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https://www.readbyqxmd.com/read/28717842/selective-matrix-metalloproteinase-inhibition-increases-breaking-strength-and-reduces-anastomotic-leakage-in-experimentally-obstructed-colon
#1
Peter-Martin Krarup, Mikkel Eld, Lars Nannestad Jorgensen, Mark Berner Hansen, Magnus S Ågren
PURPOSE: Colonic obstruction causes loss of collagen and impairment of anastomotic integrity by matrix metalloproteinases (MMPs). Unexpectedly, pharmacological MMP inhibition increased anastomotic leakage (AL) in obstructed colon possibly due to the non-selective nature of these compounds and the experimental model applied. We therefore studied the effects of selective MMP inhibition on the healing of anastomoses in colon obstructed by a novel laparoscopic technique. METHODS: Left colon was obstructed in 38 male Sprague-Dawley rats (226-284 g)...
July 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28716440/removal-notice-to-617-candida-colonization-is-associated-with-improved-survival-after-lung-transplant-j-heart-lung-transplant-36-2017-s238
#2
J S Green, R Brown, T Umeda, K Rudser, S Elde, J M Roberts, M I Hertz, G Loor, J H Young, R Tomic
No abstract text is available yet for this article.
August 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28703137/platelet-function-is-modified-by-common-sequence-variation-in-megakaryocyte-super-enhancers
#3
Romina Petersen, John J Lambourne, Biola M Javierre, Luigi Grassi, Roman Kreuzhuber, Dace Ruklisa, Isabel M Rosa, Ana R Tomé, Heather Elding, Johanna P van Geffen, Tao Jiang, Samantha Farrow, Jonathan Cairns, Abeer M Al-Subaie, Sofie Ashford, Antony Attwood, Joana Batista, Heleen Bouman, Frances Burden, Fizzah A Choudry, Laura Clarke, Paul Flicek, Stephen F Garner, Matthias Haimel, Carly Kempster, Vasileios Ladopoulos, An-Sofie Lenaerts, Paulina M Materek, Harriet McKinney, Stuart Meacham, Daniel Mead, Magdolna Nagy, Christopher J Penkett, Augusto Rendon, Denis Seyres, Benjamin Sun, Salih Tuna, Marie-Elise van der Weide, Steven W Wingett, Joost H Martens, Oliver Stegle, Sylvia Richardson, Ludovic Vallier, David J Roberts, Kathleen Freson, Lorenz Wernisch, Hendrik G Stunnenberg, John Danesh, Peter Fraser, Nicole Soranzo, Adam S Butterworth, Johan W Heemskerk, Ernest Turro, Mikhail Spivakov, Willem H Ouwehand, William J Astle, Kate Downes, Myrto Kostadima, Mattia Frontini
Linking non-coding genetic variants associated with the risk of diseases or disease-relevant traits to target genes is a crucial step to realize GWAS potential in the introduction of precision medicine. Here we set out to determine the mechanisms underpinning variant association with platelet quantitative traits using cell type-matched epigenomic data and promoter long-range interactions. We identify potential regulatory functions for 423 of 565 (75%) non-coding variants associated with platelet traits and we demonstrate, through ex vivo and proof of principle genome editing validation, that variants in super enhancers play an important role in controlling archetypical platelet functions...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28696334/recent-advances-in-heart-sound-analysis
#4
Gari D Clifford, Chengyu Liu, Benjamin E Moody, José Millet Roig, Samuel E Schmidt, Qiao Li, Ikaro Silva, Roger G Mark
Heart sounds have been widely studied and have been demonstrated to have value for detecting pathologies in clinical applications. Over the last few decades, the use of heart sound signals has become increasingly uncommon and its practice in modern medicine somewhat diminished, although research into automated analysis has continued. Unfortunately, a comparative analyses of algorithms in the literature have been hindered by the lack of high-quality, rigorously validated, and standardized open databases of heart sound recordings...
July 11, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28694858/local-application-of-vibration-in-motor-rehabilitation-scientific-and-practical-considerations
#5
Daniela Poenaru, Delia Cinteza, Irina Petrusca, Liliana Cioc, Dan Dumitrascu
Vibration stimulates specific receptors, cutaneous and musculo-tendinous. The aff erent impulses travel through spinal neurons to thalamus and cortical structures. The local muscular response to a vibration is a tonic vibratory refl ex. This refl ex depends on many factors: frequency, amplitude, and tendon and muscle length. Based upon this refl ex, vibration produced alteration of isometric and isotonic contraction, fl exibility, spasticity. Many studies investigated facilitator eff ects on movement in stroke patients and spinal cord injuries...
September 2016: Mædica
https://www.readbyqxmd.com/read/28694856/social-determinant-factors-and-their-relationship-with-nutritional-pattern-in-cardiovascular-patients-after-hospital-discharge
#6
Hassan Nazari, Davoud Vahabzadeh, Saeed Beygh Mohammadi, Leila Zarei, Masoud Ghahramani
INTRODUCTION: Several evidences suggest that it will be possible to reduce the risk of cardiovascular diseases by modifying its risk factors. Current study designed for identifying some social determinant factors and their relationship with nutritional pa! ern in cardiovascular patients a" er hospital discharge. METHODS: This cross-sectional study was conducted on 385 cardiovascular discharged patients from an university specialized heart educational hospital. Patients were included by simple sampling methods...
September 2016: Mædica
https://www.readbyqxmd.com/read/28685118/atomic-structure-of-mg-based-metallic-glass-investigated-with-neutron-diffraction-reverse-monte-carlo-modeling-and-electron-microscopy
#7
Rafał Babilas, Dariusz Łukowiec, Laszlo Temleitner
The structure of a multicomponent metallic glass, Mg65Cu20Y10Ni5, was investigated by the combined methods of neutron diffraction (ND), reverse Monte Carlo modeling (RMC) and high-resolution transmission electron microscopy (HRTEM). The RMC method, based on the results of ND measurements, was used to develop a realistic structure model of a quaternary alloy in a glassy state. The calculated model consists of a random packing structure of atoms in which some ordered regions can be indicated. The amorphous structure was also described by peak values of partial pair correlation functions and coordination numbers, which illustrated some types of cluster packing...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28677826/elotuzumab-plus-lenalidomide-dexamethasone-for-relapsed-or-refractory-multiple-myeloma-eloquent-2-follow-up-and-post-hoc-analyses-on-progression-free-survival-and-tumour-growth
#8
Meletios A Dimopoulos, Sagar Lonial, Darrell White, Philippe Moreau, Antonio Palumbo, Jesus San-Miguel, Ofer Shpilberg, Kenneth Anderson, Sebastian Grosicki, Ivan Spicka, Adam Walter-Croneck, Hila Magen, Maria-Victoria Mateos, Andrew Belch, Donna Reece, Meral Beksac, Eric Bleickardt, Valerie Poulart, Jennifer Sheng, Oumar Sy, Jessica Katz, Anil Singhal, Paul Richardson
The randomized phase III ELOQUENT-2 study (NCT01239797) evaluated the efficacy and safety of elotuzumab + lenalidomide/dexamethasone (ELd) versus lenalidomide/dexamethasone (Ld) in relapsed/refractory multiple myeloma. ELd reduced the risk of disease progression/death by 30% versus Ld (hazard ratio [HR] 0·70). Median time from diagnosis was 3·5 years. We present extended 3-year follow-up data. Endpoints included progression-free survival (PFS), overall response rate (ORR) and interim overall survival (OS)...
July 5, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28670721/age-is-not-a-bar-to-pci-insights-from-the-long-term-outcomes-from-off-site-pci-in-a-real-world-setting
#9
Robert T Gerber, Satpal S Arri, Mohamed O Mohamed, Gurpreet Dhillon, Alykhan Bandali, Idris Harding, Jeremy Gifford, Belinda Sandler, Ben Corbo, Eric McWilliams
OBJECTIVES: We sought to analyze the percutaneous coronary intervention (PCI) outcomes of very elderly patients (V. Eld. group, age >80 years) and compare their outcomes to a less elderly cohort (Eld. group, age 75-80 years) traditionally reported in the literature. BACKGROUND: Limited data exist on peri-procedural and long-term outcomes following PCI in the V. Eld. (age >80 years), with under-representation of this cohort in randomized controlled trials. These patients present with advanced complex coronary disease and multiple comorbidities...
July 2, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28653986/3d-qsar-and-molecular-docking-studies-on-the-tcpmca1-mediated-detoxification-of-scopoletin-and-coumarin-derivatives
#10
Qiu-Li Hou, Jin-Xiang Luo, Bing-Chuan Zhang, Gao-Fei Jiang, Wei Ding, Yong-Qiang Zhang
The carmine spider mite, Tetranychus cinnabarinus (Boisduval), is an economically important agricultural pest that is difficult to prevent and control. Scopoletin is a botanical coumarin derivative that targets Ca(2+)-ATPase to exert a strong acaricidal effect on carmine spider mites. In this study, the full-length cDNA sequence of a plasma membrane Ca(2+)-ATPase 1 gene (TcPMCA1) was cloned. The sequence contains an open reading frame of 3750 bp and encodes a putative protein of 1249 amino acids. The effects of scopoletin on TcPMCA1 expression were investigated...
June 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28652949/cerebrospinal-fluid-total-tau-is-increased-in-normal-pressure-hydrocephalus-patients-who-undergo-successful-lumbar-drain-trials
#11
Geoffrey Baird, Thomas J Montine, Jason J Chang, Shu-Ching Hu, Anthony M Avellino
BACKGROUND: Idiopathic normal pressure hydrocephalus (INPH) is a neurologic disease that affects <1% of those aged >65 years, but is difficult to distinguish from other diseases that present in this age group, such as Alzheimer's disease. Large volume lumbar puncture and an external lumbar drain trial (ELD) are used to make a clinical diagnosis of INPH, but the accuracy of ELD is suspected. OBJECTIVE: To investigate proteomic cerebrospinal fluid (CSF) biomarker patterns in patients with INPH undergoing ELD to develop a quantitative diagnostic...
May 22, 2017: Curēus
https://www.readbyqxmd.com/read/28650578/intake-of-energy-and-protein-is-associated-with-overweight-risk-at-age-5-5-years-results-from-the-prospective-teddy-study
#12
Andreas Beyerlein, Ulla M Uusitalo, Suvi M Virtanen, Kendra Vehik, Jimin Yang, Christiane Winkler, Mathilde Kersting, Sibylle Koletzko, Desmond Schatz, Carin Andrén Aronsson, Helena Elding Larsson, Jeffrey P Krischer, Anette-G Ziegler, Jill M Norris, Sandra Hummel
OBJECTIVE: The associations of energy, protein, carbohydrate, and fat intake with weight status up to the age of 5.5 years were prospectively assessed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. METHODS: Food record data (over 3 days) and BMI measurements between 0.25 and 5.5 years were available from 5,563 children with an increased genetic risk for type 1 diabetes followed from shortly after birth. Odds ratios (ORs) were calculated for overweight and obesity by previous intake of energy, protein, carbohydrate, and fat with adjustment for potential confounders...
June 26, 2017: Obesity
https://www.readbyqxmd.com/read/28647957/-long-term-effectiveness-of-transvaginal-high-uterosacral-ligament-suspension
#13
L Duan, Y X Lu, W J Shen, X Liu, J X Liu, Y H Zhang, J Ge, Y Zhao, K Niu, W Y Wang
Objective: To assess the long-term effectiveness of the transvaginal high uterosacral ligament suspension (HUS) in women suffering from advanced pelvic organ prolapse (POP). Methods: A retrospective review of records identified 118 women who underwent transvaginal HUS with or without additional concomitant anterior and (or) posterior repairs from June 2003 to August 2009 in the First Affiliated Hospital, General Hospital of People's Liberation Army. Of 118 women, 104 women completed the follow-up during study period; these 104 women were analysed...
June 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28639437/ultrasound-assisted-green-economic-synthesis-of-hydroxyapatite-nanoparticles-using-eggshell-bio-waste-and-study-of-mechanical-and-biological-properties-for-orthopaedic-applications
#14
Vijay H Ingole, Kamal Hany Hussein, Anil A Kashale, Kalyani Ghule, Tomaž Vuherer, Vanja Kokol, Jia-Yaw Chang, Yong-Chien Ling, Aruna Vinchurkar, Hom N Dhakal, Anil V Ghule
Nanostructured hydroxyapatite (HAp) is most favorable candidate biomaterial for bone tissue engineering because of its bioactive and osteoconductive properties. Herein, we report for the first time ultrasound assisted facile and economic approach for the synthesis of nanocrystalline hydroxyapatite (Ca10 (PO4 )6 (OH)2 ) using recycled eggshell bio-waste referred as EHAp. The process involves the reaction of eggshell bio-waste as a source of calcium and ammonium dihydrogen orthophosphate as a phosphate source...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28624935/eldecalcitol-an-active-vitamin-d3-derivative-prevents-trabecular-bone-loss-and-bone-fragility-in-type-i-diabetic-model-rats
#15
Satoshi Takeda, Mitsuru Saito, Sadaoki Sakai, Kenji Yogo, Keishi Marumo, Koichi Endo
Diabetes mellitus is known to adversely affect the bones and be associated with increased fracture risk. We examined whether eldecalcitol (ELD), an active vitamin D3 derivative, could inhibit the diabetic bone loss in streptozotocin-induced type I diabetic rats. ELD (10, 20, or 40 ng/kg), alfacalcidol (ALF; 25, 50, or 100 ng/kg), or vehicle was administered 5 times per week for 12 weeks from 1 week after diabetes induction. Normal control rats received the vehicle. Bone turnover markers, bone mineral density (BMD), and biomechanical strength of the lumbar spine and femur were measured, and bone histomorphometry was performed...
June 17, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28621793/kinetics-and-mechanism-of-oxidation-of-the-anti-tubercular-prodrug-isoniazid-and-its-analog-by-iridium-iv-as-models-for-biological-redox-systems
#16
Jingran Dong, Yanli Ren, Sufang Sun, Jiao Yang, Chunxia Nan, Hongmei Shi, Jianzhong Xu, Jie Duan, Tiesheng Shi, Lars I Elding
A complex reaction mechanism of oxidation of the anti-tubercular prodrug isoniazid (isonicotinic hydrazide, INH) by [IrCl6](2-) as a model for redox processes of such drugs in biological systems has been studied in aqueous solution as a function of pH between 0 and 8.5. Similar experiments have been performed with its isomer nicotinic hydrazide (NH). All reactions are overall second-order, first-order in [IrCl6](2-) and hydrazide, and the observed second-order rate constants k' have been determined as a function of pH...
June 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28599966/effect-of-american-college-of-surgeons-trauma-center-designation-on-outcomes-measurable-benefit-at-the-extremes-of-age-and-injury
#17
Michael D Grossman, Jay A Yelon, Lisa Szydiak
BACKGROUND: ACS verification is believed to provide benefits for trauma patients but is associated with direct costs. STUDY DESIGN: One-year retrospective review of the NTDB for 2012. Patients separated into three age groups; Pediatric (PEDS) 0-14, Adult 15-65, and elderly (ELD), >65. We analyzed 2 injury severity cohorts, ISS 9-74 (ALL) and ISS 25-74 (MAJ). Multiple logistic regression to determine significance of ACS verification on mortality and major complications, controlling for age, ISS, shock, GCS, gender, age, co-morbidities and mechanism...
May 18, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28580398/histomorphometric-analysis-of-minimodeling-in-the-vertebrae-in-postmenopausal-patients-treated-with-anti-osteoporotic-agents
#18
Tomohiro Hikata, Tomoka Hasegawa, Keisuke Horiuchi, Nobuyuki Fujita, Akio Iwanami, Kota Watanabe, Ken Ishii, Masaya Nakamura, Norio Amizuka, Morio Matsumoto
Minimodeling is a type of focal bone formation that is characterized by the lack of precedent bone erosion by osteoclasts. Although this form of bone formation has been described for more than a decade, how anti-osteoporotic agents that are currently used in clinical practice affect the kinetics of minimodeling is not fully understood. We performed a bone morphometric analysis using human vertebral specimens collected from postmenopausal patients who underwent spinal surgery. Patients were divided into three groups according to osteoporosis medication; non-treated, Eldecalcitol (ELD, a vitamin D derivative that has recently been approved to treat patients with osteoporosis in Japan)-treated, and bisphosphonate-treated groups...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28556782/identification-of-interstitial-like-defects-in-a-computer-model-of-glassy-aluminum
#19
E V Goncharova, R A Konchakov, A S Makarov, N P Kobelev, V A Khonik
Computer simulation shows that glassy aluminum produced by rapid melt quenching contains a significant number of 'defects' similar to dumbbell (split) interstitials in the crystalline state. Although these 'defects' do not have any clear topological pattern as opposed to the crystal, they can be uniquely identified with the same properties which are characteristic of these defects in the crystalline structure, i.e. strong sensitivity to applied shear stress, specific local shear strain fields and distinctive low-/high-frequency peculiarities in the vibration spectra of 'defective' atoms...
May 30, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28531154/announcing-the-2017-pharmaceuticals-travel-award-for-young-post-doctoral-researchers
#20
EDITORIAL
Jean Jacques Vanden Eynde
Last year, for the first time in its history, our Journal was able to offer a travel grant of 800 CHF to a young researcher in the field of medicinal chemistry.
May 22, 2017: Pharmaceuticals
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