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https://www.readbyqxmd.com/read/28638568/dizziness-in-a-community-hospital-central-neurological-causes-clinical-predictors-and-diagnostic-yield-and-cost-of-neuroimaging-studies
#1
Hussam Ammar, Rukma Govindu, Ragai Fouda, Wael Zohdy, Emilio Supsupin
Objectives: Neuroimaging is contributing to the rising costs of dizziness evaluation. This study examined the rate of central neurological causes of dizziness, relevant clinical predictors, and the costs and diagnostic yields of neuroimaging in dizziness assessment. Methods: We retrospectively reviewed the records of 521 adult patients who visited the hospital during a 12-month period with dizziness as the chief complaint. Clinical findings were analyzed using Fisher's exact test to determine how they correlated with central neurological causes of dizziness identified by neuroimaging...
March 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28638412/molecular-identification-of-aminoglycoside-modifying-enzymes-and-plasmid-mediated-quinolone-resistance-genes-among-klebsiella-pneumoniae-clinical-isolates-recovered-from-egyptian-patients
#2
Mohamed F El-Badawy, Wael M Tawakol, Shaymaa W El-Far, Ibrahim A Maghrabi, Saleh A Al-Ghamdi, Moselhy S Mansy, Mohammed S Ashour, Mohamed M Shohayeb
Inappropriate use of antibiotics in clinical settings is thought to have led to the global emergence and spread of multidrug-resistant pathogens. The goal of this study was to investigate the prevalence of genes encoding aminoglycoside resistance and plasmid-mediated quinolone resistance among clinical isolates of Klebsiella pneumoniae. All K. pneumoniae isolates were phenotypically identified using API 20E and then confirmed genotypically through amplification of the specific K. pneumoniae phoE gene. All isolates were genotyped by the enterobacterial repetitive intergenic consensus polymerase chain reaction technique (ERIC-PCR)...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28634307/prefrontal-neurons-encode-a-solution-to-the-credit-assignment-problem
#3
Wael F Asaad, Peter M Lauro, János A Perge, Emad N Eskandar
To adapt successfully to our environments, we must use the outcomes of our choices to guide future behavior. Critically, we must be able to correctly assign credit for any particular outcome to the causal features which preceded it. In some cases, the causal features may be immediately evident, whereas in others they may be separated in time or intermingled with irrelevant environmental stimuli, creating a potentially nontrivial credit assignment problem. We examined the neuronal representation of information relevant for credit assignment in the dorsolateral prefrontal cortex (dPFC) of two male rhesus macaques performing a task that elicited key aspects of this problem...
June 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28629768/does-the-duration-of-symptoms-of-anal-fissure-impact-its-response-to-conservative-treatment-a-prospective-cohort-study
#4
Sameh Hany Emile, Hesham Elgendy, Hossam Elfeki, Alaa Magdy, Ahmed Aly Abdelmawla, Mahmoud Abdelnaby, Wael Khafagy
BACKGROUND: Conservative treatment is the first line of treatment for anal fissure. The current study aimed to evaluate the impact of symptom duration on the response of anal fissure to conservative treatment. PATIENTS AND METHODS: This prospective study was conducted on sixty patients with acute or chronic anal fissure who were treated conservatively with bulking agents, Sitz baths, and topical glyceryl trinitrate (GTN) 0.2%. Pain and constipation were assessed prior to treatment and at 6 weeks after therapy using visual analogue scale (VAS) and Wexner constipation score...
June 16, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28624660/comparative-study-on-radiolabeling-and-biodistribution-of-core-shell-silver-polymeric-nanoparticles-based-theranostics-for-tumor-targeting
#5
Nourihan S Farrag, Hanan A El-Sabagh, Abdulaziz M Al-Mahallawi, Abeer M Amin, Ahmed AbdEl-Bary, Wael Mamdouh
A simple and rapid method for radiolabeling of three types of Ag NPs has been performed using (125)I isotope, with high labeling yields, >90% without disturbing the optical properties. All the factors affecting labeling yield were studied. In order to monitor the in-vivo tissue uptake of radiolabeled Ag NPs using γ-rays, Ag-based radioiodo-NPs with a maximum labeling yield were intravenously injected in normal and solid tumor bearing mice. The preliminary biodistribution study revealed that this new radioiodo-NPs have a high affinity to be localized in the tumor site for a long period of time...
June 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28624559/hereditary-factors-are-unlikely-behind-unusual-pattern-of-early-onset-colorectal-cancer-in-egyptians-a-study-of-family-history-and-pathology-features-in-egyptians-with-large-bowel-cancer-cross-sectional-study
#6
Ahmed A Abou-Zeid, Wael A Jumuah, Essam F Ebied, Karim Sabry Abd El Samee Atia, Yasser El Ghamrini, Dina A Somaie
BACKGROUND: Colorectal cancer in Egypt has a higher incidence in young patients compared to western countries, where the disease is more prevalent in the old age group. This difference has been attributed to higher incidence of hereditary cancers in young Egyptian patients. The aim of this study is to compare the family history criteria and pathology features of tumors in young (≤40 years) and old (>40 years) Egyptian patients with adenocarcinoma of the colon and rectum. MATERIALS AND METHODS: This is the analysis of our prospectively collected data on the pathology features of tumors in 313 consecutive patients (133 young, 180 old) with colorectal cancer presenting to the Department of Surgery within an eight-year period...
June 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28624162/stuck-between-a-rock-and-a-hard-place-ild-nsclc%C3%A2-%C3%A2-lim
#7
EDITORIAL
Waël C Hanna
No abstract text is available yet for this article.
May 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28623102/the-enemy-of-good-is-better
#8
EDITORIAL
Waël C Hanna
No abstract text is available yet for this article.
May 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28621291/role-of-endoscopic-ultrasound-and-endoscopic-ultrasound-guided-fine-needle-aspiration-in-endoscopic-biopsy-negative-gastrointestinal-lesions
#9
Hussein Hassan Okasha, Mohamed Naguib, Mohamed El Nady, Reem Ezzat, Emad Al-Gemeie, Waleed Al-Nabawy, Wael Aref, Ahmed Abdel-Moaty, Karim Essam, Ahmed Hamdy
BACKGROUND AND OBJECTIVES: Many cases of gastrointestinal (GI) tumors as lymphoma, adenocarcinoma, and most of submucosal tumors (SMT) such as gastrointestinal stromal tumor (GIST) and leiomyoma are difficult to diagnose as they frequently yield negative endoscopic biopsies. We evaluated the accuracy of endoscopic ultrasound (EUS) and EUS-guided fine-needle aspiration (EUS-FNA) in the diagnosis of endoscopic biopsy negative GI tumors. PATIENTS AND METHODS: One hundred and nine patients with biopsy negative GI tumors were included in this prospective study...
May 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28621084/coregulation-of-the-cyclic-lipopeptides-orfamide-and-sessilin-in-the-biocontrol-strain-pseudomonas-sp-cmr12a
#10
Feyisara E Olorunleke, Nam P Kieu, Evelien De Waele, Marc Timmerman, Marc Ongena, Monica Höfte
Cyclic lipopeptides (CLPs) are synthesized by nonribosomal peptide synthetases (NRPS), which are often flanked by LuxR-type transcriptional regulators. Pseudomonas sp. CMR12a, an effective biocontrol strain, produces two different classes of CLPs namely sessilins and orfamides. The orfamide biosynthesis gene cluster is flanked up- and downstream by LuxR-type regulatory genes designated ofaR1 and ofaR2, respectively, whereas the sessilin biosynthesis gene cluster has one LuxR-type regulatory gene which is situated upstream of the cluster and is designated sesR...
June 15, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28615524/interleukin-15-stimulates-natural-killer-cell-mediated-killing-of-both-human-pancreatic-cancer-and-stellate-cells
#11
Jonas R M Van Audenaerde, Jorrit De Waele, Elly Marcq, Jinthe Van Loenhout, Eva Lion, Johan M J Van den Bergh, Ralf Jesenofsky, Atsushi Masamune, Geert Roeyen, Patrick Pauwels, Filip Lardon, Marc Peeters, Evelien L J Smits
Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancer-related death in Western countries with a 5-year survival rate below 5%. One of the hallmarks of this cancer is the strong desmoplastic reaction within the tumor microenvironment (TME), orchestrated by activated pancreatic stellate cells (PSC). This results in a functional and mechanical shield which causes resistance to conventional therapies. Aiming to overcome this resistance by tackling the stromal shield, we assessed for the first time the capacity of IL-15 stimulated natural killer (NK) cells to kill PSC and pancreatic cancer cells (PCC)...
May 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28613111/synthesis-and-anticancer-activity-of-new-indolyl-pyrazolyl-1-3-4-oxadiazole-thioglycosides-and-acyclic-nucleoside-analogs
#12
Wael A El-Sayed, Walaa I El-Sofany, Hoda A R Hussein, Nahed M Fathi
New [(Indolyl)pyrazolyl]-1,3,4-oxadiazole compounds and their derived thioglycosides as well as the corresponding sugar hydrazones were synthesized. The acyclo C-nucleoside analogs of the oxadiazoline base system were also prepared by reaction of acid hydrazides with aldehydo sugars followed by one pot process encompassing acetylation and cyclization of the synthesized hydrazones. The anticancer activity of the newly synthesized compounds was studied against colorectal carcinoma (HCT116), breast adenocarcinoma (MCF7) and prostate cancer (PC3) human tumor cell lines and a number of compounds showed moderate to high activities...
June 14, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28612147/fluoroscopic-targeting-of-wallstents-and-amplatzer-vascular-plugs-in-sharp-recanalization-of-chronic-venous-occlusions
#13
Minhaj S Khaja, Jeffrey Forris Beecham Chick, Ari D Schuman, Kyle J Cooper, Bill S Majdalany, Wael E Saad, David M Williams
INTRODUCTION/PURPOSE: Sharp recanalization of chronic venous occlusions is usually performed with targeting of wire-capture devices like loop snares or balloons. We describe sharp recanalization of chronic venous occlusions using self-expanding stents and vascular plugs. MATERIAL AND METHODS: We retrospectively reviewed all sharp venous recanalization procedures performed over an 11-month period and found Wallstent and Amplatzer vascular plug (AVP) targeting was performed in 16 patients...
June 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28607771/retrospective-study-of-vitreous-tap-technique-using-needle-aspiration-for-management-of-shallow-anterior-chamber-during-phacoemulsification
#14
Ashraf Ahmed Nossair, Wael Ahmed Ewais, Lamia Samy Ali
PURPOSE: To evaluate the technique of vitreous tap using needle aspiration for management of anterior chamber shallowness during phacoemulsification. METHODS: A retrospective study included 26 eyes of 17 patients who underwent phacoemulsification in which vitreous tap was performed using a 27-gauge needle attached to a 5 ml syringe, inserted 3.5 mm from the limbus to aspirate 0.2 ml of liquefied vitreous if a cohesive (OVD) failed to sufficiently deepen the anterior chamber...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28606611/bioinfra-prot-a-comprehensive-proteomics-workflow-including-data-standardization-protein-inference-expression-analysis-and-data-publication
#15
Michael Turewicz, Michael Kohl, Maike Ahrens, Gerhard Mayer, Julian Uszkoreit, Wael Naboulsi, Thilo Bracht, Dominik A Megger, Barbara Sitek, Katrin Marcus, Martin Eisenacher
The analysis of high-throughput mass spectrometry-based proteomics data must address the specific challenges of this technology. To this end, the comprehensive proteomics workflow offered by the de.NBI service center BioInfra.Prot provides indispensable components for the computational and statistical analysis of this kind of data. These components include tools and methods for spectrum identification and protein inference, protein quantification, expression analysis as well as data standardization and data publication...
June 9, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28604281/express-do-single-or-sequential-measurements-of-leptin-and-adiponectin-in-plasma-have-prognostic-value-in-pulmonary-arterial-hypertension
#16
Adriano R Tonelli, Wassim H Fares, Wael Dakkak, Youlan Rao, Xuan Zhou, Raed A Dweik
No abstract text is available yet for this article.
January 1, 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28602980/suppression-of-akt1-%C3%AE-catenin-pathway-in-advanced-prostate-cancer-promotes-tgf%C3%AE-1-mediated-epithelial-to-mesenchymal-transition-and-metastasis
#17
Fei Gao, Abdulrahman Alwhaibi, Harika Sabbineni, Arti Verma, Wael Eldahshan, Payaningal R Somanath
Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the genetic ablation or pharmacological inhibition of Akt1 in mice blunts oncogenic transformation and prostate cancer (PCa) growth. Intriguingly, triciribine (TCBN)-mediated Akt inhibition in 25-week old, tumor-bearing TRAMP mice and Akt1 gene silencing in aggressive PCa cells enhanced epithelial to mesenchymal transition (EMT) and promoted metastasis to the lungs...
June 7, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28601324/predictive-factors-for-recurrence-of-high-transsphincteric-anal-fistula-after-placement-of-seton
#18
Sameh Hany Emile, Hossam Elfeki, Waleed Thabet, Ahmed Sakr, Alaa Magdy, Tito M Abd El-Hamed, Waleed Omar, Wael Khafagy
BACKGROUND: The optimal surgical treatment for high transsphincteric fistula-in-ano (FIA) should attain complete eradication of the fistulous track and, in the same time, not compromising the anal sphincters. The present study aimed to investigate the predictive factors for recurrence of high transsphincteric FIA after placement of draining seton and to evaluate the efficacy and complications of seton treatment for high cryptoglandular anal fistula. MATERIALS AND METHODS: This is a retrospective case-control study of patients with high transsphincteric FIA who were treated with seton placement...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28596680/role-of-axl-in-invasion-and-drug-resistance-of-colon-and-breast-cancer-cells-and-its-association-with-p53-alterations
#19
Wael M Abdel-Rahman, Noura A Al-Khayyal, Vidhya A Nair, S R Aravind, Maha Saber-Ayad
AIM: To characterize AXL receptor tyrosine kinase (AXL) expression in relationship to tumor protein P53 (TP53 gene, p53 protein) and its role in tumor invasion and response to therapy. METHODS: We used 14 cell lines, including 3 isogenic pairs carrying mutant/knockout p53, to gain insight into the relationship between AXL and TP53. These included HCT116, HCT116.p53 mutant, RKO, and RKO.p53(-/-) lines (all from colon cancers) as well as breast cancer cell lines MCF7 and 1001 (MCF7-p53 mutant clone)...
May 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28594431/distinguishing-two-ammonium-and-a-triazolium-sites-of-interactions-in-a-three-station-2-rotaxane-molecular-shuttle
#20
Frédéric Coutrot, Philip Waelès, Karine Fournel-Marotte
In this paper, we report on the synthesis of a tri-stable [2]rotaxane molecular shuttle, in which the motion of the macrocycle is triggered by either specific protonation/deprotonation or specific carbamoylation/decarbamoylation of an alkylbenzylamine. The threaded axle is surrounded by a dibenzo[24]crown[8](DB24C8) and contains three sites of different affinities for the macrocycle. An Nmethyltriazolium acts as a molecular station of weak affinity for the DB24C8 and is located in the core of the encircled molecular axle...
June 8, 2017: Chemistry: a European Journal
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