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https://www.readbyqxmd.com/read/29905509/the-siludrain-trial-a-prospective-randomized-controlled-trial-comparing-standard-versus-silver-impregnated-lumbar-drains
#1
Martin Jakobs, Sabrina Klein, Tatjana Eigenbrod, Andreas W Unterberg, Oliver W Sakowitz
OBJECTIVE Catheter-associated cerebrospinal fluid (CSF) infection remains a serious event, especially for patients in neurocritical care units. The use of external ventricular drain (EVD) catheters impregnated with antimicrobial substances has led to a significant reduction of infection rates. This study was undertaken to compare the use of antimicrobial, silver-impregnated external lumbar drains (si-ELDs) and conventional ELDs. METHODS Patients with an indication for ELD placement were randomized to receive either a conventional or an si-ELD catheter...
June 15, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29777295/laser-debulking-or-tracheotomy-in-airway-management-prior-to-total-laryngectomy-for-t4a-laryngeal-cancer
#2
Djamil Semdaie, Fabienne Haroun, Odile Casiraghi, François Bidault, Stéphane Temam, François Janot, Philippe Gorphe
PURPOSE: Retrospective studies have shown that tracheotomy prior to total laryngectomy (TL) is associated with decreased survival. We sought to investigate whether this is due to higher local invasiveness associated with obstructive disease or whether it is the result of tracheotomy itself. METHODS: We reviewed patients with a T4a (AJCC 7th edition) laryngeal squamous-cell carcinoma treated with a primary TL followed by adjuvant radiotherapy between 2001 and 2013...
May 18, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29766906/n-type-rashba-spin-splitting-in-a-bilayer-inorganic-halide-perovskite-with-external-electric-field
#3
Xuejiao Chen, Lei Liu, Dezhen Shen
Here, we investigated the Rashba effect of the CsPbBr<sub>3</sub> bilayers under the external electric eld (EEF), with the first-principles calculations. For the PbBr<sub>2</sub> terminated bilayer, we found that only electrons experience the Rashba splitting under EEF, while holes do not. Such n-type Rashba effect can be ascribed to the surface relaxation effect that reverses the positions of the top valence bands. The n-type Rashba parameter can be tuned monotonically to the maximum of 0...
May 16, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29752553/influence-of-early-life-parental-severe-life-events-on-the-risk-of-type-1-diabetes-in-children-the-dipis-study
#4
Markus Lundgren, Katarina Ellström, Helena Elding Larsson
AIMS: Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study. METHODS: Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis...
May 12, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29742044/end-of-life-decision-making-in-palliative-care-and-recommendations-of-the-council-of-europe-qualitative-secondary-analysis-of-interviews-and-observation-field-notes
#5
Sandra Martins Pereira, Emília Fradique, Pablo Hernández-Marrero
BACKGROUND: End-of-life decisions (ELDs) are embedded in clinical, sociocultural, political, economic, and ethical concerns. In 2014, the Council of Europe (CoE) through its Committee on Bioethics launched the "Guide on the decision-making process regarding medical treatment in end-of-life situations," aiming at improving decision-making processes and empowering professionals in making ELDs. OBJECTIVE: To analyze if end-of-life decision making in palliative care (PC) is consistent with this Guide and to identify if disputed/controversial issues are part of current ELDs...
May 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29726846/tunable-surface-configuration-of-skyrmion-lattices-in-cubic-helimagnets
#6
Xuejin Wan, Yangfan Hu, Biao Wang
In bulk helimagnets, the presence of magnetic skyrmion lattices is always accompanied by a periodic stressfield due to the intrinsic magnetoelastic coupling. The release of this nontrivial stress eld at the surface causes a periodic displacement field, which characterizes a novel particle-like property of skyrmion: its surface configuration. Here, we derive the analytical solution of this displacement field for semi-infinite cubic helimagnet with the skyrmion magnetization approximated by the triple-Q representation...
May 4, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29724306/-clinical-analysis-of-40-patients-with-eosinophilic-lung-diseases-in-peking-union-medical-college-hospital
#7
Xu Dong Zhang, Hai Hong Gong, Jin Ming Gao
Objective To summarize the clinical features of eosinophilic lung diseases(ELD). Methods We retrospectively analyzed the clinical manifestations,laboratory findings,accessory examination results,and pathology of 40 patients who were diagnosed with ELD and hospitalized in Peking Union Medical College Hospital from January 2013 to December 2016.Results There were 19 males and 21 females,and the average age was(48.58±18.25) years.The diagnoses included allergic bronchopulmonary aspergillosis(n=20),eosinophilic granulomatosis with polyangiitis(also known as churg-strauss syndrome)(n=10),chronic eosinophilic pneumonia(n=8),parasitic infection(n=1),and drug-induced eosinophilic pneumonia(n=1)...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29709186/aacid-the-anisotropy-of-the-asymmetric-magnetically-induced-current-density-tensor
#8
Guglielmo Monaco, Riccardo Zanasi
Molecular magnetic properties, such as the magnetizability, the magnetic shielding, and the current strength, all stem from the symmetric current density tensor. The anisotropy of that tensor, previously dened from its symmetric component only, is a scalar eld expected to bear useful information on molecular structure. A more general anisotropy has here been dened, considering the full asymmetric tensor and its eigen-values in the complex plane. Computations on few prototypical aromatic molecules show that the anisotropy of the full tensor highlights previously missed structural features, and also changes in a more regular way with bond lengths, as compared to the already known anisotropy of the symmetric component of the tensor...
April 30, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29676236/monoamine-involvement-in-the-antidepressant-like-effect-of-%C3%AE-caryophyllene
#9
Danillo Ramos Oliveira, Dayane Moreira Silva, Iziara Ferreira Florentino, Adriane de Brito, James Oluwagbamigbe Fajemiroye, Daiany Priscilla Bueno Silva, Fabio da Rocha, Elson Alves Costa, Pablinny Galdino De Carvalho
This study was conducted to evaluate the antidepressant-like activity of sesquiterpene compound β-caryophyllene (BCP) for the possible contribution of the monoamine and hippocampal levels of brain-derived neurotrophic factor (BDNF). Male albino Swiss mice were subjected to the forced swimming test after acute treatment and to the tail suspension test after repeated treatment. Hippocampal levels of BDNF were assayed by enzyme-linked immunosorbent assay. The anti-immobility effect of BCP was reverted by pretreatment with inhibitor of catecholamines α-methyl-p-tyrosine (100 mg/kg, i...
April 20, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29672623/impaired-vibrotactile-sense-in-children-and-adolescents-with-type-1-diabetes-signs-of-peripheral-neuropathy
#10
Erik Ising, Lars B Dahlin, Helena Elding Larsson
OBJECTIVE: To investigate whether multi-frequency vibrometry can identify individuals with elevated vibration perception thresholds (VPTs), reflecting impaired vibrotactile sense, among children and adolescents with type 1 diabetes. METHODS: In 72 pediatric patients with type 1 diabetes, VPTs were evaluated for seven frequencies on two sites of the hand, and five frequencies on two sites of the foot. Z-scores, based on previously collected reference data, were calculated...
2018: PloS One
https://www.readbyqxmd.com/read/29669652/nursing-in-the-sandbox-a-lived-experience
#11
Glennena Haynes-Smith
Despite an extensive career in military nursing, the author's deployment to Iraq included experiences for which no amount of education could have prepared her: the extreme living conditions, harrowing battlefi eld injuries, and ethical dilemmas she confronted.
April 1, 2018: Creative Nursing
https://www.readbyqxmd.com/read/29652671/exploring-proximity-effects-and-large-depth-of-field-in-helium-ion-beam-lithography-large-area-dense-patterns-and-tilted-surface-exposure
#12
Ranveig Flatabø, Akshay Agarwal, Richard Hobbs, Martin M Greve, Bodil Holst, Karl K Berggren
Helium ion beam lithography (HIL) is an emerging nanofabrication technique. It benefits from a reduced interaction volume compared to that of an electron beam of similar energy, and hence reduced long-range scattering (proximity effect), higher resist sensitivity and potentially higher resolution. Furthermore, the small angular spread of the helium ion beam gives rise to a large depth of field. This should enable patterning on tilted and curved surfaces without the need of any additional adjustments, such as laser-auto focus...
July 6, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29626585/the-better-diabetes-diagnosis-bdd-study-a-review-of-a-nationwide-prospective-cohort-study-in-sweden
#13
REVIEW
M Persson, C Becker, H Elding Larsson, Å Lernmark, G Forsander, S A Ivarsson, J Ludvigsson, U Samuelsson, C Marcus, A Carlsson
The incidence of type 1 diabetes (T1D) in Sweden is one of the highest in the world. However, the possibility of other types of diabetes must also be considered. In addition, individuals with T1D constitute a heterogeneous group. A precise classification of diabetes is a prerequisite for optimal outcome. For precise classification, knowledge on the distribution of genetic factors, biochemical markers and clinical features in individuals with new onset of diabetes is needed. The Better Diabetes Diagnosis (BDD), is a nationwide study in Sweden with the primary aim to facilitate a more precise classification and diagnosis of diabetes in order to enable the most adequate treatment for each patient...
June 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29611592/reduction-of-ormaplatin-by-an-extended-series-of-thiols-unravels-a-remarkable-correlation
#14
Jingran Dong, Hongwu Tian, Changying Song, Tiesheng Shi, Lars I Elding
Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(iv) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between log kRS- and the thiol dissociation constants pKRSH is disclosed: log kRS- = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS- denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.
April 24, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29607913/eldecalcitol-increases-bone-mass-in-patients-with-turner-syndrome-who-have-insufficient-bone-mass-acquisition-after-estrogen-replacement-therapy
#15
Taku Tsuburai, Tomomi Nakamura, Hiromi Yoshikata, Etsuko Miyagi, Hideya Sakakibara
Most patients with Turner syndrome (TS) exhibit amenorrhea due to premature ovarian failure. Therefore, estrogen replacement therapy (ERT) is required; however, even after undergoing ERT, it is not rare for bone mass acquisition to be insufficient. This study was conducted in two stages, involving a cross-sectional and a prospective interventional study. We recruited 52 TS patients undergoing ERT due to amenorrhea (categorized into low (LB group; n = 23), and normal (NB group; n = 29) bone mass groups) and 7 TS patients who maintained ovarian function (spontaneous menstrual cycle group (MC group)) as controls...
March 31, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29593337/end-of-life-decision-making-across-cancer-types-results-from-a-nationwide-retrospective-survey-among-treating-physicians
#16
Mariëtte N Verkissen, Dirk Houttekier, Joachim Cohen, Rik Schots, Kenneth Chambaere, Luc Deliens
BACKGROUND: The treatment of advanced cancer often involves potentially life-shortening end-of-life decisions (ELDs). This study aimed to examine the prevalence and characteristics of ELDs in different cancer types. METHODS: A nationwide death certificate study was conducted based on a large random sample of all deaths in Flanders, Belgium, between 1 January and 30 June 2013. All cancer deaths were selected (n = 2392). Attending physicians were sent a questionnaire about ELDs and the preceding decision-making process...
May 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29587908/-to-explore-clinical-value-of-single-port-video-assisted-thoracoscopic-surgery-in-elderly-patients-with-non-small-cell-lung-cancer-lobectomy-segmentectomy-and-lobectomy-vs-segmentectomy
#17
Lin Huang, Bin Zheng, Chun Chen, Wei Zheng, Yong Zhu, Chaohui Guo
BACKGROUND: The morbidity of lung cancer has long been the highest in cancer. Stage I, stage II and partly of stage III non-small cell lung cancer (NSCLC) are mainly treated by surgery. Lobectomy and segmentectomy both are common lung resection methods. Video-assisted thoracoscopic surgery (VATS) has been widely used in clinical, and the application of single-portvideo-assisted thoracoscopic surgery (SP VATS) has gradually been recognized and accepted by professors. With increasing degree of eldly in society, eldly patients already have become inceasingly difficulties in the diagnosis and treatment of NSCLC...
April 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29577538/family-adjustment-to-diabetes-diagnosis-in-children-can-participation-in-a-study-on-type-1-diabetes-genetic-risk-be-helpful
#18
Laura B Smith, Xiang Liu, Suzanne Bennett Johnson, Roy Tamura, Helena Elding Larsson, Simi Ahmed, Riitta Veijola, Michael J Haller, Beena Akolkar, William A Hagopian, Marian J Rewers, Jeffrey Krischer, Andrea K Steck
BACKGROUND: Diagnosis of type 1 diabetes often causes a negative psychological impact on families. We examined whether parents and children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study differ in their psychological adjustment to diabetes diagnosis compared to children diagnosed with diabetes in the community. METHODS: TEDDY follows 8676 children at genetic risk for type 1 diabetes from birth. Fifty-four TEDDY children diagnosed with diabetes and 54 age-matched community control children diagnosed with diabetes were enrolled...
March 26, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29550293/do-physicians-discuss-end-of-life-decisions-with-family-members-a-mortality-follow-back-study
#19
Maarten Vermorgen, Aline De Vleminck, Luc Deliens, Dirk Houttekier, Nele Spruytte, Chantal Van Audenhove, Joachim Cohen, Kenneth Chambaere
OBJECTIVE: Deaths from chronic illness are often preceded by a potentially life-shortening end-of-life decision (ELD). Involving family in these ELDs may have psychosocial benefits for them and the dying person. This study aims to examine how often ELDs are discussed with relatives of the dying person and which characteristics determine their involvement in those ELDs. METHODS: A questionnaire survey was conducted in 2013 among physicians attending a large, stratified and representative sample of deaths (n = 6188) in Flanders...
March 2, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29531651/elotuzumab-for-the-treatment-of-relapsed-or-refractory-multiple-myeloma-with-special-reference-to-its-modes-of-action-and-slamf7-signaling
#20
REVIEW
Masafumi Taniwaki, Mihoko Yoshida, Yosuke Matsumoto, Kazuho Shimura, Junya Kuroda, Hiroto Kaneko
Elotuzumab, targeting signaling lymphocytic activation molecule family 7 (SLAMF7), has been approved in combination with lenalidomide and dexamethasone (ELd) for relapsed/refractory multiple myeloma (MM) based on the findings of the phase III randomized trial ELOQUENT-2 (NCT01239797). Four-year follow-up analyses of ELOQUENT-2 have demonstrated that progression-free survival was 21% in ELd versus 14% in Ld. Elotuzumab binds a unique epitope on the membrane IgC2 domain of SLAMF7, exhibiting a dual mechanism of action: natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC) and enhancement of NK cell activity...
2018: Mediterranean Journal of Hematology and Infectious Diseases
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