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Single nucleotide polymorphism and vitamins

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https://www.readbyqxmd.com/read/29320465/crp-genotypes-predict-increased-risk-to-co-present-with-low-vitamin-d-and-elevated-crp-in-a-group-of-healthy-black-south-african-women
#1
Pieter H Myburgh, G Wayne Towers, Iolanthé M Kruger, Cornelie Nienaber-Rousseau
Low 25-hydroxyvitamin D (25(OH)D) and elevated C-reactive protein (CRP) concentrations are independently associated with adverse health outcomes, including cardiovascular disease (CVD). Although an inverse association between these factors has been described, the underlying mechanisms remain unknown. We postulate that environment-gene interactions, through which 25(OH)D interacts with single nucleotide polymorphisms (SNPs) within the CRP gene, modulate CRP; that certain CRP genotypes predispose individuals to a co-phenotype of low 25(OH)D and elevated CRP concentrations; and that this co-phenotype is associated with higher CVD risk...
January 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29316495/vdr-and-gc-gene-polymorphisms-modulate-the-risk-of-lumbar-disc-degeneration-in-iran
#2
Sohail Mashayekhi, Alia Saberi, Zivar Salehi, Gelareh Biazar, Roghayeh Mehrdel
OBJECTIVE: Lumbar disc degeneration (LDD) occurs commonly in humans. Vitamin D metabolic and signaling pathway plays a significant role in intervertebral disc degeneration. The aim of this study was to evaluate the influence of the genetic polymorphism in the two key genes of 1,25-(OH)2-D3 pathway, VDR (vitamin D receptor) and GC (group-specific component), in LDD development. PATIENTS AND METHODS: Two single-nucleotide polymorphisms, VDR rs2228570 (FokI) and GC rs7041, were genotyped in 180 patients with LDD and 230 healthy individuals...
December 29, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29315215/association-between-vitamin-d-genetic-risk-score-and-cancer-risk-in-a-large-cohort-of-u-s-women
#3
Paulette D Chandler, Deirdre K Tobias, Lu Wang, Stephanie A Smith-Warner, Daniel I Chasman, Lynda Rose, Edward L Giovannucci, Julie E Buring, Paul M Ridker, Nancy R Cook, JoAnn E Manson, Howard D Sesso
Some observational studies suggest an inverse association between circulating 25-hydroxyvitamin D (25OHD) and cancer incidence and mortality. We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Analysis was performed in the Women's Genome Health Study (WGHS), including 23,294 women of European ancestry who were cancer-free at baseline and followed for 20 years for incident cancer...
January 9, 2018: Nutrients
https://www.readbyqxmd.com/read/29273767/the-rs2108622-polymorphism-is-related-to-the-early-risk-of-ischemic-stroke-in-non-valvular-atrial-fibrillation-subjects-under-oral-anticoagulation
#4
L Colàs-Campàs, J L Royo, M V Montserrat, C Marzo, J Molina-Seguín, I Benabdelhak, S Cambray, F Purroy
Oral anticoagulant treatments, such as vitamin K antagonists (VKAs), are the main treatments administered to atrial fibrillation (AF) patients in order to prevent ischemic stroke (IS). However, the genes involved in the VKA metabolism can undergo variations in a single nucleotide (SNP). These SNPs may then affect the VKA target enzyme (VKORC1), VKA degradation enzyme (CYP2C9), and vitamin K bioavailability enzyme (CYP4F2). We genotyped these SNPs in a cohort of patients with non-valvular AF who were under VKA treatment after suffering an IS...
December 22, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29259981/association-between-single-nucleotide-polymorphisms-in-vitamin-d-receptor-gene-polymorphisms-and-permanent-tooth-caries-susceptibility-to-permanent-tooth-caries-in-chinese-adolescent
#5
Miao Yu, Qian-Zhou Jiang, Zhe-Yi Sun, Yuan-Yuan Kong, Zhi Chen
Purpose: Dental caries is a multifactorial infectious disease. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene were associated with susceptibility to permanent tooth caries in Chinese adolescents. Method: A total of 200 dental caries patients and 200 healthy controls aged 12 years were genotyped for VDR gene polymorphisms using the PCR-restriction fragment length polymorphism (PCR-RFLP) assay. All of them were examined for their oral and dental status with the WHO criteria, and clinical information such as the Decayed Missing Filled Teeth Index (DMFT) was evaluated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29249824/associations-of-genetic-determinants-of-serum-vitamin-b12-and-folate-concentrations-with-hay-fever-and-asthma-a-mendelian-randomization-meta-analysis
#6
Tea Skaaby, Amy E Taylor, Rikke K Jacobsen, Line T Møllehave, Nele Friedrich, Betina H Thuesen, Daniel Mønsted Shabanzadeh, Lavinia Paternoster, Uwe Völker, Matthias Nauck, Henry Völzke, Marcus Munafò, Torben Hansen, Oluf Pedersen, Torben Jørgensen, Niels Grarup, Allan Linneberg
BACKGROUND/OBJECTIVES: Studies of the effect of vitamin B12 and folate on the risk of asthma and hay fever have shown inconsistent results that may be biased by reverse causation and confounding. We used a Mendelian randomization approach to examine a potential causal effect of vitamin B12 and folate on hay fever, asthma, and selected biomarkers of allergy by using 11 vitamin B12-associated single-nucleotide polymorphisms (SNPs) and 2 folate-associated SNPs as unconfounded markers. SUBJECTS/METHODS: We included 162,736 participants from 9 population-based studies including the UK Biobank...
December 18, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29239065/vitamin-d-receptor-rs2228570-polymorphism-and-susceptibility-to-ovarian-cancer-an-updated-meta-analysis
#7
Hongmei Chen, Jin Zhu
AIM: The FokI polymorphism (C>T, rs2228570) of the vitamin D receptor gene is a coding nonsynonymous single nucleotide polymorphism in the translational initiation codon reported to have functional significance. Although the role of rs2228570 in the risk of ovarian cancer has been widely researched, the association is still unclear. We performed an updated meta-analysis to clarify this issue. METHODS: Eligible studies were retrieved from electronic databases for the period 2007-2016...
December 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29220424/genetically-deprived-vitamin-d-exposure-predisposes-to-atrial-fibrillation
#8
Yap-Hang Chan, Kai-Hang Yiu, Jo Jo Hai, Pak-Hei Chan, Tai-Hing Lam, Ben J Cowling, Pak-Chung Sham, Chu-Pak Lau, Karen Siu-Ling Lam, Chung-Wah Siu, Hung-Fat Tse
Aims: Low vitamin D level is associated with atrial fibrillation (AF) and may be implicated in its pathogenesis. Methods and results: We studied single nucleotide polymorphisms (SNPs) of vitamin D mechanistic pathways and serum 25-hydroxyvitamin D [25(OH)D] levels in an age- and gender-matched case-control study (controls without AF: mean age 68.6 ± 8.7 years, female 25%; n = 1019; with AF: mean age 69.7 ± 9.5 years, female 30%; n = 156) recruited from a Chinese clinical cohort of patients with stable coronary artery disease...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29214886/clinical-and-molecular-aspects-of-lead-toxicity-an-update
#9
Prasenjit Mitra, Shailja Sharma, Purvi Purohit, Praveen Sharma
Lead toxicity is a major public health issue in developed and developing countries. Both acute and chronic lead exposure has the potential to cause many deleterious systematic effects including hypertension, frank anemia, cognitive deficits, infertility, immune imbalances, delayed skeletal and deciduous dental development, vitamin D deficiency, and gastrointestinal effects. The underlying mechanisms for all these systemic effects have not been elucidated completely. However, the most plausible cause is free radical damage...
November 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29202697/genetic-diversity-and-association-mapping-of-mineral-element-concentrations-in-spinach-leaves
#10
Jun Qin, Ainong Shi, Beiquan Mou, Michael A Grusak, Yuejin Weng, Waltram Ravelombola, Gehendra Bhattarai, Lingdi Dong, Wei Yang
BACKGROUND: Spinach is a useful source of dietary vitamins and mineral elements. Breeding new spinach cultivars with high nutritional value is one of the main goals in spinach breeding programs worldwide, and identification of single nucleotide polymorphism (SNP) markers for mineral element concentrations is necessary to support spinach molecular breeding. The purpose of this study was to conduct a genome-wide association study (GWAS) and to identify SNP markers associated with mineral elements in the USDA-GRIN spinach germplasm collection...
December 4, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29175129/vitamin-d-metabolic-loci-and-vitamin-d-status-in-black-and-white-pregnant-women
#11
Katharyn M Baca, Manika Govil, Joseph M Zmuda, Hyagriv N Simhan, Mary L Marazita, Lisa M Bodnar
BACKGROUND: Several candidate genes and genome wide association studies have reported significant associations between vitamin D metabolism genes and 25-hydroxyvitamin D. Few studies have examined these relationships in pregnancy. OBJECTIVE: We evaluated the relationship between maternal allelic variants in three vitamin D metabolism genes and 25-hydroxyvitamin D (25(OH)D) concentration in pregnancy. STUDY DESIGN: In two case-control studies, samples were drawn from women who delivered at Magee Womens Hospital in Pittsburgh, PA from 1999 to 2010 and twelve recruiting sites across the United States from 1959 to 65...
November 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29165650/evaluation-of-1-25-dihydroxyvitamin-d3-pathway-in-patients-with-chronic-urticaria
#12
Rasoul Nasiri-Kalmarzi, Mohammad Abdi, Javad Hosseini, Erfan Babaei, Aram Mokarizadeh, Zakaria Vahabzadeh
BACKGROUND: Previous studies showed the role of vitamin D (Vit D) on the progression of chronic urticaria. To the best of our knowledge, there are no other results regarding the contribution of single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes in Chronic Urticaria (CU). AIM: In the present study, we investigated the Vit pathway and the association between VDR and VDBP gene polymorphisms and CU risk in Iranian population...
November 20, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29164277/high-prevalence-of-dengue-antibodies-and-the-arginine-variant-of-the-fc%C3%AE-riia-polymorphism-in-asymptomatic-individuals-in-a-population-of-minas-gerais-state-southeast-brazil
#13
Anna Carolina Toledo da Cunha Pereira, Tatiane Ribeiro de Siqueira, Andressa Anunciação de Oliveira Prado, Camila Almeida Veiga da Silva, Thaís de Fátima Silva Moraes, Alan Alex Aleixo, José Carlos de Magalhaes, Gabriel Augusto Pires de Souza, Betânia Paiva Drumond, Gustavo Portela Ferreira, Breno de Mello Silva, Cintia Lopes de Brito Magalhães, Luciana Lara Santos, Jaqueline Maria Siqueira Ferreira, Luiz Cosme Cotta Malaquias, Luiz Felipe Leomil Coelho
Dengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil...
November 21, 2017: Immunogenetics
https://www.readbyqxmd.com/read/29160302/role-of-cyp24a1-vdr-and-gc-gene-polymorphisms-on-deferasirox-pharmacokinetics-and-clinical-outcomes
#14
S Allegra, J Cusato, S De Francia, A Arduino, F Longo, E Pirro, D Massano, A De Nicolò, A Piga, A D'Avolio
β-Thalassemia patients develop deficiency in vitamin D absorption and liver hydroxylation, resulting in extremely low calcitriol levels. We explored the role of single-nucleotide polymorphisms (SNPs) involved in vitamin D metabolism, transport and activity on deferasirox pharmacokinetics and outcomes (effectiveness trough levels (Ctrough) and the area under the curve (AUC) cutoffs of 20 μg ml(-1) and 360 μg ml(-1) h(-1), respectively; nonresponse AUC limit of 250 μg ml(-1) h(-1)). Ninety-nine β-thalassemic patients were enrolled...
November 21, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29128634/vitamin-d-receptor-vdr-polymorphisms-are-associated-to-spontaneous-preterm-birth-and-maternal-aspects
#15
N R Javorski, C A D Lima, L V C Silva, S Crovella, J de Azêvedo Silva
Preterm birth (PTB) is featured by less than 37weeks of gestational age or fewer than 259days since the first day from the last menstrual period. Complications of PTB are the major cause of neonatal deaths, several factors are linked to PTB increased risk including immunological and genetics. Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy. Herein we assessed two single nucleotide polymorphisms (SNPs) FokI (rs2228570 A>G) and Cdx-2 (rs11568820 T>C), within VDR, using TaqMan fluorogenic probes, and differential susceptibility to SPTB...
November 8, 2017: Gene
https://www.readbyqxmd.com/read/29128211/genome-wide-association-studies-to-identify-quantitative-trait-loci-affecting-milk-production-traits-in-water-buffalo
#16
J J Liu, A X Liang, G Campanile, G Plastow, C Zhang, Z Wang, A Salzano, B Gasparrini, M Cassandro, L G Yang
Water buffalo is the second largest resource of milk supply around the world, and it is well known for its distinctive milk quality in terms of fat, protein, lactose, vitamin, and mineral contents. Understanding the genetic architecture of milk production traits is important for future improvement by the buffalo breeding industry. The advance of genome-wide association studies (GWAS) provides an opportunity to identify potential genetic variants affecting important economical traits. In the present study, GWAS was performed for 489 buffaloes with 1,424 lactation records using the 90K Affymetrix Buffalo SNP Array (Affymetrix/Thermo Fisher Scientific, Santa Clara, CA)...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29128193/vitamin-d-levels-vitamin-d-receptor-polymorphisms-and-inflammatory-cytokines-in-aromatase-inhibitor-induced-arthralgias-an-analysis-of-cctg-ma-27
#17
Polly Niravath, Bingshu Chen, Judy-Anne W Chapman, Sandeep K Agarwal, Robert L Welschhans, Tim Bongartz, Krishna R Kalari, Lois E Shepherd, John Bartlett, Kathleen Pritchard, Karen Gelmon, Susan G Hilsenbeck, Mothaffar F Rimawi, C Kent Osborne, Paul E Goss, James N Ingle
BACKGROUND: Approximately half of women taking aromatase inhibitor (AI) therapy develop AI-induced arthralgia (AIA), and many might discontinue AI therapy because of the pain. Using plasma samples from the MA.27 study, we assessed several factors potentially associated with AIA. PATIENTS AND METHODS: MA.27 is a phase III adjuvant trial comparing 2 AIs, exemestane versus anastrozole. Within an 893-participant nested case-control AIA genome-wide association study, we nested a 72 AIA case-144 control assessment of vitamin D plasma concentrations, corrected for seasonal and geographic variation...
October 16, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29124814/validation-of-an-updated-associative-transcriptomics-platform-for-the-polyploid-crop-species-brassica-napus-by-dissection-of-the-genetic-architecture-of-erucic-acid-and-tocopherol-isoform-variation-in-seeds
#18
Lenka Havlickova, Zhesi He, Lihong Wang, Swen Langer, Andrea L Harper, Harjeevan Kaur, Martin R Broadley, Vasilis Gegas, Ian Bancroft
An updated platform was developed to underpin association genetics studies in the polyploid crop species Brassica napus (oilseed rape). Based on 1.92 × 1012 bases of leaf mRNAseq data, functional genotypes, comprising 355 536 single-nucleotide polymorphism markers and transcript abundance were scored across a genetic diversity panel of 383 accessions using a transcriptome reference comprising 116 098 ordered coding DNA sequence (CDS) gene models. The use of the platform for Associative Transcriptomics was first tested by analysing the genetic architecture of variation in seed erucic acid content, as high-erucic rapeseed oil is highly valued for a variety of applications in industry...
November 10, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29122496/determinants-of-low-bone-mineral-density-in-children-with-epilepsy
#19
Choong Yi Fong, Ann Nie Kong, Mazidah Noordin, Bee Koon Poh, Lai Choo Ong, Ching Ching Ng
INTRODUCTION: Children with epilepsy on long-term antiepileptic drugs (AEDs) are at risk of low bone mineral density (BMD). The aims of our study were to evaluate the prevalence and determinants of low BMD among Malaysian children with epilepsy. METHOD: Cross-sectional study of ambulant children with epilepsy on long-term AEDs for >1 year seen in a tertiary hospital in Malaysia from 2014 to 2015. Detailed assessment of anthropometric measurements; environmental lifestyle risk factors; serum vitamin D, calcium and parathyroid hormone levels; genotyping of single nucleotide polymorphisms of genes in vitamin D and calcium metabolism; and lumbar spine BMD were obtained...
October 24, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29108239/interactions-between-vitamin-d-receptor-vdr-gene-and-interleukin-6-gene-and-environment-factors-on-coronary-heart-disease-risk-in-a-chinese-han-population
#20
Ma Jun, Guan Xue-Qiang, Li Jia, Xue Yang-Jing, Zheng Cheng, Jin Ge
Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within Interleukin-6 (IL- 6) and vitamin D receptor (VDR) gene, and additional gene- gene and gene- smoking interaction with coronary heart disease (CHD) risk in a Chinese population. Methods: Hardy-Weinberg equilibrium (HWE) examination was used by SNPstats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking...
October 3, 2017: Oncotarget
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