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https://www.readbyqxmd.com/read/29042802/utilization-of-fetal-fibronectin-testing-and-pregnancy-outcomes-among-women-with-symptoms-of-preterm-labor
#1
Sean C Blackwell, Erin M Sullivan, Allison A Petrilla, Xian Shen, Kathleen A Troeger, James D Byrne
OBJECTIVES: To identify pregnant health plan members triaged through the emergency department (ED), including labor and delivery (ELD) units, with symptoms of preterm labor (PTL), and evaluate the use of fetal fibronectin (fFN) testing; and to calculate the rate of hospitalization and timing of delivery in relation to the ED visit. METHODS: Retrospective cohort study using Medical Outcomes Research for Effectiveness and Economics Registry(®), a national multipayer claims database...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29019239/enhanced-dc-operated-electroluminescence-of-forwardly-aligned-p-mqw-n-ingan-nanorod-leds-via-dc-offset-ac-dielectrophoresis
#2
Yun Jae Eo, Gang Yeol Yoo, Hyelim Kang, Youngki Lee, Chan Sik Kim, Ji Hye Oh, Keyong Nam Lee, Woong Kim, Young Rag Do
We introduce orientation-controlled alignment process of p-GaN/InGaN multi quantum-well/n-GaN (p/MQW/n InGaN) nanorod light-emitting diodes (LEDs) by applying direct-current (DC) offset alternating-current (AC) or pulsed DC electric fields across interdigitated metal electrodes. The as-forwardly aligned p/MQW/n InGaN nanorod LEDs by a pulsed DC dielectrophoresis (DEP) assembly process improve the electroluminescence (EL) intensities by 1.8 times compared to the conventional AC DEP assembly process under DC electric field operation and exhibit an enhanced applied current and EL brightness in the current-voltage and EL intensity-voltage curves that can be directly used as fundamental data to construct DC-operated nanorod LED devices, such as LED areal surface lightings, scalable lightings (micrometers to inches) and formable surface lightings...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28990147/pandemrix%C3%A2-vaccination-is-not-associated-with-increased-risk-of-islet-autoimmunity-or-type-1-diabetes-in-the-teddy-study-children
#3
Helena Elding Larsson, Kristian F Lynch, Maria Lönnrot, Michael J Haller, Åke Lernmark, William A Hagopian, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Marian J Rewers, Heikki Hyöty
AIMS/HYPOTHESIS: During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes. METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes...
October 9, 2017: Diabetologia
https://www.readbyqxmd.com/read/28941965/gestational-respiratory-infections-interacting-with-offspring-hla-and-ctla-4-modifies-incident-%C3%AE-cell-autoantibodies
#4
Kristian F Lynch, Hye-Seung Lee, Carina Törn, Kendra Vehik, Jeffrey P Krischer, Helena Elding Larsson, Michael J Haller, William A Hagopian, Marian J Rewers, Jin-Xiong She, Olli G Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Heikki Hyöty, Ezio Bonifacio, Åke Lernmark
β-cell autoantibodies against insulin (IAA), GAD65 (GADA) and IA-2 (IA-2A) precede onset of childhood type 1 diabetes (T1D). Incidence of the first appearing β-cell autoantibodies peaks at a young age and is patterned by T1D-associated genes, suggesting an early environmental influence. Here, we tested if gestational infections and interactions with child's human leukocyte antigen (HLA) and non-HLA genes affected the appearance of the first β-cell autoantibody. Singletons of mothers without diabetes (n = 7472) with T1D-associated HLA-DR-DQ genotypes were prospectively followed quarterly through the first 4 years of life, then semiannually until age 6 years, using standardized autoantibody analyses...
September 20, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28854632/rapid-evolution-of-primate-type-2-immune-response-factors-linked-to-asthma-susceptibility
#5
Matthew F Barber, Elliott M Lee, Hayden Griffin, Nels C Elde
Host immunity pathways evolve rapidly in response to antagonism by pathogens. Microbial infections can also trigger excessive inflammation that contributes to diverse autoimmune disorders including asthma, lupus, diabetes, and arthritis. Definitive links between immune system evolution and human autoimmune disease remain unclear. Here we provide evidence that several components of the type 2 immune response pathway have been subject to recurrent positive selection in the primate lineage. Notably, substitutions in the central immune regulator IL13 correspond to a polymorphism linked to asthma susceptibility in humans...
June 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28832417/2016-scct-str-guidelines-for-coronary-artery-calcium-scoring-of-noncontrast-noncardiac-chest-ct-scans-a-report-of-the-society-of-cardiovascular-computed-tomography-and-society-of-thoracic-radiology
#6
Harvey S Hecht, Paul Cronin, Michael J Blaha, Matthew J Budoff, Ella A Kazerooni, Jagat Narula, David Yankelevitz, Suhny Abbara
The Society of Cardiovascular Computed Tomography (SCCT) and the Society of Thoracic Radiology (STR) have jointly produced this document. Experts in this subject have been selected from both organizations to examine subject-specific data and write this guideline in partnership. A formal literature review, weighing the strength of evidence has been performed. When available, information from studies on cost was considered. Computed tomography (CT) acquisition, CAC scoring methodologies and clinical outcomes are the primary basis for the recommendations in this guideline...
September 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28814073/multielectron-effects-in-the-strong-field-sequential-ionization-of-aligned-ch3i-molecules
#7
Sizuo Luo, Wenhui Hu, Jiaqi Yu, Xiaokai Li, Lanhai He, Chuncheng Wang, Fuchun Liu, Dajun Ding
Strong field sequential ionization of symmetric-top CH3I molecules is studied experimentally by using a combined method of femtosecond laser-induced impulsive alignment and time-of-flight mass spectrometry. Both alignment- and angular-dependent ion yields have been measured, and the sequential ionization of a multielectron has been discussed. It is found that the maximum ionization occurs when the polarization of probe laser is perpendicular to the internuclear axis of molecules, and the signal of fragment ion peaks at the polarization of the probe laser is parallel to the internuclear axis of molecules...
August 24, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28800278/the-antidepressant-like-effect-of-ocimum-basilicum-in-an-animal-model-of-depression
#8
S S Ali, M G Abd El Wahab, N N Ayuob, M Suliaman
We investigated the efficacy of Ocimum basilicum (OB) essential oils for treating depression related behavioral, biochemical and histopathological changes caused by exposure to chronic unpredictable mild stress (CUMS) in mice and to explore the mechanism underlying the pathology. Male albino mice were divided into four groups: controls; CUMS; CUMS plus fluoxetine, the antidepressant administered for pharmacological validation of OB; and CUMS plus OB. Behavioral tests included the forced swim test (FST), elevated plus-maze (EPM) and the open field test (OFT); these tests were performed at the end of the experiment...
August 11, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28796612/eld-net-an-efficient-deep-learning-architecture-for-accurate-saliency-detection
#9
Gayoung Lee, Yu-Wing Tai, Junmo Kim
Recent advances in saliency detection have utilized deep learning to obtain high-level features to detect salient regions in scenes. In this paper, we propose ELD-Net, a unified deep learning framework for accurate and efficient saliency detection. We show that hand-crafted features can provide complementary information to enhance saliency detection that uses only high-level features. Our method uses both low-level and high-level features for saliency detection. High-level features are extracted using GoogLeNet, and low-level features evaluate the relative importance of a local region using its differences from other regions in an image...
August 9, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28796576/antibody-affinity-against-2009-a-h1n1-influenza-and-pandemrix-vaccine-nucleoproteins-differs-between-childhood-narcolepsy-patients-and-controls
#10
Alexander Lind, Eva Freyhult, Anita Ramelius, Tomas Olsson, Lisen Arnheim-Dahlström, Favelle Lamb, Mohsen Khademi, Aditya Ambati, Markus Maeurer, Izaura Lima Bomfim, Katharina Fink, Malin Fex, Carina Törn, Helena Elding Larsson, Åke Lernmark
Increased narcolepsy incidence was observed in Sweden following the 2009 influenza vaccination with Pandemrix(®). A substitution of the 2009 nucleoprotein for the 1934 variant has been implicated in narcolepsy development. The aims were to determine (a) antibody levels toward wild-type A/H1N1-2009[A/California/04/2009(H1N1)] (NP-CA2009) and Pandemrix-[A/Puerto Rico/8/1934(H1N1)] (NP-PR1934) nucleoproteins in 43 patients and 64 age-matched controls; (b) antibody affinity in reciprocal competitive assays in 11 childhood narcolepsy patients compared with 21 age-matched controls; and (c) antibody levels toward wild-type A/H1N1-2009[A/California/04/2009(H1N1)] (H1N1 NS1), not a component of the Pandemrix vaccine...
October 2017: Viral Immunology
https://www.readbyqxmd.com/read/28791479/using-external-lumbar-csf-drainage-to-treat-communicating-external-hydrocephalus-in-adult-patients-after-acute-traumatic-or-non-traumatic-brain-injury
#11
Romain Manet, Jean-François Payen, Romain Guerin, Orianne Martinez, Serge Hautefeuille, Gilles Francony, Laurent Gergelé
BACKGROUND: Despite various treatments to control intracranial pressure (ICP) after brain injury, patients may present a late onset of high ICP or a poor response to medications. External lumbar drainage (ELD) can be considered a therapeutic option if high ICP is due to communicating external hydrocephalus. We aimed at describing the efficacy and safety of ELD used in a cohort of traumatic or non-traumatic brain-injured patients. METHODS: In this multicentre retrospective analysis, patients had a delayed onset of high ICP after the initial injury and/or a poor response to ICP treatments...
August 8, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28774110/electroconductive-composites-from-polystyrene-block-copolymers-and-cu-alumina-filler
#12
QuratulAin Nadeem, Tasneem Fatima, Pepijn Prinsen, Aziz Ur Rehman, Rohama Gill, Rashid Mahmood, Rafael Luque
Technological advancements and development of new materials may lead to the manufacture of sustainable energy-conducting devices used in the energy sector. This research attempts to fabricate novel electroconductive and mechanically stable nanocomposites via an electroless deposition (ELD) technique using electrically insulating materials. Metallic Cu is coated onto Al₂O₃ by ELD, and the prepared filler is then integrated (2-14 wt %) into a matrix of polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene-graft-maleic anhydride (PS-b-(PE-r-B)-b-PS-g-MA)...
December 7, 2016: Materials
https://www.readbyqxmd.com/read/28772389/optically-clear-and-resilient-free-form-%C3%A2%C2%B5-optics-3d-printed-via-ultrafast-laser-lithography
#13
Linas Jonušauskas, Darius Gailevičius, Lina Mikoliūnaitė, Danas Sakalauskas, Simas Šakirzanovas, Saulius Juodkazis, Mangirdas Malinauskas
We introduce optically clear and resilient free-form micro-optical components of pure (non-photosensitized) organic-inorganic SZ2080 material made by femtosecond 3D laser lithography (3DLL). This is advantageous for rapid printing of 3D micro-/nano-optics, including their integration directly onto optical fibers. A systematic study of the fabrication peculiarities and quality of resultant structures is performed. Comparison of microlens resiliency to continuous wave (CW) and femtosecond pulsed exposure is determined...
January 2, 2017: Materials
https://www.readbyqxmd.com/read/28770319/respiratory-infections-are-temporally-associated-with-initiation-of-type-1-diabetes-autoimmunity-the-teddy-study
#14
Maria Lönnrot, Kristian F Lynch, Helena Elding Larsson, Åke Lernmark, Marian J Rewers, Carina Törn, Brant R Burkhardt, Thomas Briese, William A Hagopian, Jin-Xiong She, Olli G Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Heikki Hyöty
AIMS/HYPOTHESIS: Respiratory infections and onset of islet autoimmunity are reported to correlate positively in two small prospective studies. The Environmental Determinants of Diabetes in the Young (TEDDY) study is the largest prospective international cohort study on the environmental determinants of type 1 diabetes that regularly monitors both clinical infections and islet autoantibodies. The aim was to confirm the influence of reported respiratory infections and to further characterise the temporal relationship with autoantibody seroconversion...
August 2, 2017: Diabetologia
https://www.readbyqxmd.com/read/28755385/building-and-validating-a-prediction-model-for-pediatric-type-1-diabetes-risk-using-next-generation-targeted-sequencing-of-class-ii-hla-genes
#15
Lue Ping Zhao, Annelie Carlsson, Helena Elding Larsson, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Eva Örtqvist, Chul-Woo Pyo, Hamid Bolouri, Michael Zhao, Wyatt C Nelson, Daniel E Geraghty, Åke Lernmark
AIM: It is of interest to predict possible lifetime risk of type diabetes (T1D) in young children for recruiting high-risk subjects into longitudinal studies of effective prevention strategies. METHODS: Utilizing a case-control study in Sweden, we applied a recently developed next generation targeted sequencing (NGTS) technology to genotype class II genes, and applied an object-oriented regression (OOR) to build and validate a prediction model for T1D. RESULTS: In the training set, estimated risk scores were significantly different between patients and controls (P=8...
July 29, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28753701/reprocessing-of-single-use-endoscopic-variceal-band-ligation-devices-a-pilot-study
#16
Kavel Visrodia, Abdul Haseeb, Yuri Hanada, Kelly M Pennington, Magdalen Clemens, Paul J Pearce, Pritish K Tosh, Bret T Petersen, Mark D Topazian
Background and study aims The preferred management of bleeding esophageal varices includes endoscopic band ligation. Endoscopic ligation devices (ELDs) are expensive and designed for single use, limiting their uptake in developing countries. We aimed to assess the efficacy of reprocessing ELDs using terminal microbial cultures and adenosine triphosphate (ATP) testing. Materials and methods ELDs were recovered after clinical use and their components (cap, handle, and cord) were subjected to reprocessing...
July 28, 2017: Endoscopy
https://www.readbyqxmd.com/read/28742056/monte-carlo-simulations-of-skin-exposure-to-electromagnetic-field-from-10-ghz-to-1-thz
#17
Kensuke Sasaki, Maya Mizuno, Kanako Wake, Soichi Watanabe
In this study, we present an assessment of human-body exposure to an electromagnetic eld at frequencies ranging from 10 GHz to 1 THz. The energy absorption and temperature elevation were assessed by solving boundary value problems of the one-dimensional Maxwell equations and a bioheat equation for a multilayer plane model. Dielectric properties were measured in vitro at frequencies of up to 1 THz at body temperature. A Monte Carlo simulation was conducted to assess variations of the transmittance into a skin surface and temperature elevation inside a body by considering the variation of the tissue thickness due to individual differences among human bodies...
July 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28717842/selective-matrix-metalloproteinase-inhibition-increases-breaking-strength-and-reduces-anastomotic-leakage-in-experimentally-obstructed-colon
#18
Peter-Martin Krarup, Mikkel Eld, Lars Nannestad Jorgensen, Mark Berner Hansen, Magnus S Ågren
PURPOSE: Colonic obstruction causes loss of collagen and impairment of anastomotic integrity by matrix metalloproteinases (MMPs). Unexpectedly, pharmacological MMP inhibition increased anastomotic leakage (AL) in obstructed colon possibly due to the non-selective nature of these compounds and the experimental model applied. We therefore studied the effects of selective MMP inhibition on the healing of anastomoses in colon obstructed by a novel laparoscopic technique. METHODS: Left colon was obstructed in 38 male Sprague-Dawley rats (226-284 g)...
July 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28716440/removal-notice-to-617-candida-colonization-is-associated-with-improved-survival-after-lung-transplant-j-heart-lung-transplant-36-2017-s238
#19
J S Green, R Brown, T Umeda, K Rudser, S Elde, J M Roberts, M I Hertz, G Loor, J H Young, R Tomic
No abstract text is available yet for this article.
August 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28703137/platelet-function-is-modified-by-common-sequence-variation-in-megakaryocyte-super-enhancers
#20
Romina Petersen, John J Lambourne, Biola M Javierre, Luigi Grassi, Roman Kreuzhuber, Dace Ruklisa, Isabel M Rosa, Ana R Tomé, Heather Elding, Johanna P van Geffen, Tao Jiang, Samantha Farrow, Jonathan Cairns, Abeer M Al-Subaie, Sofie Ashford, Antony Attwood, Joana Batista, Heleen Bouman, Frances Burden, Fizzah A Choudry, Laura Clarke, Paul Flicek, Stephen F Garner, Matthias Haimel, Carly Kempster, Vasileios Ladopoulos, An-Sofie Lenaerts, Paulina M Materek, Harriet McKinney, Stuart Meacham, Daniel Mead, Magdolna Nagy, Christopher J Penkett, Augusto Rendon, Denis Seyres, Benjamin Sun, Salih Tuna, Marie-Elise van der Weide, Steven W Wingett, Joost H Martens, Oliver Stegle, Sylvia Richardson, Ludovic Vallier, David J Roberts, Kathleen Freson, Lorenz Wernisch, Hendrik G Stunnenberg, John Danesh, Peter Fraser, Nicole Soranzo, Adam S Butterworth, Johan W Heemskerk, Ernest Turro, Mikhail Spivakov, Willem H Ouwehand, William J Astle, Kate Downes, Myrto Kostadima, Mattia Frontini
Linking non-coding genetic variants associated with the risk of diseases or disease-relevant traits to target genes is a crucial step to realize GWAS potential in the introduction of precision medicine. Here we set out to determine the mechanisms underpinning variant association with platelet quantitative traits using cell type-matched epigenomic data and promoter long-range interactions. We identify potential regulatory functions for 423 of 565 (75%) non-coding variants associated with platelet traits and we demonstrate, through ex vivo and proof of principle genome editing validation, that variants in super enhancers play an important role in controlling archetypical platelet functions...
July 13, 2017: Nature Communications
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