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https://www.readbyqxmd.com/read/28096091/use-of-hematopoietic-cell-transplantation-for-patients-with-myelodysplastic-syndrome-and-chronic-myelomonocytic-leukemia
#1
Theo de Witte, David Bowen, Marie Robin, Luca Malcovati, Dietger Niederwieser, Ibrahim Yakoub-Agha, Ghulam J Mufti, Pierre Fenaux, Guillermo Sanz, Rodrigo Martino, Emilio Paolo Alessandrino, Francesco Onida, Argiris Symeonidis, Jakob Passweg, Guido Kobbe, Arnold Ganser, Uwe Platzbecker, Jürgen Finke, Michel van Gelder, Arjan A van de Loosdrecht, Per Ljungman, Reinhard Stauder, Liisa Volin, H Joachim Deeg, Corey Cutler, Wael Saber, Richard Champlin, Sergio Giralt, Claudio Anasetti, Nicolaus Kröger
No abstract text is available yet for this article.
January 17, 2017: Blood
https://www.readbyqxmd.com/read/28088621/4-hydroxynonenal-causes-impairment-of-human-subcutaneous-adipogenesis-and-induction-of-adipocyte-insulin-resistance
#2
Mohamed A Elrayess, Shamma Almuraikhy, Wael Kafienah, Afnan Al-Menhali, Fatima Al-Khelaifi, Moataz Bashah, Kamelija Zarkovic, Neven Zarkovic, Georg Waeg, Mohammed Alsayrafi, Morana Jaganjac
OBJECTIVE: Increased adipose production of 4-hydroxynonenal (4-HNE), a bioreactive aldehyde, directly correlates with obesity and insulin resistance. The aim of this study was to elucidate the impact of 4-HNE in mediating adipocyte differentiation and function in two metabolically distinct obese groups; the insulin sensitive (IS) and the insulin resistant (IR). METHODS: Subcutaneous (SC) adipose tissues were obtained from eighteen clinically well characterized obese premenopausal women undergoing weight reduction surgery...
January 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28077439/the-functional-expression-of-transient-receptor-potential-channels-in-the-mouse-endometrium
#3
Katrien De Clercq, Charlotte Van den Eynde, Aurélie Hennes, Rieta Van Bree, Thomas Voets, Joris Vriens
STUDY QUESTION: Does mouse endometrial epithelial cells and stromal cells have a similar transient receptor potential (TRP)-channel expression profile and to that found in the human endometrium? SUMMARY ANSWER: Mouse endometrial epithelial and stromal cells have a distinct TRP channel expression profile analogous to what has been found in human endometrium, and hence suggests the mouse a good model to investigate the role of TRP channels in reproduction. WHAT IS KNOWN ALREADY: An optimal intercellular communication between epithelial and stromal endometrial cells is crucial for successful reproduction...
January 6, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28073841/activation-of-eif4e-by-aurora-kinase-a-depicts-a-novel-druggable-axis-in-everolimus-resistant-cancer-cells
#4
Ahmed Katsha, Lihong Wang, Janet Arras, Omar M Omar, Jeffrey A Ecsedy, Abbes Belkhiri, Wael El-Rifai
PURPOSE: In this study, we investigated the role of Aurora kinase A (AURKA) in regulating EIF4E, cap-dependent translation, and resistance to mTOR inhibitor, RAD001 (everolimus). EXPERIMENTAL DESIGN: Tumor xenografts and in vitro cell models of upper gastrointestinal adenocarcinomas (UGCs) were used to determine the role of AURKA in activation of EIF4E and cap-dependent translation. Overexpression, knockdown, and pharmacologic inhibition of AURKA were used in vitro and in vivo...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28073568/three-mechanisms-of-early-failure-of-transcatheter-aortic-valves-valve-thrombosis-cusp-rupture-and-accelerated-calcification
#5
Matthew R Summers, Paul C Cremer, Wael A Jaber
No abstract text is available yet for this article.
December 14, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28073286/bipolar-plasmakinetic-enucleo-resection-of-the-prostate-our-exp%C3%A3-rience-with-245-patients-for-3-years-of-follow-up
#6
Ahmed Abou-Taleb, Waleed El-Shaer, Wael Saber, Tarek Gharib, Alaa Elshaer
OBJECTIVE: the aim of this study was to evaluate the safety, feasibility and effectiveness of bipolar transurethral plasmakinetic enucleation of the prostate (PKEP). PATIENTS AND METHOD: Between January 2010 and October 2013, 245 patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) underwent transurethral enucleation of prostate using bipolar plasma vaporization energy. They were evaluated pre-operatively by Full detailed history, examination especially digital rectal examination (DRE), routine pre-operative investigation, serum prostate-specific antigen (PSA), abdominal and trans-rectal ultrasonography (US) and Maximum flow rates (Qmax)...
January 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28063585/extraneous-fibre-traces-brought-by-river-water-a-case-study
#7
L Lepot, T Vanden Driessche, K Lunstroot, A Barret, F Gason, K De Wael
The fibre traces on a young victim found underwater were mostly single fibre traces besides small amounts of fibre collectives indistinguishable from his parents clothes (mainly wool). Most of those single fibre traces were blue-grey polyester fibres showing tiny differences among each other. They were unexpected according to known population fibre studies. One year after the victim's discovery experiments were conducted to evaluate the possible contamination with fibres from river water. A small amount of extraneous fibres were collected among which blue and grey-black cotton and man-made (mainly polyester) fibres...
January 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28060131/nonfunctioning-adrenocortical-carcinoma-in-pediatric-acute-lymphoblastic-leukemia-a-case-report-of-a-rare-multiple-primaries-combination
#8
Wafaa M Rashed, Wael Zekri, Madiha Awad, Hala Taha, Badr Abdalla, Ahmad S Alfaar
Childhood adrenocortical carcinoma (ACC) is a rare tumor and its association with acute lymphoblastic leukemia (ALL) is even rarer. One such case is discussed in this case report. A 3-year-old patient was concomitantly diagnosed with ALL and an initially nonmetastatic ACC. Management started by following the Total XV protocol without a window phase. Left adrenalectomy was conducted after the consolidation phase. Recurrence of a mass at the tumor bed was discovered at week 33 of the continuation phase. Reexcision was conducted, followed by the administration of an ACC protocol including cisplatin, etoposide, and doxirubicin...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28054327/obesity-epidemic-is-its-impact-on-total-joint-arthroplasty-underestimated-an-analysis-of-national-trends
#9
Jaiben George, Alison K Klika, Suparna M Navale, Jared M Newman, Wael K Barsoum, Carlos A Higuera
BACKGROUND: Obesity is a well-established risk factor for total joint arthroplasty (TJA) and a number of complications including prosthetic joint infection. The annual changes in the prevalence of obesity among primary, revision, and infected TJA has not been studied at a national level. Given the higher costs of complications of TJA, it is important to understand the association of obesity with the annual trends of revision and infected TJA. QUESTIONS/PURPOSES: (1) Is the prevalence of obesity increasing among patients undergoing THA/TKA? (2) Is the prevalence of obesity increasing among patients undergoing revision THA/TKA? (3) Is the prevalence of obesity increasing among patients with infected THA/TKA? METHODS: Annual volumes of primary, revision, and infected THA and TKA from 1998 to 2011 were obtained from the Nationwide Inpatient Sample...
January 4, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28052097/the-natural-flavonoid-fisetin-inhibits-cellular-proliferation-of-hepatic-colorectal-and-pancreatic-cancer-cells-through-modulation-of-multiple-signaling-pathways
#10
Mаhmoud Youns, Wael Abdel Halim Hegazy
Digestive cancers are major causes of mortality and morbidity worldwide. Fisetin, a naturally occurring flavonoid, has been previously shown anti-proliferative, anti-cancer, neuroprotective, and antioxidant activities. In our study, the anti-tumor activities in addition to regulatory effects of fisetin on some cancer cell lines were investigated. Data presented here showed that fisetin induces growth inhibition, and apoptosis in hepatic (HepG-2), colorectal (Caco-2) and pancreatic (Suit-2) cancer cell lines...
2017: PloS One
https://www.readbyqxmd.com/read/28052035/brca1-iris-overexpression-promotes-and-maintains-the-tumor-initiating-phenotype-implications-for-triple-negative-breast-cancer-early-lesions
#11
Abhilasha Sinha, Bibbin T Paul, Lisa M Sullivan, Hillary Sims, Ahmed El Bastawisy, Hend F Yousef, Abdel-Rahman N Zekri, Abeer A Bahnassy, Wael M ElShamy
Tumor-initiating cells (TICs) are cancer cells endowed with self-renewal, multi-lineage differentiation, increased chemo-resistance, and in breast cancers the CD44+/CD24-/ALDH1+ phenotype. Triple negative breast cancers show lack of BRCA1 expression in addition to enhanced basal, epithelial-to-mesenchymal transition (EMT), and TIC phenotypes. BRCA1-IRIS (hereafter IRIS) is an oncogene produced by the alternative usage of the BRCA1 locus. IRIS is involved in induction of replication, transcription of selected oncogenes, and promoting breast cancer cells aggressiveness...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28051226/erectile-dysfunction-secondary-to-pudendal-nerve-injury-on-orthopaedic-table
#12
Sahbi Naouar, Wael Majdoub, Salem Braiek, Rafik El Kamel
No abstract text is available yet for this article.
June 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28050864/technetium-pyrophosphate-uptake-in-transthyretin-cardiac-amyloidosis-associations-with-echocardiographic-disease-severity-and-outcomes
#13
Michael N Vranian, Brett W Sperry, Mazen Hanna, Rory Hachamovitch, Asad Ikram, Richard C Brunken, Wael A Jaber
BACKGROUND: Quantitative uptake of Technetium 99 m-pyrophosphate (TcPYP) is sensitive and specific for diagnosing transthyretin cardiac amyloidosis (ATTR). We sought to examine the association between TcPYP uptake intensity and echocardiographic measures of disease severity and clinical outcomes. METHODS AND RESULTS: A retrospective analysis was performed of 75 patients who underwent TcPYP scintigraphy. Planar images were evaluated semiquantitatively and using heart-to-contralateral lung (H/CL) ratio...
January 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28050498/evaluation-of-low-level-laser-therapy-on-pain-perception-following-orthodontic-elastomeric-separation-a-randomized-controlled-trial
#14
Mai M E Almallah, Wael H Almahdi, Mohammad Y Hajeer
INTRODUCTION: Periodontal pain caused by elastomeric separators is a very common problem in the commencement of orthodontic treatment. Previous studies have shown good results in reducing this pain by Low Level Laser Therapy (LLLT) and different protocols of application have been suggested in the literature. AIM: This trial aimed to evaluate LLLT on managing orthodontic pain caused by elastomeric separators and to compare single versus double irradiation in possible pain reduction...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049169/management-of-stage-i-and-ii-nonsmall-cell-lung-cancer
#15
Fiona McDonald, Michèle De Waele, Lizza E L Hendriks, Corinne Faivre-Finn, Anne-Marie C Dingemans, Paul E Van Schil
The incidence of stage I and II nonsmall cell lung cancer is likely to increase with the ageing population and introduction of screening for high-risk individuals. Optimal management requires multidisciplinary collaboration. Local treatments include surgery and radiotherapy and these are currently combined with (neo)adjuvant chemotherapy in specific cases to improve long-term outcome. Targeted therapies and immunotherapy may also become important therapeutic modalities in this patient group. For resectable disease in patients with low cardiopulmonary risk, complete surgical resection with lobectomy remains the gold standard...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28045232/corrigendum-a-unique-tryptophan-c-prenyltransferase-from-the-kawaguchipeptin-biosynthetic-pathway
#16
Anirudra Parajuli, Daniel H Kwak, Luca Dalponte, Niina Leikoski, Tomas Galica, Ugochukwu Umeobika, Laurent Trembleau, Andrew Bent, Kaarina Sivonen, Matti Wahlsten, Hao Wang, Ermanno Rizzi, Gianluca De Bellis, James Naismith, Marcel Jaspars, Xinyu Liu, Wael Houssen, David Peter Fewer
No abstract text is available yet for this article.
January 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28043480/the-integrated-comprehensive-care-program-a-novel-home-care-initiative-after-major-thoracic-surgery
#17
Yaron Shargall, Wael C Hanna, Laura Schneider, Colin Schieman, Christian J Finley, Anna Tran, Shantel Demay, Carolyn Gosse, James M Bowen, Gord Blackhouse, Kevin Smith
The objective of the study was to evaluate the Integrated Comprehensive Care (ICC) program, a novel health system integration initiative that coordinates home care and hospital-based clinical services for patients undergoing major thoracic surgery relative to traditional home care delivery. Methods included a pilot retrospective cohort analysis that compared the intervention cohort (ICC), composed of all patients undergoing major thoracic surgery in the 2012-2013 fiscal year with a control cohort, who underwent surgery in the year before the initiation of ICC...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28043113/long-term-outcome-of-the-retrourethral-transobturator-male-sling-after-transurethral-resection-of-the-prostate
#18
Alexander Kretschmer, Alexander Buchner, Benedikt Leitl, Markus Grabbert, Anne Sommer, Wael Khoder, Christian Gozzi, Christian G Stief, Ricarda M Bauer
PURPOSE: To evaluate long-term outcomes of AdVance and AdVanceXP male slings in patients with persistent stress urinary incontinence (SUI) after transurethral resection of the prostate (TURP). METHODS: A total of 18 consecutive patients received AdVance (n=14) or AdVanceXP (n=4) male sling implantation between 2007 and 2013. Continence was determined by pad use, 24-hour pad testing and validated questionnaires (International Consultation on Incontinence Questionnaire Short Form, ICIQ-SF)...
December 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/28041948/pre-stimulus-alpha-oscillations-over-somatosensory-cortex-predict-tactile-misperceptions
#19
Matt Craddock, Ellen Poliakoff, Wael El-Deredy, Ekaterini Klepousniotou, Donna M Lloyd
Fluctuations of pre-stimulus oscillatory activity in the somatosensory alpha band (8-14Hz) observed using human EEG and MEG have been shown to influence the detection of supra- and peri-threshold somatosensory stimuli. However, some reports of touch occur even without a stimulus. We investigated the possibility that pre-stimulus alpha oscillations might also influence these false reports of touch - known as tactile misperceptions. We recorded EEG while participants performed the Somatic Signal Detection Task (SSDT), in which participants must detect brief, peri-threshold somatosensory targets...
December 29, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/28039018/estrogen-regulated-stat1-activation-promotes-tlr8-expression-to-facilitate-signaling-via-microrna-21-in-systemic-lupus-erythematosus
#20
Nicholas A Young, Giancarlo R Valiente, Jeffrey M Hampton, Lai-Chu Wu, Craig J Burd, William L Willis, Michael Bruss, Holly Steigelman, Maya Gotsatsenko, Stephanie A Amici, Mary Severin, Lucila Marino Claverie, Mireia Guerau-de-Arellano, Amy Lovett-Racke, Stacy Ardoin, Wael N Jarjour
Recent studies implicate innate immunity to systemic lupus erythematosus (SLE) pathogenesis. Toll-like receptor (TLR)8 is estrogen-regulated and binds viral ssRNA to stimulate innate immune responses, but recent work indicates that microRNA (miR)-21 within extracellular vesicles (EVs) can also trigger this receptor. Our objective was to examine TLR8 expression/activation to better understand sex-biased responses involving TLR8 in SLE. Our data identify an estrogen response element that promotes STAT1 expression and demonstrate STAT1-dependent transcriptional activation of TLR8 with estrogen stimulation...
December 27, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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