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glucose + psoriasis

Satish Chand Sharma, Prafulla Kumar Sharma, R K Dudeja
OBJECTIVE: To study the association between psoriasis and atherosclerotic risk factors, including metabolic syndrome. METHODS: Fifty patients with psoriasis and 50 controls were included in the study. Atherosclerotic risk factors were evaluated as per National Cholesterol Education Project Adult Treatment Panel III (NCEP-ATPIII). Metabolic syndrome was diagnosed as per South Asian Modified -National Cholesterol Education Programme's Adult Treatment Panel III (ATP III)...
September 2015: Journal of the Association of Physicians of India
K França, F Novotny, J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, U Wollina, M Tirant, M G Roccia, T Lotti
The aim of the study was to investigate the efficacy and safety of Michaels® (Soratinex®) remedies in patients suffering from chronic plaque psoriasis in a Czech population. Seventy-five (34 female/41 male) patients, aged 18-72 years old (mean age: 38.5 years) with mild to severe plaque psoriasis participated in the study. The products, including cleansing gel, ointment and skin conditioner, containing fruit acid complex, herbal oils and emulsifiers, were used twice daily and in the same manner for all the skin lesions...
April 2016: Journal of Biological Regulators and Homeostatic Agents
Paolo Gisondi, Micol Del Giglio, Giampiero Girolomoni
Psoriasis is an immune-mediated inflammatory skin disease frequently associated with metabolic disorders, including diabetes, dyslipidaemia and metabolic syndrome. Moreover, a growing number of studies confirm the association between psoriasis and obesity. It has been found that obesity, as measured by body mass index >30 kg/m(2), can double the risk of incident psoriasis. A positive correlation between different measures of adiposity and the severity of psoriasis has also been reported. Epidemiologic studies have also provided robust evidence confirming the association between obesity and psoriatic arthritis...
July 13, 2016: American Journal of Clinical Dermatology
Marius Rademaker, Monisha Gupta, Megan Andrews, Katherine Armour, Chris Baker, Peter Foley, Kurt Gebauer, Jacob George, Diana Rubel, John Sullivan
The Australasian Psoriasis Collaboration reviewed methotrexate (MTX) in the management of psoriasis in the Australian and New Zealand setting. The following comments are based on expert opinion and a literature review. Low-dose MTX (< 0.4 mg/kg per week) has a slow onset of action and has moderate to good efficacy, together with an acceptable safety profile. The mechanism of action is anti-inflammatory, rather than immunosuppressive. For pretreatment, consider testing full blood count (FBC), liver and renal function, non-fasting lipids, hepatitis serology, HbA1c and glucose...
July 12, 2016: Australasian Journal of Dermatology
Berna Solak, Bahar Sevimli Dikicier, Teoman Erdem
Patients with psoriasis have increased systemic inflammation and serum uric acid (SUA) levels compared with the general population. However, the role of SUA in modulating inflammation in these patients is not known. We evaluated the associations of SUA with inflammation and psoriasis severity; 199 patients with psoriasis and 54 healthy volunteers were included in the study. Demographic features, Psoriasis Area and Severity Index (PASI) scores, and laboratory data including SUA, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were collected...
July 8, 2016: Angiology
Andrea Chiricozzi, Annunziata Raimondo, Serena Lembo, Francesca Fausti, Valentina Dini, Antonio Costanzo, Giuseppe Monfrecola, Nicola Balato, Fabio Ayala, Marco Romanelli, Anna Balato
INTRODUCTION: Psoriasis is a chronic skin disorder associated with several comorbid conditions. In psoriasis pathogenesis, the role of some cytokines, including TNF-α and IL-17, has been elucidated. Beside their pro-inflammatory activity, they may also affect glucose and lipid metabolism, possibly promoting insulin resistance and obesity. On the other hand, adipose tissue, secreting adipokines such as chemerin, visfatin, leptin, and adiponectin, not only regulates glucose and lipid metabolism, and endothelial cell function regulation, but it may contribute to inflammation...
June 20, 2016: Expert Review of Clinical Immunology
Sebastian Uczniak, Zofia A Gerlicz, Magdalena Kozłowska, Andrzej Kaszuba
INTRODUCTION: Recent studies have suggested a strong association between psoriasis and obesity, dyslipidemia, hypertension, resistance to insulin and metabolic syndrome. AIM: To assess the prevalence of selected metabolic syndrome components in patients with psoriasis and the effect of the abnormalities on the disease activity. MATERIAL AND METHODS: Two hundred and forty-six patients diagnosed with psoriasis and 75 healthy individuals as controls were included in the study...
April 2016: Postȩpy Dermatologii i Alergologii
S Coimbra, C Catarino, A Santos-Silva
Psoriasis is a chronic inflammatory skin disease, often associated with overweight/obesity. The adipose tissue is a complex organ that secretes several adipokines, involved in the regulation of some metabolic processes, such as lipid metabolism, glucose homeostasis, angiogenesis, blood pressure and inflammation. In obesity, the distribution and function of adipose tissue, and the adipokine profile are altered. The unbalanced production of pro- and anti-inflammatory adipokines in obesity, contributes to the development of a chronic low-grade inflammation state, which seems to favour worsening of psoriasis lesion and a poorer response to treatment...
May 27, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Kristin Stelzner, Diana Herbert, Yulia Popkova, Axel Lorz, Jürgen Schiller, Martin Gericke, Nora Klöting, Matthias Blüher, Sandra Franz, Jan C Simon, Anja Saalbach
Obesity is associated with body fat gain and impaired glucose metabolism. Here, we identified both body fat gain in obesity and impaired glucose metabolism as two independent risk factors for increased serum levels of free fatty acids (FFAs). Since obesity is associated with increased and/or delayed resolution of inflammation observed in various chronic inflammatory diseases such as psoriasis, we investigated the impact of FFAs on human monocyte-derived and mouse bone marrow-derived dendritic cell (DCs) functions relevant for the pathogenesis of chronic inflammation...
August 2016: European Journal of Immunology
Young-Sun Lee, Hee-Sook Jun
Glucagon-like peptide-1 (GLP-1) is an incretin hormone mainly secreted from intestinal L cells in response to nutrient ingestion. GLP-1 has beneficial effects for glucose homeostasis by stimulating insulin secretion from pancreatic beta-cells, delaying gastric emptying, decreasing plasma glucagon, reducing food intake, and stimulating glucose disposal. Therefore, GLP-1-based therapies such as GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase-4, which is a GLP-1 inactivating enzyme, have been developed for treatment of type 2 diabetes...
2016: Mediators of Inflammation
Gökhan Okan, Adile Merve Baki, Eda Yorulmaz, Semra Doğru-Abbasoğlu, Pervin Vural
PURPOSE: Psoriasis is an immune-mediated skin disease characterised by accentuated keratinocyte proliferation, hyperkeratinisation, leukocyte and T-lymphocyte chemotaxis, and neoangiogenesis. Chronic inflammation, imbalance between pro- and anti-inflammatory cytokines, and many angiogenic mediators has been implicated in the disease etiopathogenesis. The aim of this study was to investigate whether psoriasis is related to fibroblast growth factor 23 (FGF23) and placental growth factor (PLGF) - mediators related to insulin resistance (IR), metabolic syndrome, and atherosclerosis...
2016: Annals of Clinical and Laboratory Science
Udayakumar Praveenkumar, Satyaki Ganguly, Lopamudra Ray, Sunil Kumar Nanda, Sheela Kuruvila
INTRODUCTION: Previous studies indicate a higher prevalence of metabolic syndrome in psoriatic patients. This study aimed to investigate the association of metabolic syndrome and its components with psoriasis. It also studied the relation between presence of metabolic syndrome and disease duration in psoriasis patients. MATERIALS AND METHODS: This was a hospital-based, case-control study conducted with 30 clinically diagnosed patients of chronic plaque psoriasis and 30 age- and sex-matched control subjects...
February 2016: Journal of Clinical and Diagnostic Research: JCDR
Angelo A Izzo, Sung Hoon-Kim, Rajan Radhakrishnan, Elizabeth M Williamson
Systematic reviews and meta-analyses represent the uppermost ladders in the hierarchy of evidence. Systematic reviews/meta-analyses suggest preliminary or satisfactory clinical evidence for agnus castus (Vitex agnus castus) for premenstrual complaints, flaxseed (Linum usitatissimum) for hypertension, feverfew (Tanacetum partenium) for migraine prevention, ginger (Zingiber officinalis) for pregnancy-induced nausea, ginseng (Panax ginseng) for improving fasting glucose levels as well as phytoestrogens and St John's wort (Hypericum perforatum) for the relief of some symptoms in menopause...
May 2016: Phytotherapy Research: PTR
Melis Coban, Levent Tasli, Sebahat Turgut, Seyma Özkan, Melek Tunç Ata, Fulya Akın
BACKGROUND: Systemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with the development of psoriasis. OBJECTIVE: The purpose of this study was to determine the changes in adipokine levels, insulin resistance, hypertension, and dyslipidemia over a 12-week period. METHODS: The study comprised 35 psoriasis patients and 50 controls...
February 2016: Annals of Dermatology
Yugal K Sharma, Naren Prakash, Aayush Gupta
BACKGROUND: The inexorable inflammation in patients of psoriasis predisposes to various disorders, notably, a cluster of cardiovascular and metabolic abnormalities christened 'metabolic syndrome'. AIM: To assess the prevalence of metabolic syndrome and its correlation with the severity and duration of psoriasis. METHODS: One hundred psoriasis patients and 100 age-and-sex matched controls were included, whose waist circumference and blood pressure were measured; fasting serum cholesterol, triglycerides and glucose levels quantified; disease severity assessed and metabolic syndrome defined separately by two globally accepted criteria...
April 2016: Diabetes & Metabolic Syndrome
Wynnis L Tom, Martin P Playford, Shehla Admani, Balaji Natarajan, Aditya A Joshi, Lawrence F Eichenfield, Nehal N Mehta
Psoriasis is associated with increased cardiovascular disease in adults, but the risk profile of children with psoriasis remains to be fully characterized. We measured lipoprotein composition and function in 44 patients with pediatric psoriasis and 44 age- and sex-matched healthy controls, using nuclear magnetic resonance spectroscopy and a validated ex vivo assay of high-density lipoprotein cholesterol efflux capacity. The mean age of the patients was 13 years and the population was ethnically diverse. Children with psoriasis had higher waist-to-hip ratios (0...
January 2016: Journal of Investigative Dermatology
Salam Itani, Asma Arabi, Dana Harb, Diana Hamzeh, Abdul-Ghani Kibbi
BACKGROUND: Psoriasis is a chronic inflammatory disease that affects not only the skin but also other organs as well. Genetic factors play an important role in individual predisposition. Lately, a positive association has been confirmed between psoriasis and metabolic syndrome (MBS), in western as well as in Middle Eastern countries. AIM: Assess the prevalence of MBS in Lebanese patients with psoriasis and the differential effect according to types and disease severity...
April 2016: International Journal of Dermatology
Wynnis L Tom, Martin P Playford, Shehla Admani, Balaji Natarajan, Aditya A Joshi, Lawrence F Eichenfield, Nehal N Mehta
Psoriasis is associated with increased cardiovascular disease (CVD) in adults, but the risk profile of children with psoriasis remains to be fully characterized. We measured lipoprotein composition and function in 44 pediatric psoriasis patients and 44 age- and sex-matched healthy controls, using NMR spectroscopy and a validated ex vivo assay of high density lipoprotein (HDL) cholesterol efflux capacity (CEC). Mean age was 13.0 years and the population was ethnically diverse. Children with psoriasis had higher waist-hip ratios (0...
September 30, 2015: Journal of Investigative Dermatology
Luigi Barrea, Paolo Emidio Macchia, Giovanni Tarantino, Carolina Di Somma, Elena Pane, Nicola Balato, Maddalena Napolitano, Annamaria Colao, Silvia Savastano
BACKGROUND: Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association between diet and psoriasis. The 7-day food records is considered the "gold standard" of self-administered food frequency questionnaires. In this study, we evaluated the differences in the dietary intake, anthropometric measurements and cardio-metabolic risk profile in a group of psoriatic patients compared with an age and Body Mass Index (BMI)-matched control group...
2015: Journal of Translational Medicine
Jillian H Swary, Erik J Stratman
BACKGROUND/OBJECTIVES: Comorbidities and risk factors are associated with pediatric psoriasis. It is unknown whether pediatricians and dermatologists ask about, record, or counsel on pediatric psoriasis risk factors and comorbidities. The aim of our study was to assess the rate at which pediatricians and dermatologists inquire about, counsel on, and document pediatric psoriasis risk factors and comorbidities in a stable population. METHODS: This was a retrospective chart review from 2011 to 2013 in a large, rural multidisciplinary clinic, the Marshfield Epidemiologic Study Area...
November 2015: Pediatric Dermatology
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