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https://www.readbyqxmd.com/read/29454976/defective-endogenous-pain-modulation-in-fibromyalgia-a-meta-analysis-of-temporal-summation-and-conditioned-pain-modulation-paradigms
#1
REVIEW
Anthony Terrence O'Brien, Alicia Deitos, Yolanda Triñanes Pego, Felipe Fregni, Maria Teresa Carrillo-de-la-Peña
To study the characteristics of temporal summation (TS) and conditioned pain modulation (CPM) in fibromyalgia (FM) patients, we systematically searched Pubmed and EMBASE for studies using TS or CPM comparing FM patients to healthy controls. We computed Hedge's g, risk of bias, sensitivity analysis and meta-regression tests with 10000 Monte-Carlo permutations. Twenty-three studies (625 female/23 male FM patients and 591 female/81 male healthy controls) were included. The meta-analyses showed an effect size of 0...
February 15, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29452686/technological-advances-and-changing-indications-for-lumbar-puncture-in-neurological-disorders
#2
REVIEW
Joost M Costerus, Matthijs C Brouwer, Diederik van de Beek
Technological advances have changed the indications for and the way in which lumbar puncture is done. Suspected CNS infection remains the most common indication for lumbar puncture, but new molecular techniques have broadened CSF analysis indications, such as the determination of neuronal autoantibodies in autoimmune encephalitis. New screening techniques have increased sensitvity for pathogen detection and can be used to identify pathogens that were previously unknown to cause CNS infections. Evidence suggests that potential treatments for neurodegenerative diseases, such as Alzheimer's disease, will rely on early detection of the disease with the use of CSF biomarkers...
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29445230/investigation-of-biomarkers-alterations-after-an-acute-tissue-trauma-in-human-trapezius-muscle-using-microdialysis
#3
Line Bay Sørensen, Parisa Gazerani, Karin Wåhlén, Nazdar Ghafouri, Björn Gerdle, Bijar Ghafouri
Alterations in muscle milieu are suggested as important activity of peripheral drive in patients with chronic musculoskeletal pain (CMP). Microdialysis (MD) has been used in monitoring altered metabolic response pattern in muscles. However, the insertion of MD probe causes a local tissue trauma. Whether and how metabolites in trapezius muscle are affected by acute tissue trauma is unknown. Hence, this study investigated the metabolic response and nociceptive reaction of the tissue following MD probe insertion in patients with CMP and healthy individuals...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29442401/single-arm-phase-ii-study-of-oral-vitamin-b12-for-the-treatment-of-musculoskeletal-symptoms-associated-with-aromatase-inhibitors-in-women-with-early-stage-breast-cancer
#4
Aleli Campbell, Rosalinda Heydarian, Cecilia Ochoa, Alok Kumar Dwivedi, Zeina A Nahleh
Breast cancer patients receiving endocrine therapy with aromatase Inhibitors (AIs) often experience musculoskeletal and joint-related side effects. The purpose of this study was to evaluate the effect of Vitamin B12 supplements on musculoskeletal symptoms such as pain and arthralgias induced by AIs and to correlate response with serum and inflammatory biomarkers. Upon receiving approval by the Institutional Review Board (IRB), the majority of the patients consented into the study were treated at the Texas Tech Breast Care Center...
February 14, 2018: Breast Journal
https://www.readbyqxmd.com/read/29437709/prader-willi-syndrome-a-nest-for-premature-coronary-artery-disease
#5
Diogo Rodrigues Brás, Pedro Semedo, Bruno Cordeiro Piçarra, Renato Fernandes
Individuals affected by Prader-Willi syndrome (PWS) may show increased risk for coronary artery disease (CAD), which probably relates, at least, with high burden of cardiovascular risk factors.A 27-year-old man with PWS, obesity, hypertension, diabetes mellitus and dyslipidaemia attended the emergency department with complaints of flu-like condition and chest pain. The ECG revealed a mild ST-segment elevation in inferior leads, followed by positive myocardial necrosis biomarkers. Attending to the high cardiovascular risk profile, ST-segment elevation in inferior territory and wall motion abnormalities, a coronary angiogram was performed...
February 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29435659/teenagers-and-young-adults-with-nephropathic-cystinosis-display-significant-bone-disease-and-cortical-impairment
#6
Aurélia Bertholet-Thomas, Debora Claramunt-Taberner, Ségolène Gaillard, Georges Deschênes, Elisabeth Sornay-Rendu, Pawel Szulc, Martine Cohen-Solal, Solenne Pelletier, Marie-Christine Carlier, Pierre Cochat, Justine Bacchetta
BACKGROUND: Bone impairment appears to be a novel complication of nephropathic cystinosis despite cysteamine therapy. Its exact underlying pathophysiology is nevertheless unclear. The objective of this study was to evaluate bone status among patients included in the French Crystobs study. METHODS: In addition to clinical data, bone status was evaluated using biomarkers (ALP, PTH, 25-D, 1-25D, FGF23), DXA (spine and total body), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the tibia and radius...
February 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29430406/effect-of-remote-ischemic-preconditioning-on-troponin-i-in-cabg
#7
Fatemeh Javaherforoosh Zadeh, Mohsen Moadeli, Mansoor Soltanzadeh, Farahzad Janatmakan
Background: Elective open heart surgery is associated with troponin release in some cases due to myocyte necrosis. Objectives: The aim of this study was to measure cardiac troponin I (cTnI) preoperatively in elective CABG after remote ischemic preconditioning. Methods: Twenty-eight patients were selected for elective CABG. They were randomized to receive remote ischemic preconditioning (induced by three 5-min cycles of inflation with a pneumatic tourniquet and 5-min deflation between inflation episodes as reperfusion)...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29426009/clinimetrics-of-ultrasound-pathologies-in-osteoarthritis-systematicliterature-review-and-meta-analysis
#8
REVIEW
Win Min Oo, James M Linklater, Matthew Daniel, Simo Saarakkala, Jonathan Samuels, Philip G Conaghan, Helen I Keen, Leticia A Deveza, David J Hunter
OBJECTIVE: The aims of this study were to systematically review clinimetrics of commonly assessed ultrasound pathologies in knee, hip and hand osteoarthritis (OA), and to conduct a meta-analysis for each clinimetric. METHODS: MEDLINE, EMBASE, and Cochrane Library databases were searched from their inceptions to September 2016. According to the OMERACT Instrument Selection Algorithm, data extraction focused on ultrasound technical features and performance metrics...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426008/colchicine-lack-of-effectiveness-in-symptom-and-inflammation-modification-in-knee-osteoarthritis-colkoa-a-randomized-controlled-trial
#9
Ying-Ying Leung, Benjamin Haaland, Janet L Huebner, Steven Bak-Siew Wong, Madeline Tjai, Chunyan Wang, Balram Chowbay, Julian Thumboo, Bibhas Chakraborty, Mann Hong Tan, Virginia B Kraus
OBJECTIVES: Uric acid may activate an innate immune response in osteoarthritis (OA), contributing to disease pathology and progression. We evaluated the effectiveness of colchicine on pain and function in symptomatic knee OA (KOA) and the underlying mechanism of action. METHODS: COLKOA was a double-blind, placebo-controlled, randomized trial comparing 16 weeks of treatment with 0.5 mg twice-daily oral colchicine to placebo for KOA. The primary endpoint was ≥30% improvement in total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at week 16...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29423022/comprehensive-analysis-of-gene-expression-and-dna-methylation-datasets-identify-valuable-biomarkers-for-rheumatoid-arthritis-progression
#10
Gang Fang, Qing Huai Zhang, Qianqian Tang, Zuling Jiang, Shasha Xing, Jianying Li, Yuzhou Pang
Rheumatoid arthritis (RA) represents a common systemic autoimmune disease which lays chronic and persistent pain on patients. The purpose of our study is to identify novel RA-related genes and biological processes/pathways. All the datasets of this study, including gene expression and DNA methylation datasets of RA and OA samples, were obtained from the free available database, i.e. Gene Expression Omnibus (GEO). We firstly identified the differentially expressed genes (DEGs) between RA and OA samples through the limma package of R programming software followed by the functional enrichment analysis in the Database for Annotation, Visualization and Integrated Discovery (DAVID) for the exploring of potential involved biological processes/pathways of DEGs...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29417694/inferring-distinct-mechanisms-in-the-absence-of-subjective-differences-placebo-and-centrally-acting-analgesic-underlie-unique-brain-adaptations
#11
Pascal Tétreault, Marwan N Baliki, Alexis T Baria, William R Bauer, Thomas J Schnitzer, A Vania Apkarian
Development and maintenance of chronic pain is associated with structural and functional brain reorganization. However, few studies have explored the impact of drug treatments on such changes. The extent to which long-term analgesia is related to brain adaptations and its effects on the reversibility of brain reorganization remain unclear. In a randomized placebo-controlled clinical trial, we contrasted pain relief (3-month treatment period), and anatomical (gray matter density [GMD], assessed by voxel-based morphometry) and functional connectivity (resting state fMRI nodal degree count [DC]) adaptations, in 39 knee osteoarthritis (OA) patients (22 females), randomized to duloxetine (DLX, 60 mg once daily) or placebo...
February 7, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29414033/associations-of-inflammation-with-symptom-burden-in-patients-with-acute-myeloid-leukemia
#12
Tamara E Lacourt, Annemieke Kavelaars, Jessica R Galloway-Peña, Pranoti V Sahasrabhojane, Nina D Shah, Andrew Futreal, Dimitrios P Kontoyiannis, Samuel A Shelburne, Cobi J Heijnen
The aim of the study was to assess the association inflammation with symptom burden in patients with acute myeloid leukemia (AML), assessed before and during remission induction chemotherapy (IC). Patients with AML (n = 95) were followed from baseline (before IC) to the third week of IC for severity of self-reported somatic symptoms (assessed with the MD Anderson Symptom Inventory) and plasma levels of 13 inflammation-related biomarkers (n = 64). A composite symptom burden severity score was computed as the average score of the six most severe somatic symptoms i...
February 3, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29407013/contemporary-emergency-department-management-of-patients-with-chest-pain-a-concise-review-and-guide-for-the-high-sensitivity-troponin-era
#13
REVIEW
James E Andruchow, Peter A Kavsak, Andrew D McRae
This article synthesizes current best evidence for the evaluation of patients with suspected acute coronary syndrome (ACS) using high-sensitivity troponin assays, enabling physicians to effectively incorporate them into practice. Unlike conventional assays, high-sensitivity assays can precisely measure blood cardiac troponin concentrations in the vast majority of healthy individuals, facilitating the creation of rapid diagnostic algorithms. Very low troponin concentrations on presentation accurately rule out acute myocardial infarction (AMI) and enable the discharge of approximately 20% of patients after a single test, whereas an additional 30%-40% of patients can be safely discharged after short-interval serial sampling in as little as 1 or 2 hours...
February 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29402479/advances-in-diagnostics-and-treatments-in-horses-with-acute-colic-and-postoperative-ileus
#14
REVIEW
Megan Burke, Anthony Blikslager
Differentiating between medical and surgical causes of colic is one of the primary goals of the colic workup, because early surgical intervention improves prognosis in horses requiring surgery. Despite the increasing availability of advanced diagnostics (hematologic analyses, abdominal ultrasound imaging, etc), the most accurate indicators of the need for surgery remain the presence of moderate to severe signs of abdominal pain, recurrence of pain after appropriate analgesic therapy, and the absence of intestinal borborygmi...
February 2, 2018: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/29401671/understanding-chinese-medicine-patterns-of-rheumatoid-arthritis-and-related-biomarkers
#15
REVIEW
Susana Seca, Giovanna Franconi
Background: A considerable number of Rheumatoid Arthritis (RA) patients only experience side effects from treatment, with little to no actual pain relief. The combination of disease diagnosis in biomedicine and multi-disciplinary integrative approaches such as Chinese Medicine (CM), can help to identify different functional diagnosis of RA in the context of biomarker discovery. We aimed to analyse CM patterns in RA and their biomarker profiles. Methods: Four electronic databases (web of science, CINAHL, Scopus and PubMed) were searched...
February 3, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29397354/napabucasin-versus-placebo-in-refractory-advanced-colorectal-cancer-a-randomised-phase-3-trial
#16
Derek J Jonker, Louise Nott, Takayuki Yoshino, Sharlene Gill, Jeremy Shapiro, Atsushi Ohtsu, John Zalcberg, Michael M Vickers, Alice C Wei, Yuan Gao, Niall C Tebbutt, Ben Markman, Timothy Price, Taito Esaki, Sheryl Koski, Matthew Hitron, Wei Li, Youzhi Li, Nadine M Magoski, Chiang J Li, John Simes, Dongsheng Tu, Christopher J O'Callaghan
BACKGROUND: Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3, which is a poor prognostic factor in colorectal cancer. This study aimed to test napabucasin in advanced colorectal cancer. METHODS: This study was a double-blind randomised phase 3 trial done at 68 centres in Canada, Australia, New Zealand, and Japan. Patients with advanced colorectal cancer with a good Eastern Cooperative Oncology Group (ECOG) performance status (0-1) for whom all available standard therapies had failed were eligible for the study...
January 31, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29396701/cartilage-turnover-and-intra-articular-corticosteroid-injections-in-knee-osteoarthritis
#17
Rainer Klocke, Kirsty Levasseur, George D Kitas, Jacqueline P Smith, George Hirsch
Intra-articular corticosteroid injections (IACI) are commonly used interventions for pain relief in patients with knee osteoarthritis (OA). Biomarkers may be helpful in further elucidating how IACI exert their effect. The aim of this study is to look at the response of biomarkers of cartilage and bone metabolism after IACI in knee OA. Eighty subjects with symptomatic knee OA [45% male, mean age (SD) 64 (11) years] underwent routine knee joint injection with 40 mg triamcinolone acetonide and 4 ml 1% lignocaine...
February 2, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29392240/a-tonic-heat-test-stimulus-yields-a-larger-and-more-reliable-conditioned-pain-modulation-effect-compared-to-a-phasic-heat-test-stimulus
#18
Marie Udnesseter Lie, Dagfinn Matre, Per Hansson, Audun Stubhaug, John-Anker Zwart, Kristian Bernhard Nilsen
Introduction: The interest in conditioned pain modulation (CPM) as a clinical tool for measuring endogenously induced analgesia is increasing. There is, however, large variation in the CPM methodology, hindering comparison of results across studies. Research comparing different CPM protocols is needed in order to obtain a standardized test paradigm. Objectives: The aim of the study was to assess whether a protocol with phasic heat stimuli as test-stimulus is preferable to a protocol with tonic heat stimulus as test-stimulus...
November 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29392211/women-report-higher-pain-intensity-at-a-lower-level-of-inflammation-after-knee-surgery-compared-with-men
#19
Nina Solheim, Simon Östlund, Torsten Gordh, Leiv Arne Rosseland
Introduction and Objectives: We previously found that women report more pain after knee arthroscopic procedures than men. It remains unclear whether this is due to different biochemical responses or nociceptive mechanisms. Methods: We analyzed acute pain-related inflammatory markers in a clinical model of patient self-reported pain immediately after knee surgery. To simultaneously measure 92 inflammatory biomarkers, we used the proximity extension assay with the Proseek Multiplex Inflammation I panel (Olink Bioscience, Uppsala, Sweden)...
May 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29392210/corticospinal-excitability-as-a-biomarker-of-myofascial-pain-syndrome
#20
Aurore Thibaut, Dian Zeng, Wolnei Caumo, Jianhua Liu, Felipe Fregni
Introduction: Myofascial pain syndrome (MPS) is a common chronic pain disorder that lacks effective diagnostic criteria. To better understand neurophysiological changes in chronic pain, several trials exploring corticospinal excitability in different populations of patients with chronic pain have been performed. Objectives: In this systematic review, we aimed to investigate the current literature on MPS and intracortical disinhibition, by means of increased intracortical facilitation and decreased intracortical inhibition (ICI)...
May 2017: Pain Reports (Baltimore, Md.)
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