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https://www.readbyqxmd.com/read/27914005/warm-heart-cold-liver
#1
Chonyang Albert, Robert Koeth, Wael Jaber
No abstract text is available yet for this article.
December 2, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27913519/transplantation-for-myelodysplastic-syndromes-who-when-and-which-conditioning-regimens
#2
Wael Saber, Mary M Horowitz
Allogeneic hematopoietic stem cell transplantation (HCT) is the only curative therapy for myelodysplastic syndrome (MDS). Broad application is hindered by high risks of transplant-related morbidity and mortality, especially in the older age range represented by the MDS population. However, recent advances in strategies to minimize regimen-related toxicity make HCT a viable option for many more patients. Appropriate selection of patients involves consideration of patient factors, including use of geriatric assessment tools and comorbidity scales, that predict risks of regimen-related toxicity as well as disease factors, including genetic markers, which predict survival with both non-HCT and HCT therapy...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913128/the-impact-of-solid-organ-transplant-history-on-inpatient-complications-mortality-length-of-stay-and-cost-for-primary-total-hip-arthroplasty-admissions-in-the-united-states
#3
Suparna M Navale, Caleb R Szubski, Alison K Klika, Nicholas K Schiltz, Pratik P Desai, Wael K Barsoum
BACKGROUND: As the prevalence of and life expectancy after solid organ transplantation increases, some of these patients will require total hip arthroplasty (THA). Immunosuppressive therapy, metabolic disorders, and post-transplant medications may place transplant patients at higher risk of adverse events following surgery. The objective of this study was to compare inpatient complications, mortality, length of stay (LOS), and costs for THA patients with and without solid organ transplant history...
November 10, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27908040/modeling-and-design-of-two-dimensional-membrane-type-active-acoustic-metamaterials-with-tunable-anisotropic-density
#4
Ahmed Allam, Adel Elsabbagh, Wael Akl
A two-dimensional active acoustic metamaterial with controllable anisotropic density is introduced. The material consists of composite lead-lead zirconate titanate plates clamped to an aluminum structure with air as the background fluid. The effective anisotropic density of the material is controlled, independently for two orthogonal directions, by means of an external static electric voltage signal. The material is used in the construction of a reconfigurable waveguide capable of controlling the direction of the acoustic waves propagating through it...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27903182/single-session-gamma-knife-radiosurgery-for-optic-pathway-hypothalamic-gliomas
#5
Amr M N El-Shehaby, Wael A Reda, Khaled M Abdel Karim, Reem M Emad Eldin, Ahmed M Nabeel
OBJECTIVE Because of their critical and central location, it is deemed necessary to fractionate when considering irradiating optic pathway/hypothalamic gliomas. Stereotactic fractionated radiotherapy is considered safer when dealing with gliomas in this location. In this study, the safety and efficacy of single-session stereotactic radiosurgery for optic pathway/hypothalamic gliomas were reviewed. METHODS Between December 2004 and June 2014, 22 patients with optic pathway/hypothalamic gliomas were treated by single-session Gamma Knife radiosurgery...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27900222/surgical-outcomes-and-complications-of-tube%C3%A2-promedon-malleable-penile-prostheses-in-diabetic-versus-non-diabetic-patients-with-erectile-dysfunction
#6
Elnisr Rashed Mohamed, Ahmed Rashed Hammady, Mohamed Zaki Eldahshoury, Ahmed Mamdouh Elsharkawi, Ahmed Mahmoud Riad, Hazem Mohamed Elmogazy, Mohamed Mostafa Hussien, Wael Mohamed Gamal
OBJECTIVE: To evaluate surgical outcome, complications, and patients satisfaction with the Tube® (Promedon, Cordoba, Argentina) malleable penile prosthesis in diabetic and non-diabetic patients with refractory erectile dysfunction (ED). PATIENTS AND METHODS: The records of 128 eligible patients who received Tube malleable penile prostheses at our institute between September 2008 and October 2015 were reviewed. RESULTS: Of the 128 patients, who received Tube penile prostheses at our institute, 53 were diabetics and 75 were non-diabetics...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27899955/comparison-between-standard-and-reduced-volume-radiotherapy-in-bladder-preservation-trimodality-protocol-for-muscle-invasive-bladder-cancer-patients
#7
Waleed Arafat, Azza Darwish, George E Naoum, Wael Sameh, Gamal El Husseiny, Fathy Abd-El-Gawad, Mostafa Samir
AIM: Our aim is to compare the toxicity, pelvic nodal relapse, and overall survival of whole bladder irradiation only to the standard technique of whole pelvis irradiation followed by bladder boost in patients with muscle-invasive bladder carcinoma undergoing bladder preservation protocol. MATERIAL AND METHOD: A total of 60 patients with transitional cell carcinoma, stage T2-3, N0, M0 bladder cancer were subjected to maximal transurethral resection bladder tumour (TURB)...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27899607/the-adenovirus-l4-22k-protein-regulates-transcription-and-rna-splicing-via-a-sequence-specific-single-stranded-rna-binding
#8
Susan Lan, Wael Kamel, Tanel Punga, Göran Akusjärvi
The adenovirus L4-22K protein both activates and suppresses transcription from the adenovirus major late promoter (MLP) by binding to DNA elements located downstream of the MLP transcriptional start site: the so-called DE element (positive) and the R1 region (negative). Here we show that L4-22K preferentially binds to the RNA form of the R1 region, both to the double-stranded RNA and the single-stranded RNA of the same polarity as the nascent MLP transcript. Further, L4-22K binds to a 5'-CAAA-3' motif in the single-stranded RNA, which is identical to the sequence motif characterized for L4-22K DNA binding...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27894776/design-synthesis-cyclooxygenase-inhibition-and-biological-evaluation-of-new-1-3-5-triaryl-4-5-dihydro-1h-pyrazole-derivatives-possessing-amino-methanesulfonyl-pharmacophore
#9
Khaled R A Abdellatif, Wael A A Fadaly
A new series of 1,3,5-triaryl-4,5-dihydro-1H-pyrazole 10a-l was designed and synthesized via cyclization of chalcones 8a-f with 4-amino/methanesulfonylphenylhydrazine hydrochloride 9a-b. All the synthesized compounds were evaluated for their cyclooxygenase (COX) inhibition, anti-inflammatory activity, ulcerogenic liability and analgesic activity. All compounds were more COX-2 inhibitors than COX-1. While most compounds showed good anti-inflammatory activity, the trimethoxy derivatives (10a, 10b, 10g and 10h) were the most potent derivatives (ED50=55...
November 21, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27891113/the-impact-of-silver-nanoparticles-produced-by-bacillus-pumilus-as-antimicrobial-and-nematicide
#10
Wael M Mahmoud, Tamer S Abdelmoneim, Ahmed M Elazzazy
This study evaluates the potential application of silver nanoparticles (AgNPs) as antimicrobial or nematicidal agents produced by the extremophile Bacillus pumilus, which was isolated from the alkaline Wadi El-Natrun Lake in Egypt. The AgNPs were characterized by ultraviolet-visible absorption spectroscopy, transmission electron microscopy, and energy dispersive x-ray spectroscopy. The size of AgNPs formed ranged from 20.12 to 29.48 nm. Panagrellus redivivus was exposed to different concentrations (0, 50, 100, 150, and 200 μg/mL) of AgNPs in a 5 mL nematode suspension (1 × 10(3) mL(-1))...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27888170/a-predictive-model-for-medical-events-based-on-contextual-embedding-of-temporal-sequences
#11
Wael Farhan, Zhimu Wang, Yingxiang Huang, Shuang Wang, Fei Wang, Xiaoqian Jiang
BACKGROUND: Medical concepts are inherently ambiguous and error-prone due to human fallibility, which makes it hard for them to be fully used by classical machine learning methods (eg, for tasks like early stage disease prediction). OBJECTIVE: Our work was to create a new machine-friendly representation that resembles the semantics of medical concepts. We then developed a sequential predictive model for medical events based on this new representation. METHODS: We developed novel contextual embedding techniques to combine different medical events (eg, diagnoses, prescriptions, and labs tests)...
November 25, 2016: JMIR Medical Informatics
https://www.readbyqxmd.com/read/27886822/ticagrelor-effects-beyond-the-p2y12-receptor
#12
REVIEW
Wael Sumaya, Robert F Storey
Platelet P2Y12 receptor inhibitors are crucial in the treatment of patients with acute coronary syndrome or undergoing percutaneous coronary intervention. Ticagrelor is a reversibly binding, potent oral P2Y12 inhibitor that also is a weak inhibitor of the equilibrative nucleoside transporter-1 pathway for cellular adenosine uptake. It is hypothesized that ticagrelor has clinically relevant "off-target" effects, independent of its effect on platelet aggregation and thrombosis. This review considers the pleiotropic effects of ticagrelor and some of the possible mechanisms related to these effects...
January 2017: Interventional cardiology clinics
https://www.readbyqxmd.com/read/27886257/an-evolutionary-conserved-interaction-between-the-gcm-transcription-factor-and-the-sf1-nuclear-receptor-in-the-female-reproductive-system
#13
Pierre B Cattenoz, Claude Delaporte, Wael Bazzi, Angela Giangrande
NR5A1 is essential for the development and for the function of steroid producing glands of the reproductive system. Moreover, its misregulation is associated with endometriosis, which is the first cause of infertility in women. Hr39, the Drosophila ortholog of NR5A1, is expressed and required in the secretory cells of the spermatheca, the female exocrine gland that ensures fertility by secreting substances that attract and capacitate the spermatozoids. We here identify a direct regulator of Hr39 in the spermatheca: the Gcm transcription factor...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884719/systematic-review-and-meta-analysis-of-randomised-controlled-trials-on-the-effectiveness-of-school-based-dental-screening-versus-no-screening-on-improving-oral-health-in-children
#14
REVIEW
Easter Joury, Eduardo Bernabe, Wael Sabbah, Kamal Nakhleh, Kurinchi Gurusamy
OBJECTIVES: The current study aimed to evaluate the effectiveness of school-based dental screening versus no screening on improving oral health in children aged 3-18 years by a systematic review and meta-analysis of randomised controlled trials. SOURCES AND STUDY SELECTION: Three sets of independent reviewers searched MEDLINE, EMBASE, Web of Science and other sources through April 2016 to identify published and nonpublished studies without language restrictions and extracted data...
November 22, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27884628/skirt-followed-by-trouser-stenting-technique-true-anatomical-preservation-of-coronary-y-shaped-bifurcation-lesions-while-using-vanishing-bioresorbable-scaffolds-a-report-of-two-cases
#15
Wael Elabbassi, Arif Al Nooryani
We report on two cases in which Y-shaped coronary bifurcations were treated with the use of Bioresorbable scaffolds. The first case was of a 50-year-old man with NSTEMI. Coronary angiography showed stenosis involving a Y-shaped bifurcation of proximal to mid LAD and diagonal. The lesion was wired using two 0.14 BMW guide wires, followed by serial pre-dilatation of LAD and Diagonal branch. The stent into proximal LAD was deployed first as a skirt (3.5 × 12 BVS). Stent was post-dilated. A second 2.5 × 28 BVS was deployed into diagonal branch, protruding backwards; along with a 2...
November 3, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27882813/dietary-zinc-modifies-diabetic-induced-renal-pathology-in-rats
#16
Wael M Elsaed, Hazem Abdelhamid Mohamed
This study was conducted to investigate how far dietary zinc (Zn) modifies the histomorphological alterations induced by diabetes in rat kidneys. The animals were divided into negative control group (10 rats). Diabetes was induced in thirty animals by streptozotocin. After confirming diabetes, the animals were divided into three groups (n = 10). Group II served as the positive control group (fed on standard diet), group III was fed on Zn deficient diet, and group IV was fed on Zn supplemented diet. Caspase-3 immune staining was used to estimate the caspase activity...
November 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27878049/prostate-volume-estimations-using-magnetic-resonance-imaging-and-transrectal-ultrasound-compared-to-radical-prostatectomy-specimens
#17
Nicholas R Paterson, Luke T Lavallée, Laura N Nguyen, Kelsey Witiuk, James Ross, Ranjeeta Mallick, Wael Shabana, Blair MacDonald, Nicola Scheida, Dean Fergusson, Franco Momoli, Sonya Cnossen, Christopher Morash, Ilias Cagiannos, Rodney H Breau
INTRODUCTION: We sought to evaluate the accuracy of prostate volume estimates in patients who received both a preoperative transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI) in relation to the referent pathological specimen post-radical prostatectomy. METHODS: Patients receiving both TRUS and MRI prior to radical prostatectomy at one academic institution were retrospectively analyzed. TRUS and MRI volumes were estimated using the prolate ellipsoid formula...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27876945/a-case-of-fatal-gastrointestinal-haemorrhage-due-to-hyperinfection-with-strongyloides-stercoralis
#18
Dina Abdallah Zaghlool, Amal Ali Hassan, Asmaa Moustafa Moustafa, Wael Ahmed Shahin
Strongyloides stercoralis is an intestinal nematode with a complex life cycle. It is usually asymptomatic in healthy host however it may be a life threatening condition in immunocompromised patients when hyperinfection is associated with disseminated disease. However, reports of gastric involvement are rare. This is a case report of fatal gastrointestinal hemorrhage due to hyperinfection with S. stercoralis in a Burmawi male patient after brief corticosteroid therapy.
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27873287/non-invasive-and-non-destructive-examination-of-artistic-pigments-paints-and-paintings-by-means-of-x-ray-methods
#19
REVIEW
Koen Janssens, Geert Van der Snickt, Frederik Vanmeert, Stijn Legrand, Gert Nuyts, Matthias Alfeld, Letizia Monico, Willemien Anaf, Wout De Nolf, Marc Vermeulen, Jo Verbeeck, Karolien De Wael
Recent studies are concisely reviewed, in which X-ray beams of (sub)micrometre to millimetre dimensions have been used for non-destructive analysis and characterization of pigments, minute paint samples, and/or entire paintings from the seventeenth to the early twentieth century painters. The overview presented encompasses the use of laboratory and synchrotron radiation-based instrumentation and deals with the use of several variants of X-ray fluorescence (XRF) as a method of elemental analysis and imaging, as well as with the combined use of X-ray diffraction (XRD) and X-ray absorption spectroscopy (XAS)...
December 2016: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/27871749/the-effects-of-metallic-engineered-nanoparticles-upon-plant-systems-an-analytic-examination-of-scientific-evidence
#20
Thabet Tolaymat, Ash Genaidy, Wael Abdelraheem, Dionysios Dionysiou, Christian Andersen
Recent evidence for the effects of metallic engineered nanoparticles (ENPs) on plants and plant systems was examined together with its implications for other constituents of the Society-Environment-Economy (SEE) system. In this study, we were particularly interested to determine whether or not metallic ENPs have both stimulatory and inhibitory effects upon plant performance. An emphasis was made to analyze the scientific evidence on investigations examining both types of effects in the same studies. Analysis of evidence demonstrated that metallic ENPs have both stimulatory and inhibitory effects mostly in well-controlled environments and soilless media...
November 18, 2016: Science of the Total Environment
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