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https://www.readbyqxmd.com/read/28317626/one-year-survival-is-not-affected-by-gastrointestinal-bleeding-after-percutaneous-coronary-interventions
#1
Kyari Sumayin Ngamdu, Wael El Mallah, Alok Dwivedi, Rabab Mohsin, Sherif Elhanafi, Yi Jia, Luis A Alvarado, Debabrata Mukherjee, Marc J Zuckerman
BACKGROUND: Percutaneous coronary intervention (PCI) has been the main therapy in acute coronary syndromes, and early antithrombotic agents as well as 1-year dual antiplatelet therapy are required for adjuvant therapy. However, the development of post-PCI gastrointestinal (GI) bleeding may increase all-cause mortality. We compared the characteristics and outcomes of patients with GI bleeding within 1 year after PCI to those who did not develop bleeding. METHODS: A retrospective cohort study was conducted using data from 384 PCI procedures performed between January 2011 and December 2013 at our hospital...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28315942/forgotten-right-ventricle-in-pediatric-dilated-cardiomyopathy
#2
Hala Mounir Agha, Hossam Ibrahim, Inas Abd El Satar, Naglae Abd El Rahman, Doaa Abd El Aziz, Zeinab Salah, Sonia El Saeidi, Fatma Mostafa, Wael Attia, Mohamed Abd El Rahman, Gaser Abd El Mohsen
To evaluate the right ventricular (RV) function in relation to that of the left ventricle (LV) in patients with dilated cardiomyopathy (DCM). Echocardiographic examination was done using tissue Doppler imaging (TDI) and two-dimensional speckle tracking echocardiography (2D-STE) for 32 pediatric patients with DCM comparing them to another 32 normal matched controls. The global longitudinal strain (GLS) derived from 2D-STE was used to reflect the LV systolic function. Tricuspid annular plan systolic excursion (TAPSE) and the following RV TDI derived indexes: peak systolic velocity (S'), peak early diastolic velocity E', peak late diastolic velocity A', isovolumic acceleration (IVA) and myocardial performance index (MPI) were measured...
March 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28314474/sulforaphane-as-an-adjunctive-to-everolimus-counteracts-everolimus-resistance-in-renal-cancer-cell-lines
#3
Eva Juengel, Stephanie Euler, Sebastian Maxeiner, Jochen Rutz, Saira Justin, Frederik Roos, Wael Khoder, Karen Nelson, Wolf O Bechstein, Roman A Blaheta
BACKGROUND: The mechanistic target of rapamycin (mTOR) inhibitors, everolimus and temsirolimus, have widened therapeutic options to treat renal cell carcinoma (RCC). However, chronic treatment with these inhibitors often induces resistance, leading to therapeutic failure. PURPOSE: The natural compound, sulforaphane (SFN), was added to an everolimus based regime in vitro in the hopes of preventing resistance development. METHODS: A panel of RCC cell lines (A498, Caki-1, KTCTL-26) was treated with everolimus or SFN or with an everolimus-SFN-combination, either short- (24h) or long-term (8 weeks), and cell growth, proliferation, apoptosis, and cell cycle phases were measured...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28300232/the-phase-and-interfacial-properties-of-azeotropic-refrigerants-the-prediction-of-aneotropes-from-molecular-theory
#4
Wael A Fouad, Lourdes F Vega
The use of hydrofluorocarbons (HFCs) as alternative non-ozone depleting refrigerants for chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) has grown during the last couple of decades. Owing to their considerable global warming potential, a global deal has been reached recently to limit the production and consumption of HFCs. For rational design of new refrigerants that are environmentally friendlier, the thermodynamics of current ones need to be well understood first. In this work, we examine the phase behavior of azeotropic refrigerants obtained by mixing HFCs with normal alkanes...
March 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28293966/anatomic-reconstruction-of-the-anterior-cruciate-ligament-of-the-knee-with-or-without-reconstruction-of-the-anterolateral-ligament
#5
Samir Abdulrazik Ibrahim, Emad Mureed Shohdy, Yousef Marwan, Sami Abdulghaffar Ramadan, Abdulrahman Khalid Almisfer, Mohammad Wagdy Mohammad, Wael Shoabe Abdulsattar, Shiref Khirat
BACKGROUND: Rotational instability of the knee remains an issue after anterior cruciate ligament (ACL) reconstruction. Hypothesis/Purpose: The purpose was to evaluate the subjective and objective outcomes of combined reconstruction of the ACL and anterolateral ligament (ALL) of the knee. The hypothesis was that favorable outcomes can be achieved with this surgical procedure compared with isolated anatomic reconstruction of the ACL. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28292688/hybrid-statistics-simulations-based-method-for-atom-counting-from-adf-stem-images
#6
Annelies De Wael, Annick De Backer, Lewys Jones, Peter D Nellist, Sandra Van Aert
A hybrid statistics-simulations based method for atom-counting from annular dark field scanning transmission electron microscopy (ADF STEM) images of monotype crystalline nanostructures is presented. Different atom-counting methods already exist for model-like systems. However, the increasing relevance of radiation damage in the study of nanostructures demands a method that allows atom-counting from low dose images with a low signal-to-noise ratio. Therefore, the hybrid method directly includes prior knowledge from image simulations into the existing statistics-based method for atom-counting, and accounts in this manner for possible discrepancies between actual and simulated experimental conditions...
January 25, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28291719/immunization-with-outer-membrane-proteins-oprf-and-opri-and-flagellin-b%C3%A2-protects-mice-from-pulmonary-infection-with-mucoid-and-nonmucoid-pseudomonas-aeruginosa
#7
Ramadan Hassan, Wael El-Naggar, Abeer M Abd El-Aziz, Mona Shaaban, Hany I Kenawy, Youssif M Ali
BACKGROUND: Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium, which considered as a common cause of nosocomial infection and life-threatening complications in immunocompromized and cystic fibrosis patients. Here, we evaluate the protective effect of recombinant vaccines composed of outer membrane proteins OprF and OprI alone or in combination with flagellin B against mucoid and nonmucoid pseudomonas infection. METHODS: BALB/C mice were immunized subcutaneous using OprF and OprI with or without flagellin B and antibody titers were determined...
February 20, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28291623/bmi-is-inversely-correlated-to-the-risk-of-mortality-in-patients-with-type-2-diabetes-hospitalized-for-acute-heart-failure-findings-from-the-gulf-acute-heart-failure-gulf-care-registry
#8
Charbel Abi Khalil, Kadhim Sulaiman, Rajvir Singh, Amin Jayyousi, Nidal Asaad, Khalid F AlHabib, Alawi Alsheikh-Ali, Mohammed Al-Jarallah, Bassam Bulbanat, Wael AlMahmeed, Soha Dargham, Mustafa Ridha, Nooshin Bazargani, Haitham Amin, Ahmed Al-Motarreb, Husam AlFaleh, Abdelfatah Elasfar, Prashanth Panduranga, Jassim Al Suwaidi
BACKGROUND: A U-shaped relationship has been reported between BMI and cardiovascular events among patients with acute heart failure (AHF). We hypothesized that an obesity paradox also governs the relationship between BMI and mortality in patients with type 2 diabetes (T2D) and AHF. METHODS: We studied 3-month and 12-month mortality in patients with T2D hospitalized for AHF according to 5 BMI categories: Underweight (<20kg/m(2)), normal weight (referent group, 20-24...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28288952/outcomes-after-umbilical-cord-blood-transplantation-for-myelodysplastic-syndromes
#9
Aaron T Gerds, Kwang Woo Ahn, Zhen-Huan Hu, Hisham Abdel-Azim, Gorgun Akpek, Mahmoud Aljurf, Karen K Ballen, Amer Beitinjaneh, Ulrike Bacher, Jean-Yves Cahn, Saurabh Chhabra, Corey Cutler, Andrew Daly, Zachariah DeFilipp, Robert Peter Gale, Usama Gergis, Michael R Grunwald, Gregory A Hale, Betty Ky Hamilton, Madan Jagasia, Rammurti T Kamble, Tamila Kindwall-Keller, Taiga Nishihori, Richard F Olsson, Muthalagu Ramanathan, Ayman A Saad, Melhem Solh, Celalettin Ustun, David Valcárcel, Erica Warlick, Baldeep M Wirk, Matt Kalaycio, Edwin Alyea, Uday Popat, Ronald Sobecks, Wael Saber
For patients with hematologic malignancies undergoing allogeneic hematopoietic cell transplantation, umbilical cord blood transplantation (UCBT) has become an acceptable alternative donor source in the absence of a matched sibling or unrelated donor. However, there have been few published series dedicated solely to describing the outcomes of adult patients with myelodysplastic syndrome (MDS) who have undergone UCBT. From 2004 to 2013, 176 adult MDS patients underwent UCBT as reported to the Center for International Blood and Marrow Transplant Research...
March 10, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28288886/the-atmospheric-pressure-and-temperature-seem-to-have-no-effect-on-the-incidance-of-rupture-of-abdmonial-aortic-aneurysm-in-a-mid-european-region
#10
Payman Majd, Wael Ahmad, Thomas Luebke, Jan Sigge Brunkwall
BACKGROUND/OBJECTIVE: This study aims to examine the relationship between weather changes (atmospheric pressure and temprature) and incidence of rupture of abdominal aortic aneurysm. METHODS: All patients with ruptured infrarenal abdominal aortic aneurysm (AAA) and who were referred to our institution between August 1998 and August 2015 were prospectively entered into a database out of which a retrospective review of a ruptured AAA was performed. The needed information about the daily atmospheric pressure and air temperature could be extracted from the meteorological unit in Cologne...
March 10, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28286191/increased-intestinal-permeability-in-relatives-of-patients-with-crohn-s-disease-is-not-associated-with-small-bowel-ulcerations
#11
Christopher W Teshima, Karen J Goodman, Mohamed El-Kalla, Samina Turk, Wael El-Matary, Rosica Valcheva, Ronda Danchak, Marilyn Gordon, Peter Ho, Amanda Mullins, Daniel Wong, Dina Kao, Jonathan Meddings, Hien Huynh, Levinus A Dieleman
BACKGROUND & AIMS: Many first-degree relatives of patients with Crohn's disease (CD) have increased intestinal permeability. Video capsule endoscopy (VCE) is the most sensitive imaging test to identify small bowel mucosal lesions that indicate subclinical CD. We aimed to estimate the association of increased intestinal permeability with small bowel ulcerations detectable by VCE in healthy first-degree relatives of patients with CD. METHODS: We conducted a cross-sectional study of 223 healthy, asymptomatic first-degree relatives of patients with CD (parents, siblings, and children; 9-45 years old) enrolled at the University of Alberta between 2009 and 2012...
March 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28283933/designing-of-a-recombinant-agip-bacmid-construct-with-infectious-properties-against-black-cutworm-agrotis-ipsilon-larvae
#12
Naglaa A Abdallah, Wael El-Menofy, Abdelhadi Abdallah Abdelhadi
In this study, Agrotis ipsilon nucleopolyhedrovirus bacmid has been constructed as an infectious bacmid in an attempt to allow genome recombination and generation of virus mutants. Since the FseI, a unique restriction site, is located in a viral coding region (ORF_119), PCR was performed to partially amplify the ORF_119 fragment containing the FseI site to facilitate the bacmid construction in a proper way without interrupting the ORF expression. Construction with repeated fragments at the end of the cloned viral was carried out in an attempt to facilitate circulation during infection in insect cells...
March 10, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28282769/epigenetic-modifications-of-human-placenta-associated-with-preterm-birth-a-systematic-review
#13
Drissa M Toure, Wael ElRayes, Debora Barnes-Josiah, Teresa Hartman, David Klinkebiel, Lorena Baccaglini
OBJECTIVE: Preterm birth (PTB) is one of the leading causes of neonatal mortality and morbidity around the world. Epigenetic alterations of the human placenta may be involved in the causal chain of adverse pregnancy outcomes specifically PTB. In this systematic review, we investigated whether epigenetic dysregulation of the human placenta is associated with PTB. METHODS: We searched MEDLINE and EMBASE and systematically reviewed all relevant studies on epigenetic placental modifications in PTB...
February 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28281307/integrated-expression-analysis-identifies-transcription-networks-in-mouse-and-human-gastric-neoplasia
#14
Zheng Chen, Mohammed Soutto, Bushra Rahman, Muhammad W Fazili, DunFa Peng, Maria Blanca Piazuelo, Heidi Chen, M Kay Washington, Yu Shyr, Wael El-Rifai
Gastric cancer is a leading cause of cancer-related deaths worldwide. The Tff1 knockout (KO) mouse model develops gastric lesions that include low-grade dysplasia (LGD), high-grade dysplasia (HGD), and adenocarcinomas. In this study, we used Affymetrix microarrays gene expression platforms for analysis of molecular signatures in the mouse stomach (Tff1-KO (LGD) and Tff1 wild-type (normal)) and human gastric cancer tissues and their adjacent normal tissue samples. Combined integrated bioinformatics analysis of mouse and human datasets indicated that 172 genes were consistently deregulated in both human gastric cancer samples and Tff1-KO LGD lesions (P<0...
March 9, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28275524/high-single-scrotal-incision-orchidopexy-as-the-standard-technique-in-infants-aged-6-24%C3%A2-months
#15
Ahmed Mohey, Tarek M Gharib, Rabea G Omar, Ahmed Sebaey, Basheer N Elmohamady, Wael Kandeel
OBJECTIVE: To prospectively investigate the effectiveness of high single scrotal-incision orchidopexy (HSSIO) for palpable undescended testis (PUDT) in infants aged 6-24 months. PATIENTS AND METHODS: From March 2012 to July 2014, 46 age range-restricted (6-24 months) infants with 57 PUDT underwent HSSIO after obtaining written consent from their parents. The exclusion criteria were ectopic, retractile testes and recurrent cases. All infants were examined before surgery in the outpatient department and after anaesthesia induction immediately before surgery...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28275511/can-percutaneous-nephrolithotomy-be-performed-as-an-outpatient-procedure
#16
Ahmed Fahmy, Hazem Rhashad, Omer Algebaly, Wael Sameh
OBJECTIVES: To examine the safety and effectiveness of percutaneous nephrolithotomy (PCNL) as an outpatient procedure, as in most centres PCNL is performed as an inpatient procedure that necessitates postoperative hospital admission. PATIENTS AND METHODS: Our study included 186 patients undergoing PCNL for renal calculi. Only those who met strict inclusion criteria were discharged home on the same day. Preoperative eligibility criteria for outpatient management included no complex medical problem, normal renal function, and easy access to an emergency room...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28274689/combined-wharton-s-jelly-derived-mesenchymal-stem-cells-and-nerve-guidance-conduit-a-potential-promising-therapy-for-peripheral-nerve-injuries
#17
Sally M Shalaby, Amal S El-Shal, Faiza E Ahmed, Sahar F Shaban, Rania A Wahdan, Wael A Kandel, Mohammed S Senger
BACKGROUND: Peripheral nerve injuries represent a clinical problem with insufficient or unsatisfactory treatment options. Functional outcome with nerve guidance conduits was unsatisfactory in nerve defects with increased gap size. So, cell therapy may benefit as a tool for optimizing the regeneration process. The aim of the present study was to evaluate the impact of combination of cell therapy and nerve guidance conduits on the nerve regeneration and on the expression of the factors aiding the regeneration in a rat model of sciatic nerve injury...
March 5, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28271050/incidental-finding-of-adrenal-oncocytoma-after-right-robotic-adrenalectomy-case-report-and-literature-review
#18
Othman Alamoudi, Wael Alsulaiman, Naif Aldhaam, Maher Moazin
Oncocytic neoplasms occur in several organs and are most commonly found in the thyroid, kidneys and salivary glands. Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually non-functioning, benign and incidentally detected. However, histologically, they are characterized by cells with eosinophilic granular cytoplasm and numerous packed mitochondria. We report a case of 33 year old lady medically free complain of right flank pain radiated to the lower abdomen, not associated with any aggravating or relieving factor or any other symptom there was no evidence of hypertension symptom, by the Magnetic resonance imaging (MRI) showed that she has large heterogeneous mass seen at the right adrenal gland, and it was managed successfully by Robot-Assisted Right Adrenalectomy...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28270847/on-biometric-systems-electrocardiogram-gaussianity-and-data-synthesis
#19
Wael Louis, Shahad Abdulnour, Sahar Javaher Haghighi, Dimitrios Hatzinakos
Electrocardiogram is a slow signal to acquire, and it is prone to noise. It can be inconvenient to collect large number of ECG heartbeats in order to train a reliable biometric system; hence, this issue might result in a small sample size phenomenon which occurs when the number of samples is much smaller than the number of observations to model. In this paper, we study ECG heartbeat Gaussianity and we generate synthesized data to increase the number of observations. Data synthesis, in this paper, is based on our hypothesis, which we support, that ECG heartbeats exhibit a multivariate normal distribution; therefore, one can generate ECG heartbeats from such distribution...
December 2017: EURASIP Journal on Bioinformatics & Systems Biology
https://www.readbyqxmd.com/read/28267829/success-and-survival-of-various-types-of-all-ceramic-single-crowns-a-critical-review-and-analysis-of-studies-with-a-mean-follow-up-of-5-years-or-longer
#20
Alhanoof Aldegheishem, George Ioannidis, Wael Att, Haralampos Petridis
PURPOSE: The aim of this critical review was to assess the survival and success rates of all-ceramic single crowns manufactured using different ceramic materials with a mean follow-up time of 5 years or longer. MATERIALS AND METHODS: An electronic search of studies published between 1980 and 2014 complemented by manual searching was conducted in Medline and Scopus. The terms ceramic, crown, survival, success, longevity, and complications were selected as keywords...
March 2017: International Journal of Prosthodontics
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