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https://www.readbyqxmd.com/read/29181857/whole-exome-sequencing-of-the-bdr-cohort-evidence-to-support-the-role-of-the-pilra-gene-in-alzheimer-s-disease
#1
Tulsi Patel, Keeley J Brookes, James Turton, Sultan Chaudhury, Tamar Guetta-Baranes, Rita Guerreiro, Jose Bras, Dena Hernandez, Andrew Singleton, Paul T Francis, John Hardy, Kevin Morgan
AIM: Late-onset Alzheimer's disease (LOAD) accounts for 95% of all Alzheimer's cases and is genetically complex in nature. Overlapping clinical and neuropathological features between AD, FTD and Parkinson's disease highlight the potential role of genetic pleiotropy across diseases. Recent GWAS have uncovered 20 new loci for AD risk, however these exhibit small effect sizes. Using NGS, here we perform association analyses using exome-wide and candidate-gene driven approaches. METHODS: Whole-exome sequencing was performed on 132 AD cases and 53 control samples...
November 27, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29158537/medicinal-plant-leaf-extract-and-pure-flavonoid-mediated-green-synthesis-of-silver-nanoparticles-and-their-enhanced-antibacterial-property
#2
Siddhant Jain, Mohan Singh Mehata
The rewards of using plants and plant metabolites over other biological methods for nanoparticle synthesis have fascinated researchers to investigate mechanisms of metal ions uptake and bio-reduction by plants. Here, green chemistry were employed for the synthesis of silver nanoparticles (AgNPs) using leaf extracts of Ocimum Sanctum (Tulsi) and its derivative quercetin (flavonoid present in Tulsi) separately as precursors to investigate the role of biomolecules present in Tulsi in the formation of AgNPs from cationic silver under different physicochemical conditions such as pH, temperature, reaction time and reactants concentration...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29123996/herbal-combat-against-e-faecalis-an-in-vitro-study
#3
Shipra Jaidka, Rani Somani, Deepti Jawa Singh, Tasneem Sheikh, Nidhi Chaudhary, Asiya Basheer
Background: Herbs have renewed importance in this modern era for their antimicrobial properties and fewer side effects. So a novel idea to use these herbs for pulpectomy; was implemented. There are chances of failure of pulpectomy due to inefficient removal of microbial load. Thus, for a successful endodontic treatment, obturating material with optimum antimicrobial properties is advocated in the present study. Aim: To compare and evaluate the antibacterial efficacy of zinc oxide eugenol, zinc oxide with tulsi extract and zinc oxide with aloe vera as obturating materials against E...
September 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29104390/an-in-vitro-comparative-evaluation-of-efficacy-of-disinfecting-ability-of-garlic-oil-neem-oil-clove-oil-and-tulsi-oil-with-autoclaving-on-endodontic-k-files-tested-against-enterococcus-faecalis
#4
Shivayogi Hugar, Punit M Patel, Jyoti Nagmoti, Chaitanya Uppin, Laresh Mistry, Neha Dhariwal
Aim: To comparatively evaluate the efficacy of disinfecting ability of garlic oil, neem oil, clove oil, and tulsi oil with autoclaving on endodontic K files tested against Enterococcus faecalis. Materials and methods: Fifty endodontic K files were exposed to the test micro-organism and checked for its disinfecting ability using three different methods. Result: Garlic oil, clove oil, tulsi oil and autoclave showed considerable effectiveness against E...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29103623/polygenic-risk-score-in-postmortem-diagnosed-sporadic-early-onset-alzheimer-s-disease
#5
Sultan Chaudhury, Tulsi Patel, Imelda S Barber, Tamar Guetta-Baranes, Keeley J Brookes, Sally Chappell, James Turton, Rita Guerreiro, Jose Bras, Dena Hernandez, Andrew Singleton, John Hardy, David Mann, Kevin Morgan
Sporadic early-onset Alzheimer's disease (sEOAD) exhibits the symptoms of late-onset Alzheimer's disease but lacks the familial aspect of the early-onset familial form. The genetics of Alzheimer's disease (AD) identifies APOEε4 to be the greatest risk factor; however, it is a complex disease involving both environmental risk factors and multiple genetic loci. Polygenic risk scores (PRSs) accumulate the total risk of a phenotype in an individual based on variants present in their genome. We determined whether sEOAD cases had a higher PRS compared to controls...
October 10, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29062181/micronutrients-drift-during-daily-and-weekly-iron-supplementation-in-non-anaemic-and-anaemic-pregnancy
#6
Hari Shankar, Neeta Kumar, Rajat Sandhir, Suneeta Mittal, Tulsi Adhikari, Arun Kumar, D N Rao
AIMS: Pregnancy is a phenomenon associated with dynamic changes in physical, mental and biochemical status of body and demands increased nutritional intake for developing foetus. The level of various micronutrients which act as co-factors for antioxidant enzymes or it-self as antioxidants gets altered with the progression of pregnancy. The present longitudinal study summarized the trend of selected micronutrients level in anaemic (AP) and non-anaemic primigravida (NAP) supplemented with daily and weekly oral iron folic acid (IFA) tablet during pregnancy and postpartum...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28958512/physicochemical-and-viscoelastic-properties-of-honey-from-medicinal-plants
#7
Huong Thi Lan Nguyen, Naksit Panyoyai, Vilia Darma Paramita, Nitin Mantri, Stefan Kasapis
The present work investigated the physicochemical and structural properties of Tulsi, Alfalfa and two varieties of Manuka honey derived from medicinal plants. Chemical analysis yielded data on the content of reducing sugars (glucose and fructose) that dominate the honey matrix, and of the minor constituents of protein, phenols and flavonoids. Standard chemical assays were used to develop a database of water content, electrical conductivity, pH, ash content, visual appearance and colour intensity. Physicochemical characteristics were related to structural behaviour of the four honey types, as recorded by small-deformation dynamic oscillation in shear, micro- and modulated differential scanning calorimetry, wide angle X-ray diffraction and infrared spectroscopy...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28867572/pharmacokinetic-and-pharmacodynamic-interaction-of-hydroalcoholic-extract-of-ocimum-sanctum-with-valproate
#8
Sudhir Chandra Sarangi, Dipesh Joshi, Ritesh Kumar, Thomas Kaleekal, Yogendra Kumar Gupta
For effective control of seizures, antiepileptic drugs (AEDs) are administered at higher dose which is associated with several adverse effects. This study envisaged antiepileptic and neuroprotective potential of Tulsi, a commonly used herb for its immunomodulatory property. The optimal dose of Ocimum sanctum hydroalcoholic extract (OSHE) was determined using maximal electroshock seizure (MES)- and pentylenetetrazol (PTZ)-induced seizure models in Wistar rats (200-250g) after administering OSHE (200-1000mg/kg) orally for 14days...
August 31, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28811698/effect-of-tulsi-ocimum-sanctum-linn-supplementation-on-metabolic-parameters-and-liver-enzymes-in-young-overweight-and-obese-subjects
#9
Swayamjeet Satapathy, Namrata Das, Debapriya Bandyopadhyay, Sushil Chandra Mahapatra, Dip Sundar Sahu, Mruthyumjayarao Meda
Ocimum sanctum Linn. (also known as Tulsi) is a sacred Indian plant, the beneficial role of which, in obesity and diabetes is described traditionally. This is a randomized, parallel group, open label pilot study to investigate the effect of O. sanctum on metabolic and biochemical parameters in thirty overweight/obese subjects, divided into two groups A and B. Group A (n = 16) received one 250 mg capsule of Tulsi (O. sanctum) extract twice daily in empty stomach for 8 weeks and group B (n = 14) received no intervention...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28771579/safe-delivery-care-practices-in-western-nepal-does-women-s-autonomy-influence-the-utilization-of-skilled-care-at-birth
#10
Tulsi Ram Bhandari, V Raman Kutty, P Sankara Sarma, Ganesh Dangal
Despite various efforts to increase the utilization of skilled birth attendants (SBA), nearly two-thirds of deliveries take place at home without the assistance of SBAs in Nepal. We hypothesized that the ability of women to take decisions about their own lives-women's autonomy-plays an important part in birth choices. To know this, we conducted a community-based cross-sectional study for assessing women's autonomy and utilization of safe delivery care service in Kapilvastu district of Nepal from June to October 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28723493/proteinuria-in-patients-undergoing-renal-cancer-surgery-impact-on-overall-survival-and-stability-of-renal-function
#11
Zhiling Zhang, Juping Zhao, Joseph Zabell, Erick Remer, Jianbo Li, Jack Campbell, Wen Dong, Diego Aguilar Palacios, Tulsi Patel, Sevag Demirjian, Steven C Campbell
BACKGROUND: Proteinuria is included in the Kidney Disease: Improving Global Outcomes (KDIGO) risk stratification for chronic kidney disease (CKD) in the general population. However, the importance of proteinuria in patients with renal cancer has not been adequately studied. OBJECTIVE: To evaluate the prognostic impact of preoperative proteinuria on overall survival (OS) and renal function stability (RFS) for patients managed with renal cancer surgery. DESIGN, SETTING, AND PARTICIPANTS: From 1999 to 2008, 977 patients who underwent renal cancer surgery had preoperative data recorded for the glomerular filtration rate (GFR) estimated using the CKD Epidemiology Collaboration equation (G1 ≥90, G2 60-89, G3a 45-59, G3b 30-44, G4 15-29, and G5 <15ml/min/1...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28642488/biomimetic-molecular-signaling-using-dna-walkers-on-microparticles
#12
Tulsi Ram Damase, Adam Spencer, Bamidele Samuel, Peter B Allen
We report the release of catalytic DNA walkers from hydrogel microparticles and the detection of those walkers by substrate-coated microparticles. This might be considered a synthetic biology analog of molecular signal release and reception. One type of particles was coated with components of a DNA one-step strand displacement (OSD) reaction to release the walker. A second type of particle was coated with substrate (or "track") for the molecular walker. We distinguish these particle types using fluorescence barcoding: we synthesized and distinguished multiple particle types with multicolor fluorescence microscopy and automated image analysis software...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625157/purification-of-single-stranded-dna-by-co-polymerization-with-acrylamide-and-electrophoresis
#13
Tulsi Ram Damase, Andrew D Ellington, Peter B Allen
Single-stranded DNA (ssDNA) oligonucleotides are useful as aptamers, hybridization probes and for emerging applications in DNA nanotechnology. Current methods to purify ssDNA require both a strand-separation step and a separate size-separation step but may still leave double-stranded DNA (dsDNA) impurities in the sample. Here, we use commercially available acrydite DNA primers to immobilize one strand of a PCR product within a polyacrylamide matrix. Electrophoresis moves the non-crosslinked DNA into the gel where the single-stranded product of desired size can be recovered...
June 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28607889/outcomes-of-newborn-hearing-screening-program-a-hospital-based-study
#14
Kavita Sachdeva, Tulsi Sao
Hearing loss is hidden disability and second most common congenital pathology. Prevention, early identification and early intervention of hearing loss can prevent further disability in development of speech, language, cognition and other developmental domains. The prevalence of congenital hearing loss has been estimated to be 1.2-5.7 per thousand in neonates. In these contexts, the aim of study was to determine outcomes of neonates hearing screening program in Hospital. It is a clinical cross-sectional study which was conducted in tertiary care centre from 8th July, 2015 to 31th May, 2016...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28584359/regional-anaesthesia-in-a-patient-with-aortic-stenosis-for-bladder-tumour-resection
#15
Aalekh Prasad, Abhik Ghosh, Tulsi Nag
No abstract text is available yet for this article.
May 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28560257/generating-testable-hypotheses-for-schizophrenia-and-rheumatoid-arthritis-pathogenesis-by-integrating-epidemiological-genomic-and-protein-interaction-data
#16
Tulsi A Malavia, Srilakshmi Chaparala, Joel Wood, Kodavali Chowdari, Konasale M Prasad, Lora McClain, Anil G Jegga, Madhavi K Ganapathiraju, Vishwajit L Nimgaonkar
Patients with schizophrenia and their relatives have reduced prevalence of rheumatoid arthritis. Schizophrenia and rheumatoid arthritis genome-wide association studies also indicate negative genetic correlations, suggesting that there may be shared pathogenesis at the DNA level or downstream. A portion of the inverse prevalence could be attributed to pleiotropy, i.e., variants of a single nucleotide polymorphism that could confer differential risk for these disorders. To study the basis for such an interrelationship, we initially compared lists of single nucleotide polymorphisms with significant genetic associations (p < 1(e-8)) for schizophrenia or rheumatoid arthritis, evaluating patterns of linkage disequilibrium and apparent pleiotropic risk profiles...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28511502/comparative-evaluation-of-three-herbal-solutions-on-the-disinfection-of-guttapercha-cones-an-in-vitro-study
#17
Pratap Kumar Mukka, Samba Shiva Rao Pola, Nanda Kumar Kommineni, Mayuri Sailaja Pachalla, Anand Ramtheerth Karne, Karthik Labishetty, Supriya Kommineni, Praveen Chilakabathini
INTRODUCTION: Guttapercha (GP) cones are usually supplied in aseptic, sealed packages from the manufacturers, but once exposed to the dental office environment or even by handling; they can be contaminated by a number of microorganisms. Supplementary decontamination of GP cones is critical. As they cannot be sterilized by moist or dry heat, cold sterilization, using disinfectants should be used. AIM: The aim of the study was to evaluate rapid, reliable, convenient and effective method of disinfection of GP cones using readily available herbal solutions such as Aloevera Juice, Amla Juice and Pancha Tulsi...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28507956/an-unusual-case-of-giant-cell-tumor-of-first-metatarsal-a-rare-case-report-and-review-of-literature
#18
Kumar Prashant, Tulsi Das Bhattacharyya, Herman Frank, Prema Ram
INTRODUCTION: Giant cell tumor (GCT) or osteoclastoma is an osteolytic, mostly benign but locally aggressive tumor occurring in young adults at the epiphysis. Area of predilection is mainly long bones (85-90%). 4% of GCT are also found in iliac bone, spine and only 2% in hand (of which GCT phalanges are more common than metacarpal). GCT of metatarsal is a very rare occurrence with very few cases being reported so far. We report a case of GCT 1(st) metatarsal in a 40-year-old male which is a very rare entity...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28422646/coordinated-control-of-terminal-differentiation-and-restriction-of-cellular-plasticity
#19
Tulsi Patel, Oliver Hobert
The acquisition of a specific cellular identity is usually paralleled by a restriction of cellular plasticity. Whether and how these two processes are coordinated is poorly understood. Transcription factors called terminal selectors activate identity-specific effector genes during neuronal differentiation to define the structural and functional properties of a neuron. To study restriction of plasticity, we ectopically expressed C. elegans CHE-1, a terminal selector of ASE sensory neuron identity. In undifferentiated cells, ectopic expression of CHE-1 results in activation of ASE neuron type-specific effector genes...
April 19, 2017: ELife
https://www.readbyqxmd.com/read/28400848/the-clinical-efficacy-and-safety-of-tulsi-in-humans-a-systematic-review-of-the-literature
#20
REVIEW
Negar Jamshidi, Marc M Cohen
Tulsi, also known as holy basil, is indigenous to the Indian continent and highly revered for its medicinal uses within the Ayurvedic and Siddha medical systems. Many in vitro, animal and human studies attest to tulsi having multiple therapeutic actions including adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, and immunomodulatory effects, yet to date there are no systematic reviews of human research on tulsi's clinical efficacy and safety. We conducted a comprehensive literature review of human studies that reported on a clinical outcome after ingestion of tulsi...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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