keyword
https://read.qxmd.com/read/38533739/rozanolixizumab-a-new-therapy-in-the-treatment-of-myasthenia-gravis
#1
REVIEW
Emily M Hitt
OBJECTIVE: The aims of this article are to review the clinical aspects of rozanolixizumab, to describe clinical trial results that led to the drug's approval, and to examine the impact on patient care to aid clinical decision making. DATA SOURCES: A PubMed search was conducted using the terms Rystiggo ™, rozanolixizumab , rozanolixizumab therapy , and myasthenia gravis . The most recent prescribing information was also used for information relating to the drug and for identification of pertinent studies...
March 27, 2024: Annals of Pharmacotherapy
https://read.qxmd.com/read/38530844/assessing-transgenerational-trauma-transmission-development-and-psychometric-properties-of-the-historical-intergenerational-trauma-transmission-questionnaire-hitt-q
#2
JOURNAL ARTICLE
Vera Békés, Claire J Starrs
ABSTRACT Objective/Background: Despite increasing attention on transgenerational trauma, currently no comprehensive model and measure exists to be applied on various populations. This study represents the first step in the validation of such a model and a related scale. The Historical Intergenerational Trauma Questionnaire (HITT-Q) assesses family and offspring self-reported vulnerability and resilience, as well as offspring historical moral injury and current levels of insidious trauma. Method: We developed the HITT-Q based on the cross-population model (HITT model; [Starrs, C...
2024: European Journal of Psychotraumatology
https://read.qxmd.com/read/38498459/oncolytic-vaccinia-virus-immunotherapy-antagonizes-image-guided-radiotherapy-in-mouse-mammary-tumor-models
#3
JOURNAL ARTICLE
Brittany A Umer, Ryan S Noyce, Quinten Kieser, Nicole A Favis, Mira M Shenouda, Kim J Rans, Jackie Middleton, Mary M Hitt, David H Evans
Ionizing radiation (IR) and oncolytic viruses are both used to treat cancer, and the effectiveness of both agents depends upon stimulating an immune response against the tumor. In this study we tested whether combining image guided ionizing radiation (IG-IR) with an oncolytic vaccinia virus (VACV) could yield a better therapeutic response than either treatment alone. ΔF4LΔJ2R VACV grew well on irradiated human and mouse breast cancer cells, and the virus can be combined with 4 or 8 Gy of IR to kill cells in an additive or weakly synergistic manner...
2024: PloS One
https://read.qxmd.com/read/38383584/a-phase-iii-randomized-controlled-study-of-safety-and-immunogenicity-of-dtwp-hepb-ipv-hib-vaccine-hexasiil-%C3%A2-in-infants
#4
JOURNAL ARTICLE
Hitt Sharma, Sameer Parekh, Pramod Pujari, Sunil Shewale, Shivani Desai, Anand Kawade, Sanjay Lalwani, M D Ravi, Veena Kamath, Jagannath Mahopatra, Ganesh Kulkarni, Deepak Tayade, Padmasani Venkat Ramanan, Kheya Ghosh Uttam, Lalit Rawal, Avinash Gawande, N Ravi Kumar, Nishikant Tiple, Jayant Vagha, Pareshkumar Thakkar, Prashant Khandgave, Bhaskar Jedhe Deshmukh, Anurag Agarwal, Vikas Dogar, Manish Gautam, K S Jaganathan, Rakesh Kumar, Inderjit Sharma, Sunil Gairola
A fully liquid hexavalent containing Diphtheria (D), Tetanus (T) toxoids, whole cell Pertussis (wP), Hepatitis B (Hep B), type 1, 2, 3 of inactivated poliovirus (IPV) and Haemophilus influenzae type b (Hib) conjugate vaccine (DTwP-HepB-IPV-Hib vaccine, HEXASIIL® ) was tested for lot-to-lot consistency and non-inferiority against licensed DTwP-HepB-Hib + IPV in an open label, randomized Phase II/III study. In Phase III part, healthy infants received DTwP-HepB-IPV-Hib or DTwP-HepB-Hib + IPV vaccines at 6, 10 and 14 weeks of age...
February 22, 2024: NPJ Vaccines
https://read.qxmd.com/read/38349857/toward-controlled-synthesis-of-2d-crystals-by-cvd-learning-from-the-real-time-crystal-morphology-evolutions
#5
JOURNAL ARTICLE
Jing Zhang, Tianshu Zhai, Faizal Arifurrahman, Yuguo Wang, Andrew Hitt, Zelai He, Qing Ai, Yifeng Liu, Chen-Yang Lin, Yifan Zhu, Ming Tang, Jun Lou
The rich morphology of 2D materials grown through chemical vapor deposition (CVD), is a distinctive feature. However, understanding the complex growth of 2D crystals under practical CVD conditions remains a challenge due to various intertwined factors. Real-time monitoring is crucial to providing essential data and enabling the use of advanced tools like machine learning for unraveling these complexities. In this study, we present a custom-built miniaturized CVD system capable of observing and recording 2D MoS2 crystal growth in real time...
February 13, 2024: Nano Letters
https://read.qxmd.com/read/38346339/a-collaborative-simulation-navigating-care-and-advocacy-for-diverse-patients-in-crisis
#6
JOURNAL ARTICLE
Amanda R Hitt, Lisa Harrington, Amanda Hunt, Rachel Winston, Ashton Glover
BACKGROUND: Collaboration and cultural competence are essential to nursing practice. Simulation-based training allows students to explore sensitive topics safely while surveying their own biases. METHOD: Faculty created a collaborative simulation involving baccalaureate nursing students based on a transgender adolescent with suicidal ideations and a controlling parent. RESULTS: Three themes emerged during debriefings: empathy, communication, and safety...
February 14, 2024: Journal of Nursing Education
https://read.qxmd.com/read/38250744/the-association-of-self-perceived-changes-due-to-covid-19-with-mental-and-physical-health-among-adult-primary-care-patients-with-multiple-chronic-conditions-a-us-based-longitudinal-study
#7
JOURNAL ARTICLE
Levi N Bonnell, Jessica Clifton, Lisa W Natkin, Juvena R Hitt, Benjamin Littenberg
INTRODUCTION: This study explores the association between self-perceived personal and community changes due to COVID-19 and health among vulnerable primary care patients experiencing multiple chronic conditions. METHODS: Between September 2017 and February 2021, we obtained data from 2,426 primary care patients managing multiple chronic conditions from across the United States. We assessed the relationship between self-perceived personal and community changes due to COVID-19 and change in health measured by the PROMIS-29 mental and physical health summary scores, GAD-7 (anxiety), andPHQ-9 (depression), and DASI (functional capacity) adjusting for relevant demographic, neighborhood characteristics, and county covariates...
2024: J Multimorb Comorb
https://read.qxmd.com/read/38199581/is-high-intensity-interval-training-more-effective-than-moderate-continuous-training-in-rehabilitation-of-multiple-sclerosis-a-comprehensive-systematic-review-and-meta-analysis
#8
REVIEW
Hussein Youssef, Mine Nur Gönül, Mohamed Gomaa Sobeeh, Kardelen Akar, Peter Feys, Koen Cuypers, Atay Vural
OBJECTIVES: The present study aimed to conduct meta-analysis to determine whether the high intensity interval training (HIIT) protocol is more beneficial in improving outcome measures compared to Moderate continuous training (MCT) in people with multiple sclerosis (pwMS). In addition, to systematically review the exercise protocols differences. DATA SOURCES: A search strategy, locating HIIT in pwMS, was executed in six databases, PubMed, EMBASE, Web of Science, Central Cochrane, Pedro, and Ovid MEDLine...
January 8, 2024: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/38198513/sexual-violence-and-social-media-discourse-exploring-campus-climate-through-the-lens-of-twitter
#9
JOURNAL ARTICLE
Hilary Ashton Glover, Amanda Hitt, Nikki Davenport, Victoria Casson, Tabitha Blasingame
BACKGROUND: Sexual violence is prevalent on college campuses, yet formal disclosure and open dialogue are often muffled. Social media has become a powerful platform for survivors and presents an opportunity for researchers to explore social discourse surrounding sexual violence on campuses. Healthcare providers must be knowledgeable of campus climate surrounding sexual violence to provide patient-centered, trauma-informed care and mitigate the detrimental, long-term effects experienced by survivors...
January 10, 2024: Journal of Forensic Nursing
https://read.qxmd.com/read/38159428/physiological-and-psychological-outcomes-of-high-intensity-interval-training-in-patients-with-heart-failure-compared-to-moderate-continuous-training-and-usual-care-a-systematic-review-with-meta-analysis
#10
JOURNAL ARTICLE
Kara Callum, Paul Swinton, Trish Gorely, Daniel Crabtree, Stephen Leslie
BACKGROUND: An important component of secondary prevention of CVD (including HF) is comprehensive cardiac rehab, including exercise. Novel, individualised approaches are needed to increase uptake and adherence to exercise programmes, one area offering potential is HIIT. HIIT has been shown to be both safe and effective for improving cardiovascular fitness in both coronary artery disease and HF patients. OBJECTIVES: To provide a current and up to date evaluation of the physiological and psychological outcomes of HIIT in patients with HF compared to MCT and UC...
December 29, 2023: Heart & Lung: the Journal of Critical Care
https://read.qxmd.com/read/38153027/successful-treatment-with-the-oral-factor-xa-inhibitor-edoxaban-in-heparin-induced-thrombocytopenia-with-thrombosis
#11
JOURNAL ARTICLE
Mateo Porres-Aguilar, Carolina Najera, Adriana C Mares, Ilham Benzidia, Swathi Prakash, Benjamin Crichi
Heparin-induced thrombocytopenia with thrombosis (HITT) is a rare immune reaction to the drug heparin that causes increased blood clotting, putting patients at risk for arterial and venous thromboembolism which can have severe consequences. We present a case of HITT successfully treated with the direct oral anticoagulant (DOAC), edoxaban. A 56-year-old man had surgery to remove a colorectal mass. After discharge, he developed chest discomfort, shortness of breath, and low oxygen levels and was diagnosed with a right-sided lobar pulmonary embolism...
December 28, 2023: Angiology
https://read.qxmd.com/read/38123608/psychological-distress-and-voting-behaviour-in-nine-countries-of-the-former-soviet-union
#12
JOURNAL ARTICLE
Andrew Stickley, Tomiki Sumiyoshi, Naoki Kondo, Mall Leinsalu, Yosuke Inoue, Vladislav Ruchkin, Jae Il Shin, Martin McKee
Poorer mental health is linked to a lower likelihood of voting in elections. However, little is known about this association in non-Western settings. This study examined the association between psychological distress and voting in nine countries of the former Soviet Union (FSU). Data were analysed from 18,000 respondents aged ≥ 18 in Armenia, Azerbaijan, Belarus, Georgia, Moldova, Kazakhstan, Kyrgyzstan, Russia and Ukraine collected during the Health in Times of Transition (HITT) survey in 2010/11...
December 19, 2023: Scientific Reports
https://read.qxmd.com/read/38072056/tau-seeding-without-tauopathy
#13
JOURNAL ARTICLE
Michael S LaCroix, Efrosini Artikis, Brian D Hitt, Joshua D Beaver, Sandi-Jo Estill-Terpack, Kelly Gleason, Carol A Tamminga, Bret M Evers, Charles L White, Byron Caughey, Marc I Diamond
Neurodegenerative tauopathies such as Alzheimer's disease (AD) are caused by brain accumulation of tau assemblies. Evidence suggests tau functions as a prion, and cells and animals efficiently propagate unique, transmissible tau pathology. This suggests a dedicated cellular replication machinery, potentially with a normal physiologic function for tau seeds. Consequently, we hypothesized that healthy control brains would have seeding activity. We have recently developed a novel monoclonal antibody (MD3.1) specific for tau seeds...
December 8, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/38033400/improved-oncolytic-activity-of-a-reovirus-mutant-that-displays-enhanced-virus-spread-due-to-reduced-cell-attachment
#14
JOURNAL ARTICLE
Francisca Cristi, Maiah Walters, Nashae Narayan, Kate Agopsowicz, Mary M Hitt, Maya Shmulevitz
Wild-type reovirus serotype 3 Dearing (T3wt), a non-pathogenic intestinal virus, has shown promise as a cancer therapy in clinical trials, but it would benefit from an increased potency. Given that T3wt is naturally adapted to the intestinal environment (rather than tumors), we genetically modified reovirus to improve its infectivity in cancer cells. Various reovirus mutants were created, and their oncolytic potency was evaluated in vitro using plaque size as a measure of virus fitness in cancer cells...
December 19, 2023: Molecular Therapy Oncolytics
https://read.qxmd.com/read/38030893/covid-19-vaccine-induced-immune-thrombotic-thrombocytopenia-pathophysiology-and-diagnosis
#15
REVIEW
Akbar Dorgalaleh, Ashkan Shabannezhad, Saeed Hassani
Coronavirus disease-19 (COVID-19) vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but serious clinical condition with high mortality rate in apparently healthy individuals without noticeable risk factors. VITT typically arises due to the administration of vaccines that possess recombinant adenoviral vectors, including ChAdOx1 nCov-19 (AstraZeneca) and Ad26 COV2.S (Johnson & Johnson/Janssen). Thrombosis frequently occurs at atypical sites, such as the cerebral or splanchnic circulations, in this particular pathological state...
November 30, 2023: Annals of Hematology
https://read.qxmd.com/read/38012036/a-cluster-randomized-trial-of-primary-care-practice-redesign-to-integrate-behavioral-health-for-those-who-need-it-most-patients-with-multiple-chronic-conditions
#16
JOURNAL ARTICLE
Benjamin Littenberg, Jessica Clifton, Abigail M Crocker, Laura-Mae Baldwin, Levi N Bonnell, Ryan E Breshears, Peter Callas, Prama Chakravarti, Kelly Clark/Keefe, Deborah J Cohen, Frank V deGruy, Lauren Eidt-Pearson, William Elder, Chester Fox, Sylvie Frisbie, Katie Hekman, Juvena Hitt, Jennifer Jewiss, David C Kaelber, Kairn Stetler Kelley, Rodger Kessler, Jennifer B O'Rourke-Lavoie, George S Leibowitz, C R Macchi, Matthew P Martin, Mark McGovern, Brenda Mollis, Daniel Mullin, Zsolt Nagykaldi, Lisa W Natkin, Wilson Pace, Richard G Pinckney, Douglas Pomeroy, Paula Reynolds, Gail L Rose, Sarah Hudson Scholle, William J Sieber, Jeni Soucie, Terry Stancin, Kurt C Stange, Kari A Stephens, Kathryn Teng, Elizabeth Needham Waddell, Constance van Eeghen
PURPOSE: Patient outcomes can improve when primary care and behavioral health providers use a collaborative system of care, but integrating these services is difficult. We tested the effectiveness of a practice intervention for improving patient outcomes by enhancing integrated behavioral health (IBH) activities. METHODS: We conducted a pragmatic, cluster randomized controlled trial. The intervention combined practice redesign, quality improvement coaching, provider and staff education, and collaborative learning...
2023: Annals of Family Medicine
https://read.qxmd.com/read/38010777/mathematical-modeling-predicts-pathways-to-successful-implementation-of-combination-trail-producing-oncolytic-virus-and-pac-1-to-treat-granulosa-cell-tumors-of-the-ovary
#17
JOURNAL ARTICLE
Justin Le Sauteur-Robitaille, Powel Crosley, Mary Hitt, Adrianne L Jenner, Morgan Craig
The development of new cancer therapies requires multiple rounds of validation from in vitro and in vivo experiments before they can be considered for clinical trials. Mathematical models assist in this preclinical phase by combining experimental data with human parameters to provide guidance about potential therapeutic regimens to bring forward into trials. However, granulosa cell tumors of the ovary lack a relevant mouse model, complexifying preclinical drug development for this rare tumor. To bridge this gap, we established a mathematical model as a framework to explore the potential of using a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-producing oncolytic vaccinia virus in combination with the chemotherapeutic agent first procaspase activating compound (PAC-1)...
December 31, 2023: Cancer Biology & Therapy
https://read.qxmd.com/read/38009635/survey-on-the-continued-impact-of-covid-19-on-immunocompromised-patients-in-rheumatology
#18
JOURNAL ARTICLE
Bonita Libman, Tessalyn Morrison, Laura Haines, Juvena R Hitt, Amanda G Kennedy
No abstract text is available yet for this article.
November 27, 2023: Musculoskeletal Care
https://read.qxmd.com/read/37987546/spatial-asynchrony-and-cross-scale-climate-interactions-in-populations-of-a-coldwater-stream-fish
#19
JOURNAL ARTICLE
George P Valentine, Xinyi Lu, Evan S Childress, C Andrew Dolloff, Nathaniel P Hitt, Matthew A Kulp, Benjamin H Letcher, Kasey C Pregler, Jacob M Rash, Mevin B Hooten, Yoichiro Kanno
Climate change affects populations over broad geographic ranges due to spatially autocorrelated abiotic conditions known as the Moran effect. However, populations do not always respond to broad-scale environmental changes synchronously across a landscape. We combined multiple datasets for a retrospective analysis of time-series count data (5-28 annual samples per segment) at 144 stream segments dispersed over nearly 1,000 linear kilometers of range to characterize the population structure and scale of spatial synchrony across the southern native range of a coldwater stream fish (brook trout, Salvelinus fontinalis), which is sensitive to stream temperature and flow variations...
November 21, 2023: Global Change Biology
https://read.qxmd.com/read/37980622/treating-heparin-induced-thrombocytopenia-in-patients-undergoing-heartmate-3-left-ventricular-assist-device-implantation
#20
JOURNAL ARTICLE
Jonathan Eisenberger, Shmuel Somer, Eilon Ram, Eyal Nachum, Jonathan Frogal, Shany Levin, Jacob Lavee, Leonid Sternik, Jeffrey Morgan
BACKGROUND: Unfractionated heparin is the preferred anticoagulant used during open heart surgeries, including left ventricular assist device (LVAD) implantation. In cases in which patients are heparin-induced thrombocytopenia positive (HIT+), the accepted practice has been to substitute heparin with bivalirudin. This practice may be associated with significant bleeding and adverse outcomes. OBJECTIVES: To review our experience with HIT+ patients who were heparin-induced thrombocytopenia with thrombosis negative (HITT-) and who underwent HeartMate 3 LVAD implantation using heparin intraoperatively rather than bivalirudin...
November 2023: Israel Medical Association Journal: IMAJ
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