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https://www.readbyqxmd.com/read/29775283/magnetic-glycol-chitin-based-hydrogel-nanocomposite-for-combined-thermal-and-d-amino-acid-assisted-biofilm-disruption
#1
Eric C Abenojar, Sameera Wickramasinghe, Minseon Ju, Sarika Uppaluri, Alison Klika, Jaiben George, Wael Barsoum, Salvatore J Frangiamore, Carlos A Higuera-Rueda, Anna Cristina S Samia
Bacterial biofilms are highly antibiotic resistant microbial cell associations that lead to chronic infections. Unlike free-floating planktonic bacterial cells, the biofilms are encapsulated in a hardly penetrable extracellular polymeric matrix and, thus, demand innovative approaches for treatment. Recent advancements on the development of gel-nanocomposite systems with tailored therapeutic properties provide promising routes to develop novel antimicrobial agents that can be designed to disrupt and completely eradicate preformed biofilms...
May 18, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29771156/achievement-of-low-density-lipoprotein-cholesterol-goals-in-18-countries-outside-western-europe-the-international-cholesterol-management-practice-study-iclps
#2
Nicolas Danchin, Wael Almahmeed, Khalid Al-Rasadi, Joseph Azuri, Abdelkrim Berrah, Carlos Alberto Cuneo, Yuri Karpov, Upendra Kaul, Meral Kayıkçıoğlu, Olena Mitchenko, Alvaro J Ruiz, Carlos A Aguilar Salinas, Raul D Santos, Florence Mercier, Dirk Blom
Background Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. Methods This cross-sectional observational study was conducted in 452 centres (August 2015-August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients ( n = 9049) treated for ≥3 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29767443/is-the-neonatal-tongue-screening-test-a-valid-and-reliable-tool-for-detecting-ankyloglossia-in-newborns
#3
Clarissa de Almeida Brandão, Mirian de Waele Souchois de Marsillac, Fernanda Barja-Fidalgo, Branca Heloisa Oliveira
BACKGROUND: Although there is a lack of strong evidence for the association between ankyloglossia in newborns and impaired breastfeeding, screening for ankyloglossia using the Neonatal Tongue Screening Test (NTST) is mandated by law in Brazilian maternities. AIM: To assess the reliability and validity of the NTST. DESIGN: cohort study; baseline sample comprised 268 mother-newborn dyads. At follow-up, 169 mothers were contacted by telephone...
May 16, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29766002/influence-of-vitamin-d-receptor-gene-polymorphisms-on-response-to-pegylated-interferon-in-chronic-hepatitis-b-egyptian-patients
#4
Gomaa Mostafa-Hedeab, Dina Sabry, Ghada Mostafa Abdelaziz, Manal Ewaiss, Nagla Adli, Wael Fathy
Background: We explored the effect of vitamin D receptor gene ( VDR ) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 µg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels and hepatitis B surface antigen (HBsAg) expression were assessed by ELISA. VDR polymorphisms FokI T>C (rs 10735810), BsmI A>G (rs 1544410), ApaI (rs7975253), and TaqI C>T (rs 731236), were genotyped using real-time PCR...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29759039/common-femoral-artery-endarterectomy-in-the-age-of-endovascular-therapy
#5
Mohamed Elsherif, Wael Tawfick, Mohamed Elsharkawi, Ruth Campell, Niamh Hynes, Sherif Sultan
Objectives Common femoral artery endarterectomy (CFE) is the standard treatment for common femoral artery occlusive disease. We aim to assess the medium term outcomes of CFE with or without further concomitant procedures. Design A retrospective observational study. Methods All patients who underwent either isolated CFE (ICFE), CFE with angioplasty for occlusive arterial disease (CFEA) or concomitant CFE with endovascular aortic aneurysm repair (CFEE) were included. Patient demographics follow up, clinical improvement, types of CFE closure, patency rates, and survival-free amputation were noted...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29756696/preliminary-experience-with-epidural-and-perineural-catheter-localization-with-pulsed-wave-doppler-ultrasonography
#6
Hesham Elsharkawy, Theresa Barnes, Rovnat Babazade, Maria Huarte, Wael Ali Sakr Esa, Brian M Ilfeld
BACKGROUND: Various methods for peripheral nerve and epidural catheter location assessment exist, with varying degrees of ease of use, utility, and accuracy. Pulsed wave Doppler (PWD) evaluates the presence of fluid flow and is possible modality to assess the location of a percutaneously inserted perineural catheter. METHODS: A retrospective chart review was conducted in which PWD ultrasonography was used to confirm the position of nerve catheters for regional anesthesia...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29755242/spinal-schistosomiasis-cases-in-egyptian-population
#7
Ahmed M Ashour, Tarek H Elserry, Mohamed S Nosser, Zeyad Y Fayed, Mohamed Wael Samir, Alaa Fakher, Maamoun M Ashour, Mamdouh M Salama
Background: Spinal cord involvement by schistosomiasis is considered to be rare. Clinical presentation of spinal schistosomiasis ranges from radicular pain to myelopathy causing flaccid paraplegia, bladder incontinence, and dysesthesia. We reported six cases with spinal schistosomiasis. Methodology: We did a retrospective analysis of the records in our department from March 1995 to March 2015, and we found that six cases of proved spinal schistosomiasis were documented, with follow-up period more than a year, aiming to find an assumption for a guideline for this ambiguous issue...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29755232/augmentation-of-fenestrated-pedicle-screws-with-cement-in-patients-with-osteoporotic-spine
#8
Mahmoud Abousayed, Joseph Gamal Boktor, Ahmed Maher Sultan, Wael Koptan, Yasser El-Miligui
Background: Backing out and failure of pedicle screws in patients with osteoporosis is becoming a big problem due to wide use of these screws nowadays. Purpose: The aim of this study is to evaluate the purchase of fenestrated pedicle screws augmented with cement in patients with osteoporosis. Study Design: This was retrospective observational study. Patients and Methods: From May 2015 to January 2016, 25 patients with a poor bone stock condition underwent posterior fixation by fenestrated pedicle screws and cement augmentation...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29752954/regulation-of-the-activins-follistatins-inhibins-axis-by-energy-status-impact-on-reproductive-function
#9
Nikolaos Perakakis, Jagriti Upadhyay, Wael Ghaly, Joyce Chen, Pavlina Chrysafi, Athanasios D Anastasilakis, Christos S Mantzoros
BACKGROUND: We have previously demonstrated that the adipose tissue derived hormone leptin controls reproductive function by regulating the hypothalamic-pituitary-gonadal axis in response to energy deficiency. Here, we evaluate the activins-follistatins-inhibins (AFI) axis during acute (short-term fasting in healthy people) and chronic energy deficiency (women with hypothalamic amenorrhea due to strenuous exercise [HA]) and investigate their relation to leptin and reproductive function in healthy subjects and subjects with HA...
May 9, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29747514/impact-of-clopidogrel-on-mortality-in-patients-with-acute-heart-failure-stratified-by-coronary-artery-disease-findings-from-the-arabian-gulf-acute-heart-failure-registry-gulf-care
#10
Ibrahim Al-Zakwani, Prashanth Panduranga, Jawad A Al-Lawati, Kadhim Sulaiman, Alawi A Alsheikh-Ali, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Omar Alnobani, Ahmed Al-Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al-Jarallah, Nooshin Bazargani, Nidal Asaad, Haitham Amin
We evaluated the impact of clopidogrel use on 3- and 12-months all-cause mortality in patients with acute heart failure (AHF) stratified by coronary artery disease (CAD) in patients admitted to 47 hospitals in 7 Middle Eastern countries with AHF from February to November 2012. Clopidogrel use was associated with significantly lower risk of all-cause mortality at 3 months (adjusted odds ratio [aOR], 0.61; 95% confidence interval [CI]: 0.42-0.87; P = .007) and 12 months (aOR, 0.61; 95% CI: 0.47-0.79; P < ...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29747397/field-efficacy-of-an-attenuated-infectious-bronchitis-variant-2-virus-vaccine-in-commercial-broiler-chickens
#11
Mohamed A Elhady, Ahmed Ali, Walid H Kilany, Wael K Elfeil, Hytham Ibrahim, Ahmed Nabil, Ahmed Samir, Magdy El Sayed
Egyptian poultry suffer from frequent respiratory disease outbreaks associated with Infectious Bronchitis Virus (IBV) variant 2 strains (Egy/VarII). Different vaccination programs using imported vaccines have failed to protect the flocks from field challenge. Recent studies confirmed a successful protection using homologous strains as live attenuated vaccines. In this study, a newly developed live attenuated IB-VAR2 vaccine representing the GI-23 Middle East IBV lineage was evaluated in day-old commercial broilers in an IBV-endemic area...
May 9, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29745342/novel-nicotinonitrile-derivatives-bearing-imino-moieties-enhance-apoptosis-and-inhibit-tyrosine-kinase
#12
Maher Elhashash, Eman El-Bordany, Magda Marzouk, Abeer ElSayed, Tarek Nawar, Wael El-Sayed
BACKGROUND: Fused heterocyclic containing pyrazolopyridine systems have several medicinal activities including cytotoxic and carcinostatic activities. OBJECTIVE: To investigate the antiproliferative activity and associated mechanism(s) of a novel series of nicotinonitrile derivatives. METHOD: The series has been synthesized by reaction of hydrazonoyl chlorides with each of 4-(4-methoxyphenyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile and 2-amino-4-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile in dioxane in basic medium...
May 9, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29742214/what-every-intensivist-should-know-about-the-management-of-peritonitis-in-the-intensive-care-unit
#13
Jan J De Waele
No abstract text is available yet for this article.
March 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29742117/tubulin-and-tau-possible-targets-for-diagnosis-of-parkinson-s-and-alzheimer-s-diseases
#14
Mohamed Salama, Ali Shalash, Alshimaa Magdy, Marianne Makar, Tamer Roushdy, Mahmoud Elbalkimy, Hanan Elrassas, Passent Elkafrawy, Wael Mohamed, Mohamed B Abou Donia
Neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by progressive neuronal loss and pathological accumulation of some proteins. Developing new biomarkers for both diseases is highly important for the early diagnosis and possible development of neuro-protective strategies. Serum antibodies (AIAs) against neuronal proteins are potential biomarkers for AD and PD that may be formed in response to their release into systemic circulation after brain damage...
2018: PloS One
https://www.readbyqxmd.com/read/29741867/tackling-poor-specificity-of-cocaine-color-tests-by-electrochemical-strategies
#15
Mats de Jong, Anca Florea, Joy Eliaerts, Filip Van Durme, Nele Samyn, Karolien De Wael
This paper presents electrochemical strategies for the fast screening of cocaine and most common cutting agents found in seized drug samples. First, a study on the performance of Scott color tests on cocaine and a wide range of cutting agents is described. The cutting agents causing false positive or false negative results when in mixture with cocaine are identified. To overcome the lack of specificity of color tests, we further propose a fast screening strategy by means of square wave voltammetry on disposable graphite screen printed electrodes, which reveals the unique fingerprint of cocaine and cutting agents...
May 9, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29741809/exogenous-il6-induces-mrna-splice-variant-mbd2_v2-to-promote-stemness-in-tp53-wild-type-african-american-pca-cells
#16
Emily A Teslow, Bin Bao, Greg Dyson, Christophe Legendre, Cristina Mitrea, Wael Sakr, John D Carpten, Isaac Powell, Aliccia Bollig-Fischer
African American men (AAM) are at higher risk of being diagnosed with prostate cancer (PCa) and are at higher risk of dying from the disease compared to European American men (EAM).We sought to better understand PCa molecular diversity that may be underlying these disparities. We performed RNA-sequencing analysis on high-grade PCa to identify genes showing differential tumor versus noncancer adjacent tissue expression patterns unique to AAM or EAM. We observed that interleukin-6 (IL6) was upregulated in the nonmalignant adjacent tissue in AAM, but in EAM IL6 expression was higher in PCa tissue...
May 9, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29741615/the-incidence-and-prognostic-implications-of-worsening-right-ventricular-function-after-surgical-or-transcatheter-aortic-valve-replacement-insights-from-partner-iia
#17
Paul C Cremer, Yiran Zhang, Maria Alu, L Leonardo Rodriguez, Brian R Lindman, Alan Zajarias, Rebecca T Hahn, Stamatios Lerakis, S Chris Malaisrie, Pamela S Douglas, Philippe Pibarot, Lars G Svensson, Martin B Leon, Wael A Jaber
Aims: In patients randomized to transcatheter or surgical aortic valve replacement (TAVR, SAVR), we sought to determine whether SAVR is associated with worsening right ventricular (RV) function and whether RV deterioration is associated with mortality. Methods and results: In 1376 patients from PARTNERIIA with paired baseline and 30-day core lab echocardiograms, worsening RV function was defined as decline by at least one grade from baseline to 30 days. Our primary outcome was all-cause mortality from 30 days to 2 years...
May 8, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29736649/does-nitrite-and-nitrate-levels-in-drinking-water-impact-the-health-of-people-in-dakahlia-governorate-egypt
#18
Wael I Mortada, Ahmed A Shokeir
A total of 1291 drinking water samples were examined for nitrite and nitrate during 6 months from December, 2015 to May, 2016 at 17 cities of Dakahlia governorate (Nile Delta, north of Egypt), and the results were utilized for assessment of health risk of the exposure from drinking water by calculating average daily intake (ADI), hazard quotient (HQ), and the hazard index (HI). The nitrite and nitrate in drinking water had a concentration range of 0.030-0.113 and 2.41-8.70 mg L-1 , with mean values of 0...
May 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29735566/protein-binding-of-first-line-antituberculous-drugs
#19
Wael A Alghamdi, Mohammad H Al-Shaer, Charles A Peloquin
INTRODUCTION: The 4-drug regimen of rifampin, isoniazid, pyrazinamide, and ethambutol is inexpensive, reliable option for treating patients with drug-susceptible tuberculosis (TB). Its efficacy could be further improved by determining the free drug concentrations in plasma, knowing that only the unbound drug can freely penetrate to the tissues. METHODS: Using an ultrafiltration technique, we determined the protein binding (PB) extent and variability of the first-line anti-TB drugs when given simultaneously to TB patients, representing a real-life case scenario...
May 7, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29735377/the-impact-of-solid-organ-transplant-history-on-inpatient-complications-mortality-length-of-stay-and-cost-for-primary-total-shoulder-arthroplasty-admissions-in-the-united-states
#20
Tennison L Malcolm, Kiran Chatha, Adam P Breceda, Eric Guo, Darren J Friedman, Vani J Sabesan, Wael K Barsoum
BACKGROUND: There is a growing population of patients with history of solid organ transplant (SOT) surgery among total joint patients. Patients with history of SOT have been found to have longer lengths of stay and higher inpatient hospital costs and complications rates after hip and knee arthroplasty. The purpose of this study was to determine whether this is true for shoulder arthroplasty in SOT patients. METHODS: The Nationwide Inpatient Sample was queried to describe relative demographic, hospital, and clinical characteristics, perioperative complications, length of stay, and total costs for patients with a history of SOT (International Classification of Diseases-9th Edition-Clinical Modificiation V42...
May 4, 2018: Journal of Shoulder and Elbow Surgery
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