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https://www.readbyqxmd.com/read/29050231/a-phase-i-study-of-foretinib-plus-erlotinib-in-patients-with-previously-treated-advanced-non-small-cell-lung-cancer-canadian-cancer-trials-group-ind-196
#1
Natasha B Leighl, Ming-Sound Tsao, Geoffrey Liu, Dongsheng Tu, Cheryl Ho, Frances A Shepherd, Nevin Murray, John R Goffin, Garth Nicholas, Shingo Sakashita, Zhuo Chen, Lucia Kim, Jean Powers, Lesley Seymour, Glenwood Goss, Penelope A Bradbury
PURPOSE: MET and AXL mediate resistance to EGFR TKI in NSCLC. Foretinib, a MET/RON/AXL/TIE-2/VEGFR kinase inhibitor may overcome EGFR kinase resistance. This dose escalation study combined foretinib and erlotinib in advanced pretreated NSCLC patients. EXPERIMENTAL DESIGN: The primary endpoint was to define the RP2D of foretinib plus erlotinib as continuous oral daily dosing. Secondary objectives included safety, pharmacokinetics, response and potential biomarkers of response including EGFR, KRAS genotype, MET, AXL expression, and circulating HGF levels...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045952/-progress-in-diagnosis-and-management-of-syncope-in-children
#2
W R Xu, Y Liao, H F Jin, Q Y Zhang, C S Tang, J B DU
Syncope is a common emergency of children and adolescents, which has serious influence on the quality of life. Neurally-mediated syncope, including postural tachycardia syndrome, vasovagal syncope, orthostatic hypotension and orthostatic hypertension, is the main cause of syncope in children and adolescents. The main manifestations of neurally-mediated syncope are diverse, such as dizziness, headache, chest tightness, chest pain, pale complexion, fatigue, pre-syncope and syncope. Although the clinical manifestations are similar, each subtype of syncope has its hemodynamic feature and optimal treatment option...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29042812/age-differences-in-salivary-markers-of-inflammation-in-response-to-experimental-pain-does-venipuncture-matter
#3
Yenisel Cruz-Almeida, Maria Aguirre, Heather Sorenson, Patrick Tighe, Shannon M Wallet, Joseph L Riley
An important consideration in mechanistic research using biomarkers should include the use of saliva as an alternative to blood. The use of saliva would allow the study of susceptible populations such as older adults where venipuncture may not be feasible. Although saliva has been most commonly used to measure cortisol and tumor necrosis factor-α (TNFα), there is limited evidence that other cytokines found in saliva significantly change in response to laboratory-induced pain. Therefore, the aim of the current preliminary study was to characterize the time course, duration and magnitude of changes of commonly measured pro- (interleukin [IL]-6, IL-8) and anti-inflammatory (IL-10, IL-4) cytokines in saliva samples and to test for age-related differences in separate experimental painful and non-painful control sessions...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29037911/assessing-daylight-low-light-photodynamic-therapy-efficacy-using-biomarkers-of-photophysical-biochemical-and-biological-damage-metrics-in-situ
#4
Ana Luiza Ribeiro de Souza, Ethan LaRochelle, Kayla Marra, Jason Gunn, Scott C Davis, Kimberley S Samkoe, M Shane Chapman, Edward V Maytin, Tayyaba Hasan, Brian W Pogue
BACKGROUND: Sunlight can activate photodynamic therapy (PDT), and this is a proven strategy to reduce pain caused by the conventional PDT treatment, but assessment of this and other alternative low dose rate light sources, and their efficacy, has not been studied in an objective, controlled pre-clinical setting. This study used three objective assays to assess the efficacy of different PDT treatment regimens, using PpIX fluorescence as a photophysical measure, STAT3 cross-linking as a photochemical measure, and keratinocyte damage as a photobiological measure...
October 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29029109/early-diagnosis-of-acute-coronary-syndrome
#5
Hugo Katus, André Ziegler, Okan Ekinci, Evangelos Giannitsis, Wendy Gattis Stough, Stephan Achenbach, Stefan Blankenberg, Martina Brueckmann, Paul Collinson, Dorin Comaniciu, Filippo Crea, Wilfried Dinh, Grégory Ducrocq, Frank A Flachskampf, Keith A A Fox, Matthias G Friedrich, Kathy A Hebert, Anders Himmelmann, Mark Hlatky, Dominik Lautsch, Bertil Lindahl, Daniel Lindholm, Nicholas L Mills, Giorgio Minotti, Martin Möckel, Torbjørn Omland, Véronique Semjonow
The diagnostic evaluation of acute chest pain has been augmented in recent years by advances in the sensitivity and precision of cardiac troponin assays, new biomarkers, improvements in imaging modalities, and release of new clinical decision algorithms. This progress has enabled physicians to diagnose or rule-out acute myocardial infarction earlier after the initial patient presentation, usually in emergency department settings, which may facilitate prompt initiation of evidence-based treatments, investigation of alternative diagnoses for chest pain, or discharge, and permit better utilization of healthcare resources...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29024470/predictive-validity-of-radiographic-trabecular-bone-texture-in-knee-oa-the-oarsi-fnih-oa-biomarkers-consortium
#6
Virginia Byers Kraus, Jamie E Collins, H Cecil Charles, Carl F Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, Steve Hoffmann, Frank Roemer, Ali Guermazi, David J Hunter
OBJECTIVE: To evaluate radiographic subchondral trabecular bone texture (TBT) as a predictor of clinically relevant osteoarthritis (OA) progression (combination of symptom and structure worsening). METHODS: The FNIH OA Biomarkers Consortium undertook a study of progressive knee OA cases (n=194 knees with both radiographic and pain progression over 24-48 months) and comparators (n=406 OA knees not meeting the case definition). TBT parameters were extracted from a medial subchondral tibial region of interest by fractal signature analysis of radiographs using a validated semi-automated software...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29018631/multi-parameter-ensemble-learning-for-automated-vertebral-body-segmentation-in-heterogeneously-acquired-clinical-mr-images
#7
Bilwaj Gaonkar, Yihao Xia, Diane S Villaroman, Allison Ko, Mark Attiah, Joel S Beckett, Luke Macyszyn
The development of quantitative imaging biomarkers in medicine requires automatic delineation of relevant anatomical structures using available imaging data. However, this task is complicated in clinical medicine due to the variation in scanning parameters and protocols, even within a single medical center. Existing literature on automatic image segmentation using MR data is based on the analysis of highly homogenous images obtained using a fixed set of pulse sequence parameters (TR/TE). Unfortunately, algorithms that operate on fixed scanning parameters do not avail themselves to real-world daily clinical use due to the existing variation in scanning parameters and protocols...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28992171/points-to-consider-for-skin-ulcers-in-systemic-sclerosis
#8
REVIEW
Felice Galluccio, Yannick Allanore, Lázló Czirjak, Daniel E Furst, Dinesh Khanna, Marco Matucci-Cerinic
This article discusses points to consider when undertaking a clinical trial to test therapy for skin ulcers in SSc. A validated definition of skin ulcers should be used if available. Defining a uniform SSc patient population, including consideration of disease duration, history of digital ulcers and capillaroscopic patterns, is important. Excluding confounding factors such as infection, calcinosis and trauma should be strongly considered, or at least accounted for, in defining patients. Outcome measures such as time to healing, prevention of new ulcers, function, pain and objective measures such as US, laser Doppler and thermography can be considered as outcome measures, although their validation has not yet been achieved and efforts may be needed to validate them before use...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28989174/new-treatment-paradigms-for-adpkd-moving-towards-precision-medicine
#9
REVIEW
Matthew B Lanktree, Arlene B Chapman
The natural history of autosomal dominant polycystic kidney disease (ADPKD) is characterized by a variable rate of cyst development and increase in total kidney volume (TKV), variable kidney function decline and age of onset of end-stage renal disease (ESRD), and variable presentation of renal and extrarenal manifestations. Precision medicine is proposed to improve patient outcomes by tailoring therapy to the specific genetic background, pathophysiology, disease burden, prognosis and status of each individual...
October 9, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28986648/acute-myocarditis-with-infarct-like-presentation-in-a-pediatric-population-role-of-cardiovascular-magnetic-resonance
#10
Maria Martinez-Villar, Ferran Gran, Anna Sabaté-Rotés, Antonio Tello-Montoliu, Amparo Castellote, Marc Figueras-Coll, Queralt Ferrer, Ferran Roses-Noguer
Chest pain is a typical symptom of acute myocarditis in adolescents. It may be indistinguishable from myocardial ischemia so it is called "infarct-like pattern." Cardiovascular magnetic resonance has an important role as a non-invasive diagnostic tool. The aim of our study is to provide a description of an acute myocarditis series with infarct-like pattern and to evaluate the cardiovascular magnetic resonance role in a pediatric population. We included all pediatric patients (0-16 years) admitted to our hospital (May 2007-May 2016) with clinical diagnosis of acute myocarditis and infarct-like presentation (chest pain, EKG alterations, and released cardiac biomarkers)...
October 6, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28986538/circulating-micrornas-a-novel-potential-biomarker-for-diagnosing-acute-aortic-dissection
#11
Jian Dong, Junmin Bao, Rui Feng, Zhiqing Zhao, Qingsheng Lu, Guokun Wang, Haiyan Li, Dingfeng Su, Jian Zhou, Qing Jing, Zaiping Jing
Acute aortic dissection (AAD) is a catastrophic emergency with high mortality and misdiagnosis rate. We aimed to determine whether circulating microRNAs allow to distinguish AAD from healthy controls and chest pain patients without AAD (CP). Plasma microRNAs expression were determined in 103 participants, including 37 AAD patients, 26 chronic aortic dissection patients, 17 healthy volunteers, 23 patients without AAD. We selected 16 microRNAs from microarray screening as candidates for further testing via qRT-PCR...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28985716/selection-of-opioids-for-cancer-related-pain-using-a-biomarker-a-randomized-multi-institutional-open-label-trial-relief-study
#12
Hiromichi Matsuoka, Junji Tsurutani, Yasutaka Chiba, Yoshihiko Fujita, Masato Terashima, Takeshi Yoshida, Kiyohiro Sakai, Yoichi Otake, Atsuko Koyama, Kazuto Nishio, Kazuhiko Nakagawa
BACKGROUND: Cancer patients experience pain that has physiological, sensory, affective, cognitive, behavioral, and sociocultural dimensions. Opioids are used in treatment of pain in patients with various types of cancer. We previously showed that the catechol-O-methyltransferase (COMT) genotype is related to the plasma level of morphine and the required dose of morphine in an exploratory prospective study. The findings showed that a group of patients with a GG single nucleotide polymorphism (SNP) rs4680 in COMT required a significantly higher dose of morphine than a non-GG group...
October 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28984313/human-models-of-migraine-short-term-pain-for-long-term-gain
#13
REVIEW
Messoud Ashina, Jakob Møller Hansen, Bára Oladóttir Á Dunga, Jes Olesen
Migraine is a complex disorder characterized by recurrent episodes of headache, and is one of the most prevalent and disabling neurological disorders. A key feature of migraine is that various factors can trigger an attack, and this phenomenon provides a unique opportunity to investigate disease mechanisms by experimentally inducing migraine attacks. In this Review, we summarize the existing experimental models of migraine in humans, including those that exploit nitric oxide, histamine, neuropeptide and prostaglandin signalling...
October 6, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28971346/combined-pet-mri-global-warming-summary-report-of-the-6th-international-workshop-on-pet-mri-march-27-29-2017-t%C3%A3-bingen-germany
#14
REVIEW
D L Bailey, B J Pichler, B Gückel, G Antoch, H Barthel, Z M Bhujwalla, S Biskup, S Biswal, M Bitzer, R Boellaard, R F Braren, C Brendle, K Brindle, A Chiti, C la Fougère, R Gillies, V Goh, M Goyen, M Hacker, L Heukamp, G M Knudsen, A M Krackhardt, I Law, J C Morris, K Nikolaou, J Nuyts, A A Ordonez, K Pantel, H H Quick, K Riklund, O Sabri, B Sattler, E G C Troost, M Zaiss, L Zender, Thomas Beyer
The 6th annual meeting to address key issues in positron emission tomography (PET)/magnetic resonance imaging (MRI) was held again in Tübingen, Germany, from March 27 to 29, 2017. Over three days of invited plenary lectures, round table discussions and dialogue board deliberations, participants critically assessed the current state of PET/MRI, both clinically and as a research tool, and attempted to chart future directions. The meeting addressed the use of PET/MRI and workflows in oncology, neurosciences, infection, inflammation and chronic pain syndromes, as well as deeper discussions about how best to characterise the tumour microenvironment, optimise the complementary information available from PET and MRI, and how advanced data mining and bioinformatics, as well as information from liquid biomarkers (circulating tumour cells and nucleic acids) and pathology, can be integrated to give a more complete characterisation of disease phenotype...
October 2, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28969626/effects-of-dietary-supplementation-with-a-standardized-aqueous-extract-of-terminalia-chebula-fruit-ayuflex-%C3%A2-on-joint-mobility-comfort-and-functional-capacity-in-healthy-overweight-subjects-a-randomized-placebo-controlled-clinical-trial
#15
H L Lopez, S M Habowski, J E Sandrock, B Raub, A Kedia, E J Bruno, T N Ziegenfuss
BACKGROUND: Joint and connective tissue integrity, comfort and function are paramount to optimal performance in exercise, recreational and occupational activities. The fruit of Terminalia chebula has been used extensively in various traditional health systems for different ailments, with additional preclinical and clinical data demonstrating antioxidant and anti-inflammatory potential. The aim of this study was to evaluate the effects of a standardized aqueous extract of Terminalia chebula fruit (AyuFlex®) dietary supplementation on joint mobility, comfort, and functional capacity in healthy overweight subjects...
October 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28965522/apical-hypertrophic-cardiomyopathy-treated-as-st-elevation-myocardial-infarction
#16
Christopher J Parr, Rajat Sharma, Philip J Garber
Electrocardiographic changes resulting from apical hypertrophic cardiomyopathy may mimic an acute coronary syndrome. A 67-year-old Sudanese male without cardiac risk factors presented to hospital with chest pain and electrocardiographic findings of septal ST-segment elevation, ST-segment depression in V4-V6, and diffuse T-wave inversion. He was treated as an acute ST-elevation myocardial infarction with thrombolytics. There was no cardiac biomarker rise and coronary angiography did not reveal evidence of significant coronary arterial disease...
October 2, 2017: CJEM
https://www.readbyqxmd.com/read/28964571/fractures-in-patients-with-ckd-diagnosis-treatment-and-prevention-a-review-by-members-of-the-european-calcified-tissue-society-and-the-european-renal-association-of-nephrology-dialysis-and-transplantation
#17
REVIEW
Ana Pimentel, Pablo Ureña-Torres, M Carola Zillikens, Jordi Bover, Martine Cohen-Solal
Mineral and bone disease is omnipresent in patients with chronic kidney disease (CKD) and leads to a diverse range of clinical manifestations, including bone pain and fractures. The accumulation of traditional clinical risk factors, in addition to those related to CKD, enhances the risk of comorbidity and mortality. Despite significant advances in understanding bone disease in CKD, most clinical and biochemical targets used in clinical practice remain controversial, resulting in an undermanagement of bone fragility...
September 27, 2017: Kidney International
https://www.readbyqxmd.com/read/28958142/serum-25-hydroxy-vitamin-d-concentration-in-acute-coronary-syndrome
#18
E Anastasi, M Suppa, V Viggiani, S Tartaglione, A Angeloni, T Granato
Vitamin D may have prognostic value in cardiovascular disease (CVD) patients and, in addition to conventional biomarkers, could be a valuable tool for disease management. The aim of this study was to assess the association of vitamin D status in patients with acute coronary syndrome (ACS) and to evaluate its prognostic utility. The levels of 25(OH) vitamin D were correlated with troponin T hs. Forty-eight consecutive outpatients (40 Caucasian and 8 Asian) aged between 40 and 70 years (mean 61.5, range 43-77 years) were enrolled in the study...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28952933/quantifying-and-characterizing-tonic-thermal-pain-across-subjects-from-eeg-data-using-random-forest-models
#19
Vishal Vijayakumar, Michelle Case, Sina Shirinpour, Bin He
OBJECTIVE: Effective pain assessment and management strategies are needed to better manage pain. In addition to self-report, an objective pain assessment system can provide a more complete picture of the neurophysiological basis for pain. In this study, a robust and accurate machine learning approach is developed to quantify tonic thermal pain across healthy subjects into a maximum of ten distinct classes. METHODS: A random forest model was trained to predict pain scores using time-frequency wavelet representations of independent components obtained from electroencephalography (EEG) data, and the relative importance of each frequency band to pain quantification is assessed...
September 25, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28949393/troponinniv%C3%A3-er-ger-nu-b%C3%A3-ttre-hj%C3%A3-lp-vid-misst%C3%A3-nkt-hj%C3%A3-rtinfarkt-l%C3%A3-ga-niv%C3%A3-er-kan-med-h%C3%A3-g-s%C3%A3-kerhet-utesluta-hj%C3%A3-rtinfarkt-%C3%A2-nya-analysmetoder-%C3%A3-kar-den-medicinska-s%C3%A3-kerheten
#20
Ola Hammarsten, Christian Bjurman, Martin Holzmann, Bertil Lindahl
Assessment of troponin levels on the emergency ward  Patients with myocardial infarction are at a high risk of sudden death and new cardiovascular events. For this reason, it is important to identify these patients and device treatment to reduce the risk. Patients who seek care with symptoms indicative of myocardial infarction, mainly chest pain, constitute a large proportion of patients at our emergency departments. However, only 5-10 % of these patients have myocardial infarction, whereas the majority has benign causes of their symptoms...
September 25, 2017: Läkartidningen
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