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JOURNAL ARTICLE
Bonita Libman, Tessalyn Morrison, Laura Haines, Juvena R Hitt, Amanda G Kennedy
No abstract text is available yet for this article.
November 27, 2023: Musculoskeletal Care
#22
JOURNAL ARTICLE
George P Valentine, Xinyi Lu, Evan S Childress, C Andrew Dolloff, Nathaniel P Hitt, Matthew A Kulp, Benjamin H Letcher, Kasey C Pregler, Jacob M Rash, Mevin B Hooten, Yoichiro Kanno
Climate change affects populations over broad geographic ranges due to spatially autocorrelated abiotic conditions known as the Moran effect. However, populations do not always respond to broad-scale environmental changes synchronously across a landscape. We combined multiple datasets for a retrospective analysis of time-series count data (5-28 annual samples per segment) at 144 stream segments dispersed over nearly 1,000 linear kilometers of range to characterize the population structure and scale of spatial synchrony across the southern native range of a coldwater stream fish (brook trout, Salvelinus fontinalis), which is sensitive to stream temperature and flow variations...
November 21, 2023: Global Change Biology
#23
JOURNAL ARTICLE
Jonathan Eisenberger, Shmuel Somer, Eilon Ram, Eyal Nachum, Jonathan Frogal, Shany Levin, Jacob Lavee, Leonid Sternik, Jeffrey Morgan
BACKGROUND: Unfractionated heparin is the preferred anticoagulant used during open heart surgeries, including left ventricular assist device (LVAD) implantation. In cases in which patients are heparin-induced thrombocytopenia positive (HIT+), the accepted practice has been to substitute heparin with bivalirudin. This practice may be associated with significant bleeding and adverse outcomes. OBJECTIVES: To review our experience with HIT+ patients who were heparin-induced thrombocytopenia with thrombosis negative (HITT-) and who underwent HeartMate 3 LVAD implantation using heparin intraoperatively rather than bivalirudin...
November 2023: Israel Medical Association Journal: IMAJ
#24
JOURNAL ARTICLE
Jonas Albers, Marina Nikolova, Angelika Svetlove, Nedal Darif, Matthew J Lawson, Thomas R Schneider, Yannick Schwab, Gleb Bourenkov, Elizabeth Duke
Here, high-throughput tomography (HiTT), a fast and versatile phase-contrast imaging platform for life-science samples on the EMBL beamline P14 at DESY in Hamburg, Germany, is presented. A high-photon-flux undulator beamline is used to perform tomographic phase-contrast acquisition in about two minutes which is linked to an automated data processing pipeline that delivers a 3D reconstructed data set less than a minute and a half after the completion of the X-ray scan. Combining this workflow with a sophisticated robotic sample changer enables the streamlined collection and reconstruction of X-ray imaging data from potentially hundreds of samples during a beam-time shift...
January 1, 2024: Journal of Synchrotron Radiation
#25
RANDOMIZED CONTROLLED TRIAL
Hitt Sharma, Sameer Parekh, Pramod Pujari, Sunil Shewale, Shivani Desai, Neerja Bhatla, Smita Joshi, Sharmila Pimple, Anand Kawade, Latha Balasubramani, Anitha Thomas, Vanita Suri, Sanjay Lalwani, Rajini Uday, Veena Kamath, Ranajit Mandal, A Rajeswar, Abraham Peedicayil, Usha Rani Poli, Dipanwita Banerjee, Rengaswamy Sankaranarayanan, Partha Basu, Richard Muwonge, Sunil Gairola, Vikas Dogar, Harish Rao, Umesh Shaligram
BACKGROUND: To meet global cervical cancer elimination efforts, a wider range of affordable and accessible vaccines against human papillomavirus (HPV) are needed. We aimed to evaluate the immunogenicity and safety of a quadrivalent HPV vaccine (targeting HPV types 6, 11, 16, and 18), developed and manufactured by the Serum Institute of India (SIIPL). Here we report outcomes in the 9-14 years cohort. METHODS: This randomised, active-controlled, phase 2/3 trial was conducted at 12 tertiary care hospitals across India...
December 2023: Lancet Oncology
#26
Jennifer R S Meadows, Jefrey M Kidd, Guo-Dong Wang, Heidi G Parker, Peter Z Schall, Matteo Bianchi, Matthew J Christmas, Katia Bougiouri, Reuben M Buckley, Christophe Hitte, Anthony K Nguyen, Chao Wang, Vidhya Jagannathan, Julia E Niskanen, Laurent A F Frantz, Meharji Arumilli, Sruthi Hundi, Kerstin Lindblad-Toh, Catarina Ginja, Kadek Karang Agustina, Catherine André, Adam R Boyko, Brian W Davis, Michaela Drögemüller, Xin-Yao Feng, Konstantinos Gkagkavouzis, Giorgos Iliopoulos, Alexander C Harris, Marjo K Hytönen, Daniela C Kalthof, Yan-Hu Liu, Petros Lymberakis, Nikolaos Poulakakis, Ana Elisabete Pires, Fernando Racimo, Fabian Ramos-Almodovar, Peter Savolainen, Semina Venetsani, Imke Tammen, Alexandros Triantafyllidis, Bridgett vonHoldt, Robert K Wayne, Greger Larson, Frank W Nicholas, Hannes Lohi, Tosso Leeb, Ya-Ping Zhang, Elaine A Ostrander
No abstract text is available yet for this article.
November 7, 2023: Genome Biology
#27
JOURNAL ARTICLE
Sarah Momin, Shahbaz Saad, Emily H Garmon, Kirby D Hitt, Michael R Fettiplace, Courtney Shaver, Michael P Hofkamp
BACKGROUND: We hypothesized that patients who received an adductor canal block (ACB) in the operating room following unilateral total knee arthroplasty would have a lower oral morphine milligram equivalent (MME) consumption during the postanesthesia care unit (PACU) phase 1 recovery period compared to patients who received an ACB in the PACU. METHODS: This was a retrospective cohort study of patients who underwent robotic-assisted unilateral total knee arthroplasty under general anesthesia between March 1, 2020, and February 28, 2021, and received postoperative ACB either in the operating room or the PACU...
2023: Proceedings of the Baylor University Medical Center
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JOURNAL ARTICLE
Inci Aydin, Marcus May, Fabio Pisano, Nontsikelelo Mpofu-Maetzig, Leander Grode, Sameer Parekh, Pramod Pujari, Sunil Shewale, Shivani Desai, Hitt Sharma, Harish Rao, Manish Gautam, Sunil Gairola, Umesh Shaligram
BACKGROUND: This study assessed the safety and immunogenicity of a new booster vaccine against tetanus, diphtheria, and pertussis manufactured by Serum Institute of India Pvt. Ltd (SIIPL Tdap). METHODS: The Phase II/III trial was randomized (2:1), observer blinded and active controlled. Healthy subjects aged 4-65 years received a single dose of either SIIPL Tdap or comparator Tdap vaccine (Boostrix®, GlaxoSmithKline, Belgium), and were followed-up for 30 days...
October 10, 2023: Vaccine
#29
JOURNAL ARTICLE
Naomi S Chaytor, Victoria R Trapani, Barbara H Braffett, Fonseca Lm, Gayle M Lorenzi, Rose A Gubitosi-Klug, Susan Hitt, Kaleigh Farrell, Alan M Jacobson, Christopher M Ryan
Objective: Adults with type 1 diabetes (T1D) face an increased risk for cognitive decline and dementia. Diabetes-related and vascular risk factors have been linked to cognitive decline using detailed neuropsychological testing; however, it is unclear if cognitive screening batteries can detect cognitive changes associated with aging in T1D. Method: 1,049 participants with T1D (median age 59 years; range 43-74) from the Diabetes Control and Complications Trial (DCCT), and the follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study, completed the NIH Toolbox Cognition Battery (NIHTB-C) and Montreal Cognitive Assessment (MoCA)...
October 9, 2023: Clinical Neuropsychologist
#30
JOURNAL ARTICLE
Antoine Barocas, Philippe Savard, Audrey Carlo, Thomas Lecompte, Emmanuel de Maistre
BACKGROUND: In case of heparin-induced thrombocytopenia (HIT), the switch to a non-heparin anticoagulant is mandatory, at a therapeutic dose. Such a treatment has limitations though, especially for patients with renal and/or hepatic failure. Candidate laboratory tests could detect the more coagulable HIT patients, for whom therapeutic anticoagulation would be the more justified. PATIENTS AND METHODS: This was a monocentre observational prospective study in which 111 patients with suspected HIT were included...
September 19, 2023: Thrombosis Journal
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JOURNAL ARTICLE
Brian D Hitt, Ankit Gupta, Ruhar Singh, Ting Yang, Joshua D Beaver, Ping Shang, Charles L White, Lukasz A Joachimiak, Marc I Diamond
Neurodegenerative tauopathies are caused by transition of tau protein from a monomer to a toxic aggregate. They include Alzheimer disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick disease (PiD). We have previously proposed that tau monomer exists in two conformational ensembles: an inert form (Mi ), which does not self-assemble; and seed-competent form (Ms ), which self-assembles and templates ordered assembly growth. We proposed that cis/trans isomerization of tau at P301, the site of dominant disease-associated S/L mis-sense mutations, might underlie the transition of wild-type tau to a seed-competent state...
September 13, 2023: Journal of Biological Chemistry
#32
REVIEW
Panteleimon Ekkekakis, Stuart J H Biddle
Nonadherence to and dropout from regular exercise and physical activity are important reasons why the field of exercise science has yet to fulfill its promise of improving public health on a global scale. Researchers have claimed that High-Intensity Interval Training (HIIT) is a feasible and sustainable exercise modality that may result in higher long-term adherence than moderate-intensity continuous exercise. If true, this would be a breakthrough discovery that could unlock the potential of exercise as a health-promoting intervention...
January 2023: Psychology of Sport and Exercise
#33
JOURNAL ARTICLE
Talia A Hitt, Tamara S Hannon, Sheela N Magge
Youth-onset type 2 diabetes is a growing epidemic with a rising incidence worldwide. Although the pathogenesis and diagnosis of youth-onset type 2 diabetes are similar to adult-onset type 2 diabetes, youth-onset type 2 diabetes is unique, with greater insulin resistance, insulin hypersecretion, and faster progression of pancreatic beta cell function decline. Individuals with youth-onset type 2 diabetes also develop complications at higher rates within short periods of time compared to adults with type 2 diabetes or youth with type 1 diabetes...
December 21, 2023: Journal of Clinical Endocrinology and Metabolism
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JOURNAL ARTICLE
Jennifer R S Meadows, Jeffrey M Kidd, Guo-Dong Wang, Heidi G Parker, Peter Z Schall, Matteo Bianchi, Matthew J Christmas, Katia Bougiouri, Reuben M Buckley, Christophe Hitte, Anthony K Nguyen, Chao Wang, Vidhya Jagannathan, Julia E Niskanen, Laurent A F Frantz, Meharji Arumilli, Sruthi Hundi, Kerstin Lindblad-Toh, Catarina Ginja, Kadek Karang Agustina, Catherine André, Adam R Boyko, Brian W Davis, Michaela Drögemüller, Xin-Yao Feng, Konstantinos Gkagkavouzis, Giorgos Iliopoulos, Alexander C Harris, Marjo K Hytönen, Daniela C Kalthoff, Yan-Hu Liu, Petros Lymberakis, Nikolaos Poulakakis, Ana Elisabete Pires, Fernando Racimo, Fabian Ramos-Almodovar, Peter Savolainen, Semina Venetsani, Imke Tammen, Alexandros Triantafyllidis, Bridgett vonHoldt, Robert K Wayne, Greger Larson, Frank W Nicholas, Hannes Lohi, Tosso Leeb, Ya-Ping Zhang, Elaine A Ostrander
BACKGROUND: The international Dog10K project aims to sequence and analyze several thousand canine genomes. Incorporating 20 × data from 1987 individuals, including 1611 dogs (321 breeds), 309 village dogs, 63 wolves, and four coyotes, we identify genomic variation across the canid family, setting the stage for detailed studies of domestication, behavior, morphology, disease susceptibility, and genome architecture and function. RESULTS: We report the analysis of > 48 M single-nucleotide, indel, and structural variants spanning the autosomes, X chromosome, and mitochondria...
August 15, 2023: Genome Biology
#35
JOURNAL ARTICLE
Michael Hitt, Andrew Norris, Andrei N Vedernikov
A series of N -aroyloxyquinuclidinium salts were prepared and used as reagents to perform efficient three-component Ritter-Mumm-type oxidative C-H imidation of donors of 1° and 2° benzylic C-H bonds used as limiting reagents with nitriles as a source of imide nitrogen under photocatalytic conditions; these reagents also exhibit somewhat lower reactivity toward cycloalkanes.
July 19, 2023: Organic Letters
#36
JOURNAL ARTICLE
Daiana Araujo Santana-Oliveira, Henrique Souza-Tavares, Aline Fernandes-da-Silva, Flávia Maria Silva-Veiga, Gustavo Casimiro-Lopes, Patricia Lisboa, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Gut dysbiosis impairs nonshivering thermogenesis (NST) in obesity. The anti-obesogenic effects of exercise training might involve the modulation of gut microbiota and its inflammatory signals to the brown adipose tissue (BAT). This study evaluated whether high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) prevent overweight through reduced gut-derived inflammatory signals to BAT in high-fat-fed mice. Sixty male C57BL/6 mice (3 months old) comprised six experimental groups, Control diet (C), C + HIIT (C-HIIT), C+ MICT (C-MICT), High-fat diet (HF), HF + HIIT (HF-HIIT), HF + MICT (HF-MICT)...
July 1, 2023: Journal of Endocrinology
#37
JOURNAL ARTICLE
Quinn T Storozynsky, Xuefei Han, Shae Komant, Kate C Agopsowicz, Kyle G Potts, Armin M Gamper, Roseline Godbout, David H Evans, Mary M Hitt
Glioblastoma (GBM) is a malignant brain cancer refractory to the current standard of care, prompting an extensive search for novel strategies to improve outcomes. One approach under investigation is oncolytic virus (OV) therapy in combination with radiotherapy. In addition to the direct cytocidal effects of radiotherapy, radiation induces cellular senescence in GBM cells. Senescent cells cease proliferation but remain viable and are implicated in promoting tumor progression. The interaction of viruses with senescent cells is nuanced; some viruses exploit the senescent state to their benefit, while others are hampered, indicating senescence-associated antiviral activity...
June 25, 2023: Cancers
#38
JOURNAL ARTICLE
Muzammil Rafique, Ole Geir Solberg, Lars Gullestad, Bjørn Bendz, Klaus Murbræch, Kari Nytrøen, Katrine Rolid, Ketil Lunde
OBJECTIVES: High-intensity interval training (HIT) improves peak oxygen consumption (VO2peak) in de novo heart transplant (HTx) recipients. It remains unclear whether this improvement early after HTx is solely dependent on peripheral adaptations, or due to a linked chain of central and peripheral adaptations. The objective of this study was to determine whether HIT results in structural and functional adaptations in the cardiovascular system. METHODS: Eighty-one de novo HTx recipients were randomly assigned to participate in either 9 months of supervised HIT or standard care exercise-based rehabilitation...
2023: BMJ Open Sport & Exercise Medicine
#39
JOURNAL ARTICLE
Georgia Potsi, Yu-Han Joseph Tsai, Austin Reese, Dasol Yoon, Jeremy L Hitt, Antonios Kouloumpis, Jin Suntivich, David A Muller, Thomas E Mallouk, Emmanuel P Giannelis
The structural characteristics of supports, such as surface area and type of porosity, affect the deposition of electrocatalysts and greatly influence their electrochemical performance in fuel cells. In this work, we use a series of high surface area hierarchical porous carbons (HPCs) with defined mesoporosity as model supports to study the deposition mechanism of Pt nanoparticles. The resulting electrocatalysts are characterized by several analytical techniques, and their electrochemical performance is compared to a state-of-the-art, commercial Pt/C system...
June 27, 2023: ACS Applied Materials & Interfaces
#40
JOURNAL ARTICLE
Vishal Rathod, Laxmikant Kadam, Manish Gautam, Prabhu Dasu Gumma, Kevin Marke, Cathy Asokanathan, Alex Douglas-Bardsley, Laura Hassell, Sachin Bhandare, Sumit Gupta, Sameer Parekh, Pramod Pujari, Harish Rao, Hitt Sharma, Umesh Shaligram, Sunil Gairola
BACKGROUND: Luminex bead-based assays offer multiplexing to test antibodies against multiple antigens simultaneously; however, this requires validation using internationally certified reference standards. Therefore, there is an urgent need to characterize existing reference standards for the standardization of multiplex immunoassays (MIAs). Here, we report the development and validation of an MIA for the simultaneous estimation of levels of human serum immunoglobulin G (IgG) antibodies for pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN), diphtheria toxoid (DT), and tetanus toxoid (TT)...
2023: Frontiers in Immunology
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