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https://www.readbyqxmd.com/read/28212263/shoulder-synovial-fluid-lipoprotein-levels-and-their-relationship-to-the-rotator-cuff
#1
Daniel E Davis, Alexa Narzikul, Daniel Sholder, Mark Lazarus, Surena Namdari, Joseph Abboud
INTRODUCTION: Rotator cuff pathology has been proposed to occur through intrinsic and extrinsic mechanisms. Hyperlipidemia has been proposed as a mechanism of intrinsic rotator cuff pathology. This prospective observational study evaluates serum and synovial lipid profiles in patients with and without rotator cuff tears to further define the relationship of cholesterol and rotator cuff pathology. METHODS: Patients were prospectively enrolled with intact rotator cuff (37 patients) and rotator cuff tear requiring a repair (40 patients) groups...
March 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28209797/roles-of-vascular-oxidative-stress-and-nitric-oxide-in-the-pathogenesis-of-atherosclerosis
#2
REVIEW
Ulrich Förstermann, Ning Xia, Huige Li
Major reactive oxygen species (ROS)-producing systems in vascular wall include NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase, the mitochondrial electron transport chain, and uncoupled endothelial nitric oxide (NO) synthase. ROS at moderate concentrations have important signaling roles under physiological conditions. Excessive or sustained ROS production, however, when exceeding the available antioxidant defense systems, leads to oxidative stress. Animal studies have provided compelling evidence demonstrating the roles of vascular oxidative stress and NO in atherosclerosis...
February 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28209601/the-influence-of-rosuvastatin-upon-the-gastrointestinal-microbiota-and-host-gene-expression-profiles
#3
James A Nolan, Peter Henry Skuse, Kalaimathi Govindarajan, Elaine Patterson, Nina Konstantinidou, Patrick G Casey, John MacSharry, Fergus Shanahan, Catherine Stanton, Colin Hill, P D Cotter, Susan A Joyce, Cormac Gm Gahan
Statins are the most widely prescribed medications worldwide for the treatment of hypercholesterolemia. They inhibit the activity of 3-hydroxy-3-methylglutaryl co enzyme A reductase (HMG-R) an enzyme involved in cholesterol synthesis in higher organisms and in isoprenoid biosynthesis in some bacteria. We hypothesized that statins may influence the microbial community in the gut through either direct inhibition or indirect mechanisms involving alterations to host responses. We therefore examined the impact of rosuvastatin (RSV) on the community structure of the murine gastrointestinal microbiota...
February 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28209162/fatty-acid-and-cholesterol-profiles-hypocholesterolemic-atherogenic-and-thrombogenic-indices-of-broiler-meat-in-the-retail-market
#4
Youssef A Attia, Mohammed A Al-Harthi, Mohamed A Korish, Mohamed M Shiboob
BACKGROUND: Broiler meat is an essential source of food due to its favourable effects on human health derived from its protein, fats, minerals, vitamins and its bioactive components. METHODS: A total of 90 carcasses were collected from the retail market in Jeddah city, Saudi Arabia during April, May and June 2014 to determine the effects of meat type (frozen vs. fresh) and sources within fresh types (A, B, C) vs. frozen types (D, E and F) on their fatty acid profiles, cholesterol, their hypocholesterolemic, atherogenic and thrombogenic indices, and on their antioxidants' status...
February 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28205331/new-insights-to-the-mechanisms-underlying-atherosclerosis-in-rheumatoid-arthritis
#5
REVIEW
Mahdi Mahmoudi, Saeed Aslani, Reza Fadaei, Ahmad Reza Jamshidi
Rheumatoid arthritis (RA) is an inflammatory circumstance, which has been associated with increased risk of cardiovascular disease (CVD). Although RA management has been promoted, mortality rate due to CVD remains remarkable. Approximately, 50% of premature death cases in RA are attributable to CVD. RA patients develop atherosclerosis in a greater amount than the general population. Moreover, atherosclerotic lesions develop rapidly in RA patients and might be more susceptible to rupture. The inflammatory condition of RA, such as cytokines, abnormally activated immune cells, play a role in the initiation, perpetuation and exacerbation of atherosclerosis...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28205311/management-of-cardiovascular-risk-factors-in-patients-with-anca-associated-vasculitis
#6
Carsten Paul Bramlage, Juliane Kröplin, Manuel Wallbach, Joan Minguet, Katherine Helen Smith, Stephan Lüders, Joachim Schrader, Susan Patschan, Oliver Gross, Cornelia Deutsch, Peter Bramlage, Gerhard Anton Müller, Michael Koziolek
OBJECTIVES: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is accompanied by increased cardiovascular (CV) risk. Treatment of AAV patients includes the management of conventional CV risk factors, primarily hypertension and hypercholesterolemia, while lipoprotein(a) (LP(a)) is an emerging potential target. METHODS: We performed a multicenter, retrospective study in Germany. Patients were considered if they were between 18 and 90 years old and presented with AAV...
February 16, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28205167/the-use-of-l-sidol-transgenic-mice-as-a-murine-model-to-study-hypercholesterolemia-and-atherosclerosis
#7
Eser J Zerenturk, Anna C Calkin
There are many advantages to the use of mice as a model to study the regulation of cholesterol metabolism. Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR -/-) mice and apolipoprotein E deficient (ApoE) -/- mice. Herein, we describe the recently generated mouse model, L-sIDOL Tg mice, which express a dominant active form of Inducible Degrader Of the Low-density lipoprotein receptor (IDOL) in a liver-specific manner. This murine model offers significant advantages over previously established models for the study of hypercholesterolemia and atherosclerosis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28204827/hepatic-hnf1-transcription-factors-control-the-induction-of-pcsk9-mediated-by-rosuvastatin-in-normolipidemic-hamsters
#8
Bin Dong, Amar Bahadur Singh, Vikram Ravindra Shende, Jingwen Liu
Proprotein convertase subtilisin/kexin type 9 (PCSK9) impedes low‑density lipoprotein (LDL) receptor (LDLR)-mediated LDL-cholesterol uptake and has hence emerged as a critical regulator of serum cholesterol levels and a new therapeutic target for the treatment of hypercholesterolemia. Statins have been shown to elevate circulating PCSK9 levels by stimulating PCSK9 gene transcription, which reduces the clinical efficacy of statin in LDL‑cholesterol reduction. The transcription of PCSK9 is partially controlled by the hepatocyte nuclear factor 1 (HNF1) binding site embedded in the proximal region of its promoter...
February 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28203441/lipoprotein-a-and-inhibitors-of-proprotein-convertase-subtilisin-kexin-type-9
#9
COMMENT
Kazuhiko Kotani, Maciej Banach
Lipoprotein(a) [Lp(a)] has been identified as a risk factor for cardiovascular disease. Lp(a) levels are also high under certain clinical conditions, including familial hypercholesterolemia and high blood low-density lipoprotein (LDL) cholesterol levels. Few effective generic therapies for modulating Lp(a) have been developed. However, new therapies involving inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) using monoclonal antibodies have markedly reduced the blood LDL levels-and the Lp(a) levels as well...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28202216/lifestyle-and-health-determinants-of-cardiovascular-disease-among-greek-older-adults-living-in-eastern-aegean-islands-an-adventure-within-the-medis-study
#10
Alexandra Foscolou, Evangelos Polychronopoulos, Efstratia Paka, Stefanos Tyrovolas, Vassiliki Bountziouka, Akis Zeimbekis, Dimitra Tyrovola, Dilek Ural, Demosthenes Panagiotakos
OBJECTIVE: The aim of the present study was to evaluate lifestyle and health determinants of cardiovascular disease (CVD) risk among Greek elderly residents living in Eastern Aegean islands, in both Greece and Turkey. METHODS: Under the context of the MEDIS study, 724 older adults (aged 65 to 100 years) from 8 Eastern Aegean Sea Greek islands (n=100 living in Samothrace, 142 in Lesvos, 150 in Limnos, 76 in Ikaria, 52 in Kassos, 149 in Rhodes and Karpathos) and from Turkey (n=55older adults of Greek origin living on Gökçeada Island) were voluntarily recruited...
November 16, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28199789/plasma-cholesterol-lowering-activity-of-tartary-buckwheat-protein
#11
Chengnan Zhang, Rui Zhang, Yuk Man Li, Ning Liang, Yimin Zhao, Hanyue Zhu, Zouyan He, Jianhui Liu, Wangjun Hao, Rui Jiao, Ka Ying Ma, Zhen-Yu Chen
Previous research has shown Tartary buckwheat flour is capable of reducing plasma cholesterol. The present study was to examine the effect of rutin and Tartary buckwheat protein on plasma total cholesterol (TC) in hypercholesterolemia hamsters. In the first animal experiment, 40 male hamsters were divided into four groups fed either the control diet or one of the three experimental diets containing 8.2 mmol rutin, 8.2 mmol quercetin, and 2.5 g kg-1 cholestyramine, respectively. Result showed that only cholestyramine but not rutin and its aglycone quercetin decreased plasma TC, suggesting rutin was not the active ingredient responsible for plasma TC-lowering activity of Tartary buckwheat flour...
February 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28199412/modulation-of-cholesterol-transport-by-maternal-hypercholesterolemia-in-human-full-term-placenta
#12
Ran Zhang, Shan Dong, Wei-Wei Ma, Xue-Ping Cai, Zhi-Yin Le, Rong Xiao, Qi Zhou, Huan-Ling Yu
The significance of maternal cholesterol transporting to the fetus under normal as well as pathological circumstances is less understood. The objective of this study was to observe the effects of maternal hypercholesterolemia on placental cholesterol transportation. Human full-time placenta, maternal and venous cord blood were sampled at delivery from the pregnant women with serum total cholesterol (TC) concentrations at third trimester higher than 7.25 mM (n = 19) and the pregnant women with normal TC concentrations (n = 19)...
2017: PloS One
https://www.readbyqxmd.com/read/28192012/impact-of-gender-on-satisfaction-and-confidence-in-cholesterol-control-among-veterans-at-risk-for-cardiovascular-disease
#13
Karen M Goldstein, Karen M Stechuchak, Leah L Zullig, Eugene Z Oddone, Maren K Olsen, Felicia A McCant, Lori A Bastian, Bryan C Batch, Hayden B Bosworth
BACKGROUND: Compared with men, women have poorer lipid control. Although potential causes of this disparity have been explored, it is unknown whether patient-centered factors such as satisfaction and confidence contribute. We evaluated (1) whether satisfaction with lipid control and confidence in ability to improve it vary by gender and (2) whether sociodemographic characteristics modify the association. MATERIALS AND METHODS: We evaluated baseline survey responses from the Cardiovascular Intervention Improvement Telemedicine Study, including self-rated satisfaction with cholesterol levels and confidence in controlling cholesterol...
February 13, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28190747/effect-of-statins-as-a-secondary-chemopreventive-agent-among-individuals-with-non-muscle-invasive-bladder-cancer-a-population-based-analysis
#14
Patrick O Richard, Ardalan E Ahmad, Shaheena Bashir, Robert J Hamilton, Robert K Nam, Ricardo Leao, Claudio Jeldres, Girish S Kulkarni
BACKGROUND: Non-muscle-invasive bladder cancer (NMIBC) is especially prevalent among the elderly. Many patients with NMIBC also have significant concomitant comorbidities, including cardiovascular diseases and hypercholesterolemia. Statins are the most commonly used cholesterol-depleting agents, and they may possess anticancer properties. The objective of this population-based study was to evaluate the effect of statins on the survival of individuals diagnosed with NMIBC. METHODS: This is a retrospective population-based cohort study that used administrative databases to identify individuals 66 years of age and older who were diagnosed with NMIBC between 1992 and 2012...
February 9, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28189002/abdominal-aortic-aneurysm-an-independent-disease-to-atherosclerosis
#15
REVIEW
Bradley J Toghill, Athanasios Saratzis, Matthew J Bown
Atherosclerosis and abdominal aortic aneurysms (AAAs) are multifactorial and polygenic diseases with known environmental and genetic risk factors that contribute toward disease development. Atherosclerosis represents an important independent risk factor for AAA, as people with AAA often have atherosclerosis. Studies have shown that comorbidity is usually between ~25% and 55%, but it is still not fully known whether this association is causal or a result of common shared risk profiles. Most recent epidemiological, clinical, and biological evidence suggests that the two pathologies are more distinct than traditionally thought...
January 29, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28186442/clinical-determinants-and-treatment-gaps-in-familial-hypercholesterolemia-data-from-a-multi-ethnic-regional-health-service
#16
Barak Zafrir, Ayman Jubran, Gil Lavie, David A Halon, Moshe Y Flugelman, Chen Shapira
Background Familial hypercholesterolemia is characterized by markedly increased low-density lipoprotein cholesterol and risk for premature atherosclerotic cardiovascular disease. Models of care vary and reflect differing health policies and resources. The availability of electronic databases may enable better identification and assessment of familial hypercholesterolemia in the community. Methods A regional healthcare database was utilized to identify patients with a high probability of familial hypercholesterolemia, clinically defined by age-dependent-peak low-density lipoprotein cholesterol cutoffs and exclusion of secondary causes of severe hypercholesterolemia...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28185594/sleep-apnoea-in-australian-men-disease-burden-co-morbidities-and-correlates-from-the-australian-longitudinal-study-on-male-health
#17
Chamara Visanka Senaratna, Dallas R English, Dianne Currier, Jennifer L Perret, Adrian Lowe, Caroline Lodge, Melissa Russell, Sashane Sahabandu, Melanie C Matheson, Garun S Hamilton, Shyamali C Dharmage
BACKGROUND: Obstructive sleep apnoea is a common disorder with under-rated clinical impact, which is increasingly being recognised as having a major bearing on global disease burden. Men are especially vulnerable and become a priority group for preventative interventions. However, there is limited information on prevalence of the condition in Australia, its co-morbidities, and potential risk factors. METHODS: We used data from 13,423 adult men included in the baseline wave of Ten to Men, an Australian national study of the health of males, assembled using stratified cluster sampling with oversampling from rural and regional areas...
October 31, 2016: BMC Public Health
https://www.readbyqxmd.com/read/28185417/left-main-coronary-angioplasty-of-a-9-year-old-child-with-bioresorable-vascular-scaffold
#18
Hasmukh Ravat, Swati Garekar, Vishal Changela
Familial hypercholesterolemia is an autosomal dominant disorder due to mutations in the low-density lipoprotein receptor gene, characterized by skin and tendon xanthomas, xanthelasmas, and increased risk of premature coronary artery disease. Here, we report a case of 9-year-old girl who presented with angina and dyspnoea on exertion with xanthomas and an elevated serum cholesterol and triglyceride. She had severe stenosis of the left main coronary artery (LMCA) requiring angioplasty and placement of Bioresorbable vascular scaffold (BVS)...
February 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28183844/association-between-posterior-left-atrial-adipose-tissue-mass-and-atrial-fibrillation
#19
Alexander R van Rosendael, Aukelien C Dimitriu-Leen, Philippe J van Rosendael, Melissa Leung, Jeff M Smit, Antti Saraste, Juhani Knuuti, Rob J van der Geest, Britt W H van der Arend, Erik W van Zwet, Arthur J Scholte, Victoria Delgado, Jeroen J Bax
BACKGROUND: Epicardial adipose tissue located close to the atrial wall can change the electric conduction of the left atrium, potentially leading to atrial fibrillation (AF). The aim of this study was to assess whether an increased atrial adipose tissue mass posterior to the left atrium is related to AF independent of demographical and cardiovascular risk factors. METHODS AND RESULTS: Two hundred patients with AF and 200 patients without AF who underwent computed tomographic angiography were included...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28179607/half-a-century-tales-of-familial-hypercholesterolemia-fh-in-japan
#20
Hiroshi Mabuchi
Familial hypercholesterolemia (FH) is a disease characterized by a triad: elevated low-density lipoprotein (LDL) cholesterol, tendon xanthomas, and premature coronary heart disease. Thus, it can be considered as a model disease for hypercholesterolemia and atherosclerotic cardiovascular disease (ASCVD). For the diagnosis of hetero-FH, the detection of Achilles tendon xanthomas by palpation or on X-ray is an indispensable diagnostic skill in clinical lipidology. To prevent the under-diagnosis and under-treatment of FH, the diagnostic criteria should be more convenient and user-friendly...
February 8, 2017: Journal of Atherosclerosis and Thrombosis
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