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https://www.readbyqxmd.com/read/28955031/printing-of-small-molecular-medicines-from-the-vapor-phase
#1
Olga Shalev, Shreya Raghavan, J Maxwell Mazzara, Nancy Senabulya, Patrick D Sinko, Elyse Fleck, Christopher Rockwell, Nicholas Simopoulos, Christina M Jones, Anna Schwendeman, Geeta Mehta, Roy Clarke, Gregory E Amidon, Max Shtein
There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles...
September 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28887957/accelerated-healing-of-full-thickness-dermal-wounds-by-macroporous-waterborne-polyurethane-chitosan-hydrogel-scaffolds
#2
Kamakshi Bankoti, Arun Prabhu Rameshbabu, Sayanti Datta, Priti Prasanna Maity, Piyali Goswami, Pallab Datta, Sudip Kumar Ghosh, Analava Mitra, Santanu Dhara
Wound healing is a dynamic process wherein cells, and macromolecules work in consonance to facilitate tissue regeneration and restore tissue integrity. In the case of full-thickness (FT) wounds, healing requires additional support from native or synthetic matrices to aid tissue regeneration. In particular, a matrix with optimum hydrophilic-hydrophobic balance which will undergo adequate swelling as well as reduce bacterial adhesion has remained elusive. In the present study, polyurethane diol dispersion (PUD) and the anti-bacterial chitosan (Chn) were blended in different ratios which self-organized to form macroporous hydrogel scaffolds (MHS) at room temperature on drying...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28837756/scalable-manufacturing-of-solderable-and-stretchable-physiologic-sensing-systems
#3
Yun-Soung Kim, Jesse Lu, Benjamin Shih, Armen Gharibans, Zhanan Zou, Kristen Matsuno, Roman Aguilera, Yoonjae Han, Ann Meek, Jianliang Xiao, Michael T Tolley, Todd P Coleman
Methods for microfabrication of solderable and stretchable sensing systems (S4s) and a scaled production of adhesive-integrated active S4s for health monitoring are presented. S4s' excellent solderability is achieved by the sputter-deposited nickel-vanadium and gold pad metal layers and copper interconnection. The donor substrate, which is modified with "PI islands" to become selectively adhesive for the S4s, allows the heterogeneous devices to be integrated with large-area adhesives for packaging. The feasibility for S4-based health monitoring is demonstrated by developing an S4 integrated with a strain gauge and an onboard optical indication circuit...
August 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28697034/iatrogenic-endotracheal-tube-obstruction-by-tegaderm
#4
Lance S Patak
No abstract text is available yet for this article.
July 10, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28650050/bilayered-nanofibrous-3d-hierarchy-as-skin-rudiment-by-emulsion-electrospinning-for-burn-wound-management
#5
Pallabi Pal, Prabhash Dadhich, Pavan Kumar Srivas, Bodhisatwa Das, Dhrubajyoti Maulik, Santanu Dhara
Mimicking skin extracellular matrix hierarchy, the present work aims to develop a bilayer skin graft comprising a porous cotton-wool-like 3D layer with membranous structure of PCL-chitosan nanofibers. Emulsion electrospinning with differential stirring periods of PCL-chitosan emulsion results in development of a bilayer 3D structure with varied morphology. The electrospun membrane has fiber diameter ∼274 nm and pore size ∼1.16 μm while fluffy 3D layer has fiber diameter ∼1.62 μm and pore size ∼62 μm...
August 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28599034/a-prospective-randomized-controlled-two-arm-clinical-study-evaluating-the-efficacy-of-a-bioelectric-dressing-system-for-blister-management-in-us-army-ranger-recruits
#6
RANDOMIZED CONTROLLED TRIAL
Greggory J Housler, Sue Cross, Vanessa Marcel, Daniel O Kennedy, Michael Husband, Andrew Register, Thomas Roberts, Seth Grubbs, Douglas Dudewicz, Nathan Setka, Curt Bay, Martin E Wendelken, Mina J Izadjoo
This study focused on a clinically relevant healthcare problem in the military: acute soft tissue wounds, or blisters. The trial was a prospective, controlled, randomized two-arm study evaluating the efficacy of a bioelectric dressing, Procellera®, applied topically two to three times per week for 2 weeks to blisters developed in Ranger trainees during training at Fort Benning, Georgia. A total of 80 US Army Ranger recruits with blister wounds below the knee were randomly assigned to one of two treatment groups (n = 40/group)...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28598757/exudates-absorption-and-proteases-trapping-in-venous-leg-ulcers
#7
P Humbert, C Courderot-Masuyer, S Robin, D Oster, R Pegahi
OBJECTIVE: In venous leg ulcer (VLU), the impaired healing has been shown to be associated with excessive levels of protease activities such as matrix metalloproteinases (MMPs) and elastases found in exudates. The present study focused on exudates absorption and proteases trapping capacity of a new generation of polyacrylate superabsorbent, Tegaderm superabsorber (TS), compared with a traditional dressing such as Zetuvit. METHOD: We studied the proteases implicated in VLU (MMP-1, MMP-2, MMP-9 and PMN elastase)...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28529754/chitosan-poly-caprolactone-nanofibers-for-skin-repair
#8
Sheeny Lan Levengood, Ariane E Erickson, Fei-Chien Chang, Miqin Zhang
Dermal wounds, both acute and chronic, represent a significant clinical challenge and therefore the development of novel biomaterial-based skin substitutes to promote skin repair is essential. Nanofibers have garnered attention as materials to promote skin regeneration due to the similarities in morphology and dimensionality between nanofibers and native extracellular matrix proteins, which are critical in guiding cutaneous wound healing. Electrospun chitosan-poly(caprolactone) (CPCL) nanofiber scaffolds, which combine the important intrinsic biological properties of chitosan and the mechanical integrity and stability of PCL, were evaluated as skin tissue engineering scaffolds using a mouse cutaneous excisional skin defect model...
March 7, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28458029/heparin-mimetic-peptide-nanofiber-gel-promotes-regeneration-of-full-thickness-burn-injury
#9
Fatih Yergoz, Nurcan Hastar, Cagla Eren Cimenci, Alper Devrim Ozkan, Turgay Tekinay, Mustafa O Guler, Ayse B Tekinay
Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, functional and biodegradable peptide nanofiber gels for the improved healing of burn wounds to alleviate the progressive loss of tissue function at the post-burn wound site. These bioactive nanofiber gels form scaffolds that recapitulate the structure and function of the native extracellular matrix through signaling peptide epitopes, which can trigger angiogenesis through their affinity to basic growth factors...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28365169/clinic-meatotomy-under-topical-anesthesia
#10
C M Fronczak, C A Villanueva
OBJECTIVES: Almost 20 years after Cartwright et al. (1996) demonstrated the feasibility and effectiveness of clinic meatotomy (CM) under topical lidocaine and prilocaine (EMLA) anesthesia, 50% of meatotomies are still performed under general anesthesia (GA) (Godley et al., 2015). The cost of a meatotomy under GA is approximately 10 times the cost of CM in the present practice. This study presented the outcomes for CM under topical anesthesia, in consecutive patients who presented with meatal stenosis secondary to circumcision...
October 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28107663/antibacterial-anti-oxidant-electroactive-injectable-hydrogel-as-self-healing-wound-dressing-with-hemostasis-and-adhesiveness-for-cutaneous-wound-healing
#11
Xin Zhao, Hao Wu, Baolin Guo, Ruonan Dong, Yusheng Qiu, Peter X Ma
Injectable self-healing hydrogel dressing with multifunctional properties including anti-infection, anti-oxidative and conductivity promoting wound healing process will be highly desired in wound healing application and its design is still a challenge. We developed a series of injectable conductive self-healed hydrogels based on quaternized chitosan-g-polyaniline (QCSP) and benzaldehyde group functionalized poly(ethylene glycol)-co-poly(glycerol sebacate) (PEGS-FA) as antibacterial, anti-oxidant and electroactive dressing for cutaneous wound healing...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/27582899/economic-impact-of-tegaderm-chlorhexidine-gluconate-chg-dressing-in-critically-ill-patients
#12
Praveen Thokala, Martin Arrowsmith, Edith Poku, Marissa Martyn-St James, Jeff Anderson, Steve Foster, Tom Elliott, Tony Whitehouse
PURPOSE: To estimate the economic impact of a Tegaderm(TM) chlorhexidine gluconate (CHG) gel dressing compared with a standard intravenous (i.v.) dressing (defined as non-antimicrobial transparent film dressing), used for insertion site care of short-term central venous and arterial catheters (intravascular catheters) in adult critical care patients using a cost-consequence model populated with data from published sources. MATERIAL AND METHODS: A decision analytical cost-consequence model was developed which assigned each patient with an indwelling intravascular catheter and a standard dressing, a baseline risk of associated dermatitis, local infection at the catheter insertion site and catheter-related bloodstream infections (CRBSI), estimated from published secondary sources...
September 2016: Journal of Infection Prevention
https://www.readbyqxmd.com/read/27516139/tegaderm%C3%A2-chg-dressing-significantly-improves-catheter-related-infection-rate-in-hemodialysis-patients
#13
Marco Righetti, Nicola Palmieri, Oscar Bracchi, Mario Prencipe, Elena Bruschetta, Francesca Colombo, Irene Brenna, Francesca Stefani, Karen Amar, Alfio Scalia, Ferruccio Conte
INTRODUCTION: Catheter-related infections are an important clinical problem in maintenance hemodialysis patients. Catheter-related bloodstream infections have a negative effect on survival, hospitalization and cost of care. Tegaderm™ chlorhexidine gluconate (CHG) dressing may be useful to reduce catheter-related infection rates. METHODS: We performed a study to assess the efficacy of Tegaderm™ CHG dressing for reducing catheter-related infections. We designed a prospective randomized cross-over study with a scheme of two treatments, Tegaderm™ CHG dressing versus standard dressing, and two periods of six months...
September 21, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27467651/clinical-evaluation-of-a-securement-device-used-on-midline-catheters
#14
Roy Ventura, Chris O'Loughlin, Boris Vavrik
Since the introduction of sutureless securement products for vascular access devices (VADs), there has been a great deal of discussion of their advantages and disadvantages in comparison with sutures. This includes questions related to VAD securement, patients' comfort, infection control, user-friendliness and potential complications of using the device. The literature review of the available evidence indicates the superiority of the novel sutureless devices in the aforementioned aspects. The authors collected data to further contribute in the analysis of the attributes of these products, namely Statlock™ and Grip-Lok™ (current devices)...
July 28, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27155806/pediatric-penile-reconstruction-using-autologous-split-thickness-skin-graft
#15
E C Diaz, J F Corcoran, E K Johnson
This video provides a case report of penis entrapment secondary to excessive skin removal during circumcision. It highlights the technical aspects of pediatric penile reconstruction using autologous split-thickness skin graft (STSG). Key points include: 1. Infection prevention is paramount and antibiotic prophylaxis is routine. 2. The usual harvest site for the STSG is the lateral thigh because of its source of glabrous skin and convenient proximity to the penis. The lateral thigh is also outside of the diapered area, which helps lessen postoperative pain and infectious risks...
June 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27144903/withdrawn-gauze-and-tape-and-transparent-polyurethane-dressings-for-central-venous-catheters
#16
REVIEW
Joan Webster, Donna Gillies, Elizabeth O'Riordan, Karen L Sherriff, Claire M Rickard
No abstract text is available yet for this article.
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26986991/a-novel-approach-to-keloid-reconstruction-with-bilaminar-dermal-substitute-and-epidermal-skin-grafting
#17
Khang T Nguyen, Lauren Shikowitz, Armen K Kasabian, Nicholas Bastidas
BACKGROUND: Keloids represent a challenging problem. Surgical excision remains the definitive treatment for immediate lesion debulking, but recurrence rates are reported to be 45 to 100 percent. The authors present a staged reconstructive approach using a dermal regeneration substrate and epidermal grafting to minimize recurrence and donor-site morbidity. METHODS: Keloids were completely excised down to normal subcutaneous tissue or perichondrium. A bilaminar dermal regeneration matrix was approximated to the entire wound, with the silicone lamina oriented superficially...
July 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26762497/wound-dressing-following-primary-total-hip-arthroplasty-a-prospective-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
M Siddiqui, A Bidaye, E Baird, R Abu-Rajab, A Stark, B Jones, R Ingram, I Anthony
OBJECTIVE: This study compared three methods of surgical wound dressing in patients undergoing primary total hip arthroplasty to determine their effect on wound leakage. METHOD: Total hip arthroplasties were randomised to 3 groups: 2-octyl cyanoacrylate (Dermabond-Ethicon Inc, G) with Opsite (Smith & Nephew; O) [G+O], 2-octyl cyanoacrylate with Tegaderm (3M; T) [G+T], and Opsite without 2-octyl cyanoacrylate [O]. Postoperative wound leakage was assessed and graded daily until discharge, the frequency of the dressing changes was also recorded...
January 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/26712088/intrapartum-epidural-fixation-methods-a-randomised-controlled-trial-of-three-different-epidural-catheter-securement-devices
#19
RANDOMIZED CONTROLLED TRIAL
P M Odor, S Bampoe, J Hayward, I Chis Ster, E Evans
This randomised controlled trial investigated the efficacy of Epi-Fix(™) , LockIt Plus(®) and Tegaderm(™) as fixation devices for intrapartum epidural catheters. One hundred and sixty-five women requesting intrapartum epidural analgesia were randomised to receive different fixation devices to secure their epidural catheter. The amount of epidural catheter migration (measured to the nearest 0.5 cm) was analysed for three devices: Epi-Fix (n = 55); LockIt Plus (n = 54); and Tegaderm dressing (n = 51). Median (IQR [range]) catheter migration for Epi-Fix was 1...
March 2016: Anaesthesia
https://www.readbyqxmd.com/read/26655820/effect-of-blocking-tactile-information-from-the-fingertips-on-adaptation-and-execution-of-grip-forces-to-friction-at-the-grasping-surface
#20
Seda Bilaloglu, Ying Lu, Daniel Geller, John Ross Rizzo, Viswanath Aluru, Esther P Gardner, Preeti Raghavan
Adaptation of fingertip forces to friction at the grasping surface is necessary to prevent use of inadequate or excessive grip forces. In the current study we investigated the effect of blocking tactile information from the fingertips noninvasively on the adaptation and efficiency of grip forces to surface friction during precision grasp. Ten neurologically intact subjects grasped and lifted an instrumented grip device with 18 different frictional surfaces under three conditions: with bare hands or with a thin layer of plastic (Tegaderm) or an additional layer of foam affixed to the fingertips...
March 2016: Journal of Neurophysiology
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