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nanomaterial and biofilm

Xiang Xiao, Wen-Wen Zhu, Qiu-Yue Liu, Hang Yuan, Wen-Wei Li, Li-Jun Wu, Qian Li, Han-Qing Yu
The release of nanomaterials into the environment, due to their massive production and application today, has caused ecological and health safety concerns. Semiconductor photocatalysts like TiO2 exhibit cytotoxicity to bacterial cells when exposed to UV irradiation. However, information about their impacts on individual or group bacterial behaviors is limited. In this work, the biofilm formation of Escherichia coli K12 in the presence of TiO2 with and without UV irradiation was investigated and biofilm formation was found not to be affected under the sole application of TiO2 or UV irradiation...
October 13, 2016: Environmental Science & Technology
Brahma N Singh, Prateeksha, Dalip K Upreti, Braj Raj Singh, Tom Defoirdt, Vijai K Gupta, Ana Olivia De Souza, Harikesh Bahadur Singh, João C M Barreira, Isabel C F R Ferreira, Khabat Vahabi
Despite several conventional potent antibacterial therapies, bacterial infections pose a significant threat to human health because they are emerging as the leading cause of death worldwide. Due to the development of antibiotic resistance in bacteria, there is a pressing demand to discover novel approaches for developing more effective therapies to treat multidrug-resistant bacterial strains and biofilm-associated infections. Therefore, attention has been especially devoted to a new and emerging branch of science "nanotechnology" to design non-conventional antimicrobial chemotherapies...
August 10, 2016: Critical Reviews in Biotechnology
Li-Sheng Wang, Akash Gupta, Vincent M Rotello
Treatment of biofilm-associated infections is challenging, requiring the development of new therapeutic strategies. In this viewpoint, we discuss the use of nanoparticle-based systems as active therapeutic agents and as vehicles to transport drugs to the site of infection. These applications require understanding of the surface interactions of nanoparticles with bacteria/biofilms, an aspect that we likewise summarize.
January 8, 2016: ACS Infectious Diseases
D Inbakandan, C Kumar, M Bavanilatha, Dune Naga Ravindra, R Kirubagaran, S Ajmal Khan
The knowhow followed for synthesis, characterization and application of nanomaterials has become an important branch of nanoscience. The use of marine sponges for the synthesis of metal nanoparticles is still in the budding level of current nanobiotechnology. This paper reports a single step one pot biosynthesis utilizing marine sponge (Haliclona exigua) extract as a reducing agent by means of a conventional ultrasonic bath on the formation and growth of flower like silver nanocolloids. These silver nanocolloids were characterized through UV visible spectroscopy, High Resolution Transmission Electron Microscope, Fourier Transform Infrared spectroscopy and X-ray Diffractometer...
October 2016: Microbial Pathogenesis
Achyut Konwar, Sanjeeb Kalita, Jibon Kotoky, Devasish Chowdhury
We report a robust biofilm with antimicrobial properties fabricated from chitosan-iron oxide coated graphene oxide nanocomposite hydrogel. For the first time, the coprecipitation method was used for the successful synthesis of iron oxide coated graphene oxide (GIO) nanomaterial. After this, films were fabricated by the gel-casting technique aided by the self-healing ability of the chitosan hydrogel network system. Both the nanomaterial and the nanocomposite films were characterized by techniques such as scanning electron microscopy, FT-IR spectroscopy, X-ray diffraction, and vibrating sample magnetometry...
August 17, 2016: ACS Applied Materials & Interfaces
Qilin Yu, Jianrong Li, Yueqi Zhang, Yufan Wang, Lu Liu, Mingchun Li
Owing to the growing infectious diseases caused by eukaryotic and prokaryotic pathogens, it is urgent to develop novel antimicrobial agents against clinical pathogenic infections. Biofilm formation and invasion into the host cells are vital processes during pathogenic colonization and infection. In this study, we tested the inhibitory effect of Au nanoparticles (AuNPs) on pathogenic growth, biofilm formation and invasion. Interestingly, although the synthesized AuNPs had no significant toxicity to the tested pathogens, Candida albicans and Pseudomonas aeruginosa, the nanoparticles strongly inhibited pathogenic biofilm formation and invasion to dental pulp stem cells (DPSCs)...
2016: Scientific Reports
Sabine Szunerits, Alexandre Barras, Rabah Boukherroub
Bacterial infectious diseases, sharing clinical characteristics such as chronic inflammation and tissue damage, pose a major threat to human health. The steady increase of multidrug-resistant bacteria infections adds up to the current problems modern healthcare is facing. The treatment of bacterial infections with multi-resistant germs is very difficult, as the development of new antimicrobial drugs is hardly catching up with the development of antibiotic resistant pathogens. These and other considerations have generated an increased interest in the development of viable alternatives to antibiotics...
April 2016: International Journal of Environmental Research and Public Health
Akash Gupta, Ryan F Landis, Vincent M Rotello
Bacterial infections cause 300 million cases of severe illness each year worldwide. Rapidly accelerating drug resistance further exacerbates this threat to human health. While dispersed (planktonic) bacteria represent a therapeutic challenge, bacterial biofilms present major hurdles for both diagnosis and treatment. Nanoparticles have emerged recently as tools for fighting drug-resistant planktonic bacteria and biofilms. In this review, we present the use of nanoparticles as active antimicrobial agents and drug delivery vehicles for antibacterial therapeutics...
2016: F1000Research
Ignacio Rivero Berti, María Laura Dell' Arciprete, María Laura Dittler, Alejandro Miñan, Mónica Fernández Lorenzo de Mele, Mónica Gonzalez
The delivery capacity and mechanical stability of calcium phosphate (CaP) coated 1,2-dioleoyl-sn-glycero-3-phosphate (DOPA) liposomes free and adsorbed on bacterial surface was investigated introducing either acridine orange (AO) or 5,10,15,20-Tetrakis(1-methyl-4-pyridinio)porphyrin (TMP) in the aqueous core of the liposomes. The obtained nanomaterials were thoroughly characterized by electron and optical microscopy and by fluorescence techniques. Distribution of the AO and TMP molecules between the aqueous liposomes core and the outer solution was demonstrated by the band shifts and broadening of the excitation-emission matrices and the modified Stern-Volmer model for fluorescence quenching...
June 1, 2016: Colloids and Surfaces. B, Biointerfaces
J R Lawrence, M J Waiser, G D W Swerhone, J Roy, V Tumber, A Paule, A P Hitchcock, J J Dynes, D R Korber
Commercial production of nanoparticles (NP) has created a need for research to support regulation of nanotechnology. In the current study, microbial biofilm communities were developed in rotating annular reactors during continuous exposure to 500 μg L(-1) of each nanomaterial and subjected to multimetric analyses. Scanning transmission X-ray spectromicroscopy (STXM) was used to detect and estimate the presence of the carbon nanomaterials in the biofilm communities. Microscopy observations indicated that the communities were visibly different in appearance with changes in abundance of filamentous cyanobacteria in particular...
May 2016: Environmental Science and Pollution Research International
G Sharma, S Sharma, P Sharma, D Chandola, S Dang, S Gupta, R Gabrani
Escherichia coli biofilm consists of a bacterial colony embedded in a matrix of extracellular polymeric substances (EPS) which protects the microbes from adverse environmental conditions and results in infection. Besides being the major causative agent for recurrent urinary tract infections, E. coli biofilm is also responsible for indwelling medical device-related infectivity. The cell-to-cell communication within the biofilm occurs due to quorum sensors that can modulate the key biochemical players enabling the bacteria to proliferate and intensify the resultant infections...
August 2016: Journal of Applied Microbiology
Kshipra Naik, Pallavee Srivastava, Ketaki Deshmukh, M S Monsoor, Meenal Kowshik
Biofilm formation is a major problem in medical device-related infections leading to failure of implant-based therapies. Though various conventional approaches to counter biofilm formation like physical and/or mechanical removal, chemical removal, and the use of antimicrobials exist, they fail due to increased resistance of biofilms. This review discusses various nanomaterial-based approaches such as the use of metallic and metal oxide nanoparticles- and polymer-based nanocomposites, which are currently being developed for prevention and treatment of biofilms...
December 2015: Journal of Nanoscience and Nanotechnology
Carolina Parra, Fernando Dorta, Edra Jimenez, Ricardo Henríquez, Cristian Ramírez, Rodrigo Rojas, Patricio Villalobos
BACKGROUND: Biofouling, the colonization of artificial and natural surfaces by unwanted microorganisms, has an important economic impact on a wide range of industries. Low cost antifouling strategies are typically based on biocides which exhibit a negative environmental impact, affecting surrounding organisms related and not related to biofouling. Considering that the critical processes resulting in biofouling occur in the nanoscale/microscale dimensions, in this work we present a bionanotechnological approach to reduce adhesion of biofilm-producing bacteria Halomonas spp...
2015: Journal of Nanobiotechnology
Denise T de Castro, Mariana L C Valente, José Augusto M Agnelli, Cláudia H Lovato da Silva, Evandro Watanabe, Renato L Siqueira, Oswaldo L Alves, Raphael D Holtz, Andréa C dos Reis
STATEMENT OF PROBLEM: The accumulation of bacteria on the surface of dental prostheses can lead to systemic disease. PURPOSE: The purpose of this in vitro study was to evaluate the growth of Staphylococcus aureus and Pseudomonas aeruginosa on the surface of autopolymerizing (AP) and heat-polymerizing (HP) acrylic resins incorporated with nanostructured silver vanadate (β-AgVO3) and its impact strength. MATERIAL AND METHODS: For each resin, 216 circular specimens (9 × 2 mm) were prepared for microbiologic analysis and 60 rectangular specimens (65 × 10 × 3...
February 2016: Journal of Prosthetic Dentistry
Tsui-Yin Wong, Hsin-Hsin Peng, Cheng-Yeu Wu, Jan Martel, David M Ojcius, Fu-Yung Hsu, John D Young
AIMS: Mineralo-organic nanoparticles (NPs) detected in biological fluids have been described as precursors of physiological and pathological calcifications in the body. Our main objective was to examine the early stages of mineral NP formation in body fluids. MATERIALS & METHODS: A nanomaterial approach based on atomic force microscopy, dynamic light scattering, electron microscopy and spectroscopy was used. RESULTS: The mineral particles, which contain the serum proteins albumin and fetuin-A, initially precipitate in the form of round amorphous NPs that gradually grow in size, aggregate and coalesce to form crystalline mineral films similar to the structures observed in calcified human arteries...
2015: Nanomedicine
Rui Yin, Tanupriya Agrawal, Usman Khan, Gaurav K Gupta, Vikrant Rai, Ying-Ying Huang, Michael R Hamblin
The relentless advance of drug-resistance among pathogenic microbes, mandates a search for alternative approaches that will not cause resistance. Photodynamic inactivation (PDI) involves the combination of nontoxic dyes with harmless visible light to produce reactive oxygen species that can selectively kill microbial cells. PDI can be broad-spectrum in nature and can also destroy microbial cells in biofilms. Many different kinds of nanoparticles have been studied to potentiate antimicrobial PDI by improving photosensitizer solubility, photochemistry, photophysics and targeting...
2015: Nanomedicine
Navid B Saleh, Bryant Chambers, Nirupam Aich, Jaime Plazas-Tuttle, Hanh N Phung-Ngoc, Mary Jo Kirisits
Metal and metal-oxide nanoparticles (NPs) are used in numerous applications and have high likelihood of entering engineered and natural environmental systems. Careful assessment of the interaction of these NPs with bacteria, particularly biofilm bacteria, is necessary. This perspective discusses mechanisms of NP interaction with bacteria and identifies challenges in understanding NP-biofilm interaction, considering fundamental material attributes and inherent complexities of biofilm structure. The current literature is reviewed, both for planktonic bacteria and biofilms; future challenges and complexities are identified, both in light of the literature and a dataset on the toxicity of silver NPs toward planktonic and biofilm bacteria...
2015: Frontiers in Microbiology
Priyanka Singh, Yeon J Kim, Chao Wang, Ramya Mathiyalagan, Deok C Yang
Nanoparticles and nanomaterials are at the prominent edge of the rapidly developing field of nanotechnology. Recently, nanoparticle synthesis using biological resources has been found to be a new area with considerable prospects for development. Biological systems are the masters of ambient condition chemistry and are able to synthesize nanoparticles by utilizing metal salts. In the perspective of the current initiative to develop green technologies for the synthesis of nanoparticles, microorganisms are of considerable interest...
September 2016: Artificial Cells, Nanomedicine, and Biotechnology
Spela Zupancic, Petra Kocbek, Sasa Baumgartner, Julijana Kristl
Periodontal disease is chronic inflammation of periodontal tissues resulting in formation of periodontal pockets, periodontal attachment loss and progressive destruction of the ligament and alveolar bone. This review gives an update on periodontal disease pathogenesis, which is important for the development of novel methods and delivery systems for its treatment. The available treatment approaches, including removal of dental plaque, modulation of the host inflammatory response, and regeneration of periodontal tissue, are reviewed and their drawbacks discussed...
2015: Current Pharmaceutical Design
Gianluigi Franci, Annarita Falanga, Stefania Galdiero, Luciana Palomba, Mahendra Rai, Giancarlo Morelli, Massimiliano Galdiero
Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. Advances in nanotechnology have opened new horizons in nanomedicine, allowing the synthesis of nanoparticles that can be assembled into complex architectures. Novel studies and technologies are devoted to understanding the mechanisms of disease for the design of new drugs, but unfortunately infectious diseases continue to be a major health burden worldwide...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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