Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Kylie Swiekatowski, Arvind Manisundaram, Delani Woods, Jackson C Green, Mohin A Bhadkamkar, Yuewei Wu-Fienberg
BACKGROUND: Blood transfusions have been associated with surgical complications; however, these studies are not specific to lower extremity (LE) reconstruction. We evaluated the effect of perioperative packed red blood cell (PRBC) transfusions on LE free flap outcomes in trauma patients. METHODS: Patients undergoing LE free flap reconstruction following acute injuries from 2016-2021 were retrospectively analyzed. The perioperative period for transfusions was defined as ±3 days from the procedure...
January 30, 2024: Journal of Reconstructive Microsurgery
#22
JOURNAL ARTICLE
Mar Muñoz-Chápuli Gutiérrez, Ainoa Sáez Prat, Ana Durán Vila, Mireia Bernal Claverol, Pilar Payá Martínez, Pilar Pintado Recarte, Mamen Viñuela Benéitez, Cristina Ausín García, Eva Cervilla Muñoz, Marisa Navarro, Pablo González Navarro, Melchor Álvarez-Mon, Miguel A Ortega, Juan de León-Luís
BACKGROUND: Post-COVID-19 condition has recently been defined as new or persistent common COVID-19 symptoms occurring three months after disease onset. The pathology of the disease is unclear, but immune and vascular factors seem to play a significant role. The incidence, severity, and implications of the disease after COVID-19 infection in pregnancy have not been established. We aimed to study the incidence and main risk factors for post-COVID-19 condition in an obstetric population and their implications for maternal and perinatal morbimortality...
January 2024: EClinicalMedicine
#23
JOURNAL ARTICLE
Adverse Events After Isolated Posterior Cruciate Ligament Reconstruction: A National Database Study.
Alexander J Kammien, Ryan C Price, William M McLaughlin, Nancy Park, Dustin L Richter, Robert C Schenck, Jonathan N Grauer, Michael J Medvecky
BACKGROUND: Optimal management after posterior cruciate ligament (PCL) injury remains an active area of research, as reconstruction is technically challenging and poses unique risks in the posterior knee. Studies have reported variable rates of complications. PURPOSE: To describe the rates of readmission, emergency department (ED) visits, and postoperative complications within 90 days of isolated PCL reconstruction (PCLR) in a large, national cohort to better understand the perioperative variables that influence a practitioner's decision of whether to pursue operative versus nonoperative management...
January 2024: Orthopaedic Journal of Sports Medicine
#24
JOURNAL ARTICLE
Elise Milosevich, Nele Demeyere, Sarah T Pendlebury
BACKGROUND: Infection and inflammation are dementia risk factors in population-based cohorts; however, studies in stroke are scarce. We determined the prevalence of infection after stroke and routinely measured inflammatory biomarkers during hospitalization and their associations with acute and 6-month cognitive impairment. METHODS AND RESULTS: A prospective stroke cohort completed the Oxford Cognitive Screen at ≤2 weeks and 6 months after stroke. Infection, inflammatory markers (C-reactive protein, white cell count, and neutrophil/lymphocyte ratio), and systemic inflammatory response syndrome were ascertained throughout admission with electronic patient records supplemented by hand searches...
January 12, 2024: Journal of the American Heart Association
#25
JOURNAL ARTICLE
Jianhao Li, Han Chen, Lang Bai, Hong Tang
BACKGROUND: HBV infection is the leading risk factor for HCC. HBV infection has been confirmed to be associated with the exhaustion status of CD8+ T cells and immunotherapeutic efficacy in HCC. In this study, we aimed to investigate the prognostic value of the CD8+ T-cell exhaustion signature and immunotherapy response in patients with HBV-related HCC. METHODS: We identified different clusters of HBV-related HCC cells by single-cell RNA sequencing (scRNA-seq) and identified CD8+ T-cell exhaustion-related genes (TERGs) by pseudotime analysis...
January 10, 2024: BMC Cancer
#26
JOURNAL ARTICLE
PCSK9 genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations.
Michael V Holmes, Christiana Kartsonaki, Ruth Boxall, Kuang Lin, Nicola Reeve, Canqing Yu, Jun Lv, Derrick A Bennett, Michael R Hill, Ling Yang, Yiping Chen, Huaidong Du, Iain Turnbull, Rory Collins, Robert J Clarke, Martin D Tobin, Liming Li, Iona Y Millwood, Zhengming Chen, Robin G Walters
AIM: Lowering low-density lipoprotein cholesterol (LDL-C) through PCSK9 inhibition represents a new therapeutic approach to preventing and treating cardiovascular disease (CVD). Phenome-wide analyses of PCSK9 genetic variants in large biobanks can help to identify unexpected effects of PCSK9 inhibition. METHODS: In the prospective China Kadoorie Biobank, we constructed a genetic score using three variants at the PCSK9 locus associated with directly-measured LDL-C (PCSK9-GS)...
January 10, 2024: European Journal of Preventive Cardiology
#27
JOURNAL ARTICLE
Isabelle D Ried, Hazem Omran, Max Potratz, Tanja K Rudolph, Smita Scholtz, Sabine Bleiziffer, Cornelia Piper
BACKGROUND AND AIMS: Prosthetic valve endocarditis (PVE) is the prognostically most unfavourable complication after aortic valve replacement. This study aims to contribute to a better understanding of the different pathological and therapeutical aspects between PVE following surgical (SAVR) and transcatheter aortic valve replacement (TAVI). METHODS: All patients who had undergone primary isolated SAVR (n = 3447) or TAVI (n = 2269) at our Centre between 01/2012 and 12/2018 were analysed...
January 3, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#28
REVIEW
Dan Li, Bei Pan, Ning Ma, Xiaoman Wang, Xiyuan Deng, Honghao Lai, Long Ge, Junqiang Niu, Kehu Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Lupus Nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE). However, the treatment of lupus nephritis using traditional Chinese medicine remains controversial. AIM OF THE STUDY: To assess the efficacy and safety of Shenqi Dihuang decoction in the treatment of LN and review the clinical guidelines. MATERIALS AND METHODS: Six databases (China National Knowledge Infrastructure, Wanfang, PubMed, China Biology Medicine, the Cochrane Library, and Embase) were searched from their inception to September 10, 2022, for randomized controlled trials on the treatment of lupus nephritis using Shenqi Dihuang decoction...
December 27, 2023: Journal of Ethnopharmacology
#29
JOURNAL ARTICLE
Q J Guo, J Ouyang, J Q Rao, Y Z Zhang, L L Yu, W Y Xu, J H Long, X H Gao, X Y Wu, Y Gu
Objective: To develop a risk prediction model for the recurrence of diabetic foot ulcer (DFU) in diabetic patients and primarily validate its predictive value. Methods: Meta-analysis combined with retrospective cohort study was conducted. The Chinese and English papers on risk factors related to DFU recurrence publicly published in China Biology Medicine disc, China National Knowledge Infrastructure, Wanfang Database, VIP Database, and PubMed, Embase, Cochrane Library, and Web of Science, and the search time was from the establishment date of each database until March 31st , 2022...
December 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
#30
JOURNAL ARTICLE
Robert She, Katsuhiro Kobayashi
PURPOSE: To compare the port infection rate between single-lumen and double-lumen ports and to determine if the use of a double-lumen port is an independent risk factor for port infection among cancer patients. MATERIALS AND METHODS: This retrospective study included 2,573 adult oncologic patients (age >18 years old) who had either a single-lumen (n=841) or a double-lumen (n=1,732) chest port implanted between 2013 and 2020 at a single institution. Patients who had port infection including port-site infection and port-related blood stream infection were identified through chart review...
December 19, 2023: Journal of Vascular and Interventional Radiology: JVIR
#31
REVIEW
Giovanna Chidini, Francesco Raimondi
In the realm of emergency medicine, the swift adoption of lung ultrasound (LU) has extended from the adult population to encompass pediatric and neonatal intensivists. LU stands out as a bedside, replicable, and cost-effective modality, distinct in its avoidance of ionizing radiations, a departure from conventional chest radiography. Recent years have witnessed a seamless adaptation of experiences gained in the adult setting to the neonatal and pediatric contexts, underscoring the versatility of bedside Point of care ultrasound (POCUS)...
March 2024: European Journal of Pediatrics
#32
JOURNAL ARTICLE
Shannon M McDonnell, Shaya Nikfar, Matthew Blecha, Pegge M Halandras
OBJECTIVES: Choosing the right hemodialysis vascular access for frail patients remains difficult as the patient's preferences and the likelihood of access function and survival must be considered. We hypothesize that patients identified prior to arteriovenous (AV) access as frail by the PRISMA-7 score may have worse outcomes, indicating that fistula creation may not be the most clinically beneficial option and it would be in the best interest of the patient to receive either AV graft placement or dialysis through a percutaneous catheter...
December 15, 2023: Journal of Vascular Surgery
#33
JOURNAL ARTICLE
Mosadoluwa Afolabi, Stephen S Johnston, Pranjal Tewari, Walter A Danker
PURPOSE: Disruptive bleeding can complicate surgical procedures, increasing resource use, and impacting patients' well-being. This study aims to elucidate the impact of comorbidity on the risk of disruptive surgical-related bleeding and selected transfusion-associated complications, as well as the incremental cost of such bleeding. PATIENTS AND METHODS: This retrospective analysis of the Premier Healthcare Database included patients who were age ≥18 years and who had a procedure of interest between 1-Jan-2019-31-Dec-2019: cholecystectomy, coronary artery bypass grafting, cystectomy, hepatectomy, hysterectomy, pancreatectomy, peripheral vascular, thoracic, and valve procedures (first=index)...
2023: Medical Devices: Evidence and Research
#34
JOURNAL ARTICLE
Vojtěch Peřina, Roman Šmucler, Petr Němec, Vladislav Barták
BACKGROUND: The focal infection theory has been used to explain several chronic systemic diseases in the past. Systemic diseases were thought to be caused by focal infections, such as caries and periodontal diseases, and dentists were held responsible for these diseases due to the spread of oral infections. As knowledge of the interrelationship between oral microorganisms and the host immune response has evolved over the last few decades, the focal infection theory has been modified in various ways...
December 2, 2023: International Dental Journal
#35
JOURNAL ARTICLE
Mohammad Hutaif, Abdullah Al Moaish, Mosleh Soliman, Anwar Al-Fadliy
BACKGROUND: Yemen has been experiencing a protracted civil war and humanitarian crisis since 2015, which has resulted in many war-related injuries. However, there is a lack of data on the epidemiology, characteristics, and outcomes of these injuries, especially the orthopedic ones. This study aimed to describe the war-related orthopedic injuries in Yemen and their impact on the patients' health and function. METHODS: This was a retrospective study based on medical records and trauma registries of 3930 patients who were admitted to three major trauma centers in Sana'a city with war-related orthopedic injuries from January 2015 to December 2020...
November 30, 2023: Conflict and Health
#36
JOURNAL ARTICLE
Maria Lukasik, Magdalena Telec, Radoslaw Kazmierski, Izabela Wojtasz, Natalia Andrzejewska-Gorczyńska, Wojciech Kociemba, Grzegorz Dworacki, Wojciech P Kozubski, Magdalena Frydrychowicz
BACKGROUND: Regulatory T cells (Tregs) are involved in the systemic immune response after ischemic stroke. However, their role remains unclear, and the effect appears to be both neuroprotective and detrimental. Treg suppressor function may result in immunodepression and promote stroke-associated infection (SAI). Thus we assume that the bidirectional effects of Tregs may be in part attributed to the intracellular transcription factor Helios. Tregs with Helios expression (H+ Tregs) constitute 70-90% of all Treg cells and more frequently than Helios-negative Tregs (H- Tregs) express molecules recognized as markers of Tregs with suppressor abilities...
November 23, 2023: Journal of Neuroinflammation
#37
JOURNAL ARTICLE
Ke Xu, Brenda Lin, Loreski Collado, Michelle C Martin, Sarah J Carlson, Joseph D Raffetto, James T McPhee
OBJECTIVE: The aim of this study was to create a simple risk score to identify factors associated with wound complications after infrainguinal revascularization. METHOD: The Veterans Affairs Surgical Quality Improvement Program national data set was queried from 2005 to 2021 to identify 22,114 patients undergoing elective open revascularization for peripheral arterial disease (claudication, rest pain, tissue loss) or peripheral aneurysm. Emergency and trauma cases were excluded...
November 19, 2023: Journal of Vascular Surgery
#38
JOURNAL ARTICLE
Perla Rocío Colunga-Pedraza, Luz María Barbosa Castillo, Edgar Ulises Coronado Alejandro, Héctor Alejandro Vaquera-Alfaro, Ingrid Gabriela Lopez Reyna, Julia E Colunga-Pedraza, David Gómez Almaguer
BACKGROUND: Chronic graft-versus-host disease (cGvHD) is a major complication that puts patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) at risk of death or infection. Currently, there is no gold standard for the first-line treatment of patients who do not respond to steroids, and there are several therapeutic options being evaluated in clinical trials for this disease to be used even in the first-line treatment for GvHD. There is evidence of the benefit of rituximab, an anti-CD20 antibody, at a standard dose of 375 mg/m2 weekly in the treatment of steroid-refractory chronic graft-versus disease (SR-cGvHD)...
November 14, 2023: Transplant Immunology
#39
JOURNAL ARTICLE
Predictors of mortality in periprosthetic fractures of the hip: Results from the national PPF study.
Ahmed Abdul Hadi Harb Nasser, Rohan Prakash, Charles Handford, Khabab Osman, Govind Singh Chauhan, Rajpal Nandra, Ansar Mahmood, Varun Dewan, Jerome Davidson, Mohammed Al-Azzawi, Christian Smith, Mothana Gawad, Ioannis Palaiologos, Rory Cuthbert, Warran Wignadasan, Daniel Banks, James Archer, Abdulrahman Odeh, Thomas Moores, Muaaz Tahir, Margaret Brooks, Gurdeep Biring, Stevan Jordan, Zain Elahi, Mohammed Shaath, Manoj Veettil, Chiranjit De, Charles Handford, Mohit Bansal, Akshdeep Bawa, Ahmed Mattar, Varun Tandra, Audrina Daadipour, Ahmed Taha, Shafat Gangoo, Sriram Srinivasan, Mandishona Tarisai, Basil Budair, Krishna Subbaraman, Farrukh Khan, Austin Gomindes, Arjun Samuel, Niel Kang, Karan Kapur, Elizabeth Mainwaring, Hannah Bridgwater, Andre Lo, Usman Ahmed, Tahir Khaleeq, Ahmed El-Bakoury, Ramy Rashed, Hazem Hosny, Rathan Yarlagadda, Jonathan Keenan, Ahmed Hamed, Bryan Riemer, Arham Qureshi, Vatsal Gupta, Matthew Waites, Sabri Bleibleh, David Westacott, Jonathan Phillips, Jamie East, Daniel Huntley, Saqib Masud, Yusuf Mirza, Sandeep Mishra, David Dunlop, Mohamed Khalefa, Balakumar Balasubramanian, Mahesh Thibbaiah, Olivia Payton, James Berstock, Krisna Deano, Khaled Sarraf, Kartik Logishetty, George Lee, Hariharan Subbiah-Ponniah, Nirav Shah, Aakaash Venkatesan, James Cheseldene-Culley, Joseph Ayathamattam, Samantha Tross, Sukhwinder Randhawa, Faisal Mohammed, Ramla Ali, Jonathan Bird, Kursheed Khan, Muhammad Adeel Akhtar, Andrew Brunt, Panagiotis Roupakiotis, Padmanabhan Subramanian, Nelson Bua, Mounir Hakimi, Samer Bitar, Majed Al Najjar, Ajay Radhakrishnan, Charlie Gamble, Andrew James, Catherine Gilmore, Dan Dawson, Rajesh Sofat, Mohamed Antar, Aashish Raghu, Sam Heaton, Waleed Tawfeek, Christerlyn Charles, Henry Burnand, Sean Duffy, Luke Taylor, Laura Magill, Rita Perry, Michala Pettitt, Kelvin Okoth, Thomas Pinkney
INTRODUCTION: Periprosthetic fractures (PPFs) around the hip joint are increasing in prevalence. In this collaborative study, we aimed to investigate the impact of patient demographics, fracture characteristics, and modes of management on in-hospital mortality of PPFs involving the hip. METHODS: Using a multi-centre cohort study design, we retrospectively identified adults presenting with a PPF around the hip over a 10-year period. Univariate and multivariable logistic regression analyses were performed to study the independent correlation between patient, fracture, and treatment factors on mortality...
December 2023: Injury
#40
JOURNAL ARTICLE
Adam Beucler, Elias Wheibe, Sagar S Gandhi, Joseph Vv Blas, Christopher G Carsten, Bruce H Gray
BACKGROUND: Critical limb threatening ischemia (CLTI), particularly in patients with ischemic ulceration has been associated with significant morbidity and mortality. Typically, endovascular therapy has been first-line therapy for our patients, but this strategy has come into question based upon the Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Threatening Ischemia (BEST-CLI) trial data. METHODS AND RESULTS: For comparative purposes, we evaluated outcomes from 150 CLTI patients with ischemic ulceration treated with endovascular-first therapy...
February 2024: Annals of Vascular Surgery
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
