Abbas Fotovati, Samah Abu-Ali, Pei-Shan Wang, Loic P Deleyrolle, Cathy Lee, Joanna Triscott, James Y Chen, Sonia Franciosi, Yasuhiro Nakamura, Yasuo Sugita, Takeshi Uchiumi, Michihiko Kuwano, Blair R Leavitt, Sheila K Singh, Alexa Jury, Chris Jones, Hiroaki Wakimoto, Brent A Reynolds, Catherine J Pallen, Sandra E Dunn
The Y-box binding protein 1 (YB-1) is upregulated in many human malignancies including glioblastoma (GBM). It is also essential for normal brain development, suggesting that YB-1 is part of a neural stem cell (NSC) network. Here, we show that YB-1 was highly expressed in the subventricular zone (SVZ) of mouse fetal brain tissues but not in terminally differentiated primary astrocytes. Conversely, YB-1 knockout mice had reduced Sox-2, nestin, and musashi-1 expression in the SVZ. Although primary murine neurospheres were rich in YB-1, its expression was lost during glial differentiation...
August 15, 2011: Cancer Research