios Oikonomou
PURPOSE: External electric muscle stimulation (EMS) of the thigh muscles was found to reduce pain resulting from diabetic neuropathy (DN), a vascular complication of diabetes. This study investigated circulating hematopoietic stem cells (HSCs) after EMS treatment. Impaired function of HSCs and the subpopulation endothelial progenitor cells (EPCs), important for neovascularization and endothelial repair, has been associated with DN. METHODS: Twenty-four patients with painful DN were treated 3 times with EMS over a period of 1 week...
May 26, 2017: Clinical Therapeutics
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