keyword
https://read.qxmd.com/read/38368239/traumatic-lower-extremity-amputation-as-a-risk-factor-for-venous-thromboembolism
#21
JOURNAL ARTICLE
Dias Argandykov, Emanuele Lagazzi, Jefferson A Proaño-Zamudio, Wardah Rafaqat, May Abiad, Michael DeWane, Charudutt N Paranjape, Haytham M A Kaafarani, George C Velmahos, John O Hwabejire
BACKGROUND: This study aimed to evaluate whether lower extremity (LE) amputation among civilian casualties is a risk factor for venous thromboembolism. METHODS: All patients with severe LE injuries (AIS ≥3) derived from the ACS-TQIP (2013-2020) were divided into those who underwent trauma-associated amputation and those with limb salvage. Propensity score matching was used to mitigate selection bias and confounding and compare the rates of pulmonary embolism (PE) and deep vein thrombosis (DVT)...
February 13, 2024: American Journal of Surgery
https://read.qxmd.com/read/38350775/predictors-of-major-adverse-lower-limb-events-in-patients-with-tissue-loss-secondary-to-critical-limb-threatening-ischemia
#22
JOURNAL ARTICLE
Valérian Vosgin-Dinclaux, Paul Bertucat, Loubna Dari, Claire Webster, Ninon Foussard, Kamel Mohammedi, Eric Ducasse, Caroline Caradu
BACKGROUND: Chronic limb-threatening ischemia (CLTI) is the end-stage of peripheral arterial disease (PAD) posing a high risk for limb loss and mortality. This study aims to evaluate and list possible predictors of major adverse limb events (MALEs) in CLTI patients with tissue loss. METHODS: This retrospective study included all Rutherford-Becker stage 5 or 6 patients who required foot debridement and revascularization in our department from January 2016 to December 2018...
February 1, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38348364/regenerative-peripheral-nerve-interface-rpni-surgery-for-mitigation-of-neuroma-and-postamputation-pain
#23
JOURNAL ARTICLE
Christine Sw Best, Paul S Cederna, Theodore A Kung
BACKGROUND: A neuroma occurs when a regenerating transected peripheral nerve has no distal target to reinnervate. Symptomatic neuromas are a common cause of postamputation pain that can lead to substantial disability1-3 . Regenerative peripheral nerve interface (RPNI) surgery may benefit patients through the use of free nonvascularized muscle grafts as physiologic targets for peripheral nerve reinnervation for mitigation of neuroma and postamputation pain. DESCRIPTION: An RPNI is constructed by implanting the distal end of a transected peripheral nerve into a free nonvascularized skeletal muscle graft...
2024: JBJS Essential Surgical Techniques
https://read.qxmd.com/read/38345882/wound-ischemia-foot-infection-wifi-classification-system-and-its-predictive-ability-concerning-amputation-free-survival-mortality-and-major-limb-amputation-in-a-portuguese-population-a-single-center-experience
#24
JOURNAL ARTICLE
Duarte Gil Alves, Vítor Ferreira, Gabriela Teixeira, João Vasconcelos, Miguel Maia, José Vidoedo, João Almeida Pinto
INTRODUCTION: Commonly used chronic limb-threatening ischemia (CLTI) classifications lack granularity and detail to precisely stratify patients according to risk of limb loss, expected revascularization benefit and mortality. The aim of this study is to evaluate in a Portuguese population the prognostic value of an updated CLTI classification based on Wound, Ischemia, and foot Infection (WIfI) proposed by the Society for Vascular Surgery. MATERIALS AND METHODS: Single-center retrospective evaluation of prospectively collected data of consecutive patients with CLTI submitted to lower limb revascularization from January to December of 2017...
February 9, 2024: Port J Card Thorac Vasc Surg
https://read.qxmd.com/read/38324006/effect-of-adding-virtual-reality-training-to-traditional-exercise-program-on-pain-mental-status-and-psychological-status-in-unilateral-traumatic-lower-limb-amputees-a-randomized-controlled-trial
#25
JOURNAL ARTICLE
Rami L Abbas, Didier Cooreman, Hala Al Sultan, Mayssah El Nayal, Ibtissam M Saab, Ayman El Khatib, Aseel El Kawam, Ahmed M El Melhat
Background: Lower limb amputation is an emotionally devastating condition that causes a complete change in the quality of life, may lead to phantom limb pain in most of the cases, and puts the individual in a high risk of developing psychological disorders. The objective of this study is to evaluate the consequence of adding virtual reality (VR) to a traditional exercise program on pain, mental status, and psychological status in traumatic unilateral lower limb amputees (LLAs). Methods: Thirty-two traumatic LLAs were randomly assigned into two equal groups in this randomized control trial...
February 6, 2024: Games for Health
https://read.qxmd.com/read/38324002/increase-in-streptococcal-necrotizing-fasciitis-during-and-after-the-coronavirus-disease-2019-pandemic
#26
JOURNAL ARTICLE
David Breidung, Moritz Billner, Ioannis-Fivos Megas, Alejandro Marti Edo, Bert Reichert, Asja T Malsagova
Background: Necrotizing fasciitis (NF) is a life-threatening and rare condition. However, we report and analyze a remarkably high number of NF cases during the coronavirus disease 2019 (COVID-19) pandemic and especially in the first months after the COVID-19 pandemic. Patients and Methods: We conducted a retrospective analysis of 17 cases of NF treated in our clinic between January and May 2023. Data were collected on demographics, comorbidities, risk factors, laboratory findings, and clinical outcomes. For each individual case two risk indicating scores, the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) and Laboratory and Anamnestic Risk Indicator for Necrotizing Fasciitis (LARINF) were calculated...
February 6, 2024: Surgical Infections
https://read.qxmd.com/read/38316811/predicting-outcomes-following-lower-extremity-open-revascularization-using-machine-learning
#27
JOURNAL ARTICLE
Ben Li, Raj Verma, Derek Beaton, Hani Tamim, Mohamad A Hussain, Jamal J Hoballah, Douglas S Lee, Duminda N Wijeysundera, Charles de Mestral, Muhammad Mamdani, Mohammed Al-Omran
Lower extremity open revascularization is a treatment option for peripheral artery disease that carries significant peri-operative risks; however, outcome prediction tools remain limited. Using machine learning (ML), we developed automated algorithms that predict 30-day outcomes following lower extremity open revascularization. The National Surgical Quality Improvement Program targeted vascular database was used to identify patients who underwent lower extremity open revascularization for chronic atherosclerotic disease between 2011 and 2021...
February 5, 2024: Scientific Reports
https://read.qxmd.com/read/38309426/association-between-statin-use-and-incident-pad-according-to-race-age-and-presence-of-depression-in-the-multi-ethnic-study-of-atherosclerosis-mesa
#28
JOURNAL ARTICLE
Demetria M Bolden, Adane F Wogu, Pamela N Peterson, Elsie G Ross, Shea E Hogan, Kunihiro Matsushita, Michael H Criqui, Matthew Allison
BACKGROUND: Peripheral artery disease (PAD) is associated with high morbidity and mortality and has been commonly described as a coronary heart disease equivalent. Statin medications are recommended for primary prevention of atherosclerotic cardiovascular disease (ASCVD) among other indications. Therefore, understanding the longitudinal relationship of incident PAD is necessary to inform future research on how to prevent disease. Depression complicates cardiovascular disease (CVD) patients' ability to properly adhere to their medications, yet the effect of depression on the relationship between statin use and incident PAD is understudied...
February 1, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38288696/risk-prediction-of-diabetic-foot-amputation-using-machine-learning-and-explainable-artificial-intelligence
#29
JOURNAL ARTICLE
Chien Wei Oei, Yam Meng Chan, Xiaojin Zhang, Kee Hao Leo, Enming Yong, Rhan Chaen Chong, Qiantai Hong, Li Zhang, Ying Pan, Glenn Wei Leong Tan, Malcolm Han Wen Mak
BACKGROUND: Diabetic foot ulcers (DFUs) are serious complications of diabetes which can lead to lower extremity amputations (LEAs). Risk prediction models can identify high-risk patients who can benefit from early intervention. Machine learning (ML) methods have shown promising utility in medical applications. Explainable modeling can help its integration and acceptance. This study aims to develop a risk prediction model using ML algorithms with explainability for LEA in DFU patients...
January 30, 2024: Journal of Diabetes Science and Technology
https://read.qxmd.com/read/38283407/lower-limb-preservation-in-pediatric-trauma-a-case-study-of-gustilo-grade-iiic-fracture-in-a-7-year-old
#30
Jamal Ataya, Rawan Daaboul, Hassan Alhomsi, Hassan Issa, Ahmad Elewee
This case report describes the intricate aspects of managing pediatric lower limb trauma. A 7-year-old patient had a severe compound fracture and significant soft tissue damage in the left lower limb, classified as Gustilo Grade IIIC. This necessitated the use of scoring systems such as the Mangled Extremity Severity Score and limb salvage index to assess the likelihood of limb preservation. Despite these high amputation risk indicators, a multidisciplinary approach has led to limb salvage surgery with internal fixation...
January 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38267238/multicentre-open-label-randomised-controlled-trial-to-compare-early-intervention-with-calcimimetics-and-conventional-therapy-in-preventing-coronary-artery-calcification-in-patients-with-secondary-hyperparathyroidism-upcoming-a-study-protocol
#31
JOURNAL ARTICLE
Daijo Inaguma, Yoshitaka Tatematsu, Naoki Okamoto, Soshiro Ogata, Hideki Kawai, Eiichi Watanabe, Yukio Yuzawa, Midori Hasegawa, Naotake Tsuboi
INTRODUCTION: Coronary artery and heart valve calcification is a risk factor for cardiovascular death in haemodialysis patients, so calcification prevention should be started as early as possible. Treatment with concomitant calcimimetics and low-dose vitamin D receptor activators (VDRAs) is available, but not enough evidence has been obtained on the efficacy of this regimen, particularly in patients with short dialysis duration. Therefore, this study will evaluate the efficacy and safety of early intervention with upacicalcet, a calcimimetic used to prevent coronary artery calcification in this patient population...
January 24, 2024: BMJ Open
https://read.qxmd.com/read/38266124/long-term-risk-prediction-after-major-lower-limb-amputation-1-year-results-of-the-perceive-study
#32
JOURNAL ARTICLE
Brenig Llwyd Gwilym, Philip Pallmann, Cherry-Ann Waldron, Emma Thomas-Jones, Sarah Milosevic, Lucy Brookes-Howell, Debbie Harris, Ian Massey, Jo Burton, Phillippa Stewart, Katie Samuel, Sian Jones, David Cox, Annie Clothier, Hayley Prout, Adrian Edwards, Christopher P Twine, David Charles Bosanquet
BACKGROUND: Decision-making when considering major lower limb amputation is complex and requires individualized outcome estimation. It is unknown how accurate healthcare professionals or relevant outcome prediction tools are at predicting outcomes at 1-year after major lower limb amputation. METHODS: An international, multicentre prospective observational study evaluating healthcare professional accuracy in predicting outcomes 1 year after major lower limb amputation and evaluation of relevant outcome prediction tools identified in a systematic search of the literature was undertaken...
January 3, 2024: BJS Open
https://read.qxmd.com/read/38264222/impact-of-diabetic-peripheral-neuropathy-on-gait-abnormalities-in-patients-with-type-2-diabetes-mellitus
#33
JOURNAL ARTICLE
Samir H Assaad Khalil, Hany Mohammed Ali El Deeb, Martin Otwang Dak Ajang, Nermin A Osman, Noha Gaber Amin
BACKGROUND: Many patients with type 2 diabetes (T2DM) suffer from diabetic peripheral neuropathy (DPN) and impaired muscle coordination. These changes may lead to walking instability, and gait abnormalities resulting in increased fall risk and lower limb amputations. The aim of this study was to assess the impact of DPN and patient footwear on the gait in patients with diabetes, in addition to Comparing the peak plantar pressure (PPP) in patients with and without DPN and assessing its association with gait abnormalities...
January 2024: Diabetology International
https://read.qxmd.com/read/38259160/what-is-the-revision-free-survival-of-resurfaced-allograft-prosthesis-composites-for-proximal-humerus-reconstruction-in-children-with-bone-tumors
#34
JOURNAL ARTICLE
Costantino Errani, Hisaki Aiba, Ahmed Atherley, Marco Palmas, Hiroaki Kimura, Davide Maria Donati, Marco Manfrini
BACKGROUND: Reconstruction of the proximal humerus in children who undergo bone tumor resection is challenging because of patients' small bone size and possible limb length discrepancy at the end of skeletal growth due to loss of the physis. There are several options for proximal humerus reconstruction in children, such as clavicula pro humero, free vascularized fibula grafting, massive bone osteoarticular allografting, endoprostheses, and allograft-prosthesis composites, but no consensus exists on the best method for reconstruction...
January 23, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38241452/developing-a-practical-tool-for-predicting-wound-healing-outcomes-of-patients-with-diabetic-forefoot-ulcers-focus-on-vasculopathy-and-infection
#35
JOURNAL ARTICLE
Kyung-Chul Moon, Ji-Hwan Cha, Seung-Kyu Han, Ji-Won Son
OBJECTIVE: To develop a preliminary risk scoring system to predict the prognosis of patients with diabetic forefoot ulcers based on the severity of vasculopathy and infection, which are the major risk factors for amputation. METHODS: Forefoot was defined as the distal part of the foot composed of the metatarsal bones and phalanges and associated soft tissue structures. The degree of vasculopathy was graded as V0, V1, or V2 according to transcutaneous partial oxygen tension values and toe pressure...
February 1, 2024: Advances in Skin & Wound Care
https://read.qxmd.com/read/38239532/foot-care-prioritization-among-health-care-providers-treating-diabetic-patients-in-saudi-arabia-a-survey-based-study
#36
JOURNAL ARTICLE
Rayan A Qutob, Osamah A Hakami, Layan Aldosari, Mohammad Alharfi, Raghad Y Alnader, Abdulaziz Alomar, Abdullah Alaryni, Abdullah Alghamdi, Eysa Alsolamy, Khalid Al Harbi, Yousef Alammari, Abdulwahed Abdulaziz Alotay, Mohammad A Alhajery, Abdulrahman Alanazi
BACKGROUND: Diabetic foot disease (DFD) is a significant complication associated with diabetes, characterized by the potential for progressive amputation of specific foot segments or the entire lower limb in the absence of timely identification of infection and intervention. The aim of our research is to evaluate the degree of importance given to foot care by healthcare professionals who are responsible for treating individuals with diabetes in Riyadh, Saudi Arabia. METHODS: This cross-sectional study utilized an online survey previously validated in Australia...
December 2023: Curēus
https://read.qxmd.com/read/38163037/pain-balance-confidence-functional-mobility-and-reach-are-associated-with-risk-of-recurrent-falls-among-adults-with-lower-limb-amputation
#37
JOURNAL ARTICLE
Mayank Seth, John Robert Horne, Ryan Todd Pohlig, Jaclyn Megan Sions
OBJECTIVE: The study evaluated whether pain intensity and extent, balance-confidence, functional mobility, and balance (eg, functional reach) are potential risk factors for recurrent falls among adults with a lower-limb amputation. DESIGN: Cross-sectional study. SETTING: Research laboratory. PARTICIPANTS: Eighty-three adults with unilateral lower-limb amputation that occurred >1 year prior (26 transfemoral- and 57 transtibial-level amputation; 44...
December 2023: Archives of rehabilitation research and clinical translation
https://read.qxmd.com/read/38160936/risk-prediction-scores-for-type-2-diabetes-microvascular-and-cardiovascular-complications-derived-and-validated-with-real-world-data-from-two-provinces-the-diabetes-complications-disco-risk-scores
#38
JOURNAL ARTICLE
Baiju R Shah, Peter C Austin, Noah M Ivers, Alan Katz, Alexander Singer, Monica Sirski, Deva Thiruchelvam, Karen Tu
OBJECTIVE: Existing tools to predict the risk of complications among people with type 2 diabetes poorly discriminate high- from low-risk patients. The objective of this study was to develop risk prediction scores for major type 2 diabetes complications using real-world clinical care data, and to externally validate these risk scores in a different jurisdiction. METHODS: Using healthcare administrative data and electronic medical records data, risk scores were derived using data from 25,088 people with type 2 diabetes from the Canadian province of Ontario, followed between 2002 and 2017...
December 29, 2023: Canadian Journal of Diabetes
https://read.qxmd.com/read/38138871/use-of-autologous-bone-graft-with-bioactive-glass-as-a-bone-substitute-in-the-treatment-of-large-sized-bone-defects-of-the-femur-and-tibia
#39
JOURNAL ARTICLE
Sebastian Findeisen, Niklas Gräfe, Melanie Schwilk, Thomas Ferbert, Lars Helbig, Patrick Haubruck, Gerhard Schmidmaier, Michael Tanner
BACKGROUND: Managing bone defects in non-union surgery remains challenging, especially in cases of large defects exceeding 5 cm in size. Historically, amputation and compound osteosynthesis with a remaining PMMA spacer have been viable and commonly used options. The risk of non-union after fractures varies between 2% and 30% and is dependent on various factors. Autologous bone grafts from the iliac crest are still considered the gold standard but are limited in availability, prompting consideration of artificial grafts...
November 24, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/38129301/-construction-and-preliminary-validation-of-a-risk-prediction-model-for-the-recurrence-of-diabetic-foot-ulcer-in-diabetic-patients
#40
JOURNAL ARTICLE
Q J Guo, J Ouyang, J Q Rao, Y Z Zhang, L L Yu, W Y Xu, J H Long, X H Gao, X Y Wu, Y Gu
Objective: To develop a risk prediction model for the recurrence of diabetic foot ulcer (DFU) in diabetic patients and primarily validate its predictive value. Methods: Meta-analysis combined with retrospective cohort study was conducted. The Chinese and English papers on risk factors related to DFU recurrence publicly published in China Biology Medicine disc, China National Knowledge Infrastructure, Wanfang Database, VIP Database, and PubMed, Embase, Cochrane Library, and Web of Science, and the search time was from the establishment date of each database until March 31st , 2022...
December 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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