Kaka Renaldi, Marcellus Simadibrata, Nur Rahadiani, Diah Rini Handjari, Alida Roswita Harahap, Kuntjoro Harimurti, Nasrul Zubir, Lianda Siregar, Imelda Maria Loho, Evlina Suzanna, Bonita Prawirodihardjo, Heriawaty Hidajat, Budi Widodo, Alphania Rahniayu, Renaningtyas Tambun, Andy William, Dadang Makmun
Chronic inflammation is a crucial driver of carcinogenesis in pancreatic ductal adenocarcinoma (PDAC). Several studies have investigated the prognostic significance of cyclooxygenase-2 (COX-2) expression in PDAC patients, obtaining conflicting results. Nuclear factor kappa-B (NF-κB), specificity protein 1 (Sp1), and c-Jun are known as the transcription factors of the COX2 gene. This exploratory observational study investigated the association of the NF-κB, COX-2, Sp1, and c-Jun expressions with patient survival in PDAC...
March 25, 2023: Pathophysiology: the Official Journal of the International Society for Pathophysiology