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https://www.readbyqxmd.com/read/28628888/an-algorithm-for-filtering-detector-instabilities-in-search-of-novel-non-exponential-decay-and-in-conventional-half-life-determinations
#1
G W Hitt, B Goddard, A A Solodov, D Bridi, A F Isakovic, R El-Khazali
Recent reports of Solar modulation of beta-decay have reignited interest in whether or not radioactive half-lives are constants. A numerical approach for filtering instrumental effects on residuals is developed, using correlations with atmospheric conditions recorded while counting (204)Tl emissions with a Geiger-Müller counter. Half-life oscillations and detection efficiency oscillations can be separated provided their periods are substantially different. A partial uncertainty budget for the (204)Tl half-life shows significant decreases to medium-frequency instabilities correlated with pressure and temperature, which suggests that further development may aid general improvements in half-life determinations...
June 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28548499/polyoxovanadate-alkoxide-clusters-as-a-redox-reservoir-for-iron
#2
Feng Li, Stephanie H Carpenter, Robert F Higgins, Mark G Hitt, William W Brennessel, Maryline G Ferrier, Samantha K Cary, Juan S Lezama-Pacheco, Joshua T Wright, Benjamin W Stein, Matthew P Shores, Michael L Neidig, Stosh A Kozimor, Ellen M Matson
Inspired by the multielectron redox chemistry achieved using conventional organic-based redox-active ligands, we have characterized a series of iron-functionalized polyoxovanadate-alkoxide clusters in which the metal oxide scaffold functions as a three-dimensional, electron-deficient metalloligand. Four heterometallic clusters were prepared through sequential reduction, demonstrating that the metal oxide scaffold is capable of storing up to four electrons. These reduced products were characterized by cyclic voltammetry, IR, electronic absorption, and (1)H NMR spectroscopies...
May 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28527423/task-related-and-person-related-variables-influence-the-effect-of-low-back-pain-on-anticipatory-postural-adjustments
#3
Jesse V Jacobs, Courtney A Lyman, Juvena R Hitt, Sharon M Henry
BACKGROUND: People with low back pain exhibit altered postural coordination that has been suggested as a target for treatment, but heterogeneous presentation has rendered it difficult to identify appropriate candidates and protocols for such treatments. This study evaluated the associations of task-related and person-related factors with the effect of low back pain on anticipatory postural adjustments. METHODS: Thirteen subjects with and 13 without low back pain performed seated, rapid arm flexion in self-initiated and cued conditions...
May 17, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28522258/high-resolution-3%C3%A2-t-mri-of-traumatic-and-degenerative-triangular-fibrocartilage-complex-tfcc-abnormalities-using-palmer-and-outerbridge-classifications
#4
T Nozaki, G Rafijah, L Yang, T Ueno, S Horiuchi, D Hitt, H Yoshioka
AIM: To investigate the usefulness of high-resolution 3 T magnetic resonance imaging (MRI) for the evaluation of traumatic and degenerative triangular fibrocartilage complex (TFCC) abnormalities among three groups: patients presenting with wrist pain who were (a) younger than age 50 years or (b) age 50 or older (PT<50 and PT≥50, respectively), and (c) asymptomatic controls who were younger than age 50 years (AC). MATERIALS AND METHODS: High-resolution 3 T MRI was evaluated retrospectively in 96 patients, including 47 PT<50, 38 PT≥50, and 11 AC...
May 15, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28314810/unusual-case-of-venous-thrombosis
#5
Oliver Jones, Richard Gooding
A young woman developed a line-associated deep vein thrombosis (DVT), which was treated with low molecular weight heparin (dalteparin). 8 days later, the DVT had significantly extended-in spite of therapeutic heparin levels. A diagnosis of heparin-induced thrombocytopenia and thrombosis (HITT) was considered, but the platelet count had not dropped. Nevertheless, a HITT assay was carried out which came back positive, with a repeat assay confirming the result. Dalteparin was stopped and apixaban treatment started, with symptomatic recovery over the following days and weeks...
March 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28301915/emerging-role-of-direct-oral-anticoagulants-in-the-management-of-heparin-induced-thrombocytopenia
#6
Phu Ngoc Tran, Minh-Ha Tran
Heparin-induced thrombocytopenia (HIT) and heparin-induced thrombocytopenia with thrombosis (HITT) are rare but potentially limb- and life-threatening complications of heparin therapy. Continuation of heparin or low-molecular-weight heparin is contraindicated due to platelet activation in the presence of (heparin-dependent) HIT antibodies. Primary treatment options currently include argatroban, fondaparinux, or bivalirudin. However, the parenteral administration routes and interference of argatroban with traditional coagulation markers complicate management...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28292199/high-resolution-mri-of-the-ulnar-and-radial-collateral-ligaments-of-the-wrist
#7
Taiki Nozaki, Wei Der Wu, Yasuhito Kaneko, Gregory Rafijah, Lily Yang, Dave Hitt, Hiroshi Yoshioka
Background Accurate diagnosis of injuries to the collateral ligaments of the wrist is technically challenging on MRI. Purpose To investigate usefulness of high-resolution two-dimensional (2D) and isotropic three-dimensional (3D) magnetic resonance imaging (MRI) for identifying and classifying the morphology of the ulnar and radial collateral ligaments (UCL and RCL) of the wrist. Material and Methods Thirty-seven participants were evaluated using 3T coronal 2D and isotropic 3D images by two radiologists independently...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28289828/is-low-serum-albumin-level-a-significant-predictor-for-the-development-of-heparin-induced-thrombocytopenia-thrombosis
#8
Fahad A S Al-Eidan, J A Al-Gramish, H A Al-Zamil, M A Crowther
The present study investigates the effect of albumin levels in patients who have developed heparin-induced thrombocytopenia (HIT) and heparin-induced thrombocytopenia-thrombosis (HITT). A retrospective observational cohort study was conducted at King Abudlaziz Medical City (KAMC), a university teaching hospital, on patients diagnosed with HIT between June 2013 and December 2014. Clinical and laboratory findings were used to confirm HIT. Albumin levels were reported on admission as baseline and during HIT occurrence...
March 13, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28289079/deletion-of-f4l-ribonucleotide-reductase-in-vaccinia-virus-produces-a-selective-oncolytic-virus-and-promotes-anti-tumor-immunity-with-superior-safety-in-bladder-cancer-models
#9
Kyle G Potts, Chad R Irwin, Nicole A Favis, Desmond B Pink, Krista M Vincent, John D Lewis, Ronald B Moore, Mary M Hitt, David H Evans
Bladder cancer has a recurrence rate of up to 80% and many patients require multiple treatments that often fail, eventually leading to disease progression. In particular, standard of care for high-grade disease, Bacillus Calmette-Guérin (BCG), fails in 30% of patients. We have generated a novel oncolytic vaccinia virus (VACV) by mutating the F4L gene that encodes the virus homolog of the cell-cycle-regulated small subunit of ribonucleotide reductase (RRM2). The F4L-deleted VACVs are highly attenuated in normal tissues, and since cancer cells commonly express elevated RRM2 levels, have tumor-selective replication and cell killing...
May 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28182804/medical-and-economic-burden-of-heparin-induced-thrombocytopenia-a-retrospective-nationwide-inpatient-sample-nis-study
#10
Ranjan Pathak, Vijaya Raj Bhatt, Paras Karmacharya, Madan Raj Aryal, Anthony A Donato
In recent years, US hospitals have switched from use of unfractionated heparin to use of low-molecular-weight heparin, which is associated with lower risk of heparin-induced thrombocytopenia (HIT). In the study reported here, we retrospectively searched the Nationwide Inpatient Sample (NIS) for patients who were at least 18 years old and received a diagnosis of HIT between 2009 and 2011. Our goal was to get an updated perspective on the incidence and economic impact of HIT. We calculated the incidence of HIT overall and in subgroups of patients who underwent cardiac, vascular, or orthopedic surgery...
February 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28177337/free-flap-loss-caused-by-heparin-induced-thrombocytopenia-and-thrombosis-hitt-a-case-report-and-literature-review
#11
E Segna, A R Bolzoni, C Baserga, A Baj
Heparin-induced thrombocytopenia and thrombosis (HITT) represents a dramatic condition that is difficult to diagnose because of nuanced clinical presentation. Therefore, in every case of microvascular thrombosis during heparin-therapy prompt suspicion about HITT is necessary to avoid flap necrosis. We present a case of HITT which, as the 8 other articles reviewed, clearly shows that HITT is difficult to diagnose and complex to manage. Microvascular reconstruction is the first choice in head and neck reconstruction; unfortunately, dramatic outcomes in free flap surgery due to unpredictable thrombotic events are still reported in the English literature...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28053114/feelnc-a-tool-for-long-non-coding-rna-annotation-and-its-application-to-the-dog-transcriptome
#12
Valentin Wucher, Fabrice Legeai, Benoît Hédan, Guillaume Rizk, Lætitia Lagoutte, Tosso Leeb, Vidhya Jagannathan, Edouard Cadieu, Audrey David, Hannes Lohi, Susanna Cirera, Merete Fredholm, Nadine Botherel, Peter A J Leegwater, Céline Le Béguec, Hille Fieten, Jeremy Johnson, Jessica Alföldi, Catherine André, Kerstin Lindblad-Toh, Christophe Hitte, Thomas Derrien
Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify the different classes of RNAs among the plethora of reconstructed transcripts, particularly those that will be translated (mRNAs) from the class of long non-coding RNAs (lncRNAs). Here, we present FEELnc (FlExible Extraction of LncRNAs), an alignment-free program that accurately annotates lncRNAs based on a Random Forest model trained with general features such as multi k-mer frequencies and relaxed open reading frames...
May 5, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28052584/activated-platelet-derived-and-leukocyte-derived-circulating-microparticles-and-the-risk-of-thrombosis-in-heparin-induced-thrombocytopenia-a-role-for-pf4-bearing-microparticles
#13
Elena Campello, Claudia M Radu, Elena Duner, Anna M Lombardi, Luca Spiezia, Raffaele Bendo, Silvia Ferrari, Paolo Simioni, Fabrizio Fabris
BACKGROUND: Though the presence of platelets-derived microparticles (MPs) have previously been described in heparin-induced thrombocytopenia (HIT), the mechanism of thrombosis in HIT remains poorly understood. We aimed to assess the presence and origin of MPs in patients with HIT and their possible contribution to HIT with thrombosis (HITT). METHODS: Forty-five patients with HIT and 45 matched hospitalized patients with not confirmed HIT (HIT-negative) were enrolled...
January 3, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28033318/a-point-mutation-in-a-lincrna-upstream-of-gdnf-is-associated-to-a-canine-insensitivity-to-pain-a-spontaneous-model-for-human-sensory-neuropathies
#14
Jocelyn Plassais, Laetitia Lagoutte, Solenne Correard, Manon Paradis, Eric Guaguère, Benoit Hédan, Alix Pommier, Nadine Botherel, Marie-Christine Cadiergues, Philippe Pilorge, David Silversides, Maud Bizot, Mark Samuels, Carme Arnan, Rory Johnson, Christophe Hitte, Gilles Salbert, Agnès Méreau, Pascale Quignon, Thomas Derrien, Catherine André
Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds are particularly affected by such neuropathies. Clinical signs appear in young puppies and consist of acral analgesia, with or without sudden intense licking, biting and severe self-mutilation of the feet, whereas proprioception, motor abilities and spinal reflexes remain intact. Through a Genome Wide Association Study (GWAS) with 24 affected and 30 unaffected sporting dogs using the Canine HD 170K SNP array (Illumina), we identified a 1...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/28018628/amy2b-copy-number-variation-reveals-starch-diet-adaptations-in-ancient-european-dogs
#15
Morgane Ollivier, Anne Tresset, Fabiola Bastian, Laetitia Lagoutte, Erik Axelsson, Maja-Louise Arendt, Adrian Bălăşescu, Marjan Marshour, Mikhail V Sablin, Laure Salanova, Jean-Denis Vigne, Christophe Hitte, Catherine Hänni
Extant dog and wolf DNA indicates that dog domestication was accompanied by the selection of a series of duplications on the Amy2B gene coding for pancreatic amylase. In this study, we used a palaeogenetic approach to investigate the timing and expansion of the Amy2B gene in the ancient dog populations of Western and Eastern Europe and Southwest Asia. Quantitative polymerase chain reaction was used to estimate the copy numbers of this gene for 13 ancient dog samples, dated to between 15 000 and 4000 years before present (cal...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27989383/dynamic-property-changes-in-stapedial-annular-ligament-associated-with-acute-otitis-media-in-the-chinchilla
#16
Brooke M Hitt, Xuelin Wang, Rong Z Gan
Located at the end of the ossicular chain, the stapedial annular ligament (SAL) serves as a closed yet mobile boundary between the cochlear fluid and stapes footplate. It is unclear how SAL properties change with acute otitis media (AOM). This paper reports the measurements of SAL dynamic properties in chinchilla AOM model using dynamic mechanical analyzer (DMA) and frequency-temperature superposition (FTS) principle. AOM was analyzed in two infection groups: 4 days (4D) and 8 days (8D) post induction. SAL specimens were measured using DMA at three temperatures: 5, 25, and 37°C...
February 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27943167/erratum-to-bioinformatics-pipeline-for-transcriptome-sequencing-analysis
#17
Sarah Djebali, Valentin Wucher, Sylvain Foissac, Christophe Hitte, Erwan Corre, Thomas Derrien
No abstract text is available yet for this article.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27870061/re-annotation-improved-large-scale-assembly-and-establishment-of-a-catalogue-of-noncoding-loci-for-the-genome-of-the-model-brown-alga-ectocarpus
#18
Alexandre Cormier, Komlan Avia, Lieven Sterck, Thomas Derrien, Valentin Wucher, Gwendoline Andres, Misharl Monsoor, Olivier Godfroy, Agnieszka Lipinska, Marie-Mathilde Perrineau, Yves Van De Peer, Christophe Hitte, Erwan Corre, Susana M Coelho, J Mark Cock
The genome of the filamentous brown alga Ectocarpus was the first to be completely sequenced from within the brown algal group and has served as a key reference genome both for this lineage and for the stramenopiles. We present a complete structural and functional reannotation of the Ectocarpus genome. The large-scale assembly of the Ectocarpus genome was significantly improved and genome-wide gene re-annotation using extensive RNA-seq data improved the structure of 11 108 existing protein-coding genes and added 2030 new loci...
April 2017: New Phytologist
https://www.readbyqxmd.com/read/27855238/adrenal-crisis-secondary-to-bilateral-adrenal-haemorrhage-after-hemicolectomy
#19
Anthony Logaraj, Venessa H M Tsang, Shahrir Kabir, Julian C Y Ip
Adrenal haemorrhage is a rare cause of adrenal crisis, which requires rapid diagnosis, prompt initiation of parenteral hydrocortisone and haemodynamic monitoring to avoid hypotensive crises. We herein describe a case of bilateral adrenal haemorrhage after hemicolectomy in a 93-year-old female with high-grade colonic adenocarcinoma. This patient's post-operative recovery was complicated by an acute hypotensive episode, hypoglycaemia and syncope, and subsequent computed tomography (CT) scan of the abdomen revealed bilateral adrenal haemorrhage...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27849484/the-benefits-of-high-intensity-functional-training-fitness-programs-for-military-personnel
#20
Christopher K Haddock, Walker S C Poston, Katie M Heinrich, Sara A Jahnke, Nattinee Jitnarin
INTRODUCTION: High intensity functional training (HIFT) programs are designed to address multiple fitness domains, potentially providing improved physical and mental readiness in a changing operational environment. Programs consistent with HIFT principals such as CrossFit, SEALFIT and the US Marine Corps' High Intensity Tactical Training (HITT) are increasingly popular among military personnel. The goal of HIFT programs is to produce high levels of cardiorespiratory fitness, endurance and strength that exceed those achieved by following current physical activity recommendations...
November 2016: Military Medicine
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