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https://www.readbyqxmd.com/read/28806274/transfusion-related-immunomodulation-a-reappraisal
#1
Lyla A Youssef, Steven L Spitalnik
PURPOSE OF REVIEW: This review summarizes current and prior observations regarding transfusion-related immunomodulation (TRIM) and puts these ideas into a modern immunological context, incorporating concepts from innate, adaptive, and nutritional immunity. We propose that TRIM research focus on determining whether there are specific, well-defined immunosuppressive effects from transfusing 'pure' red blood cells (RBCs) themselves, along with the by-products produced by the stored RBCs as a result of the 'storage lesion...
August 12, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28750040/oral-administration-of-live-or-heat-killed-candida-albicans-worsened-cecal-ligation-and-puncture-sepsis-in-a-murine-model-possibly-due-to-an-increased-serum-1%C3%A2-3-%C3%AE-d-glucan
#2
Wimonrat Panpetch, Naraporn Somboonna, Dewi Embong Bulan, Jiraphorn Issara-Amphorn, Malcolm Finkelman, Navaporn Worasilchai, Ariya Chindamporn, Tanapat Palaga, Somying Tumwasorn, Asada Leelahavanichkul
Candida albicans is the most common fungus in the human intestinal microbiota but not in mice. To make a murine sepsis model more closely resemble human sepsis and to explore the role of intestinal C. albicans, in the absence of candidemia, in bacterial sepsis, live- or heat-killed C. albicans was orally administered to mice at 3h prior to cecal ligation and puncture (CLP). A higher mortality rate of CLP was demonstrated with Candida-administration (live- or heat-killed) prior to CLP. Fecal Candida presented only in experiments with live-Candida administration...
2017: PloS One
https://www.readbyqxmd.com/read/28738674/complex-consisting-of-%C3%AE-glucan-and-antigenic-peptides-with-cleavage-site-for-glutathione-and-aminopeptidases-induces-potent-cytotoxic-t-lymphocytes
#3
Shinichi Mochizuki, Hiromi Morishita, Kazuo Sakurai
The efficient induction of antigen-specific immune responses requires not only promotion of the uptake of antigens and adjuvant molecules into antigen-presenting cells, but also control of their intracellular behavior. We previously demonstrated that the β-glucan schizophyllan (SPG) can form complexes with CpG oligonucleotides with attached dA40 (CpG-dA/SPG), which can accumulate in macrophages in the draining inguinal lymph nodes and induce strong immune responses. In this study, we prepared various conjugates comprising antigenic peptide (OVA257-264) and dA40, and made complexes with SPG...
July 24, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28715863/structural-elucidation-of-a-pectin-type-polysaccharide-from-hovenia-dulcis-peduncles-and-its-proliferative-activity-on-raw264-7-cells
#4
Miaomiao Wang, Yong Liu, Mingliang Qiang, Junhui Wang
In this paper, an acidic polysaccharide HDP3A was isolated from Hovenia dulcis peduncles with 45.9% of uronic acid content. Structure of HDP3A was elucidated by chemical and spectroscopic analysis. HDP3A was mainly contained of galacturonic acid, galactose, rhamnose and arabinose with a small quantity of xylose, fucose, mannose, glucose. The structural analysis indicated that HDP3A was a pectin-type polysaccharide with HG and RG-I regions and hairy regions. HG was linear homopolymer with repeating units of (1→4)-α-d-galactopyranosyl uronic (GalA) residues...
July 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28645771/dectin-1-expression-by-macrophages-and-related-antifungal-mechanisms-in-a-murine-model-of-sporothrix-schenckii-sensu-stricto-systemic-infection
#5
Juliana Aparecida Jellmayer, Lucas Souza Ferreira, Francine Alessandra Manente, Amanda Costa Gonçalves, Marisa Campos Polesi, Alexander Batista-Duharte, Iracilda Zeppone Carlos
The available information about the role of Dectin-1 in sporotrichosis is scarce. Hence, we aimed to assess Dectin-1 expression by macrophages and the activation of some related antifungal mechanisms during the Sporothrix schenckii sensu stricto infection as a first attempt to elucidate the role of this receptor in sporotrichosis. Balb/c mice were intraperitoneally infected with S. schenckii sensu stricto yeast ATCC 16345 and euthanized on days 5, 10 and 15 post-infection, when the following parameters were evaluated: fungal burden in spleen, Dectin-1 expression and nitric oxide (NO) production by peritoneal macrophages, as well as IL-1β, TNF-α and IL-10 ex vivo secretion by these same cells...
June 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28611507/a-proinflammatory-effect-of-the-%C3%AE-glucan-from-pleurotus-cornucopiae-mushroom-on-macrophage-action
#6
Ken-Ichiro Minato, Akihiro Ohara, Masashi Mizuno
PCPS from P. citrinopileatus mushroom extract is a β-1,6-glucan possessing a proinflammatory effect on innate immune cells. The PCPS stimulated THP-1 macrophages to secrete significant levels of TNF. Moreover, the mRNA expressions of TNF and IL-1β were significantly enhanced by PCPS treatment. However, the PCPS did not induce to express both IL-12 and IL-10 mRNA in the macrophages. Next, the P. cornucopiae extract (containing mainly PCPS) treatment against mice showed significant increases in TNF and IL-1β mRNA expressions in the peritoneal macrophages of them...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28602993/modulation-of-an-innate-immune-response-by-soluble-yeast-%C3%AE-glucan-prepared-by-a-heat-degradation-method
#7
Yuina Ishimoto, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Ken Kanzaki, Kumiko Okita, Yoichiro Iwakura, Naohito Ohno
β-glucan is widely distributed in nature as water soluble and insoluble forms. Both forms of β-glucan are applied in several fields, especially for functional foods. Yeast β-glucan is a medically important insoluble particle. Solubilization of yeast β-glucan may be a valuable approach to increase functional foods and medicinal fields. We have applied a heat degradation method to solubilize yeast β-glucan and found that it was effectively solubilized by treatment with an aqueous suspension at 135°C for several hours...
June 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28584989/beta-glucan-particles-as-vaccine-adjuvant-carriers
#8
Zeynep Mirza, Ernesto R Soto, Fusun Dikengil, Stuart M Levitz, Gary R Ostroff
Glucan particles (GPs) are spherical hollow particles derived from Saccharomyces cerevisiae cell walls and mainly consist of β-1, 3-D-glucans. The inner hollow cavity of glucan particles can be loaded with different compounds, including protein antigens, and delivered to macrophages and dendritic cells. Moreover, the GP delivery system possesses β-glucan's intrinsic immunostimulatory properties. Therefore, GPs serve as both an antigen-presenting cell-targeted delivery system and an adjuvant.Here, we describe the production of GPs from S...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28542528/adaptation-of-candida-albicans-to-environmental-ph-induces-cell-wall-remodelling-and-enhances-innate-immune-recognition
#9
Sarah L Sherrington, Eleanor Sorsby, Nabeel Mahtey, Pizga Kumwenda, Megan D Lenardon, Ian Brown, Elizabeth R Ballou, Donna M MacCallum, Rebecca A Hall
Candida albicans is able to proliferate in environments that vary dramatically in ambient pH, a trait required for colonising niches such as the stomach, vaginal mucosal and the GI tract. Here we show that growth in acidic environments involves cell wall remodelling which results in enhanced chitin and β-glucan exposure at the cell wall periphery. Unmasking of the underlying immuno-stimulatory β-glucan in acidic environments enhanced innate immune recognition of C. albicans by macrophages and neutrophils, and induced a stronger proinflammatory cytokine response, driven through the C-type lectin-like receptor, Dectin-1...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28535995/inflammation-associated-gene-expression-in-raw-264-7-macrophages-induced-by-toxins-from-fungi-common-on-damp-building-materials
#10
Thomas G Rand, Carolyn T Chang, David R McMullin, J David Miller
Most fungi that grow on damp building materials produce low molecular weight compounds, some of which are known to be toxic. In this study, we tested the hypothesis that exposure to some metabolites of fungi common on damp building materials would result in time-, dose-, and compound-specific responses in the production of various chemokines by RAW 264.7 cells. Cell cultures were exposed to a 10(-7)M or 10(-8)M metabolite dose for 2, 4, 8 or 24h. Metabolite concentrations used were based on those that might be expected in alveolar macrophages due to inhalation exposure from living or working in a damp building...
May 20, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28507467/preparation-and-characterization-of-beta-glucan-particles-containing-a-payload-of-nanoembedded-rifabutin-for-enhanced-targeted-delivery-to-macrophages
#11
Tarun K Upadhyay, Nida Fatima, Deepak Sharma, V Saravanakumar, Rolee Sharma
β-glucan particles (GP) are polymeric carbohydrates, mainly found as components of cell wall fungi, yeast, bacteria and also in cereals such as barley and oat, and have been recently shown to have application in macrophage-targeted drug delivery. The aim of this study was to prepare and characterize GP containing a large payload of Rifabutin (RB), an anti-tuberculosis drug effective against MDR-TB at lower MIC than Rifampicin. GP were prepared from yeast cells by acidic and alkaline extraction were either spray dried or lyophilized, prior to RB loading and alginate sealing...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28498297/gastrointestinal-colonization-of-candida-albicans-increases-serum-1%C3%A2-3-%C3%AE-d-glucan-without-candidemia-and-worsens-cecal-ligation-and-puncture-sepsis-in-murine-model
#12
Wimonrat Panpetch, Naraporn Somboonna, Dewi Embong Bulan, Jiraphorn Issara-Amphorn, Navaporn Worasilchai, Malcolm Finkelman, Ariya Chindamporn, Tanapat Palaga, Somying Tumwasorn, Asada Leelahavanichkul
The role of intestinal Candida albicans in bacterial sepsis, in the absence of candidemia, was investigated in murine models. Live C. albicans or normal saline solution (NSS) was administered orally once, followed by 5 days of daily oral antibiotic-mixtures (ATB). Cecal ligation and puncture (CLP) was then performed to induce sepsis.Fecal Candida was detected by culture only in models with Candida administration. Oral Candida administration with/without ATB enhanced gut-pathogenic bacteria as determined by microbiome analysis...
May 11, 2017: Shock
https://www.readbyqxmd.com/read/28465544/lentinan-from-shiitake-selectively-attenuates-aim2-and-non-canonical-inflammasome-activation-while-inducing-pro-inflammatory-cytokine-production
#13
Huijeong Ahn, Eunsaem Jeon, Jin-Chul Kim, Seung Goo Kang, Sung-Il Yoon, Hyun-Jeong Ko, Pyeung-Hyeun Kim, Geun-Shik Lee
Lentinan extracted from shiitake (Lentinula edodes) is a β-glucan that has been reported as an intravenous anti-tumor polysaccharide via enhancement of the host immune system. In this study, we determined the effect of lentinan on inflammasome activation, a multi-protein platform, in myeloid cells. Mouse bone marrow-derived macrophages were treated with lentinan with/without inflammasome triggers, and maturation of interleukin (IL)-1β, IL-18, or caspase-1 was measured as a readout of inflammasome activation...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28278221/antitumor-activity-of-orally-administered-maitake-%C3%AE-glucan-by-stimulating-antitumor-immune-response-in-murine-tumor
#14
Yuki Masuda, Yoshiaki Nakayama, Akihiro Tanaka, Kenta Naito, Morichika Konishi
Maitake α-glucan, YM-2A, isolated from Grifola frondosa, has been characterized as a highly α-1,6-branched α-1,4 glucan. YM-2A has been shown to possess an anti-virus effect in mice; however, it does not directly inhibit growth of the virus in vitro, indicating that the anti-virus effect of YM-2A might be associated with modulation of the host immune system. In this study, we found that oral administration of YM-2A could inhibit tumor growth and improve survival rate in two distinct mouse models of colon-26 carcinoma and B16 melanoma...
2017: PloS One
https://www.readbyqxmd.com/read/28266184/water-solubilization-of-fullerene-derivatives-by-%C3%AE-1-3-1-6-d-glucan-and-their-photodynamic-activities-toward-macrophages
#15
Atsushi Ikeda, Tatsuya Iizuka, Naotake Maekubo, Kazuyuki Nobusawa, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Motofusa Akiyama
Anionic and neutral fullerene derivatives were dissolved in water by using β-(1,3-1,6)-d-glucan (β-1,3-glucan) as a solubilizing agent. In the water-solubilized complexes, the concentrations of fullerene derivatives were ≈0.30 mm and the average particle sizes were ≈90 nm. The β-1,3-glucan-complexed fullerene derivative with a carboxylic acid was found to have higher photodynamic activity toward macrophages under visible-light irradiation (λ>610 nm) than other β-1,3-glucan-complexed fullerene derivatives...
May 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28228641/evaluation-of-trained-immunity-by-%C3%AE-1-3-d-glucan-on-murine-monocytes-in-vitro-and-duration-of-response-in-vivo
#16
Pablo Garcia-Valtanen, Ruth Marian Guzman-Genuino, David L Williams, John D Hayball, Kerrilyn R Diener
The β-1, 3 (d)-glucan (β-glucan) present in the cell wall of Candida albicans induces epigenetic changes in human monocytes resulting in primed macrophages exhibiting increased cytokine responsiveness to reinfection. This phenomenon is referred to as trained immunity or innate immune memory. However, whether β-glucan can reprogramme murine monocytes in vitro or induce lasting effects in vivo has yet to be elucidated. Thus, purified murine spleen-derived monocytes were primed with β-glucan in vitro and assessed for markers of differentiation and survival...
August 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28182518/clinical-evaluation-of-a-bioactive-beta-glucan-gel-in-the-treatment-of-hard-to-heal-wounds
#17
B King, S Barrett, K F Cutting
OBJECTIVE: The aim of this evaluation is to assess the effects of a wound healing gel in a wounds of different aetiologies. METHOD: Data was recorded on the wound surface area, tissue type, and patient level of wound pain at baseline (0) and at weeks 1, 2, 3, 4, and 8. RESULTS: Of the total 39 patients enrolled in the study, 26 patients who complied with the protocol criteria completed the minimum four-week study period. During the 12-week evaluation period, seven of the 26 wounds fully healed and an additional eight wounds showed a reduction in size of more than 50 %...
February 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28177008/formation-of-%C3%AE-1-3-1-6-d-glucan-complexed-70-fullerene-and-its-photodynamic-activity-towards-macrophages
#18
Atsushi Ikeda, Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yuta Kashijima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki
[70]Fullerene was dissolved in water by complexation with β-1,3-glucan using a mechanochemical high-speed vibration milling apparatus. The photodynamic activity of β-1,3-glucan-complexed C70 was highly dependent on the expression level of dectin-1 on the cell surfaces of macrophages. The photodynamic activity increased as a result of a synergistic effect between β-1,3-glucan-complexed 1'-acetoxychavicol acetate and the C70 complex.
February 8, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27965897/targeted-delivery-of-glucan-particle-encapsulated-gallium-nanoparticles-inhibits-hiv-growth-in-human-macrophages
#19
Ernesto R Soto, Olivia O'Connell, Fusun Dikengil, Paul J Peters, Paul R Clapham, Gary R Ostroff
Glucan particles (GPs) are hollow, porous 3-5 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encapsulated inside the hollow GPs or bound to the surface of chemically derivatized GPs. Gallium nanoparticles have been proposed as an inhibitory agent against HIV infection...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27876596/characterization-and-immunomodulatory-effects-of-glucans-from-pleurotus-albidus-a-promising-species-of-mushroom-for-farming-and-biomass-production
#20
Victor Costa Castro-Alves, Daniel Gomes, Nelson Menolli, Maurício Luís Sforça, João Roberto Oliveira do Nascimento
Polysaccharides from a number of mushroom species are recognized as functional food ingredients with potential health benefits, including immunomodulatory effects. In this study, polysaccharides extracted from the basidiome with cold water (BaCW), hot water (BaHW), and hot alkali (BaHA) solution, and exo- (MyEX) and endopolysaccharides (MyEN) from the submerged culture of Pleurotus albidus, a promising species for farming and biomass production, were analyzed for their chemical composition and structure and immunomodulatory effects on macrophages...
February 2017: International Journal of Biological Macromolecules
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