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https://www.readbyqxmd.com/read/29212397/growth-and-neurodevelopment-in-very-preterm-infants-receiving-a-high-enteral-volume-feeding-regimen-a-population-based-cohort-study
#1
Claus Klingenberg, Fredrik Kragh Muraas, Catherine Elde Isaksen, Tina Nilsen, Marte Torgersen, Cecilie Melum-Hansen
AIM: To evaluate a feeding regimen routinely providing > 180 ml/kg/d fortified human milk to very preterm infants and impact on in-hospital growth, osteopenia and neurodevelopment. METHOD: Retrospective population-based descriptive study of infants < 30-week gestation admitted within 24 h of birth and discharged during the 6-year period 2005 to 2010. Growth and neurodevelopment was assessed until 2 years corrected age, and cerebral palsy up to 4 years corrected age Results: Ninety-nine infants below 30-week gestation were admitted within 24 h of birth during the 6-year period, of which 84 (85%) survived to discharge...
December 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29210601/ranking-quantitative-resistance-to-septoria-tritici-blotch-in-elite-wheat-cultivars-using-automated-image-analysis
#2
Petteri Karisto, Andreas Hund, Kang Yu, Jonas Anderegg, Achim Walter, Fabio Mascher, Bruce A McDonald, Alexey Mikaberidze
Quantitative resistance is likely to be more durable than major gene resistance for controlling Septoria tritici blotch (STB) on wheat. Earlier studies hypothesized that resistance affecting the degree of host damage, as measured by the percentage of leaf area covered by STB lesions, is distinct from resistance that affects pathogen reproduction, as measured by the density of pycnidia produced within lesions. We tested this hypothesis using a collection of 335 elite European winter wheat cultivars that was naturally infected by a diverse population of Zymoseptoria tritici in a replicated field experiment...
December 6, 2017: Phytopathology
https://www.readbyqxmd.com/read/29195043/grotthuss-transport-of-iodide-in-emim-i3-ionic-crystal
#3
Jesse Gatten McDaniel, Arun Yethiraj
Highly ionic environments can mediate unusual chemical reactions that would otherwise be considered impossible based on chemical intuition. For example, the formation of a chemical bond between two iodide anions to form a divalent polyiodide anion is seemingly prohibited due to Coulombic repulsion. Using ab initio molecular dynamics simulations, we show that in the 1-ethyl-3-methylimidazolium (EMIM)/I3 ionic crystal, the reactive formation of divalent and even trivalent polyiodide anions occurs with extremely small energetic barriers, due to the electrostatic field of the ionic lattice...
December 1, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29182348/solvation-of-the-guanidinium-ion-in-pure-aqueous-environments-a-theoretical-study-from-an-ab-initio-based-polarizable-force-field
#4
Céline Houriez, Michael Mautner, Michel Masella
We report simulation results regarding the hydration process of the guanidinium cation in water droplets and in bulk liquid water, at a low concentration of 0.03 M, performed using a polarizable approach to model both water/water and ion/water interactions. In line with earlier theoretical studies, our simulations show a preferential orientation of guanidinium at water/vacuum interfaces, i.e. a parallel orientation of the guanidinium plane to the aqueous surface. In an apparent contradiction with earlier simulation studies, we show also that guanidinium has a stronger propensity for the cores of aqueous systems than the ammonium cation...
November 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29172460/n-phenyl-2-naphthylamine-as-a-novel-maldi-matrix-for-analysis-and-in-situ-imaging-of-small-molecules
#5
Huihui Liu, Yueming Zhou, Jiyun Wang, Caiqiao Xiong, Jinjuan Xue, Lingpeng Zhan, Zongxiu Nie
Due to its strong ultraviolet absorption, low background interference in the small molecular range, and salt tolerance capacity, N-Phenyl-2-naphthylamine (PNA) was developed as a novel matrix in the present study for analysis and imaging of small molecules by matrix-assisted laser desorption/ionization mass spectrometry time-of-fight (MALDI-TOF MS). The newly developed matrix displayed good performance in analysis a wide range of small molecule metabolites including free fatty acids, amino acids, peptides, antioxidants as well as phospholipids...
November 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29171140/safety-and-efficacy-of-autoantigen-specific-therapy-with-2-doses-of-alum-formulated-glutamate-decarboxylase-in-children-with-multiple-islet-autoantibodies-and-risk-for-type-1-diabetes-a-randomized-clinical-trial
#6
Helena Elding Larsson, Markus Lundgren, Berglind Jonsdottir, David Cuthbertson, Jeffrey Krischer
OBJECTIVE: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity. METHODS: In an investigator-initiated, double-blind, placebo-controlled clinical trial, non-diabetic children aged 4 to 17.9 years with autoantibodies to glutamate decarboxylase (GADA) and at least one of insulinoma-associated protein 2, insulin or zinc-transporter 8, were randomized, stratified by 2 or ≥3 islet autoantibodies, to 2 injections of 20 μg GAD-Alum or placebo, 30 days apart...
November 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29165866/assessing-enclosure-design-and-husbandry-practices-for-successful-keeping-and-breeding-of-the-burmese-brow-antlered-deer-eld-s-deer-rucervus-eldii-thamin-in-european-zoos
#7
Ellis L Wall, Matt Hartley
The endangered Burmese brow antlered deer (Rucervus eldii thamin) is a medium sized tropical cervid kept in a number of European zoos. Studbook data and anecdotal reports have suggested that this species suffers from poor reproductive success and relatively high neonatal mortality in captivity. Questionnaires were sent to 10 European zoos, holding 91 (20.71.0) deer, in order to record information on husbandry practices and enclosure design. Studbook analysis was performed to determine reproductive success and mortality values at each of the zoos participating in the study...
May 2017: Zoo Biology
https://www.readbyqxmd.com/read/29150845/effect-of-sorbitol-on-the-pharmacokinetic-profile-of-lamivudine-oral-solution-in-adults-an-open-label-randomized-study
#8
Kimberly Adkison, Allen Wolstenholme, Yu Lou, Zhiping Zhang, Amy Eld, Teodora Perger, Harald Vangerow, Katy Hayward, Mark Shaefer, Cynthia McCoig
In children aged ≤4 years, the relative bioavailability of lamivudine oral solution was 37% lower than that of a tablet formulation. An open-label, 4-way crossover study was conducted in healthy adults to evaluate the effect of sorbitol, a common liquid excipient, on the pharmacokinetics of lamivudine oral solution (ClinicalTrials.gov identifier, NCT02634073). Sixteen subjects were randomized to 1 of 4 sequences consisting of 4 doses of lamivudine 300 mg (10 mg/mL) alone or with sorbitol 3.2, 10.2, or 13...
November 18, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29080005/correction-to-respiratory-infections-are-temporally-associated-with-initiation-of-type-1-diabetes-autoimmunity-the-teddy-study
#9
Maria Lönnrot, Kristian F Lynch, Helena Elding Larsson, Åke Lernmark, Marian J Rewers, Carina Törn, Brant R Burkhardt, Thomas Briese, William A Hagopian, Jin-Xiong She, Olli G Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Heikki Hyöty
The authors regret that the SNP in SH2B3 was incorrectly referred to as rs3184505 instead of rs3184504 on both mentions in this paper (Methods section and Table 1).
October 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/29073317/the-diagnostic-yield-of-noninvasive-microbiologic-sputum-sampling-in-a-cohort-of-patients-with-clinically-diagnosed-hospital-acquired-pneumonia
#10
Elliot L Naidus, Mary T Lasalvia, Edward R Marcantonio, Shoshana J Herzig
The clinical predictors of positive sputum culture have not been previously reported in hospital-acquired pneumonia (HAP), and data on yield of sputum culture in this setting are scant. Current Infectious Disease Society of America guidelines for HAP recommend noninvasive sputum sampling, though the data for this practice are limited. We assessed the yield of sputum culture in HAP cases at an academic medical center from January 2007 to July 2013. HAP cases were identifi ed by International Classifi cation of Diseases, Ninth Revision-Clinical Modifi cation codes for bacterial pneumonia and all cases were validated by chart review...
October 18, 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29061456/multi-layered-dura-reconstruction-after-thoracoscopic-microdiscectomy-technique-and-results
#11
Erwin M J Cornips
BACKGROUND: Anterior transthoracic approaches including thoracoscopic microdiscectomy (TMD) are the preferred technique for central, broad-based, calcified thoracic disc herniations (TDHs). Dural defects due to manipulation or transdural extension may create a potentially life-threatening subarachnoid-pleural fistula. We evaluate a fast, sutureless technique to reconstruct the dura. METHODS: We analyzed 476 anterior transthoracic approaches for TDHs (437 TMDs, 31 mini-thoracotomies, 7 transaxillary approaches, one sternotomy)...
October 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29053610/lab-on-chip-surface-enhanced-raman-analysis-by-aerosol-jet-printing-and-roll-to-roll-hot-embossing
#12
Anne Habermehl, Noah Strobel, Ralph Eckstein, Nico Bolse, Adrian Mertens, Gerardo Hernandez-Sosa, Carsten Eschenbaum, Uli Lemmer
Surface-enhanced Raman spectroscopy (SERS) combines the high specificity of Raman scattering with high sensitivity due to an enhancement of the electromagnetic field by metallic nanostructures. However, the tyical fabrication methods of SERS substrates suffer from low throughput and therefore high costs. Furthermore, point-of-care applications require the investigation of liquid solutions and thus the integration of the SERS substrate in a microfluidic chip. We present a roll-to-roll fabrication approach for microfluidics with integrated, highly efficient, surface-enhanced Raman scattering structures...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29053438/tailored-approach-to-surgical-exposure-reduces-surgical-site-complications-after-bilateral-lung-transplantation
#13
Stefan Elde, Stephen Huddleston, Scott Jackson, Rosemary Kelly, Sara Shumway, Gabriel Loor
BACKGROUND: We evaluated the effects of tailoring the operative approach on major surgical site complications and outcomes in lung transplant recipients. PATIENTS AND METHODS: Beginning in July 2013, bilateral lung transplants at a single institution were performed either through sternotomy or clamshell depending on proximity of hilar structures by computed tomography (CT), anticipated complexity, past surgical history, and surgeon experience. Patient demographics and outcomes were collected in the institution's Transplant Information Services (TIS)...
October 20, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29052687/association-between-early-life-antibiotic-use-and-the-risk-of-islet-or-celiac-disease-autoimmunity
#14
Kaisa M Kemppainen, Kendra Vehik, Kristian F Lynch, Helena Elding Larsson, Ronald J Canepa, Ville Simell, Sibylle Koletzko, Edwin Liu, Olli G Simell, Jorma Toppari, Anette G Ziegler, Marian J Rewers, Åke Lernmark, William A Hagopian, Jin-Xiong She, Beena Akolkar, Desmond A Schatz, Mark A Atkinson, Martin J Blaser, Jeffrey P Krischer, Heikki Hyöty, Daniel Agardh, Eric W Triplett
Importance: Evidence is lacking regarding the consequences of antibiotic use in early life and the risk of certain autoimmune diseases. Objective: To test the association between early-life antibiotic use and islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up for type 1 diabetes (T1D) or CD. Design, Setting, and Participants: HLA-genotyped newborns from Finland, Germany, Sweden, and the United States were enrolled in the prospective birth cohort of The Environmental Determinants of Diabetes in the Young (TEDDY) study between November 20, 2004, and July 8, 2010...
October 9, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29042802/utilization-of-fetal-fibronectin-testing-and-pregnancy-outcomes-among-women-with-symptoms-of-preterm-labor
#15
Sean C Blackwell, Erin M Sullivan, Allison A Petrilla, Xian Shen, Kathleen A Troeger, James D Byrne
OBJECTIVES: To identify pregnant health plan members triaged through the emergency department (ED), including labor and delivery (ELD) units, with symptoms of preterm labor (PTL), and evaluate the use of fetal fibronectin (fFN) testing; and to calculate the rate of hospitalization and timing of delivery in relation to the ED visit. METHODS: Retrospective cohort study using Medical Outcomes Research for Effectiveness and Economics Registry(®), a national multipayer claims database...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29019239/enhanced-dc-operated-electroluminescence-of-forwardly-aligned-%C3%A2-%C3%A2-p-mqw-n-ingan-nanorod-leds-via-dc-offset-ac-dielectrophoresis
#16
Yun Jae Eo, Gang Yeol Yoo, Hyelim Kang, Young Ki Lee, Chan Sik Kim, Ji Hye Oh, Keyong Nam Lee, Woong Kim, Young Rag Do
We introduce an orientation-controlled alignment process of p-GaN/InGaN multiquantum-well/n-GaN (p/MQW/n InGaN) nanorod light-emitting diodes (LEDs) by applying the direct current (DC) offset-alternating current (AC) or pulsed DC electric fields across interdigitated metal electrodes. The as-forwardly aligned p/MQW/n InGaN nanorod LEDs by a pulsed DC dielectrophoresis (DEP) assembly process improve the electroluminescence (EL) intensities by 1.8 times compared to the conventional AC DEP assembly process under DC electric field operation and exhibit an enhanced applied current and EL brightness in the current-voltage and EL intensity-voltage curves, which can be directly used as the fundamental data to construct DC-operated nanorod LED devices, such as LED areal surface lightings, scalable lightings (micrometers to inches) and formable surface lightings...
October 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28990147/pandemrix%C3%A2-vaccination-is-not-associated-with-increased-risk-of-islet-autoimmunity-or-type-1-diabetes-in-the-teddy-study-children
#17
Helena Elding Larsson, Kristian F Lynch, Maria Lönnrot, Michael J Haller, Åke Lernmark, William A Hagopian, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Marian J Rewers, Heikki Hyöty
AIMS/HYPOTHESIS: During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes. METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes...
October 9, 2017: Diabetologia
https://www.readbyqxmd.com/read/28941965/gestational-respiratory-infections-interacting-with-offspring-hla-and-ctla-4-modifies-incident-%C3%AE-cell-autoantibodies
#18
Kristian F Lynch, Hye-Seung Lee, Carina Törn, Kendra Vehik, Jeffrey P Krischer, Helena Elding Larsson, Michael J Haller, William A Hagopian, Marian J Rewers, Jin-Xiong She, Olli G Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Heikki Hyöty, Ezio Bonifacio, Åke Lernmark
β-cell autoantibodies against insulin (IAA), GAD65 (GADA) and IA-2 (IA-2A) precede onset of childhood type 1 diabetes (T1D). Incidence of the first appearing β-cell autoantibodies peaks at a young age and is patterned by T1D-associated genes, suggesting an early environmental influence. Here, we tested if gestational infections and interactions with child's human leukocyte antigen (HLA) and non-HLA genes affected the appearance of the first β-cell autoantibody. Singletons of mothers without diabetes (n = 7472) with T1D-associated HLA-DR-DQ genotypes were prospectively followed quarterly through the first 4 years of life, then semiannually until age 6 years, using standardized autoantibody analyses...
September 20, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28854632/rapid-evolution-of-primate-type-2-immune-response-factors-linked-to-asthma-susceptibility
#19
Matthew F Barber, Elliott M Lee, Hayden Griffin, Nels C Elde
Host immunity pathways evolve rapidly in response to antagonism by pathogens. Microbial infections can also trigger excessive inflammation that contributes to diverse autoimmune disorders including asthma, lupus, diabetes, and arthritis. Definitive links between immune system evolution and human autoimmune disease remain unclear. Here we provide evidence that several components of the type 2 immune response pathway have been subject to recurrent positive selection in the primate lineage. Notably, substitutions in the central immune regulator IL13 correspond to a polymorphism linked to asthma susceptibility in humans...
June 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28832417/2016-scct-str-guidelines-for-coronary-artery-calcium-scoring-of-noncontrast-noncardiac-chest-ct-scans-a-report-of-the-society-of-cardiovascular-computed-tomography-and-society-of-thoracic-radiology
#20
Harvey S Hecht, Paul Cronin, Michael J Blaha, Matthew J Budoff, Ella A Kazerooni, Jagat Narula, David Yankelevitz, Suhny Abbara
The Society of Cardiovascular Computed Tomography (SCCT) and the Society of Thoracic Radiology (STR) have jointly produced this document. Experts in this subject have been selected from both organizations to examine subject-specific data and write this guideline in partnership. A formal literature review, weighing the strength of evidence has been performed. When available, information from studies on cost was considered. Computed tomography (CT) acquisition, CAC scoring methodologies and clinical outcomes are the primary basis for the recommendations in this guideline...
September 2017: Journal of Thoracic Imaging
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