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https://www.readbyqxmd.com/read/27870061/re-annotation-improved-large-scale-assembly-and-establishment-of-a-catalogue-of-noncoding-loci-for-the-genome-of-the-model-brown-alga-ectocarpus
#1
Alexandre Cormier, Komlan Avia, Lieven Sterck, Thomas Derrien, Valentin Wucher, Gwendoline Andres, Misharl Monsoor, Olivier Godfroy, Agnieszka Lipinska, Marie-Mathilde Perrineau, Yves Van De Peer, Christophe Hitte, Erwan Corre, Susana M Coelho, J Mark Cock
The genome of the filamentous brown alga Ectocarpus was the first to be completely sequenced from within the brown algal group and has served as a key reference genome both for this lineage and for the stramenopiles. We present a complete structural and functional reannotation of the Ectocarpus genome. The large-scale assembly of the Ectocarpus genome was significantly improved and genome-wide gene re-annotation using extensive RNA-seq data improved the structure of 11 108 existing protein-coding genes and added 2030 new loci...
November 21, 2016: New Phytologist
https://www.readbyqxmd.com/read/27855238/adrenal-crisis-secondary-to-bilateral-adrenal-haemorrhage-after-hemicolectomy
#2
Anthony Logaraj, Venessa H M Tsang, Shahrir Kabir, Julian C Y Ip
: Adrenal haemorrhage is a rare cause of adrenal crisis, which requires rapid diagnosis, prompt initiation of parenteral hydrocortisone and haemodynamic monitoring to avoid hypotensive crises. We herein describe a case of bilateral adrenal haemorrhage after hemicolectomy in a 93-year-old female with high-grade colonic adenocarcinoma. This patient's post-operative recovery was complicated by an acute hypotensive episode, hypoglycaemia and syncope, and subsequent computed tomography (CT) scan of the abdomen revealed bilateral adrenal haemorrhage...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27849484/the-benefits-of-high-intensity-functional-training-fitness-programs-for-military-personnel
#3
Christopher K Haddock, Walker S C Poston, Katie M Heinrich, Sara A Jahnke, Nattinee Jitnarin
INTRODUCTION: High intensity functional training (HIFT) programs are designed to address multiple fitness domains, potentially providing improved physical and mental readiness in a changing operational environment. Programs consistent with HIFT principals such as CrossFit, SEALFIT and the US Marine Corps' High Intensity Tactical Training (HITT) are increasingly popular among military personnel. The goal of HIFT programs is to produce high levels of cardiorespiratory fitness, endurance and strength that exceed those achieved by following current physical activity recommendations...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27827454/novel-high-throughput-approach-for-purification-of-infectious-virions
#4
Kevin T James, Brad Cooney, Kate Agopsowicz, Mary Ann Trevors, Adil Mohamed, Don Stoltz, Mary Hitt, Maya Shmulevitz
Viruses are extensively studied as pathogens and exploited as molecular tools and therapeutic agents. Existing methods to purify viruses such as gradient ultracentrifugation or chromatography have limitations, for example demand for technical expertise or specialized equipment, high time consumption, and restricted capacity. Our laboratory explores mutations in oncolytic reovirus that could improve oncolytic activity, and makes routine use of numerous virus variants, genome reassortants, and reverse engineered mutants...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27787285/heparin-induced-thrombocytopenia-a-tremendous-opportunity-for-randomization
#5
Austin Lammers, Thomas DeLoughery, Vinay Prasad
Heparin-induced thrombocytopenia and thrombosis (HITT) is both life-threatening with a complex immune-mediated process and clinically challenging to diagnose and treat. What further complicates matters is that thrombocytopenia is a frequently encountered laboratory value but rarely results in clinical signs of HITT. Decades into its initial description, we have anticoagulants with a small therapeutic index and associated high cost. The diagnosis is sometimes equivocal given our current laboratory diagnostics, and can take days to confirm...
October 25, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27771534/neural-mechanisms-and-functional-correlates-of-altered-postural-responses-to-perturbed-standing-balance-with-chronic-low-back-pain
#6
Jesse V Jacobs, Carrie L Roy, Juvena R Hitt, Roman E Popov, Sharon M Henry
This study sought to determine the effects of chronic low back pain (LBP) on the cortical evoked potentials, muscle activation, and kinematics of postural responses to perturbations of standing balance. Thirteen subjects with chronic, recurrent, non-specific LBP and 13 subjects without LBP participated. The subjects responded to unpredictably timed postural perturbations while standing on a platform that randomly rotated either "toes up" or "toes down". Electroencephalography (EEG) was used to calculate the negative peak (N1) and subsequent positive peak (P2) amplitudes of the perturbation-evoked cortical potentials...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27738524/effects-of-a-single-session-of-high-intensity-interval-treadmill-training-on-corticomotor-excitability-following-stroke-implications-for-therapy
#7
Sangeetha Madhavan, James W Stinear, Neeta Kanekar
Objective. High intensity interval treadmill training (HIITT) has been gaining popularity for gait rehabilitation after stroke. In this study, we examined the changes in excitability of the lower limb motor cortical representation (M1) in chronic stroke survivors following a single session of HIITT. We also determined whether exercise-induced changes in excitability could be modulated by transcranial direct current stimulation (tDCS) enhanced with a paretic ankle skill acquisition task. Methods. Eleven individuals with chronic stroke participated in two 40-minute treadmill-training sessions: HIITT alone and HITT preceded by anodal tDCS enhanced with a skill acquisition task (e-tDCS+HIITT)...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27736111/the-practice-integration-profile-rationale-development-method-and-research
#8
C R Macchi, Rodger Kessler, Andrea Auxier, Juvena R Hitt, Daniel Mullin, Constance van Eeghen, Benjamin Littenberg
Insufficient knowledge exists regarding how to measure the presence and degree of integrated care. Prior estimates of integration levels are neither grounded in theory nor psychometrically validated. They provide scant guidance to inform improvement activities, compare integration efforts, discriminate among practices by degree of integration, measure the effect of integration on quadruple aim outcomes, or address the needs of clinicians, regulators, and policymakers seeking new models of health care delivery and funding...
October 13, 2016: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/27736110/development-and-validation-of-a-measure-of-primary-care-behavioral-health-integration
#9
Rodger S Kessler, Andrea Auxier, Juvena R Hitt, C R Macchi, Daniel Mullin, Constance van Eeghen, Benjamin Littenberg
Introduction: We developed the Practice Integration Profile (PIP) to measure the degree of behavioral health integration in clinical practices with a focus on primary care (PC). Its 30 items, completed by providers, managers, and staff, provide an overall score and 6 domain scores derived from the Lexicon of Collaborative Care. We describe its history and psychometric properties. Method: The PIP was tested in a convenience sample of practices. Linear regression compared scores across integration exemplars, PC with behavioral services, PC without behavioral services, and community mental health centers without PC...
October 13, 2016: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/27662878/bioinformatics-pipeline-for-transcriptome-sequencing-analysis
#10
Sarah Djebali, Valentin Wucher, Sylvain Foissac, Christophe Hitte, Evan Corre, Thomas Derrien
The development of High Throughput Sequencing (HTS) for RNA profiling (RNA-seq) has shed light on the diversity of transcriptomes. While RNA-seq is becoming a de facto standard for monitoring the population of expressed transcripts in a given condition at a specific time, processing the huge amount of data it generates requires dedicated bioinformatics programs. Here, we describe a standard bioinformatics protocol using state-of-the-art tools, the STAR mapper to align reads onto a reference genome, Cufflinks to reconstruct the transcriptome, and RSEM to quantify expression levels of genes and transcripts...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27575015/high-intensity-treadmill-training-improves-gait-ability-vo2peak-and-cost-of-walking-in-stroke-survivors-preliminary-results-of-a-pilot-randomized-controlled-trial
#11
Daniele Munari, Anna Pedrinolla, Nicola Smania, Alessandro Picelli, Marialuisa Gandolfi, Leopold Saltuari, Federico Schena
BACKGROUND: Stroke is a major cause of death and long-term disability across the globe. Previous studies have demonstrated the trainability of stroke survivors and documented beneficial effects of aerobic exercises on cardiovascular fitness and gait ability. AIM: The main aim of this study was to compare the effects of a high-intensity treadmill training (HITT) against low-intensity treadmill training (LITT) on gait ability, quality of life, cardiorespiratory fitness and cost of walking in chronic stroke subjects...
August 30, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27455037/dermocystidium-sp-infection-in-blue-ridge-sculpin-captured-in-maryland
#12
Vicki S Blazer, Nathaniel P Hitt, Craig D Snyder, Erin L Snook, Cynthia R Adams
Raised pale cysts were observed on Blue Ridge Sculpin Cottus caeruleomentum during stream fish community surveys in Catoctin Mountain Park, Maryland. When examined histologically, preserved sculpin exhibited multiple cysts containing spherical endospores with a refractile central body characteristic of Dermocystidium spp. Cysts were not observed on the gills or internally. The portion of the watershed in which affected sculpin were observed contained lower than expected numbers of sculpin, raising concerns about the population effects of this infection...
September 2016: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/27274578/numeracy-and-the-persuasive-effect-of-policy-information-and-party-cues
#13
Vittorio Mérola, Matthew P Hitt
Numeric political appeals represent a prevalent but overlooked domain of public opinion research. When can quantitative information change political attitudes, and is this change trumped by partisan effects? We analyze how numeracy-or individual differences in citizens' ability to process and apply numeric policy information-moderates the effectiveness of numeric political appeals on a moderately salient policy issue. Results show that those low in numeracy exhibit a strong party-cue effect, treating numeric information in a superficial and heuristic fashion...
2016: Public Opinion Quarterly
https://www.readbyqxmd.com/read/27257259/genomic-and-archaeological-evidence-suggest-a-dual-origin-of-domestic-dogs
#14
Laurent A F Frantz, Victoria E Mullin, Maud Pionnier-Capitan, Ophélie Lebrasseur, Morgane Ollivier, Angela Perri, Anna Linderholm, Valeria Mattiangeli, Matthew D Teasdale, Evangelos A Dimopoulos, Anne Tresset, Marilyne Duffraisse, Finbar McCormick, László Bartosiewicz, Erika Gál, Éva A Nyerges, Mikhail V Sablin, Stéphanie Bréhard, Marjan Mashkour, Adrian Bălăşescu, Benjamin Gillet, Sandrine Hughes, Olivier Chassaing, Christophe Hitte, Jean-Denis Vigne, Keith Dobney, Catherine Hänni, Daniel G Bradley, Greger Larson
The geographic and temporal origins of dogs remain controversial. We generated genetic sequences from 59 ancient dogs and a complete (28x) genome of a late Neolithic dog (dated to ~4800 calendar years before the present) from Ireland. Our analyses revealed a deep split separating modern East Asian and Western Eurasian dogs. Surprisingly, the date of this divergence (~14,000 to 6400 years ago) occurs commensurate with, or several millennia after, the first appearance of dogs in Europe and East Asia. Additional analyses of ancient and modern mitochondrial DNA revealed a sharp discontinuity in haplotype frequencies in Europe...
June 3, 2016: Science
https://www.readbyqxmd.com/read/27219106/risk-belief-and-attitude-formation-from-translated-scientific-messages-about-pfoa-an-environmental-risk-associated-with-breast-cancer
#15
Sandi W Smith, Rose Hitt, Jessica Russell, Samantha Nazione, Kami Silk, Charles K Atkin, David Keating
Evidence regarding possible environmental causes of breast cancer is advancing. Often, however, the public is not informed about these advances in a manner that is easily understandable. This research translates findings from biologists into messages at two literacy levels about perfluorooctanoic acid (PFOA), a possible environmental contributor to breast cancer. The Heuristic Systematic Model (HSM) was used to investigate how ability, motivation, and systematic and heuristic processing lead to risk beliefs and, ultimately, to negative attitudes for individuals receiving translated scientific messages about PFOA...
May 24, 2016: Health Communication
https://www.readbyqxmd.com/read/27151235/breast-cancer-gene-therapy-using-an-adenovirus-encoding-human-il-2-under-control-of-mammaglobin-promoter-enhancer-sequences
#16
S Chaurasiya, P Hew, P Crosley, D Sharon, K Potts, K Agopsowicz, M Long, C Shi, M M Hitt
Interleukin-2 (IL-2) has been used clinically for the treatment of some malignancies, but the toxicities associated with systemic IL-2 therapy are a major challenge. Here we have determined whether transcriptional targeting of IL-2 to breast cancer (BrCa) using an engineered human mammaglobin promoter/enhancer (MPE2) is a feasible option for reducing IL-2-associated toxicities while still achieving a meaningful antitumor effect. We have constructed nonreplicating adenovirus vectors encoding either a reporter gene (luciferase) or human IL-2 (hIL-2) complementary DNA under control of the MPE2 sequence, the murine cytomegalovirus immediate early (MCMV) promoter or the human telomerase reverse transcriptase (hTERT) promoter...
June 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27134308/bivalirudin-anticoagulation-for-a-pediatric-patient-with-heparin-induced-thrombocytopenia-and-thrombosis-requiring-cardiopulmonary-bypass-for-ventricular-assist-device-placement
#17
Katie H Faella, David Whiting, Francis Fynn-Thompson, Gregory S Matte
The direct thrombin inhibitor bivalirudin is an option for anticoagulation in patients with heparin induced thrombocytopenia (HIT) requiring cardiopulmonary bypass (CPB). There are a limited number of reports of pediatric patients in which bivalirudin has been used for anticoagulation for CPB. We present the case of an 11 year old male with acute onset heart failure secondary to idiopathic dilated cardiomyopathy that developed heparin induced thrombocytopenia with thrombosis (HITT). The patient was anticoagulated in the operating room with bivalirudin and placed on CPB for insertion of a HeartWare(®) Ventricular Assist Device (Heartware(®))...
March 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27132801/factors-affecting-hemoglobin-a1c-in-the-diagnosis-of-diabetes-and-prediabetes-in-youth
#18
Jennifer McGuire Hitt, Pedro Velasquez-Mieyer, Claudia Neira, Patricia Cowan
UNLABELLED: We sought to examine the correlation between variables and A1C levels to determine if prediction modeling could be used in the screening and diagnosis of diabetes and prediabetes in youth. We also sought to test relationships between A1C levels to insulin sensitivity indices and β-cell function indices. DESIGN AND METHODS: We performed a retrospective review of 904 medical records from youth deemed at-risk for the disease. We performed Pearson correlation, multiple regression, and simple regression testing to determine the relationship between variables and A1C levels...
September 2016: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/27128600/application-of-a-telecolposcopy-program-in-rural-settings
#19
Wilbur C Hitt, Gordon M Low, Christian E Lynch, C Heath Gauss, Everett F Magann, Curtis L Lowery, Hari Eswaran
BACKGROUND: Individuals in rural areas are often restricted by the amount of physicians' availability, thus limiting access to healthcare in those settings. INTRODUCTION: While Pap smear screening has increased across the United States, the rural South still reports high rates of cervical cancer and mortality. One solution to improve patient outcomes related to cervical cancer in rural settings is telecolposcopy. MATERIALS AND METHODS: Women with abnormal Pap results or an abnormal visual examination needing an evaluation by colposcopy were referred to a hospital-based telecolposcopy program...
April 29, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/27049194/the-difficult-primary-total-knee-arthroplasty
#20
Arthur L Malkani, Kirby D Hitt, Sameer Badarudeen, Courtland Lewis, Jeffrey Cherian, Randa Elmallah, Michael A Mont
Primary total knee arthroplasty (TKA) for the treatment of knee arthritis has substantially increased over the past decade. Because of its success, the indications for primary TKA have expanded to include younger patients who are more active, elderly patients who have multiple comorbidities, and patients who have more complex issues, such as posttraumatic arthritis and severe deformity. TKA also has been used to salvage failed unicondylar arthroplasty and osteotomies about the knee. Exposure may be challenging and outcomes may not be as successful in patients with soft-tissue contractures, such as a stiff knee, who undergo TKA...
2016: Instructional Course Lectures
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