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https://www.readbyqxmd.com/read/29914034/genotyping-of-the-alzheimer-s-disease-genome-wide-association-study-index-single-nucleotide-polymorphisms-in-the-brains-for-dementia-research-cohort
#1
Keeley J Brookes, George McConnell, Kirsty Williams, Sultan Chaudhury, Gaganjit Madhan, Tulsi Patel, Christopher Turley, Tamar Guetta-Baranes, Jose Bras, Rita Guerreiro, John Hardy, Paul T Francis, Kevin Morgan
The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer's disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOEɛ4 allele was identified (p = 3.99×10-12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al...
June 8, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29908572/medicinal-plants-with-traditional-use-ethnobotany-in-the-indian-subcontinent
#2
Reena Rupani, Afton Chavez
Traditional medicine uses cultural knowledge and practices to promote health maintenance as well as diagnose and treat disease. In developing countries, the majority of people rely on traditional medicines; however, many of these practices have not been rigorously and systematically studied or reported. We review the current understanding and research behind traditional therapies prevalent in the Indian subcontinent, including mind-body and energy-based healing, botanical medicine, and herbal remedies. Topics covered include Ayurveda, yoga, naturopathy, Unani, Siddha, Sowa-Rigpa, homeopathy, and medicinal plants such as neem, guggul, tulsi, amla, and turmeric...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29900603/the-enigmatic-role-of-the-neutrophil-in-asthma-friend-foe-or-indifferent
#3
Robert J Snelgrove, Dhiren F Patel, Tulsi Patel, Clare M Lloyd
Whilst severe asthma has classically been categorised as a predominantly Th2 driven pathology, there has in recent years been a paradigm shift with the realisation that it is a heterogeneous disease that may manifest with quite disparate underlying inflammatory and remodelling profiles. A subset of asthmatics, particularly those with a severe, corticosteroid refractory disease, present with a prominent neutrophilic component. Given the potential of neutrophils to impart extensive tissue damage and promote inflammation, it has been anticipated that these cells are closely implicated in the underlying pathophysiology of severe asthma...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29807714/perioperative-evaluation-and-surgical-management-of-a-patient-with-a-pericardial-hemangioma-abutting-the-right-ventricular-outflow-tract-and-main-pulmonary-artery
#4
Tulsi Akikwala, Dhaval Trivedi, Gary Kochamba, Kartik Kansagra, Sreevathsan Sridhar, Andrew G Rudikoff, Antonio Hernandez Conte
No abstract text is available yet for this article.
April 27, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29756672/successful-conservative-management-of-an-intramural-gastric-abscess-a-case-report
#5
Joshua Salim, Tulsi Menon, Robert Drummond, Philip L Page, Gregory Falk
No abstract text is available yet for this article.
May 14, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29728546/-in-vitro-antimicrobial-activity-of-ocimum-sanctum-tulsi-extract-on-aggregatibacter-actinomycetemcomitans-and-porphyromonas-gingivalis
#6
Ipsita Jayanti, Md Jalaluddin, Anisha Avijeeta, Pavithra K Ramanna, Pooja M Rai, Rohit A Nair
Aim: The present study was conducted with an aim to assess the antimicrobial activity of Ocimum sanctum (tulsi) extract on Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Materials and methods: Tulsi extract with ethanol was prepared using cold extraction method in the present in vitro study. Various concentrations (2, 4, 6, and 8%) were then obtained by dilution with dimethylformamide. A 0.2% chlorhexidine served as the positive control, whereas the negative control was dimeth-ylformamide...
April 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29724068/addressing-the-mental-health-needs-of-black-american-youth-and-families-a-case-study-from-the-embrace-intervention
#7
Riana E Anderson, Shawn C T Jones, Crystal C Navarro, Monique C McKenny, Tulsi J Mehta, Howard C Stevenson
Black American youth are vulnerable to the consequences of repeated exposure to racial discrimination, particularly through hampered coping abilities and greater internalizing and externalizing problems. One way in which Black American parents have protected their children from these deleterious consequences is through racial socialization, or communication regarding aspects of racialized experiences and contexts. Less is known, however, about the potential therapeutic benefits of racial socialization via clinical intervention...
May 2, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29717294/bullying-behavior-and-psychosocial-health-a-cross-sectional-study-among-school-students-of-pyuthan-municipality
#8
Durga Khadka Mishra, Tulsi Ram Thapa, Sujan Babu Marahatta, Anita Mahotra
BACKGROUND: Bullying remains as pervasive phenomenon affecting children worldwide. Bullying in school has long been a matter of concern as wide range of adjustment problems including poor mental health and violent behavior in school are associated with it. The present study examined the prevalence of bullying behavior (bullies, victims and bully-victims) and their association with depression and psychosomatic symptoms. METHODS: A cross-sectional descriptive study was carried out among 8th, 9th and 10th grade students of Pyuthan Municipality, Mid-Western Nepal...
March 13, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29673152/beneficial-effect-of-ocimum-sanctum-linn-against-monocrotaline-induced-pulmonary-hypertension-in-rats
#9
Himanshu Meghwani, Pankaj Prabhakar, Soheb A Mohammed, Pamila Dua, Sandeep Seth, Milind P Hote, Sanjay K Banerjee, Sudheer Arava, Ruma Ray, Subir Kumar Maulik
BACKGROUND: The study was designed to explore any beneficial effect of Ocimum sanctum (Linn) (OS) in experimental pulmonary hypertension (PH) in rats. OS is commonly known as “holy basil” and “Tulsi” and is used in the Indian System of Medicine as antidiabetic, antioxidant, hepatoprotective, adaptogenic, and cardioprotective. METHODS: Monocrotaline (MCT) administration caused development of PH in rats after 28 days and rats were observed for 42 days...
April 17, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29567949/ocimum-flavone-orientin-as-a-countermeasure-for-thrombocytopenia
#10
Marshleen Yadav, Feifei Song, Jason Huang, Arnab Chakravarti, Naduparambil K Jacob
Thrombocytopenia or chronic depletion of platelets in blood, could create life-threatening conditions in patients who receive aggressive systemic radiation and chemotherapy. Currently there are no approved agents for the rapid treatment of thrombocytopenia. In the present study, we demonstrate that administration of Orientin, a glycosidic flavonoid or dietary administration of Orientin containing Tulsi (Holy Basil) leaves, results in a significant increase in circulating platelets in a clinically relevant mouse model...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29546661/sleep-pattern-of-adolescents-in-a-school-in-delhi-india-impact-on-their-mood-and-academic-performance
#11
Ruchi Singh, Jagdish C Suri, Renuka Sharma, Tejas Suri, Tulsi Adhikari
OBJECTIVES: To examine the sleep pattern and observe differences in sleep routines, phase preferences, mood, attendance, and academic performance among different adolescent age students. Secondly, to observe the age at which sleep phase transition and changes in sleep requirement become evident. METHODS: A cross-sectional study was conducted among 501 students (aged 11-15 y) of a school in Delhi, India. Students were evaluated for their sleep patterns, sleep duration, habits of napping, quality of sleep, sleepiness, depression, phase preferences by self-reported school sleep habits survey questionnaire along with school performance and attendance...
March 16, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29476116/hmg-coa-reductase-from-camphor-tulsi-ocimum-kilimandscharicum-regulated-mva-dependent-biosynthesis-of-diverse-terpenoids-in-homologous-and-heterologous-plant-systems
#12
Shilpi Bansal, Lokesh Kumar Narnoliya, Bhawana Mishra, Muktesh Chandra, Ritesh Kumar Yadav, Neelam Singh Sangwan
Ocimum kilimandscharicum is unique in possessing terpenoids whereas other Ocimum species are renowned for phenylpropanoids as major constituents of essential oil. The key enzyme of MVA/terpenoid metabolic pathway viz 3-hydroxy-3-methylglutaryl Co-A reductase (OkHMGR) of 1.7-Kb ORF encoding ~60-kDa protein was cloned from O. kilimandscharicum and its kinetic characteristics revealed the availability of HMG-CoA as a control point of MVA-pathway. Transcript profiling of the OkHMGR elucidated tissue-specific functions of the gene in flower and leaf tissues in accumulation of terpenoidal essential oil...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29353895/workplace-violence-and-its-associated-factors-among-nurses
#13
Manisha Pandey, Tulsi Ram Bhandari, Ganesh Dangal
BACKGROUND: Workplace violence among nurses is prevalent worldwide. If nurses become aware of the workplace violence and its risk factors then only they can protect themselves. This study assessed the prevalence of workplace violence and its associated factors among nurses in Pokhara, Nepal. METHODS: A hospital-based descriptive cross-sectional study was conducted in Pokhara. The required sample size of the study was 200 nurses. We adopted self-administered questionnaire developed by International Labor Office, International Council of Nurses, World Health Organization (WHO), and Public Services International...
January 1, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29343181/experiencing-abortion-rights-in-india-through-issues-of-autonomy-and-legality-a-few-controversies
#14
Tulsi Patel
Abortion laws in India, like other laws, are premised on the 1861 British Penal Code. The Medical Termination of Pregnancy Act was passed in 1971 to circumvent the criminality clause around abortion. Yet the law continues to render invisible women's right to choose. Legal procedures have often hindered in permitting abortion, resulting in the death of a mother or the foetus. Despite the latest techno-medical advances, the laws have remained stagnant or rather restrictive, complicated further by selective female foetus abortions...
January 17, 2018: Global Public Health
https://www.readbyqxmd.com/read/29319027/comparison-of-diagnostic-yield-and-safety-profile-of-radial-endobronchial-ultrasound-guided-bronchoscopic-lung-biopsy-with-computed-tomography-guided-percutaneous-needle-biopsy-in-evaluation-of-peripheral-pulmonary-lesions-a-randomized-controlled-trial
#15
Ayush Gupta, Jagdish Chander Suri, Dipak Bhattacharya, Manas Kamal Sen, Shibdas Chakrabarti, Abhijeet Singh, Tulsi Adhikari
BACKGROUND: Peripheral pulmonary lesions (PPLs) pose a diagnostic challenge, and the optimal investigation in many such cases remains unclear. Computed tomography (CT)-guided percutaneous needle biopsy (CT-PNB) has been the modality of choice for such lesions with a high diagnostic accuracy but with high rates of pneumothorax. Endobronchial ultrasound (EBUS) with a radial probe is an alternate diagnostic modality with increased diagnostic yield of bronchoscopy in the evaluation of PPL...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29303875/outcome-following-laser-peripheral-iridotomy-and-predictors-of-future-lens-extraction
#16
Jenny Bo, Tulsi Changulani, Mei-Ling Cheng, Andrew J Tatham
PURPOSE: To examine the outcome of laser peripheral iridotomy (LPI) for primary angle closure and determine predictors of future lens extraction (LE). METHODS: A retrospective chart review of 218 eyes from 128 consecutive patients undergoing LPI between 2010 and 2012 at a university hospital. Baseline factors including age, peak intraocular pressure (IOP) before LPI, diagnosis (primary angle closure suspect, primary angle closure, primary angle closure glaucoma), and acute or non-acute presentation were recorded...
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29279446/the-status-of-susceptibility-of-japanese-encephalitis-vectors-to-insecticides-in-endemic-areas-of-northern-districts-of-west-bengal-india
#17
Pabitra Saha, Sudeep Ballav, Moytrey Chatterjee, Swagata Ganguly, Mayukh Sarker, Asit Kumar Biswas, Tulsi Pramanik, Nandita Basu, Ardhendu Kumar Maji
Emergence and spread of resistance among vectors toward different insecticides is a serious problem for the Japanese encephalitis (JE) control program. Regularly monitoring the status of susceptibility of vector species to insecticides is important for formulating proper vector control measures. In this study, we studied the susceptibility status of major JE vectors from northern West Bengal, toward 4% DDT, 0.05% deltamethrin, and 5% malathion. Two- to three-day-old unfed female mosquitoes were subjected to a susceptibility bioassay using a World Health Organization kit...
March 22, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29181857/whole-exome-sequencing-of-the-bdr-cohort-evidence-to-support-the-role-of-the-pilra-gene-in-alzheimer-s-disease
#18
T Patel, K J Brookes, J Turton, S Chaudhury, T Guetta-Baranes, R Guerreiro, J Bras, D Hernandez, A Singleton, P T Francis, J Hardy, K Morgan
AIM: Late-onset Alzheimer's disease (LOAD) accounts for 95% of all Alzheimer's cases and is genetically complex in nature. Overlapping clinical and neuropathological features between AD, FTD and Parkinson's disease highlight the potential role of genetic pleiotropy across diseases. Recent genome-wide association studies (GWASs) have uncovered 20 new loci for AD risk; however, these exhibit small effect sizes. Using NGS, here we perform association analyses using exome-wide and candidate-gene-driven approaches...
November 27, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29158537/medicinal-plant-leaf-extract-and-pure-flavonoid-mediated-green-synthesis-of-silver-nanoparticles-and-their-enhanced-antibacterial-property
#19
Siddhant Jain, Mohan Singh Mehata
The rewards of using plants and plant metabolites over other biological methods for nanoparticle synthesis have fascinated researchers to investigate mechanisms of metal ions uptake and bio-reduction by plants. Here, green chemistry were employed for the synthesis of silver nanoparticles (AgNPs) using leaf extracts of Ocimum Sanctum (Tulsi) and its derivative quercetin (flavonoid present in Tulsi) separately as precursors to investigate the role of biomolecules present in Tulsi in the formation of AgNPs from cationic silver under different physicochemical conditions such as pH, temperature, reaction time and reactants concentration...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29123996/herbal-combat-against-e-faecalis-an-in-vitro-study
#20
Shipra Jaidka, Rani Somani, Deepti Jawa Singh, Tasneem Sheikh, Nidhi Chaudhary, Asiya Basheer
Background: Herbs have renewed importance in this modern era for their antimicrobial properties and fewer side effects. So a novel idea to use these herbs for pulpectomy; was implemented. There are chances of failure of pulpectomy due to inefficient removal of microbial load. Thus, for a successful endodontic treatment, obturating material with optimum antimicrobial properties is advocated in the present study. Aim: To compare and evaluate the antibacterial efficacy of zinc oxide eugenol, zinc oxide with tulsi extract and zinc oxide with aloe vera as obturating materials against E...
September 2017: Journal of Oral Biology and Craniofacial Research
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