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Marcel Henrique Marcondes Sari, Ana Cristina Guerra Souza, Suzan Gonçalves Rosa, Diego Souza, Oscar Endrigo Dorneles Rodrigues, Cristina Wayne Nogueira
This study investigated the antinociceptive action of p-chloro-selenosteroid (PCS), administered by intragastric route (i.g.) to mice against acute models. The contribution of adenosinergic, dopaminergic, serotonergic, nitric oxide and opioid systems was investigated. It was evaluated if the administration of PCS triggers toxic effect. Treatment with PCS (10mg/kg) reduced writhing induced by acetic acid and its effect lasts up to 48 h after treatment. The compound caused an inhibition in neurogenic and inflammatory phases of nociception and in paw edema induced by formalin...
February 15, 2014: European Journal of Pharmacology
Cristiano R Jesse, Ethel A Wilhelm, Cristiani F Bortolatto, Cristina W Nogueira
The present study investigated a possible antidepressant-like activity of bis selenide using two predictive tests for antidepressant effect on rodents: the forced swimming test (FST) and the tail suspension test (TST). Bis selenide (0.5-5 mg/kg, p.o.) decreased the immobility time in the mouse FST and TST. The anti-immobility effect of bis selenide (1 mg/kg, p.o.) in the TST was prevented by the pretreatment of mice with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, i.p., an inhibitor of serotonin synthesis), ketanserin (1 mg/kg, i...
March 17, 2010: Progress in Neuro-psychopharmacology & Biological Psychiatry
Lucielli Savegnago, Cristiano R Jesse, Larissa G Pinto, Joao B T Rocha, Cristina W Nogueira, Gilson Zeni
In this study, the antidepressant-like effect caused by diphenyl diselenide on rat forced swimming test (FST) was investigated. The involvement of the monoaminergic system in the antidepressant-like effect was also evaluated. Diphenyl diselenide (0.1-30 mg/kg), given by oral route (p.o.), 30 min earlier, reduced the immobility time in the FST, without accompanying changes in ambulation when assessed in an open field. The anti-immobility effect of diphenyl diselenide (1 mg/kg, p.o.) on the FST was prevented by pretreatment of rats with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, i...
August 15, 2007: Progress in Neuro-psychopharmacology & Biological Psychiatry
V Gebbia, G Cannata, A Testa, G Curto, R Valenza, C Cipolla, M A Latteri, N Gebbia
BACKGROUND: A single-institution, prospective, randomized open trial was performed to compare ondansetron and granisetron in the prevention of chemotherapy-related nausea and vomiting. The effect of antemetic drugs was analyzed indipendently for patients treated with highly emetogenic chemotherapy (Study 1), and those treated with moderately emetogenic regimens (Study 2). METHODS: In Study 1, 182 patients treated with chemotherapeutic regimens containing high dose cisplatin (more than 70 mg/m2) were randomized to receive 24 mg of ondasentron intravenously (i...
October 1, 1994: Cancer
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