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Addiction; methadone

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https://www.readbyqxmd.com/read/28635521/assessment-of-an-innovative-voluntary-substance-abuse-treatment-program-designed-to-replace-compulsory-drug-detention-centers-in-malaysia
#1
Farrah Khan, Archana Krishnan, Mansur A Ghani, Jeffrey A Wickersham, Jeannia J Fu, Sin How Lim, Sangeeth Kaur Dhaliwal, Adeeba Kamarulzaman, Frederick L Altice
BACKGROUND: As part of an ongoing initiative by the Malaysian government to implement alternative approaches to involuntary detention of people who use drugs, the National Anti-Drug Agency has created new voluntary drug treatment programs known as Cure and Care (C&C) Centers that provide free access to addiction treatment services, including methadone maintenance therapy, integrated with social and health services. OBJECTIVES:   We evaluated early treatment outcomes and client satisfaction among patients accessing C&C treatment and ancillary services at Malaysia's second C&C Center located in Kota Bharu, Kelantan...
February 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28632076/association-of-oprd1-gene-variants-with-opioid-dependence-in-addicted-male-individuals-undergoing-methadone-treatment-in-the-north-of-iran
#2
Alireza Sharafshah, Hedyeh Fazel, Ali Albonaim, Vahid Omarmeli, Sajjad Rezaei, Ebrahim Mirzajani, Farzam Ajamian, Parvaneh Keshavarz
Genetic association of rs678849 along with neuroimaging and biomarker phenotypes, parallel with the known involvements of the OPRD1 in drug abuse, provided additional support for targeting these receptors as potential therapeutic targets in both neurodegenerative diseases and neuropsychiactric disorders such as Alzheimer's disease. Samples were selected among 202 opium-addicted participants undergoing methadone treatment and 202 healthy controls. Genomic DNA of all subjects was extracted from whole blood samples through a Salting Out procedure...
March 1, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28611509/hepatitis-c-in-injection-drug-users-it-is-time-to-treat
#3
EDITORIAL
Alberto Grassi, Giorgio Ballardini
Injection drug users (IDUs) are at risk of hepatitis C virus (HCV) infection, due to needle and syringe sharing. Chronic HCV infection is a major cause of liver-related morbidity and mortality but can be cured with antiviral treatment leading to sustained viral response (SVR). It is well demonstrated that, when close cooperation between specialists in drug addiction and psychiatrists is assured, patients on maintenance treatment with methadone/buprenorphine can be treated for HCV with response rate, tolerability and side effects similar to those reported in non-IDUs...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28586356/bidirectional-relationships-between-retention-and-health-related-quality-of-life-in-chinese-mainland-patients-receiving-methadone-maintenance-treatment
#4
Kaina Zhou, Duolao Wang, Hengxin Li, Xiaoli Wei, Juan Yin, Peifeng Liang, Lingling Kou, Mengmeng Hao, Lijuan You, Xiaomei Li, Guihua Zhuang
This study aimed to explore the bidirectional relationships between retention and health-related quality of life (HRQoL) in patients from mainland China receiving methadone maintenance treatment (MMT). This prospective cohort study recruited 1,212 eligible MMT patients from the two largest MMT clinics (one privately and another publicly funded) in Xi'an. This study started in March 2012 with a 2-year follow-up until March 2014. Retention was assessed by repeated terminations, past treatment duration, premature terminations, and follow-up treatment duration...
2017: PloS One
https://www.readbyqxmd.com/read/28571505/buprenorphine-implants-in-medical-treatment-of-opioid-addiction
#5
Steven Chavoustie, Michael Frost, Ole Snyder, Joel Owen, Mona Darwish, Ryan Dammerman, Victoria Sanjurjo
Opioid use disorder is a chronic, relapsing disease that encompasses use of both prescription opioids and heroin and is associated with a high annual rate of overdose deaths. Medical treatment has proven more successful than placebo treatment or psychosocial intervention, and the partial µ-opioid receptor agonist and κ-opioid receptor antagonist buprenorphine is similar in efficacy to methadone while offering lower risk of respiratory depression. However, frequent dosing requirements and potential for misuse and drug diversion contribute to significant complications with treatment adherence for available formulations...
June 21, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28546740/new-developments-in-managing-opioid-addiction-impact-of-a-subdermal-buprenorphine-implant
#6
REVIEW
MariaLisa Itzoe, Michael Guarnieri
Opioid addiction to prescription and illicit drugs is a serious and growing problem. In the US alone, >2.4 million people suffer from opioid use disorder. Government and pharmaceutical agencies have begun to address this crisis with recently released and revised task forces and medication-assisted therapies (MAT). For decades, oral or intravenous (IV) MATs have helped patients in their recovery by administration of opioid agonists (methadone, buprenorphine, oxycodone), antagonists (naltrexone, naloxone), and combinations of the two (buprenorphine/naloxone)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28530896/use-and-misuse-of-opioid-agonists-in-opioid-addiction
#7
REVIEW
Vania Modesto-Lowe, Katie Swiezbin, Margaret Chaplin, Gabriela Hoefer
Although methadone (an opioid agonist) and buprenorphine (a partial opioid agonist) have evidence to support their use in treating opioid use disorder, they remain misunderstood and underutilized. In this article, we outline the risks and benefits of using these drugs as maintenance therapy in opioid-dependent patients.
May 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28525291/the-state-of-opioid-agonist-therapy-in-canada-20-years-after-federal-oversight
#8
Joseph K Eibl, Kristen Morin, Esa Leinonen, David C Marsh
Opioid agonist therapy was introduced in Canada in 1959 with the use of methadone for the treatment of opioid dependence. The regulation of methadone was the responsibility of Health Canada until 1995, when oversight was transferred to the provincial health systems. During the more than 20 years since the federal health authority transferred oversight of methadone to the provincial level, methadone programming has evolved differently in every province. The landscape of opioid dependence treatment is varied across the country, with generally increasing treatment capacity in all provinces and dramatic increases in some...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28513227/temporal-relationship-of-sex-risk-behaviors-and-substance-use-severity-among-men-in-substance-use-treatment
#9
Howard Newville, James L Sorensen, Mary Hatch-Maillette, Donald A Calsyn
Sex risk behaviors and substance use are intertwined. Many men continue to engage in high-risk sexual behaviors even when enrolled in substance use disorder (SUD) treatment. We hypothesized that changes in sex risk behaviors would coincide with changes in drug/alcohol use severity among men in SUD treatment. During an HIV risk-reduction trial, men in methadone maintenance and outpatient drug-free treatment (N = 359) completed assessments at baseline and six months after. We assessed changes in sex risk and substance use severity, using the Addiction Severity Index-Lite (ASI-Lite), controlling for treatment condition...
May 17, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28488881/mindfulness-based-relapse-prevention-for-methadone-maintenance-a-feasibility-trial
#10
Sarah Bowen, Vanessa C Somohano, Rachel E Rutkie, Jacob A Manuel, Kristoffer L Rehder
OBJECTIVES: As rates of opiate misuse rise in the United States, so do significant associated health and financial consequences to afflicted individuals, their families, and society at large. Methadone maintenance therapy (MMT) is one evidence-based approach to treating opiate addiction, yet supplemental psychosocial treatment to support this approach is lacking. Mindfulness-based relapse prevention (MBRP) has shown to be efficacious in various substance use populations, but has yet to be assessed with MMT clients...
May 10, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28485905/-shifting-from-heroin-to-alcohol-addiction-descriptive-survey
#11
Sergio Borsetti, Johnny Acquaro, Emanuele Bignamini
INTRODUCTION: Addiction is a disease which affects the relation between the person and the object of his addiction. One of the major risks for people addicted to heroin treated with Methadone Maintenance Treatment (MMT) is to develop addiction from another substance, particularly alcohol, while treating heroin addiction, "shifting" this way from heroin addic- tion to alcoholism. OBJECTIVE: describing such "shifting" process within the population taken into considera- tion for this study...
January 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/28485671/biased-and-less-sensitive-a-gamified-approach-to-delay-discounting-in-heroin-addiction
#12
Stefan Scherbaum, Paul Haber, Kirsten Morley, Dylan Underhill, Ahmed A Moustafa
INTRODUCTION: People with addiction will continue to use drugs despite adverse long-term consequences. We hypothesized (a) that this deficit persists during substitution treatment, and (b) that this deficit might be related not only to a desire for immediate gratification, but also to a lower sensitivity for optimal decision making. We investigated how individuals with a history of heroin addiction perform (compared to healthy controls) in a virtual reality delay discounting task. This novel task adds to established measures of delay discounting an assessment of the optimality of decisions, especially in how far decisions are influenced by a general choice bias and/or a reduced sensitivity to the relative value of the two alternative rewards...
May 9, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28473157/co-occurring-attention-deficit-hyperactivity-disorder-symptoms-in-adults-affected-by-heroin-dependence-patients-characteristics-and-treatment-needs
#13
Fabio Lugoboni, Frances Rudnick Levin, Maria Chiara Pieri, Matteo Manfredini, Lorenzo Zamboni, Lorenzo Somaini, Gilberto Gerra, Gruppo InterSert Collaborazione Scientifica Gics
Attention Deficit Hyperactivity Disorder (ADHD) is a risk for substance use disorders. The aim of this study was to investigate the association between adult ADHD symptoms, opioid use disorder, life dysfunction and co-occurring psychiatric symptoms. 1057 heroin dependent patients on opioid substitution treatment participated in the survey. All patients were screened for adult ADHD symptoms using the Adult ADHD Self-Report Scale (ASRS-v1.1). 19.4% of the patients screened positive for concurrent adult ADHD symptoms status and heroin dependence...
April 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28471281/is-a-history-of-sexual-abuse-related-to-poor-sleep-among-former-opioid-addicted-women-with-and-without-methadone-maintenance-treatment
#14
Einat Peles, Shay Hacohen, Anat Sason, Smadar Lamberg, Shaul Schrieber, Miriam Adelson
To study whether poor sleep that is known to characterize methadone maintenance treatment (MMT) patients may be related to their past sexual abuse and/or their treatment modality, we compared perceived sleep indices (Pittsburgh Sleep Quality Index (PSQI); Epworth Sleepiness Scale (ESS)) and depression (21-HAM-D) between women with and without sexual abuse history (Childhood Trauma Questionnaire) in MMT and in a non-MMT ("opioid medication-free") in-patient rehabilitation center (MABAT). Twenty-six sexually abused women in MMT had the worst sleep quality scores (PSQI) (10...
May 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28464942/-getting-out-of-downtown-a-longitudinal-study-of-how-street-entrenched-youth-attempt-to-exit-an-inner-city-drug-scene
#15
Rod Knight, Danya Fast, Kora DeBeck, Jean Shoveller, Will Small
BACKGROUND: Urban drug "scenes" have been identified as important risk environments that shape the health of street-entrenched youth. New knowledge is needed to inform policy and programing interventions to help reduce youths' drug scene involvement and related health risks. The aim of this study was to identify how young people envisioned exiting a local, inner-city drug scene in Vancouver, Canada, as well as the individual, social and structural factors that shaped their experiences...
May 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28458076/a-comparison-of-bone-quality-and-its-determinants-in-young-opioid-dependent-women-with-healthy-control-group
#16
Zenghui Ding, Yanyan Chen, Xi Wang, Xu Zhou, Yang Xu, Zuchang Ma, Yining Sun, Ming Jiang
BACKGROUND: Little is known about bone quality and its determinants in patients with opioid addiction. The goal of this study was to compare bone quality and its determinants in young opioid addicted women with a local group of young healthy women. METHOD: Using cross-sectional design, 104 women (mean age 29.9 yrs, range: 20-40 yrs, SD=7.8) with previous opioid addiction and current methadone substitution (3-30mg, daily) for 1-16 weeks were compared to 117 healthy women (mean age 31...
April 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28454044/unintended-impacts-of-regulatory-changes-to-british-columbia-methadone-maintenance-program-on-addiction-and-hiv-related-outcomes-an-interrupted-time-series-analysis
#17
M Eugenia Socías, Evan Wood, Ryan McNeil, Thomas Kerr, Huiru Dong, Jean Shoveller, Julio Montaner, M-J Milloy
BACKGROUND: In February 2014, several regulatory reforms were introduced to the methadone maintenance treatment (MMT) program in British Columbia, Canada, including a switch to a ten-times more concentrated methadone formulation and restrictions in pharmacy delivery services. We evaluated possible unintended effects of these changes on illicit drug use patterns and HIV treatment outcomes among HIV-positive opioid users. METHODS: Data was drawn from ACCESS, a prospective community-recruited cohort of HIV-positive people who use illicit drugs in Vancouver, Canada...
April 25, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28442370/modulation-of-drug-choice-by-extended-drug-access-and-withdrawal-in-rhesus-monkeys-implications-for-negative-reinforcement-as-a-driver-of-addiction-and-target-for-medications-development
#18
REVIEW
S Stevens Negus, Matthew L Banks
Chronic drug exposure is hypothesized to recruit negative reinforcement processes that increase the magnitude and alter the mechanisms of drug reinforcement. Candidate substrates of negative reinforcement include increased signaling via stress-related neurotransmitters such as corticotropin releasing factor (CRF, acting at CRF receptors) or dynorphin (acting at kappa opioid receptors) and/or decreased signaling via reward-related neurotransmitters such as dopamine. Determinants of drug reinforcement can be examined with choice procedures, in which subjects choose between a drug of interest (e...
April 22, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28428748/resting-state-neuroimaging-and-neuropsychological-findings-in-opioid-use-disorder-during-abstinence-a-review
#19
REVIEW
Hada Fong-Ha Ieong, Zhen Yuan
Dependence to opiates, including illicit heroin and prescription pain killers, and treatment of the opioid use disorder (OUD) have been longstanding problems over the world. Despite intense efforts to scientific investigation and public health care, treatment outcomes have not significantly improved for the past 50 years. One reason behind the continuing use of heroin worldwide despite such efforts is its highly addictive nature. Brain imaging studies over the past two decades have made significant contribution to the understanding of the addictive properties as to be due in part to biological processes, specifically those in the brain structure and function...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28406856/treating-women-who-are-pregnant-and-parenting-for-opioid-use-disorder-and-the-concurrent-care-of-their-infants-and-children-literature-review-to-support-national-guidance
#20
Stacey L Klaman, Krystyna Isaacs, Anne Leopold, Joseph Perpich, Susan Hayashi, Jeff Vender, Melinda Campopiano, Hendrée E Jones
OBJECTIVES: The prevalence of opioid use disorder (OUD) during pregnancy is increasing. Practical recommendations will help providers treat pregnant women with OUD and reduce potentially negative health consequences for mother, fetus, and child. This article summarizes the literature review conducted using the RAND/University of California, Los Angeles Appropriateness Method project completed by the US Department of Health and Human Services Substance Abuse and Mental Health Services Administration to obtain current evidence on treatment approaches for pregnant and parenting women with OUD and their infants and children...
May 2017: Journal of Addiction Medicine
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