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https://www.readbyqxmd.com/read/28547948/cytokeratin-18-in-diagnosis-of-hcc-in-patients-with-liver-cirrhosis
#1
Saber A Ismail, Sherif El Saadany, Dina H Ziada, Soha S Zakaria, Wael W Mayah, Heba Elashry, Mona Arafa, Nehal Elmashad
Background: Hepatocellular carcinoma (HCC) is a common malignancy that occurs secondary to viral hepatitis B and C cirrhosis under the influence of environmental factors. In early stages, clinical diagnosis is often difficult and distinguishing HCC from cirrhosis and other hepatic masses by conventional tests is frequently not feasible. Physicians usually depend on measuring serum alpha-fetoprotein (AFP), but this marker has low sensitivity and specificity. The aim of this research was to determine any role of serum cytokeratin-18(Ck-18) as a marker for diagnosis of HCC in patients with liver cirrhosis...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28547669/cardiovascular-disease-in-the-literature-a-selection-of-recent-original-research-papers
#2
REVIEW
Fadi G Hage, Wael AlJaroudi
No abstract text is available yet for this article.
May 25, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28546041/10-years-single-centre-results-of-abdominal-aortic-aneurysm-treatment-endovascular-vs-open-repair
#3
Payman Majd, Wael Ahmad, Ingrid Becker, Jan Sigge Brunkwall
OBJECTIVES: The purpose of the present study was to compare the long-term survival in matched cohorts of patients with infrarenal abdominal aortic aneurysm (AAA) undergoing an elective open repair (OR) or an endovascular aneurysm repair (EVAR). MATERIALS AND METHODS: Patients with a primary elective repair of an infrarenal aortic aneurysm between 1998 and 2006 were identified in a retrospective review of our single centre database. EVAR and OR patients were matched with respect to age, gender, renal disease, tobacco use, hypertension, chronic obstructive pulmonary disease and coronary artery disease...
May 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28542273/expression-profile-of-epstein-barr-virus-and-human-adenovirus-small-rnas-in-tonsillar-b-and-t-lymphocytes
#4
Farzaneh Assadian, Wael Kamel, Göran Laurell, Catharina Svensson, Tanel Punga, Göran Akusjärvi
We have used high-throughput small RNA sequencing to characterize viral small RNA expression in purified tonsillar B and T lymphocytes isolated from patients tested positive for Epstein-Barr virus (EBV) or human adenovirus (HAdV) infections, respectively. In the small set of patients analyzed, the expression profile of EBV and HAdV miRNAs could not distinguish between patients diagnosed with tonsillar hypertrophy or chronic/recurrent tonsillitis. The EBV miR-BART expression profile among the patients diagnosed with tonsillar diseases resembles most closely the pattern seen in EBV+ tumors (Latency II/I)...
2017: PloS One
https://www.readbyqxmd.com/read/28541047/multitargeted-flavonoid-inhibition-of-the-pathogenic-bacterium-staphylococcus-aureus-a-proteomic-characterization
#5
Wael A Elmasri, Rui Zhu, Wenjing Peng, Moustafa Al-Hariri, Firas Kobeissy, Phat Tran, Abdul N Hamood, Mohamed F Hegazy, Paul W Paré, Yehia Mechref
Growth inhibition of the pathogen Staphylococcus aureus with currently available antibiotics is problematic in part due to bacterial biofilm protection. Although recently characterized natural products, including 3',4',5-trihydroxy-6,7-dimethoxy-flavone [1], 3',4',5,6,7-pentahydroxy-flavone [2], and 5-hydroxy-4',7-dimethoxy-flavone [3], exhibit both antibiotic and biofilm inhibitory activities, the mode of action of such hydroxylated flavonoids with respect to S. aureus inhibition is yet to be characterized...
May 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28539924/therapeutic-development-of-mesenchymal-stem-cells-or-their-extracellular-vesicles-to-inhibit-autoimmune-mediated-inflammatory-processes-in-systemic-lupus-erythematosus
#6
REVIEW
Juhi Sharma, Jeffrey M Hampton, Giancarlo R Valiente, Takuma Wada, Holly Steigelman, Matthew C Young, Rachel R Spurbeck, Alisa D Blazek, Steffi Bösh, Wael N Jarjour, Nicholas A Young
Since being discovered over half a century ago, mesenchymal stem cells (MSCs) have been investigated extensively to characterize their cellular and physiological influences. MSCs have been shown to possess immunosuppressive capacity through inhibiting lymphocyte activation/proliferation and proinflammatory cytokine secretion while simultaneously demonstrating limited allogenic reactivity, which subsequently led to the evaluation of therapeutic feasibility to treat inflammatory diseases. Although regulatory constraints have restricted MSC development pharmacologically, limited clinical studies have shown encouraging results using MSC infusions to treat systemic lupus erythematosus (SLE); but, more trials will have to be performed to conclusively determine the clinical efficacy of MSCs to treat SLE...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28537354/the-use-of-transcutaneous-electrical-nerve-stimulation-after-total-knee-arthroplasty-a-prospective-randomized-controlled-trial
#7
Deepak Ramanathan, Anas Saleh, Alison K Klika, Carlos A Higuera, Wael K Barsoum
INTRODUCTION: Multimodal pain management is used after total knee arthroplasty (TKA) to reduce opioid intake. Transcutaneous electrical nerve stimulation (TENS) has generated much interest as a non-pharmacologic, patient-controlled therapy. The aims of this study were to evaluate the efficacy of TENS in reducing opioid intake and improving recovery after TKA. MATERIALS AND METHODS: This was a prospective, parallel-group, double-blinded, randomized trial of patients receiving femoral nerve catheter block with allocation to either active or placebo TENS device groups...
May 24, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28535751/socioeconomic-inequality-in-clusters-of-health-related-behaviours-in-europe-latent-class-analysis-of-a-cross-sectional-european-survey
#8
Shiho Kino, Eduardo Bernabé, Wael Sabbah
BACKGROUND: Modifiable health-related behaviours tend to cluster among most vulnerable sectors of the population, particularly those at the bottom of the social hierarchy. This study aimed to identify the clusters of health-related behaviours in 27 European countries and to examine the socioeconomic inequalities in these clusters. METHODS: Data were from Eurobarometer 72.3-2009, a cross-sectional survey of 27 European countries. The analyses were conducted in 2016...
May 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28534806/feature-selection-for-nonstationary-data-application-to-human-recognition-using-medical-biometrics
#9
Majid Komeili, Wael Louis, Narges Armanfard, Dimitrios Hatzinakos
Electrocardiogram (ECG) and transient evoked otoacoustic emission (TEOAE) are among the physiological signals that have attracted significant interest in biometric community due to their inherent robustness to replay and falsification attacks. However, they are time-dependent signals and this makes them hard to deal with in across-session human recognition scenario where only one session is available for enrollment. This paper presents a novel feature selection method to address this issue. It is based on an auxiliary dataset with multiple sessions where it selects a subset of features that are more persistent across different sessions...
May 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28534190/a-prospective-randomised-comparison-between-the-transperitoneal-and-retroperitoneoscopic-approaches-for-robotic-assisted-pyeloplasty-in-a-single-surgeon-single-centre-study
#10
Wael Y Khoder, Raphaela Waidelich, Abdel Majeed Al Ghamdi, Therese Schulz, Armin Becker, Christian G Stief
Literature data comparing robotic-assisted laparoscopic versus retroperitoneoscopic approaches are still lacking, probably due to difficulties with the retroperitoneoscopic approach. The objective is to compare the results of robotic-assisted pyeloplasty using transperitoneal and retroperitoneal approaches in a prospective randomised single surgeon study. 80 consecutive patients with primary ureteropelvic junction obstruction were prospectively randomised between transperitoneal (40 patients, group 1) and retroperitoneal (40 patients, group 2) robotic-assisted pyeloplasty...
May 22, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28516111/transhiatal-herniation-of-the-pancreas-a-rare-cause-of-acute-pancreatitis
#11
Jeremy Wang, Adarsh M Thaker, Wael Noor El-Nachef, Rabindra R Watson
Transhiatal herniation of the pancreas is rare. Acute pancreatitis secondary to this phenomenon is particularly unusual. A 102-year-old woman presented with 1 day of severe chest pain, vomiting, dyspnea, and diaphoresis. Serum lipase was elevated, and computed tomography angiogram of the chest and magnetic resonance cholangiopancreatography revealed a hiatal hernia containing the pancreas, with associated findings of pancreatitis. Pancreatitis in this setting may be due to repetitive trauma or ischemia from sliding, intermittent folding of the pancreatic duct, or pancreatic incarceration...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28514767/glutathione-peroxidase-7-suppresses-cancer-cell-growth-and-is-hypermethylated-in-gastric-cancer
#12
Zheng Chen, Tianling Hu, Shoumin Zhu, Kenichi Mukaisho, Wael El-Rifai, Dun-Fa Peng
Gastric cancer (GC) is one of the most common cancers in the world, and remains the third leading cause of cancer-related deaths worldwide. Glutathione peroxidase 7 (GPX7) is a member of GPX family which is downregulated in some cancer types. In this study, we investigated the expression, regulation, and molecular function of GPX7 in gastric cancer using 2D and 3D in vitro models and de-identified human tissue samples. Quantitative real-time RT-PCR, immunofluorescence, Western blot, 3D organotypic cultures, and pyrosequencing assays were used...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512581/refractive-lens-exchange-combined-with-primary-posterior-vitrectorhexis-in-highly-myopic-patients
#13
Tarek A Mohamed, Wael Soliman, Dalia M El Sebaity, Ahmed M Fathalla
Purpose. To evaluate efficacy and safety of primary vitrectorhexis for posterior capsulotomy in highly myopic patients undergoing refractive lens exchange. Methods. The study is a prospective nonrandomized interventional study. The study comprised 60 eyes of 60 myopic patients. All patients underwent refractive lens exchange (RLE) and foldable IOL implantation combined with primary posterior capsulotomy. We used a 23-gauge vitrectomy probe for the creation of the posterior capsule opening. We followed the patients for one year...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28506664/heliox-delivered-by-high-flow-nasal-cannula-improves-oxygenation-in-infants-with-respiratory-syncytial-virus-acute-bronchiolitis
#14
Wael Seliem, Amira M Sultan
OBJECTIVE: The objective of this study is to evaluate the hypothesis that use of heliox would result in improvement of gas exchange when used with high flow nasal cannula in infants with RSV acute bronchiolitis. METHODS: All patients that met the inclusion criteria were randomized to either heliox (70:30) or air-oxygen mixture 30% via high flow nasal cannula at 8L/min for a continuous 24h. Measurements were taken at baseline, after 2h, and at the end of the 24h...
May 12, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28503064/combined-intrastromal-injection-of-amphotericin-b-and-topical-fluconazole-in-the-treatment-of-resistant-cases-of-keratomycosis-a-retrospective-study
#15
Waled Mahdy Nada, Mahmoud A Al Aswad, Wael M El-Haig
PURPOSE: To evaluate the efficacy of combination therapy of a single intrastromal injection of amphotericin B and topical fluconazole in resistant cases of fungal keratitis, and also topical amphotericin B as monotherapy in terms of the duration of the recovery period and toxic drug effects. METHODS: This retrospective 2-year study reviewed 68 cases of unilateral fungal keratitis diagnosed by clinical features and positive laboratory culture results. Forty-one cases were resistant and did not respond to monotherapy with an antifungal agent...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28502889/three-dimensional-printing-facilitates-successful-endovascular-closure-of-a-type-ii-abernethy-malformation-using-an-amplatzer-atrial-septal-occluder-device
#16
Jeffrey Forris Beecham Chick, Shilpa N Reddy, Alice C Yu, Tatiana Kelil, Ravi N Srinivasa, Kyle J Cooper, Wael E Saad
Type II Abernethy malformations, characterized by side-to-side portosystemic shunting with preserved intrahepatic portal venous system, have been treated with shunt closure surgically and endovascularly. Three-dimensional printing has been used to develop highly accurate patient-specific representations for surgical and endovascular planning and intervention. This innovation describes three-dimensional printing to successfully close a flush-oriented type II Abernethy malformation, with discrepant dimensions on computed tomography, conventional venography, and intravascular ultrasound, using a 12-mm AMPLATZER atrial septal occluder device...
May 11, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28502071/update-from-the-abdominal-compartment-society-wsacs-on-intra-abdominal-hypertension-and-abdominal-compartment-syndrome-past-present-and-future-beyond-banff-2017
#17
Andrew W Kirkpatrick, Michael Sugrue, Jessica L McKee, Bruno M Pereira, Derek J Roberts, Jan J De Waele, Ari Leppaniemi, Janeth C Ejike, Annika Reintam Blaser, Scott D'Amours, Bart De Keulenaer, Manu L N G Malbrain
No abstract text is available yet for this article.
May 14, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28501743/antarctic-fish-versus-human-cytoglobins-the-same-but-yet-so-different
#18
Bert Cuypers, Stijn Vermeylen, Dietmar Hammerschmid, Stanislav Trashin, Vanoushe Rahemi, Albert Konijnenberg, Amy De Schutter, C-H Christina Cheng, Daniela Giordano, Cinzia Verde, Karolien De Wael, Frank Sobott, Sylvia Dewilde, Sabine Van Doorslaer
The cytoglobins of the Antarctic fish Chaenocephalus aceratus and Dissostichus mawsoni have many features in common with human cytoglobin. These cytoglobins are heme proteins in which the ferric and ferrous forms have a characteristic hexacoordination of the heme iron, i.e. axial ligation of two endogenous histidine residues, as confirmed by electron paramagnetic resonance, resonance Raman and optical absorption spectroscopy. The combined spectroscopic analysis revealed only small variations in the heme-pocket structure, in line with the small variations observed for the redox potential...
April 28, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28499366/the-role-of-brca1-iris-in-the-development-and-progression-of-triple-negative-breast-cancers-in-egypt-possible-link-to-disease-early-lesion
#19
Danielle Bogan, Lucio Meile, Ahmed El Bastawisy, Hend F Yousef, Abdel-Rahman N Zekri, Abeer A Bahnassy, Wael M ElShamy
BACKGROUND: Breast cancer is the most globally diagnosed female cancer, with the triple negative breast cancer (TNBC) being the most aggressive subtype of the disease. In this study we aimed at comparing the effect of BRCA1-IRIS overexpression on the clinico-pathological characteristics in breast cancer patients with TNBC or non-TNBC in the largest comprehensive cancer center in Egypt. METHODS: To reach this goal, we conducted an observational study at the National Cancer Institute (NCI), Cairo University (Cairo, Egypt)...
May 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28498796/interactions-between-cannabis-and-schizophrenia-in-humans-and-rodents
#20
Ahmed A Moustafa, Mohamed Salama, Roseanne Peak, Richard Tindle, Amir Salem, Szabolcs Keri, Błażej Misiak, Dorota Frydecka, Wael Mohamed
In this review, we provide an overview of the relationship between cannabis use and the development of schizophrenia, using both animal and human studies. We further discuss the potential neural mechanism that may mediate the relationship between cannabis use and schizophrenia symptoms. We finally provide clinical implications and future studies that can further elucidate the relationship between cannabis and schizophrenia.
May 12, 2017: Reviews in the Neurosciences
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