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Pain paeds

Fayez Hanna, Ajay Prakash, Ebony Allan, Alhossain A Khalafallah
A 70-year-old man presented with left loin pain without urinary symptoms. Initial investigations with CT showed enlarged para-aortic, mediastinal lymph nodes, right-side renal mass and enlarged prostate. A prostatic-specific antigen (PSA) was alarmingly high at 4750 μg/L (normal <4.0 μg/L). Further investigations included positron emission tomography (PET); both prostate-specific membrane antigen and 18-fluorodeoxyglucose as well as bone scan and bone marrow examination confirmed dual malignancies with B-cell non-Hodgkin's lymphoma (B-NHL) and wide spread metastatic prostatic adenocarcinoma (PA) to the skull, spine, pelvis, liver and lungs...
March 16, 2018: BMJ Case Reports
Sergio Barroso Rosa, Zaid Bahho, Kenji Doma, Kaushik Hazratwala, Peter McEwen, Varaguna Manoharan, Brent Matthews, Matthew Wilkinson
INTRODUCTION: Patella alta (PA) is one of the primary correctable risk factors for patellofemoral instability (PFI). Both an accurate diagnosis of PA and a clinically relevant target for correction are necessary for optimal treatment. An ideal test for PA should relate the position of the patella to the femur rather than tibia, should do so with the quadriceps contracted and the patellar tendon under tension and should have good sensitivity and specificity. None of the currently used radiographic tests PA meet these criteria, most of which are based on the position of the patella relative to the tibia with diagnostic cutoffs based on 2 standard deviations from the mean rather than optimal sensitivity and specificity...
March 15, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Yoko Endo, Ryuji Ohashi, Shunta Inai, Kazuhiko Yokoshima, Munenaga Nakamizo, Akira Shimizu, Kimihiro Okubo, Zenya Naito
Carcinosarcoma (CS) is a rare tumor, consisting of both carcinomatous and sarcomatous components. In this paper, we present a case of CS arising from a pleomorphic adenoma (PA) of the submandibular gland. A 64-year-old Japanese man presented with a left submandibular mass that had developed for 20 years with complaints of pain for the last 3 months. Magnetic resonance imaging showed a lesion involving the left submandibular gland. The patient underwent total dissection of the left submandibular gland and left cervical lymph nodes...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Yuko Hashimoto, Ko Matsudaira, Susumu S Sawada, Yuko Gando, Ryoko Kawakami, Robert A Sloan, Chihiro Kinugawa, Takashi Okamoto, Koji Tsukamoto, Motohiko Miyachi, Hisashi Naito
BACKGROUND: The relationship between the combination of physical activity (PA) and body mass index (BMI) with low back pain (LBP) is unclear. The present study offers a cross-sectional assessment of how combinations of PA and BMI are related to LBP in Japanese men. METHODS: Participants were 4022 Japanese men (mean age = 47) who underwent regular clinical examinations. PA was measured using a uniaxial accelerometer and divided into tertiles (PAhigh , PAmiddle , PAlow )...
March 9, 2018: BMC Public Health
Rafael Taeho Han, Han-Byul Kim, Young-Beom Kim, Kyungmin Choi, Gi Yeon Park, Pa Reum Lee, JaeHee Lee, Hye Young Kim, Chul-Kyu Park, Youngnam Kang, Seog Bae Oh, Heung Sik Na
Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In the present study, we aimed to identify which receptor could mediate the analgesic effect of intraperitoneal injection of oxytocin and its cellular mechanisms in thermal pain behavior. We found that oxytocin-induced analgesia could be reversed by d(CH2 )5 [Tyr(Me)2 ,Dab5 ] AVP, a vasopressin-1a (V1a) receptor antagonist, but not by desGly-NH2 -d(CH2 )5 [DTyr2 , Thr4 ]OVT, an oxytocin receptor antagonist...
March 2018: Korean Journal of Physiology & Pharmacology
Robin Holtedahl
BAKGRUNN: Knesmerter er blant de vanligste årsaker til konsultasjoner for muskel- og skjelettplager. Siktemålet med denne artikkelen er dels å gi en oversikt over de siste par tiårs forskning på atraumatiske og degenerativt betingede kneplager, dels å vurdere hvorvidt den sedvanlige praksis for utredning og behandling er i samsvar med denne forskningen. KUNNSKAPSGRUNNLAG: Artikkelen er basert på et utvalg av engelskspråklige studier av atraumatiske og degenerative knelidelser funnet ved søk i Medline, manuelle søk i artiklenes litteraturlister og litteraturforslag fra Mendeley...
March 6, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Maik Sliepen, Elsa Mauricio, Matthijs Lipperts, Bernd Grimm, Dieter Rosenbaum
BACKGROUND: Knee osteoarthritis patients may become physically inactive due to pain and functional limitations. Whether physical activity exerts a protective or harmful effect depends on the frequency, intensity, time and type (F.I.T.T.). The F.I.T.T. dimensions should therefore be assessed during daily life, which so far has hardly been feasible. Furthermore, physical activity should be assessed within subgroups of patients, as they might experience different activity limitations. Therefore, this study aimed to objectively describe physical activity, by assessing the F...
February 23, 2018: BMC Musculoskeletal Disorders
Farideh Baghishani, Abbas Mohammadipour, Hossain Hosseinzadeh, Mahmoud Hosseini, Alireza Ebrahimzadeh-Bideskan
Tramadol, a frequently used pain reliever drug, present neurotoxic effects associated to cognitive dysfunction. Moreover, crocin has been reported to have neuroprotective effects. The aim of this study was to assess crocin's capacity to protect learning, and memory abilities on tramadol-treated rats. A total of 35 rats were divided into five groups: Control, Saline, tramadol (50 mg/kg), tramadol + crocin(30 mg/kg), crocin groups and treated orally for 28 consecutive days. Morris water maze (MWM) and passive avoidance (PA) tests were done, followed by dissection of the rat's brains for toluidine blue and TUNEL staining...
February 22, 2018: Metabolic Brain Disease
Louise M Thoma, Dorothy Dunlop, Jing Song, Jungwha Lee, Catrine Tudor-Locke, Elroy J Aguiar, Hiral Master, Meredith B Christiansen, Daniel K White
OBJECTIVE: To compare objectively-measured physical activity (PA) in older adults with symptomatic knee osteoarthritis (SxOA) with similarly aged adults without osteoarthritis (OA) or knee symptoms from the general population. METHODS: We included people age 50-85 years with SxOA from the Osteoarthritis Initiative (OAI, n=491), and people age 50-85 years from the general population from the National Health and Nutrition Examination Survey (NHANES, n=449). A uniaxial accelerometer was worn for >10 hours/day for >4 days in the NHANES in 2003-2004 (Actigraph 7124) and in the OAI in 2008-2010 (Actigraph GT1M)...
February 22, 2018: Arthritis Care & Research
Narasa Madam, Wassim Mosleh, Natdanai Punnanithinont, Andres Carmona-Rubio, Zaid H Said, Umesh C Sharma
Background: Pulmonary hypertension (PH) is an underdiagnosed cause for chest pain in patients without significant coronary artery disease (CAD). Studies showed that enlarged pulmonary arterial (PA) and right ventricular chamber sizes correlate with the severity of PH. Therefore, we studied the association between chest pain, right ventricular dimensions (RVDs), and PA size on coronary coronary tomographic angiography (CCTA). Methods: The CCTA of 87 patients presenting with chest pain without evidence of obstructive CAD was examined...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
P G Genov, V H Timerbaev, A A Grin, O Yu Rebrova
DESIGN: 129 patients scheduled for elective lumbar discectomy in 2010-2013 were enrolled in prospective study. Group K (n=20) underwent general anaesthesia and postoperative analgesia on-demand. Group PMA+SA (n=23) got subarachnoid block and preventive multimodal analgesia (PMA) including ketoprofen, paracetamol and nalbuphine. At PMA group (n=21) general anaesthesia and PMA were used; at PMA+I (n=21) also bupivacaine wound infiltration was administrated; at PlvL4+S (n=20) - depo-corticosteroid was applied locally on affected spinal nerve root; at PMA+IS (n=24) wound infiltration and local corticosteroids were combined...
September 2017: Anesteziologiia i Reanimatologiia
Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Tomasz Grabowski, Agnieszka Klupczynska, Szymon Plewa, Anna Wolc, Magdalena Magiera, Joanna Porażka, Zenon J Kokot, Edmund Grześkowiak
Lapatinib is a tyrosine kinase inhibitor used for the treatment of breast cancer. Paracetamol is an analgesic commonly applied to patients with mild or moderate pain and fever. Cancer patients are polymedicated, which involves high risk of drug interactions during therapy. The aim of the study was to assess the interaction between lapatinib and paracetamol in rats. The rats were divided into three groups of eight animals in each. One group received lapatinib + paracetamol (IL + PA ), another group received lapatinib (IIL ), whereas the last group received paracetamol (IIIPA )...
February 20, 2018: Investigational New Drugs
Saliu Balogun, Tania Winzenberg, Karen Wills, David Scott, Graeme Jones, Michele Callisaya, Dawn Aitken
AIMS: To describe the longitudinal associations between physiological falls risk, and between-person and within-person effects of 25-hydroxyvitamin D (25OHD), physical activity (PA), knee pain and dysfunction in community-dwelling older people. METHODS: Data for 1053 participants (51% women; mean age 63 ± 7.4 years) studied at baseline, 2.5, 5, and 10 years were analysed. Falls risk (Z-score) was measured using the Physiological Profile Assessment. Knee pain and dysfunction were assessed using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC)...
February 5, 2018: Experimental Gerontology
Amir R Kachooei, Nicole A M Heesakkers, Andras Heijink, Bertram The, Denise Eygendaal
BACKGROUND: Few studies have discussed the short-term results of radiocapitellar (RC) prosthetic arthroplasty (PA). In this study, we assessed the short-term to midterm functional and radiographic results of elbows after RC PA. Our secondary aim was to assess the survival of the RC PA. METHODS: We included 19 elbows in 18 patients with a mean follow-up of 35 months (range, 12-88 months). Patients were examined for instability and range of motion and were assessed using Mayo Elbow Performance Index and Oxford Elbow Score at any subsequent visits...
February 1, 2018: Journal of Shoulder and Elbow Surgery
Juan Luis Díaz-Cerrillo, Antonio Rondón-Ramos, Susana Clavero-Cano, Rita Pérez-González, Javier Martinez-Calderon, Alejandro Luque-Suarez
OBJECTIVE: To describe some sociodemographics and clinical characteristics of subjects with Non-specific Chronic Low Back Pain (NCLBP) in Primary Care, as well as to investigate their association with Fear-Avoidance (FA). DESIGN: Cross-sectional. Secondary analysis of an intervention study. LOCATION: Basic Health Areas in Costa del Sol Health District (Málaga, Spain). PARTICIPANTS: An analysis was performed on 147 subjects with NCLBP from a previous intervention study database in Primary Care Physiotherapy (PCP)...
January 30, 2018: Atencion Primaria
C P McDowell, B R Gordon, K L Andrews, C MacDonncha, M P Herring
AIMS: Anxiety is debilitating and associated with numerous mental and physical comorbidities. There is a need to identify and investigate low-risk prevention and treatment strategies. Therefore, the purpose of this study was to investigate cross-sectional and longitudinal associations between different volumes of moderate-to-vigorous physical activity (PA) and anxiety symptoms and status among older adults in Ireland. METHODS: Participants (n = 4175; 56.8% female) aged ⩾50 years completed the International PA Questionnaire (IPAQ) at baseline, and the anxiety subscale of the Hospital Anxiety and Depression Scale at baseline and follow-up (2009-2013)...
January 31, 2018: Epidemiology and Psychiatric Sciences
C M Koolhaas, K Dhana, F J A van Rooij, J D Schoufour, A Hofman, O H Franco
OBJECTIVES: Physical activity (PA) is associated with health-related quality of life (HRQL). The specific PA types that provide beneficial effects in an older population remain unclear. We assessed the association of total PA, walking, cycling, domestic work, sports and gardening with HRQL in middle-aged and elderly adults. DESIGN: Cross-sectional study. SETTING: Rotterdam, the Netherlands. PARTICIPANTS: 5,554 participants, with a mean age of 69 years...
2018: Journal of Nutrition, Health & Aging
Linn Karlsson, Björn Gerdle, Esa-Pekka Takala, Gerhard Andersson, Britt Larsson
Purpose: The purpose of this study was to describe how patients with chronic pain experience physical activity and exercise (PA&E). Method: This qualitative interview study included 16 women and two men suffering from chronic pain and referred to a multimodal pain rehabilitation program. Semi-structured interviews were conducted and qualitative content analysis was used to analyze the interviews. Results: One main theme emerged: "To overcome obstacles and to seize opportunities to be physically active despite chronic pain...
2018: Journal of Pain Research
Lynn R Webster, Eugene R Viscusi, Colville Brown, Jeffrey M Dayno
BACKGROUND: The development and use of abuse-deterrent (AD) opioids is part of a multifaceted strategy to reduce misuse, abuse, and diversion, while maintaining access for patients with severe pain who may benefit from their analgesic efficacy. Morphine AD, extended-release (ER), injection-molded tablets (morphine-ADER-IMT; ARYMO® ER; Egalet US Inc, Wayne, PA) is approved by the FDA as an AD opioid. As part of the characterization of AD opioids, assessments of their human abuse potential (HAP) are required...
January 25, 2018: Current Medical Research and Opinion
Ichiro Takasaki, Ai Watanabe, Masafumi Yokai, Yurie Watanabe, Daichi Hayakawa, Ryota Nagashima, Mamoru Fukuchi, Takuya Okada, Naoki Toyooka, Atsuro Miyata, Hiroaki Gouda, Takashi Kurihara
Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are present in the spinal dorsal horn and dorsal root ganglia, suggesting an important role of PACAP signaling systems in the modulation of spinal nociceptive transmission. Previously, we found that intrathecal (i.t.) injection of PACAP or maxadilan, a selective PACAP type I (PAC1) receptor agonist, induced transient aversive responses followed by a long-lasting mechanical allodynia in mice, suggesting that PACAP-PAC1 receptor systems are involved in chronic pain and that selective PAC1 antagonists may become a new class of analgesics...
January 23, 2018: Journal of Pharmacology and Experimental Therapeutics
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