Read by QxMD icon Read

Isolation and characterization of compounds

Hélène Esselin, Félix Tomi, Ange Bighelli, Sylvain Sutour
The chemical investigation of an ethyl acetate extract (EtOAc) obtained from Laurencia obtusa , collected in Corsica, allowed for the identification of three new compounds ( 1 , 2 , and 4 ) and six known compounds. Compounds 1 to 4 were isolated and fully characterized by a detailed spectroscopic analysis. Compounds 1 and 2 are two C15 -acetogenins sharing the same ring system: a tetrahydropyran linked by a methylene to a tetrahydrofuran ring. Compound 1 exhibits a bromoallene unit whereas compound 2 possesses an uncommon α-bromo-α,β-unsaturated aldehyde terminal unit...
March 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Peter Kämpfer, Hans-Jürgen Busse, Stefanie P Glaeser
A yellow-pigmented, Gram-stain-negative, rod-shaped, non-spore-forming bacterium (strain KSS165-70T ) was isolated from a coolant lubricant emulsion. The 16S rRNA gene sequence analysis of strain KSS165-70T showed high sequence similarity to the type strains of Novosphingobium subterraneum (98.1 %), Novosphingobium lentum (97.9 %) and Novosphingobium taihuense (97.8 %). Sequence similarities to type strains of all other Novosphingobium species were below 97.5 %. Ubiquinone Q-10 was detected as the major respiratory quinone...
March 21, 2018: International Journal of Systematic and Evolutionary Microbiology
Igor L Fedushkin, Anton N Lukoyanov, Evgeny V Baranov
The reduction of 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene (dpp-Bian) with an excess of La metal in the presence of iodine (dpp-Bian/I2 = 2/1) in tetrahydrofuran (thf) or dimethoxyethane (dme) affords lanthanum(III) complexes of dpp-Bian dianion: deep blue [(dpp-Bian)2- LaI(thf)2 ]2 (1, 84%) was isolated by crystallization of the product from hexane, while deep green [(dpp-Bian)LaI(dme)2 ] (2, 93%) precipitated from the reaction mixture in the course of its synthesis. A treatment of complex 1 with 0...
March 21, 2018: Inorganic Chemistry
Ali Maleki, Jamal Rahimi, Oleg M Demchuk, Agnieszka Z Wilczewska, Radomir Jasiński
A green approach for the one-pot four-component sonochemical synthesis of 5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylic esters from the reaction of 2-cyano-guanidine, sodium azide, various aromatic aldehydes and methyl or ethyl acetoacetate in the presence of a catalytic amount of Fe2 O3 @SiO2 -(CH2 )3 NHC(O)(CH2 )2 PPh2 as a new hybrid organic-inorganic core-shell nanomagnetic catalyst is described. This is the first design, preparation, characterization and application of the present nanomaterial and also the first ultrasound irradiated synthesis of the biologically and pharmaceutically important heterocyclic compounds in water as a green solvent...
May 2018: Ultrasonics Sonochemistry
Zheng Cui, Xiachang Wang, Stefan Koppermann, Jon S Thorson, Christian Ducho, Steven G Van Lanen
Muraymycins are nucleoside antibiotics isolated from Streptomyces sp. NRRL 30471 and several mutant strains thereof that were generated by random, chemical mutagenesis. Reinvestigation of two mutant strains using new media conditions led to the isolation of three new muraymycin congeners, named B8, B9, and C6 (1-3), as well as a known muraymycin, C1. Structures of the compounds were elucidated by HRMS and 1D and 2D NMR spectroscopic analyses. Complete 2D NMR assignments for the known muraymycin C1 are also provided for the first time...
March 19, 2018: Journal of Natural Products
Valeria Prigione, Bruno Trocini, Federica Spina, Anna Poli, Davide Romanisio, Samuele Giovando, Giovanna Cristina Varese
Tannins are a complex family of polyphenolic compounds, widely distributed in the plant kingdom where they act as growth inhibitors towards many microorganisms including bacteria, yeasts, and fungi. Tannins are one of the major components of tannery wastewaters and may cause serious environmental pollution. In the present study, four different tannins (the hydrolysable chestnut ellagitannin and tara gallotannin and the condensed quebracho and wattle tannins) were characterized from a mycological point of view with the aim of selecting fungal strains capable of growing in the presence of high tannin concentration and thus potentially useful in industrial biotransformations of these compounds or in the bioremediation of tannery wastewaters...
March 18, 2018: Applied Microbiology and Biotechnology
Juan Román, Antonio Castillo, Luis Cottet, Andrea Mahn
Myrosinase is a glycosylated enzyme present in the Brassicaceae family that catalyzes the hydrolysis of glucoraphanin to yield sulforaphane, recognized as a health-promoting compound found in cruciferous foods. Broccoli myrosinase has been poorly characterized. In this work, the enzyme was purified from broccoli florets and its kinetic behaviour was analyzed. The cDNA of broccoli myrosinase was isolated and sequenced to obtain the amino acids sequence of the enzyme. A three-dimensional structural model of a broccoli myrosinase subunit was built and used to perform molecular docking simulations with glucoraphanin and other glucosinolates...
July 15, 2018: Food Chemistry
Jian-Chao Zhao, Juan Cheng, Qi Zhang, Zi-Wei Gao, Meng-Yue Zhang, Yi-Xuan Zhang
A Gram-stain-negative, strictly aerobic, yellow-coloured, motile by gliding and elongated rod-shaped bacterial strain, designated SYP-B1015T , was isolated from the rhizosphere of Artemisia annua L. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain SYP-B1015T belonged to the genus Flavobacterium and had highest 16S rRNA gene sequence similarity to Flavobacterium compostarboris JCM 16527T (98.1 %) and Flavobacterium procerum JCM 30113T (97.2 %). The predominant respiratory quinone for the strain was MK-6, and the major cellular fatty acids were iso-C15 : 0, iso-C15 : 0 3-OH and iso-C17 : 0 3-OH...
March 16, 2018: International Journal of Systematic and Evolutionary Microbiology
Nimai Pathak, Partha Sarathi Ghosh, Suryansh Saxena, Dhanadeep Dutta, Ashok Kumar Yadav, Dibyendu Bhattacharyya, Shambhu Nath Jha, Ramakant Mahadeo Kadam
Activator-free zinc aluminate (ZA) nanophosphor was synthesized through a sol-gel combustion route, which can be used both as a blue-emitting phosphor material and a white-emitting phosphor material, depending on the annealing temperature during synthesis. The material also has the potential to be used in optical thermometry. These fascinating color-tunable emission characteristics can be linked with the various defect centers present inside the matrix and their changes upon thermal annealing. Various defect centers, such as anionic vacancy, cationic vacancy, antisite defect, etc...
March 16, 2018: Inorganic Chemistry
Zia Uddin, Yeong Hun Song, Mahboob Ullah, Zuopeng Li, Jeong Yoon Kim, Ki Hun Park
Diabetes mellitus is one of a major worldwide concerns, regulated by either defects in secretion or action of insulin, or both. Insulin signaling down-regulation has been related with over activity of protein tyrosine phosphatase 1B (PTP1B) enzyme, which has been a promising target for the treatment of diabetes mellitus. Herein, activity guided separation of methanol extract (95%) of Dodonaea viscosa aerial parts afforded nine ( 1 - 9 ) polyphenolic compounds, all of them were identified through spectroscopic data including 2D NMR and HREIMS...
2018: Frontiers in Chemistry
Jan Paulo T Zaragoza, Maxime A Siegler, David P Goldberg
High-valent metal-hydroxide species are invoked as critical intermediates in both catalytic, metal-mediated O2 activation (e.g., by Fe porphyrin in Cytochrome P450) and O2 production (e.g., by the Mn cluster in Photosystem II). However, well-characterized mononuclear MIV (OH) complexes remain a rarity. Herein we describe the synthesis of MnIV (OH)(ttppc) (3) (ttppc = tris(2,4,6-triphenylphenyl) corrole), which has been characterized by X-ray diffraction (XRD). The large steric encumbrance of the ttppc ligand allowed for isolation of 3...
March 15, 2018: Journal of the American Chemical Society
Isabel Cristina Vieira da Silva, Goran Kaluderovic, Pollyana Felix de Oliveira, Denise Oliveira Guimaraes, Carla Holandino Quaresma, Andrea Porzel, Michelle Frazao Muzitano, Ludger A Wessjohann, Ivana Correa Ramos Leal
The genus Passiflora is knew for food consumption mainly and it extracts present a variety of methabolites, including flavones, alkaloids and triterpenes usually correlated with their antioxidant and antitumoral activities. P. mucronata (Pm) is from Brazil South America and is characterized as "Maracujá de Restinga", being used in the folk medicine for treating insomnia and soothing. The present study evaluated in the first time, the antioxidant and cytotoxicity of the hydroalcoholic leaves extract and fractions from Pm...
March 14, 2018: Anti-cancer Agents in Medicinal Chemistry
Takashi Uchikura, Hiroaki Tanaka, Hidemi Sugiwaki, Morio Yoshimura, Naoko Sato-Masumoto, Takashi Tsujimoto, Nahoko Uchiyama, Takashi Hakamatsuka, Yoshiaki Amakura
A new phenolic compound, 2- O -β-laminaribiosyl-4-hydroxyacetophenone ( 1 ), was isolated from Cynanchi Wilfordii Radix (CWR, the root of Cynanchum wilfordii Hemsley), along with 10 known aromatic compounds, including cynandione A ( 2 ), bungeisides-C ( 7 ) and -D ( 8 ), p -hydroxyacetophenone ( 9 ), 2',5'-dihydroxyacetophenone ( 10 ), and 2',4'-dihydroxyacetophenone ( 11 ). The structure of the new compound ( 1 ) was elucidated using spectroscopic methods and chemical methods. The structure of cynandione A ( 2 ), including a linkage mode of the biphenyl parts that remained uncertain, was unambiguously confirmed using the 2D13 C-13 C incredible natural abundance double quantum transfer experiment (INADEQUATE) spectrum...
March 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yong-Zhe Zhu, Jing-Wen Liu, Xue Wang, In-Hong Jeong, Young-Joon Ahn, Chuan-Jie Zhang
The human β-site amyloid cleaving enzyme (BACE1) has been considered as an effective drug target for treatment of Alzheimer's disease (AD). In this study, Urechis unicinctus (U. unicinctus) , which is a Far East specialty food known as innkeeper worm, ethanol extract was studied by bioassay-directed fractionation and isolation to examine its potential β-site amyloid cleaving enzyme inhibitory and antimicrobial activity. The following compounds were characterized: hecogenin, cholest-4- en -3-one, cholesta-4,6- dien -3-ol, and hurgadacin...
March 14, 2018: Marine Drugs
Adejoke N Kolawole, Valentine T Akinladejo, Olusola O Elekofehinti, Afolabi C Akinmoladun, Ayodele O Kolawole
Aldehyde dehydrogenases (ALDHs) are a diverse family of enzymes that catalyze the NAD(P)+ -dependent detoxification of toxic aldehyde compounds. ALDHs are also involved in non-enzymatic ligand binding to endobiotics and xenobiotics. Here, the enzyme crucial non-canonical and non-catalytic interaction with kolaflavanone, a component of kolaviron, and a major bioflavonoid isolated from Garcinia kola (Bitter kola) was characterized by various spectroscopic and in silico approaches under stimulated physiological condition...
February 27, 2018: Bioorganic Chemistry
Zuo Peng Li, Hyeong-Hwan Lee, Zia Uddin, Yeong Hun Song, Ki Hun Park
Four new caged xanthones (1-4) and two known compounds (5, 6) were isolated from the roots of Cratoxylum cochinchinense, a polyphenol rich plant, collected in China. The structures of the isolated compounds (1-6) were characterized by obtaining their detailed spectroscopic data. In particular, compounds 1 and 6 were fully identified by X-ray crystallographic data. The isolated compounds (1-6) were evaluated against protein tyrosine phosphatase 1B (PTP1B), which plays an important role in diabetes, obesity, and cancer...
March 7, 2018: Bioorganic Chemistry
Yu Cao, Hualiang Pi, Pete Chandrangsu, Yongtao Li, Yuqi Wang, Han Zhou, Hanqin Xiong, John D Helmann, Yanfei Cai
Plant growth promoting rhizobacteria (PGPR) provide an effective and environmentally sustainable method to protect crops against pathogens. The spore-forming Bacilli are attractive PGPR due to their ease of storage and application. Here, we characterized two rhizosphere-associated Bacillus velezensis isolates (Y6 and F7) that possess strong antagonistic activity against Ralstonia solanacearum and Fusarium oxysporum under both laboratory and greenhouse conditions. We identified three lipopeptide (LP) compounds (surfactin, iturin and fengycin) as responsible for the antimicrobial activity of these two strains...
March 12, 2018: Scientific Reports
Peter Werner Roesky, Christoph Schoo, Sebastian Bestgen, Alexander Egeberg, Svetlana Klementieva, Claus Feldmann, Sergey N Konchenko
Zintl-ions in molecular compounds are of fundamental interest for basic research and application. However, in contrast to the lighter group 15 elements, elemental antimony has never been applied as reagent for the preparation of molecular polystibides. Herein, we report for the first time two reactive antimony sources, which allow the direct access to molecular polystibide compounds. These are Sb amalgam (Sb/Hg) and ultrasmall Sb0 nanoparticles (d = 6.6±0.8 nm), which were used independently as precursors for the synthe-sis of the largest f-element polystibide, [(Cp*2Sm)4Sb8]...
March 12, 2018: Angewandte Chemie
K Soumya, K Narasimha Murthy, G L Sreelatha, T Sharmila
AIM: This research aims to characterize the pigment produced by isolated fungi and to evaluate its anti-cancer activities. METHODS AND RESULTS: Pigment producing fungi was isolated and identified as Fusarium chlamydosporum. The pigment was extracted with chloroform, purified by PTLC and characterized by FT-IR, ESIMS, LCMS and NMR (1 HNMR,13 C NMR) spectral analysis, which revealed the pigment to be "long chain hydrocarbons with poly unsaturated groups" (m/z 702)...
March 12, 2018: Journal of Applied Microbiology
Aaron Korkegian, Theresa O'Malley, Yi Xia, Yasheen Zhou, David S Carter, Bjorn Sunde, Lindsay Flint, Dean Thompson, Thomas R Ioerger, Jim Sacchettini, M R K Alley, Tanya Parish
We identified a series of novel 7-phenyl benzoxaborole compounds with activity against Mycobacterium tuberculosis. Compounds had a range of activity with inhibitory concentrations (IC90 ) as low as 5.1 μM and no cytotoxicity against eukaryotic cells (IC50  > 50 μM). Compounds were active against intracellular mycobacteria cultured in THP-1 macrophages. We isolated and characterized resistant mutants with mutations in NADH dehydrogenase (Ndh) or the regulatory protein Mce3R. Mutations suggest that Ndh may be the target of this series...
January 2018: Tuberculosis
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"