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Hypercholesterolemia

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https://www.readbyqxmd.com/read/29333817/anthropometric-and-biochemical-assessment-of-nutritional-status-and-dietary-intake-in-school-children-aged-6-14-years-province-of-buenos-aires-argentina
#1
Lorena Lázaro Cuesta, Analía Rearte, Sergio Rodríguez, Melina Niglia, Horacio Scipioni, Diego Rodríguez, Rosalía Salinas, Claudia Sosa, Stella Rasse
INTRODUCTION: Childhood obesity is a global epidemic. School age and adolescence are critical stages for the implementation of eating and lifestyle habits. OBJECTIVE: To assess anthropometric and biochemical assessment of nutritional status and dietary intake in children, their relationship with socioeconomic factors and georeferencing. METHODS: Cross-sectional study in schoolchildren aged 6-14 years from the District of General Pueyrredon, during August-November 2013...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29332588/treatment-strategies-for-hypercholesterolemia
#2
Sarah Clauss, Jacob Hartz
Atherosclerotic disease is a leading cause of morbidity and mortality in adults and is generally thought of as only affecting adults. However, the pathologic changes in vessels leading to atherosclerosis, and an increased risk of cardiovascular disease, have been shown to begin in early adolescence. There is a growing body of literature suggesting that earlier treatment, through lifestyle changes and pharmacotherapy, can help reduce this risk.
January 11, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29332570/proprotein-convertase-subtilisin-kexin-type-9-inhibition-in-cardiovascular-prevention
#3
Ali Ali, Pierluigi Costanzo, Angela Hoye
Elevated levels of Low Density Lipoprotein cholesterol (LDL-C) are directly associated with increased risk for atherosclerotic cardiovascular and cerebrovascular events. Statins have been used to control serum LDL-C and this has translated into reduction in cardiovascular and cerebrovascular events. However, despite high dose statin therapy, LDL-C control may remain inadequate in some patients, particularly those with familial hypercholesterolemia. A new therapeutic approach has emerged in recent years with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors...
January 10, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29332377/comparisons-of-three-different-doses-of-alirocumab-application-in-patients-with-hypercholesterolaemia-a-meta-analysis
#4
Yu-Sheng Zhang, Ye-Hua Hao, Hou-Long Luo, Bao-Cheng Xie, Jian-Ying Fu, Zhi-Kun Zhou
INTRODUCTION: Low high-density lipoprotein cholesterol (HDL-C) and high low-density lipoprotein cholesterol (LDL-C) levels are associated with incidence of cardiovascular disease (CVD). Alirocumab has been considered as an efficacious, safe and promising therapeutic modality for hypercholesterolemia. The purpose of this study is to compare the differences of the three different doses of alirocumab in patients with hypercholesterolaemia. EVIDENCE ACQUISITION: Randomized controlled trials were identified from PubMed, EMBASE, PMC and Cochrane-library databases...
January 11, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29331849/sociodemographic-lifestyle-and-health-determinants-of-suicidal-behaviour-in-malaysia
#5
Yong Kang Cheah, Mohd Azahadi, Siew Nooi Phang, Noor Hazilah Abd Manaf
Suicide has become a serious matter in both developed and developing countries. The objective of the present study is to examine the factors affecting suicidal behaviour among adults in Malaysia. A nationally representative data which consists of 10,141 respondents is used for analysis. A trivariate probit model is utilised to identify the probability of having suicide ideation, suicide plan and suicide attempt. Results of the regression analysis show that to ensure unbiased estimates, a trivariate probit model should be used instead of three separate probit models...
January 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29331793/moderate-dose-simvastatin-therapy-potentiates-the-effect-of-vitamin-d-on-thyroid-autoimmunity-in-levothyroxine-treated-women-with-hashimoto-s-thyroiditis-and-vitamin-d-insufficiency
#6
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Vitamin D preparations reduce titers of thyroid antibodies in women with autoimmune thyroiditis. The same effect was induced by high-dose, but not moderate-dose-, statin therapy. No previous study has investigated the impact of concomitant treatment with a statin and vitamin D on thyroid autoimmunity. METHODS: The study included three matched groups of women with Hashimoto's thyroiditis and low vitamin D status. Groups B (n = 19) and C (n = 20) were treated with vitamin D (2000 IU daily)...
July 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29331538/differential-lipid-metabolism-outcomes-associated-with-adrb2-gene-polymorphisms-in-response-to-two-dietary-interventions-in-overweight-obese-subjects
#7
O Ramos-Lopez, J I Riezu-Boj, F I Milagro, L Goni, M Cuervo, J A Martinez
BACKGROUND AND AIMS: A precise nutrigenetic management of hypercholesterolemia involves the understanding of the interactions between the individual's genotype and dietary intake. The aim of this study was to analyze the response to two dietary energy-restricted interventions on cholesterol changes in carriers of two ADRB2 polymorphisms. METHODS AND RESULTS: A 4-month nutritional intervention was conducted involving two different hypo-energetic diets based on low-fat (LF) and moderately high-protein (MHP) dietary patterns...
December 5, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29331507/adropin-an-endocrine-link-between-the-biological-clock-and-cholesterol-homeostasis
#8
Sarbani Ghoshal, Joseph R Stevens, Cyrielle Billon, Clemence Girardet, Sadichha Sitaula, Arthur S Leon, D C Rao, James S Skinner, Tuomo Rankinen, Claude Bouchard, Marinelle V Nuñez, Kimber L Stanhope, Deborah A Howatt, Alan Daugherty, Jinsong Zhang, Matthew Schuelke, Edward P Weiss, Alisha R Coffey, Brian J Bennett, Praveen Sethupathy, Thomas P Burris, Peter J Havel, Andrew A Butler
OBJECTIVE: Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic control and vascular function. METHODS: Associations between plasma adropin concentrations, demographics (sex, age, BMI) and circulating biomarkers of lipid and glucose metabolism were assessed in plasma obtained after an overnight fast in humans. The regulation of adropin expression was then assessed in silico, in cultured human cells, and in animal models...
December 30, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29330433/effect-of-atorvastatin-on-the-gut-microbiota-of-high-fat-diet-induced-hypercholesterolemic-rats
#9
Tariq Jamal Khan, Youssri M Ahmed, Mazin A Zamzami, Saleh A Mohamed, Imran Khan, Othman A S Baothman, Mohamed G Mehanna, Muhammad Yasir
The aim of the present study was to investigate alterations in gut microbiota associated with hypercholesterolemia and treatment with atorvastatin, a commonly prescribed cholesterol-lowering drug. In this study, seven experimental groups of rats were developed based on diets [high-fat diet (HFD) and normal chow diet (NCD)] and various doses of atorvastatin in HFD and NCD groups. 16S rRNA amplicon sequencing was used to analyze the gut microbiota. Atorvastatin significantly reduced the cholesterol level in treated rats...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29326775/a-systematic-review-on-the-prevalence-of-acute-myocardial-infarction-in-iran
#10
REVIEW
Jaber Mohseni, Toba Kazemi, Mahmood Hosseinzadeh Maleki, Hossein Beydokhti
In Iran, cardiovascular diseases are the most common causes of death. We aimed to perform a systematic review on the prevalence of acute myocardial infarction (AMI) in Iran based on Persian and English papers had been published from 1985 to 2015. Among 267 initially found articles, 142 were excluded; finally, a total number of 40 articles were found relevant which were reduced to 18. Smoking, hypertension, diabetes mellitus, and hypercholesterolemia were the most common risk factors for AMI. Premature MI prevalence was high in men, and smoking was the most common risk factor among young people...
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29326146/prior-authorization-requirements-for-proprotein-convertase-subtilisin-kexin-type-9-inhibitors-across-us-private-and-public-payers
#11
Jalpa A Doshi, Justin T Puckett, Michael S Parmacek, Daniel J Rader
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9is) are an innovative treatment option for patients with familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease who require further lowering of low-density lipoprotein cholesterol. However, the high costs of these agents have spurred payers to implement utilization management policies to ensure appropriate use. We examined prior authorization (PA) requirements for PCSK9is across private and public US payers...
January 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29323716/oxidative-burden-in-familial-hypercholesterolemia
#12
REVIEW
Hamid Mollazadeh, Federico Carbone, Fabrizio Montecucco, Matteo Pirro, Amirhossein Sahebkar
Familial hypercholesterolemia (FH) is a genetic disorder characterized by high serum levels of low-density lipoprotein cholesterol (LDL-c). FH is characterized by accelerated development of atherosclerosis and represents the most frequent hereditary cause of premature coronary heart disease. Mutations of the LDL receptor gene are the genetic signature of FH, resulting in abnormal levels of circulating LDLs. Moreover, FH promotes the generation of reactive oxygen species (ROS) which is another key mechanism involved in atherosclerosis development and progression...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29321397/associations-between-socioeconomic-status-and-the-prevalence-and-treatment-of-hypercholesterolemia-in-a-general-japanese-population-nippon-data2010
#13
Naoko Fujiyoshi, Hisatomi Arima, Atsushi Satoh, Toshiyuki Ojima, Nobuo Nishi, Nagako Okuda, Aya Kadota, Takayoshi Ohkubo, Atsushi Hozawa, Naoki Nakaya, Akira Fujiyoshi, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
AIM: To investigate associations between socioeconomic status (SES) and the prevalence and treatment status of hypercholesterolemia in a general Japanese population. METHODS: In 2010, we established a cohort study of 2417 adults (age 20-91 yr) from 300 randomly selected areas across Japan who participated in the National Health and Nutrition Survey of Japan. We cross-sectionally examined an association between SES and (1) prevalence of hypercholesterolemia in 2417 participants (999 men and 1418 women) and (2) not receiving medication for hypercholesterolemia in 654 participants (215 men and 439 women)...
January 11, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29321389/aortic-root-calcification-score-as-an-independent-factor-for-predicting-major-adverse-cardiac-events-in-familial-hypercholesterolemia
#14
Hirofumi Okada, Hayato Tada, Kenshi Hayashi, Hiroki Kawashima, Tadanori Takata, Kenji Sakata, Atsushi Nohara, Hiroshi Mabuchi, Masakazu Yamagishi, Masa-Aki Kawashiri
AIM: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hypercholesterolemia (FH). METHODS: One hundred thirteen consecutive Japanese patients with heterozygous FH (male=54, mean age=52.1±15.6 years, mean LDL-C=299.0±94.6 mg/dL), without known coronary artery disease, who underwent 64-detector row CCTA were retrospectively evaluated...
January 10, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29321358/genetic-variants-influencing-lipid-levels-and-risk-of-dyslipidemia-in-chinese-population
#15
Huaichao Luo, Xueping Zhang, Ping Shuai, Yuanying Miao, Zimeng Ye, Ying Lin
Recently, several human genetic and genomewide association studies (GWAS) have discovered many genetic loci that are associated with the concentration of the blood lipids. To confirm the reported loci in Chinese population, we conducted a crosssection study to analyse the association of 25 reported SNPs, genotyped by the ABI SNaPshot method, with the blood levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) in 1900 individuals by multivariate analysis...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29321129/novel-reversible-model-of-atherosclerosis-and-regression-using-oligonucleotide-regulation-of-the-ldl-receptor
#16
Debapriya Basu, Yunying Hu, Lesley-Ann Huggins, Adam E Mullick, Mark J Graham, Tomasz A Wietecha, Shelley L Barnhart, Allison Mogul, Katharina Pfeiffer, Andreas Zirlik, Edward A Fisher, Karin E Bornfeldt, Florian Willecke, Ira J Goldberg
Rationale: Animal models have been used to explore factors that regulate atherosclerosis. More recently, they have been used to study the factors that promote loss of macrophages and reduction in lesion size after lowering of plasma cholesterol levels. However, current animal models of atherosclerosis regression require challenging surgeries, time-consuming breeding strategies, and/or methods that block liver lipoprotein secretion. Objective: We sought to develop a more direct and time-effective method to create and then reverse hypercholesterolemia as well as atherosclerosis via transient knockdown of the hepatic LDL receptor (LDLR) followed by its rapid restoration...
January 10, 2018: Circulation Research
https://www.readbyqxmd.com/read/29320745/the-foxo1-inducible-transcriptional-repressor-zfp125-causes-hepatic-steatosis-and-hypercholesterolemia
#17
Gustavo W Fernandes, Barbara M L C Bocco, Tatiana L Fonseca, Elizabeth A McAninch, Sungro Jo, Lattoya J Lartey, InSug O-Sullivan, Terry G Unterman, Nailliw Z Preite, Robin M Voigt, Christopher B Forsyth, Ali Keshavarzian, Richárd Sinkó, Allison B Goldfine, Mary E Patti, Miriam O Ribeiro, Balázs Gereben, Antonio C Bianco
Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an ∼60% reduction in liver zinc-finger protein-125 (Zfp125) expression. Zfp125 is a Foxo1-inducible transcriptional repressor that causes lipid accumulation in the AML12 mouse hepatic cell line and liver steatosis in mice by reducing liver secretion of triglycerides and hepatocyte efflux of cholesterol. Zfp125 acts by repressing 18 genes involved in lipoprotein structure, lipid binding, and transport...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29319751/effects-of-maternal-high-fat-intake-during-pregnancy-and-lactation-on-total-cholesterol-and-adipose-tissue-in-neonatal-rats
#18
M S Lima, G S Perez, G L Morais, L S Santos, G S Cordeiro, R D Couto, T C B J Deiró, C G Leandro, J M Barreto-Medeiros
AIM: Obesity during pregnancy is one of the most established risk factors for negative long-term programming. The aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during pregnancy and lactation on the weight gain, visceral adipose tissue and cholesterolemia in neonatal rats. METHODS: Wistar rats were divided into two groups according to the mother's diet during pregnancy and lactation: Control group (CG, n = 12) were the offspring of rats fed a standard diet (4% lipid) and the Test group (TG, n = 12) were pups rats fed on a high fat diet (23% lipid)...
January 8, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29313544/dietary-supplementation-of-defatted-kenaf-hibiscus-cannabinus-l-seed-meal-and-its-phenolics-saponins-rich-extract-effectively-attenuates-diet-induced-hypercholesterolemia-in-rats
#19
Kim Wei Chan, Maznah Ismail, Norhaizan Mohd Esa, Mustapha Umar Imam, Der Jiun Ooi, Nicholas M H Khong
Kenaf is one of the important commercial fiber crops worldwide and defatted kenaf seed meal (DKSM) is a secondary by-product from the kenaf industry. Thus, efforts to turn this low-cost agricultural waste into value-added functional food ingredients will definitely bring advantageous impacts to the community health, environment and economy. The present study was aimed to investigate the cardioprotective properties of DKSM and its phenolics-saponins rich extract (PSRE) in diet-induced hypercholesterolemic rat model...
January 9, 2018: Food & Function
https://www.readbyqxmd.com/read/29312596/ra-and-%C3%AF-3-pufa-co-treatment-activates-autophagy-in-cancer-cells
#20
Shenglong Zhu, Guangxiao Lin, Ci Song, Yikuan Wu, Ninghan Feng, Wei Chen, Zhao He, Yong Q Chen
Retinoic acid (RA), is a promising therapeutic agent for the treatment of breast cancer. However, metabolic disorders and drug resistance reduce the efficacy of RA. In this study, we found that RA and ω-3 polyunsaturated fatty acids (ω-3 PUFAs) synergistically induced cell death in vitro and in vivo and autophagy activation. Moreover, RA-induced hypercholesterolemia was completely corrected by ω-3 PUFA supplementation. In addition, we demonstrated that the effects of this combination on the autophagic flux were independent of the two major canonic regulatory complexes controlling autophagic vesicle formation...
December 12, 2017: Oncotarget
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