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Isolation and characterization of compounds

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https://www.readbyqxmd.com/read/28101124/reduced-up-regulation-of-the-nitric-oxide-pathway-and-impaired-endothelial-and-smooth-muscle-functions-in-the-female-type-2-diabetic-goto-kakizaki-rat-heart
#1
Martine Desrois, Carole Lan, Jamileh Movassat, Monique Bernard
BACKGROUND: Type 2 diabetes is associated with greater relative risk of cardiovascular diseases in women than in men, which is not well understood. Consequently, we have investigated if male and female displayed differences in cardiac function, energy metabolism, and endothelial function which could contribute to increased cardiovascular complications in type 2 diabetic female. METHODS: Male and female Control and type 2 diabetic Goto-Kakizaki (GK) isolated rat hearts were perfused during 28 min with a physiological buffer before freeze-clamping for biochemical assays...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28100224/radical-scavenging-activities-of-lagerstroemia-speciosa-l-pers-petal-extracts-and-its-hepato-protection-in-ccl4-intoxicated-mice
#2
Bipransh Kumar Tiwary, Somit Dutta, Priyankar Dey, Mossaraf Hossain, Anoop Kumar, Sony Bihani, Ashis Kumar Nanda, Tapas Kumar Chaudhuri, Ranadhir Chakraborty
BACKGROUND: Lagerstroemia speciosa (L.) Pers. has medicinal importance. Bioactive phytochemicals isolated from different parts of L. speciosa, have revealed hypoglycemic, antibacterial, anti-inflammatory, antioxidant and hepato protective properties. Despite one report from Philippines detailing the use of L. speciosa as curative for fever and as well as diuretic, there is no experimental evidence about the hepatoprotective activity of the flower extracts. METHODS: Several spectroscopic methods, including GC-MS, were used to characterize phytochemicals present in the petal extract of L...
January 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28098763/new-abietane-and-kaurane-type-diterpenoids-from-the-stems-of-tripterygium-regelii
#3
Dongsheng Fan, Shuangyan Zhou, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Ming-Rong Yang, Zhi-Hong Jiang, Li-Ping Bai
Eleven new abietane type (1‒11), and one new kaurane (12), diterpenes, together with eleven known compounds (13-23), were isolated and identified from the stems of Tripterygium regelii, which has been used as a traditional folk Chinese medicine for the treatment of rheumatoid arthritis in China. The structures of new compounds were characterized by means of the interpretation of high-resolution electrospray ionization mass spectrometry (HRESIMS), extensive nuclear magnetic resonance (NMR) spectroscopic data and comparisons of their experimental CD spectra with calculated electronic circular dichroism (ECD) spectra...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098355/a-comparative-study-on-composition-and-antioxidant-activities-of-supercritical-carbon-dioxide-hexane-and-ethanol-extracts-from-blackberry-rubus-fruticosus-growing-in-poland
#4
Anna Wajs-Bonikowska, Agnieszka Stobiecka, Radosław Bonikowski, Agnieszka Krajewska, Magdalena Sikora, Józef Kula
BACKGROUND: Large quantities of blackberry seeds are produced as a pomace during the processing of juice and jam production - this by-product is a very interesting raw material both for oil manufacturing and as a source of bioactive compounds. In this work the composition, yield and antioxidant activity of three types of Rubus fructicosus pomace extracts isolated by liquid-extraction using solvents of different polarity, as well with supercritical CO2 fluid extraction have been compared...
January 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28098290/in-situ-ligand-exchange-mediated-0d-1d-transformation-of-a-polyoxovanadate
#5
M Wendt, P Polzin, J van Leusen, C Näther, P Kögerler, W Bensch
The antimonato-polyoxovanadate {Ni(II)(en)3}3[VSbO42(H2O)]·ca.15H2O was utilized as a synthon for the solvothermal in situ generation of the new compound {Ni(II)(phen)3}2[{Ni(II)(en)2}VSbO42(H2O)]·19H2O, a rearrangement induced by ligand metathesis. While in the precursor structure cations and anions are isolated, the solid-state structure of the product is characterized by 1D chains consisting of alternating [V15Sb6O42(H2O)](6-) cluster shells and [Ni(en)2](2+) units covalently linked to neighboring clusters via terminal oxygen atoms...
January 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28098172/structural-diversity-of-anti-pancreatic-cancer-capsimycins-identified-in-mangrove-derived-streptomyces-xiamenensis-318-and-post-modification-via-a-novel-cytochrome-p450-monooxygenase
#6
He-Lin Yu, Shu-Heng Jiang, Xu-Liang Bu, Jia-Hua Wang, Jing-Yi Weng, Xiao-Mei Yang, Kun-Yan He, Zhi-Gang Zhang, Ping Ao, Jun Xu, Min-Juan Xu
Polycyclic tetramate macrolactams (PTMs) were identified as distinct secondary metabolites of the mangrove-derived Streptomyces xiamenensis 318. Together with three known compounds-ikarugamycin (1), capsimycin (2) and capsimycin B (3)-two new compounds, capsimycin C (4) with trans-diols and capsimycin D (5) with trans-configurations at C-13/C-14, have been identified. The absolute configurations of the tert/tert-diols moiety was determined in 4 by NMR spectroscopic analysis, CD spectral comparisons and semi-synthetic method...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28095778/the-pangenome-of-antarctic-pseudoalteromonas-bacteria-evolutionary-and-functional-insights
#7
Emanuele Bosi, Marco Fondi, Valerio Orlandini, Elena Perrin, Isabel Maida, Donatella de Pascale, Maria Luisa Tutino, Ermenegilda Parrilli, Angelina Lo Giudice, Alain Filloux, Renato Fani
BACKGROUND: Pseudoalteromonas is a genus of ubiquitous marine bacteria used as model organisms to study the biological mechanisms involved in the adaptation to cold conditions. A remarkable feature shared by these bacteria is their ability to produce secondary metabolites with a strong antimicrobial and antitumor activity. Despite their biotechnological relevance, representatives of this genus are still lacking (with few exceptions) an extensive genomic characterization, including features involved in the evolution of secondary metabolites production...
January 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28094932/series-d-f-heteronuclear-metal-organic-frameworks-color-tunability-and-luminescent-probe-with-switchable-properties
#8
Xun Feng, Yuquan Feng, Nan Guo, Yiling Sun, Tian Zhang, Lufang Ma, Liya Wang
A series of five unique d-f heteronuclear luminescent metal-organic frameworks (MOFs) in an entangled polyrotaxane array and the light-harvesting block homonuclear zinc compound have been isolated successfully and characterized. The series of isostructural polymers feature 3,4-connected (4.8(2))(4.8(3).9(2))(6.8.9)2(6.9(2))(8(3)) topology and high stability, exhibiting diverse void spaces. By taking advantage of the isostructural MOFs 2 and 3, the intensities of red and green emissions can be modulated by adjusting the ratios of Eu(III) and Tb(III) ions correspondingly, and white-light emission can be generated by a combination of different doped Tb(III) and Eu(III) concentrations...
January 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28094467/chemical-composition-and-biological-activities-of-the-essential-oil-from-leaves-and-flowers-of-pulicaria-incisa-sub-candolleana-growing-in-egypt
#9
Esraa A Shahat, Riham O Bakr, Omayma A Eldahshan, Nahla A Ayoub
The composition of the essential oil isolated from leaves and flowers of Pulicaria incisa sub. candolleana E.Gamal-Eldin was analysed by GC and GC-MS. Forty-nine and sixty-eight compounds were identified from the oils of the leaves and flowers accounting for 86.69% and 84.29%, respectively of the total detected constituents. Both leaves and flowers oils were characterized by the high content of each carvotanacetone with 66.01%, 50.87% and chrysanthenone 13.26%, 24.3% respectively. The cytotoxic activity of both essential oils was evaluated against hepatocellular carcinoma cell line HEPG-2, using MTT assay and vinblastine as a reference drug...
January 17, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28092137/isolation-and-characterization-of-rhizobium-sp-strain-ys-1r-that-degrades-lignin-in-plant-biomass
#10
Colin A Jackson, Matthew B Couger, Madhu Prabhakaran, Karthikeyan D Ramachandriya, Patricia Canaan, Babu Z Fathepure
AIMS: The aim of this work was to isolate novel lignin degrading organisms. METHODS AND RESULTS: Several pure cultures of bacteria that degrade lignin were isolated from bacterial consortia developed from decaying biomass. Among the isolates, Rhizobium sp. strain YS-1r (closest relative of Rhizobium petrolearium Strain SL-1) was explored for its lignin degrading ability. Microcosm studies showed that strain YS-1r was able to degrade a variety of lignin monomers, dimers, and also native lignin in switchgrass and alfalfa...
January 16, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28090278/isolation-and-identification-of-phyllospheric-bacteria-possessing-antimicrobial-activity-from-astragalus-obtusifolius-prosopis-juliflora-xanthium-strumarium-and-hippocrepis-unisiliqousa
#11
Zohreh Mazinani, Marzieh Zamani, Soroush Sardari
BACKGROUND: The widespread utilization of antimicrobial compounds has caused emergence of resistant microorganisms in the world. Hence, the research to probe the products with antimicrobial features has led to finding natural habitats and discovering new pharmaceutical products. METHODS: In this study, an attempt was made to explore the niche of novel habitat to isolate pyllospheric bacteria from the above ground parts (stems and leaves) of Astragalus obtusifolius, Prosopis juliflora, Xanthium strumarium, and Hippocrepis unisiliqousa to evaluate their antimicrobial features...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28089737/browplasminin-a-condensed-tannin-with-anti-plasmin-activity-isolated-from-an-aqueous-extract-of-brownea-grandiceps-jacq-flowers
#12
Betzabeth Pereira, Josmary Brazón, Mónica Rincón, Eva Vonasek
ETHNOPHARMACOLOGICAL RELEVANCE: Following Venezuelan traditional medicine, females with heavy menstrual blood loss (menorrhagia) drink Brownea grandiceps Jacq. flowers (BG) decoctions to reduce the bleeding. In a previous study, we demonstrated that BG aqueous extract (E) possesses a potent anti-fibrinolytic activity capable of inhibiting plasmin, the main serine-protease that degrades fibrin. It is widely known that plasmin inhibitors are often used as anti-fibrinolytics to reduce bleeding during surgeries with high risk of blood loss such as cardiac, liver, vascular, tooth extraction and large orthopedic procedures, as well as for menorrhagia treatments...
January 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28089734/broadening-the-phenotype-of-dfnb28-mutations-in-triobp-are-associated-with-moderate-stable-hereditary-hearing-impairment
#13
Mieke Wesdorp, Jiddeke M van de Kamp, Erik F Hensen, Margit Schraders, Jaap Oostrik, Helger G Yntema, Ilse Feenstra, Ronald J C Admiraal, Henricus P M Kunst, Mustafa Tekin, Moien Kanaan, Hannie Kremer, Ronald J E Pennings
DFNB28 is characterized by prelingual, severe to profound sensorineural hearing impairment (HI). It is associated with mutations in exon 6 and 7 of TRIOBP and has not been reported in the European population. Here, we describe two isolated cases of Dutch origin with congenital, moderate HI and compound heterozygous mutations in TRIOBP. Three of the mutations are novel, one nonsense mutation (c.5014G>T (p.Gly1672*)) and two frameshift mutations (c.2653del (p.Arg885Alafs*120) and c.3460_3461del (p.Leu1154Alafs*29))...
January 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28081493/optical-and-vibrational-properties-of-phosphorylcholine-based-contact-lenses-experimental-and-theoretical-investigations
#14
Katarzyna Filipecka, Rafał Miedziński, Maciej Sitarz, Jacek Filipecki, Małgorzata Makowska-Janusik
The Raman, MIR and UV-vis spectroscopy have been used to characterize Omafilcon A material constructing the one of the Proclear family contact lenses. The Omafilcon A is hydrogel material composed of 2-hydroxyethyl methacrylate (HEMA) and 2-methacryloyloxyethyl phosphorylcholine (PC) polymers crosslinked with ethyleneglycol dimethacrylate (EGDMA). Vibrational and electronic properties of the Omafilcon A material were also investigated by quantum chemical calculations. Experimentally obtained Raman, MIR and optical spectra were compared to the theoretical ones calculated applying RHF and DFT methodology...
January 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28081457/surface-active-ionic-liquids-in-catalysis-impact-of-structure-and-concentration-on-the-aerobic-oxidation-of-octanol-in-water
#15
Alice Cognigni, Sebastian Kampichler, Katharina Bica
We present design and synthesis of surface-active ionic liquids for the application in micellar catalysis. A series of 1-methyl-3-dodecylimidazolium based ionic liquids with variable core structures including dicationic and zwitterionic ones was synthesized and characterized. These surface-active ionic liquids where applied in the aerobic oxidation of aliphatic alcohols to carbonyl compounds. A strong dependence on the ionic liquid concentration and structure was identified, which is in accordance with the concepts of micellar catalysis...
December 29, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28074223/characterization-and-mechanism-of-anti-aeromonas-salmonicida-activity-of-a-marine-probiotic-strain-bacillus-velezensis-v4
#16
Xi-Yan Gao, Ying Liu, Li-Li Miao, Er-Wei Li, Guo-Xiang Sun, Ying Liu, Zhi-Pei Liu
The bacterium Aeromonas salmonicida is the causative agent of furunculosis, a systemic, ubiquitous disease of fish in the salmon family, characterized by high mortality and morbidity. Probiotics are a promising approach for prevention of furunculosis in aquaculture. A bacterial strain with anti-A. salmonicida properties, Bacillus velezensis V4, was isolated and the mechanisms underlying these properties were investigated. Anti-A. salmonicida compounds present in cell-free supernatant of V4 were purified and structurally identified as members of the iturin, macrolactin, and difficidin groups...
January 10, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28073550/growth-and-bioactive-secondary-metabolites-of-arctic-protoceratium-reticulatum-dinophyceae
#17
Manuel Sala-Pérez, Tilman J Alpermann, Bernd Krock, Urban Tillmann
Harmful algal blooms are mainly caused by marine dinoflagellates and are known to produce potent toxins that may affect the ecosystem, human activities and health. Such events have increased in frequency and intensity worldwide in the past decades. Numerous processes involved in Global Change are amplified in the Arctic, but little is known about species specific responses of arctic dinoflagellates. The aim of this work was to perform an exhaustive morphological, phylogenetical and toxinological characterization of Greenland Protoceratium reticulatum and, in addition, to test the effect of temperature on growth and production of bioactive secondary metabolites...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28069265/8-hydroxyirilone-5-methyl-ether-and-8-hydroxyirilone-new-antioxidant-and-%C3%AE-amylase-inhibitors-isoflavonoids-from-iris-germanica-rhizomes
#18
Sabrin R M Ibrahim, Gamal A Mohamed, Mohamed F Zayed, Samir A Ross
Iris species are well recognized as wealthy sources of isoflavonoids. In the present study, phytochemical investigation of the rhizomes of Iris germanica (Iridaceae) procure the isolation of two new isoflavonoids namely, 8-hydroxyirilone 5-methyl ether (2) and 8-hydroxyirilone (3), along with eight known isoflavonoids: irilone 4'-methyl ether (1), irilone (4), irisolidone (5), irigenin S (6), irigenin (7), irilone 4'-O-β-d-glucopyranoside (8), iridin S (9), and iridin (10). The isolated flavonoids were structurally characterized with the assist of comprehensive spectroscopic analyses (UV, IR, 1D and 2D NMR, and HRMS) and comparing with the published data...
December 30, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28068637/assembling-of-multifunctional-latex-based-hybrid-nanocarriers-from-calotropis-gigantea-for-sustained-doxorubicin-dox-releases
#19
Periyakaruppan Pradeepkumar, Dharman Govindaraj, Murugaraj Jeyaraj, Murugan A Munusamy, Mariappan Rajan
Natural rubber Latex (Lax) is a colloidal dispersion of polymer particles in liquid and shows good biodegradable, biocompatibility, and non-toxicity. Natural polymers are the most important materials used in food packaging, micro/nano-drug delivery, tissue engineering, agriculture, and coating. In the present study, natural compounds extracted from plant Lax were designed to function as drug carriers using various surfactants via emulation and solvent evaporation method. Calotropis gigantea belongs to the family Apocynaceae and has received considerable attention in modern medicine, ayurvedeic, siddha, and traditional medicine...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28067831/trichophycin-a-a-cytotoxic-linear-polyketide-isolated-from-a-trichodesmium-thiebautii-bloom
#20
Matthew J Bertin, Paul G Wahome, Paul V Zimba, Haiyin He, Peter D R Moeller
In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was completed using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS). Trichophycin A was moderately toxic against the murine neuroblastoma cell line Neuro-2A (EC50: 6...
January 6, 2017: Marine Drugs
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