Masanori Terashima, Kazumasa Fujitani, Han-Kwang Yang, Junki Mizusawa, Toshimasa Tsujinaka, Kenichi Nakamura, Hiroshi Katayama, Hyuk-Joon Lee, Jun Ho Lee, Ji-Yeong An, Akinori Takagane, Young-Kyu Park, Seung Ho Choi, Kyo Young Song, Seiji Ito, Do Joong Park, Sung-Ho Jin, Narikazu Boku, Takaki Yoshikawa, Mitsuru Sasako
BACKGROUND: REGATTA trial failed to demonstrate the survival benefit of reduction gastrectomy in patients with advanced gastric cancer with a single non-curable factor. However, a significant interaction was found between the treatment effect and tumor location in the subset analysis. Additionally, the treatment effect appeared to be different between Japan and Korea. This supplementary analysis aimed to elucidate the effect of reduction surgery based on tumor location and country. METHODS: Multivariable Cox regression analyses in each subgroup were performed to estimate the hazard ratio (HRadj), including the following variables as explanatory variables: country, age, sex, incurable factor, cT, cN, primary tumor, performance status, histological type, and macroscopic type...
September 2023: Annals of Gastroenterological Surgery