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https://www.readbyqxmd.com/read/28721154/obesity-and-inflammation-the-linking-mechanism-and-the-complications
#1
Mohammed S Ellulu, Ismail Patimah, Huzwah Khaza'ai, Asmah Rahmat, Yehia Abed
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28670544/randomized-placebo-control-study-of-metformin-in-psoriasis-patients-with-metabolic-syndrome-systemic-treatment-cohort
#2
Surjit Singh, Anil Bhansali
BACKGROUND: Psoriasis has been found to be associated with obesity, metabolic syndrome (MS), diabetes, and cardiovascular risk factors. Metformin treatment showed improvement in cardiovascular risk factors and hyperinsulinemia. OBJECTIVE: To evaluate the efficacy and safety of metformin in psoriasis patients with MS. MATERIALS AND METHODS: This was a single-center, parallel-group, randomized, open-label study with blinded end point assessment of metformin (1000 mg once daily for 12 weeks; n = 20) and placebo (n = 18) in psoriasis patients with MS...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28498006/serum-ykl-40-as-a-potential-biomarker-of-inflammation-in-psoriasis
#3
Anna Baran, Hanna Myśliwiec, Malgorzata Szterling-Jaworowska, Paulina Kiluk, Magdalena Świderska, Iwona Flisiak
OBJECTIVE: YKL-40 is an inflammatory glycoprotein associated with atherosclerosis, cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. The aim of the study was to assess serum YKL-40 level in psoriasis and elucidate possible associations with disease activity, inflammatory or metabolic parameters and treatment. METHODS: A total of 37 individuals with active plaque-type psoriasis and 15 healthy controls were enrolled...
May 30, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28489810/a-case-report-of-hereditary-neuropathy-with-liability-to-pressure-palsies-accompanied-by-type-2-diabetes-mellitus-and-psoriasis
#4
Jing Li, Bing Niu, Xiaoling Wang, Huaiqiang Hu, Bingzhen Cao
RATIONALE: Hereditary neuropathy with liability to pressure palsy (HNPP) is an episodic, multifocal neuropathy, with a typical clinical presentation of recurrent transient pressure palsies, which is induced by a PMP22 deletion. Another neuropathy caused by a PMP22 duplication is Charcot-Marie-Tooth disease type 1A (CMT1A). PMP22 is a gene coding a protein called peripheral myelin protein 22 (PMP22), which plays an essential role in the formation and maintenance of compact myelin. Coexistence of type 2 diabetes mellitus (T2DM) and CMT1A has been reported in many work, however HNPP patients with T2DM are rare, and comorbidity of HNPP and psoriasis has not been reported previously...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421729/effects-of-tnf-%C3%AE-inhibitors-in-patients-with-psoriasis-and-metabolic-syndrome-a-preliminary-study
#5
Giulia Merlo, Emanuele Cozzani, Martina Burlando, Stefano Calvieri, Concetta Potenza, Luca Stingeni, Giorgio Filosa, Monica Pau, Marco Simonacci, Marzia Caproni, Aurora Parodi
BACKGROUND: Psoriasis is an inflammatory disease, that is increasingly being considered as a systemic disorder. Among associated comorbidities, metabolic syndrome plays an important role. The effects of biological therapies on metabolic syndrome is controversial. METHODS: Thirty-one psoriatic patients with metabolic syndrome, eligible to treatment with anti-TNFα agents, were enrolled. Metabolic parameters were measured during 4 subsequent visits, one every 40 to 60 days...
April 19, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28384966/metabolic-syndrome-in-psoriasis-among-urban-south-indians-a-case-control-study-using-sam-ncep-criteria
#6
Banavasi S Girisha, Neetha Thomas
INTRODUCTION: Psoriasis is a chronic inflammatory disease of the skin associated with increased cardiovascular morbidity. Metabolic syndrome is a significant forecaster of cardiovascular events. AIM: To assess the association of metabolic syndrome and its components in patients with psoriasis and to compare it with the age and sex matched control group. MATERIALS AND METHODS: We conducted a hospital based case-control study on 156 adult patients with chronic plaque psoriasis and 156 patients with skin diseases other than psoriasis...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28128076/assessment-of-cardiovascular-risk-factors-in-patients-with-psoriasis
#7
Olivia Komorowska, Michal Bohdan, Aneta Szczerkowska-Dobosz, Dorota Rawicz-Zegrzda, Maria Dudziak, Tomasz Zdrojewski, Marcin Gruchala, Dorota Purzycka-Bohdan, Roman Nowicki
Psoriasis is a chronic inflammatory skin disorder associated with increased cardiovascular risk. Aim of this work was to evaluate the association between psoriasis and chosen cardiovascular risk factors, echocardiographic parameters, and carotid intima-media thickness. A total of 50 patients with psoriasis and 50 controls were enrolled in the study. Psoriasis area severity index was calculated in the study group. Systolic and diastolic blood pressure, body mass index, waist circumference, lipids, fasting glucose, and D-dimer levels were assessed in all patients...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28099469/the-prevalence-of-nonalcoholic-fatty-liver-disease-and-related-metabolic-comorbidities-was-associated-with-age-at-onset-of-moderate-to-severe-plaque-psoriasis-a-cross-sectional-study
#8
Xin Xu, Lina Su, Yunlu Gao, Yangfeng Ding
Nonalcoholic fatty liver disease (NAFLD) has been found to be highly prevalent in psoriatic patients. Adult onset psoriasis could be divided into either early or late onset psoriasis. The associations between NAFLD and related metabolic comorbidities and age at onset of psoriasis have not yet been investigated. Our study was to evaluate the associations between prevalence of NAFLD and related metabolic conditions and early, late, and childhood onset psoriasis. A cross-sectional observational study was conducted on patients with moderate to severe plaque psoriasis...
2017: PloS One
https://www.readbyqxmd.com/read/28050485/metabolic-derangements-in-lichen-planus-a-case-control-study
#9
Bikash Ranjan Kar, Maitreyee Panda, Nibedita Patro
INTRODUCTION: An association between psoriasis and metabolic syndrome has been established in previous studies. Lichen Planus (LP) is also a chronic inflammatory disease morphologically related to psoriasis and few studies have shown association of metabolic derangements in LP. AIM: To study the association of metabolic derangements in LP. MATERIALS AND METHODS: A prospective case control study was undertaken for a period of one year. Age and sex matched patients of LP and other non-inflammatory diseases were taken as cases and controls respectively...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28044372/psoriasis-and-metabolic-syndrome-in-children-current-data
#10
REVIEW
A Pietrzak, E Grywalska, M Walankiewicz, T Lotti, J Roliński, W Myśliński, P Chabros, D Piekarska-Myślińska, K Reich
BACKGROUND: The prevalence of cardiovascular and metabolic disorders in paediatric patients with psoriasis is not well established. AIM: To conduct a meta-analysis of previously published studies dealing with the occurrence of metabolic disorders in children with psoriasis. METHODS: Data from 7 studies with a total of 965 children with psoriasis were analysed using a random effects model. RESULTS: Prevalence of metabolic syndrome (MetS) was significantly higher in patients with psoriasis than in healthy controls (HCs)...
March 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27864821/effect-of-alterations-in-apoptotic-pathway-on-development-of-metabolic-syndrome-in-patients-with-psoriasis-vulgaris
#11
S Korkmaz, H Korkmaz
BACKGROUND: An increase in the incidence of metabolic syndrome (MetS) has been identified in patients with psoriasis. OBJECTIVES: To evaluate the role of changes in expression of apoptosis activators [B-cell lymphoma (Bcl)-2-like protein 4 (BAX), cytochrome c (cytC) and caspase-3 (CASP3)] and apoptosis inhibitors [Bcl-2, survivin, cyclin D1 (CCND1), superoxide dismutase (SOD), catalase 3 (CAT), glutathione synthetase (GS), heat shock protein (Hsp)27, Hsp60, Hsp70 and Hsp90] on development of MetS in patients with psoriasis vulgaris...
November 18, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27864793/serum-fatty-acid-binding-protein-4-is-increased-in-patients-with-psoriasis
#12
A Baran, M Świderska, Joanna Bacharewicz-Szczerbicka, H Myśliwiec, I Flisiak
Psoriasis is associated with metabolic syndrome and cardiovascular disease. Fatty acid-binding proteins (FABP) have been recognized as predictors of these systemic disorders. The aim of this study was to assess correlations between levels of serum heart and adipocyte fatty acid-binding proteins (FABP3, FABP4) and disease severity, indicators of inflammation or metabolic disturbances, and topical treatment in psoriatic patients. Thirty-seven patients with relapse of plaque-type psoriasis and 16 healthy volunteers were recruited...
January 2017: Lipids
https://www.readbyqxmd.com/read/27815622/-cutaneous-manifestations-of-metabolic-syndrome
#13
REVIEW
G Holzer, B Straßegger, B Volc-Platzer
BACKGROUND: Metabolic syndrome (MetS) is a cluster of risk factors which increase the risk of developing cardiovascular diseases and type II diabetes mellitus. High blood pressure, hyperglycemia, dyslipidemia, and central obesity are the main risk factors. While MetS is not a dermatological diagnosis per se, several cutaneous manifestations can serve as a clinical indicator for impending MetS and facilitate an early diagnosis and therapy in order to prevent its long-term sequelae...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27608863/study-of-association-of-atherosclerotic-risk-factors-and-metabolic-syndrome-in-patients-of-psoriasis-at-a-tertiary-care-centre-in-north-india-a-case-control-study
#14
Satish Chand Sharma, Prafulla Kumar Sharma, R K Dudeja
OBJECTIVE: To study the association between psoriasis and atherosclerotic risk factors, including metabolic syndrome. METHODS: Fifty patients with psoriasis and 50 controls were included in the study. Atherosclerotic risk factors were evaluated as per National Cholesterol Education Project Adult Treatment Panel III (NCEP-ATPIII). Metabolic syndrome was diagnosed as per South Asian Modified -National Cholesterol Education Programme's Adult Treatment Panel III (ATP III)...
September 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27498668/efficacy-and-safety-of-dr-michaels%C3%A2-soratinex%C3%A2-product-family-for-the-topical-treatment-of-psoriasis-a-monitored-status-study
#15
K França, F Novotny, J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, U Wollina, M Tirant, M G Roccia, T Lotti
The aim of the study was to investigate the efficacy and safety of Michaels® (Soratinex®) remedies in patients suffering from chronic plaque psoriasis in a Czech population. Seventy-five (34 female/41 male) patients, aged 18-72 years old (mean age: 38.5 years) with mild to severe plaque psoriasis participated in the study. The products, including cleansing gel, ointment and skin conditioner, containing fruit acid complex, herbal oils and emulsifiers, were used twice daily and in the same manner for all the skin lesions...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27411805/considerations-for-systemic-treatment-of-psoriasis-in-obese-patients
#16
REVIEW
Paolo Gisondi, Micol Del Giglio, Giampiero Girolomoni
Psoriasis is an immune-mediated inflammatory skin disease frequently associated with metabolic disorders, including diabetes, dyslipidaemia and metabolic syndrome. Moreover, a growing number of studies confirm the association between psoriasis and obesity. It has been found that obesity, as measured by body mass index >30 kg/m(2), can double the risk of incident psoriasis. A positive correlation between different measures of adiposity and the severity of psoriasis has also been reported. Epidemiologic studies have also provided robust evidence confirming the association between obesity and psoriatic arthritis...
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27402434/the-australasian-psoriasis-collaboration-view-on-methotrexate-for-psoriasis-in-the-australasian-setting
#17
REVIEW
Marius Rademaker, Monisha Gupta, Megan Andrews, Katherine Armour, Chris Baker, Peter Foley, Kurt Gebauer, Jacob George, Diana Rubel, John Sullivan
The Australasian Psoriasis Collaboration reviewed methotrexate (MTX) in the management of psoriasis in the Australian and New Zealand setting. The following comments are based on expert opinion and a literature review. Low-dose MTX (< 0.4 mg/kg per week) has a slow onset of action and has moderate to good efficacy, together with an acceptable safety profile. The mechanism of action is anti-inflammatory, rather than immunosuppressive. For pretreatment, consider testing full blood count (FBC), liver and renal function, non-fasting lipids, hepatitis serology, HbA1c and glucose...
July 12, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27401209/impact-of-elevated-serum-uric-acid-levels-on-systemic-inflammation-in-patients-with-psoriasis
#18
Berna Solak, Bahar Sevimli Dikicier, Teoman Erdem
Patients with psoriasis have increased systemic inflammation and serum uric acid (SUA) levels compared with the general population. However, the role of SUA in modulating inflammation in these patients is not known. We evaluated the associations of SUA with inflammation and psoriasis severity; 199 patients with psoriasis and 54 healthy volunteers were included in the study. Demographic features, Psoriasis Area and Severity Index (PASI) scores, and laboratory data including SUA, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were collected...
July 8, 2016: Angiology
https://www.readbyqxmd.com/read/27322922/crosstalk-between-skin-inflammation-and-adipose-tissue-derived-products-pathogenic-evidence-linking-psoriasis-to-increased-adiposity
#19
REVIEW
Andrea Chiricozzi, Annunziata Raimondo, Serena Lembo, Francesca Fausti, Valentina Dini, Antonio Costanzo, Giuseppe Monfrecola, Nicola Balato, Fabio Ayala, Marco Romanelli, Anna Balato
Psoriasis is a chronic skin disorder associated with several comorbid conditions. In psoriasis pathogenesis, the role of some cytokines, including TNF-α and IL-17, has been elucidated. Beside their pro-inflammatory activity, they may also affect glucose and lipid metabolism, possibly promoting insulin resistance and obesity. On the other hand, adipose tissue, secreting adipokines such as chemerin, visfatin, leptin, and adiponectin, not only regulates glucose and lipid metabolism, and endothelial cell function regulation, but it may contribute to inflammation...
December 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/27279820/presence-of-selected-metabolic-syndrome-components-in-patients-with-psoriasis-vulgaris
#20
Sebastian Uczniak, Zofia A Gerlicz, Magdalena Kozłowska, Andrzej Kaszuba
INTRODUCTION: Recent studies have suggested a strong association between psoriasis and obesity, dyslipidemia, hypertension, resistance to insulin and metabolic syndrome. AIM: To assess the prevalence of selected metabolic syndrome components in patients with psoriasis and the effect of the abnormalities on the disease activity. MATERIAL AND METHODS: Two hundred and forty-six patients diagnosed with psoriasis and 75 healthy individuals as controls were included in the study...
April 2016: Postȩpy Dermatologii i Alergologii
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