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https://www.readbyqxmd.com/read/29778225/identification-growth-and-toxicity-assessment-of-coolia-meunier-dinophyceae-from-nova-scotia-canada
#1
Nancy I Lewis, Jennifer L Wolny, John Claude Achenbach, Lee Ellis, Joseph S Pitula, Cheryl Rafuse, Detbra S Rosales, Pearse McCarron
Benthic dinoflagellates of the toxigenic genus Coolia Meunier (Dinophyceae) are known to have a global distribution in both tropical and temperate waters. The type species, C. monotis, has been reported from the Mediterranean Sea, the NE Atlantic and from Rhode Island, USA in the NW Atlantic, whereas other species in the genus have been reported from tropical locations. Coolia cells were observed in algal drift samples collected at seven sites in Nova Scotia, Canada. Clonal isolates were established from four of these locations and identified with light and scanning electron microscopy, then confirmed with genetic sequencing to be C...
May 2018: Harmful Algae
https://www.readbyqxmd.com/read/29778211/serological-survey-for-antibodies-against-pestiviruses-in-wyoming-domestic-sheep
#2
S Silveira, S M Falkenberg, M J Elderbrook, K S Sondgeroth, R P Dassanayake, J D Neill, J F Ridpath, C W Canal
Pestiviruses including Bovine viral diarrhea virus type 1 (BVDV-1), BVDV-2 and Border disease virus (BDV) have been reported in both sheep and cattle populations, together with the HoBi-like, an emerging group of pestiviruses. Pestivirus control programs in the United States have focused on the control of BVDV-1 and 2. The incidence of pestivirus infection in sheep in the United States and the risk of transmission between cattle and sheep populations are unknown. The aim of this study was to perform serological surveillance for pestivirus exposure in sheep from an important sheep producing state in the Unites States, Wyoming...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29778206/occurrence-and-characterisation-of-esbl-encoding-plasmids-among-escherichia-coli-isolates-from-fresh-vegetables
#3
Christin Freitag, G B Michael, Jun Li, Kristina Kadlec, Yang Wang, Melanie Hassel, Stefan Schwarz
Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates have been increasingly reported in different reservoirs. The aims of this study were to investigate the presence of ESBL-producing E. coli in fresh vegetables and to characterise their ESBL gene-carrying plasmids. Among the 245 samples from vegetables investigated during 2011-2013, seven putative ESBL-producing E. coli (salad n = 2, sprouts n = 5) were found. They were subjected to ESBL phenotypic confirmatory tests, detection/sequencing of ESBL genes, antimicrobial susceptibility testing (AST), phylotyping, XbaI-macrorestriction analysis, multilocus sequence typing and transformation...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29777269/pediatric-appendicitis-severity-in-kwazulu-natal-south-africa-a-retrospective-cohort-analysis
#4
Matthew C Hernandez, Victor Y Kong, John L Bruce, Johnathon M Aho, Grant L Laing, Martin D Zielinski, Damian L Clarke
BACKGROUND: Acute appendicitis is a common pediatric surgical emergency; however, there are few grading systems to assign disease severity. The American Association for the Surgery of Trauma (AAST) recently developed a grading system for a variety of emergency surgical conditions, including appendicitis. The severity of acute appendicitis in younger patients in KwaZulu-Natal (South Africa) is unknown. We aimed to describe the disease severity in this patient population using the AAST grading system hypothesizing that the AAST grade would correlate with morbidity, management type, and duration of stay...
May 17, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29776921/determining-the-pneumococcal-conjugate-vaccine-coverage-required-for-indirect-protection-against-vaccine-type-pneumococcal-carriage-in-low-and-middle-income-countries-a-protocol-for-a-prospective-observational-study
#5
Jocelyn Chan, Cattram D Nguyen, Jana Y R Lai, Eileen M Dunne, Ross Andrews, Christopher C Blyth, Siddhartha Datta, Kim Fox, Rebecca Ford, Jason Hinds, Sophie La Vincente, Deborah Lehmann, Ruth Lim, Tuya Mungun, Paul N Newton, Rattanaphone Phetsouvanh, Willam S Pomat, Anonh Xeuatvongsa, Claire von Mollendorf, David A B Dance, Catherine Satzke, Kim Muholland, Fiona M Russell
INTRODUCTION: Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children using hospital-based NP pneumococcal carriage surveillance at three sites in Asia and the Pacific...
May 18, 2018: BMJ Open
https://www.readbyqxmd.com/read/29776471/good-functional-outcomes-expected-after-shoulder-arthroplasty-irrespective-of-body-mass-index
#6
David D Savin, Rachel M Frank, Shelby Sumner, Catherine Richardson, Gregory P Nicholson, Anthony A Romeo
BACKGROUND: This study evaluated how body mass index (BMI) factors into functional outcomes and complications after shoulder arthroplasty. METHODS: A retrospective analysis was performed of age-matched patients with a minimum 2-year follow-up after total shoulder arthroplasty (TSA), reverse total shoulder arthroplasty (RTSA), or hemiarthroplasty (HA). Patient-reported outcome (PRO) scores, range of motion (ROM), and complications were assessed. Forty-nine patients were classified into the following groups: normal (BMI <24...
June 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29775153/feasibility-safety-and-changes-in-systolic-blood-pressure-associated-with-endovascular-revascularization-of-symptomatic-and-chronically-occluded-cervical-internal-carotid-artery-using-a-newly-suggested-radiographic-classification-of-chronically-occluded-cervical
#7
David Hasan, Mario Zanaty, Robert M Starke, Elias Atallah, Nohra Chalouhi, Pascal Jabbour, Amit Singla, Waldo R Guerrero, Daichi Nakagawa, Edgar A Samaniego, Nnenna Mbabuike, Rabih G Tawk, Adnan H Siddiqui, Elad I Levy, Roberta L Novakovic, Jonathan White, Clemens M Schirmer, Thomas G Brott, Hussain Shallwani, L Nelson Hopkins
OBJECTIVE The overall risk of ischemic stroke from a chronically occluded internal carotid artery (COICA) is around 5%-7% per year despite receiving the best available medical therapy. Here, authors propose a radiographic classification of COICA that can be used as a guide to determine the technical success and safety of endovascular recanalization for symptomatic COICA and to assess the changes in systemic blood pressure following successful revascularization. METHODS The radiographic images of 100 consecutive subjects with COICA were analyzed...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29775079/improved-glycemic-control-with-minimal-change-in-medication-regimen-complexity-in-a-pharmacist-endocrinologist-diabetes-intense-medical-management-dimm-tune-up-clinic
#8
Candis M Morello, Taylor Rotunno, John Khoan, Jan D Hirsch
BACKGROUND: Gaining glycemic control in patients with type 2 diabetes (T2D) usually requires more complicated medication regimens. Increased medication regimen complexity (MRC) negatively impacts adherence and clinical outcomes. OBJECTIVE: Compare MRC change in patients with uncontrolled T2D referred to a collaborative pharmacist-endocrinologist Diabetes Intense Medical Management (DIMM) clinic "tune up" model versus similar patients receiving usual primary care provider (PCP) care over 6 months...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29774571/clustering-and-variable-selection-in-the-presence-of-mixed-variable-types-and-missing-data
#9
C B Storlie, S M Myers, S K Katusic, A L Weaver, R G Voigt, P E Croarkin, R E Stoeckel, J D Port
We consider the problem of model-based clustering in the presence of many correlated, mixed continuous, and discrete variables, some of which may have missing values. Discrete variables are treated with a latent continuous variable approach, and the Dirichlet process is used to construct a mixture model with an unknown number of components. Variable selection is also performed to identify the variables that are most influential for determining cluster membership. The work is motivated by the need to cluster patients thought to potentially have autism spectrum disorder on the basis of many cognitive and/or behavioral test scores...
May 17, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29774348/a-new-series-of-co-ni-zn-and-cd-metal-organic-architectures-driven-by-an-unsymmetrical-biphenyl-tricarboxylic-acid-hydrothermal-assembly-structural-features-and-properties
#10
Jin-Zhong Gu, Yan Cai, Zi-Yue Qian, Min Wen, Zi-Fa Shi, Dong-Yu Lv, Alexander M Kirillov
This study reports the hydrothermal synthesis of a novel series of twelve coordination compounds, namely, {[Cd(μ-Hnbtc)(H2O)4]·H2O}n (1), [Zn2(μ-Hnbtc)2(phen)2]·2H2O (2), [Zn(Hnbtc)(phen)2(H2O)]·4.5H2O (3), [Ni(Hnbtc)(phen)2(H2O)]·6H2O (4), [Zn2(μ-Hnbtc)2(2,2'-bipy)2]·2H2O (5), [Cd3(μ5-nbtc)(μ6-nbtc)(2,2'-bipy)2(H2O)]n (6), {[Zn3(μ3-nbtc)2(phen)3(H2O)2]·4H2O} (7), [Co(H2O)6][Co2(nbtc)2(μ-4,4'-bipy)(4,4'-bipy)2(H2O)6]·8H2O (8), {[Ni3(μ4-nbtc)2(μ-4,4'-bipy)2.5(μ-H2O)(H2O)3]·4H2O}n (9), {[Cd2(μ4-nbtc)(μ-OH)(2,2'-bipy)2]·H2O}n (10), [Cd2(μ4-nbtc)(μ-OH)(phen)2(H2O)]n (11), and {[Zn2(μ5-nbtc)(μ3-OH)(μ-4,4'-bipy)]·4,4'-bipy·H2O}n (12), which are derived from 3'-nitro-biphenyl-2,4,4'-tricarboxylic acid (H3nbtc) as a virtually unexplored building block...
May 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29774126/autophagy-deficient-breast-cancer-shows-early-tumor-recurrence-and-escape-from-dormancy
#11
Hussein F Aqbi, Liliya Tyutyunyk-Massey, Rebecca C Keim, Savannah E Butler, Theresa Thekkudan, Supriya Joshi, Timothy M Smith, Dipankar Bandyopadhyay, Michael O Idowu, Harry D Bear, Kyle K Payne, David A Gewirtz, Masoud H Manjili
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse earlier than others. In addition, some tumor clones respond to immunotherapy while others do not. We investigated how autophagy plays a role in accelerating or delaying recurrence of neu-overexpressing mouse mammary carcinoma (MMC) following adriamycin (ADR) treatment, and in affecting response to immunotherapy...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773932/effectiveness-and-tolerability-of-therapy-with-once-weekly-exenatide-versus-basal-insulin-among-injectable-naive-patients-with-type-2-diabetes-in-a-real-world-setting-in-the-united-states
#12
Anita M Loughlin, Qing Qiao, Anthony P Nunes, Stephen M Ezzy, Laura Yochum, C Robin Clifford, Robert V Gately, David D Dore, John D Seeger
A propensity-matched cohort study compared injectable-naive patients with type 2 diabetes initiating exenatide once weekly (EQW) or basal insulin (BI), from 2012 through 2015, within a U.S. electronic health record database. A1C and weight were obtained as observed or multiply imputed values at baseline and quarterly for 1 year (Q1-Q4). Hypoglycemia and gastrointestinal symptoms were identified using diagnostic codes and clinical notes. EQW ( n = 2,008) and BI ( n = 4,016) cohorts were comparable at baseline (mean A1C and weight: EQW, 8...
May 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29773687/the-role-of-intercalated-cell-nedd4-2-in-bp-regulation-ion-transport-and-transporter-expression
#13
Masayoshi Nanami, Truyen D Pham, Young Hee Kim, Baoli Yang, Roy L Sutliff, Olivier Staub, Janet D Klein, Karen I Lopez-Cayuqueo, Regine Chambrey, Annie Y Park, Xiaonan Wang, Vladimir Pech, Jill W Verlander, Susan M Wall
Background Nedd4-2 is an E3 ubiquitin-protein ligase that associates with transport proteins, causing their ubiquitylation, and then internalization and degradation. Previous research has suggested a correlation between Nedd4-2 and BP. In this study, we explored the effect of intercalated cell (IC) Nedd4-2 gene ablation on IC transporter abundance and function and on BP. Methods We generated IC Nedd4-2 knockout mice using Cre-lox technology and produced global pendrin/ Nedd4-2 null mice by breeding global Nedd4-2 null ( Nedd4-2-/- ) mice with global pendrin null ( Slc26a4-/- ) mice...
May 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29773462/derotation-of-the-mallet-piece-a-crucial-point-in-mallet-fracture-surgery
#14
B Karslıoğlu, M Uzun, C Tetik, E Tasatan, A C Tekin, C D Buyukkurt
Mallet fracture is an avulsion of the extensor tendon and fracture of the dorsal rim of the articular surface of distal phalanx at the same time. If a part of the mallet fracture is angled or rotated to such a degree that prevents full anatomic reduction, malunion and deformities may occur as a result. The objective of this study was to describe a new surgical technique to provide derotation of the mallet fracture. A 22G or 21G needle is used like a joystick to reduce the mallet fracture with small, gentle movements...
May 14, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29773346/predicting-inferior-vena-cava-ivc-filter-retrievability-using-positional-parameters-a-comparative-study-of-various-filter-types
#15
A Gotra, C Doucet, P Delli Fraine, A Bessissow, C Dey, B Gallix, L-M Boucher, D Valenti
PURPOSE: To compare changes in inferior vena cava (IVC) filter positional parameters from insertion to removal and examine how they affect retrievability amongst various filter types. MATERIALS AND METHODS: A total of 447 patients (260 men, 187 women) with a mean age of 55 years (range: 13-91 years) who underwent IVC filter retrieval between 2007-2014 were retrospectively included. Post-insertion and pre-retrieval angiographic studies were assessed for filter tilt, migration, strut wall penetration and retrieval outcomes...
May 14, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29772844/leucine-supplementation-does-not-attenuate-skeletal-muscle-loss-during-leg-immobilization-in-healthy-young-men
#16
Evelien M P Backx, Astrid M H Horstman, Gabriel N Marzuca-Nassr, Janneau van Kranenburg, Joey S Smeets, Cas J Fuchs, Anniek A W Janssen, Lisette C P G M de Groot, Tim Snijders, Lex B Verdijk, Luc J C van Loon
BACKGROUND: Short successive periods of physical inactivity occur throughout life and contribute considerably to the age-related loss of skeletal muscle mass. The maintenance of muscle mass during brief periods of disuse is required to prevent functional decline and maintain metabolic health. OBJECTIVE: To assess whether daily leucine supplementation during a short period of disuse can attenuate subsequent muscle loss in vivo in humans. METHODS: Thirty healthy (22 ± 1 y) young males were exposed to a 7-day unilateral knee immobilization intervention by means of a full leg cast with (LEU, n = 15) or without (CON, n = 15) daily leucine supplementation (2...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29772373/a-novel-c-type-lectin-from-the-sea-cucumber-apostichopus-japonicus-ajctl-2-with-preferential-binding-of-d-galactose
#17
Hui Wang, Zhuang Xue, Zhaoqun Liu, Weilin Wang, Feifei Wang, Ying Wang, Lingling Wang, Linsheng Song
C-type lectins (CTLs) are Ca2+ dependent carbohydrate-binding proteins that share structural homology in their carbohydrate-recognition domains (CRDs). In the present study, a novel CTL was identified from sea cucumber Apostichopus japonicus (named as AjCTL-2). The deduced amino acid sequence of AjCTL-2 was homologous to CTLs from other animals with the identities ranging from 33% to 40%. It contained a canonical signal peptide at the N-terminus, a low density lipoprotein receptor class A (LDLa), a C1r/C1s/Uegf/bone morphogenetic protein 1 (CUB), and a CRD with two motif Glu-Pro-Asn (EPN) and Trp-Asn-Asp (WND) in Ca2+ binding site 2...
May 14, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29771824/psychological-and-behavioral-responses-to-interval-and-continuous-exercise
#18
Matthew J Stork, Martin J Gibala, Kathleen A Martin Ginis
PURPOSE: To compare psychological responses to, and preferences for, moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), and sprint interval training (SIT) among inactive adults; and to investigate the relationships between affect, enjoyment, exercise preferences, and subsequent exercise behavior over a 4-wk follow-up period. METHODS: Thirty inactive men and women (21.23±3.81 y), inexperienced with HIIT or SIT, completed three trials of cycle ergometer exercise in random order on separate days: MICT (45min continuous; ~70-75% of heart rate maximum (HRmax)); HIIT (10x1 min bouts at ~85-90%HRmax with 1-min recovery periods); and SIT (3x20-s "all-out" sprints with 2-min recovery periods)...
May 16, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29771456/serum-serotonin-levels-in-patients-with-epileptic-seizures
#19
Arun Murugesan, M R Sandhya Rani, Johnson Hampson, Bilal Zonjy, Nuria Lacuey, Carl L Faingold, Daniel Friedman, Orrin Devinsky, Rup K Sainju, Stephan Schuele, Beate Diehl, Maromi Nei, Ronald M Harper, Lisa M Bateman, George Richerson, Samden D Lhatoo
Profound cardiovascular and/or respiratory dysfunction is part of the terminal cascade in sudden unexpected death in epilepsy (SUDEP). Central control of ventilation is mediated by brainstem rhythm generators, which are influenced by a variety of inputs, many of which use the modulatory neurotransmitter serotonin to mediate important inputs for breathing. The aim of this study was to investigate epileptic seizure-induced changes in serum serotonin levels and whether there are potential implications for SUDEP...
May 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29770887/the-importance-of-early-recognition-in-management-of-ercp-related-perforations
#20
Jason G Bill, Zachary Smith, Joseph Brancheck, Jeffrey Elsner, Paul Hobbs, Gabriel D Lang, Dayna S Early, Koushik Das, Thomas Hollander, Maria B Majella Doyle, Ryan C Fields, William G Hawkins, Steven M Strasberg, Chet Hammill, William C Chapman, Steven Edmundowicz, Daniel K Mullady, Vladimir M Kushnir
BACKGROUND: Iatrogenic perforations related to endoscopic retrograde cholangiopancreatography (ERCP) are rare events, carrying with it a mortality of up to 8%. Given the rarity of this adverse event, there remains limited data and continued uncertainties when choosing therapeutic strategies. Our aims were to evaluate the management of ERCP-related perforations and compare outcomes based on timing of recognition. METHODS: The endoscopic databases of two tertiary care centers were interrogated to identify consecutive adult patients who sustained ERCP-related perforation over a 10-year period from 2006 to 2016...
May 16, 2018: Surgical Endoscopy
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