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https://www.readbyqxmd.com/read/29393447/simulated-microgravity-hampers-notch-signaling-in-the-fight-against-myocardial-ischemia%C3%A2-reperfusion-injury
#1
Shuai Jiang, Xing-Cheng Zhao, Bo Jiao, Zhi-Jie Yue, Zhi-Bin Yu
The gravitational field is an important determinant of cardiovascular function. Exposure to microgravity during spaceflight may lead to a series of maladaptive alterations in the cardiovascular system. The authors have previously demonstrated that microgravity can increase the susceptibility to myocardial ischemia‑reperfusion (IR) injury under simulated microgravity. Although Notch1 signaling protects against myocardial IR injury, whether Notch1 protects against myocardial IR injury under simulated weightlessness remains unknown...
January 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29383974/is-the-accuracy-of-preoperative-mri-stage-in-rectal-adenocarcinoma-influenced-by-tumour-height
#2
Laurids Østergaard Poulsen, Mette Karen Yilmaz, Lars Oddershede, Martin Bøgsted, Gitte Holt, Mikkel Eld, Ken Ljungmann, Ursula Gerda Falkmer
AIM: To our knowledge, no prior studies have addressed the possible effects of tumour height on the accuracy of preoperative magnetic resonance imaging (MRI)-based staging relative to postoperative histopathological assessments in patients with adenocarcinoma of the rectum (RC). This study aimed to investigate whether the accuracy of preoperative MRI stage in RC is influenced by tumour height. METHODS: A total of 489 consecutive RC patients scheduled for curative treatment between 2009 and 2013 were included...
January 31, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29273827/stimulation-of-intestinal-calcium-absorption-by-orally-administrated-vitamin-d3-compounds-a-prospective-open-label-randomized-trial-in-osteoporosis
#3
K Uenishi, M Tokiwa, S Kato, M Shiraki
Intestinal fractional calcium absorption (FCA) was assessed before and after vitamin D3 treatment. Serum 1,25(OH)2D concentration was significantly increased by plain vitamin D3 and reduced by eldecalcitol. The 1α hydroxyl calcidiol and eldecalcitol treatments increased FCA, which may be induced through direct stimulation of vitamin D receptors in the intestine. INTRODUCTION: To assess the effects of vitamin D3 compounds on intestinal FCA and calcium-regulating hormones in post-menopausal osteoporosis, a randomized open-label prospective study was conducted...
December 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29239797/autologous-breast-reconstruction-using-the-immediately-lipofilled-extended-latissimus-dorsi-flap
#4
N Johns, N Fairbairn, M Trail, A Ewing, L Yong, C Raine, J M Dixon
BACKGROUND: The latissimus dorsi flap is a popular choice for autologous breast reconstruction. To dramatically improve volume, we report our experience of using the immediately lipofilled extended latissimus dorsi (ELD) flap and show it as a valid option for autologous breast reconstruction. METHODS: Patients undergoing the procedure between December 2013 and June 2016 were included. Demographic, clinical and operative factors were analysed, together with in-hospital morbidity and duration of postoperative hospital stay...
November 24, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29234623/are-perinatal-events-risk-factors-for-childhood-thyroid-autoimmunity
#5
Berglind Jonsdottir, Markus Lundgren, Sara Wallengren, Åke Lernmark, Ida Jönsson, Helena Elding Larsson
Background: Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse. Objectives: The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study. Methods: Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29212397/growth-and-neurodevelopment-in-very-preterm-infants-receiving-a-high-enteral-volume-feeding-regimen-a-population-based-cohort-study
#6
Claus Klingenberg, Fredrik Kragh Muraas, Catherine Elde Isaksen, Tina Nilsen, Marte Torgersen, Cecilie Melum-Hansen
AIM: The aim of this study is to evaluate a feeding regimen routinely providing >180 ml/kg/d fortified human milk to very preterm infants and impact on in-hospital growth, osteopenia, and neurodevelopment. METHOD: Retrospective population-based descriptive study of infants <30-week gestation admitted within 24 h of birth and discharged during the 6-year period 2005-2010. Growth and neurodevelopment was assessed until 2 years corrected age, and cerebral palsy up to 4 years corrected age Results: Ninety-nine infants below 30-week gestation were admitted within 24 h of birth during the 6-year period, of which 84 (85%) survived to discharge...
December 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29210601/ranking-quantitative-resistance-to-septoria-tritici-blotch-in-elite-wheat-cultivars-using-automated-image-analysis
#7
Petteri Karisto, Andreas Hund, Kang Yu, Jonas Anderegg, Achim Walter, Fabio Mascher, Bruce A McDonald, Alexey Mikaberidze
Quantitative resistance is likely to be more durable than major gene resistance for controlling Septoria tritici blotch (STB) on wheat. Earlier studies hypothesized that resistance affecting the degree of host damage, as measured by the percentage of leaf area covered by STB lesions, is distinct from resistance that affects pathogen reproduction, as measured by the density of pycnidia produced within lesions. We tested this hypothesis using a collection of 335 elite European winter wheat cultivars that was naturally infected by a diverse population of Zymoseptoria tritici in a replicated field experiment...
December 6, 2017: Phytopathology
https://www.readbyqxmd.com/read/29195043/grotthuss-transport-of-iodide-in-emim-i3-ionic-crystal
#8
Jesse Gatten McDaniel, Arun Yethiraj
Highly ionic environments can mediate unusual chemical reactions that would otherwise be considered impossible based on chemical intuition. For example, the formation of a chemical bond between two iodide anions to form a divalent polyiodide anion is seemingly prohibited due to Coulombic repulsion. Using ab initio molecular dynamics simulations, we show that in the 1-ethyl-3-methylimidazolium (EMIM)/I3 ionic crystal, the reactive formation of divalent and even trivalent polyiodide anions occurs with extremely small energetic barriers, due to the electrostatic field of the ionic lattice...
December 1, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29182348/solvation-of-the-guanidinium-ion-in-pure-aqueous-environments-a-theoretical-study-from-an-ab-initio-based-polarizable-force-field
#9
Céline Houriez, Michael Mautner, Michel Masella
We report simulation results regarding the hydration process of the guanidinium cation in water droplets and in bulk liquid water, at a low concentration of 0.03 M, performed using a polarizable approach to model both water/water and ion/water interactions. In line with earlier theoretical studies, our simulations show a preferential orientation of guanidinium at water/vacuum interfaces, i.e. a parallel orientation of the guanidinium plane to the aqueous surface. In an apparent contradiction with earlier simulation studies, we show also that guanidinium has a stronger propensity for the cores of aqueous systems than the ammonium cation...
November 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29172460/n-phenyl-2-naphthylamine-as-a-novel-maldi-matrix-for-analysis-and-in-situ-imaging-of-small-molecules
#10
Huihui Liu, Yueming Zhou, Jiyun Wang, Caiqiao Xiong, Jinjuan Xue, Lingpeng Zhan, Zongxiu Nie
Due to its strong ultraviolet absorption, low background interference in the small molecular range, and salt tolerance capacity, N-Phenyl-2-naphthylamine (PNA) was developed as a novel matrix in the present study for analysis and imaging of small molecules by matrix-assisted laser desorption/ionization mass spectrometry time-of-fight (MALDI-TOF MS). The newly developed matrix displayed good performance in analysis a wide range of small molecule metabolites including free fatty acids, amino acids, peptides, antioxidants as well as phospholipids...
November 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29171140/safety-and-efficacy-of-autoantigen-specific-therapy-with-2-doses-of-alum-formulated-glutamate-decarboxylase-in-children-with-multiple-islet-autoantibodies-and-risk-for-type-1-diabetes-a-randomized-clinical-trial
#11
Helena Elding Larsson, Markus Lundgren, Berglind Jonsdottir, David Cuthbertson, Jeffrey Krischer
OBJECTIVE: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity. METHODS: In an investigator-initiated, double-blind, placebo-controlled clinical trial, non-diabetic children aged 4 to 17.9 years with autoantibodies to glutamate decarboxylase (GADA) and at least one of insulinoma-associated protein 2, insulin or zinc-transporter 8, were randomized, stratified by 2 or ≥3 islet autoantibodies, to 2 injections of 20 μg GAD-Alum or placebo, 30 days apart...
November 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29165866/assessing-enclosure-design-and-husbandry-practices-for-successful-keeping-and-breeding-of-the-burmese-brow-antlered-deer-eld-s-deer-rucervus-eldii-thamin-in-european-zoos
#12
Ellis L Wall, Matt Hartley
The endangered Burmese brow antlered deer (Rucervus eldii thamin) is a medium sized tropical cervid kept in a number of European zoos. Studbook data and anecdotal reports have suggested that this species suffers from poor reproductive success and relatively high neonatal mortality in captivity. Questionnaires were sent to 10 European zoos, holding 91 (20.71.0) deer, in order to record information on husbandry practices and enclosure design. Studbook analysis was performed to determine reproductive success and mortality values at each of the zoos participating in the study...
May 2017: Zoo Biology
https://www.readbyqxmd.com/read/29150845/effect-of-sorbitol-on-the-pharmacokinetic-profile-of-lamivudine-oral-solution-in-adults-an-open-label-randomized-study
#13
Kimberly Adkison, Allen Wolstenholme, Yu Lou, Zhiping Zhang, Amy Eld, Teodora Perger, Harald Vangerow, Katy Hayward, Mark Shaefer, Cynthia McCoig
In children aged ≤4 years, the relative bioavailability of lamivudine oral solution was 37% lower than that of a tablet formulation. An open-label, 4-way crossover study was conducted in healthy adults to evaluate the effect of sorbitol, a common liquid excipient, on the pharmacokinetics of lamivudine oral solution (ClinicalTrials.gov identifier, NCT02634073). Sixteen subjects were randomized to 1 of 4 sequences consisting of 4 doses of lamivudine 300 mg (10 mg/mL) alone or with sorbitol 3.2, 10.2, or 13...
November 18, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29080005/correction-to-respiratory-infections-are-temporally-associated-with-initiation-of-type-1-diabetes-autoimmunity-the-teddy-study
#14
Maria Lönnrot, Kristian F Lynch, Helena Elding Larsson, Åke Lernmark, Marian J Rewers, Carina Törn, Brant R Burkhardt, Thomas Briese, William A Hagopian, Jin-Xiong She, Olli G Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Heikki Hyöty
The authors regret that the SNP in SH2B3 was incorrectly referred to as rs3184505 instead of rs3184504 on both mentions in this paper (Methods section and Table 1).
October 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/29073317/the-diagnostic-yield-of-noninvasive-microbiologic-sputum-sampling-in-a-cohort-of-patients-with-clinically-diagnosed-hospital-acquired-pneumonia
#15
Elliot L Naidus, Mary T Lasalvia, Edward R Marcantonio, Shoshana J Herzig
The clinical predictors of positive sputum culture have not been previously reported in hospital-acquired pneumonia (HAP), and data on yield of sputum culture in this setting are scant. Current Infectious Disease Society of America guidelines for HAP recommend noninvasive sputum sampling, though the data for this practice are limited. We assessed the yield of sputum culture in HAP cases at an academic medical center from January 2007 to July 2013. HAP cases were identifi ed by International Classifi cation of Diseases, Ninth Revision-Clinical Modifi cation codes for bacterial pneumonia and all cases were validated by chart review...
January 1, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29061456/multi-layered-dura-reconstruction-after-thoracoscopic-microdiscectomy-technique-and-results
#16
Erwin M J Cornips
BACKGROUND: Anterior transthoracic approaches including thoracoscopic microdiscectomy (TMD) are the preferred technique for central, broad-based, calcified thoracic disc herniations (TDHs). Dural defects due to manipulation or transdural extension may create a potentially life-threatening subarachnoid-pleural fistula. We evaluate a fast, sutureless technique to reconstruct the dura. METHODS: We analyzed 476 anterior transthoracic approaches for TDHs (437 TMDs, 31 mini-thoracotomies, 7 transaxillary approaches, one sternotomy)...
October 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29053610/lab-on-chip-surface-enhanced-raman-analysis-by-aerosol-jet-printing-and-roll-to-roll-hot-embossing
#17
Anne Habermehl, Noah Strobel, Ralph Eckstein, Nico Bolse, Adrian Mertens, Gerardo Hernandez-Sosa, Carsten Eschenbaum, Uli Lemmer
Surface-enhanced Raman spectroscopy (SERS) combines the high specificity of Raman scattering with high sensitivity due to an enhancement of the electromagnetic field by metallic nanostructures. However, the tyical fabrication methods of SERS substrates suffer from low throughput and therefore high costs. Furthermore, point-of-care applications require the investigation of liquid solutions and thus the integration of the SERS substrate in a microfluidic chip. We present a roll-to-roll fabrication approach for microfluidics with integrated, highly efficient, surface-enhanced Raman scattering structures...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29053438/tailored-approach-to-surgical-exposure-reduces-surgical-site-complications-after-bilateral-lung-transplantation
#18
Stefan Elde, Stephen Huddleston, Scott Jackson, Rosemary Kelly, Sara Shumway, Gabriel Loor
BACKGROUND: We evaluated the effects of tailoring the operative approach on major surgical site complications and outcomes in lung transplant recipients. PATIENTS AND METHODS: Beginning in July 2013, bilateral lung transplants at a single institution were performed either through sternotomy or clamshell depending on proximity of hilar structures by computed tomography (CT), anticipated complexity, past surgical history, and surgeon experience. Patient demographics and outcomes were collected in the institution's Transplant Information Services (TIS)...
October 20, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29052687/association-between-early-life-antibiotic-use-and-the-risk-of-islet-or-celiac-disease-autoimmunity
#19
MULTICENTER STUDY
Kaisa M Kemppainen, Kendra Vehik, Kristian F Lynch, Helena Elding Larsson, Ronald J Canepa, Ville Simell, Sibylle Koletzko, Edwin Liu, Olli G Simell, Jorma Toppari, Anette G Ziegler, Marian J Rewers, Åke Lernmark, William A Hagopian, Jin-Xiong She, Beena Akolkar, Desmond A Schatz, Mark A Atkinson, Martin J Blaser, Jeffrey P Krischer, Heikki Hyöty, Daniel Agardh, Eric W Triplett
Importance: Evidence is lacking regarding the consequences of antibiotic use in early life and the risk of certain autoimmune diseases. Objective: To test the association between early-life antibiotic use and islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up for type 1 diabetes (T1D) or CD. Design, Setting, and Participants: HLA-genotyped newborns from Finland, Germany, Sweden, and the United States were enrolled in the prospective birth cohort of The Environmental Determinants of Diabetes in the Young (TEDDY) study between November 20, 2004, and July 8, 2010...
December 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29042802/utilization-of-fetal-fibronectin-testing-and-pregnancy-outcomes-among-women-with-symptoms-of-preterm-labor
#20
Sean C Blackwell, Erin M Sullivan, Allison A Petrilla, Xian Shen, Kathleen A Troeger, James D Byrne
OBJECTIVES: To identify pregnant health plan members triaged through the emergency department (ED), including labor and delivery (ELD) units, with symptoms of preterm labor (PTL), and evaluate the use of fetal fibronectin (fFN) testing; and to calculate the rate of hospitalization and timing of delivery in relation to the ED visit. METHODS: Retrospective cohort study using Medical Outcomes Research for Effectiveness and Economics Registry(®), a national multipayer claims database...
2017: ClinicoEconomics and Outcomes Research: CEOR
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