Merrill J Egorin, Dhvani D Shah, Susan M Christner, Mara A Yerk, Kristin A Komazec, Leonard R Appleman, Robert L Redner, Brian M Miller, Jan H Beumer
AIMS: Imatinib mesylate (Gleevec/Glivec), which has revolutionized the treatment of chronic myeloid leukemias (CML) and gastrointestinal stromal tumours (GIST), has been reported to cause gastric upset. Consequently, proton pump inhibitors (PPI) are frequently co-administered with imatinib. Because PPI can elevate gastric pH and delay gastric emptying or antagonize ATP-binding-cassette transporters, they could influence imatinib absorption and pharmacokinetics. We aimed to evaluate whether use of omeprazole has a significant effect on imatinib pharmacokinetics...
September 2009: British Journal of Clinical Pharmacology