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https://www.readbyqxmd.com/read/29662201/differential-glucose-requirement-in-skin-homeostasis-and-injury-identifies-a-therapeutic-target-for-psoriasis
#1
Zhuzhen Zhang, Zhenzhen Zi, Eunice E Lee, Jiawei Zhao, Diana C Contreras, Andrew P South, E Dale Abel, Benjamin F Chong, Travis Vandergriff, Gregory A Hosler, Philipp E Scherer, Marcel Mettlen, Jeffrey C Rathmell, Ralph J DeBerardinis, Richard C Wang
Proliferating cells, compared with quiescent cells, are more dependent on glucose for their growth. Although glucose transport in keratinocytes is mediated largely by the Glut1 facilitative transporter, we found that keratinocyte-specific ablation of Glut1 did not compromise mouse skin development and homeostasis. Ex vivo metabolic profiling revealed altered sphingolipid, hexose, amino acid, and nucleotide metabolism in Glut1-deficient keratinocytes, thus suggesting metabolic adaptation. However, cultured Glut1-deficient keratinocytes displayed metabolic and oxidative stress and impaired proliferation...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29658378/improvement-of-depressive-symptoms-in-patients-with-moderate-to-severe-psoriasis-treated-with-ustekinumab-an-open-label-trial-validated-using-beck-depression-inventory-hamilton-depression-rating-scale-measures-and-18-fluorodeoxyglucose-fdg-positron-emission
#2
Seong-Jang Kim, Min-Young Park, Kyoungjune Pak, Junhee Han, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: Psoriasis is a chronic skin disease associated with psychiatric co-morbidities, especially depression. Early detection of psychological vulnerability in patients with psoriasis seems to be of great clinical importance and significantly impacts the quality of life of the patients. OBJECTIVES: We sought to clarify the association between psoriasis and depressive symptoms in patients with moderate to severe psoriasis, and to determine the risk factors for depressive symptoms and analyse the effect of ustekinumab on the symptoms...
April 16, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29605673/high-fat-diet-exacerbates-early-psoriatic-skin-inflammation-independent-of-obesity-saturated-fatty-acids-as-key-players
#3
Diana Herbert, Sandra Franz, Yulia Popkova, Ulf Anderegg, Jürgen Schiller, Katharina Schwede, Axel Lorz, Jan C Simon, Anja Saalbach
In obesity, hypertrophic adipocytes secret high amounts of adipocytokines resulting in low-grade inflammation- amplified by infiltrating pro-inflammatory macrophages, oxidative stress, hypoxia and lipolysis. It is known, that these chronic pro-inflammatory conditions support the development of type II diabetes and cardio vascular diseases, while mechanisms of obesity-related exacerbation of inflammatory skin disorders like psoriasis are unclear. In this study, we uncover nutritional saturated fatty acids (SFAs) as major risk factors for the amplification of skin inflammation, independent of obesity-related parameters, like fat mass extension, adipocytokines and glucose homeostasis...
March 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29599672/the-effect-of-subcutaneous-methotrexate-on-markers-of-metabolic-syndrome-in-psoriatic-patients-preliminary-report
#4
Agnieszka Owczarczyk-Saczonek, Marek Drozdowski, Agata Maciejewska-Radomska, Dariusz Choszcz, Waldemar Placek
Introduction: Methotrexate (MTX) has anti-proliferative and anti-inflammatory effects in psoriasis. Moreover, low doses can reduce the risk of developing cardiovascular diseases. It turns out that psoriasis and atherosclerosis have a similar pathogenetic mechanism: the same pro-inflammatory cytokines, Th1 and Th17, are involved in both diseases. Aim: To evaluate the effects of metabolic markers, protective cytokines (interleukin 10 (IL-10), transforming growth factor β (TGF-β)) and a marker of endothelial damage (endocan) in patients with plaque psoriasis...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29548945/ixekizumab-treatment-shows-a-neutral-impact-on-cardiovascular-parameters-in-patients-with-moderate-to-severe-plaque-psoriasis-results-from-uncover-1-2-and-3
#5
Alexander Egeberg, Jashin J Wu, Neil Korman, James A Solomon, Orin Goldblum, Fangyi Zhao, Lotus Mallbris
BACKGROUND: The impact of ixekizumab treatment for psoriasis on cardiovascular-related parameters in patients is unknown. OBJECTIVE: We investigated cardiovascular-related parameters in patients with psoriasis treated with ixekizumab. METHODS: In Phase 3 trials, patients with moderate-to-severe psoriasis were randomized and treated with placebo, ixekizumab, or etanercept during the induction period (Weeks 0-12; UNCOVER-1/-2/-3). At week 12, responders were re-randomized to receive placebo or ixekizumab through the maintenance period (Weeks 12-60; UNCOVER-1/-2)...
March 13, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29535705/immune-mediated-inflammation-promotes-subclinical-atherosclerosis-in-recent-onset-psoriatic-arthritis-patients-without-conventional-cardiovascular-risk-factors
#6
Rodolfo A Kolliker Frers, Vanesa Cosentino, Julia Tau, Eduardo M Kerzberg, Adriana Urdapilleta, Monica Chiocconi, Nora Kogan, Matilde Otero-Losada, Francisco Capani
Studies on the inflammatory burden in recent-onset psoriatic arthritis (PsA) patients without conventional cardiovascular risk factors (CVRFs) are not available. This preliminary study focuses on cardiovascular risk in cutaneous psoriasis (CPs) and recent-onset PsA patients. Blood biochemistry (glucose, cholesterol, uric acid, lipid profile and apolipoprotein B) was analyzed using standard kits. Proatherogenic inflammation markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and endothelial activators monocyte chemoattractant protein-1 (MCP-1) and soluble intercellular adhesion molecule-1 (sICAM-1), were determined by enzyme-linked immunosorbent assay...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29485215/insulin-resistance-in-hidradenitis-suppurativa-a-case-control-study
#7
I Vilanova, J L Hernández, C Mata, C Durán, M T García-Unzueta, V Portilla, P Fuentevilla, A Corrales, M C González-Vela, M A González-Gay, R Blanco, M A González-López
BACKGROUND: The association between chronic inflammatory diseases, such as rheumatoid arthritis and psoriasis, and insulin resistance (IR) has been well established. Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease that affects the apocrine gland-bearing areas of the body. OBJECTIVE: We aimed to determine the prevalence of IR in patients with HS. METHODS: This cross-sectional, case-control study enrolled 137 subjects, 76 patients with HS and 61 age- and gender-matched controls...
February 27, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29483947/metabolic-syndrome-and-the-skin-a-more-than-superficial-association-reviewing-the-association-between-skin-diseases-and-metabolic-syndrome-and-a-clinical-decision-algorithm-for-high-risk-patients
#8
REVIEW
Ellie C Stefanadi, Georgios Dimitrakakis, Christos-Konstantinos Antoniou, Dimitrios Challoumas, Nikita Punjabi, Inetzi Aggeliki Dimitrakaki, Sangeeta Punjabi, Christodoulos I Stefanadis
There is ongoing scientific interest regarding comorbidities associated with the metabolic syndrome (MeTS). MeTS comprises a combination of parameters that predispose individuals to the development of type 2 diabetes and cardiovascular disease (CVD). Three or more of the following criteria are necessary: fasting glucose > 110 mg/dl (5.6 mmol/l), hypertriglyceridemia > 150 mg/dl (1.7 mmol/l), HDL levels < 40 mg/dl (men)/< 50 mg/dl (women), blood pressure > 130/85 mmHg, waist circumference (values for Mediterranean populations > 94 cm (men)/> 89 cm (women)...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29405437/studying-the-effect-of-systemic-and-biological-drugs-on-intima-media-thickness-in-patients-suffering-from-moderate-and-severe-psoriasis
#9
A Martinez-Lopez, G Blasco-Morente, I Perez-Lopez, J Tercedor-Sanchez, S Arias-Santiago
BACKGROUND: Psoriasis has been related to a large number of cardiovascular risk factors such as hypertension, diabetes mellitus and arteriosclerosis. The increased carotid intima-media thickness (IMT) could be considered to be a marker of generalized arteriosclerosis. OBJECTIVE: To assess the effect of systemic and biological drugs on psoriatic patients' carotid IMT. METHODS: A prospective study was performed. We studied 53 patients with moderate and severe psoriasis from our psoriasis dermatological unit, analysing lipid and glucose metabolism and performing a carotid IMT sonography before introduction of systemic and biological drugs...
February 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29390261/metabolic-syndrome-affects-narrow-band-uvb-phototherapy-response-in-patients-with-psoriasis
#10
Wang Rui, Ding Xiangyu, Xie Fang, Gong Long, Yang Yi, Wang Wenjuan, Hao Tian, Zhang Xiaoning, Zhou Yong, Fan Jianfeng, Li Hengjin, Li Chengxin
Psoriasis is a chronic inflammatory skin disease. Metabolic syndrome (MS) is a combination of central obesity, dyslipidemia, glucose intolerance, and elevated blood pressure. Many epidemiological surveys have revealed the association of psoriasis with MS. Narrowband ultraviolet radiation b (NB-UVB) is an effective and widely used treatment for psoriasis. The purpose of this study was to investigate whether the presence of MS in patient with psoriasis affects NB-UVB treatment and whether this syndrome correlates with systemic inflammation...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29334162/prevalence-of-metabolic-syndrome-in-children-with-moderate-to-severe-psoriasis-treated-with-tnf-inhibitors-in-comparison-to-conventional-agents
#11
Nawaf Al Mutairi, Dhuha Alrqobah, Nasser Haji Hussain
Association of childhood psoriasis with metabolic syndrome has not been studied well. TNF-alfa contributes to the inflammation seen in metabolic syndrome, and recently etanercept has shown to reduce the levels of inflammatory markers. Assessment of prevalence of metabolic syndrome in juvenile psoriasis patients in Kuwait. We included 236 patients with moderate to severe psoriasis below 18 years treated for at least 24 weeks with TNF inhibitors (Group A), and equal number of age and sex matched cases treated with conventional medications (Group B)...
January 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29313273/metabolic-syndrome-in-psoriatic-arthritis-the-interplay-with-cutaneous-involvement-evidences-from-literature-and-a-recent-cross-sectional-study
#12
Francesco Caso, Antonio Del Puente, Francesca Oliviero, Rosario Peluso, Nicolò Girolimetto, Paolo Bottiglieri, Francesca Foglia, Carolina Benigno, Marco Tasso, Leonardo Punzi, Raffaele Scarpa, Luisa Costa
The aim of this study was to evaluate the prevalence of MetS and its components and the level of serum uric acid in patients with PsA and in those with PsA sine psoriasis. A secondary aim of the study was to investigate on correlations of MetS in all study population. Consecutive PsA patients underwent assessment of disease activity and metabolic parameters. Blood samples were collected after 12 h of overnight fasting and analyzed for glucose, lipid profile, serum uric acid, and acute-phase reactants. The NCEP-ACT III criteria were used to identify subjects with MetS...
March 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29129905/change-of-oral-to-topical-corticosteroid-therapy-exacerbated-glucose-tolerance-in-a-patient-with-plaque-psoriasis
#13
Yui Hongo, Kenji Ashida, Kenji Ohe, Munechika Enjoji, Miyuki Yamaguchi, Tsuyoshi Kurata, Akiko Emoto, Hiroko Yamanouchi, Satoko Takagi, Hitoe Mori, Nozomi Kawata, Yoshio Hisata, Yuta Sakanishi, Kenichi Izumi, Takashi Sugioka, Keizo Anzai
BACKGROUND Psoriasis is known as the most frequent disease treated by long-term topical steroids. It is also known that patients with thick, chronic plaques require the highest potency topical steroids. However, the treatment is limited to up to four weeks due to risk of systemic absorption. CASE REPORT An 80-year-old man was diagnosed with type 2 diabetes 16 years before, and was being administered insulin combined with alpha glucosidase inhibitor. He was diagnosed with plaque psoriasis and his oral steroid treatment was switched to topical steroid treatment due to lack of improvement and poorly controlled blood glucose level...
November 13, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29068430/systemic-inflammation-oxidative-damage-to-nucleic-acids-and-metabolic-syndrome-in-the-pathogenesis-of-psoriasis
#14
Lenka Borska, Jan Kremlacek, Ctirad Andrys, Jan Krejsek, Kvetoslava Hamakova, Pavel Borsky, Vladimir Palicka, Vit Rehacek, Andrea Malkova, Zdenek Fiala
In the pathogenesis of psoriasis, systemic inflammation and oxidative stress play mutual roles interrelated with metabolic syndrome (MetS). This study aims to map the selected markers of inflammation (C-reactive protein (CRP)), oxidative damage to nucleic acids (DNA/RNA damage; 8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), and the parameters of MetS (waist circumference, fasting glucose, triglycerides, high-density lipoprotein (HDL) cholesterol, diastolic and systolic blood pressure) in a group of 37 patients with psoriasis (62% of MetS) and in 43 healthy controls (42% of MetS)...
October 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28985599/can-the-skin-make-you-fat-a-role-for-the-skin-in-regulating-adipose-tissue-function-and-whole-body-glucose-and-lipid-homeostasis
#15
REVIEW
Paul W Caton, Elizabeth A Evans, Michael P Philpott, Rosalind F Hannen
Prevalence of obesity and related complications such as type 2 diabetes (T2D) has increased dramatically in recent decades. Metabolic complications of obesity arise in part due to subcutaneous adipose tissue (SAT) dysfunction. However, it is currently unclear why some obese individuals develop insulin resistance and T2D and others do not. In this review, we discuss the role of the skin in regulating SAT function, and whether presence of inflammatory skin diseases such as psoriasis represent a novel risk mechanism mediating development of obesity-related complications...
December 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28904916/prevalence-of-metabolic-syndrome-in-psoriasis-and-levels-of-interleukin-6-and-tumor-necrosis-factor-%C3%AE-in-psoriasis-patients-with-metabolic-syndrome-indian-tertiary-care-hospital-study
#16
Surjit Singh, Sunil Dogra, Nusrat Shafiq, Anil Bhansali, Samir Malhotra
BACKGROUND: Psoriasis is a chronic inflammatory multisystem disease, found to be associated with metabolic syndrome (MS) and increased levels of cytokines. To evaluate the prevalence of MS in psoriasis and to determine the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in psoriasis patients with MS. METHODS: Observational study on 334 psoriasis patients and 230 controls. MS was diagnosed by the presence of three or more criteria of original, revised, and modified National Cholesterol Education Program's Adult Treatment Panel III (NCEP ATP III)...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28721154/obesity-and-inflammation-the-linking-mechanism-and-the-complications
#17
Mohammed S Ellulu, Ismail Patimah, Huzwah Khaza'ai, Asmah Rahmat, Yehia Abed
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28670544/randomized-placebo-control-study-of-metformin-in-psoriasis-patients-with-metabolic-syndrome-systemic-treatment-cohort
#18
Surjit Singh, Anil Bhansali
BACKGROUND: Psoriasis has been found to be associated with obesity, metabolic syndrome (MS), diabetes, and cardiovascular risk factors. Metformin treatment showed improvement in cardiovascular risk factors and hyperinsulinemia. OBJECTIVE: To evaluate the efficacy and safety of metformin in psoriasis patients with MS. MATERIALS AND METHODS: This was a single-center, parallel-group, randomized, open-label study with blinded end point assessment of metformin (1000 mg once daily for 12 weeks; n = 20) and placebo (n = 18) in psoriasis patients with MS...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28498006/serum-ykl-40-as-a-potential-biomarker-of-inflammation-in-psoriasis
#19
Anna Baran, Hanna Myśliwiec, Malgorzata Szterling-Jaworowska, Paulina Kiluk, Magdalena Świderska, Iwona Flisiak
OBJECTIVE: YKL-40 is an inflammatory glycoprotein associated with atherosclerosis, cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. The aim of the study was to assess serum YKL-40 level in psoriasis and elucidate possible associations with disease activity, inflammatory or metabolic parameters and treatment. METHODS: A total of 37 individuals with active plaque-type psoriasis and 15 healthy controls were enrolled...
May 30, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28489810/a-case-report-of-hereditary-neuropathy-with-liability-to-pressure-palsies-accompanied-by-type-2-diabetes-mellitus-and-psoriasis
#20
Jing Li, Bing Niu, Xiaoling Wang, Huaiqiang Hu, Bingzhen Cao
RATIONALE: Hereditary neuropathy with liability to pressure palsy (HNPP) is an episodic, multifocal neuropathy, with a typical clinical presentation of recurrent transient pressure palsies, which is induced by a PMP22 deletion. Another neuropathy caused by a PMP22 duplication is Charcot-Marie-Tooth disease type 1A (CMT1A). PMP22 is a gene coding a protein called peripheral myelin protein 22 (PMP22), which plays an essential role in the formation and maintenance of compact myelin. Coexistence of type 2 diabetes mellitus (T2DM) and CMT1A has been reported in many work, however HNPP patients with T2DM are rare, and comorbidity of HNPP and psoriasis has not been reported previously...
May 2017: Medicine (Baltimore)
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