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https://www.readbyqxmd.com/read/29161273/enrichment-of-colorectal-cancer-associations-in-functional-regions-insight-for-using-epigenomics-data-in-the-analysis-of-whole-genome-sequence-imputed-gwas-data
#1
Stephanie A Bien, Paul L Auer, Tabitha A Harrison, Conghui Qu, Charles M Connolly, Peyton G Greenside, Sai Chen, Sonja I Berndt, Stéphane Bézieau, Hyun M Kang, Jeroen Huyghe, Hermann Brenner, Graham Casey, Andrew T Chan, John L Hopper, Barbara L Banbury, Jenny Chang-Claude, Stephen J Chanock, Robert W Haile, Michael Hoffmeister, Christian Fuchsberger, Mark A Jenkins, Suzanne M Leal, Mathieu Lemire, Polly A Newcomb, Steven Gallinger, John D Potter, Robert E Schoen, Martha L Slattery, Joshua D Smith, Loic Le Marchand, Emily White, Brent W Zanke, Goncalo R Abeçasis, Christopher S Carlson, Ulrike Peters, Deborah A Nickerson, Anshul Kundaje, Li Hsu
BACKGROUND: The evaluation of less frequent genetic variants and their effect on complex disease pose new challenges for genomic research. To investigate whether epigenetic data can be used to inform aggregate rare-variant association methods (RVAM), we assessed whether variants more significantly associated with colorectal cancer (CRC) were preferentially located in non-coding regulatory regions, and whether enrichment was specific to colorectal tissues. METHODS: Active regulatory elements (ARE) were mapped using data from 127 tissues and cell-types from NIH Roadmap Epigenomics and Encyclopedia of DNA Elements (ENCODE) projects...
2017: PloS One
https://www.readbyqxmd.com/read/29160610/do-pregnancy-characteristics-contribute-to-rising-childhood-cancer-incidence-rates-in-the-united-states
#2
Rebecca D Kehm, Theresa L Osypuk, Jenny N Poynter, David M Vock, Logan G Spector
BACKGROUND: Since 1975, childhood cancer incidence rates have gradually increased in the United States; however, few studies have conducted analyses across time to unpack this temporal rise. The aim of this study was to test the hypothesis that increasing cancer incidence rates are due to secular trends in pregnancy characteristics that are established risk factors for childhood cancer incidence including older maternal age, higher birthweight, and lower birth order. We also considered temporal trends in sociodemographic characteristics including race/ethnicity and poverty...
November 21, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29160338/changes-in-energy-and-motor-activity-core-symptoms-of-bipolar-mania-and-depression
#3
Elie Cheniaux, Rafael de A da Silva, Cristina M Santana, Alberto Filgueiras
OBJECTIVE: To evaluate how well symptom rating scales differentiate bipolar disorder (BD) episode types. METHODS: One hundred and six patients with BD were followed for 13 years. At each visit, the following clinical scales were administered: Young Mania Rating Scale (YMRS), Hamilton Depression Scale (HAM-D) and Clinical Global Impressions scale for use in bipolar illness (CGI-BP). To perform a comparison between the affective states of BP, three time points in each patient's follow-up period were chosen for evaluation: the most severe manic episode, the most severe depressive episode, and the euthymic period with least symptoms...
November 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29160108/effects-of-hepato-preferential-basal-insulin-peglispro-on-nuclear-magnetic-resonance-biomarkers-lipoprotein-insulin-resistance-index-and-glyca-in-patients-with-diabetes
#4
Margery A Connelly, James D Otvos, Qianyi Zhang, Shuyu Zhang, Caryl J Antalis, Annette M Chang, Byron J Hoogwerf
AIM: To characterize the effects of hepato-preferential basal insulin peglispro (BIL) and insulin glargine on insulin resistance (lipoprotein insulin resistance index [LP-IR]) and inflammation (GlycA), and to explore the biological implications. METHODS: This substudy included 847 patients with Type 1 diabetes (T1D) or Type 2 diabetes (T2D) in four cohorts of the BIL development program. LP-IR and GlycA were measured before and after insulin treatment. Correlations between LP-IR, GlycA, clinical parameters and liver biomarkers were assessed...
November 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29159937/diffusion-weighted-mri-and-intravoxel-incoherent-motion-model-for-diagnosis-of-pediatric-solid-abdominal-tumors
#5
Emma M Meeus, Niloufar Zarinabad, Karen A Manias, Jan Novak, Heather E L Rose, Hamid Dehghani, Katharine Foster, Bruce Morland, Andrew C Peet
BACKGROUND: Pediatric retroperitoneal tumors in the renal bed are often large and heterogeneous, and their diagnosis based on conventional imaging alone is not possible. More advanced imaging methods, such as diffusion-weighted (DW) MRI and the use of intravoxel incoherent motion (IVIM), have the potential to provide additional biomarkers that could facilitate their noninvasive diagnosis. PURPOSE: To assess the use of an IVIM model for diagnosis of childhood malignant abdominal tumors and discrimination of benign from malignant lesions...
November 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29159877/crystalline-structure-of-pulverized-dental-calculus-induces-cell-death-in-oral-epithelial-cells
#6
S M Ziauddin, A Yoshimura, J L Montenegro Raudales, Y Ozaki, K Higuchi, T Ukai, T Kaneko, T Miyazaki, E Latz, Y Hara
BACKGROUND AND OBJECTIVE: Dental calculus is a mineralized deposit attached to the tooth surface. We have shown that cellular uptake of dental calculus triggers nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation, leading to the processing of the interleukin-1β precursor into its mature form in mouse and human phagocytes. The activation of the NLRP3 inflammasome also induced a lytic form of programmed cell death, pyroptosis, in these cells...
November 20, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29159267/long-term-impact-of-intensive-lifestyle-intervention-on-cognitive-function-assessed-with-the-national-institutes-of-health-toolbox-the-look-ahead-study
#7
Kathleen M Hayden, Laura D Baker, George Bray, Raymond Carvajal, Kathryn Demos-McDermott, Andrea L Hergenroeder, James O Hill, Edward Horton, John M Jakicic, Karen C Johnson, Rebecca H Neiberg, Stephen R Rapp, Thomas A Wadden, Michael E Miller
Introduction: This study sought to determine whether 10 years of assignment to intensive lifestyle intervention (ILI) relative to diabetes support and education leads to better cognition. We examine intervention effects overall and among clinical subgroups, and report correlations between computer-administered and interviewer-administered cognitive batteries. Methods: The Action for Health in Diabetes (Look AHEAD) was a 16-site randomized controlled trial with overweight/obese individuals (aged 45-76) who had type 2 diabetes...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29158905/genome-sequence-and-description-of-mobilicoccus-massiliensis-sp-nov-isolated-from-the-stool-of-a-nigerian-boy-with-kwashiorkor
#8
N Mathlouthi, S I Traore, T Cimmino, S Khelaifia, T T Nguyen, F Cadoret, C Couderc, D Raoult, J-M Rolain
Mobilicoccus massiliensis strain SIT2 (= CSUR P1306 = DSM 29065) is a new type strain of Mobilicoccus sp. nov. isolated from the stool of a 2-year-old Nigerian boy with kwashiorkor. M. massiliensis is Gram positive, facultatively anaerobic, nonsporulating and motile. The 3 842 438 bp long genome contains 3362 protein-coding and 49 RNA genes, including one 5S rRNA gene, one 16S rRNA gene, one 23S rRNA gene and 46 tRNA genes.
November 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/29158583/patient-derived-ipscs-show-premature-neural-differentiation-and-neuron-type-specific-phenotypes-relevant-to-neurodevelopment
#9
E Yeh, D Q Dao, Z Y Wu, S M Kandalam, F M Camacho, C Tom, W Zhang, R Krencik, K A Rauen, E M Ullian, L A Weiss
Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior. We studied the role of the mutation BRAF(Q257R), the most common cause of cardiofaciocutaneous syndrome (CFC), in an induced pluripotent stem cell (iPSC)-derived model of human neurodevelopment. In iPSC-derived neuronal cultures from CFC subjects, we observed decreased p-AKT and p-ERK1/2 compared to controls, as well as a depleted neural progenitor pool and rapid neuronal maturation...
November 21, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29158011/extended-adjuvant-intermittent-letrozole-versus-continuous-letrozole-in-postmenopausal-women-with-breast-cancer-sole-a-multicentre-open-label-randomised-phase-3-trial
#10
Marco Colleoni, Weixiu Luo, Per Karlsson, Jacquie Chirgwin, Stefan Aebi, Guy Jerusalem, Patrick Neven, Erika Hitre, Marie-Pascale Graas, Edda Simoncini, Claus Kamby, Alastair Thompson, Sibylle Loibl, Joaquín Gavilá, Katsumasa Kuroi, Christian Marth, Bettina Müller, Seamus O'Reilly, Vincenzo Di Lauro, Andrea Gombos, Thomas Ruhstaller, Harold Burstein, Karin Ribi, Jürg Bernhard, Giuseppe Viale, Rudolf Maibach, Manuela Rabaglio-Poretti, Richard D Gelber, Alan S Coates, Angelo Di Leo, Meredith M Regan, Aron Goldhirsch
BACKGROUND: In animal models of breast cancer, resistance to continuous use of letrozole can be reversed by withdrawal and reintroduction of letrozole. We therefore hypothesised that extended intermittent use of adjuvant letrozole would improve breast cancer outcome compared with continuous use of letrozole in postmenopausal women. METHODS: We did the multicentre, open-label, randomised, parallel, phase 3 SOLE trial in 240 centres (academic, primary, secondary, and tertiary care centres) in 22 countries...
November 17, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29157323/prevalence-and-factors-associated-with-multidrug-resistant-gram-negative-organisms-in-patients-with-spinal-cord-injury
#11
Charlesnika T Evans, Margaret A Fitzpatrick, Makoto M Jones, Stephen P Burns, Linda Poggensee, Swetha Ramanathan, Sherri L LaVela, Nasia Safdar, Katie J Suda
OBJECTIVE Infections caused by multidrug-resistant gram-negative organisms (MDRGNOs) have been increasing every year. The objective of this study was to describe the prevalence of MDRGNOs and factors associated with MDRGNOs in patients with spinal cord injury or disorder (SCI/D). DESIGN Retrospective cohort study. METHODS Department of Veterans Affairs (VA) electronic health record data from 142 VA facilities were evaluated for 19,642 patients with SCI/D. Multivariable cluster-adjusted models were fit to identify factors associated with MDRGNO...
November 21, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29155051/peripheral-monocyte-entry-is-required-for-alpha-synuclein-induced-inflammation-and-neurodegeneration-in-a-model-of-parkinson-disease
#12
Ashley S Harms, Aaron D Thome, Zhaoqi Yan, Aubrey M Schonhoff, Gregory P Williams, Xinru Li, Yudong Liu, Hongwei Qin, Etty N Benveniste, David G Standaert
Accumulation of alpha-synuclein (α-syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate immune system, production of inflammatory cytokines and chemokines, and subsequent neurodegeneration. Here, we used heterozygous reporter knock-in mice in which the first exons of the fractalkine receptor (CX3CR1) and of the C-C chemokine receptor type 2 (CCR2) are replaced with fluorescent reporters to study the role of resident microglia (CX3CR1+) and infiltrating peripheral monocytes (CCR2+), respectively, in the CNS...
November 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29154685/a-qualitative-analysis-of-real-time-continuous-glucose-monitoring-data-sharing-with-care-partners-to-share-or-not-to-share
#13
Michelle L Litchman, Nancy A Allen, Vanessa D Colicchio, Sarah E Wawrzynski, Kerri M Sparling, Krissa L Hendricks, Cynthia A Berg
BACKGROUND: Little research exists regarding how real-time continuous glucose monitoring (RT-CGM) data sharing plays a role in the relationship between patients and their care partners. OBJECTIVE: To (1) identify the benefits and challenges related to RT-CGM data sharing from the patient and care partner perspective and (2) to explore the number and type of individuals who share and follow RT-CGM data. METHODS: This qualitative content analysis was conducted by examining publicly available blogs focused on RT-CGM and data sharing...
November 20, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29153746/degree-of-conversion-of-resin-cement-with-varying-methacrylate-compositions-used-to-cement-fiber-dowels-a-raman-spectroscopy-study
#14
Abdulelah M BinMahfooz, Osama A Qutub, Thamer Y Marghalani, Mohammed F Ayad, Abdulhamaid A Maghrabi
STATEMENT OF PROBLEM: Studies on the degree of conversion of dental cement in relation to the number of methacrylate components are lacking. PURPOSE: The purpose of this in vitro study was to evaluate the degree of conversion of single- and multicomponent methacrylate-containing dental cements around opaque and translucent fiber dowels at varying depths. MATERIAL AND METHODS: Teeth were prepared for standard endodontic therapy, and a dowel space was created...
November 15, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29153593/the-molecular-phenotypes-of-ureteral-telocytes-are-layer-specific
#15
M A Dobra, A D Vrapciu, F Pop, N Petre, M C Rusu
Telocytes (TC) are the delicate interstitial (stromal) cells defined by their long, thin and moniliform processes termed telopodes. Numerous studies determined that different subsets of telocytes populate almost all tissues and attempted to relate these subsets to various functions, from cell signaling to tissue repair and regeneration. Extremely few studies addressed the urinary tract though few data on the molecular pattern of the urinary TCs actually exist. We therefore hypothesized that subsets of urinary TCs co-localize within the human ureter and we aimed at performing an immunohistochemical study to evaluate the tissue-specific molecular pattern of TCs...
November 16, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29151597/association-of-plasma-phospholipid-polyunsaturated-and-trans-fatty-acids-with-body-mass-index-results-from-the-multi-ethnic-study-of-atherosclerosis
#16
T A Hastert, M C de Oliveira Otto, F Lê-Scherban, B T Steffen, L M Steffen, M Y Tsai, D R Jacobs, A Baylin
BACKGROUND/OBJECTIVE: Previous research has focused on associations between dietary fat and body mass index (BMI), but the contributions of different types of fat to BMI remain unclear. The purpose of this study is to estimate whether plasma phospholipid omega-3 (n-3), omega-6 (n-6), or trans fatty acids are associated with BMI at baseline and with subsequent BMI changes over time; and whether total phospholipid n-6 or trans fatty acids modify any association between phospholipid n-3 and BMI...
November 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29151596/comparison-of-regional-fat-measurements-by-dual-energy-x-ray-absorptiometry-and-conventional-anthropometry-and-their-association-with-markers-of-diabetes-and-cardiovascular-disease-risk
#17
S K Vasan, C Osmond, D Canoy, C Christodoulides, M J Neville, C Di Gravio, C H D Fall, F Karpe
BACKGROUND/OBJECTIVE: Fat distribution is a strong and independent predictor of type 2 diabetes (T2D) and cardiovascular disease (CVD) and is usually determined using conventional anthropometry in epidemiological studies. Dual-energy X-ray absorptiometry (DXA) can measure total and regional adiposity more accurately. Nonetheless, whether DXA provides more precise estimates of cardiovascular risk in relation to total and regional adiposity is not known. We determined the strength of the associations between DXA- and conventional anthropometry determined fat distribution and T2D and CVD risk...
November 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29151159/enhanced-catalytic-efficiency-and-enantioselectivity-of-epoxide-hydrolase-from-agrobacterium-radiobacter-ad1-by-iterative-saturation-mutagenesis-for-r-epichlorohydrin-synthesis
#18
Shu-Ping Zou, Yu-Guo Zheng, Qun Wu, Zhi-Cai Wang, Ya-Ping Xue, Zhi-Qiang Liu
Enantioselective hydrolysis of epoxides by epoxide hydrolase (EH) is one of the most attractive approaches for the synthesis of chiral epoxides. So far, attempts to develop an efficient epoxide hydrolase -mediated biotransformation have been limited by either the low activity or insufficient enantioselectivity of epoxide hydrolase. In this study, iterative saturation mutagenesis (ISM) of epoxide hydrolase from Agrobacterium radiobacter AD1 (ArEH) was performed for efficient production of (R)-epichlorohydrin...
November 18, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29151143/salinity-reduces-2-4-d-efficacy-in-echinochloa-crusgalli-by-affecting-redox-balance-nutrient-acquisition-and-hormonal-regulation
#19
Faisal Islam, Yuan Xie, Muhammad A Farooq, Jian Wang, Chong Yang, Rafaqat A Gill, Jinwen Zhu, Weijun Zhou
Distinct salinity levels have been reported to enhance plants tolerance to different types of stresses. The aim of this research is to assess the interaction of saline stress and the use of 2,4-D as a means of controlling the growth of Echinochloa crusgalli. The resultant effect of such interaction is vital for a sustainable approach of weed management and food production. The results showed that 2,4-D alone treatment reduces the chlorophyll contents, photosynthetic capacity, enhanced MDA, electrolyte leakage, and ROS production (H2O2, O2(·-)) and inhibited the activities of ROS scavenging enzymes...
November 18, 2017: Protoplasma
https://www.readbyqxmd.com/read/29150696/impact-of-prolonged-overfeeding-on-skeletal-muscle-mitochondria-in-healthy-individuals
#20
Frederico G S Toledo, Darcy L Johannsen, Jeffrey D Covington, Sudip Bajpeyi, Bret Goodpaster, Kevin E Conley, Eric Ravussin
AIMS/HYPOTHESES: Reduced mitochondrial capacity in skeletal muscle has been observed in obesity and type 2 diabetes. In humans, the aetiology of this abnormality is not well understood but the possibility that it is secondary to the stress of nutrient overload has been suggested. To test this hypothesis, we examined whether sustained overfeeding decreases skeletal muscle mitochondrial content or impairs function. METHODS: Twenty-six healthy volunteers (21 men, 5 women, age 25...
November 17, 2017: Diabetologia
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