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https://www.readbyqxmd.com/read/29671504/buprenorphine-therapy-for-opioid-use-disorder
#1
Roger Zoorob, Alicia Kowalchuk, Maria Mejia de Grubb
Opioid misuse, including the use of heroin and the overprescribing, misuse, and diversion of opioid pain medications, has reached epidemic proportions in the United States. As a result, there has been a dramatic increase in opioid use disorder and associated overdoses and deaths. Addiction is a chronic brain disease with a genetic component that affects motivation, inhibition, and cognition. Patient characteristics associated with successful buprenorphine maintenance treatment include stable or controlled medical or psychiatric comorbidities and a safe, substance-free environment...
March 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29670549/educational-and-behavioral-counseling-in-a-methadone-maintenance-treatment-program-in-china-a-randomized-controlled-trial
#2
Pulin Liu, Ranran Song, Yao Zhang, Cheng Liu, Bingxi Cai, Xuebing Liu, Jiaoyuan Li, Xueqin Chen, Juntao Ke, Jiao Lou, Wei Chen, Beibei Zhu, Li Zou, Yang Yang, Ying Zhu, Yajie Gong, Rong Zhong, Xiaoping Miao
Introduction: Methadone maintenance treatment (MMT) programs have been rapidly scaled up nationwide in China in recent years, and psychosocial intervention measures, including counseling, were recommended for improving the outcomes of MMT. However, the effectiveness of counseling in MMT programs remains controversial. This study investigated the efficacy of educational and behavioral counseling (EBC) mode in an MMT program in China. Methods: A total of 125 eligible participants were randomized to EBC or a control group...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29657696/comparing-effectiveness-of-mindfulness-based-relapse-prevention-with-treatment-as-usual-on-impulsivity-and-relapse-for-methadone-treated-patients-a-randomized-clinical-trial
#3
Mehdi Yaghubi, Fatemeh Zargar, Hossein Akbari
Background: Impulsivity is one of the causes of relapse that can affect treatment outcomes. Studies have shown that addiction treatments can reduce impulsivity in drug-dependent individuals. Studies also have suggested that mindfulness is associated with impulsivity. However, no study has investigated the effectiveness of the mindfulness-based intervention on impulsivity in opioid-dependent individuals. This study aimed to compare the effectiveness of mindfulness-based relapse prevention (MBRP) with treatment as usual (TAU) in terms of impulsivity and relapse for methadone-treated patients...
July 2017: Addiction & Health
https://www.readbyqxmd.com/read/29657695/effectiveness-of-transactional-analysis-group-therapy-on-addiction-intensity-of-woman-patients-treated-with-methadone
#4
Niloofar Etemadi-Chardah, Bahman Matinpour, Rasoul Heshmati
Background: Addiction brings about severe and profound physical, psychological and social damages such as divorce, crime, and unemployment. The present study was to investigate the effectiveness of transactional analysis (TA) therapy on addiction intensity of woman patients treated with methadone. Methods: The research design was quasi-experimental with a pretest-posttest and a control group. The statistical population consisted of all the addicted women who referred to any drug rehabilitation center of Tehran, Iran, in 2016...
July 2017: Addiction & Health
https://www.readbyqxmd.com/read/29649094/methadone-maintenance-treatment-a-15-year-retrospective-study-in-split-dalmatia-county-croatia
#5
Davorka Sutlovic, Zeljko Kljucevic, Livia Sliskovic, Helena Susnjar, Ivo Viskovic, Marija Definis-Gojanovic
BACKGROUND: The aim of this retrospective study is to use existing epidemiological data on patients in methadone maintenance treatment in Split Dalmatia County from 2001 to 2015 in order to evaluate the substitution treatment system and policy of opiate addicts treatment, the epidemiological trend, and risk of overdose mortality. In addition, we would like to highlight the problem of poor control of methadone therapy, and thus the possibility of selling methadone. The result is a greater number of deaths caused by methadone in people who were not in methadone therapy...
April 11, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29623562/decline-in-buprenorphine-naloxone-prescriptions-in-a-state-medicaid-population-following-formulary-conversion-from-suboxone-to-bunavail
#6
Richard Soper, Sireesh Appajosyula, Christina Deximo
INTRODUCTION: A large, statewide, fee-for-service Medicaid plan recently (October 2015) executed a complete switch from sublingual buprenorphine-naloxone [(SLBN), Suboxone® ] to buccal buprenorphine-naloxone [(BBN), Bunavail® ] on its preferred drug formulary. This complete formulary switch provided an opportunity to assess dynamic changes in prescribing patterns, patient/physician acceptance, and indices of potential misuse/diversion. METHODS: For the period January 1, 2015 through December 31, 2016, two datasets were analyzed: prescriptions and associated costs for buprenorphine-naloxone (BN) products and urine toxicology test results for patients in the Medicaid plan...
April 6, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29616150/methadone-treatment-of-opiate-addiction-a-systematic-review-of-comparative-studies
#7
REVIEW
Shahid Ali, Barira Tahir, Shagufta Jabeen, Madeeha Malik
Opiate misuse is a chronic relapsing disease that has become an epidemic in the United States. Methadone is the mainstay of treatment for opiate addiction and has been researched widely. Recently, new avenues of treatment have been researched and developed. The objective of this review is to study methadone in comparison to other pharmacological options available or being considered for opiate addiction treatment through a methodical search and review of evidence provided by recent clinical trials conducted in this regard...
July 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29606226/a-pilot-study-of-a-smartphone-application-supporting-recovery-from-drug-addiction
#8
Di Liang, Hui Han, Jiang Du, Min Zhao, Yih-Ing Hser
BACKGROUND: Mobile health (mHealth) technologies have the potential to facilitate self-monitoring and self-management for individuals with substance use disorders (SUD). S-Health is a bilingual smartphone application based on cognitive behavioral principles and is designed to support recovery from drug addiction by trigger recognition so as to allow practice in-the-moment coping to prevent relapse. METHOD: For this pilot randomized controlled study, 75 participants were recruited from methadone maintenance treatment clinics and the social worker consortium in Shanghai, China...
May 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29604525/factors-associated-with-discontinuation-of-methadone-maintenance-therapy-mmt-among-persons-who-use-alcohol-in-vancouver-canada
#9
Jan Klimas, Ekaterina Nosova, Eugenia Socías, Seonaid Nolan, Rupinder Brar, Kanna Hayashi, M-J Milloy, Thomas Kerr, Evan Wood
BACKGROUND: We sought to examine the factors associated with discontinuation of MMT among persons on methadone who use alcohol. METHODS: We evaluated the impact of drug-related and other factors on discontinuation of MMT among persons enrolled in MMT and who reported any use of alcohol versus those who were enrolled in two community-recruited prospective cohorts of people who use illicit drugs (PWUD). Extended Cox models with time-dependent variables identified factors independently associated with time to first MMT discontinuation...
March 23, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29595995/barriers-and-facilitators-of-breastfeeding-reported-by-postpartum-women-in-methadone-maintenance-therapy
#10
Jennifer Hicks, Elizabeth Morse, David K Wyant
INTRODUCTION: This study utilized a cross-sectional qualitative and quantitative interview-based survey to capture the infant feeding practices and barriers to exclusive breastfeeding for women in methadone maintenance therapy. Participants were recruited from an opioid dependence treatment center in an urban setting in the Southeastern United States. MATERIALS AND METHODS: A convenience sample of women in treatment (n = 30) were interviewed using an adapted instrument designed to capture decisions and intentions to formula feed or breastfeed; support from friends and family; hospital experience; support from healthcare personnel; and maternal knowledge of breastfeeding while taking methadone...
March 29, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29575801/drug-abuse-screening-with-exhaled-breath-and-oral-fluid-in-adults-with-substance-use-disorder
#11
Michel Arvidsson, Shahid Ullah, Johan Franck, Marja-Liisa Dahl, Olof Beck
In the treatment of substance use disorder regular laboratory-based testing has the dual purpose of monitoring compliance to the prescribed medication and the abstention from medically non-motivated substances (i.e. drug abuse screening). The principal specimen for testing is urine, but collection of urine has some disadvantages, e.g. being more time-consuming and more intrusive compared to other matrices, and there is also the risk of adulteration. This project aims to compare exhaled breath and oral fluid as alternative matrices for drug abuse screening in patients with substance use disorder...
March 25, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29569392/factors-affecting-the-dose-of-methadone-among-patients-receiving-methadone-maintenance-therapy-in-taiwan
#12
Dian-Jeng Li, Kuan-Shang Chung, Hung-Chi Wu, Chih-Yao Hsu, Cheng-Fang Yen
BACKGROUND: Methadone maintenance treatment (MMT) has been shown to be an effective therapeutic strategy for opioid users. This study aimed to investigate the predictive effect of clinically predominant sleep disturbance (CPSD) on the dose of methadone among opiate users receiving MMT during a follow-up period of 6 years in Taiwan. METHODS: This retrospective study included 1,290 individuals with opioid dependence who visited our MMT clinic for the first time. Generalized estimating equations were used to analyze the effect of CPSD on the daily dose of methadone by controlling for the effects of demographic and MMT characteristics...
March 23, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29556689/-compartment-syndrome-of-the-forearm-after-intra-arterial-self-injection-with-a-mixture-of-methadone-flunitrazepam-saliva-and-water
#13
S J M Kamphuis, A R Jandali, F J Jung, J Sproedt
A drug-addicted patient injected himself intra-arterially with a mixture of methadone, flunitrazepam, saliva and water. The resulting compartment syndrome could be treated by fasciotomy and multiple debridement, with which a major amputation could be prevented. The course of the treatment and the resulting functional results are described, as well as a brief overview of the literature and a treatment proposal for similar cases.
March 19, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29544869/criminal-justice-continuum-for-opioid-users-at-risk-of-overdose
#14
Lauren Brinkley-Rubinstein, Nickolas Zaller, Sarah Martino, David H Cloud, Erin McCauley, Andrew Heise, David Seal
The United States (US) is in the midst of an epidemic of opioid use; however, overdose mortality disproportionately affects certain subgroups. For example, more than half of state prisoners and approximately two-thirds of county jail detainees report issues with substance use. Overdose is one of the leading causes of mortality among individuals released from correctional settings. Even though the criminal justice (CJ) system interacts with a disproportionately high number of individuals at risk of opioid use and overdose, few CJ agencies screen for opioid use disorder (OUD)...
February 24, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29509558/transferring-patients-from-methadone-to-buprenorphine-the-feasibility-and-evaluation-of-practice-guidelines
#15
Nicholas Lintzeris, Lauren A Monds, Consuelo Rivas, Stefanie Leung, Adrian Dunlop, David Newcombe, Carina Walters, Susanna Galea, Nancy White, Mark Montebello, Apo Demirkol, Nicola Swanson, Robert Ali
INTRODUCTION AND AIMS: Transfer from methadone to buprenorphine is problematic for many opioid-dependent patients, with limited documented evidence or practical clinical guidance, particularly for the range of methadone doses routinely prescribed for most patients (>50 mg). This study aimed to implement and evaluate recent national Australian guidelines for transferring patients from methadone to buprenorphine. DESIGN AND METHODS: A multisite prospective cohort study...
March 5, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29478095/-the-pen-is-mightier-than-the-sword-suicidal-trans-orbital-intracranial-penetrating-injury-from-a-pencil
#16
Danica Cvetković, Vladimir Živković, Irina Damjanjuk, Slobodan Nikolić
A 40-year-old drug addict, who was being treated with methadone and occupational therapy, committed suicide by striking a wooden pencil into his right eye socket. While still conscious, he hit his head hard against a table, jamming the pencil even deeper into his head. The autopsy showed that the pencil missed the globe and lodged in the inner part of the right eye socket. It pierced the orbital part of the right ethmoid bone, the right ethmoid cells, and the right superior nasal concha, then passed through the body of the sphenoid bone and the clivus of the occipital bone before stopping in the brain tissue...
February 24, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29471921/concurrent-drug-injection-during-opioid-agonist-treatment-among-people-who-inject-drugs-in-ukraine
#17
Iuliia Makarenko, Alyona Mazhnaya, Ruthanne Marcus, Iryna Pykalo, Lynn Madden, Sergii Filippovich, Sergii Dvoriak, Frederick L Altice
Ongoing drug use during opioid agonist treatment (OAT) negatively affects treatment and health outcomes, and increases treatment dropout. This study aimed to examine correlates of concurrent illicit drug use among OAT patients in Ukraine. A random sample of 434 patients currently on OAT receiving buprenorphine (BMT) or methadone maintenance treatment (MMT) from five cities in Ukraine were assessed for factors associated with self-reported concurrent illicit drug use during OAT using a multivariable logistic regression...
April 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29465008/genetic-variations-in-genes-of-the-stress-response-pathway-are-associated-with-prolonged-abstinence-from-heroin
#18
Orna Levran, Einat Peles, Matthew Randesi, Joel Correa da Rosa, Pei-Hong Shen, John Rotrosen, Miriam Adelson, Mary Jeanne Kreek
AIM: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. METHODS: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). RESULTS: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment...
February 21, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29461932/clinical-outcomes-from-a-10-week-follow-up-psychoeducational-programme-for-dual-diagnosis
#19
J Chilton, D Crone, P J Tyson
BACKGROUND: Dual diagnosis covers a broad spectrum of mental health and substance misuse conditions occurring concurrently (NICE, 2016). Its manifestation is complex and as such, the disorder is recognized as influencing adherence to prescribed medication, service engagement and has a worse prognosis than substance use and mental health conditions occurring independently. AIMS: To determine the effectiveness of psycho-educational group therapy on a sample of dual diagnosis patients...
February 20, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29457668/the-relationships-between-depression-neuroticism-and-attitudes-nda-model-in-heroin-abusers-in-taiwan
#20
Kun-Hua Lee, Cheng-Fang Yen
BACKGROUND AND OBJECTIVES: Heroin use is a severe problem worldwide. To develop more effective treatments for heroin abusers, a comprehensive psychosocial model of heroin use should be established and examined. We created and assessed a neuroticism, depression, attitudes, and heroin addiction (NDA) model. METHODS: In this cross-sectional study, 234 patients undergoing methadone replacement treatment were recruited from psychiatric clinics. We used Structural Equation Modeling (SEM) to assess all for neuroticism, depression, and a positive outcome expectancy (POE) (attitudes)...
February 19, 2018: American Journal on Addictions
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