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https://www.readbyqxmd.com/read/29907667/symptoms-of-autonomic-dysfunction-in-systemic-sclerosis-assessed-by-the-compass-31-questionnaire
#1
Brittany L Adler, James W Russell, Laura K Hummers, Zsuzsanna H McMahan
OBJECTIVE: Autonomic dysfunction is a known complication of systemic sclerosis (SSc) that can affect vascular tone, gastrointestinal (GI) motility, heart rate, and blood pressure control. We sought to quantify autonomic symptom burden in SSc, and to define the characteristics of patients with SSc and autonomic dysfunction. METHODS: Patients with SSc were consecutively recruited during routine clinical visits at the Johns Hopkins Scleroderma Center and asked to complete the Composite Autonomic Symptom Score (COMPASS)-31 questionnaire, a validated tool to assess symptoms of autonomic dysfunction...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907575/current-evidence-for-anesthesia-management-during-endovascular-stroke-therapy-updated-systematic-review-and-meta-analysis
#2
Nitin Goyal, Konark Malhotra, Muhammad F Ishfaq, Georgios Tsivgoulis, Christopher Nickele, Daniel Hoit, Adam S Arthur, Andrei V Alexandrov, Lucas Elijovich
INTRODUCTION: Debate continues about the optimal anesthetic management for patients undergoing endovascular treatment (ET) of acute ischemic stroke due to emergent large vessel occlusion. OBJECTIVE: To compare, using current evidence, the clinical outcomes and procedural characteristics among patients undergoing general anesthesia (GA) and local or monitored anesthesia (non-GA). METHODS: We performed a systematic review and meta-analysis of all available studies that involved the use of stent retrievers for ET (stentriever group)...
June 15, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29904431/interventions-and-mechanisms-of-n-acetylcysteine-on-monocrotaline-induced-pulmonary-arterial-hypertension
#3
Wencheng Yu, Xiaoxia Song, Chen Lin, Weina Ji
The aim of the present study was to investigate the impact of N-acetylcysteine (NAC) on the expression of activin receptor-like kinase-1 (ALK-1) and mothers against decapentaplegic homolog 1 (Smad1) in the pulmonary artery of rats with pulmonary arterial hypertension (PAH), and to explore the possible mechanisms underlying its effects on pulmonary vascular remodeling (PVR). In total, 32 Wistar rats were randomly divided into four groups: Control, model, low-dose (100 mg/kg/day) NAC and high-dose (500 mg/kg/day) NAC...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29903892/novel-association-of-germline-de-novo-myh9-mutation-with-congenital-hemangioma
#4
Elena I Fomchenko, Daniel Duran, Sheng Chih Jin, Weilai Dong, E Zeynep Erson-Omay, Prince Antwi, August Allocco, Jonathan R Gaillard, Anita Huttner, Murat Gunel, Michael L DiLuna, Kristopher T Kahle
Congenital hemangiomas are tumor-like vascular malformations with poorly understood pathogenesis. We report the case of a neonate with a massive congenital scalp hemangioma that required urgent neurosurgical removal on the second day of life due to concern for high-flow arteriovenous shunting. Exome sequencing identified a rare damaging de novo germline mutation in MYH9 (c.5308C>T, p.[Arg1770Cys]), encoding the MYH9 non-muscle myosin IIA. MYH9 has a probability of loss-of-function intolerance (pLI) score > 0...
June 14, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29902977/conbercept-for-patients-with-age-related-macular-degeneration-a-systematic-review
#5
Jiaxing Zhang, Yi Liang, Juan Xie, Dong Li, Qian Hu, Xiaosi Li, Wenyi Zheng, Rui He
BACKGROUND: Conbercept is a novel vascular endothelial growth factor (VEGF) inhibitor for the treatment of wet age-related macular degeneration (AMD). This systematic review aims to assess the efficacy and safety of conbercept in the treatment of wet AMD. METHODS: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP database, and Wanfang database were searched from their earliest records to June 2017. We included randomized controlled trials (RCTs) evaluating the efficacy and safety of conbercept in wet AMD patients...
June 15, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29902236/short-and-long-term-survival-after-open-versus-endovascular-repair-of-abdominal-aortic-aneurysm-polish-population-analysis
#6
Bartosz Symonides, Andrzej Śliwczyński, Zbigniew Gałązka, Jarosław Pinkas, Zbigniew Gaciong
OBJECTIVES: The aim of the study was to compare short and long-term mortality and readmissions in patients with non-ruptured abdominal aortic aneurysm (AAA) treated with endovascular aortic repair (EVAR) or open aneurysm repair (OAR). DESIGN: Retrospective survival analysis based on prospectively collected medical records of the national Polish public health insurer. MATERIALS: In the National Health Fund database we identified all patients who underwent elective open or endovascular treatment of AAA between January 1st 2011 and March 22nd 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29901817/nicotine-treatment-ameliorates-dss-induced-colitis-by-suppressing-madcam-1-expression-and-leukocyte-recruitment
#7
Koji Maruta, Chikako Watanabe, Hideaki Hozumi, Chie Kurihara, Hirotaka Furuhashi, Takeshi Takajo, Yoshikiyo Okada, Kazuhiko Shirakabe, Masaaki Higashiyama, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Toshiaki Ishizuka, Soichiro Miura, Ryota Hokari
The enhanced recruitment of leukocytes to the inflamed colon is a key feature of ulcerative colitis (UC). The gut-specific adhesion molecules involved in leukocyte recruitment have emerged as recent therapeutic targets. Nicotine absorbed from smoking has been reported to work protectively in UC patients. Our hypothesis is that nicotine may suppress the aberrant leukocyte recruitment and colonic inflammation via the suppression of the overexpressed gut-specific adhesion molecules in the inflamed colon. To test this hypothesis, the severity of colitis and the degree of leukocyte recruitment induced by gut-specific adhesion molecules were assessed in dextran sulfate sodium (DSS) colitis mice (C57BL/6J mice treated with 3% DSS) with or without nicotine treatment...
June 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29901771/preparedness-evaluation-of-french-military-orthopedic-surgeons-before-deployment
#8
Camille Choufani, Olivier Barbier, Aurélie Mayet, Sylvain Rigal, Laurent Mathieu
Introduction: A deployed military orthopedic surgeon is a trauma surgeon working in austere conditions. The first aim of this study was to analyze the current activity of French military orthopedic surgeons in the field and to identify the differences of the combat zone with their daily practice. The second aim was to assess the adequacy of the preparedness they received before their deployment and to identify additional needs that could be addressed in future training. Methods: An evaluation survey was sent to all French military orthopedic surgeons deployed in theaters of operations between 2004 and 2014...
June 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29900411/the-effect-of-different-combinations-of-vascular-dependency-and-cognitive-endpoints-on-the-sample-size-required-to-detect-a-treatment-effect-in-trials-of-treatments-to-improve-outcome-after-lacunar-and-non-lacunar-ischaemic-stroke
#9
Stephen Dj Makin, Fergus N Doubal, Terence J Quinn, Philip Mw Bath, Martin S Dennis, Joanna M Wardlaw
Background: Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endpoints. Methods: We prospectively recruited patients with lacunar and minor non-lacunar ischaemic stroke (NIHSS ≤ 7) and assessed recurrent vascular events (stroke, transient ischaemic attack (TIA), ischemic heart disease (IHD)), modified Rankin Score (mRS) and cognitive testing with the Addenbrooke's Cognitive Examination (ACE-R) one year post-stroke...
March 2018: European stroke journal
https://www.readbyqxmd.com/read/29900410/prediction-models-for-clinical-outcome-after-a-carotid-revascularisation-procedure-a-systematic-review
#10
Eline J Volkers, Ale Algra, L Jaap Kappelle, Jacoba P Greving
Introduction: Prediction models for clinical outcome after carotid artery stenting or carotid endarterectomy could aid physicians in estimating peri- and postprocedural risks in individual patients. We aimed to identify existing prediction models for short- and long-term outcome after carotid artery stenting or carotid endarterectomy in patients with symptomatic or asymptomatic carotid stenosis, and to summarise their most important predictors and predictive performance. Patients and methods: We performed a systematic literature search for studies that developed a prediction model or risk score published until 22 December 2016...
March 2018: European stroke journal
https://www.readbyqxmd.com/read/29900170/the-stromal-vascular-fraction-from-fat-tissue-in-the-treatment-of-osteochondral-knee-defect-case-report
#11
Ramil Z Salikhov, Ruslan F Masgutov, Mikhail A Chekunov, Leysan G Tazetdinova, Galina Masgutova, Oleg V Teplov, Damir Galimov, Yuri Plakseichuk, Ramil Yagudin, Igor O Pankov, Albert Rizvanov
In this study we applied autologous fat tissue stromal vascular fraction (SVF) cells in combination with microfracturing technique in a 36-year-old man with an osteochondral lesion of the medial femoral condyle 8 months after the injury. Cell material was generated by fat tissue liposuction from the anterior abdominal wall with subsequent extraction of the SVF and injected through a mini-arthrotomy portal with subsequent fibrin sealant fixation. The follow-up period was 2 years. Clinical score improved from 23 to 96 according to IKDC and from 10 to 90 according to EQ-VAS at 24 months follow-up...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29898969/increased-caide-dementia-risk-cognition-csf-biomarkers-and-vascular-burden-in-healthy-adults
#12
Mirian Ecay-Torres, Ainara Estanga, Mikel Tainta, Andrea Izagirre, Maite Garcia-Sebastian, Jorge Villanua, Montserrat Clerigue, Ane Iriondo, Iratxe Urreta, Arantzazu Arrospide, Carmen Díaz-Mardomingo, Miia Kivipelto, Pablo Martinez-Lage
OBJECTIVE: To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. METHOD: Cognitively normal participants (mean age 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR; n = 82) or low risk (LR; n = 293) for dementia according to a CAIDE score cutoff of 9...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29897969/gene-expression-analysis-of-nidus-of-cerebral-arteriovenous-malformations-reveals-vascular-structures-with-deficient-differentiation-and-maturation
#13
Jaya Mary Thomas, Sumi Surendran, Mathew Abraham, Dhakshmi Sasankan, Sridutt Bhaadri, Arumugam Rajavelu, Chandrasekharan C Kartha
OBJECTIVE: Arteriovenous malformations (AVMs) are characterised by tangles of dysplastic blood vessels which shunt blood from arteries to veins with no intervening capillary bed. It is not known at what stage of development and differentiation, AVM vessels became aberrant. To address this, we have analysed the expression of vascular differentiation, vascular maturation and brain capillary specific genes in AVM nidus. METHODOLOGY: We performed immunohistochemistry and western blot analysis of vascular differentiation (HEY2, DLL4, EFNB2, and COUP-TFII), vascular maturation (ENG and KLF2) and brain capillary specific genes (GGTP and GLUT1) on ten surgically excised human brain AVMs and ten normal human brain tissues...
2018: PloS One
https://www.readbyqxmd.com/read/29897296/high-iliac-calcium-score-is-associated-with-increased-severity-and-complexity-of-peripheral-arterial-disease-and-predicts-global-atherosclerotic-burden
#14
Zsuzsanna Jeremias, Nora Rat, Imre Benedek, Emese Rapolti, Mihaela Ratiu, Adrian Muresan, Theodora Benedek
BACKGROUND: The role of vascular calcifications in iliac arteries for predicting global atherosclerotic burden in still unknown. The aim of this study was to investigate whether iliac calcium score (ICS), a new computed tomographic angiography (CTA) derived biomarker of vascular calcification, can predict the severity and complexity of peripheral arterial disease (PAD) as well as the global atherosclerotic burden. PATIENTS AND METHODS: This was a single centre, non-randomized, observational prospective study on 84 consecutive patients with symptomatic peripheral arterial disease, undergoing peripheral CTA examination of the lower limbs, divided into high (n = 42) and low ICS (n = 42) groups with a median value for ICS of 3934 HU...
June 13, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29895489/shengui-sansheng-san-extraction-is-an-angiogenic-switch-via-regulations-of-akt-mtor-erk1-2-and-notch1-signal-pathways-after-ischemic-stroke
#15
Bowen Liu, Cheng Luo, Zhaoguang Zheng, Zhenyan Xia, Qian Zhang, Chienchih Ke, Renshyan Liu, Yonghua Zhao
BACKGROUND: As a traditional Chinese herbal formula, Shengui Sansheng San (SSS) has been employed for stroke treatment more than 300 years. PURPOSE: We hypothesize that SSS extraction is an angiogenic switch in penumbra post-stroke, and corresponding mechanisms are investigated. METHODS: In present study, rats were subjected to permanent middle cerebral artery occlusion model (MCAo) and were treated with low, middle and high doses of SSS extraction...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29893827/prediction-of-electro-anatomical-substrate-using-apple-score-and-biomarkers
#16
Jelena Kornej, Petra Büttner, Philipp Sommer, Nikolaos Dagres, Borislav Dinov, Katja Schumacher, Andreas Bollmann, Gerhard Hindricks
Aims: Low voltage areas (LVAs) represent advanced remodelling processes in left atrium in patients with atrial fibrillation (AF) and are associated with higher rates of arrhythmia recurrences. However, the prediction of LVA based on clinical parameters is understudied. Recently, we introduced APPLE score to predict rhythm outcomes after catheter ablation. The aim of this study was to analyse (i) LVA prediction using APPLE score and (ii) differences in biomarker profiles according to APPLE score in AF patients...
June 8, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29893650/hippocampal-calcifications-risk-factors-and-association-with-cognitive-function
#17
Esther J M de Brouwer, Remko Kockelkoren, Jules J Claus, Annemarieke de Jonghe, Mirjam I Geerlings, Thomas E F Jongsma, Willem P T M Mali, Jeroen Hendrikse, Pim A de Jong, Huiberdina L Koek
Purpose To identify risk factors for hippocampal calcifications and to investigate the association between hippocampal calcifications and cognitive function. Materials and Methods For this retrospective study, consecutive patients visiting a memory clinic at a Dutch general hospital between April 2009 and April 2015 were identified. All individuals underwent a standard diagnostic work-up including cognitive tests and brain CT. The following vascular risk factors were assessed: hypertension, diabetes mellitus, hyperlipidemia, and smoking...
June 12, 2018: Radiology
https://www.readbyqxmd.com/read/29893364/audiovisual-sexual-stimulation-and-rigiscan-test-for-the-diagnosis-of-erectile-dysfunction
#18
Tao Wang, Li Zhuan, Zhuo Liu, Ming-Chao Li, Jun Yang, Shao-Gang Wang, Ji-Hong Liu, Qing Ling, Wei-Min Yang, Zhang-Qun Ye
Background: Currently available evaluation criteria for penile tumescence and rigidity have been fraught with controversy. In this study, we sought to establish normative Chinese evaluation criteria for penile tumescence and rigidity by utilizing audiovisual sexual stimulation and RigiScan™ test (AVSS-Rigiscan test) with the administration of phosphodiesterase-5 inhibitor. Methods: A total of 1169 patients (aged 18-67 years) complained of erectile dysfunction (ED) underwent AVSS-RigiScan test with the administration of phosphodiesterase-5 inhibitor...
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29893297/18f-fluorodeoxyglucose-positron-emission-tomography-based-evaluation-of-systemic-and-vascular-inflammation-and-assessment-of-the-effect-of-systemic-treatment-on-inflammation-in-patients-with-moderate-to-severe-psoriasis-a-randomized-placebo-controlled-pilot
#19
Sharonjeet Kaur, Nusrat Shafiq, Sunil Dogra, B R Mittal, Savita Verma Attri, Ajay Bahl, Tarun Narang, Keshavamurthy Vinay, Sujit Rajagopalan, Samir Malhotra
Background: Psoriasis is a systemic inflammatory disorder associated with an increased risk of cardiovascular disease. Objective: To evaluate the utility of [18 F]-fluorodeoxyglucose positron emission tomography/computed tomography in identifying vascular and systemic inflammation in psoriasis patients with moderate-to-severe disease and to analyze its usefulness in assessing the effect of systemic treatment. Methods: This was a randomized, double-blind pilot study conducted in a tertiary care center...
June 8, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29893031/human-primary-cd34-cells-transplantation-for-critical-limb-ischemia
#20
Weishuai Lian, Xiaoxiao Hu, Long Pan, Shilong Han, Chuanwu Cao, Zhongzhi Jia, Maoquan Li
BACKGROUND: The goal of this study was to characterize the properties of human CD34+ cells in culture and investigate the feasibility and efficacy of CD34+ transplantation in a mouse model of limb ischemia and in patients with no-option critical limb ischemia. METHODS: Human CD34+ cells isolated from peripheral blood and grown in culture for up to four passages stained positively for the surface markers CD34 and CD133 and showed high viability after cryopreservation and recovery...
June 11, 2018: Journal of Clinical Laboratory Analysis
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